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https://www.readbyqxmd.com/read/29782446/minimally-invasive-proximal-interphalangeal-joint-arthrodesis-using-headless-screw-surgical-technique
#1
Elizabeth A Newman, Maria C Orbay, Fiesky A Nunez, Fiesky Nunez
Proximal interphalangeal (PIP) joint arthritis causes debilitating hand pain and instability leading to significant functional impairment. Arthrodesis remains the gold standard for treatment of PIP arthritis. We present a minimally invasive PIP arthrodesis that provides rigid fixation with a headless compression screw. Seven patients who presented to the senior author with PIP joint arthritis underwent PIP arthrodesis by minimally invasive technique. A 1 cm transverse incision is made over the PIP joint, incising skin, central band, and articular capsule...
June 2018: Techniques in Hand & Upper Extremity Surgery
https://www.readbyqxmd.com/read/29782303/clindamycin-induced-maculopapular-exanthema-with-preferential-involvement-of-striae-distensae-a-koebner-phenomenon
#2
Benigno Monteagudo, Miguel Cabanillas, Pilar Iriarte, Aquilina Ramírez-Santos, Elvira León-Muinos, Daniel González-Vilas, Óscar Suárez-Amor
Clindamycin is a lincomycin-derived antibiotic useful for the treatment of anaerobic and Gram-positive aerobic bacterial infections. Cutaneous adverse reactions are usually maculopapular exanthemas, although hypersensitivity syndrome, acute generalized exanthematous pustulosis, and Stevens-Johnson syndrome have also been reported (1). We report the case of a patient with a maculopapular rash triggered by clindamycin who developed cutaneous lesions on striae distensae (SD). A 47-year-old woman was referred to our clinic for pruritic cutaneous lesions which had started 6 days earlier...
April 2018: Acta Dermatovenerologica Croatica: ADC
https://www.readbyqxmd.com/read/29782007/intraportal-transplantation-of-pancreatic-islets-in-mouse-model
#3
Rahul Khatri, Birte Hussmann, Divya Rawat, Ali Osman Gürol, Thomas Linn
Pancreatic islet transplantation to reduce hyperglycemia is highly successful in rodents with chemically-induced diabetes. The most common transplantation site in experimental islet transplantation is the kidney capsule. However, as less is known about the interaction of pancreatic islets with blood constituents, it also makes sense to utilize the portal vein approach in experimental islet transplantation. This protocol demonstrates an intraportal islet transplantation technique in NMRI nude mice. Streptozotocin (180 mg/kg) is injected intraperitoneally to induce hyperglycemia in recipient mice...
May 5, 2018: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/29781422/spirocerca-vulpis-sp-nov-spiruridae-spirocercidae-description-of-a-new-nematode-species-of-the-red-fox-vulpes-vulpes-carnivora-canidae
#4
Alicia Rojas, Gloria Sanchis-Monsonís, Amer Alić, Adnan Hodžić, Domenico Otranto, Daniel Yasur-Landau, Carlos Martínez-Carrasco, Gad Baneth
Previous studies have reported nematodes of the Spirocercidae family in the stomach nodules of red foxes (Vulpes vulpes) described as Spirocerca sp. or Spirocerca lupi (Rudolphi, 1819). We characterized spirurid worms collected from red foxes and compared them to S. lupi from domestic dogs by morphometric and phylogenetic analyses. Nematodes from red foxes differed from S. lupi by the presence of six triangular teeth-like buccal capsule structures, which are absent in the latter. Additionally, in female worms from red foxes, the distance of the vulva opening to the anterior end and the ratio of the glandular-to-muscular oesophagus lengths were larger than those of S...
May 21, 2018: Parasitology
https://www.readbyqxmd.com/read/29780949/two-cases-of-very-late-onset-capsular-bag-distension-syndrome
#5
Justin C Galvin, Paula Berdoukas, Adrian T Fung
Purpose: We present two cases of late-onset capsular bag distension syndrome (CBDS). Observations: Two female patients were referred with decreased visual acuity and blurred vision. They had both undergone uncomplicated phacoemulsification and intraocular lens implantation into the capsular bag, seven and 13 years prior.Slit-lamp biomicroscopy and anterior segment optical coherence tomography demonstrated milky fluid between the intraocular lens and posterior capsules, consistent with late-onset capsular bag distension syndrome...
