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EBV Lymph Node

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https://www.readbyqxmd.com/read/28814970/prevalence-and-characteristics-of-epstein-barr-virus-associated-gastric-carcinomas-in-portugal
#1
Célia Nogueira, Marta Mota, Rui Gradiz, Maria Augusta Cipriano, Francisco Caramelo, Hugo Cruz, Ana Alarcão, Francisco Castro E Sousa, Fernando Oliveira, Fernando Martinho, João Moura Pereira, Paulo Figueiredo, Maximino Leitão
BACKGROUND: Gastric cancer (GC) is one of the most common malignant tumors of the digestive tract and is the third leading cause of cancer death worldwide. Epstein-Barr virus (EBV) has been associated with approximately 10% of the total cases of gastric carcinomas. No previous study has analyzed the prevalence of EBV infection in gastric cancer of the Portuguese population. METHODS: In the present study, we have analyzed 82 gastric carcinoma cases and 33 healthy individuals (control group) from Coimbra region for the presence of EBV by polymerase chain reaction (PCR) and by in situ hybridization (ISH) for EBV-encoded small RNAs (EBERs)...
2017: Infectious Agents and Cancer
https://www.readbyqxmd.com/read/28800008/epstein-barr-virus-infection-can-be-a-secondary-event-in-b-cell-lymphomas-a-review-of-338-cases-and-a-novel-finding-of-zonal-eber-tumor-cells-showing-features-of-progression-from-underlying-ebv-negative-lymphoma
#2
Ira J Miller
Cases of B-cell lymphoma over an 8-year interval with diagnosis of EBER positivity were retrieved from archives and reviewed for classification and pattern of Epstein Barr Virus (EBV) expression. Of 46 cases that were EBV early RNA (EBER)+ by in situ hybridization staining, 7 had nonuniform staining among the neoplastic cells. Four of those cases showed a uniform admixture of EBER+ and EBER- tumor cells, compatible with the prevailing theory of episomal EBV loss with cell replication. Three cases of lymphomas showed a partial and zonal pattern and other features suggest that EBV infection occurred after the lymphoma was already established...
August 9, 2017: Applied Immunohistochemistry & Molecular Morphology: AIMM
https://www.readbyqxmd.com/read/28796808/pd-l1-and-gastric-cancer-prognosis-a-systematic-review-and-meta-analysis
#3
Lihu Gu, Manman Chen, Dongyu Guo, Hepan Zhu, Wenchao Zhang, Junhai Pan, Xin Zhong, Xinlong Li, Haoran Qian, Xianfa Wang
The expression of Programmed cell Death Ligand 1 (PD-L1) is observed in many malignant tumors and is associated with poor prognosis including Gastric Cancer (GC). The relationship between PD-L1 expression and prognosis, however, is controversial in GC. This paper purports to use a meta-analysis to investigate the relationship between PD-L1 expression and prognosis in GC. For this study, the following databases were searched for articles published from June 2003 until February 2017: PubMed, EBSCO, Web of Science and Cochrane Library...
2017: PloS One
https://www.readbyqxmd.com/read/28754096/successful-treatment-with-anti-programmed-death-1-antibody-in-a-relapsed-natural-killer-t-cell-lymphoma-patient-with-multi-line-resistance-a-case-report
#4
Jianping Lai, Peng Xu, Xiaoliu Jiang, Shan Zhou, Anwen Liu
BACKGROUND: Extranodal natural killer/T-cell lymphoma (NKTCL), nasal type, is an aggressive malignancy with poor prognosis. Currently, there is no recommended standard therapy for relapsed NKTCL. CASE PRESENTATION: A 37-year-old woman with lymphadenopathy was diagnosed with NKTCL by biopsy of an enlarged lymph node on the right side of her neck. Enhanced computed tomography revealed no metastasis. For this patient, we performed continuous chemotherapy followed by radiotherapy; however, nodule biopsy showed metastases in her lower limbs 3 months after radiotherapy, which confirmed disease progression...
