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https://www.readbyqxmd.com/read/29156254/xenografted-tissue-models-for-the-study-of-human-endometrial-biology
#1
REVIEW
Satu Kuokkanen, Liyin Zhu, Jeffrey W Pollard
The human endometrium undergoes extensive morphological, biochemical and molecular changes under the influence of female sex steroid hormones. Besides the fact that estrogen stimulates endometrial cell proliferation and progesterone inhibits this proliferation and induces differentiation, there is limited knowledge about precise molecular mechanisms underlying human endometrial biology. The importance of paracrine signaling in endometrial physiology explains why in vitro culture of endometrial cells has been challenging...
November 10, 2017: Differentiation; Research in Biological Diversity
https://www.readbyqxmd.com/read/29156072/clinical-and-radiologic-outcomes-of-metatarsophalangeal-hemiarthroplasty-a-review-of-12-consecutive-cases
#2
Florian Wanivenhaus, Jacqueline Fust, Matthias Erschbamer, Andreas Schirm
This study examined function, pain, satisfaction, and radiologic outcomes among patients treated with first metatarsophalangeal hemiarthroplasty. Patients were invited to participate in an outcome study conducted with questionnaires on subjective and objective outcomes and clinical and radiographic follow-up. A total of 12 patients (12 feet; mean patient age, 58.8±12.3 years) agreed to participate. Mean follow-up was 22.3±19.8 months. Of these patients, 7 were satisfied with the postoperative result. The mean visual analog scale pain score decreased significantly from 7...
November 20, 2017: Orthopedics
https://www.readbyqxmd.com/read/29155998/limited-impact-of-adolescent-meningococcal-acwy-vaccination-on-group-w-carriage-in-university-students
#3
Neil J Oldfield, Luke R Green, Julian Parkhill, Christopher D Bayliss, David P J Turner
Background: In the UK rising disease levels due to Neisseria meningitidis serogroup W clonal complex ST-11 (MenW:cc11) strains led to introduction of conjugate MenACWY vaccination for teenagers. We investigated the impact of immunization on carriage of targeted meningococci by whole genome sequencing of isolates recovered from a cohort of vaccinated university students. Methods: Strain designation data were extracted from whole genome sequence data. Genomes from carried and invasive MenW:cc11 were compared using a gene-by-gene approach...
November 15, 2017: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/29155510/in-situ-preservation-of-parathyroid-glands-advanced-surgical-tips-for-prevention-of-permanent-hypoparathyroidism-in-thyroid-surgery
#4
Radan Dzodic, Nada Santrac
Hypoparathyroidism (HPT) is one of the most frequentand severe complications of thyroid surgery. It is caused by intraoperative damage, devascularization or accidental removal of the parathyroid glands (PTGs). The incidence of postoperative HPT is directly proportional to surgery extent and surgeon's experience. After 40 years of experience in thyroid surgery, the first author summarizes the already known surgical steps in thyroid surgery and adds some useful practical tips for in situ preservation of PTGs...
July 2017: Journal of B.U.ON.: Official Journal of the Balkan Union of Oncology
https://www.readbyqxmd.com/read/29154900/alternative-manufacturing-concepts-for-solid-oral-dosage-forms-from-drug-nanosuspensions-using-fluid-dispensing-and-forced-drying-technology
#5
Bastian Bonhoeffer, Arno Kwade, Michael Juhnke
Flexible manufacturing technologies for solid oral dosage forms with a continuous adjustability of the manufactured dose strength, are of interest for applications in personalized medicine. This study explored the feasibility of using micro-valve technology for the manufacturing of different solid oral dosage form concepts. Hard gelatin capsules filled with excipients, placebo tablets and polymer films, placed in hard gelatin capsules after drying, were considered as substrates. For each concept a basic understanding of relevant formulation parameters and their impact on dissolution behavior has been established...
November 15, 2017: Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29154863/development-of-a-selective-hplc-dad-elsd-method-for-the-qualitative-and-quantitative-assessment-of-commercially-available-eurycoma-longifolia-products-and-plant-extracts
#6
Benjamin Mutschlechner, Stefan Schwaiger, Van Anh Thi Tran, Hermann Stuppner
Aqueous extracts of the roots of Eurycoma longifolia are traditionally used to improve sexual performance, to treat infertility and other sexual dysfunctions but also to increase muscle strength. Nowadays, many different products are commercially available which are promoted as E. longifolia extracts and claim to possess beneficial aphrodisiac effects. Since such herbal aphrodisiac preparations have been recently the target of fraudulent product counterfeiting and because eurycomanone, one of the main quassinoids of E...
