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EBV Lymph Node

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https://www.readbyqxmd.com/read/29928206/integrated-diagnostic-model-that-incorporates-epstein-barr-virus-dna-imaging-and-nasal-endoscopy-to-stratify-primary-tumor-and-lymph-nodes-in-a-patient-with-n1-nasopharyngeal-carcinoma-multidisciplinary-management
#1
Paolo Gamba, Luigina Rota, C Abeni, Alessandra Huscher, Gabriele Saldi, Alberto Soregaroli, Elena Padolecchia, Fausto Zorzi, Mario Bignardi, Alberto Zaniboni
Nasopharyngeal carcinoma (NPC) is an epithelial malignancy, with a high metastatic potential. Epstein-Barr virus (EBV) infection plays a fundamental role, even if it is not well understood. The diagnosis of the disease in its early stage is infrequent. Imaging studies, positron emission tomography scans in addition to clinical examination, endoscopic examination, and biopsy provide information on the extent of the disease. The application of neoadjuvant chemotherapy followed by concomitant chemoradiation can improve the control of NPC...
May 2018: Case Reports in Oncology
https://www.readbyqxmd.com/read/29888018/comparison-of-diagnostic-cytomorphology-of-natural-killer-t-cell-lymphoma-nasal-type-in-conventional-smears-liquid-based-preparations-and-histopathology
#2
Chih-Yi Liu, Hui-Chih Tsai
Natural killer (NK)/T-cell lymphoma is formally referred to as extranodal NK/T-cell lymphoma, nasal type (ENKTCL), in the 2008 and 2016 World Health Organization (WHO) classifications. NK/T-cell lymphoma, nasal type, is a rare but clinically important lymphoid neoplasm. It is the predominant type of extranodal lymphoma associated with the Epstein-Barr virus (EBV). NK/T-cell lymphoma is marked by a wide cytomorphological spectrum. The cytological findings may be so subtle that NK/T-cell lymphoma could possibly be easily overlooked...
2018: Case Reports in Pathology
https://www.readbyqxmd.com/read/29885658/ebv-associated-lymphoepithelioma-like-thyroid-carcinoma-with-favorable-outcome-case-report-with-cytopathologic-and-histopathologic-study
#3
Chih-Yi Liu, Shih-Hung Huang
BACKGROUND: Lymphoepithelioma-like carcinoma (LELC) is a rare entity among thyroid tumors. Based on the limited number of case reports that exist, the association of Epstein-Barr virus (EBV) with primary thyroid LELCs seems inconsistent. CASE PRESENTATION: We present a confusing cytological case of lymphoepithelioma-like thyroid carcinoma with expression of EBV. The patient presented with a central neck mass and bilateral lymphadenopathy. Fine-needle aspiration cytology revealed three-dimensional and syncytial fragments of epithelioid cells accompanied by small lymphocytes...
June 9, 2018: Diagnostic Pathology
https://www.readbyqxmd.com/read/29859006/clinicopathological-features-of-22c3-pd-l1-expression-with-mismatch-repair-epstein-barr-virus-status-and-cancer-genome-alterations-in-metastatic-gastric-cancer
#4
Akihito Kawazoe, Kohei Shitara, Yasutoshi Kuboki, Hideaki Bando, Takashi Kojima, Takayuki Yoshino, Atsushi Ohtsu, Atsushi Ochiai, Yosuke Togashi, Hiroyoshi Nishikawa, Toshihiko Doi, Takeshi Kuwata
BACKGROUND: Recently, the U.S. Food and Drug Administration approved pembrolizumab for patients (pts) with PD-L1-positive metastatic gastric cancer (MGC) based on 22C3 immunohistochemistry (IHC) assay. However, little is known about detailed clinicopathological features of 22C3 PD-L1 expression in MGC. PATIENTS AND METHODS: Pts with histologically confirmed MGC were eligible for this prospective observational study. PD-L1 expression (22C3) on tumor cell (TC) or immune cell (IC) and mismatch repair (MMR) were analyzed by IHC...
