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https://www.readbyqxmd.com/read/27785332/epstein-barr-virus-positive-diffuse-large-b-cell-lymphoma-involving-the-colon-in-a-patient-with-ulcerative-pancolitis-and-polymyositis-on-long-term-methotrexate-therapy
#1
Michael D Chang, Merry-Jennifer Markham, Xiuli Liu
The link between immunosuppressive therapy and increased lymphoma risk is well established in patients with solid organ transplantation. Epstein-Barr virus-positive (EBV) diffuse large B-cell lymphoma (DLBCL) is known to be a complication in patients receiving methotrexate for rheumatoid arthritis, and the risk of lymphoma in inflammatory bowel disease (IBD) has raised concerns regarding the lymphoproliferative potential of immunomodulatory therapy. In this report, we describe a case of EBV-positive DLBCL arising within the colon of a patient affected by ulcerative pancolitis...
October 2016: Gastroenterology Research
https://www.readbyqxmd.com/read/27782890/pediatric-small-bowel-transplantation-a-single-center-experience-from-turkey
#2
Cem Tuğmen, Maşallah Baran, İsmail Sert, Ayşe Berna Anıl, Eyüp Kebapçı, Sait Murat Doğan, Selçuk Kılınç, Gaye Aydın, Ayşe Gülden Diniz, Mustafa Ölmez, İbrahim Pirim, Cezmi Karaca
BACKGROUND/AIMS: Small bowel transplantation (SBTx) is a treatment option for patients with serious parenteral nutrition-related problems in intestinal failure. İzmir Tepecik Training Research Hospital Organ Transplantation Center is still the only pediatric intestinal transplant center in Turkey. MATERIAL AND METHODS: This study was approved by the local ethics committee. Patients' data were analyzed from the medical charts and the hospital digital database. Seven isolated SBTxs were performed in six children between 2010 and 2016...
September 2016: Turkish Journal of Gastroenterology: the Official Journal of Turkish Society of Gastroenterology
https://www.readbyqxmd.com/read/27582272/allograft-biopsy-findings-in-patients-with-small-bowel-transplantation
#3
Jamie Koo, David W Dawson, Sarah Dry, Samuel W French, Bita V Naini, Hanlin L Wang
In this study, we sought to determine the incidence of posttransplant complications including acute cellular rejection (ACR), infection, and posttransplant lymphoproliferative disease (PTLD) in mucosal allograft biopsies in patients with small bowel transplant at our institution. We retrospectively reviewed pathology reports from 5675 small bowel allograft biopsies from 99 patients and analyzed the following: indications for biopsy, frequency and grade of ACR, presence of infectious agents, results of work-up for potential PTLD, results of C4d immunohistochemistry (IHC), features of chronic mucosal injury, and findings in concurrent native bowel biopsies...
September 1, 2016: Clinical Transplantation
https://www.readbyqxmd.com/read/27554218/a-case-of-ulcerative-colitis-following-acute-hepatitis-induced-by-epstein-barr-virus-infection
#4
Seung Hyun Oh, Chan Ran You, Eun Ok Kim, Si Hyun Bae, Jong Young Choi, Seung Kew Yoon, Sang Wook Choi
Epstein-Barr virus (EBV) infection varies in its clinical manifestations and severity. EBV can be a causative agent of hepatitis and may have a role in the pathogenesis of chronic autoimmune diseases including inflammatory bowel disease. A 24-year-old woman was admitted to our hospital, presenting with fever and elevated liver enzymes. She was diagnosed with acute hepatitis and EBV infection according to serologic tests and liver biopsy. Within two months, she was re-admitted to our hospital, presenting with hematochezia and lower abdominal pain...
August 25, 2016: Korean Journal of Gastroenterology, Taehan Sohwagi Hakhoe Chi
https://www.readbyqxmd.com/read/27416006/how-genetic-testing-can-lead-to-targeted-management-of-xiap-deficiency-related-inflammatory-bowel-disease
#5
Ole Haagen Nielsen, Eric Charles LaCasse
X-linked lymphoproliferative disease type 2 (XLP-2, OMIM 300635) is a primary immunodeficiency caused by the loss of X chromosome-linked inhibitor of apoptosis (XIAP), the X-linked inhibitor of apoptosis gene at Xq25. XLP-2 individuals are susceptible to several specific and potentially fatal infections, such as Epstein-Barr virus (EBV). Children with XIAP-related XLP-2 may present with either familial hemophagocytic lymphohistiocytosis, often triggered in response to EBV infection, or with a treatment-refractory severe pediatric form of inflammatory bowel disease (IBD) that might be diagnosed as Crohn disease...
