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EBV Lymph Node

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https://www.readbyqxmd.com/read/29215415/epstein-barr-virus-associated-hemophagocytic-lymphohistiocytosis-mimicking-lymphoma-on-fdg-pet-ct
#1
Qingqing Pan, Yaping Luo, Huanwen Wu, Yanru Ma, Fang Li
A 15-year-old boy with fever, pancytopenia, and hepatosplenomegaly was diagnosed as hemophagocytic lymphohistiocytosis (HLH). F-FDG PET/CT showed hypermetabolic foci in the liver, spleen, and bone marrow, as well as multiple FDG-avid lymph nodes, which were highly suggestive of lymphoma. Specimens from splenectomy depicted a large number of macrophages/histiocytes with hemophagocytosis of erythrocytes, without evidence of malignancy. Considering increased Epstein-Barr virus (EBV) DNA in peripheral blood and positive staining for EBV-encoded RNA in the spleen, EBV-associated HLH was confirmed...
December 5, 2017: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/29200172/a-rare-case-of-chronic-active-epstein-barr-virus-ebv-infection-accompanied-by-the-infiltration-of-ebv-infected-cd8-t-cells-into-the-muscle
#2
Nobuhiko Kobayashi, Takeki Mitsui, Yoshiyuki Ogawa, Hirono Iriuchishima, Makiko Takizawa, Akihiko Yokohama, Takayuki Saitoh, Hiromi Koiso, Norifumi Tsukamoto, Hirokazu Murakami, Yoshihisa Nojima, Hiroshi Handa
We describe a rare case of chronic active Epstein-Barr virus (CAEBV) infection, with infiltration of the skeletal muscle. A 19-year-old woman with swollen cervical lymph nodes and a fever was referred to our hospital. Swelling of the trapezium muscle and elevation of creatinine kinase level were observed. Biopsy results of the brachialis muscle revealed infiltration of Epstein-Barr virus (EBV)-encoded RNA-positive CD8 T lymphocytes. The EBV virus load in the peripheral blood was high, and EBV monoclonality was determined by Southern blot analysis...
December 1, 2017: Journal of Pediatric Hematology/oncology
https://www.readbyqxmd.com/read/29198143/ebv-hhv-8-multicentric-castleman-disease-with-plasmablastic-aggregates-in-an-hiv-man-an-evolving-clinicopathologic-entity
#3
Aditya Shivane, Amy Pearce, Nadia Khatib, Mark E F Smith
We report a case of EBV+ and HHV-8+ multicentric Castleman disease with plasmablastic aggregates in an HIV-positive individual. A 41-year-old man presented in early 2015 with fevers, sweats, weight loss, intractable itching, and on subsequent testing was found to be HIV positive. Investigations showed cervical lymphadenopathy and splenomegaly. He was treated for HIV and his symptoms resolved. His symptoms recurred in January 2016, and a provisional diagnosis of multicentric Castleman disease was entertained...
December 1, 2017: International Journal of Surgical Pathology
https://www.readbyqxmd.com/read/29174725/epstein-barr-virus-ebv-associated-reactive-and-indeterminate-lymphoid-proliferations-in-the-lymph-node
#4
REVIEW
Nadine Aguilera, Aaron Auerbach
No abstract text is available yet for this article.
November 15, 2017: Seminars in Diagnostic Pathology
https://www.readbyqxmd.com/read/29164473/clinicopathological-and-immunohistochemical-study-of-head-and-neck-langerhans-cell-histiocytosis-from-latin-america
#5
Natália Rocha Bedran, Román Carlos, Bruno Augusto Benevenuto de Andrade, Ana Paula Silva Bueno, Mário José Romañach, Cristiane Bedran Milito
Langerhans cell histiocytosis (LCH) is an inflammatory myeloid neoplastic proliferation with variable clinical behavior caused by the accumulation of CD1a(+)/CD207(+) histiocytes, associated with a variable number of eosinophils, lymphocytes, plasma cells and multinucleated giant cells, most commonly observed in male children. LCH is uncommon in the head and neck region, occurring as ulcerated and reddened plaques or nodules that cause destruction of adjacent soft tissues and bone. The exact etiology of LCH is still unknown and controversial, with possible etiologic role of viruses, including Epstein-Barr virus (EBV)...