June 1, 2018: Gastric Cancer
https://www.readbyqxmd.com/read/29848986/the-transition-between-telomerase-and-alt-mechanisms-in-hodgkin-lymphoma-and-its-predictive-value-in-clinical-outcomes
#5
Radhia M'kacher, Corina Cuceu, Mustafa Al Jawhari, Luc Morat, Monika Frenzel, Grace Shim, Aude Lenain, William M Hempel, Steffen Junker, Theodore Girinsky, Bruno Colicchio, Alain Dieterlen, Leonhard Heidingsfelder, Claire Borie, Noufissa Oudrhiri, Annelise Bennaceur-Griscelli, Olivier Moralès, Sarah Renaud, Zoé Van de Wyngaert, Eric Jeandidier, Nadira Delhem, Patrice Carde
Background : We analyzed telomere maintenance mechanisms (TMMs) in lymph node samples from HL patients treated with standard therapy. The TMMs correlated with clinical outcomes of patients. Materials and Methods : Lymph node biopsies obtained from 38 HL patients and 24 patients with lymphadenitis were included in this study. Seven HL cell lines were used as in vitro models. Telomerase activity (TA) was assessed by TRAP assay and verified through hTERT immunofluorescence expression; alternative telomere lengthening (ALT) was also assessed, along with EBV status...
May 30, 2018: Cancers
https://www.readbyqxmd.com/read/29843478/clinical-importance-of-epstein%C3%A2-barr-virus-associated-gastric-cancer
#6
REVIEW
Jun Nishikawa, Hisashi Iizasa, Hironori Yoshiyama, Kanami Shimokuri, Yuki Kobayashi, Sho Sasaki, Munetaka Nakamura, Hideo Yanai, Kohei Sakai, Yutaka Suehiro, Takahiro Yamasaki, Isao Sakaida
Epstein⁻Barr virus-associated gastric carcinoma (EBVaGC) is the most common malignancy caused by EBV infection. EBVaGC has definite histological characteristics similar to gastric carcinoma with lymphoid stroma. Clinically, EBVaGC has a significantly low frequency of lymph node metastasis compared with EBV-negative gastric cancer, resulting in a better prognosis. The Cancer Genome Atlas of gastric adenocarcinomas proposed a molecular classification divided into four molecular subtypes: (1) EBVaGC; (2) microsatellite instability; (3) chromosomal instability; and (4) genomically stable tumors...
May 29, 2018: Cancers
https://www.readbyqxmd.com/read/29808625/pathologic-study-of-tumour-extension-for-clinically-localized-unilateral-nasopharyngeal-carcinoma-should-the-contralateral-side-be-included-in-the-clinical-target-volume
#7
An-Chuan Li, Ying-Ying Zhang, Chi Zhang, De-Sheng Wang, Ben-Hua Xu
INTRODUCTION: The clinical target volume (CTV) delineation is crucial for tumour control and normal tissue protection. This study investigated the contralateral extension of nasopharyngeal carcinoma (NPC) in patients with a clinically diagnosed unilateral tumour to pursue the possibility of CTV reduction. METHODS: Twenty NPC patients with localized tumours confined to only one side of the nasopharynx as shown by magnetic resonance imaging and fibreoptic endoscopy were selected for biopsy...
May 28, 2018: Journal of Medical Imaging and Radiation Oncology
https://www.readbyqxmd.com/read/29796326/castleman-s-disease-and-posttransplant-lymphoproliferative-disorder-after-liver-transplant-3-year-follow-up
#8
Lokesh K Jha, Laura L Ulmer, Marco A Olivera-Martinez, Timothy M McCashland, Kai Fu, Fedja A Rochling
A 59-year-old male with a history of hepatitis C cirrhosis and history of hepatitis B exposure presented 8 months after orthotopic liver transplant (LT) with fever, fatigue, myalgia, night sweats, nonproductive cough, and shortness of breath. Bone marrow biopsy for pancytopenia was positive for Epstein-Barr virus (EBV) DNA. Lymph node biopsy for lymphadenopathy on imaging showed human herpes virus 8 (HHV8) associated Castleman's disease. Treatment included valganciclovir, rituximab, and prednisone taper with eventual discontinuation...
