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Stephanie L. Martin

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https://www.readbyqxmd.com/read/28387666/increased-carbohydrate-intake-is-associated-with-poorer-performance-in-verbal-memory-and-attention-in-an-apoe-genotype-dependent-manner
#1
Samantha L Gardener, Stephanie R Rainey-Smith, Hamid R Sohrabi, Michael Weinborn, Giuseppe Verdile, W M A D Binosha Fernando, Yen Ying Lim, Karra Harrington, Samantha Burnham, Kevin Taddei, Colin L Masters, Stuart L Macaulay, Christopher C Rowe, David Ames, Paul Maruff, Ralph N Martins
Evidence suggests that a diet low in carbohydrates can impact on cognitive performance among those with Alzheimer's disease (AD). However, there is a lack of data assessing this relationship among cognitively normal (CN) older adults at increased future risk of developing AD due to carriage of the apolipoprotein E (APOE) ɛ4 allele. We assessed the cross-sectional association between carbohydrate intake, cognitive performance, and cerebral amyloid-β (Aβ) load in CN older adults, genotyped for APOEɛ4 allele carrier status...
April 3, 2017: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/28376661/succination-of-protein-disulfide-isomerase-links-mitochondrial-stress-to-endoplasmic-reticulum-stress-in-the-adipocyte-during-diabetes
#2
Allison M Manuel, Michael D Walla, Adam Faccenda, Stephanie L Martin, Ross M Tanis, Gerardo G Piroli, Julie Adam, Boris Kantor, Bulent Mutus, Danyelle M Townsend, Norma Frizzell
AIMS: Protein succination by fumarate increases in the adipose tissue of diabetic mice and in adipocytes matured in high glucose as a result of glucotoxicity driven mitochondrial stress. The endoplasmic reticulum (ER) oxidoreductase protein disulfide isomerase (PDI) is succinated in adipocytes matured in high glucose, and in this study we investigated if succination would alter PDI oxidoreductase activity, directly linking mitochondrial stress and ER stress. RESULTS: Protein succination and the ER stress marker CHOP are diminished following pharmaceutical targeting of mitochondrial stress with the chemical uncoupler niclosamide in adipocytes matured in high glucose concentrations...
April 4, 2017: Antioxidants & Redox Signaling
https://www.readbyqxmd.com/read/28375634/adsorption-of-oligo-dna-on-magnesium-aluminum-layered-double-hydroxide-nanoparticle-surfaces-mechanistic-implication-in-gene-delivery
#3
Kori A Andrea, Li Wang, Andrew J Carrier, Melanie Campbell, Margaret Buhariwalla, MacKenzi Mutch, Stephanie L MacQuarrie, Craig Bennett, Martin Mkandawire, Ken Oakes, Mingsheng Lu, Xu Zhang
Magnesium aluminum-layered double-hydroxide nanoparticles (LDH NPs) are promising drug-delivery vehicles for gene therapy, particularly for siRNA interference; however, the interactions between oligo-DNA and LDH surfaces have not been adequately elucidated. Through a mechanistic study, oligo-DNA initially appears to rapidly bind strongly to the LDH outer surfaces through interactions with their phosphate backbones via ligand exchange with OH(-) on Mg(2+) centers and electrostatic forces with Al(3+). These initial interactions might precede diffusion into interlayer spaces, and this knowledge can be used to design better gene therapy delivery systems...
April 10, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/28371896/an-analysis-of-patient-provider-secure-messaging-at-two-veterans-health-administration-medical-centers-message-content-and-resolution-through-secure-messaging
#4
Stephanie L Shimada, Beth Ann Petrakis, James A Rothendler, Maryan Zirkle, Shibei Zhao, Hua Feng, Gemmae M Fix, Mustafa Ozkaynak, Tracey Martin, Sharon A Johnson, Bengisu Tulu, Howard S Gordon, Steven R Simon, Susan S Woods
Objective: We sought to understand how patients and primary care teams use secure messaging (SM) to communicate with one another by analyzing secure message threads from 2 Department of Veterans Affairs facilities. Methods: We coded 1000 threads of SM communication sampled from 40 primary care teams. Results: Most threads (94.5%) were initiated by patients (90.4%) or caregivers (4.1%); only 5.5% were initiated by primary care team members proactively reaching out to patients...