November 21, 2017: Head and Neck Pathology
https://www.readbyqxmd.com/read/29142476/clinical-and-pathological-characterization-of-epstein-barr-virus-associated-gastric-carcinomas-in-portugal
#6
Joana Ribeiro, Andreia Oliveira, Mariana Malta, Claudia Oliveira, Fernanda Silva, Ana Galaghar, Luís Pedro Afonso, Maria Cassiano Neves, Rui Medeiros, Pedro Pimentel-Nunes, Hugo Sousa
AIM: To determine the prevalence of Epstein-Barr virus (EBV)-associated gastric carcinomas in the North Region of Portugal and to study its clinicopathological characteristics. METHODS: We have performed a retrospective study including a total of 179 consecutive patients with gastric cancer (GC) submitted to gastrectomy during 2011 at the Portuguese Oncology Institute of Porto. Clinical and pathological data was collected from individual clinical records and inserted on a database with unique codification...
October 28, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/29112016/b-lymphoblastic-leukemia-lymphoma-with-burkitt-like-morphology-and-igh-myc-rearrangement-report-of-3-cases-in-adult-patients
#7
Yiting Li, Gunjan Gupta, Ari Molofsky, Yi Xie, Nader Shihabi, Jane McCormick, Elaine S Jaffe
Isolated MYC rearrangement without other recurrent genetic abnormalities is rare in B lymphoblastic leukemia/lymphoma (B-ALL/LBL), with most cases reported in pediatric patients. We report 3 adult cases with lymphoblasts showing a precursor B cell immunophenotype, and isolated MYC/IGH translocation. All 3 cases occurred in male patients with initial presentation of diffuse lymphadenopathy. Cases 1 and 2 had B-ALL with significantly increased lymphoblasts in peripheral blood and bone marrow. Case 3, a patient with human immunodeficiency virus infection, had the diagnosis of B-LBL made on a retroperitoneal lymph node biopsy and had no peripheral blood or bone marrow involvement...
November 3, 2017: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/29073638/intratumoural-pd-l1-expression-is-associated-with-worse-survival-of-patients-with-epstein-barr-virus-associated-gastric-cancer
#8
An Na Seo, Byung Woog Kang, Oh Kyoung Kwon, Ki Bum Park, Seung Soo Lee, Ho Young Chung, Wansik Yu, Han Ik Bae, Seong Woo Jeon, Hyojeung Kang, Jong Gwang Kim
BACKGROUND: This study investigated the clinical relevance and prognostic impact of the overall expression of programmed cell death protein ligand-1 (PD-L1) and programmed cell death protein ligand-2 (PD-L2), in patients with Epstein-Barr virus-associated gastric cancer (EBVaGC). METHODS: After reviewing 1318 consecutive cases of surgically resected or endoscopic submucosal dissected gastric cancers, the expression status of PD-L1 and PD-L2 in 120 patients with EBVaGC identified by EBV-encoded RNA in situ hybridisation was retrospectively analysed using immunohistochemistry (IHC)...
December 5, 2017: British Journal of Cancer
https://www.readbyqxmd.com/read/29050074/-clinicopathologic-characteristics-and-prognosis-of-neoplastic-cell-rich-mixed-cellularity-classic-hodgkin-lymphoma
#9
W H Hou, P Wei, J L Xie, Y Y Zheng, X G Zhou
Objective: To investigate the clinicopathologic characteristics of neoplastic cell-rich mixed cellularity classical Hodgkin lymphoma(MCCHL-R) and to compare the prognosis with typical mixed cellularity classic Hodgkin lymphoma(MCCHL). Methods: Fifty-four patients with MCCHL-R(the tumor cells >10%) and 65 patients with typical MCCHL identified from 1 721 Hodgkin lymphomas were reviewed to compare the clinicopathological characteristics including morphologic and immunophenotypic features, EBV infection status, clinical therapy and overall survival...
