keyword
MENU ▼
Read by QxMD icon Read
search

Superior colliculus

keyword
https://www.readbyqxmd.com/read/29333474/saccades-in-progressive-supranuclear-palsy-maladapted-irregular-curved-and-slow
#1
Aasef G Shaikh, Stewart A Factor, Jorge Juncos
Background and objectives: Slowed and curved rapid eye movements, saccades, are the well-known features of progressive supranuclear palsy (PSP). We hypothesized that the saccades in PSP are not only slow and curved, but they are also irregular and have timing deficits. Methods: We tested this hypothesis in 12 patients with PSP by measuring vertical and horizontal visually guided saccades using a limbus tracker. Results: Both, horizontal and vertical saccades were slow and had irregular trajectory and velocity profiles, but deficits were much more robust in vertical saccades...
September 2017: Movement Disorders Clinical Practice
https://www.readbyqxmd.com/read/29315552/projections-of-three-subcortical-visual-centres-to-marmoset-lateral-geniculate-nucleus
#2
Natalie Zeater, Péter Buzás, Bogdan Dreher, Ulrike Grünert, Paul R Martin
The dorsal lateral geniculate nucleus receives projections from visuotopically organised subcortical nuclei, in addition to inputs from the retina, visual cortices, and the thalamic reticular nucleus. Here, we study subcortical projections to the geniculate from the superior colliculus (SC) and parabigeminal nucleus (PBG) in the midbrain, and the nucleus of the optic tract (NOT) in the pretectum of marmosets. Marmosets are New World diurnal foveate monkeys, and are an increasingly popular model for studying the primate visual system...
January 9, 2018: Journal of Comparative Neurology
https://www.readbyqxmd.com/read/29302743/gabaergic-and-non-gabaergic-projections-to-the-superior-colliculus-from-the-auditory-brainstem
#3
Jeffrey G Mellott, Nichole L Beebe, Brett R Schofield
The superior colliculus (SC) contains an auditory space map that is shaped by projections from several subcortical auditory nuclei. Both GABAergic (inhibitory) and excitatory cells contribute to these inputs, but there are contradictory reports regarding the sources of these inputs. We used retrograde tracing techniques in guinea pigs to identify cells in the auditory brainstem that project to the SC. We combined retrograde tracing with immunohistochemistry for glutamic acid decarboxylase (GAD) to identify putative GABAergic cells that participate in this pathway...
January 4, 2018: Brain Structure & Function
https://www.readbyqxmd.com/read/29301105/how-the-midbrain-helps-us-decide
#4
Vincent B McGinty
In an elegant synthesis of behavior, modeling, and neurophysiology, Crapse et al. (2018) show that neurons of the superior colliculus influence choice behavior by encoding choice criterion, a quantitative measure of decision bias integral to signal detection theory.
January 3, 2018: Neuron
https://www.readbyqxmd.com/read/29301100/a-role-for-the-superior-colliculus-in-decision-criteria
#5
Trinity B Crapse, Hakwan Lau, Michele A Basso
Simple decisions arise from the evaluation of sensory evidence. But decisions are determined by more than just evidence. Individuals establish internal decision criteria that influence how they respond. Where or how decision criteria are established in the brain remains poorly understood. Here, we show that neuronal activity in the superior colliculus (SC) predicts changes in decision criteria. Using a novel "Yes-No" task that isolates changes in decision criterion from changes in decision sensitivity, and computing neuronal measures of sensitivity and criterion, we find that SC neuronal activity correlates with the decision criterion regardless of the location of the choice report...
January 3, 2018: Neuron
https://www.readbyqxmd.com/read/29274430/divergent-brain-changes-in-two-audiogenic-rat-strains-a-voxel-based-morphometry-and-diffusion-tensor-imaging-comparison-of-the-genetically-epilepsy-prone-rat-gepr-3-and-the-wistar-audiogenic-rat-war
#6
Yichien Lee, Olga C Rodriguez, Chris Albanese, Victor Rodrigues Santos, José Antônio Cortes de Oliveira, Ana Luiza Ferreira Donatti, Artur Fernandes, Norberto Garcia-Cairasco, Prosper N'Gouemo, Patrick A Forcelli
Acoustically evoked seizures (e.g., audiogenic seizures or AGS) are common in models of inherited epilepsy and occur in a variety of species including rat, mouse, and hamster. Two models that have been particularly well studied are the genetically epilepsy prone rat (GEPR-3) and the Wistar Audiogenic Rat (WAR) strains. Acute and repeated AGS, as well as comorbid conditions, displays a close phenotypic overlap in these models. Whether these similarities arise from convergent or divergent structural changes in the brain remains unknown...