March 24, 2017: Journal of the American Medical Informatics Association: JAMIA
https://www.readbyqxmd.com/read/28364346/the-growing-world-of-small-heat-shock-proteins-from-structure-to-functions
#5
REVIEW
Serena Carra, Simon Alberti, Patrick A Arrigo, Justin L Benesch, Ivor J Benjamin, Wilbert Boelens, Britta Bartelt-Kirbach, Bianca J J M Brundel, Johannes Buchner, Bernd Bukau, John A Carver, Heath Ecroyd, Cecilia Emanuelsson, Stephanie Finet, Nikola Golenhofen, Pierre Goloubinoff, Nikolai Gusev, Martin Haslbeck, Lawrence E Hightower, Harm H Kampinga, Rachel E Klevit, Krzysztof Liberek, Hassane S Mchaourab, Kathryn A McMenimen, Angelo Poletti, Roy Quinlan, Sergei V Strelkov, Melinda E Toth, Elizabeth Vierling, Robert M Tanguay
Small heat shock proteins (sHSPs) are present in all kingdoms of life and play fundamental roles in cell biology. sHSPs are key components of the cellular protein quality control system, acting as the first line of defense against conditions that affect protein homeostasis and proteome stability, from bacteria to plants to humans. sHSPs have the ability to bind to a large subset of substrates and to maintain them in a state competent for refolding or clearance with the assistance of the HSP70 machinery. sHSPs participate in a number of biological processes, from the cell cycle, to cell differentiation, from adaptation to stressful conditions, to apoptosis, and, even, to the transformation of a cell into a malignant state...
March 31, 2017: Cell Stress & Chaperones
https://www.readbyqxmd.com/read/28351093/angptl8-betatrophin-is-expressed-in-visceral-adipose-tissue-and-relates-to-human-hepatic-steatosis-in-two-independent-clinical-collectives
#6
Christian von Loeffelholz, Andreas F H Pfeiffer, Johan F Lock, Steffi Lieske, Stephanie Döcke, Veronica Murahovschi, Jennifer Kriebel, Tonia de Las Heras Gala, Harald Grallert, Natalia Rudovich, Martin Stockmann, Joachim Spranger, Gerhard Jahreis, Stefan R Bornstein, George Lau, Aimin Xu, Jeanette Schulz-Menger, Louisa Exner, Sven Haufe, Jens Jordan, Stefan Engeli, Andreas L Birkenfeld
Angiopoietin-like protein 8 (ANGPTL8)/betatrophin expression in visceral adipose tissue and associations with circulating fatty acid profile have not yet been investigated.Forty subjects were included in a cross-sectional study, 57 in a dietary weight reduction intervention. Circulating Angiopoietin-like protein 8/betatrophin was measured in all subjects. Liver and adipose tissue were sampled and plasma fatty acids and tissue Angiopoietin-like protein 8/betatrophin expression were evaluated in the cross-sectional study...
March 28, 2017: Hormone and Metabolic Research, Hormon- und Stoffwechselforschung, Hormones et Métabolisme
https://www.readbyqxmd.com/read/28346540/fragment-library-screening-identifies-hits-that-bind-to-the-non-catalytic-surface-of-pseudomonas-aeruginosa-dsba1
#7
Biswaranjan Mohanty, Kieran Rimmer, Róisín M McMahon, Stephen J Headey, Mansha Vazirani, Stephen R Shouldice, Mathieu Coinçon, Stephanie Tay, Craig J Morton, Jamie S Simpson, Jennifer L Martin, Martin J Scanlon
At a time when the antibiotic drug discovery pipeline has stalled, antibiotic resistance is accelerating with catastrophic implications for our ability to treat bacterial infections. Globally we face the prospect of a future when common infections can once again kill. Anti-virulence approaches that target the capacity of the bacterium to cause disease rather than the growth or survival of the bacterium itself offer a tantalizing prospect of novel antimicrobials. They may also reduce the propensity to induce resistance by removing the strong selection pressure imparted by bactericidal or bacteriostatic agents...