July 28, 2017: BMC Cancer
https://www.readbyqxmd.com/read/28712702/clinical-usefulness-of-f-18-fdg-pet-in-lymphoepithelioma-like-gastric-carcinoma
#5
Soyeon Park, Dakeun Lee, Kee Myung Lee, Sang-Uk Han, Jei Hee Lee, Su Jin Lee, Young-Sil An, Joon-Kee Yoon
PURPOSE: Lymphoepithelioma-like carcinoma (LELC) is a rare type of gastric cancer. We evaluated the clinical usefulness of F-18 FDG positron emission tomography/computed tomography (PET/CT) in LELC of stomach. MATERIALS AND METHODS: A total of 28 patients (mean age=59years) who underwent preoperative F-18 FDG PET/CT were enrolled retrospectively. Nine patients underwent follow-up F-18 FDG PET/CT. Pathologic information was obtained through gastrectomy and the association with Epstein-Barr virus (EBV) was investigated in 26 patients...
June 27, 2017: European Journal of Radiology
https://www.readbyqxmd.com/read/28712115/expression-of-interferon-regulatory-factor-7-correlates-with-the-expression-of-epstein-barr-virus-latent-membrane-protein-1-and-cervical-lymph-node-metastasis-in-nasopharyngeal-cancer
#6
Satoru Kondo, Kazuhira Endo, Naohiro Wakisaka, Mitsuharu Aga, Makoto Kano, Noriko Seishima, Tomoko Imoto, Eiji Kobayashi, Makiko Moriyama-Kita, Yosuke Nakanishi, Shigeyuki Murono, Joseph S Pagano, Tomokazu Yoshizaki
Interferon regulatory factor 7 (IRF7) has oncogenic properties in several malignancies such as Epstein-Barr virus (EBV)-associated lymphoma. However, there is no evidence whether IRF7 is associated with the oncogenesis of nasopharyngeal cancer (NPC), the pathogenesis of which is closely associated with EBV. Herein, we report that expression of IRF7 was increased in normal nasopharyngeal cells that expressed the EBV principal oncoprotein, latent membrane protein 1 (LMP1). In addition, IRF7 was mainly expressed in the nucleus in both normal nasopharyngeal cells and nasopharyngeal cancer cells that expresses LMP1...
July 16, 2017: Pathology International
https://www.readbyqxmd.com/read/28597982/a-rare-case-of-epstein-barr-virus-associated-early-gastric-cancer-with-multiple-synchronous-intramucosal-lesions
#7
Katsuyuki Murai, Naomi Kakushima, Kimihide Kusafuka
Epstein-Barr virus-associated gastric cancer (EBV-GC) accounts for 8.7% of gastric cancer.(1) EBV-GC is associated with lower prevalence of lymph node metastasis (LNM), and better prognosis.(1-3) However, little is known regarding intramucosal EBV-GC. We report a case of multiple synchronous lesions of intramucosal EBV-GC. This article is protected by copyright. All rights reserved.
June 9, 2017: Digestive Endoscopy: Official Journal of the Japan Gastroenterological Endoscopy Society
https://www.readbyqxmd.com/read/28584793/clinical-significance-of-p53-protein-expression-beta-catenin-expression-and-her2-expression-for-epstein-barr-virus-associated-gastric-cancer
#8
Dong Won Baek, Byung Woog Kang, Soyoon Hwang, Jong Gwang Kim, An Na Seo, Han Ik Bae, Oh Kyoung Kwon, Seung Soo Lee, Ho Young Chung, Wansik Yu
This study assessed the expression of the p53 protein, beta-catenin, and HER2 and their prognostic implications in patients with EBV-associated gastric cancer (EBVaGC). After reviewing 1318 consecutive cases of surgically resected or endoscopic submucosal dissected gastric cancers, 117 patients were identified as EBV-positive using EBV-encoded RNA in-situ hybridization. The immunohistochemistry results were interpreted as follows: strong p53 nuclear expression in at least 50% of tumor nuclei was interpreted as a positive result, strong beta-catenin expression in at least 10% of cytoplasmic nuclei was interpreted as a positive result, and moderate or strong complete or basolateral membrane staining in 10% of tumor cells was interpreted as a positive result for HER2...