June 2018: American Journal of Ophthalmology Case Reports
https://www.readbyqxmd.com/read/29780852/parkinson-s-patients-with-dyskinesia-switched-from-immediate-release-amantadine-to-open-label-ads-5102
#6
Stuart H Isaacson, Stanley Fahn, Rajesh Pahwa, Caroline M Tanner, Alberto J Espay, Claudia Trenkwalder, Charles H Adler, Rajiv Patni, Reed Johnson
Background: ADS-5102 (amantadine) extended release capsules (GOCOVRI™) are a treatment for dyskinesia in patients with Parkinson's disease (PD). ADS-5102 reduced dyskinesia and OFF time in phase 3 controlled trials of up to six months. Amantadine immediate release (IR) is used for dyskinesia, but suboptimal durability and tolerability limit its clinical utility. Methods: In an ongoing, open-label, phase 3 study in the US and Western Europe (NCT02202551), patients with PD received 274 mg of ADS-5102 (equivalent to 340 mg amantadine HCl) once daily at bedtime for up to two years...
March 2018: Movement Disorders Clinical Practice
https://www.readbyqxmd.com/read/29780750/the-luxs-ai-2-quorum-sensing-system-of-streptococcus-pneumoniae-is-required-to-cause-disease-and-to-regulate-virulence-and-metabolism-related-genes-in-a-rat-model-of-middle-ear-infection
#7
Mukesh K Yadav, Jorge E Vidal, Yoon Y Go, Shin H Kim, Sung-Won Chae, Jae-Jun Song
Objective: Streptococcus pneumoniae colonizes the nasopharynx of children, and from nasopharynx it could migrate to the middle ear and causes acute otitis media (AOM). During colonization and AOM, the pneumococcus forms biofilms. In vitro biofilm formation requires a functional LuxS/AI-2 quorum-sensing system. We investigated the role of LuxS/AI-2 signaling in pneumococcal middle ear infection, and identified the genes that are regulated by LuxS/AI-2 during pneumococcal biofilm formation. Methods: Streptococcus pneumoniae D39 wild-type and an isogenic D39Δ luxS strain were utilized to evaluate in vitro biofilm formation, and in vivo colonization and epithelial damage using a microtiter plate assay and a rat model of pneumococcal middle ear infection, respectively...
2018: Frontiers in Cellular and Infection Microbiology
https://www.readbyqxmd.com/read/29780539/how-does-chiral-self-sorting-take-place-in-the-formation-of-homochiral-pd-6-l-8-capsules-consisting-of-cyclotriveratrylene-based-chiral-tritopic-ligands
#8
Shumpei Kai, Tatsuo Kojima, Flora L Thorp-Greenwood, Michaele J Hardie, Shuichi Hiraoka
The chiral self-sorting process during the self-assembly of homochiral Pd6 L8 capsules from cyclotriveratrylene (CTV)-based chiral tritopic ligands (L) and (Py*: 3-chloropyridine) was investigated by an NMR-based approach (QASAP: quantitative analysis of the self-assembly process). From the beginning to the formation of the immature capsules ( IC s), enantiomeric ligands are distributed in the intermediates in a non-self-sorting manner, which leads to the isomers of heterochiral IC s over 99% yield. The mismatch of the chirality in the heterochiral IC s prevents intramolecular ligand exchanges in IC s to form the heterochiral capsules...
May 7, 2018: Chemical Science
https://www.readbyqxmd.com/read/29780132/a-japanese-case-of-cadasil-with-a-rare-mutation-in-exon-24-of-the-notch3-gene
#9
Yuka Ebihara, Hitoshi Mochizuki, Nobuyuki Ishii, Ikuko Mizuta, Kazutaka Shiomi, Toshiki Mizuno, Masamitsu Nakazato
A 50-year-old man with a family history of stroke and depression slowly developed brain lesions. Magnetic resonance imaging revealed hyperintense lesions in the diffuse white matter, external capsules, and temporal poles on T2-weighted imaging. A heterozygous mutation c.3879C>G in exon 24 of the NOTCH3 gene (p.Cys1293Trp) was detected, confirming a diagnosis of cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL). Exon 24 mutations are rather rare and this represents the first Japanese case of CADASIL...
May 18, 2018: Internal Medicine
https://www.readbyqxmd.com/read/29779845/effects-of-estradiol-on-lactoprivic-signaling-of-the-hindbrain-upon-the-contraregulatory-hormonal-response-and-metabolic-neuropeptide-synthesis-in-hypoglycemic-female-rats
#10
Santosh K Mandal, Prem K Shrestha, Fahaad S H Alenazi, Manita Shakya, Hussain N Alhamami, Karen P Briski
BACKGROUND: Caudal dorsomedial hindbrain detection of hypoglycemia-associated lactoprivation regulates glucose counter-regulation in male rats. In females, estradiol (E) determines hypothalamic neuroanatomical and molecular foci of hindbrain energy sensor activation. This study investigated the hypothesis that E signal strength governs metabolic neuropeptide and counter-regulatory hormone responses to hindbrain lactoprivic stimuli in hypoglycemic female rats. METHODS: Ovariectomized animals were implanted with E-filled silastic capsules [30 (E-30) or 300 μg (E-300)/mL] to replicate plasma concentrations at estrous cycle nadir versus peak levels...