November 14, 2017: Fitoterapia
https://www.readbyqxmd.com/read/29154803/new-scale-down-methodology-from-commercial-to-lab-scale-to-optimize-plant-derived-soft-gel-capsule-formulations-on-a-commercial-scale
#7
Sana Oishi, Shin-Ichiro Kimura, Shuji Noguchi, Mio Kondo, Yosuke Kondo, Yoshiyuki Shimokawa, Yasunori Iwao, Shigeru Itai
A new scale-down methodology from commercial rotary die scale to laboratory scale was developed to optimize a plant-derived soft gel capsule formulation and eventually manufacture superior soft gel capsules on a commercial scale, in order to reduce the time and cost for formulation development. Animal-derived and plant-derived soft gel film sheets were prepared using an applicator on a laboratory scale and their physicochemical properties, such as tensile strength, Young's modulus, and adhesive strength, were evaluated...
November 14, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/29154054/the-effects-of-chamomile-extract-on-sleep-quality-among-elderly-people-a-clinical-trial
#8
Mohsen Adib-Hajbaghery, Seyedeh Nesa Mousavi
BACKGROUND: The prevalence of insomnia increases with age. Chamomile is among the medicinal plants which are used as tranquilizer. Yet, there is inadequate experimental and clinical evidence regarding its hypnotic effects. This study sought to evaluate the effects of chamomile extract on sleep quality among elderly people. DESIGN: A single-blind randomized controlled trial was performed. SETTING: A convenient sample of sixty elderly people who aged sixty or more and lived in Kahrizak day care nursing home, Karaj, Iran, were randomly allocated to a control and a treatment group...
December 2017: Complementary Therapies in Medicine
https://www.readbyqxmd.com/read/29153102/stability-of-compounded-trilostane-suspension-in-cod-liver-oil
#9
Jesse Crosby, Stacy Brown
Trilostane is a synthetic steroid analog used to treat canine hyperadrenocorticism. For small dogs, the dose found in commercially available dosage forms of trilostane is sometimes too high. Compounding trilostane in a liquid diluent provides an option for more precise dosing and adjustments, and can be easier to administer, versus a tablet or capsule. Trilostane suspends well in cod liver oil, which is generally palatable to dogs. The stability of a compounded trilostane suspension in cod liver oil stored at room temperature was investigated for 90 days...
October 2017: Veterinary Journal
https://www.readbyqxmd.com/read/29153063/-investigation-of-various-virulence-factors-of-klebsiella-pneumoniae-strains-isolated-from-nosocomial-infections
#10
Halit Kuş, Uğur Arslan, Hatice Türk Dağı, Duygu Fındık
Klebsiella pneumoniae is an opportunistic pathogen that commonly affects immunosuppressed patients and causes nosocomial infections. K.pneumoniae has a variety of virulence factors, especially capsule polysaccharide, hypermucoviscosity (HV), fimbriae, toxins and determinants for iron acquisition. The aim of this study was to detect the virulence factors in K.pneumoniae strains isolated from nosocomial infections in two years. Fifty three K.pneumoniae strains isolated from the samples of patients with nosocomial infections in the Medical Microbiology Laboratory of Selcuk University Faculty of Medicine Hospital between 2011 and 2013 were included in the study...
October 2017: Mikrobiyoloji Bülteni
https://www.readbyqxmd.com/read/29152990/gastroduodenal-lesions-detected-during-small-bowel-capsule-endoscopy-incidence-diagnostic-and-therapeutic-impact
#11
José Francisco Juanmartiñena Fernández, Ignacio Fernández-Urien Sainz, Beatriz Zabalza Ollo, Cristina Saldaña Dueñas, Marta Montañés Guimera, Alfonso Elosua González, Juan José Vila Costas
BACKGROUND: Capsule endoscopy was primarily designed for the investigation of the small bowel. However, it may also identify lesions in other segments of the gastrointestinal tract. The aim of the current study was to evaluate the incidence of gastroduodenal abnormalities during small bowel capsule endoscopy and its impact on patient diagnosis and management. PATIENTS AND METHODS: This study is a retrospective analysis of data from 2,217 consecutive capsule endoscopy procedures performed at a single tertiary-care center between January 2008 and February 2016...