July 14, 2016: Genetics in Medicine: Official Journal of the American College of Medical Genetics
https://www.readbyqxmd.com/read/27106672/systemic-delivery-of-il-27-by-an-adeno-associated-viral-vector-inhibits-t-cell-mediated-colitis-and-induces-multiple-inhibitory-pathways-in-t-cells
#6
Xiaotong Zhu, Zhihao Liu, Jin-Qing Liu, Jianmin Zhu, Jianchao Zhang, Jonathan P Davis, Jianhong Chu, Jianhua Yu, Jie Zhou, Ming-Song Li, Xue-Feng Bai
IL-27 is a heterodimeric cytokine that is composed of two subunits, i.e., EBV-induced gene 3 and IL-27p28 (also known as IL-30). Although the role of endogenous IL-27 in the pathogenesis of autoimmune colitis, an experimental model of human inflammatory bowel disease, remains controversial, IL-27 local delivery has been shown to inhibit autoimmune colitis. IL-30 has been shown to inhibit Th1 and Th17 responses and is considered a potential therapeutic for certain autoimmune diseases. In this study, we have compared the therapeutic efficacy of adeno-associated viral vector-delivered IL-27 and IL-30 in a murine model of autoimmune colitis...
August 2016: Journal of Leukocyte Biology
https://www.readbyqxmd.com/read/27093448/ebv-associated-peripheral-t-cell-lymphoma-of-gastrointestinal-tract-presented-with-widespread-chronic-inflammation-a-case-report
#7
Guldeep Uppal, Alaina Chodoff, Zi-Xuan Wang, Jeffrey P Baliff, Marina Domingo-Vidal, Ubaldo E Martinez-Outschoorn, Dennis P O'Malley, Jerald Z Gong
We report a case of Epstein-Barr virus (EBV)-associated T-cell lymphoma of gastrointestinal (GI) tract from a 70-year-old white woman who initially presented with a widespread GI inflammation and gastric obstruction. Initial biopsies of the GI tract showed severe chronic inflammation in the esophagus, stomach, and the small intestine. Celiac disease and inflammatory bowel disease were ruled out. The patient was treated with partial gastrectomy. Histology showed gastric wall thickening with EBV-positive, mixed lymphocytic and plasma cell infiltration in the mucosa, and thickening and fibrosis of the submucosa...
April 16, 2016: Applied Immunohistochemistry & Molecular Morphology: AIMM
https://www.readbyqxmd.com/read/27015206/a-case-report-of-nk-cell-lymphoproliferative-disease-with-a-wide-involvement-of-digestive-tract-develop-into-epstein-barr-virus-associated-nk-t-cell-lymphoma-in-an-immunocompetent-patient
#8
Haotian Chen, Yu Zhang, Zhinong Jiang, Wei Zhou, Qian Cao
Epstein-Barr virus (EBV) plays an important role in various diseases. EBV-associated lymphoproliferative disease (LPD) is a rare disease with a canceration tendency. It is difficult to differentiate LPD with involvement of digestive tract from Crohn disease due to similar clinical and endoscopic manifestations. We present a case report of multiple ulcers with esophagus, small bowel and the entire colon involved, proved to be NK-Cell LPD, developed into EBV-associated NK/T Cell lymphoma, in an immunocompetent man who was initially misdiagnosed as Crohn disease...
March 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/26844502/epstein-barr-virus-positive-t-nk-cell-lymphoproliferative-disorders-manifested-as-gastrointestinal-perforations-and-skin-lesions-a-case-report
#9
Hai-Juan Xiao, Ji Li, Hong-Mei Song, Zheng-Hong Li, Mei Dong, Xiao-Ge Zhou
Systemic Epstein-Barr virus (EBV)-positive T-cell lymphoproliferative disorders (LPDs) of childhood is a highly aggressive EBV-positive T/natural killer (NK)-cell LPD, which emerges in the background of chronic active EBV infection (CAEBV) or shortly after primary acute EBV infection. The clinical presentations of CAEBV are varied; patients with atypical manifestations are easily misdiagnosed. We described a 14-year-old boy suffering from digestive disorders and intermittent fever for 1 year and 9 months, whose conditions worsened and skin lesions occurred 2 months before hospitalization...
February 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/26659090/differential-cellular-localization-of-epstein-barr-virus-and-human-cytomegalovirus-in-the-colonic-mucosa-of-patients-with-active-or-quiescent-inflammatory-bowel-disease
#10
Rachele Ciccocioppo, Francesca Racca, Luigia Scudeller, Antonio Piralla, Pietro Formagnana, Lodovica Pozzi, Elena Betti, Alessandro Vanoli, Roberta Riboni, Peter Kruzliak, Fausto Baldanti, Gino Roberto Corazza
The role of human cytomegalovirus (HCMV) and Epstein-Barr virus (EBV) in the exacerbation of inflammatory bowel disease (IBD) is still uncertain. We prospectively investigated the presence of EBV and HCMV infection in both epithelial and immune cells of colonic mucosa of IBD patients, both refractory and responders to standard therapies, in comparison with patients suffering from irritable bowel syndrome who were considered as controls, by using quantitative real-time polymerase chain reaction, immunohistochemistry and in situ hybridization, in an attempt to assess viral localization, DNA load, life cycle phase and possible correlation with disease activity indexes...
