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Smoking in multiple sclerosis

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https://www.readbyqxmd.com/read/29438164/the-autoimmune-ecology-an-update
#1
Juan-Manuel Anaya, Paula Restrepo-Jiménez, Carolina Ramírez-Santana
PURPOSE OF REVIEW: The autoimmune ecology refers to the interactions between individuals and their environment leading to a breakdown in immune tolerance and, therefore, to the development of one or more autoimmune diseases in such an individual. Herein, an update is offered on four specific factors associated with autoimmune diseases, namely, vitamin D, smoking, alcohol and coffee consumption from the perspective of exposome and metabolomics. RECENT FINDINGS: Smoking is associated with an increased risk for most of the autoimmune diseases...
February 12, 2018: Current Opinion in Rheumatology
https://www.readbyqxmd.com/read/29423619/smoking-is-not-associated-with-higher-prevalence-of-jc-virus-in-ms-patients
#2
Michael Auer, Gabriel Bsteh, Harald Hegen, Franziska Di Pauli, Sebastian Wurth, Thomas Berger, Florian Deisenhammer
John Cunningham virus (JCV) causes rare, but potentially life-threatening progressive multifocal leukoencephalopathy (PML) in natalizumab-treated multiple sclerosis (MS) patients. Beside JCV index, there is currently no other factor for further risk stratification. Because smoking was reported as potential risk factor for several viral and bacterial infections, we aimed to investigate whether smoking could increase the risk for JCV infection in MS patients. We screened our database of the MS Clinic of the Department of Neurology, Medical University of Innsbruck, Austria, for patients with known smoking status and test result for anti-JCV antibody index as determined by two-step ELISA at Unilabs, Copenhagen, Denmark...
February 8, 2018: European Journal of Clinical Microbiology & Infectious Diseases
https://www.readbyqxmd.com/read/29396631/fractional-anisotropy-of-white-matter-disability-and-blood-iron-parameters-in-multiple-sclerosis
#3
Estelle Herbert, Penelope Engel-Hills, Coenraad Hattingh, Jean-Paul Fouche, Martin Kidd, Christine Lochner, Maritha J Kotze, Susan J van Rensburg
Multiple sclerosis (MS) is a disorder related to myelin damage, which can be investigated by neuroimaging techniques such as fractional anisotropy (FA), a measure of microstructural white matter properties. The objectives of this study were to investigate (1) the relationship between FA and disability using an extremes of outcome approach, and (2) whether blood iron parameters were associated with FA and/or disability. Patients diagnosed with MS (n = 107; 14 males and 93 females) had iron parameter tests and disability determinations using the Expanded Disability Status Scale (EDSS)...
February 2, 2018: Metabolic Brain Disease
https://www.readbyqxmd.com/read/29393768/the-contribution-of-secondhand-tobacco-smoke-exposure-to-pediatric-multiple-sclerosis-risk
#4
Amy M Lavery, Bradley N Collins, Amy T Waldman, Chantelle N Hart, Amit Bar-Or, Ruth Ann Marrie, Douglas Arnold, Julia O'Mahony, Brenda Banwell
BACKGROUND: Pediatric acquired demyelinating syndromes (ADSs) are monophasic (mono-ADS) in 70% of cases and represent the first attack of multiple sclerosis (MS) in 30%. Secondhand tobacco smoke (SHS) exposure has been implicated as a risk factor for adult-onset MS. Little is known about whether SHS presents an additive risk beyond genetic factors and other environmental exposures associated with pediatric MS. METHODS: This study examined SHS exposure in 216 children with mono-ADS and 81 children with MS...
January 1, 2018: Multiple Sclerosis: Clinical and Laboratory Research
https://www.readbyqxmd.com/read/29353734/parental-ethnicity-associated-with-risk-for-multiple-sclerosis-a-population-based-incident-case-control-study-in-iran
#5
Ibrahim Abdollahpour, Saharnaz Nedjat, Mohammad Ali Mansournia, Mohammad Ali Sahraian, Nasrin Asgari
BACKGROUND: The epidemiology of multiple sclerosis (MS) includes a consideration of geography and population ethnicity. To determine whether there is any association between ethnicity and risk of MS in a multiethnic, population-based case-control study. METHODS: We conducted a population-based case-control of 547 incident MS cases and 1057 healthy controls between August 2013 and February 2015, Tehran, a multi-ethnic city. The patients were identified and enrolled through the Iranian MS Society...