2018: Case Reports in Hepatology
https://www.readbyqxmd.com/read/29755021/a-single-center-experience-of-post-transplant-lymphoproliferative-disorder-ptld-cases-after-pediatric-liver-transplantation-incidence-outcomes-and-association-with-food-allergy
#9
Zeren Barış, Figen Özçay, Özlem Yılmaz Özbek, Nihan Haberal, Faik Sarıalioğlu, Mehmet Haberal
BACKGROUND/AIMS: We evaluated our 16-year single-center experience of pediatric post-transplant lymphoproliferative disorder (PTLD) cases who underwent liver transplantation between 2001 and 2017. MATERIALS AND METHODS: Of the 236 pediatric patients who underwent liver transplantation between 2001 and 2017, the clinical and laboratory data of eight patients diagnosed with PTLD were reviewed. The pre-transplant Epstein-Barr virus (EBV) status of 172 patients was also recorded...
May 2018: Turkish Journal of Gastroenterology: the Official Journal of Turkish Society of Gastroenterology
https://www.readbyqxmd.com/read/29729036/epstein-barr-virus-positivity-among-surgically-resected-intramucosal-gastric-cance
#10
Katsuyuki Murai, Naomi Kakushima, Takashi Sugino, Masao Yoshida, Noboru Kawata, Masaki Tanaka, Kohei Takizawa, Koji Muramatu, Kimihide Kusafuka, Etsuro Bando, Hiroyuki Ono
Epstein-Barr virus-associated gastric cancer (EBV-GC) accounts for approximately 8% of gastric cancers. However, little is known regarding intramucosal EBV-GC. The present study aimed to evaluate endoscopic and clinicopathological characteristics of intramucosal EBV-GC. Pathological data of 172 patients with 173 intramucosal gastric cancers who received gastrectomy with lymph node dissection were obtained for review. EBV-encoded small RNA in situ hybridization (EBER-ISH) was performed using tissue microarray block...
May 5, 2018: Digestive Endoscopy: Official Journal of the Japan Gastroenterological Endoscopy Society
https://www.readbyqxmd.com/read/29676371/methotrexate-associated-epstein-barr-virus-mucocutaneous-ulcer-a-case-report-and-review-of-literature
#11
Priyanka Yogendra Ravi, Elanthenral Sigamani, Yasir Jeelani, Marie Therese Manipadam
Epstein-Barr virus-positive mucocutaneous ulcer (EBVMCU) comprises part of the spectrum of B-cell lymphoproliferative disorders, reported in settings of immunosenescence and iatrogenic immunosuppression, affecting the oropharyngeal mucosa, skin, and gastrointestinal tract. We report a case of a 59-year-old female, known case of rheumatoid arthritis on methotrexate (MTX) for 15 years, who presented with an ulcer in the inner aspect of her cheek region for 2 years. Clinical examination revealed an infiltrative lesion involving the lower gingivobuccal sulcus of size 2 cm × 3 cm extending to the alveolus with level I lymph nodes, suspicious for carcinoma buccal mucosa...
April 2018: Indian Journal of Pathology & Microbiology
https://www.readbyqxmd.com/read/29676363/lymphomatoid-granulomatosis-a-case-series-from-south-india
#12
Elanthenral Sigamani, Jagan Chandramohan, Sheila Nair, Geeta Chacko, Meera Thomas, Leni Grace Mathew, Susanne Pulimood, Marie Therese Manipadam
Context: Lymphomatoid granulomatosis (LYG) is a rare B-lymphoproliferative disorder characterised by an angiocentric and angiodestructive pattern along with Epstein - Barr virus (EBV) association. It is one of the diagnostic challenges in lymphoma pathology. Deregulation of EBV immune surveillance is one of the narrated hypotheses in the literature. Extrapulmonary manifestations are rare with LYG. Morphological grading is done based on the number of EBV-positive B cells, which is useful to strategize treatment protocol...