February 2016: Immunologic Research
https://www.readbyqxmd.com/read/26600976/lymphoproliferative-disorders-in-inflammatory-bowel-disease-patients-on-immunosuppression-lessons-from-other-inflammatory-disorders
#11
REVIEW
Grace Y Lam, Brendan P Halloran, Anthea C Peters, Richard N Fedorak
Immunosuppressive agents, such as thiopurines, methotrexate, and biologics, have revolutionized the treatment of inflammatory bowel disease (IBD). However, a number of case reports, case control studies and retrospective studies over the last decade have identified a concerning link between immunosuppression and lymphoproliferative disorders (LPDs), the oncological phenomenon whereby lymphocytes divide uncontrollably. These LPDs have been associated with Epstein-Barr virus (EBV) infection in which the virus provides the impetus for malignant transformation while immunosuppression hampers the immune system's ability to detect and clear these malignant cells...
November 15, 2015: World Journal of Gastrointestinal Pathophysiology
https://www.readbyqxmd.com/read/26307954/anti-tnf%C3%AE-therapy-for-inflammatory-bowel-diseases-is-associated-with-epstein-barr-virus-lytic-activation
#12
Sameer Lapsia, Siva Koganti, Salvatore Spadaro, Ramona Rajapakse, Anupama Chawla, Sumita Bhaduri-McIntosh
Anti-TNFα therapy, known to suppress T-cell immunity, is increasingly gaining popularity for treatment of autoimmune diseases including inflammatory bowel diseases (IBD). T-cell suppression increases the risk of B-cell EBV-lymphoproliferative diseases and lymphomas. Since EBV-lytic activation is essential for development of EBV-lymphomas and there have been reports of EBV-lymphomas in patients treated with anti-TNFα therapy, we investigated if patients treated with anti-TNFα antibodies demonstrate greater EBV-lytic activity in blood...
February 2016: Journal of Medical Virology
https://www.readbyqxmd.com/read/26277577/infection-is-the-major-trigger-of-hemophagocytic-syndrome-in-adult-patients-treated-with-biological-therapies
#13
Pilar Brito-Zerón, Xavier Bosch, Marta Pérez-de-Lis, Roberto Pérez-Álvarez, Guadalupe Fraile, Hoda Gheitasi, Soledad Retamozo, Albert Bové, Ester Monclús, Ona Escoda, Asunción Moreno, Armando López-Guillermo, Munther A Khamashta, Manuel Ramos-Casals
INTRODUCTION: Hemophagocytic syndromes (hemophagocytic lymphohistiocytosis, HLH) are characterized by a wide range of etiologies, symptoms, and outcomes, but have a common etiopathogenic pathway leading to organ damage: an excessive inflammatory response. Biological therapies have been proposed as a therapeutic option for refractory HLH, but have also been related to the development of HLH in severe immunosuppressed patients. OBJECTIVES AND METHODS: The purpose of this study was to analyze the clinical characteristics and outcomes of adult patients who developed HLH after receiving biological therapies...
February 2016: Seminars in Arthritis and Rheumatism
https://www.readbyqxmd.com/read/26091801/seroprevalence-of-epstein-barr-virus-cytomegalovirus-and-polyomaviruses-in-children-with-inflammatory-bowel-disease
#14
Ondrej Hradsky, Ivana Copova, Kristyna Zarubova, Marianna Durilova, Jiri Nevoral, Miroslav Maminak, Petr Hubacek, Jiri Bronsky
BACKGROUND: Young age and thiopurine therapy are risk factors for lymphoproliferative disease among patients with inflammatory bowel disease (IBD). AIMS: The aims of this study were to evaluate the prevalence of seropositivity for the Epstein-Barr virus (EBV) and human cytomegalovirus (CMV) among children and adolescents with IBD, to assess the viral load of EBV, CMV, and BK and JC polyomaviruses (BKV, JCV) in these patients, and to assess the influence of different therapeutic regimens on seroprevalence and viral load...
November 2015: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/26019475/epstein-barr-virus-positive-mucocutaneous-ulcer-of-the-colon-associated-hodgkin-lymphoma-in-crohn-s-disease
#15
Neil R Moran, Bradley Webster, Kenneth M Lee, Judith Trotman, Yiu-Lam Kwan, John Napoli, Rupert W Leong
Epstein Barr virus (EBV) positive mucocutaneous ulcers (EBVMCU) form part of a spectrum of EBV-associated lymphoproliferative disease. They have been reported in the setting of immunosenescence and iatrogenic immunosuppression, affecting the oropharyngeal mucosa, skin and gastrointestinal tract (GIT). Case reports and series to date suggest a benign natural history responding to conservative management, particularly in the GIT. We report an unusual case of EBVMCU in the colon, arising in the setting of immunosuppression in the treatment of Crohn's disease, with progression to Hodgkin lymphoma 18 mo after cessation of infliximab...
