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Marija Kocic, Slavisa M Djuricic, Maja Djordjevic, Djordje Savic, Bozica Kecman, Adrijan Sarajlija
Almost any anatomical compartment may be involved in Gaucher disease (GD). Abdominal lymphadenopathy occurred during enzyme replacement therapy in more than a dozen children with GD so far. A fourteen-year-old boy from Serbia developed clinical signs of acute appendicitis six years after the onset of GD type 3 related abdominal lymphadenopathy. Ultrasound examination showed diffuse thickening of the intestinal wall in the ileocoecal region with periappendicular infiltration. An appendectomy was performed four months after conservative treatment with antibiotics...
September 30, 2016: Blood Cells, Molecules & Diseases
Ivana Varenina, Nina Bilandžić, Božica Solomun Kolanović, Đurđica Božić, Marija Sedak, Maja Đokić, Ines Varga
A quantitative multi-residue method that includes 13 sulfonamides, trimethoprim and dapsone was developed and validated according to Commission Decision 2002/657/EC for muscle, milk egg and honey samples. For all matrices, the same extraction procedure was used. Samples were extracted with an acetone/dichloromethane mixture and cleaned up on aromatic sulfonic acid (SO3H) SPE cartridges. After elution and concentration steps, analytes were identified and quantified by liquid chromatography-tandem mass spectrometry (LC-MS/MS)...
2016: Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment
Nina Bilandžić, Marija Sedak, Bruno Čalopek, Đurđica Božić Luburić, Božica Solomun Kolanović, Ivana Varenina, Maja Đokić, Ivana Kmetič, Teuta Murati
A total of 249 cow and 33 goat milk samples were collected in rural areas of Croatia during the period 2010-2014. Lead concentrations in milk samples were analyzed by graphite furnace-atomic absorption spectroscopy. Mean Pb concentrations in milk ranged from (μg/kg): cow 10.8-12.2; goat 9.33-60.0. The highest Pb level of 131 μg/kg in cow milk was measured during 2014. There were no significant differences in Pb levels between cow and goat milk and also in goat milk among the analysed years. However, significant differences were found in cow milk among years...
May 2016: Bulletin of Environmental Contamination and Toxicology
M Stojiljkovic, K Klaassen, M Djordjevic, A Sarajlija, S Brasil, B Kecman, S Grkovic, J Kostic, P Rodriguez-Pombo, L R Desviat, S Pavlovic, B Perez
Specific mitochondrial enzymatic deficiencies in the catabolism of branched-chain amino acids cause methylmalonic aciduria (MMA), propionic acidemia (PA) and maple syrup urine disease (MSUD). Disease-causing mutations were identified in nine unrelated branched-chain organic acidurias (BCOA) patients. We detected eight previously described mutations: p.Asn219Tyr, p.Arg369His p.Val553Glyfs*17 in MUT, p.Thr198Serfs*6 in MMAA, p.Ile144_Leu181del in PCCB, p.Gly288Valfs*11, p.Tyr438Asn in BCKDHA and p.Ala137Val in BCKDHB gene...
September 2016: Clinical Genetics
Adrijan Sarajlija, Tatjana Milenkovic, Maja Djordjevic, Katarina Mitrovic, Sladjana Todorovic, Bozica Kecman, Khalid Hussain
Hyperinsulinism/hyperammonemia (HI/HA) syndrome is considered as the second most common type of hereditary HI. Correlation of genotype and phenotype in HI/HA syndrome has been described in several studies. We present three Serbian patients with HI/HA syndrome with emphasis on a possible correlation between genotype and clinical manifestations. Patient 1 was heterozygous for a de novo mutation p.S445L in the GLUD1 gene, while patients 2 and 3 (son and mother) both carry the p.R221C mutation. Early onset of hypoglycaemia with generalized seizures was recorded in infancy in all three patients...
June 5, 2016: Journal of Clinical Research in Pediatric Endocrinology
Suzana Žunec, Božica Radić, Kamil Kuča, Kamil Musilek, Ana Lucić Vrdoljak
The inability of standard therapy to provide adequate protection against poisoning by organophosphorus compounds (pesticides and nerve agents) motivated us to search for new, more effective oximes. We investigated the pharmacotoxicological properties of six experimental K-oximes (K027, K033, K048, K074, K075, and K203) in vivo. The therapeutic efficacy of K-oximes (at doses of 5 or 25 % of their LD50) combined with atropine was assessed in paraoxon-poisoned mice and compared with conventionally used oximes HI-6 and TMB-4...
June 2015: Arhiv za Higijenu Rada i Toksikologiju
Nathalie Jazmati, Pia Wiegel, Božica Ličanin, Georg Plum
We compared the Qiagen artus C. difficile QS-RGQ kit, a new nucleic acid amplification test for the detection of Clostridium difficile toxins in stool specimens, with the Cepheid Xpert C. difficile test. The sensitivity, specificity, positive predictive value, and negative predictive value for the Qiagen artus C. difficile QS-RGQ test were 100%, 89.5%, 60.9%, and 100%, and those for the Cepheid Xpert C. difficile test were 100%, 90%, 62.2%, and 100%, respectively.