October 8, 2017: Zhonghua Bing Li Xue za Zhi Chinese Journal of Pathology
https://www.readbyqxmd.com/read/28985762/a-study-of-epstein-barr-virus-infection-in-the-chinese-tree-shrew-tupaia-belangeri-chinensis
#10
Zhi Wang, Xiang Yi, Long Du, Hong Wang, Jie Tang, Menglin Wang, Chenglin Qi, Heng Li, Yongjing Lai, Wei Xia, Anzhou Tang
BACKGROUND: Epstein-Barr virus (EBV) is closely associated with many human diseases, including a variety of deadly human malignant tumours. However, due to the lack of ideal animal models,the biological characteristics of EBV, particularly its function in tumourigenesis, have not been determined. Chinese tree shrews (Tupaia belangeri chinensis), which are similar to primates, have been used to establish a variety of animal models and have recently received much attention. Here, we established tree shrews as a model for EBV infection by intravenous injection...
October 6, 2017: Virology Journal
https://www.readbyqxmd.com/read/28945625/expression-of-tfh-markers-and-detection-of-rhoa-p-g17v-and-idh2-p-r172k-s-mutations-in-cutaneous-localizations-of-angioimmunoblastic-t-cell-lymphomas
#11
Ariane Leclaire Alirkilicarslan, Aurélie Dupuy, Anaïs Pujals, Marie Parrens, Béatrice Vergier, Alistair Robson, Marie-Hélène Delfau-Larue, Saskia Ingen-Housz-Oro, Olivier Chosidow, Corinne Haioun, Marie Beylot-Barry, Jean-Philippe Merlio, Christiane Copie-Bergman, Philippe Gaulard, Nicolas Ortonne
Skin biopsies of 41 angioimmunoblastic T-cell lymphoma patients were retrospectively analyzed for the expression of follicular helper T-cell (TFH) markers, Epstein-Barr virus (EBV), and the presence of RHOA (p.G17V) and IDH2 (p.R172K/S) mutations using allele-specific polymerase chain reaction. We categorized cases into 4 distinctive patterns: (1) low-density lymphocytic perivascular infiltrates (n=11), (2) dense perivascular infiltrates with atypical cells and occasional inflammatory cells (n=13), (3) diffuse infiltrates reminiscent of angioimmunoblastic T-cell lymphoma (n=4), or (4) other aspects (n=13)...
December 2017: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/28937020/unique-characteristics-of-arid1a-mutation-and-protein-level-in-gastric-and-colorectal-cancer-a-meta-analysis
#12
REVIEW
Young-Sik Kim, Hoiseon Jeong, Jung-Woo Choi, Hwa Eun Oh, Ju-Han Lee
BACKGROUND/AIM: Recently, AT-rich interactive domain-containing 1A protein (ARID1A) has been identified as a novel tumor suppressor gene in gastric cancer (GC) and colorectal cancer (CRC). However, the clinicopathologic value of ARID1A mutation or protein level in GC and CRC patients is controversial. Hence, we conducted a meta-analysis on the relationship between ARID1A aberrations and clinicopathologic parameters in GC and CRC. MATERIALS AND METHODS: Relevant published studies were selected from PubMed and EMBASE...