April 2018: Indian Journal of Pathology & Microbiology
https://www.readbyqxmd.com/read/29615001/epstein-barr-virus-positive-peripheral-t-cell-lymphoma-with-novel-variants-in-stat5b-of-a-pediatric-patient-a-case-report
#13
Zihang Chen, Limin Gao, Mi Wang, Yuan Tang, Sha Zhao, Weiping Liu
BACKGROUND: Epstein-Barr virus positive peripheral T cell lymphoma (EBV + PTCL) is a rare type of lymphoproliferative disorder which is always present in late adulthood. However, pediatric EBV + PTCL is extremely rare and always present with lymphadenopathy. Additionally, gene detection was not performed in all of these pediatric patients. CASE PRESENTATION: We report an EBV + PTCL in a 9-year-old child with initial symptom of subcutaneous masses without lymph node involvement...
April 3, 2018: BMC Cancer
https://www.readbyqxmd.com/read/29541465/epstein-barr-virus-associated-early-gastric-carcinoma-with-lymphoid-stroma-accompanied-with-lymph-node-metastasis
#14
Tsutomu Namikawa, Kazune Fujisawa, Eri Munekage, Masaya Munekage, Yusuke Oki, Hiromichi Maeda, Hiroyuki Kitagawa, Hiroshi Ueta, Michiya Kobayashi, Kazuhiro Hanazaki
The present case report presents a rare case of Epstein-Barr virus (EBV)-associated early gastric carcinoma with lymphoid stroma, accompanied by lymph node metastasis. A 61-year-old woman was referred to our hospital following observation of a gastric mass lesion that was initially diagnosed at a medical check-up. Esophagogastroduodenoscopy revealed a slightly elevated lesion with a central irregular depression in the middle third of the stomach. Endoscopic ultrasonography revealed a well-circumscribed hypoechoic mass located predominantly within the submucosa and the mucosa...
April 2018: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/29541176/correlation-of-nasopharyngeal-carcinoma-with-rare-earth-elements-and-the-epstein-barr-virus
#15
Xiangmin Zhang, Xiangfu Zeng, Lianbin Liu, Xiaolin Lan, Jing Huang, Hongxue Zeng, Rong Li, Keqing Luo, Wei Wu, Maohua Zhou, Shaojin Li
The concentration and distribution of rare earth elements (REE) in nasopharyngeal carcinoma (NPC) were measured to investigate connections with tumor size, lymph node metastasis, clinical stages, and Epstein-Barr virus (EBV) infection. There were 30 patients with NPC who met the criteria for inclusion in the present study. The EBV copy number, as well as the concentration and distribution of REE, was analyzed. EBV was detected using reverse transcription-polymerase chain reaction, with the concentrations of REE in NPC tissues measured using inductively coupled plasma-tandem mass spectrometry...
April 2018: Oncology Letters
https://www.readbyqxmd.com/read/29401153/68ga-dotatate-pet-ct-reveals-epstein-barr-virus-associated-nasopharyngeal-carcinoma-in-a-case-of-suspected-sphenoid-wing-meningioma
#16
Marcus Unterrainer, Cornelius Maihoefer, Clemens C Cyran, Peter Bartenstein, Maximilian Niyazi, Nathalie Lisa Albert
In this case of suspected sphenoid wing meningioma, Ga-DOTATATE PET/CT showed a somatostatin receptor (SSR)-expressing tumor with extension to the nasopharynx and SSR-expressing cervical lymph nodes. Subsequent biopsy from the nasopharynx revealed an Epstein-Barr virus (EBV)-associated, undifferentiated World Health Organization type 3 nasopharyngeal carcinoma (NPC), a potential clinical pitfall due to the reported high SSR expression of this tumor subtype. In consideration of the high target-to-background contrast, SSR ligands might be superior to F-FDG for EBV-associated NPC PET imaging, particularly at the skull base...