June 2015: Journal of Clinical Microbiology
Nina Bilandžić, Đurđica Božić, Božica Solomun Kolanović, Ivana Varenina, Luka Cvetnić, Željko Cvetnić
The distribution of sulfamonomethoxine (SMM) and trimethoprim (TMP) in egg yolk and white was measured during and after administration of a SMM/TMP combination in laying hens in doses of 8 g l(-)(1) and 12 g l(-)(1) in drinking water for 7 days. The SMM concentration reached maximal levels on day 2 of the post-treatment period for both doses (μg kg(-)(1)): 5920 and 9453 in yolk; 4831 and 6050 in white, in doses 1 and 2, respectively. Significant differences in the SMM and TMP concentrations between yolk and white in post treatment period were found...
July 1, 2015: Food Chemistry
Ivana Varenina, Nina Bilandžić, Luka Cvetnić, Blaženka Kos, Đurđica Božić, Božica Solomun Kolanović, Željko Cvetnić
The coccidiostat maduramicin has been approved as a feed additive for chickens and turkeys, although it is prohibited for use in laying hens. In the present study, laying hens were divided into three groups and fed for 14 days with medicated feed containing maduramicin, at three different concentrations: 50, 100 and 500 µg kg(-1). Eggs were collected during treatment and for 26 days after the end of feeding with medicated feed. Maduramicin residues were found exclusively in egg yolk, with the highest concentration in egg yolk of 459 µg kg(-1) for the highest dose...
2015: Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment
Maja Stojiljkovic, Kristel Klaassen, Maja Djordjevic, Adrijan Sarajlija, Bozica Kecman, Milena Ugrin, Branka Zukic, Lourdes R Desviat, Sonja Pavlovic, Belen Perez
Hyperphenylalaninemia (HPA) [phenylketonuria (PKU) and tetrahydrobiopterin (BH4) deficiencies] is rare inborn metabolic disease characterized by elevated phenylalanine level in body fluids. In Serbia, 62 HPA patients have been identified through newborn screening since 1983. However, pterin pattern analysis is not performed. We present a patient initially diagnosed and treated as classical PKU. At 3 years of age, during infection with H1N1 influenza A virus, the patient first developed a neurologic crisis with encephalopathy and dystonic movements...
March 2015: Journal of Pediatric Endocrinology & Metabolism: JPEM
Nina Bilandžić, Jožica Dolenc, Ksenija Šinigoj Gačnik, Ivana Varenina, Božica Solomun Kolanović
In total 307 egg and 275 liver samples were examined for nicarbazin and 365 eggs for diclazuril over a 30-month period. Enzyme-linked immunosorbent assay methods used for quantification were validated according to European Commission Decision 2002/657/EC. Non-compliant samples were confirmed by LC-MS/MS. Mean diclazuril concentrations in egg samples were 0.31 µg kg⁻¹, which is below the MRL. In only one egg sample, 2.26 µg kg⁻¹ was determined by enzyme-linked immunosorbent assay, although confirmation by LC-MS/MS gave a value of 1...
2013: Food Additives & Contaminants. Part B, Surveillance
Anamarija Jurcev-Savicevic, Rosanda Mulic, Bozica Ban, Karlo Kozul, Ljiljana Bacun-Ivcek, Jasna Valic, Gordana Popijac-Cesar, Snjezana Marinovic-Dunatov, Majda Gotovac, Aleksandar Simunovic
BACKGROUND: Mycobacterium tuberculosis is a necessary, but not sufficient, cause of tuberculosis. A number of studies have addressed the issue of risk factors for tuberculosis development. Croatia is a European country with an incidence rate of 14/100 000 which is slowly decreasing. The aim of this study is to evaluate the potential demographic, socioeconomic, behavioural and biological risk factors for tuberculosis in Croatia in comparison to other high-income, low-incidence European countries...
2013: BMC Public Health
Božica S Kolanović, Nina Bilandžić, Ivana Varenina, Durđica Božić
A total of 646 meat and 96 honey samples were examined over a 2-year period for the presence of tylosin residues. ELISA method used was validated according to the criteria of Commission Decision 2002/657/EC established for qualitative screening methods. The CCβ values were 32.1 µg kg⁻¹ in muscle and 24.4 µg kg⁻¹ in honey. The recoveries from spiked samples ranged from 66.4-118.6%, with a coefficient of variation between 12.6% and 18.6%. All the investigated samples showed no presence of tylosin. Calculated estimated daily intakes show exposure levels lower than the acceptable daily intakes set by World Health Organization...
2014: Journal of Immunoassay & Immunochemistry
Ana Lucić Vrdoljak, Suzana Žunec, Božica Radić, Radovan Fuchs, Davor Želježić, Nevenka Kopjar
This study investigates the effects of oxime K048 (730, 200, and 7.3nM) on the viability and chromosome stability of human peripheral blood lymphocytes (PBLs) after a 30min exposure in vitro. Cytotoxicity was tested by a viability assay with ethidium bromide and acridine orange. For the evaluation of the genotoxic potential, we used comet assays, cytokinesis-blocked micronucleus (CBMN) assay, and chromosome aberration (CA) analysis. We found acceptable cytotoxicity for K048 (9.7±2.1% non-viable PBL at highest concentration vs...