January 17, 2018: Multiple Sclerosis and related Disorders
https://www.readbyqxmd.com/read/29343473/smoking-affects-the-interferon-beta-treatment-response-in-multiple-sclerosis
#6
Eva R Petersen, Annette B Oturai, Nils Koch-Henriksen, Melinda Magyari, Per S Sørensen, Finn Sellebjerg, Helle B Søndergaard
OBJECTIVE: To investigate whether smoking in patients with relapsing-remitting multiple sclerosis (RRMS) treated with interferon beta (IFN-β) is associated with the relapse rate and whether there is an interaction between smoking and human leukocyte antigen (HLA)-DRB1*15:01, HLA-A*02:01, and the N-acetyltransferase-1 (NAT1) variant rs7388368A. METHODS: DNA from 834 IFN-β-treated patients with RRMS from the Danish Multiple Sclerosis Biobank was extracted for genotyping...
January 17, 2018: Neurology
https://www.readbyqxmd.com/read/29311129/regulatory-t-cells-from-discovery-to-autoimmunity
#7
Alexandra Kitz, Emily Singer, David Hafler
Multiple sclerosis (MS) is a genetically mediated autoimmune disease of the central nervous system. Allelic variants lead to lower thresholds of T-cell activation resulting in activation of autoreactive T cells. Environmental factors, including, among others, diet, vitamin D, and smoking, in combination with genetic predispositions, play a substantial role in disease development and activation of autoreactive T cells. FoxP3+ regulatory T cells (Tregs) have emerged as central in the control of autoreactive T cells...
January 8, 2018: Cold Spring Harbor Perspectives in Medicine
https://www.readbyqxmd.com/read/29217748/lower-arterial-cross-sectional-area-of-carotid-and-vertebral-arteries-and-higher-frequency-of-secondary-neck-vessels-are-associated-with-multiple-sclerosis
#8
P Belov, D Jakimovski, J Krawiecki, C Magnano, J Hagemeier, L Pelizzari, B Weinstock-Guttman, R Zivadinov
BACKGROUND AND PURPOSE: Arterial and neck vessel system characteristics of patients with multiple sclerosis have not been previously investigated. Therefore, the aim of this study was to examine the frequency of neck vessels and their cross-sectional areas (in square millimeters) between patients with MS and healthy controls. MATERIALS AND METHODS: In this study, 193 patients with MS and 193 age- and sex-matched healthy controls underwent 2D TOF venography at 3T...
December 7, 2017: AJNR. American Journal of Neuroradiology
https://www.readbyqxmd.com/read/29212827/diet-quality-is-associated-with-disability-and-symptom-severity-in-multiple-sclerosis
#9
Kathryn C Fitzgerald, Tuula Tyry, Amber Salter, Stacey S Cofield, Gary Cutter, Robert Fox, Ruth Ann Marrie
OBJECTIVE: To assess the association between diet quality and intake of specific foods with disability and symptom severity in people with multiple sclerosis (MS). METHODS: In 2015, participants in the North American Research Committee on MS (NARCOMS) Registry completed a dietary screener questionnaire that estimates intake of fruits, vegetables and legumes, whole grains, added sugars, and red/processed meats. We constructed an overall diet quality score for each individual based on these food groups; higher scores denoted a healthier diet...
January 2, 2018: Neurology
https://www.readbyqxmd.com/read/29176769/decreased-prevalence-of-cancer-in-patients-with-multiple-sclerosis-a-case-control-study
#10
Xavier Moisset, Maud Perié, Bruno Pereira, Emilie Dumont, Christine Lebrun-Frenay, François-Xavier Lesage, Frederic Dutheil, Frederic Taithe, Pierre Clavelou
BACKGROUND: Studies of cancer prevalence have produced conflicting results concerning the relative risk of overall and specific sub-types of cancer in patients with multiple sclerosis (MS). Contemporary controls and information on tobacco use and alcohol consumption are generally missing from previous studies. OBJECTIVES: To evaluate lifetime cancer prevalence in a large cohort of MS patients relative to appropriate controls. METHODS: We conducted a case-control study, using a postal survey of a cohort of MS patients...
