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https://www.readbyqxmd.com/read/29227847/the-impact-of-histological-subtype-in-developing-both-ovarian-and-endometrial-cancer-a-longstanding-nationwide-incidence-study
#1
Catharina C van Niekerk, Jos A A M van Dijck, André L M Verbeek
OBJECTIVES: To estimate the incidence of ovarian cancer (OC) and endometrial cancer (EC) separately, as well as double cancers diagnosed in the same calendar year, and to relate the occurrences to histological subtype. STUDY DESIGN: All cases of epithelial OC and EC diagnosed in the Netherlands in 1989-2009 were related to population data. Histologically specific associations were made using the ratio of observed and expected incidence numbers, calculated with age-specific incidence rates...
December 7, 2017: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/29227175/effects-of-28-day-bifidobacterium-animalis-subsp-lactis-hn019-supplementation-on-colonic-transit-time-and-gastrointestinal-symptoms-in-adults-with-functional-constipation-a-double-blind-randomized-placebo-controlled-and-dose-ranging-trial
#2
Alvin Ibarra, Mathilde Latreille-Barbier, Yves Donazzolo, Xavier Pelletier, Arthur C Ouwehand
Bifidobacterium animalis subsp. lactis HN019 (HN019) ameliorates chronic idiopathic constipation. Our aim was to determine the efficacy and safety of 28-day supplementation with 1 × 109 or 1 × 1010 CFU of HN019/day for constipation. A total of 228 adults who were diagnosed with functional constipation according to the Rome III criteria were randomized in a double-blind and placebo-controlled trial. Colonic transit time (CTT), the primary outcome, and secondary outcomes that were measured using inventories-patient assessment of constipation symptoms (PAC-SYM) and quality of life (PAC-QoL), bowel function index (BFI), bowel movement frequency (BMF), stool consistency, degree of straining, bowel emptying, bloating, and pain severity-were assessed...
December 11, 2017: Gut Microbes
https://www.readbyqxmd.com/read/29225977/double-morphology-tertiary-syphilis-and-acquired-immunodeficiency-syndrome-a-rare-association
#3
R M Ngwanya, B Kakande, N P Khumalo
Background: Human immunodeficiency virus (HIV) and Treponema pallidum coinfection is relatively common and accounts for about 25% of primary and secondary syphilis. Tertiary syphilis in HIV-uninfected and HIV-infected patients is vanishingly rare. This is most likely due to early treatment of cases of primary and secondary syphilis. There is rapid progression to tertiary syphilis in HIV-infected patients. Case Presentation: A 49-year-old woman diagnosed with HIV Type 1 infection and cluster of differentiation 4 (CD4) count of 482 presented with a four-week history of multiple crusted plaques, nodules, and ulcers on her face, arms, and abdomen...
2017: Case Reports in Dermatological Medicine
https://www.readbyqxmd.com/read/29225264/a-homozygous-lama2-mutation-of-c-818g-a-caused-partial-merosin-deficiency-in-a-japanese-patient
#4
Akatsuki Kubota, Hiroyuki Ishiura, Jun Mitsui, Kaori Sakuishi, Atsushi Iwata, Tomotaka Yamamoto, Ichizo Nishino, Shoji Tsuji, Jun Shimizu
A complete loss of merosin, which is encoded by LAMA2, causes congenital muscular dystrophy with leukoencephalopathy. Partial merosin deficiency can be caused not only by primarily LAMA2 mutations, but also secondarily by dystroglycanopathy. Although it can be molecularly diagnosed based on a genetic analysis, this method is labor-intensive because of its huge genome size. A 26-year-old male patient presented with mild muscular weakness, joint contractures, and epilepsy. Double immunofluorescence staining of a muscle biopsy specimen showed mislocalization of merosin, and a genetic analysis revealed a homozygous c...
December 8, 2017: Internal Medicine
https://www.readbyqxmd.com/read/29223706/cross-over-clinical-trial-for-evaluating-the-safety-of-camel-s-milk-intake-in-patients-who-are-allergic-to-cow-s-milk-protein
#5
E M Navarrete-Rodríguez, L A Ríos-Villalobos, C R Alcocer-Arreguín, B E Del-Rio-Navarro, J M Del Rio-Chivardi, O J Saucedo-Ramírez, J J L Sienra-Monge, R V Frias
BACKGROUND: Cow's milk protein allergy (CMPA) affects between 0.6 and 0.9% of the general population, and its treatment implies the total elimination of the intake of this protein. Camel's milk has been suggested as an alternative for patients over one year of age who suffer from CMPA due to the difference in the amino acid sequence from that of cow's milk. The objective of this study was to evaluate the safety and tolerability of camel's milk in children with CMPA. METHODS: Crossed clinical trial for the use of camel's milk vs...