May 17, 2018: Neuropeptides
https://www.readbyqxmd.com/read/29779816/omega-3-supplementation-effects-on-body-weight-and-depression-among-dieter-women-with-co-morbidity-of-depression-and-obesity-compared-with-the-placebo-a-randomized-clinical-trial
#11
Seyed Ali Keshavarz, Seyed-Ali Mostafavi, Shahin Akhondzadeh, Mohammad Reza Mohammadi, Saeed Hosseini, Mohammad Reza Eshraghian, Maryam Chamari
PURPOSE: We aimed to evaluate the effects of the omega-3 supplementation on body weight and depression among women with co-morbidity of depression and obesity seeking weight reduction compared with the placebo. METHODS: Sixty five patients with co-morbidity of depression and overweight/obesity (BMI ≥ 25) signed the informed consent form and enrolled into this 12-week double-blind, placebo-controlled randomized clinical Trial. Subsequently, participants randomly assigned into one of the two groups receiving daily 6 capsules of omega-3 (each capsule containing 180 mg EPA, and 120 mg DHA) or 6 capsules of placebo (two with each meal)...
June 2018: Clinical Nutrition ESPEN
https://www.readbyqxmd.com/read/29779696/preliminary-study-of-magnetically-controlled-capsule-gastroscopy-for-diagnosing-superficial-gastric-neoplasia
#12
Yang-Yang Qian, Shu-Guang Zhu, Xi Hou, Wei Zhou, Wei An, Xiao-Ju Su, Mark Edward McAlindon, Zhao-Shen Li, Zhuan Liao
BACKGROUND: Magnetically controlled capsule gastroscopy (MCCG) is a newly developed non-invasive method designed for gastric examination. Although favorable diagnostic accuracy has been reported, there is little if any data about its ability to diagnose gastric cancer. AIMS: To compare the detectability of superficial gastric neoplasia by MCCG and gastroscopy. METHODS: This study was a self-controlled comparison study. Ten subjects diagnosed with superficial gastric neoplasia and scheduled to undergo endoscopic submucosal dissection (ESD) at a tertiary hospital were prospectively invited for an MCCG examination...
April 24, 2018: Digestive and Liver Disease
https://www.readbyqxmd.com/read/29779650/streamlined-method-for-anchoring-cataract-surgery-and-intraocular-lens-centration-on-the-patient-s-visual-axis
#13
Vance Thompson
I describe an intraoperative method for the consistent anchoring of the intraocular lens (IOL) and cataract surgery and on the patient's visual axis using coaxial microscope optics, surgeon-guided patient fixation, the precision pulse capsulotomy (PPC) device (Zepto) and utilizing the first (and fourth) Purkinje images. During surgery using a microscope with coaxial lights and optics, the patient is instructed to fixate on a given microscope light while the surgeon looks through the corresponding coaxial eyepiece...
May 17, 2018: Journal of Cataract and Refractive Surgery
https://www.readbyqxmd.com/read/29779190/therapeutic-strategies-for-modulating-the-extracellular-matrix-to-improve-pancreatic-islet-function-and-survival-after-transplantation
#14
REVIEW
Alexandra M Smink, Paul de Vos
PURPOSES OF REVIEW: Extracellular matrix (ECM) components modulate the interaction between pancreatic islet cells. During the islet isolation prior to transplantation as treatment for type 1 diabetes, the ECM is disrupted impacting functional graft survival. Recently, strategies for restoring ECM have shown to improve transplantation outcomes. This review discusses the current therapeutic strategies to modulate ECM components to improve islet engraftment. RECENT FINDINGS: Approaches applied are seeding islets in ECM of decellularized organs, supplementation of specific ECM components in polymeric scaffolds or immunoisolating capsules, and stimulating islet ECM production with specific growth factors or ECM-producing cells...
May 19, 2018: Current Diabetes Reports
https://www.readbyqxmd.com/read/29778825/nano-spray-drying-for-encapsulation-of-pharmaceuticals
#15
REVIEW
Cordin Arpagaus, Andreas Collenberg, David Rütti, Elham Assadpour, Seid Mahdi Jafari
Many pharmaceuticals such as pills, capsules, or tablets are prepared in a dried and powdered form. In this field, spray drying plays a critical role to convert liquid pharmaceutical formulations into powders. In addition, in many cases it is necessary to encapsulate bioactive drugs into wall materials to protect them against harsh process and environmental conditions, as well as to deliver the drug to the right place and at the correct time within the body. Thus, spray drying is a common process used for encapsulation of pharmaceuticals...
