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Smoking in multiple sclerosis

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https://www.readbyqxmd.com/read/29908859/frailty-and-pre-frailty-in-middle-aged-and-older-adults-and-its-association-with-multimorbidity-and-mortality-a-prospective-analysis-of-493-737-uk-biobank-participants
#1
Peter Hanlon, Barbara I Nicholl, Bhautesh Dinesh Jani, Duncan Lee, Ross McQueenie, Frances S Mair
BACKGROUND: Frailty is associated with older age and multimorbidity (two or more long-term conditions); however, little is known about its prevalence or effects on mortality in younger populations. This paper aims to examine the association between frailty, multimorbidity, specific long-term conditions, and mortality in a middle-aged and older aged population. METHODS: Data were sourced from the UK Biobank. Frailty phenotype was based on five criteria (weight loss, exhaustion, grip strength, low physical activity, slow walking pace)...
June 13, 2018: Lancet. Public Health
https://www.readbyqxmd.com/read/29889061/early-sign-of-microangiopathy-in-systemic-sclerosis-the-significance-of-cold-stress-test-in-dynamic-laser-doppler-flowmetry
#2
Sebastian Yu, Stephen Chu-Sung Hu, Hsin-Su Yu, Yi-Ying Chin, Yang-Chun Cheng, Chih-Hung Lee
BACKGROUND: Skin physiology measurement is receiving more attention for detecting vasculopathy in systemic sclerosis (SSc). Laser Doppler flowmetry (LDF) is a widely used physiological measurement to assess cutaneous microcirculation. However, findings of LDF may be normal during early stage of microangiopathy in SSc. OBJECTIVE: We hypothesized that cold stress test combined with LDF could detect early-stage microangiopathy in patients with SSc. METHODS: A 67-year-old male came with multiple ulcerations on his fingers for one year...
June 5, 2018: Clinical Hemorheology and Microcirculation
https://www.readbyqxmd.com/read/29867705/association-of-pre-disease-body-mass-index-with-multiple-sclerosis-prognosis
#3
Ali Manouchehrinia, Anna Karin Hedström, Lars Alfredsson, Tomas Olsson, Jan Hillert, Ryan Ramanujam
Both high body mass index (BMI) and smoking tobacco are known risk factors for developing multiple sclerosis (MS). However, it is unclear whether BMI, like smoking, is a risk factor for the secondary progressive (SP) course. We, therefore, sought to determine if high/low BMI at age 20 is associated to risk of SP development, in the context of smoking status. Using data from MS patients with BMI and smoking information available, we examined relapsing onset patients with MS onset after 20 years of age. Cox regressions were conducted on smokers and non-smokers, with BMI as the main exposure...
2018: Frontiers in Neurology
https://www.readbyqxmd.com/read/29791509/health-outcomes-and-adherence-to-a-healthy-lifestyle-after-a-multimodal-intervention-in-people-with-multiple-sclerosis-three-year-follow-up
#4
Claudia H Marck, Alysha M De Livera, Chelsea R Brown, Sandra L Neate, Keryn L Taylor, Tracey J Weiland, Emily J Hadgkiss, George A Jelinek
BACKGROUND: Modifiable risk factors such as smoking and sedentary lifestyle adversely affect multiple sclerosis (MS) progression. Few multimodal behavioural interventions have been conducted for people with MS, and follow-up beyond 1 year is rare for lifestyle interventions. This study assessed adoption and adherence to healthy lifestyle behaviours and health outcomes 3 years after a lifestyle modification intervention, using generalized estimating equation models to account for within-participant correlation over time...
2018: PloS One
https://www.readbyqxmd.com/read/29735578/lifestyle-and-environmental-factors-in-multiple-sclerosis
#5
Lars Alfredsson, Tomas Olsson
Lifestyle and environmental factors potently influence the risk of multiple sclerosis (MS), because genetic predisposition only explains a fraction of the risk increase. There is strong evidence for associations of Epstein-Barr virus (EBV) infection, smoking, sun exposure/vitamin D, and adolescent obesity to risk of MS. There is also circumstantial evidence on organic solvents and shift work, all associate with greater risk, although certain factors like nicotine, alcohol, and a high coffee consumption associate with a reduced risk...