September 2017: Saudi Journal of Gastroenterology: Official Journal of the Saudi Gastroenterology Association
https://www.readbyqxmd.com/read/28903550/combination-of-tumor-volume-and-epstein-barr-virus-dna-improved-prognostic-stratification-of-stage-ii-nasopharyngeal-carcinoma-in-the-imrt-era-a-large-scale-cohort-study
#13
Qiu-Yan Chen, Shao-Yan Guo, Lin-Quan Tang, Tong-Yu Lu, Bo-Lin Chen, Qi-Yu Zhong, Meng-Sha Zou, Qing-Nan Tang, Wen-Hui Chen, Shan-Shan Guo, Li-Ting Liu, Yang Li, Ling Guo, Hao-Yuan Mo, Rui Sun, Dong-Hua Luo, Chong Zhao, Ka-Jia Cao, Chao-Nan Qian, Xiang Guo, Mu-Sheng Zeng, Hai-Qiang Mai
Purpose: Little is known about combination of the circulating Epstein-Barr viral (EBV) DNA and tumor volume in prognosis of stage II nasopharyngeal carcinoma (NPC) patients in the intensity modulated radiotherapy (IMRT) era. We conducted this cohort study to evaluate the prognostic values of combining these two factors. Materials and Methods: By Kaplan-Meier, we compare the differences of survival curves between 385 patients with different EBV DNA or tumor volume levels, or with the combination of two biomarkers mentioned above...
September 13, 2017: Cancer Research and Treatment: Official Journal of Korean Cancer Association
https://www.readbyqxmd.com/read/28900497/pretreatment-nomograms-for-local-and-regional-recurrence-after-radical-radiation-therapy-for-primary-nasopharyngeal-carcinoma
#14
Fo-Ping Chen, Li Lin, Zhen-Yu Qi, Guan-Qun Zhou, Rui Guo, Jiang Hu, Ai-Hua Lin, Jun Ma, Ying Sun
Background: The aim of this study was to build nomograms to predict local recurrence (LR) and regional recurrence (RR) in patients with nasopharyngeal carcinoma (NPC) underwent intensity-modulated radiation therapy (IMRT). Patients and Methods : A total of 1811 patients with non-metastatic NPC treated with IMRT (with or without chemotherapy) between October 2009 and February 2012 at our center were involved for building the nomograms. Nomograms for LR-free rate and RR-free rate at 3- and 5- year were generated as visualizations of Cox proportional hazards regression models, and validated using bootstrap resampling, estimating discrimination and calibration...
2017: Journal of Cancer
https://www.readbyqxmd.com/read/28874193/extranodal-nasal-type-natural-killer-t-cell-lymphoma-with-penile-involvement-a-case-report-and-review-of-the-literature
#15
Xiaotian Wang, Zimu Gong, Shawn Xiang Li, Wei Yan, Yongsheng Song
BACKGROUND: Extranodal natural killer/T-cell lymphoma (ENKTL) usually presents as a localized disease in the nasal cavity; extension to the male genitourinary system is very rare and has been characterized only recently. Most cases present with predominantly extranodal involvement, advanced stage disease, highly aggressive course, and strong association with Epstein-Barr virus (EBV). While metastasis is common in ENKTLs, the penis is rarely involved in both nasal and non-nasal ENKTLs and only one report was published to date...
September 6, 2017: BMC Urology
https://www.readbyqxmd.com/read/28838455/an-unusual-posttransplant-t-cell-lymphoma-after-liver-transplantation-a-case-report
#16
I E Obiorah, M Ozdemirli
Posttransplantation lymphoproliferative disorders (PTLDs) encompass a spectrum of heterogeneous entities ranging from benign lymphocytic proliferations to high-grade malignant lymphomas. The majority of PTLDs are associated with reactivation of Epstein-Barr virus (EBV), which induces B-cell proliferation and occurs in the setting of severe immune suppression after solid organ or bone marrow transplantation. T-cell/natural killer cell PTLDs are relatively rare, constituting ∼15% of all cases. T-cell PTLDs are usually aggressive, and outcomes are poor...