May 2017: Chonnam Medical Journal
https://www.readbyqxmd.com/read/28559386/role-of-sdf-1%C3%AE-cxcr4-signaling-pathway-in-clinicopathological-features-and-prognosis-of-patients-with-nasopharyngeal-carcinoma
#9
Yun-Ling Li, Yu-Fen Li, Hua-Feng Li, Huai-Qing Lv, De-Zhong Sun
The study aims to explore the role of stromal cell derived factor-1α (SDF-1α)/stromal cell derived factor receptor-4 (CXCR4) signaling pathway to the clinicopathological features and prognosis of patients with nasopharyngeal carcinoma (NPC). From January 2009 to December 2010, 102 patients with NPC and 80 patients with chronic nasopharyngitis were enrolled for the study. Immunohistochemical staining, qRT-PCR and Western blotting were employed to determine the expressions of SDF-1α and CXCR4 proteins in NPC tissues and chronic nasopharyngitis tissues...
May 30, 2017: Bioscience Reports
https://www.readbyqxmd.com/read/28552534/an-epstein-barr-virus-positive-classical-hodgkin-lymphoma-with-exclusive-sinusoidal-growth-pattern-an-unusual-morphologic-variant
#10
Pu Su, Rachel Jug, Xin Liu, Endi Wang
Classical Hodgkin lymphoma (cHL) typically involves lymph node parenchyma, and a case with Hodgkin cells confined within nodal sinusoids is extremely rare. Herein we report a case of cHL with a sinusoidal growth pattern. This 15-year old patient presented with B symptoms and was found to have bilateral cervical lymphadenopathy and an anterior mediastinal mass. Biopsy of a cervical lymph node demonstrated cohesive clusters of Reed-Sternberg (RS)-like cells suggestive of sinusoidal growth with an extrasinusoidal mixed inflammatory cell infiltrate characteristic of the microenvironment seen in cHL...
June 2017: Pathology, Research and Practice
https://www.readbyqxmd.com/read/28548121/ebv-negative-aggressive-nk-cell-leukemia-lymphoma-a-clinical-and-pathological-study-from-a-single-institution
#11
Juehua Gao, Amir Behdad, Peng Ji, Kristy L Wolniak, Olga Frankfurt, Yi-Hua Chen
Aggressive natural killer (NK)-cell leukemia/lymphoma is a systemic NK-cell neoplasm that preferentially affects Asians with a fulminant clinical course and is almost always associated with Epstein-Barr virus (EBV). The data on EBV-negative aggressive NK-cell leukemia/lymphoma are limited. Here we report a series of three patients (two Caucasians, one African-American) with EBV-negative aggressive NK-cell leukemia/lymphoma from a single institution, including a case diagnosed on post-mortem examination. Similar to EBV-positive aggressive NK-cell leukemia/lymphoma, our patients presented with constitutional symptoms and hepatosplenomegaly, and followed a highly aggressive clinical course...
May 26, 2017: Modern Pathology: An Official Journal of the United States and Canadian Academy of Pathology, Inc
https://www.readbyqxmd.com/read/28457323/lymphoepithelioma-like-gastric-carcinoma-clinicopathological-characteristics-and-infection-status
#12
Marcus Fernando Kodama Pertille Ramos, Marina Alessandra Pereira, Andre Roncon Dias, Sheila Friedrich Faraj, Bruno Zilberstein, Ivan Cecconello, Evandro Sobroza de Mello, Ulysses Ribeiro Junior
BACKGROUND: Lymphoepithelioma-like gastric carcinoma (LLGC) is a rare subtype of gastric carcinoma (GC) characterized by prominent lymphocytic infiltration. LLGC may be associated with latent Epstein-Barr virus (EBV) infection or microsatellite instability (MSI). This study aims to assess the clinicopathological characteristics, EBV infection, and MSI status in LLGC. METHODS: A retrospective analysis of GC patients submitted to potentially curative resection between 2009 and 2014 was performed...