May 7, 2018: Cold Spring Harbor Perspectives in Medicine
https://www.readbyqxmd.com/read/29694270/higher-incidence-rates-of-comorbidities-in-patients-with-psoriatic-arthritis-compared-with-the-general-population-using-u-s-administrative-claims-data
#6
Jeffrey Kaine, Xue Song, Gilwan Kim, Peter Hur, Jacqueline B Palmer
BACKGROUND: Psoriatic arthritis (PsA) is associated with multiple comorbid conditions, including cardiovascular (CV) comorbidities that impose a considerable burden on patients. Effective management of PsA requires an understanding of comorbidity profiles. OBJECTIVE: To compare the frequency and incidence rates of comorbidities and hospitalizations among newly diagnosed PsA patients and a matched general population without PsA, using large national claims databases in the United States...
April 25, 2018: Journal of Managed Care & Specialty Pharmacy
https://www.readbyqxmd.com/read/29677591/lifestyle-factors-and-multiple-sclerosis-a-population-based-incident-case-control-study
#7
Ibrahim Abdollahpour, Saharnaz Nedjat, Mohammad Ali Mansournia, Mohammad Ali Sahraian, Ingrid van der Mei
OBJECTIVE: Although low sun exposure, low vitamin D, and smoking are established risk factor of multiple sclerosis (MS), there is less evidence on the role of the other lifestyle factors. We examined the association of sun exposure, physical activity, drug abuse, and alcohol intake with MS. MATERIALS AND METHODS: This was population-based incident case-control study in Iran with 547 incident cases and 1057 general population controls (7/8/2013-17/2/2015). Logistic regression was used to analyse the data...
May 2018: Multiple Sclerosis and related Disorders
https://www.readbyqxmd.com/read/29598831/smoking-under-hypoxic-conditions-a-potent-environmental-risk-factor-for-inflammatory-and-autoimmune-diseases
#8
REVIEW
Md Saddam Hussain, Vishwas Tripathi
Autoimmune disease management presents a significant challenge to medical science. Environmental factors potentially increase the risk of developing inflammatory and autoimmune diseases, such as multiple sclerosis, rheumatoid arthritis, and lupus. Among various environmental stresses, cigarette smoke and hypoxia have both been reported to lead to an enhanced risk of inflammatory and autoimmune diseases.In this review, we shed light on all reported mechanisms whereby cigarette smoke and a hypoxic environment can induce inflammatory and autoimmune diseases and discuss how hypoxic conditions influence the cigarette smoke-induced threat of inflammatory and autoimmune disease development...
March 30, 2018: Military Medical Research
https://www.readbyqxmd.com/read/29576504/multiple-sclerosis
#9
REVIEW
Alan J Thompson, Sergio E Baranzini, Jeroen Geurts, Bernhard Hemmer, Olga Ciccarelli
Multiple sclerosis continues to be a challenging and disabling condition but there is now greater understanding of the underlying genetic and environmental factors that drive the condition, including low vitamin D levels, cigarette smoking, and obesity. Early and accurate diagnosis is crucial and is supported by diagnostic criteria, incorporating imaging and spinal fluid abnormalities for those presenting with a clinically isolated syndrome. Importantly, there is an extensive therapeutic armamentarium, both oral and by infusion, for those with the relapsing remitting form of the disease...
April 21, 2018: Lancet
https://www.readbyqxmd.com/read/29542102/smoking-and-worsening-disability-in-multiple-sclerosis-a-meta-analysis
#10
P Heydarpour, A Manouchehrinia, O Beiki, S E Mousavi, A Abdolalizadeh, M Moradi -Lakeh, M A Sahraian
OBJECTIVES: Multiple sclerosis (MS) is a chronic demyelinating disorder affecting young adults. Environmental factors and lifestyle behaviors are pivotal in MS pathophysiology. Smoking has been considered as an important risk factor in MS. Various recent studies have been conducted to measure the role of smoking on worsening disability in patients with MS, thus we intended to systematically assess effect of smoking on evolution of disability in this study. MATERIALS & METHODS: We queried MEDLINE, EMBASE and Cochrane Library with following keywords "Multiple Sclerosis, Smoking, Tobacco Use, Disability" on December 1st 2016...