2017: PloS One
https://www.readbyqxmd.com/read/29174817/-bladder-cancer-in-neurogenic-patients-a-retrospective-study-of-management-and-follow-up
#11
P Ali, C Lefevre, B Perrouin-Verbe, L Le Normand, J Rigaud, O Bouchot, A Levesque, M-A Perrouin-Verbe
INTRODUCTION: The prevalence of bladder cancer (BC) in neurological patients seems to be similar to that of the general population. However, they are more aggressive with a higher rate of muscle-invasive forms and squamous cells carcinomas. The aim of the current study was to report etiologies, management and outcomes of BC in neurological population. MATERIAL AND METHOD: Were enrolled all neurological patients with a BC diagnosed between 2004 and 2017. The following data were retrospectively reported: age, gender, duration of the disease, mode of discovery, histological type, treatment and outcomes...
November 22, 2017: Progrès en Urologie
https://www.readbyqxmd.com/read/29109506/smoking-induces-dna-methylation-changes-in-multiple-sclerosis-patients-with-exposure-response-relationship
#12
Francesco Marabita, Malin Almgren, Louise K Sjöholm, Lara Kular, Yun Liu, Tojo James, Nimrod B Kiss, Andrew P Feinberg, Tomas Olsson, Ingrid Kockum, Lars Alfredsson, Tomas J Ekström, Maja Jagodic
Cigarette smoking is an established environmental risk factor for Multiple Sclerosis (MS), a chronic inflammatory and neurodegenerative disease, although a mechanistic basis remains largely unknown. We aimed at investigating how smoking affects blood DNA methylation in MS patients, by assaying genome-wide DNA methylation and comparing smokers, former smokers and never smokers in two Swedish cohorts, differing for known MS risk factors. Smoking affects DNA methylation genome-wide significantly, an exposure-response relationship exists and the time since smoking cessation affects methylation levels...
November 6, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29068493/managing-epstein-barr-virus-and-other-risk-factors-in-ms-future-perspectives
#13
REVIEW
P Sundström
Here, we discuss the rationale and feasibility of treatment directed against the modifiable risk factors in multiple sclerosis. The established environmental risk factors vitamin D insufficiency, cigarette smoke exposure, adolescence overweight, and Epstein-Barr virus infection are reviewed. Already available measures to target these risk factors are discussed.
November 2017: Acta Neurologica Scandinavica
https://www.readbyqxmd.com/read/29055473/the-effect-of-alcohol-and-red-wine-consumption-on-clinical-and-mri-outcomes-in-multiple-sclerosis
#14
Camilo Diaz-Cruz, Alicia S Chua, Muhammad Taimur Malik, Tamara Kaplan, Bonnie I Glanz, Svetlana Egorova, Charles R G Guttmann, Rohit Bakshi, Howard L Weiner, Brian C Healy, Tanuja Chitnis
BACKGROUND: Alcohol and in particular red wine have both immunomodulatory and neuroprotective properties, and may exert an effect on the disease course of multiple sclerosis (MS). OBJECTIVE: To assess the association between alcohol and red wine consumption and MS course. METHODS: MS patients enrolled in the Comprehensive Longitudinal Investigation of Multiple Sclerosis at the Brigham and Women's Hospital (CLIMB) who completed a self-administered questionnaire about their past year drinking habits at a single time point were included in the study...
October 2017: Multiple Sclerosis and related Disorders
https://www.readbyqxmd.com/read/29055468/evaluation-of-lithium-serum-level-in-multiple-sclerosis-patients-a-neuroprotective-element
#15
Atieh Karimi, Kobra Bahrampour, Mohammad Amin Momeni Moghaddam, Gholamreza Asadikaram, Ghasem Ebrahimi, Masoud Torkzadeh-Mahani, Mojdeh Esmaeili Tarzi, Mohammad Hadi Nematollahi
INTRODUCTION: It has been claimed that continuous and high production of nitric oxide (NO) and its metabolites may be involved in the pathogenesis of several neurological disorders such as multiple sclerosis. A number of studies have demonstrated that lithium regulates NO levels in disorders of the central nervous system. The aim of this study was to investigate whether NO as a marker of disease activity is correlated with lithium deficiency in relapsing remitting multiple sclerosis (RR-MS)...