May 17, 2018: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/29778182/evidence-for-involvement-of-the-fas-bcax-regulon-in-capsule-synthesis-by-streptococcus-equi
#16
Sridhar Velineni, John F Timoney
The constitutively expressed hyaluronic acid capsule is an important virulence factor of Streptococcus equi, the cause of equine strangles. Study of the genomic sequence of CF22caps-, a non-encapsulated mutant of S. equi CF22 generated by gamma (Co60 ) irradiation revealed a non-sense mutation in fasC (SEQ_0302), a sensor kinase gene in FasBCAX an operon with an important regulatory role in expression of streptococcal secreted virulence and matrix binding proteins. The mutation was associated with a significant (p < ...
June 2018: Veterinary Microbiology
https://www.readbyqxmd.com/read/29778105/trailing-haptic-first-modification-of-double-needle-intrascleral-haptic-fixation-technique
#17
Dooho Brian Kim
The Yamane double-needle intrascleral haptic fixation technique for posterior chamber intraocular lens (IOL) fixation in the setting of absent or inadequate capsule support is a minimally invasive IOL fixation technique that requires scleral incisions using needles to externalize the IOL haptics. Despite being a seemingly easy and intuitive procedure, there are significant challenges when learning this technique. The most difficult step is threading the trailing haptic with the needle for fixation. If using an IOL with weak haptics, this step can result in haptic kink or breakage, which renders the haptics useless for this technique and necessitating explantation of the IOL...
April 2018: Journal of Cataract and Refractive Surgery
https://www.readbyqxmd.com/read/29777589/low-adhesive-ethylene-vinyl-alcohol-based-packaging-to-xenogeneic-islets-encapsulation-for-type-1-diabetes-treatment
#18
Kai-Chiang Yang, Goichi Yanai, Sin-Yu Yang, Priyadarshini Canning, Yoshio Satou, Masako Kawagoe, Shoichiro Sumi
Transplantation of encapsulated porcine islets is proposed to treat type 1 diabetes. However, envelopment of fibrous tissue and infiltration of immune cells impair islets function and eventually cause implant failure. It is known that hemodialysis using an ethylene vinyl alcohol (EVOH) membrane results in minor tissue responses. Therefore, we hypothesized that using a low adhesive EVOH membrane for encapsulation may prevent host cell accumulation and fibrous capsule formation. In this study, rat islets suspended in chitosan gel were encapsulated in bags made from highly porous EVOH membranes, and their in vitro insulin secretion function as well as in vivo performance were evaluated...
May 19, 2018: Biotechnology and Bioengineering
https://www.readbyqxmd.com/read/29777529/pharmacokinetics-of-ads-5102-amantadine-extended-release-capsules-administered-once-daily-at-bedtime-for-the-treatment-of-dyskinesia
#19
Robert A Hauser, Rajesh Pahwa, William A Wargin, Cindy J Souza-Prien, Natalie McClure, Reed Johnson, Jack T Nguyen, Rajiv Patni, Gregory T Went
BACKGROUND: Preclinical and clinical studies suggest amantadine immediate-release (IR) may reduce dyskinesia in Parkinson's disease (PD), although higher doses are associated with increased CNS adverse events (AEs). ADS-5102 is an extended release amantadine capsule formulation, designed for once-daily dosing at bedtime (qhs) to provide high concentrations upon waking and throughout the day, with lower concentrations in the evening. The pharmacokinetics (PK) of ADS-5102 were assessed in two phase I studies in healthy subjects, and a blinded, randomized phase II/III dose-finding study in PD patients...
May 18, 2018: Clinical Pharmacokinetics
https://www.readbyqxmd.com/read/29777518/total-pancreatic-necrosis-after-organophosphate-intoxication
#20
Rui Hou, Hongmin Zhang, Huan Chen, Yuankai Zhou, Yun Long, Dawei Liu
Cases of acute pancreatitis induced by organophosphate intoxication are encountered occasionally in clinics, but very few of them develop into severe pancreas necrosis and irreversible pancreatic function impairment. Here, we report a 47-year-old female organophosphate poisoning case after ingestion of massive insecticides; she was considered to have total necrosis and function failure of the pancreas via serum amylase test, glucose level test, and CT imaging. The patient exhibited no relief under the regular medicine treatment, which included sandostatin, antibiotics, intravenous atropine, and pralidoxime methiodide...
May 18, 2018: Frontiers of Medicine
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