November 20, 2017: Revista Española de Enfermedades Digestivas
https://www.readbyqxmd.com/read/29152989/real-time-visualization-may-be-advisable-to-exclude-aspiration-in-patients-undergoing-capsule-endoscopy-examination
#12
Davide Giuseppe Ribaldone, Mauro Bruno, Paolo Solidoro, Claudio De Angelis
Capsule endoscopy (CE) is currently considered as a first line diagnostic tool for small bowel examination. Some patients find swallowing the capsule difficult. However, capsule aspiration is relatively uncommon and is only reported in isolated cases. The majority of these cases are male (39/41; 95.1%) with an age ranging from 56-93 years and only 4 (9.8%) patients had a recorded history of dysphagia. Twenty-four out of 41 (58.5%) patients experienced symptoms of capsule aspiration. The aspiration self-resolved in 11/41 patients and the CE was retrieved during bronchoscopy in the other cases...
November 20, 2017: Revista Española de Enfermedades Digestivas
https://www.readbyqxmd.com/read/29152502/target-specific-deep-brain-stimulation-of-the-ventral-capsule-ventral-striatum-for-the-treatment-of-neuropsychiatric-disease
#13
Chencheng Zhang, Dianyou Li, Haiyan Jin, Kristina Zeljic, Bomin Sun
Deep brain stimulation (DBS) is a well-established therapy for Parkinson's disease and other movement disorders. An accumulating body of evidence supports the extension of DBS application for the treatment of refractory psychiatric disorders. The ventral capsule/ventral striatum (VC/VS) is the most common anatomical target for obsessive-compulsive disorder (OCD), addiction, and depression. However, no specific electrode is available for the clinical targeting of these areas for DBS. According to the anatomical features of the VC/VS, a novel electrode was developed for simultaneous and independently programmed stimulation of the nucleus accumbens (NAc) and the anterior limb of the internal capsule (ALIC)...
October 2017: Annals of Translational Medicine
https://www.readbyqxmd.com/read/29152307/coagulation-profile-of-sudanese-children-with-homozygous-sickle-cell-disease-and-the-effect-of-treatment-with-omega-3-fatty-acid-on-the-coagulation-parameters
#14
Shiekh Awoda, Ahmed A Daak, Nazik Elmalaika Husain, Kebreab Ghebremeskel, Mustafa I Elbashir
Background: It has been reported that patients with SCD do have an abnormal coagulation profile. Coagulopathy is thought to be one of the key factors that contribute to the vaso-occlusive crisis that characterises sickle cell disease (SCD). In this study, we investigated whether Sudanese sickle cell patients have an abnormal coagulation profile. In addition, the effect of treatment with either omega-3 fatty acids or hydroxyurea on coagulation profile was assessed. Methods: Homozygous SCD patients untreated (n = 52), omega-3 treated (n = 44), hydroxyurea (HU) treated (n = 8) and healthy (HbAA) controls (n = 52) matched for age (4-20 years), gender and socioeconomic status were enrolled...
2017: BMC Hematology
https://www.readbyqxmd.com/read/29152256/consumption-of-kiwifruit-capsules-increases-faecalibacterium-prausnitzii-abundance-in-functionally-constipated-individuals-a-randomised-controlled-human-trial
#15
Paul Blatchford, Halina Stoklosinski, Sarah Eady, Alison Wallace, Christine Butts, Richard Gearry, Glenn Gibson, Juliet Ansell
This study investigated the impact of ACTAZIN™ green (2400 and 600 mg) and Livaux™ (2400 mg) gold kiwifruit supplements on faecal microbial composition and metabolites in healthy and functionally constipated (FC) participants. The participants were recruited into the healthy group (n 20; one of whom did not complete the study) and the FC group (n 9), each of whom consumed all the treatments and a placebo (isomalt) for 4 weeks in a randomised cross-over design interspersed with 2-week washout periods. Modification of faecal microbiota composition and metabolism was determined by 16S rRNA gene sequencing and GC, and colonic pH was calculated using SmartPill(®) wireless motility capsules...