December 6, 2017: Allergologia et Immunopathologia
https://www.readbyqxmd.com/read/29221844/gabapentin-as-an-adjuvant-therapy-for-prevention-of-acute-phantom-limb-pain-in-pediatric-patients-undergoing-amputation-for-malignant-bone-tumors-a-prospective-double-blind-randomized-controlled-trial
#6
Xiandi Wang, Ying Yi, Dingbo Tang, Yi Chen, Yanhua Jiang, Jun Peng, Jiwei Xiao
CONTEXT: Gabapentin is reported to have an analgesic effect of reducing phantom-limb pain(PLP) in adult patients. There's no study on preoperative use of gabapentin in pediatric population in term of PLP prevention. OBJECTIVE: To determine whether gabapentin could be used as an adjuvant agent of opioid-based pain control to lower the rate of phantom-limb pain in pediatric patients undergoing amputation for malignant bone tumors in observation period of 60 days post-operatively...
December 5, 2017: Journal of Pain and Symptom Management
https://www.readbyqxmd.com/read/29220753/a-systematic-review-of-the-gait-characteristics-associated-with-cerebellar-ataxia
#7
REVIEW
Ellen Buckley, Claudia Mazzà, Alisdair McNeill
BACKGROUND: Cerebellar Ataxias are a group of gait disorders resulting from dysfunction of the cerebellum, commonly characterised by slowly progressing incoordination that manifests as problems with balance and walking leading to considerable disability. There is increasing acceptance of gait analysis techniques to quantify subtle gait characteristics that are unmeasurable by current clinical methods This systematic review aims to identify the gait characteristics able to differentiate between Cerebellar Ataxia and healthy controls...
December 1, 2017: Gait & Posture
https://www.readbyqxmd.com/read/29216689/-doxycycline-as-an-adjuvant-in-postsurgical-recovery-of-rotator-cuff-injuries-one-year-follow-up
#8
J I Díaz-Sanabria, C Trueba-Vasavilbaso, F Gil-Orbezo, C Trueba-Davalillo, M Acuña-Tovar
BACKGROUND: The severity and progression of rotator cuff tears have forced research on new treatment pathways such as metalloprotease inhibition, which has shown a reduction in healing time and improvement in the structure of collagen fibers. OBJECTIVE: To evaluate the use of doxycycline as a healing enhancer in rotator cuff tears after surgical treatment. MATERIAL AND METHODS: 20 patients were included; they were divided into two groups, 10 with the use of doxycycline and 10 without it after arthroscopic repair with one-year follow-up...
July 2017: Acta Ortopédica Mexicana
https://www.readbyqxmd.com/read/29215494/descriptive-analysis-of-state-and-federal-spine-surgery-malpractice-litigation-in-the-united-states
#9
Nitin Agarwal, Raghav Gupta, Prateek Agarwal, Pravin Matthew, Richard Wolferz Jr, Aakash Shah, Nimer Adeeb, Arpan V Prabhu, Adam S Kanter, David O Okonkwo, D Kojo Hamilton
STUDY DESIGN: Retrospective Review OBJECTIVE.: This study aimed to determine the factors associated with malpractice litigation in cases involving spine surgery in the United States. SUMMARY OF BACKGROUND DATA: Medical malpractice is of substantial interest to the medical community due to concerns of increased healthcare costs and medical decision-making for the sole purpose of reducing legal liability. METHODS: The Westlaw online legal database (Thomson Reuters, New York, NY) was searched for verdict and settlement reports pertaining to spine surgery from 2010 to 2015...
December 5, 2017: Spine
https://www.readbyqxmd.com/read/29212812/pharmacologic-prevention-of-incident-atrial-fibrillation-long-term-results-from-the-allhat-antihypertensive-and-lipid-lowering-treatment-to-prevent-heart-attack-trial
#10
Thomas A Dewland, Elsayed Z Soliman, Jose-Miguel Yamal, Barry R Davis, Alvaro Alonso, Christine M Albert, Lara M Simpson, L Julian Haywood, Gregory M Marcus
BACKGROUND: Although atrial fibrillation (AF) guidelines indicate that pharmacological blockade of the renin-angiotensin system may be considered for primary AF prevention in hypertensive patients, previous studies have yielded conflicting results. We sought to determine whether randomization to lisinopril reduces incident AF or atrial flutter (AFL) compared with chlorthalidone in a large clinical trial cohort with extended post-trial surveillance. METHODS AND RESULTS: We performed a secondary analysis of the ALLHAT (Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial), a randomized, double-blind, active-controlled clinical trial that enrolled hypertensive individuals ≥55 years of age with at least one other cardiovascular risk factor...