September 2017: Transplantation Proceedings
https://www.readbyqxmd.com/read/28814970/prevalence-and-characteristics-of-epstein-barr-virus-associated-gastric-carcinomas-in-portugal
#17
Célia Nogueira, Marta Mota, Rui Gradiz, Maria Augusta Cipriano, Francisco Caramelo, Hugo Cruz, Ana Alarcão, Francisco Castro E Sousa, Fernando Oliveira, Fernando Martinho, João Moura Pereira, Paulo Figueiredo, Maximino Leitão
BACKGROUND: Gastric cancer (GC) is one of the most common malignant tumors of the digestive tract and is the third leading cause of cancer death worldwide. Epstein-Barr virus (EBV) has been associated with approximately 10% of the total cases of gastric carcinomas. No previous study has analyzed the prevalence of EBV infection in gastric cancer of the Portuguese population. METHODS: In the present study, we have analyzed 82 gastric carcinoma cases and 33 healthy individuals (control group) from Coimbra region for the presence of EBV by polymerase chain reaction (PCR) and by in situ hybridization (ISH) for EBV-encoded small RNAs (EBERs)...
2017: Infectious Agents and Cancer
https://www.readbyqxmd.com/read/28800008/epstein-barr-virus-infection-can-be-a-secondary-event-in-b-cell-lymphomas-a-review-of-338-cases-and-a-novel-finding-of-zonal-eber-tumor-cells-showing-features-of-progression-from-underlying-ebv-negative-lymphoma
#18
Ira J Miller
Cases of B-cell lymphoma over an 8-year interval with diagnosis of EBER positivity were retrieved from archives and reviewed for classification and pattern of Epstein Barr Virus (EBV) expression. Of 46 cases that were EBV early RNA (EBER)+ by in situ hybridization staining, 7 had nonuniform staining among the neoplastic cells. Four of those cases showed a uniform admixture of EBER+ and EBER- tumor cells, compatible with the prevailing theory of episomal EBV loss with cell replication. Three cases of lymphomas showed a partial and zonal pattern and other features suggest that EBV infection occurred after the lymphoma was already established...
August 9, 2017: Applied Immunohistochemistry & Molecular Morphology: AIMM
https://www.readbyqxmd.com/read/28796808/pd-l1-and-gastric-cancer-prognosis-a-systematic-review-and-meta-analysis
#19
REVIEW
Lihu Gu, Manman Chen, Dongyu Guo, Hepan Zhu, Wenchao Zhang, Junhai Pan, Xin Zhong, Xinlong Li, Haoran Qian, Xianfa Wang
The expression of Programmed cell Death Ligand 1 (PD-L1) is observed in many malignant tumors and is associated with poor prognosis including Gastric Cancer (GC). The relationship between PD-L1 expression and prognosis, however, is controversial in GC. This paper purports to use a meta-analysis to investigate the relationship between PD-L1 expression and prognosis in GC. For this study, the following databases were searched for articles published from June 2003 until February 2017: PubMed, EBSCO, Web of Science and Cochrane Library...
2017: PloS One
https://www.readbyqxmd.com/read/28754096/successful-treatment-with-anti-programmed-death-1-antibody-in-a-relapsed-natural-killer-t-cell-lymphoma-patient-with-multi-line-resistance-a-case-report
#20
Jianping Lai, Peng Xu, Xiaoliu Jiang, Shan Zhou, Anwen Liu
BACKGROUND: Extranodal natural killer/T-cell lymphoma (NKTCL), nasal type, is an aggressive malignancy with poor prognosis. Currently, there is no recommended standard therapy for relapsed NKTCL. CASE PRESENTATION: A 37-year-old woman with lymphadenopathy was diagnosed with NKTCL by biopsy of an enlarged lymph node on the right side of her neck. Enhanced computed tomography revealed no metastasis. For this patient, we performed continuous chemotherapy followed by radiotherapy; however, nodule biopsy showed metastases in her lower limbs 3 months after radiotherapy, which confirmed disease progression...
July 28, 2017: BMC Cancer
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