2017: Journal of Nutritional Science
https://www.readbyqxmd.com/read/29152243/effect-of-pomegranate-extract-on-blood-pressure-and-anthropometry-in-adults-a-double-blind-placebo-controlled-randomised-clinical-trial
#16
A Stockton, G Farhat, Gordon J McDougall, E A S Al-Dujaili
Pomegranate (Punica granatum), a polyphenol-rich fruit, has been suggested to reduce cardiovascular risk due to its antioxidant properties. Hypertension and obesity are the most preventable cardiovascular risk factors. Few studies on blood pressure and/or body-weight status have been conducted in human subjects. Previous investigations have tended to focus on pomegranate juice. The aim of the present study was to investigate the effect of pomegranate extract (PE) on blood pressure and anthropometric measures in adults with no symptomatic disease...
2017: Journal of Nutritional Science
https://www.readbyqxmd.com/read/29151891/the-exon-junction-complex-factor-y14-is-dynamic-in-the-nucleus-of-the-beetle-tribolium-castaneum-during-late-oogenesis
#17
Artem M Kiselev, Irina S Stepanova, Leonid S Adonin, Florina M Batalova, Vladimir N Parfenov, Dmitry S Bogolyubov, Olga I Podgornaya
Background: The oocyte chromosomes of the red flour beetle, Tribolium castaneum, are gathered into a knot, forming a karyosphere at the diplotene stage of meiotic prophase. Chromatin rearrangement, which is a characteristic feature of oocyte maturation, is well documented. The T. castaneum karyosphere is surrounded by a complex extrachromosomal structure termed the karyosphere capsule. The capsule contains the vast majority of oocyte RNA. We have previously shown using a BrUTP assay that oocyte chromosomes in T...
2017: Molecular Cytogenetics
https://www.readbyqxmd.com/read/29151695/efficacy-of-postoperative-adjuvant-transcatheter-arterial-chemoembolization-in-hepatocellular-carcinoma-patients-with-microvascular-invasion
#18
Jia-Zhou Ye, Jun-Ze Chen, Zi-Hui Li, Tao Bai, Jie Chen, Shao-Liang Zhu, Le-Qun Li, Fei-Xiang Wu
AIM: To investigate the efficacy and safety of postoperative adjuvant transcatheter arterial chemoembolization (PA-TACE) in preventing tumor recurrence and improving survival in Barcelona Clinic Liver Cancer (BCLC) early (A) and intermediate (B) stage hepatocellular carcinoma (HCC) patients with microvascular invasion (MVI). METHODS: A total of 519 BCLC A or B HCC patients treated by liver resection alone or followed by PA-TACE between January 2012 and December 2015 were studied retrospectively...
November 7, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/29151688/schockmed-valve-a-novel-surgical-option-for-uncontrolled-glaucoma-in-eyes-with-poor-conjunctiva-and-encircling-bands
#19
David Fleischman, Bryan Kim
Surgical management of elevated intraocular pressure (IOP) in an eye with scarred conjunctiva, an encircling band, and silicone oil has limited options. By combining the flow restrictor of the Ahmed Glaucoma Valve (New World Medical, Rancho Cucamonga, California) and the capsule of the encircling band as a conduit for aqueous flow, immediate pressure reduction could theoretically be achieved in eyes with limited conjunctival mobilization. This is a description of a surgical technique in a case of a patient with multiple ocular surgeries with uncontrolled multimechanism glaucoma despite using all available topical and oral glaucoma medications...
September 2017: Journal of Current Glaucoma Practice
https://www.readbyqxmd.com/read/29151395/tziminema-unachi-n-gen-n-sp-nematoda-strongylidae-strongylinae-parasite-of-baird-s-tapir-tapirus-bairdii-from-mexico
#20
D M Güiris-Andrade, A Oceguera-Figueroa, D Osorio-Sarabia, M E Pérez-Escobar, M G Nieto-López, N M Rojas-Hernández, L García-Prieto
A new genus and species of nematode, Tziminema unachi n. gen., n. sp. is described from the caecum and colon of Baird's tapir Tapirus bairdii (Gill, 1865), found dead in the Reserva de la Biósfera El Triunfo, Chiapas State, in the Neotropical realm of Mexico. Tziminema n. gen. differs from the other nine genera included in the Strongylinae by two main characteristics: having 7-9 posteriorly directed tooth-like structures at the anterior end of the buccal capsule, and the external surface of the buccal capsule being heavily striated...
November 20, 2017: Journal of Helminthology
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