2017: PloS One
https://www.readbyqxmd.com/read/28337837/sulfated-hyaluronan-attenuates-inflammatory-signaling-pathways-in-macrophages-involving-induction-of-antioxidants
#8
Florent Jouy, Nadine Lohmann, Elke Wandel, Gloria Ruiz-Gómez, M Teresa Pisabarro, Annette G Beck-Sickinger, Matthias Schnabelrauch, Stephanie Moeller, Jan C Simon, Stefan Kalkhof, Martin von Bergen, Sandra Franz
It is well recognized that high molecular weight hyaluronan (H-HA) exerts potent anti-inflammatory effects while its fragmentation into low molecular weight HA (L-HA) is discussed to promote inflammation. Chemical modification of HA with sulfate groups has been shown to foster its anti-inflammatory activity which seems to be maintained in sulfated low molecular weight HA derivatives (sL-HA). However, the molecular mechanisms by which sL-HA produces its anti-inflammatory activity are not understood. In this study, we used global quantitative proteomics combined with targeted analysis of key proteins to characterize the effect of sL-HA on fully differentiated human inflammatory macrophages (iMФ)...
March 24, 2017: Proteomics
https://www.readbyqxmd.com/read/28333488/the-hierarchical-taxonomy-of-psychopathology-hitop-a-dimensional-alternative-to-traditional-nosologies
#9
Roman Kotov, Robert F Krueger, David Watson, Thomas M Achenbach, Robert R Althoff, R Michael Bagby, Timothy A Brown, William T Carpenter, Avshalom Caspi, Lee Anna Clark, Nicholas R Eaton, Miriam K Forbes, Kelsie T Forbush, David Goldberg, Deborah Hasin, Steven E Hyman, Masha Y Ivanova, Donald R Lynam, Kristian Markon, Joshua D Miller, Terrie E Moffitt, Leslie C Morey, Stephanie N Mullins-Sweatt, Johan Ormel, Christopher J Patrick, Darrel A Regier, Leslie Rescorla, Camilo J Ruggero, Douglas B Samuel, Martin Sellbom, Leonard J Simms, Andrew E Skodol, Tim Slade, Susan C South, Jennifer L Tackett, Irwin D Waldman, Monika A Waszczuk, Thomas A Widiger, Aidan G C Wright, Mark Zimmerman
The reliability and validity of traditional taxonomies are limited by arbitrary boundaries between psychopathology and normality, often unclear boundaries between disorders, frequent disorder co-occurrence, heterogeneity within disorders, and diagnostic instability. These taxonomies went beyond evidence available on the structure of psychopathology and were shaped by a variety of other considerations, which may explain the aforementioned shortcomings. The Hierarchical Taxonomy Of Psychopathology (HiTOP) model has emerged as a research effort to address these problems...
March 23, 2017: Journal of Abnormal Psychology
https://www.readbyqxmd.com/read/28328576/chronic-pain-patients-perspectives-of-medical-cannabis
#10
Brian J Piper, Monica L Beals, Alexander T Abess, Stephanie D Nichols, Maurice W Martin, Catherine M Cobb, Rebecca M DeKeuster
Medical cannabis (MC) is used for a variety of conditions including chronic pain. The goal of this report was to provide an in-depth qualitative exploration of patient perspectives on the strengths and limitations of MC. Members of MC dispensaries (N = 984) in New England including two-thirds with a history of chronic pain completed an online survey. In response to "How effective is medical cannabis in treating your symptoms or conditions?," with options of 0% "no relief" to 100% "complete relief," the average was 74...
March 21, 2017: Pain
https://www.readbyqxmd.com/read/28324046/characteristics-of-pediatric-vs-adult-pheochromocytomas-and-paragangliomas
#11
Christina Pamporaki, Barbora Hamplova, Mirko Peitzsch, Aleksander Prejbisz, Felix Beuschlein, Henri J L M Timmers, Martin Fassnacht, Barbara Klink, Maya Lodish, Constantine A Stratakis, Angela Huebner, Stephanie Fliedner, Mercedes Robledo, Richard O Sinnott, Andrzej Januszewicz, Karel Pacak, Graeme Eisenhofer
Context: Pheochromocytomas and paragangliomas (PPGLs) in children are often hereditary and may present with different characteristics compared with adults. Hereditary PPGLs can be separated into cluster 1 and cluster 2 tumors due to mutations impacting hypoxia and kinase receptor signaling pathways, respectively. Objective: To identify differences in presentation of PPGLs between children and adults. Design: A retrospective cross-sectional clinical study...