December 2017: Circulation. Arrhythmia and Electrophysiology
https://www.readbyqxmd.com/read/29211967/efficacy-and-safety-of-amphetamine-extended-release-oral-suspension-in-children-with-attention-deficit-hyperactivity-disorder
#11
Ann C Childress, Sharon B Wigal, Matthew N Brams, John M Turnbow, Yulia Pincus, Heidi W Belden, Sally A Berry
OBJECTIVES: To determine the efficacy and safety of amphetamine extended-release oral suspension (AMPH EROS) in the treatment of attention-deficit/hyperactivity disorder (ADHD) in a dose-optimized, randomized, double-blind, parallel-group study. METHODS: Boys and girls aged 6 to 12 years diagnosed with ADHD were enrolled. During a 5-week, open-label, dose-optimization phase, patients began treatment with 2.5 or 5 mg/day of AMPH EROS; doses were titrated until an optimal dose (maximum 20 mg/day) was reached...
December 6, 2017: Journal of Child and Adolescent Psychopharmacology
https://www.readbyqxmd.com/read/29210196/ultrasonographic-detection-of-double-contour-sign-and-hyperechoic-aggregates-for-diagnosis-of-gout-two-sites-examination-is-as-good-as-six-sites-examination
#12
Danveer Bhadu, Siddharth K Das, Archana Wakhlu, Urmila Dhakad, Meha Sharma
OBJECTIVE: To compare ultrasound-detected abnormalities, namely double contour sign (DCS) and hyperechoic aggregates (HAGs), at two sites (knee and first metatarsophalangeal [1st MTP] joints) versus six sites (knee joint, 1st MTP joint, radiocarpal joint, talar joint, patellar tendon and triceps tendon) in gout patients. METHODS: Forty-seven clinically diagnosed gout patients and 50 subjects (serum uric acid < 7 mg/dL) as controls were included. DCS was looked for at three articular cartilage sites (first metatarsal, tibiotalar and femoral condyle), whereas HAGs were looked for at one joint site (radiocarpal joint) and two tendon sites (patellar tendon and triceps tendon)...
December 5, 2017: International Journal of Rheumatic Diseases
https://www.readbyqxmd.com/read/29209867/non-specific-effects-and-clusters-of-women-with-painful-tmd-responders-and-non-responders-to-lllt-double-blind-randomized-clinical-trial
#13
Laís Valencise Magri, Vinícius Almeida Carvalho, Flávia Cássia Cabral Rodrigues, César Bataglion, Christie Ramos Andrade Leite-Panissi
The aim was to analyze the non-specific effects (placebo, spontaneous remission, and regression to the mean) of the low-level laser therapy (LLLT) in women with myofascial pain (painful temporomandibular disorder (TMD)), as well as to differentiate between responders and non-responder clusters to active and placebo LLLT according to the anxiety levels, salivary cortisol, use of oral contraceptives, and premenstrual period. Sixty-four women diagnosed with myofascial pain (Research Diagnostic Criteria for Temporomandibular Disorders (RDC/TMD)) were included, divided into laser (n = 20), placebo group (n = 21), and 23 controls (without treatment (WT))...
December 5, 2017: Lasers in Medical Science
https://www.readbyqxmd.com/read/29209514/fish-oil-supplementation-in-chronic-obstructive-pulmonary-disease-feasibility-of-conducting-a-randomised-controlled-trial
#14
Ashley S Fulton, Alison M Coates, Marie T Williams, Peter R C Howe, Manohar L Garg, Lisa G Wood, Peter Frith, Alison M Hill
Background: Long-chain omega-3 polyunsaturated fatty acids (LCn-3PUFAs) may act as an effective adjunct therapy for chronic obstructive pulmonary disease (COPD), a condition characterised by persistent airflow limitation and inflammation. However, the nature of this illness presents challenges for evaluating potential benefits. The aim of this study was to determine the feasibility of undertaking a randomised controlled trial of LCn-3PUFA supplementation in adults with COPD. Methods: A 16-week parallel, double-blind, randomised, placebo-controlled dietary supplementation trial was conducted...
2017: Pilot and Feasibility Studies
https://www.readbyqxmd.com/read/29209135/first-case-of-cross-auxiliary-double-domino-donor-liver-transplantation
#15
Zhi-Jun Zhu, Lin Wei, Wei Qu, Li-Ying Sun, Ying Liu, Zhi-Gui Zeng, Liang Zhang, En-Hui He, Hai-Ming Zhang, Ji-Dong Jia, Zhong-Tao Zhang
We report a case of double domino liver transplantation in a 32-year-old woman who was diagnosed with familial amyloid polyneuropathy (FAP) and liver dysfunction. A two-stage surgical plan was designed, and one domino graft was implanted during each stage. During the first stage, an auxiliary domino liver transplantation was conducted using a domino graft from a 4-year-old female child with Wilson's disease. After removing the right lobe of the FAP patient's liver, the graft was rotated 90 degrees counterclockwise and placed along the right side of the inferior vena cava (IVC)...