October 2017: Multiple Sclerosis and related Disorders
https://www.readbyqxmd.com/read/29055459/smoking-and-multiple-sclerosis-a-systematic-review-and-meta-analysis-using-the-bradford-hill-criteria-for-causation
#16
REVIEW
Michelle L Degelman, Katya M Herman
BACKGROUND: Despite being one of the most common neurological disorders globally, the cause(s) of multiple sclerosis (MS) remain unknown. Cigarette smoking has been studied with regards to both the development and progression of MS. The Bradford Hill criteria for causation can contribute to a more comprehensive evaluation of a potentially causal risk factor-disease outcome relationship. The objective of this systematic review and meta-analysis was to assess the relationship between smoking and both MS risk and MS progression, subsequently applying Hill's criteria to further evaluate the likelihood of causal associations...
October 2017: Multiple Sclerosis and related Disorders
https://www.readbyqxmd.com/read/29027843/the-impact-of-vascular-risk-factors-on-brain-volume-and-lesion-load-in-patients-with-early-multiple-sclerosis
#17
Alexander Pichler, Michael Khalil, Christian Langkammer, Daniela Pinter, Stefan Ropele, Siegrid Fuchs, Gerhard Bachmaier, Christian Enzinger, Franz Fazekas
BACKGROUND: Vascular risk factors (VRF) in multiple sclerosis (MS) patients have been associated with lower brain volumes. It is currently unknown if this association already exists in early MS and how it develops over time. METHODS: We identified 82 patients with clinically isolated syndrome (CIS) ( n = 61) or with early relapsing-remitting MS ( n = 21) and assessed their VRF including arterial hypertension, hyperlipidaemia, diabetes mellitus and smoking. We analysed T2-lesion load, normalized brain volume (NBV), cortical grey (cGMV) and white matter volumes (WMV), thalamic and basal ganglia volumes at baseline and follow-up magnetic resonance imaging (MRI) and assessed the percentage of brain volume change (PBVC) using SIENA...
October 1, 2017: Multiple Sclerosis: Clinical and Laboratory Research
https://www.readbyqxmd.com/read/28938101/exposure-to-particulate-matter-air-pollution-and-risk-of-multiple-sclerosis-in-two-large-cohorts-of-us-nurses
#18
N Palacios, K L Munger, K C Fitzgerald, J E Hart, T Chitnis, A Ascherio, F Laden
BACKGROUND: Air pollution is thought to raise the risk of neurological disease by promoting neuroinflammation, oxidative stress, glial activation and cerebrovascular damage. Multiple Sclerosis is a common auto-immune disorder, primarily affecting young women. We conducted, to a large prospective study of particulate matter (PM) exposure and multiple sclerosis (MS) risk in two prospective cohorts of women: the Nurses Health Study (NHS) and the Nurses Health Study II (NHS II). METHODS: Cumulative average exposure to different size fractions of PM up to the onset of MS was estimated using spatio-temporal models...
December 2017: Environment International
https://www.readbyqxmd.com/read/28933265/the-role-of-vitamin-d-in-multiple-sclerosis-biology-biochemistry-epidemiology-and-potential-roles-in-treatment
#19
Steve Simpson, Ingrid van der Mei, Bruce Taylor
Multiple sclerosis (MS) is a progressive, demyelinating condition of the central nervous system, manifesting in loss or alterations in function of sensory, motor and cognitive function. Of the various environmental and behavioural risk factors identified as playing a role in MS onset and progression, perhaps none has been as consistent as vitamin D. OBJECTIVE: In this review, we will endeavour to present a general background on the role of vitamin D in human health and particularly in MS, as well as the substantial epidemiological evidence in support of vitamin D's role in MS...
September 21, 2017: Medicinal Chemistry
https://www.readbyqxmd.com/read/28928713/pain-in-people-with-multiple-sclerosis-associations-with-modifiable-lifestyle-factors-fatigue-depression-anxiety-and-mental-health-quality-of-life
#20
Claudia H Marck, Alysha M De Livera, Tracey J Weiland, Pia L Jelinek, Sandra L Neate, Chelsea R Brown, Keryn L Taylor, Fary Khan, George A Jelinek
BACKGROUND: People with multiple sclerosis (MS) often experience pain, which can interfere with mobility, employment, and quality of life (QOL). METHODS: This cross-sectional study explored associations between pain, demographic, disease, and modifiable lifestyle factors in an international sample of people with MS recruited online. RESULTS: Substantial pain, of moderate/severe intensity and interfering at least moderately with work/household or enjoyment of life in the past 4 weeks, was reported by 682/2,362 (28...
2017: Frontiers in Neurology
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