April 1, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28301395/increased-anatomic-severity-in-appendicitis-is-associated-with-outcomes-in-a-south-african-population
#12
Matthew C Hernandez, Victor Y Kong, Johnathon M Aho, John L Bruce, Stephanie F Polites, Grant L Laing, Martin D Zielinski, Damian L Clarke
BACKGROUND: Severity of emergency general surgery diseases (EGS) has not been standardized until recently. The American Association for the Surgery of Trauma (AAST) proposed an anatomic severity grading system for EGS diseases to facilitate communication and quality comparisons between providers and hospitals. Previous work has demonstrated validity of the system for appendicitis in the United States. In order to demonstrate generalizability, we aim to externally validate this grading system in South African patients with appendicitis...
March 15, 2017: Journal of Trauma and Acute Care Surgery
https://www.readbyqxmd.com/read/28264476/short-term-local-adaptation-of-historical-common-bean-phaseolus-vulgaris-l-varieties-and-implications-for-in-situ-management-of-bean-diversity
#13
Stephanie M Klaedtke, Leonardo Caproni, Julia Klauck, Paul de la Grandville, Martin Dutartre, Pierre M Stassart, Véronique Chable, Valeria Negri, Lorenzo Raggi
Recognizing both the stakes of traditional European common bean diversity and the role farmers' and gardeners' networks play in maintaining this diversity, the present study examines the role that local adaptation plays for the management of common bean diversity in situ. To the purpose, four historical bean varieties and one modern control were multiplied on two organic farms for three growing seasons. The fifteen resulting populations, the initial ones and two populations of each variety obtained after the three years of multiplication, were then grown in a common garden...
February 28, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28253385/association-of-steroid-5%C3%AE-reductase-type-3-congenital-disorder-of-glycosylation-with-early-onset-retinal-dystrophy
#14
Rachel L Taylor, Gavin Arno, James A Poulter, Kamron N Khan, Jiten Morarji, Sarah Hull, Nikolas Pontikos, Antonio Rueda Martin, Katherine R Smith, Manir Ali, Carmel Toomes, Martin McKibbin, Jill Clayton-Smith, Stephanie Grunewald, Michel Michaelides, Anthony T Moore, Alison J Hardcastle, Chris F Inglehearn, Andrew R Webster, Graeme C Black
Importance: Steroid 5α-reductase type 3 congenital disorder of glycosylation (SRD5A3-CDG) is a rare disorder of N-linked glycosylation. Its retinal phenotype is not well described but could be important for disease recognition because it appears to be a consistent primary presenting feature. Objective: To investigate a series of patients with the same mutation in the SRD5A3 gene and thereby characterize its retinal manifestations and other associated features. Design, Setting and Participants: Seven affected individuals from 4 unrelated families with early-onset retinal dystrophy as a primary manifestation underwent comprehensive ophthalmic assessment, including retinal imaging and electrodiagnostic testing...
March 2, 2017: JAMA Ophthalmology
https://www.readbyqxmd.com/read/28250195/adherence-specific-social-support-enhances-adherence-to-calcium-supplementation-regimens-among-pregnant-women
#15
Stephanie L Martin, Moshood O Omotayo, Gretel H Pelto, Gina M Chapleau, Rebecca J Stoltzfus, Katherine L Dickin
Background: WHO guidelines recommend integrating calcium supplementation into antenatal care (ANC) alongside iron and folic acid (IFA) to reduce maternal mortality. However, supplementation programs face multiple barriers, and strategies to improve adherence are needed. An adherence partner is someone whom pregnant women ask to support adherence at home.Objectives: This study 1) assessed adherence partner acceptability, feasibility, and associations with calcium and IFA supplement adherence and 2) examined relations between social support and adherence...
March 1, 2017: Journal of Nutrition
https://www.readbyqxmd.com/read/28248803/1-1-transfusion-strategies-are-right-for-the-wrong-reasons
#16
Stephanie A Savage, Ben L Zarzaur, Brian L Brewer, Garrett H Lim, Ali C Martin, Louis J Magnotti, Martin A Croce, Timothy H Pohlman
BACKGROUND: Early assessment of clot function identifies coagulopathies after injury. Abnormalities include a hypercoagulable state from excess thrombin generation, as well as an acquired coagulopathy. Efforts to address coagulopathy have resulted in earlier, aggressive use of plasma emphasizing 1:1 resuscitation. The purpose of this study was to describe coagulopathies in varying hemorrhagic profiles from a cohort of injured patients. METHODS: All injured patients who received at least one unit of packed red blood cells (PRBC) in the first 24 hours of admission from September 2013 to May 2015 were eligible for inclusion...