March 15, 2018: Acta Neurologica Scandinavica
https://www.readbyqxmd.com/read/29532745/association-of-smoking-but-not-hla-drb1-15-01-apoe-or-body-mass-index-with-brain-atrophy-in-early-multiple-sclerosis
#11
Christiane Graetz, Adriane Gröger, Felix Luessi, Anke Salmen, Daniela Zöller, Janine Schultz, Nelly Siller, Vinzenz Fleischer, Barbara Bellenberg, Achim Berthele, Viola Biberacher, Joachim Havla, Michael Hecker, Reinhard Hohlfeld, Carmen Infante-Duarte, Jan S Kirschke, Tania Kümpfel, Ralf Linker, Friedemann Paul, Steffen Pfeuffer, Philipp Sämann, Gerrit Toenges, Frank Weber, Uwe K Zettl, Antje Jahn-Eimermacher, Gisela Antony, Sergiu Groppa, Heinz Wiendl, Bernhard Hemmer, Mark Mühlau, Carsten Lukas, Ralf Gold, Christina M Lill, Frauke Zipp
BACKGROUND: The course of multiple sclerosis (MS) shows substantial inter-individual variability. The underlying determinants of disease severity likely involve genetic and environmental factors. OBJECTIVE: The aim of this study was to assess the impact of APOE and HLA polymorphisms as well as smoking and body mass index (BMI) in the very early MS course. METHODS: Untreated patients ( n = 263) with a recent diagnosis of relapsing-remitting (RR) MS or clinically isolated syndrome underwent standardized magnetic resonance imaging (MRI)...
March 1, 2018: Multiple Sclerosis: Clinical and Laboratory Research
https://www.readbyqxmd.com/read/29515171/author-correction-smoking-induces-dna-methylation-changes-in-multiple-sclerosis-patients-with-exposure-response-relationship
#12
Francesco Marabita, Malin Almgren, Louise K Sjöholm, Lara Kular, Yun Liu, Tojo James, Nimrod B Kiss, Andrew P Feinberg, Tomas Olsson, Ingrid Kockum, Lars Alfredsson, Tomas J Ekström, Maja Jagodic
A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has not been fixed in the paper.
March 7, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29514944/sun-exposure-over-the-life-course-and-associations-with-multiple-sclerosis
#13
Helen Tremlett, Feng Zhu, Alberto Ascherio, Kassandra L Munger
OBJECTIVE: To examine sun exposure and multiple sclerosis (MS) over the life course (ages 5-15 and 16-20 years, every 10 years thereafter). METHODS: Cases with MS (n = 151) and age-matched controls (n = 235) from the Nurses' Health Study cohorts completed summer, winter, and lifetime sun exposure history questionnaires. Cumulative ambient ultraviolet (UV)-B (based on latitude, altitude, cloud cover) exposure before MS onset was expressed as tertiles. Seasonal sun exposure was defined as low vs high hours per week (summer [≤9 vs >10 h/wk]; winter [≤3 vs >4 h/wk])...
April 3, 2018: Neurology
https://www.readbyqxmd.com/read/29510324/a-survey-of-dietary-characteristics-in-a-large-population-of-people-with-multiple-sclerosis
#14
Kathryn C Fitzgerald, Tuula Tyry, Amber Salter, Stacey S Cofield, Gary Cutter, Robert J Fox, Ruth Ann Marrie
INTRODUCTION: Dietary approaches to management of MS has been proposed for several decades, yet very little is known concerning dietary composition or adherence to specialized diets in people with multiple sclerosis (MS). METHODS: We conducted a survey of participants in the North American Research Committee on MS (NARCOMS) registry assessing diet composition and the prevalence of 19 different diets. We characterized prevalence of different diets and compared diet composition with estimated intakes from the National Health and Nutrition Examination Survey (NHANES) survey respondents and across demographics and MS clinical characteristics...
February 27, 2018: Multiple Sclerosis and related Disorders
https://www.readbyqxmd.com/read/29507104/mtor-suppresses-cigarette-smoke-induced-epithelial-cell-death-and-airway-inflammation-in-chronic-obstructive-pulmonary-disease
#15
Yong Wang, Juan Liu, Jie-Sen Zhou, Hua-Qiong Huang, Zhou-Yang Li, Xu-Chen Xu, Tian-Wen Lai, Yue Hu, Hong-Bin Zhou, Hai-Pin Chen, Song-Min Ying, Wen Li, Hua-Hao Shen, Zhi-Hua Chen
Airway epithelial cell death and inflammation are pathological features of chronic obstructive pulmonary disease (COPD). Mechanistic target of rapamycin (MTOR) is involved in inflammation and multiple cellular processes, e.g., autophagy and apoptosis, but little is known about its function in COPD pathogenesis. In this article, we illustrate how MTOR regulates cigarette smoke (CS)-induced cell death, airway inflammation, and emphysema. Expression of MTOR was significantly decreased and its suppressive signaling protein, tuberous sclerosis 2 (TSC2), was increased in the airway epithelium of human COPD and in mouse lungs with chronic CS exposure...