May 21, 2015: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/25740811/epstein-barr-virus-in-inflammatory-bowel-disease-the-spectrum-of-intestinal-lymphoproliferative-disorders
#16
Loes H C Nissen, Iris D Nagtegaal, Dirk J de Jong, Wietske Kievit, Lauranne A A P Derikx, Patricia J T A Groenen, J Han J M van Krieken, Frank Hoentjen
BACKGROUND: Inflammatory bowel disease (IBD) patients on thiopurine therapy are at increased risk of Epstein-Barr virus (EBV)-associated lymphomas. This virus is frequently detected in the intestinal mucosa of IBD patients and may cause a wide spectrum of lymphoproliferations similar to post-transplantation lymphoproliferative disorders (PTLDs). We aimed to assess whether histological aberrations aid in predicting EBV presence and to correlate histological assessment and EBV load with disease outcome in IBD...
May 2015: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/25737324/x-linked-inhibitor-of-apoptosis-protein-deficiency-more-than-an-x-linked-lymphoproliferative-syndrome
#17
REVIEW
Claire Aguilar, Sylvain Latour
X-linked inhibitor of apoptosis (XIAP) deficiency (also known as X-linked lymphoproliferative syndrome type 2, XLP-2) is a rare primary immunodeficiency. Since the disease was first described in 2006, more than 70 patients suffering from XIAP-deficiency have been reported, thus extending the clinical presentations of the disease. The main clinical features of XLP-2 are (i) elevated susceptibility to hemophagocytic lymphohistiocytosis (HLH, frequently in response to infection with Epstein-Barr virus (EBV)), (ii) recurrent splenomegaly and (iii) inflammatory bowel disease (IBD) with the characteristics of Crohn's disease...
May 2015: Journal of Clinical Immunology
https://www.readbyqxmd.com/read/25684960/human-cytomegalovirus-and-epstein-barr-virus-infection-in-inflammatory-bowel-disease-need-for-mucosal-viral-load-measurement
#18
COMPARATIVE STUDY
Rachele Ciccocioppo, Francesca Racca, Stefania Paolucci, Giulia Campanini, Lodovica Pozzi, Elena Betti, Roberta Riboni, Alessandro Vanoli, Fausto Baldanti, Gino Roberto Corazza
AIM: To evaluate the best diagnostic technique and risk factors of the human Cytomegalovirus (HCMV) and Epstein-Barr virus (EBV) infection in inflammatory bowel disease (IBD). METHODS: A cohort of 40 IBD patients (17 refractory) and 40 controls underwent peripheral blood and endoscopic colonic mucosal sample harvest. Viral infection was assessed by quantitative real-time polymerase chain reaction and immunohistochemistry, and correlations with clinical and endoscopic indexes of activity, and risk factors were investigated...
February 14, 2015: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/25678011/primary-lymphomas-in-the-gastrointestinal-tract
#19
REVIEW
Jiang Chen Peng, Lu Zhong, Zhi Hua Ran
Primary gastrointestinal (GI) lymphomas are uncommon diseases that can involve the whole GI tract. The etiologies of the disease remain unclear, and potential risk factors include celiac disease, Helicobacter pylori infection, use of immunosuppressive agents, human immunodeficiency virus (HIV) or Epstein-Barr virus (EBV) infection and inflammatory bowel disease, etc. Diffuse large B-cell lymphoma (DLBCL) and mucosa-associated lymphoid tissue (MALT) lymphoma are the most common subtypes of GI lymphomas. B-cell lymphomas of the GI tract are more common in Western countries, while in Asia-Pacific region T-cell lymphomas are more frequently reported...
April 2015: Journal of Digestive Diseases
https://www.readbyqxmd.com/read/25666262/xiap-deficiency-syndrome-in-humans
#20
REVIEW
Sylvain Latour, Claire Aguilar
The X-linked inhibitor of apoptosis (XIAP) deficiency, also known as the X-linked lymphoproliferative syndrome type 2 (XLP-2), is a rare primary immunodeficiency. XIAP deficiency is characterized by a key triad of clinical manisfestations, which consist of a high susceptibility to develop hemophagocytic lymphohistiocytosis (HLH) frequently triggered by Epstein-Barr virus (EBV) infection, recurrent splenomegaly and inflammatory bowel disease (IBD) with the features of a Crohn's disease. XIAP deficiency can be considered as one of the genetic causes for inherited IBD...
March 2015: Seminars in Cell & Developmental Biology
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