May 2017: Journal of Trauma and Acute Care Surgery
https://www.readbyqxmd.com/read/28241075/the-transcriptome-of-hiv-1-infected-intestinal-cd4-t-cells-exposed-to-enteric-bacteria
#17
Alyson C Yoder, Kejun Guo, Stephanie M Dillon, Tzu Phang, Eric J Lee, Michael S Harper, Karen Helm, John C Kappes, Christina Ochsenbauer, Martin D McCarter, Cara C Wilson, Mario L Santiago
Global transcriptome studies can help pinpoint key cellular pathways exploited by viruses to replicate and cause pathogenesis. Previous data showed that laboratory-adapted HIV-1 triggers significant gene expression changes in CD4+ T cell lines and mitogen-activated CD4+ T cells from peripheral blood. However, HIV-1 primarily targets mucosal compartments during acute infection in vivo. Moreover, early HIV-1 infection causes extensive depletion of CD4+ T cells in the gastrointestinal tract that herald persistent inflammation due to the translocation of enteric microbes to the systemic circulation...
February 2017: PLoS Pathogens
https://www.readbyqxmd.com/read/28238092/radial-shortening-osteotomy-reduces-radiocapitellar-contact-pressures-while-preserving-valgus-stability-of-the-elbow
#18
Michael Hackl, Kilian Wegmann, Stephanie L Kahmann, Nicolai Heinze, Manfred Staat, Wolfram F Neiss, Martin Scaal, Lars P Müller
PURPOSE: Shortening osteotomy of the proximal radius might represent a potential salvage procedure in symptomatic radiocapitellar osteoarthritis, which could decrease radiocapitellar load while preserving the native radial head. In an in-vitro biomechanical investigation, we sought to determine whether shortening osteotomy of the proximal radius (1) decreases the radiocapitellar joint pressure upon axial loading and (2) retains valgus stability of the elbow. In addition, the anatomic configuration of the lesser sigmoid notch was evaluated to assess possible contraindications...
February 25, 2017: Knee Surgery, Sports Traumatology, Arthroscopy: Official Journal of the ESSKA
https://www.readbyqxmd.com/read/28215403/performance-comparison-of-three-trypsin-columns-used-in-liquid-chromatography
#19
Tereza Šlechtová, Martin Gilar, Květa Kalíková, Stephanie M Moore, James W Jorgenson, Eva Tesařová
Trypsin is the most widely used enzyme in proteomic research due to its high specificity. Although the in-solution digestion is predominantly used, it has several drawbacks, such as long digestion times, autolysis, and intolerance to high temperatures or organic solvents. To overcome these shortcomings trypsin was covalently immobilized on solid support and tested for its proteolytic activity. Trypsin was immobilized on bridge-ethyl hybrid silica sorbent with 300Å pores, packed in 2.1×30mm column and compared with Perfinity and Poroszyme trypsin columns...
March 24, 2017: Journal of Chromatography. A
https://www.readbyqxmd.com/read/28207766/climate-change-across-seasons-experiment-ccase-a-new-method-for-simulating-future-climate-in-seasonally-snow-covered-ecosystems
#20
Pamela H Templer, Andrew B Reinmann, Rebecca Sanders-DeMott, Patrick O Sorensen, Stephanie M Juice, Francis Bowles, Laura E Sofen, Jamie L Harrison, Ian Halm, Lindsey Rustad, Mary E Martin, Nicholas Grant
Climate models project an increase in mean annual air temperatures and a reduction in the depth and duration of winter snowpack for many mid and high latitude and high elevation seasonally snow-covered ecosystems over the next century. The combined effects of these changes in climate will lead to warmer soils in the growing season and increased frequency of soil freeze-thaw cycles (FTCs) in winter due to the loss of a continuous, insulating snowpack. Previous experiments have warmed soils or removed snow via shoveling or with shelters to mimic projected declines in the winter snowpack...
2017: PloS One
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