April 2018: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/29382466/characterization-of-sentinel-node-derived-antibodies-from-breast-cancer-patients
#17
Girja S Shukla, Stephanie C Pero, Yu-Jing Sun, Chelsea L Carman, Seth Harlow, David N Krag
Autoantibodies to breast and other cancers are commonly present in cancer patients. A method to rapidly produce these anti-cancer autoantibodies in the lab would be valuable for understanding immune events and to generate candidate reagents for therapy and diagnostics. The purpose of this report is to evaluate sentinel nodes (SNs) of breast cancer patients as a source of anti-cancer antibodies. Radiotracer lymphatic mapping in 29 patients with breast cancer confirmed the identity of the SNs which provided source cells for this study...
April 2018: Journal of Immunological Methods
https://www.readbyqxmd.com/read/29380871/extranodal-natural-killer-t-cell-lymphoma-nasal-type-in-senegal
#18
Moussa Diallo, Assane Diop, Boubacar A Diatta, Maodo Ndiaye, Nicolas Ortonne, Mame T Dieng
INTRODUCTION: The distribution of extranodal NK/T-cell lymphoma (ENKTCL) is highly inhomogeneous throughout the world. In Sub-Saharan Africa, despite the precocity of Epstein-Barr virus (EBV) infection and its endemicity, ENKTCL remains exceptionally reported. The purpose of this study was to report the epidemiological, clinical, paraclinical, and evolutionary characteristics of ENKTCL at the Aristide LeDantec University Hospital in Dakar, Senegal. METHODOLOGY: A 5-year retrospective review of all patients with histopathological, immunohistochemical, and in situ hybridization proven cutaneous lymphomas RESULTS: We collected seven cases corresponding to a frequency of 1...
April 2018: International Journal of Dermatology
https://www.readbyqxmd.com/read/29380181/classical-hodgkin-lymphoma-type-post-transplant-lymphoproliferative-disorder-in-a-kidney-transplant-recipient-a-diagnostic-pitfall
#19
Taro Mohri, Yoshihiro Ikura, Asako Hirakoso, Masashi Okamoto, Masakatsu Hishizawa, Akifumi Takaori-Kondo, Seiichi Kato, Shigeo Nakamura, Kai Yoshimura, Hidetoshi Okabe, Yasuhiro Iwai
We report a case of classical Hodgkin lymphoma type post-transplant lymphoproliferative disorder (HL-PTLD) after kidney transplantation to highlight the difficulty of distinguishing this disorder from Hodgkin lymphoma-like PTLD (HL-like PTLD). Through this case report and literature review, we seek to clarify definitive pathologic features to differentiate these two conditions. A 38-year-old male kidney transplant recipient who had been receiving immunosuppressants was admitted to our hospital with unidentified high fever...
January 29, 2018: International Journal of Hematology
https://www.readbyqxmd.com/read/29284539/prognostic-values-of-the-integrated-model-incorporating-the-volume-of-metastatic-regional-cervical-lymph-node-and-pretreatment-serum-epstein-barr-virus-dna-copy-number-in-predicting-distant-metastasis-in-patients-with-n1-nasopharyngeal-carcinoma
#20
Ji-Jin Yao, Guan-Qun Zhou, Ya-Qin Wang, Si-Yang Wang, Wang-Jian Zhang, Ya-Nan Jin, Fan Zhang, Li Li, Li-Zhi Liu, Zhi-Bin Cheng, Jun Ma, Zhen-Yu Qi, Ying Sun
BACKGROUND: According to the 7th edition of the American Joint Committee on Cancer (AJCC) staging system, over 50% of patients with nasopharyngeal carcinoma (NPC) have N1 disease at initial diagnosis. However, patients with N1 NPC are relatively under-researched, and the metastasis risk of this group is not well-stratified. This study aimed to evaluate the prognostic values of gross tumor volume of metastatic regional lymph node (GTVnd) and pretreatment serum copy number of Epstein-Barr virus (EBV) DNA in predicting distant metastasis of patients with N1 NPC, and to develop an integrated prognostic model that incorporates GTVnd and EBV DNA copy number for this group of patients...
December 29, 2017: Chinese Journal of Cancer
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