February 2014: Toxicology in Vitro: An International Journal Published in Association with BIBRA
Stoimir Kolarević, Jelena Knežević-Vukčević, Momir Paunović, Margareta Kračun, Božica Vasiljević, Jelena Tomović, Branka Vuković-Gačić, Zoran Gačić
This study was undertaken to investigate the potential of the freshwater mussel Sinanodonta woodiana for detection of genotoxic pollution of the environment. Study was performed at two sites in the Velika Morava River, from May 2010 to February 2011. The alkaline comet assay on haemocytes was used, and the olive tail moment (OTM) was chosen as a measure of DNA damage. The specimens held on acclimation under controlled laboratory conditions for 10d were used as a control. Chemical analysis revealed the presence of phosphates and increased concentrations of zinc, copper and nickel at both sites during the entire sampling period...
September 2013: Chemosphere
Dusanka Dobanovacki, Milan Breberina, Bozica Vujosević, Marija Pećanac, Nenad Zakula, Velicko Trajković
INTRODUCTION: In the mid-twentieth century, the health care of women and children was inadequate in the post-war Yugoslavia, including the city of Novi Sad, due to the severe post-war reality: poverty in the devastated country, shortage of all commodities and services and especially of medical supplies, equipment and educated staff. OUT-OF-HOSPITAL MATERNITY UNIT: One of the serious problems was parturition at home and morbidity and mortality of the newborns and women. Soon after the World War II the action programme of improving the women's health was realized on the state level by establishing out-of-hospital maternity units but under the expert supervision...
January 2013: Medicinski Pregled
Anamarija Jurcev-Savicevic, Rosanda Mulic, Karlo Kozul, Bozica Ban, Jasna Valic, Ljiljana Bacun-Ivcek, Ivan Gudelj, Gordana Popijac-Cesar, Snjezana Marinovic-Dunatov, Aleksandar Simunovic
BACKGROUND: Delayed diagnosis and treatment of tuberculosis increase both the severity of the disease and the duration of infectivity. A number of studies have addressed the issue of health system delays in the treatment of tuberculosis, but mostly in countries with a high or low incidence of the disease. Our understanding of delay is quite limited in settings with an intermediate burden of tuberculosis. We explore the duration and factors associated with delays in the Croatian health system which has free health care and a sufficient network of health services providing tuberculosis diagnosis and care...
2013: BMC Public Health
Maja Djordjevic, Kristel Klaassen, Adrijan Sarajlija, Natasa Tosic, Branka Zukic, Bozica Kecman, Milena Ugrin, Vesna Spasovski, Sonja Pavlovic, Maja Stojiljkovic
Phenylketonuria (PKU) is caused by mutations in the gene encoding phenylalanine hydroxylase (PAH) enzyme. Here, we report the updated spectrum of PAH mutations in 61 Serbian PKU patients. By using both DGGE/DNA sequencing and PCR-RFLP, we identified 26 disease-causing mutations (detection rate 99%). The most frequent ones were p.L48S (31%), p.R408W (16.4%), p.P281L (6%), p.E390G (5.2%), and p.I306V (5.2%). Homozygosity value indicated high heterogeneity of Serbian population.To overcome possible pitfalls of patients' phenotypic classification, we used two parameters: pretreatment/maximal phenylalanine blood concentration and Phe tolerance...
2013: JIMD Reports
Bozica Vrabec Branica, Inja Neralić Meniga, Igor Puljić, Ante Marusić, Nabil Chalfe, Antonija Ivicević
Metastases to the breast from extramammary neoplasms are very rare. Correct diagnosis of breast malignancy is important for establishing appropriate management and for avoiding unnecessary radical surgery. Metastasized breast malignancies from non-small cell lung carcinoma are extremely rare. Here we report a 55-year old female patient with breast metastasis from lung adenocarcinoma which was diagnosed with fine needle aspiration cytology and confirmed by immunocytochemistry.
December 2012: Collegium Antropologicum
Zoran Radić, Trevor Dale, Zrinka Kovarik, Suzana Berend, Edzna Garcia, Limin Zhang, Gabriel Amitai, Carol Green, Božica Radić, Brendan M Duggan, Dariush Ajami, Julius Rebek, Palmer Taylor
In the present paper we show a comprehensive in vitro, ex vivo and in vivo study on hydrolytic detoxification of nerve agent and pesticide OPs (organophosphates) catalysed by purified hBChE (human butyrylcholinesterase) in combination with novel non-pyridinium oxime reactivators. We identified TAB2OH (2-trimethylammonio-6-hydroxybenzaldehyde oxime) as an efficient reactivator of OP-hBChE conjugates formed by the nerve agents VX and cyclosarin, and the pesticide paraoxon. It was also functional in reactivation of sarin- and tabun-inhibited hBChE...
February 15, 2013: Biochemical Journal
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