November 28, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/29208881/clinicopathological-assessment-of-colorectal-carcinoma-in-mymensingh-medical-college-hospital-bangladesh
#16
M M Mahamud, F Wahed, J Ferdous, M K Khan
Colorectal carcinoma (CRC) is the third most commonly diagnosed cancer and the third leading cause of cancer death in both men and women in the US. It is mainly a disease of the developed countries with a western culture, yet the disease is not uncommon in developing countries. There is substantial geographical variation in the incidence and demographic characteristics of the disease. Variations are also observed in the risk factors, mode of presentation, sub site distribution and stage of the disease at presentation...
October 2017: Mymensingh Medical Journal: MMJ
https://www.readbyqxmd.com/read/29206577/increased-reporting-of-exclusionary-diagnoses-inflate-apparent-reductions-in-long-stay-antipsychotic-prescribing
#17
Jonathan D Winter, J William Kerns, Katherine M Winter, Roy T Sabo
OBJECTIVE: Over the two years following the 2012 introduction of CMS's National Partnership, combined rates of schizophrenia, Tourette's, and Huntington's in US long-stay residents increased 12%. We evaluated trends in reporting of these diagnoses for the subgroup of long-stay residents on antipsychotics. METHODS: Retrospective analysis of Virginia Medicaid claims identified annual utilization rates of psychiatric diagnoses for long-stay seniors on antipsychotics...
October 24, 2017: Clinical Gerontologist
https://www.readbyqxmd.com/read/29206281/giant-cell-tumours-of-bone-treated-with-denosumab-histologic-immunohistochemical-and-h3f3a-mutation-analyses
#18
Ikuma Kato, Mitsuko Furuya, Kosuke Matsuo, Yusuke Kawabata, Reiko Tanaka, Kenichi Ohashi
AIMS: Denosumab, a human monoclonal antibody directed against the receptor activator of nuclear factor-kappa B ligand (RANKL), is a therapeutic agent for giant cell tumour of bone (GCTB). Although some studies reported that denosumab shrinks tumours and induces bone formation, the actual effects of RANKL suppression on GCTB remain unclear. A mutation in the H3 histone family member 3A gene (H3F3A) was recently identified as a genetic signature for GCTB. The aim of this study was to investigate the histopathological features and H3F3A mutation status of GCTBs treated with denosumab...
December 5, 2017: Histopathology
https://www.readbyqxmd.com/read/29203892/metabolic-syndrome-and-smoking-are-associated-with-an-increased-risk-of-nocturia-in-male-patients-with-benign-prostatic-enlargement
#19
Cosimo De Nunzio, Aldo Brassetti, Flavia Proietti, Marianna Deroma, Francesco Esperto, Andrea Tubaro
BACKGROUND: To evaluate the relationship between cigarette smoking, metabolic syndrome (MetS) and nocturia in patients with lower urinary tract symptoms (LUTS) and benign prostatic enlargement (BPE). METHODS: From 2009 onward, a consecutive series of patients with LUTS/BPE were enrolled. Symptoms were assessed using the International Prostate Symptom Score (IPSS). Age, body mass index (BMI), smoker status, prostate volume (PV), prostate-specific antigen (PSA) levels, fasting glucose levels, triglyceride levels, and high-density lipoprotein levels were recorded...
December 4, 2017: Prostate Cancer and Prostatic Diseases
https://www.readbyqxmd.com/read/29202217/dna-modulates-the-interaction-of-genetically-engineered-dna-binding-proteins-and-gold-nanoparticles-diagnosis-of-high-risk-hpv-infection
#20
Ju-Yi Mao, Han-Wei Li, Shih-Chun Wei, Scott G Harroun, Ming-Ying Lee, Hung-Yun Lin, Chih-Yu Chung, Chun-Hua Hsu, Yet-Ran Chen, Han-Jia Lin, Chih-Ching Huang
Gene detection has an important role in diagnosing several serious diseases and genetic defects in modern clinical medicine. Herein, we report a fast and convenient gene detection method based on the modulation of the interaction between a heat-resistant double-stranded DNA (dsDNA)-binding protein (Sso7d) and gold nanoparticles (Au NPs). We prepared a recombinant Cys-Sso7d, which is Sso7d with an extra cysteine (Cys) residue in the N-terminus, through protein engineering to control the interaction between Sso7d and Au NPs...
December 4, 2017: ACS Applied Materials & Interfaces
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