April 2017: Journal of Surgical Research
https://www.readbyqxmd.com/read/28453696/epstein-barr-virus-associated-gastric-cancer-reveals-intratumoral-heterogeneity-of-pik3ca-mutations
#13
C Böger, S Krüger, H M Behrens, S Bock, J Haag, H Kalthoff, C Röcken
Background: Recent whole-genome sequencing identified four molecular subtypes of gastric cancer (GC), of which the subgroup of Epstein-Barr virus-associated GC (EBVaGC) showed a significant enrichment of PIK3CA mutations. We here aimed to validate independently the enrichment of PIK3CA mutations in EBVaGC of a Central European GC cohort, to correlate EBV status with clinico-pathological patient characteristics and to test for a major issue of GC, intratumoral heterogeneity. Patients and methods: In a first step, 484 GCs were screened for EBV and PIK3CA hot spot mutations of exon 9/20 using EBER in situ hybridization and pyrosequencing, respectively...
May 1, 2017: Annals of Oncology: Official Journal of the European Society for Medical Oncology
https://www.readbyqxmd.com/read/28436953/disruption-of-direct-3d-telomere-trf2-interaction-through-two-molecularly-disparate-mechanisms-is-a-hallmark-of-primary-hodgkin-and-reed-sternberg-cells
#14
Hans Knecht, Nathalie A Johnson, Tina Haliotis, Daniel Lichtensztejn, Sabine Mai
In classical Hodgkin's lymphoma (cHL), specific changes in the 3D telomere organization cause progression from mononuclear Hodgkin cells (H) to multinucleated Reed-Sternberg cells (RS). In a post-germinal center B-cell in vitro model, permanent latent membrane protein 1 (LMP1) expression, as observed in Epstein-Barr virus (EBV)-associated cHL, results in multinuclearity and complex chromosomal aberrations through downregulation of key element of the shelterin complex, the telomere repeat binding factor 2 (TRF2)...
April 24, 2017: Laboratory Investigation; a Journal of Technical Methods and Pathology
https://www.readbyqxmd.com/read/28280640/hhv8-ebv-coinfection-lymphoproliferative-disorder-rare-entity-with-a-favorable-outcome
#15
Dhouha Bacha, Beya Chelly, Houda Kilani, Lamia Charfi, Amel Douggaz, Samia Chatti, Emna Chelbi
HHV8/EBV-associated germinotropic lymphoproliferative disorder (GLD) is a challenging diagnosis given its rarity, the particular clinical presentation, and the lack of expression of markers usually used in establishing hematopoietic lineage. We report a new case of HHV8/EBV GLD in an immunocompetent 78-year-old woman. The diagnosis was made in an incidentally discovered lymphadenopathy. Histological examination showed a nodular lymphoid proliferation centered by aggregates of atypical plasmablastic cells admixed with small lymphoid cells...
2017: Case Reports in Hematology
https://www.readbyqxmd.com/read/28248818/kshv-associated-and-ebv-associated-germinotropic-lymphoproliferative-disorder-new-findings-and-review-of-the-literature
#16
Tapan Bhavsar, John C Lee, Yvonne Perner, Mark Raffeld, Liqiang Xi, Stefania Pittaluga, Elaine S Jaffe
We report 2 cases of Kaposi sarcoma-associated herpesvirus (KSHV)-and Epstein-Barr Virus (EBV) associated germinotropic lymphoproliferative disorder. Both cases arose in patients from regions endemic for KSHV, Cape Verde, and the Democratic Republic of the Congo, presenting as localized lymphadenopathy. The affected lymph nodes showed colonization of the follicles by clusters of large atypical plasmablasts, but also showed regressive changes with vascular proliferation and interfollicular plasmacytosis, both reminiscent of human herpesvirus 8 (HHV-8) positive multicentric Castleman disease...