April 15, 2018: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/29479915/the-first-hospital-based-registry-of-patients-with-multiple-sclerosis-in-croatia
#16
Vanja Bašić Kes, Marijana Lisak, Miljenka Jurašić, Iris Zavoreo, Ana Dimitrović, Ivana Kobasić, Lucija Zadro Matovina
The first hospital-based registry of patients with multiple sclerosis (MS) was established at the University Department of Neurology, Sestre milosrdnice University Hospital Centre, Zagreb, Croatia, in 2014. The aim of the registry was to continuously provide data on the number of hospital-managed MS patients, patterns of disease progression, predictors of disability progression, changes in lifespan and long-term outcomes. Relevant medical data included age and gender of MS patients, family history of MS, data on previous immunization, disease course, Expanded Disability Status Scale (EDSS) score, cerebral magnetic resonance imaging (MRI) lesion load quantification, and cerebrospinal fluid analysis...
September 2017: Acta Clinica Croatica
https://www.readbyqxmd.com/read/29464378/smoking-at-time-of-cis-increases-the-risk-of-clinically-definite-multiple-sclerosis
#17
Roos M van der Vuurst de Vries, Julia Y Mescheriakova, Tessel F Runia, Theodora A M Siepman, Beatrijs H A Wokke, Johnny P A Samijn, Rogier Q Hintzen
BACKGROUND: Cigarette smoking is a modifiable risk factor that influences the disease course of patients with multiple sclerosis (MS). However, in patients with a clinically isolated syndrome (CIS), there are conflicting results about the association between smoking and the risk of a subsequent MS diagnosis. The aim of this study was to determine the risk of clinically definite MS (CDMS) in smoking and non-smoking patients at time of a first demyelinating event. METHODS: Two hundred and fifty patients, aged 18-50 years, were included in our prospective CIS cohort...
May 2018: Journal of Neurology
https://www.readbyqxmd.com/read/29438164/the-autoimmune-ecology-an-update
#18
Juan-Manuel Anaya, Paula Restrepo-Jiménez, Carolina Ramírez-Santana
PURPOSE OF REVIEW: The autoimmune ecology refers to the interactions between individuals and their environment leading to a breakdown in immune tolerance and, therefore, to the development of one or more autoimmune diseases in such an individual. Herein, an update is offered on four specific factors associated with autoimmune diseases, namely, vitamin D, smoking, alcohol and coffee consumption from the perspective of exposome and metabolomics. RECENT FINDINGS: Smoking is associated with an increased risk for most of the autoimmune diseases...
February 12, 2018: Current Opinion in Rheumatology
https://www.readbyqxmd.com/read/29423619/smoking-is-not-associated-with-higher-prevalence-of-jc-virus-in-ms-patients
#19
Michael Auer, Gabriel Bsteh, Harald Hegen, Franziska Di Pauli, Sebastian Wurth, Thomas Berger, Florian Deisenhammer
John Cunningham virus (JCV) causes rare, but potentially life-threatening progressive multifocal leukoencephalopathy (PML) in natalizumab-treated multiple sclerosis (MS) patients. Beside JCV index, there is currently no other factor for further risk stratification. Because smoking was reported as potential risk factor for several viral and bacterial infections, we aimed to investigate whether smoking could increase the risk for JCV infection in MS patients. We screened our database of the MS Clinic of the Department of Neurology, Medical University of Innsbruck, Austria, for patients with known smoking status and test result for anti-JCV antibody index as determined by two-step ELISA at Unilabs, Copenhagen, Denmark...
May 2018: European Journal of Clinical Microbiology & Infectious Diseases
https://www.readbyqxmd.com/read/29396631/fractional-anisotropy-of-white-matter-disability-and-blood-iron-parameters-in-multiple-sclerosis
#20
Estelle Herbert, Penelope Engel-Hills, Coenraad Hattingh, Jean-Paul Fouche, Martin Kidd, Christine Lochner, Maritha J Kotze, Susan J van Rensburg
Multiple sclerosis (MS) is a disorder related to myelin damage, which can be investigated by neuroimaging techniques such as fractional anisotropy (FA), a measure of microstructural white matter properties. The objectives of this study were to investigate (1) the relationship between FA and disability using an extremes of outcome approach, and (2) whether blood iron parameters were associated with FA and/or disability. Patients diagnosed with MS (n = 107; 14 males and 93 females) had iron parameter tests and disability determinations using the Expanded Disability Status Scale (EDSS)...
April 2018: Metabolic Brain Disease
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