June 2017: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/28247228/update-from-the-4th-edition-of-the-world-health-organization-classification-of-head-and-neck-tumours-what-is-new-in-the-2017-who-blue-book-for-tumors-and-tumor-like-lesions-of-the-neck-and-lymph-nodes
#17
Nora Katabi, James S Lewis
The World Health Organization (WHO) 2017 Classification of Head and Neck Tumors ("Blue Book") will now include a new chapter on tumors and tumor-like lesions of the neck and lymph nodes, which was not included in the previous edition. Tumors and tumor-like lesions, including a variety of cysts and metastases, can arise in any component in the neck, including soft tissue, lymph nodes, and developmental remnants. The pathology and clinical features of metastatic carcinoma of unknown primary in the head and neck has changed dramatically in the last several years...
March 2017: Head and Neck Pathology
https://www.readbyqxmd.com/read/28243437/analysis-of-the-cross-talk-of-epstein-barr-virus-infected-b-cells-with-t-cells-in-the-marmoset
#18
Jordon Dunham, Nikki van Driel, Bart Jl Eggen, Chaitali Paul, Bert A 't Hart, Jon D Laman, Yolanda S Kap
Despite the well-known association of Epstein-Barr virus (EBV), a lymphocryptovirus (LCV), with multiple sclerosis, a clear pathogenic role for disease progression has not been established. The translationally relevant experimental autoimmune encephalomyelitis (EAE) model in marmoset monkeys revealed that LCV-infected B cells have a central pathogenic role in the activation of T cells that drive EAE progression. We hypothesized that LCV-infected B cells induce T-cell functions relevant for EAE progression. In the current study, we examined the ex vivo cross-talk between lymph node mononuclear cells (MNCs) from EAE marmosets and (semi-) autologous EBV-infected B-lymphoblastoid cell lines (B-LCLs)...
February 2017: Clinical & Translational Immunology
https://www.readbyqxmd.com/read/28215641/coexistence-of-age-related-ebv-associated-follicular-hyperplasia-and-large-b-cell-ebv-lymphoma-of-the-elderly-two-distinct-features-of-the-same-t-cell-dysfunction-related-to-senescence
#19
Jean-Baptiste Gibier, Brigitte Bouchindhomme, Romain Dubois, Benedicte Hivert, Nathalie Grardel, Marie-Christine Copin
Age-related EBV-associated lymphoproliferative disorders form a new clinicopathological group. Until recently, this group was associated with diffuse large B-cell lymphoma (DLBCL), characterised by an aggressive clinical presentation and a poor prognosis. Recent findings in Western Caucasian patients, however, suggest that this entity covers a wide spectrum of diseases, ranging from reactive follicular hyperplasia (HR) to DLBCL. We report the case of an 85-year-old Caucasian man showing lymphadenopathy and numerous hypodense lesions of the liver...
March 2017: Pathology, Research and Practice
https://www.readbyqxmd.com/read/28205059/clinical-application-of-early-gastric-carcinoma-with-lymphoid-stroma-based-on-lymph-node-metastasis-status
#20
Hyun Lim, In Seob Lee, Jeong Hoon Lee, Young Soo Park, Hyo Jeong Kang, Hee Kyong Na, Ji Yong Ahn, Do Hoon Kim, Kee Don Choi, Ho June Song, Gin Hyug Lee, Hwoon-Yong Jung, Jin-Ho Kim, Beom Su Kim, Jeong Hwan Yook, Byung Sik Kim
BACKGROUND: Gastric carcinoma with lymphoid stroma (GCLS) is characterized by undifferentiated carcinoma mixed with prominent lymphoid infiltration. GCLS has unique clinicopathological features and a better prognosis compared to other types of gastric cancer. We analyzed the clinicopathological features of early GCLS in relation to lymph node metastasis (LNM). METHODS: We performed a retrospective analysis of 241 patients diagnosed with GCLS confined to the mucosa or the submucosa between March 1998 and December 2015...
February 15, 2017: Gastric Cancer
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