December 20, 2017: Neurobiology of Disease
https://www.readbyqxmd.com/read/29249953/learning-peri-saccadic-remapping-of-receptive-field-from-experience-in-lateral-intraparietal-area
#7
Xiao Wang, Yan Wu, Mingsha Zhang, Si Wu
Our eyes move constantly at a frequency of 3-5 times per second. These movements, called saccades, induce the sweeping of visual images on the retina, yet we perceive the world as stable. It has been suggested that the brain achieves this visual stability via predictive remapping of neuronal receptive field (RF). A recent experimental study disclosed details of this remapping process in the lateral intraparietal area (LIP), that is, about the time of the saccade, the neuronal RF expands along the saccadic trajectory temporally, covering the current RF (CRF), the future RF (FRF), and the region the eye will sweep through during the saccade...
2017: Frontiers in Computational Neuroscience
https://www.readbyqxmd.com/read/29234300/temporal-discrimination-mechanisms-and-relevance-to-adult-onset-dystonia
#8
REVIEW
Antonella Conte, Eavan M McGovern, Shruti Narasimham, Rebecca Beck, Owen Killian, Sean O'Riordan, Richard B Reilly, Michael Hutchinson
Temporal discrimination is the ability to determine that two sequential sensory stimuli are separated in time. For any individual, the temporal discrimination threshold (TDT) is the minimum interval at which paired sequential stimuli are perceived as being asynchronous; this can be assessed, with high test-retest and inter-rater reliability, using a simple psychophysical test. Temporal discrimination is disordered in a number of basal ganglia diseases including adult-onset dystonia, of which the two most common phenotypes are cervical dystonia and blepharospasm...
2017: Frontiers in Neurology
https://www.readbyqxmd.com/read/29224981/visuomotor-mental-rotation-of-a-saccade-the-contingent-negative-variation-scales-to-the-angle-of-rotation
#9
Matthew Heath, Francisco L Colino, Jillian Chan, Olave E Krigolson
The visuomotor mental rotation (VMR) of a saccade requires a response to a region of space that is dissociated from a stimulus by a pre-specified angle, and work has shown a monotonic increase in reaction times as a function of increasing oblique angles of rotation. These results have been taken as evidence of a continuous process of rotation and have generated competing hypotheses. One hypothesis asserts that rotation is mediated via frontoparietal structures, whereas a second states that a continuous shift in the activity of direction-specific neurons in the superior colliculus (SC) supports rotation...
December 7, 2017: Vision Research
https://www.readbyqxmd.com/read/29218725/characterization-of-retinal-ganglion-cell-horizontal-cell-and-amacrine-cell-types-expressing-the-neurotrophic-receptor-tyrosine-kinase-ret
#10
Nadia Parmhans, Szilard Sajgo, Jingwen Niu, Wenqin Luo, Tudor Constantin Badea
We report the retinal expression pattern of Ret, a receptor tyrosine kinase for the Glial Derived Neurotrophic Factor (GDNF) family ligands (GFLs), during development and in the adult mouse. Ret is initially expressed in Retinal Ganglion Cells (RGCs), followed by Horizontal Cells (HCs) and Amacrine Cells (ACs), beginning with the early stages of postmitotic development. Ret expression persists in all three classes of neurons in the adult. Using RNA sequencing, immunostaining and random sparse recombination, we show that Ret is expressed in at least three distinct types of ACs, and ten types of RGCs...
December 8, 2017: Journal of Comparative Neurology
https://www.readbyqxmd.com/read/29209804/efferents-of-anterior-cingulate-areas-24a-and-24b-and-midcingulate-areas-24a-and-24b-in-the-mouse
#11
Clémentine Fillinger, Ipek Yalcin, Michel Barrot, Pierre Veinante
The anterior cingulate cortex (ACC), constituted by areas 25, 32, 24a and 24b in rodents, plays a major role in cognition, emotion and pain. In a previous study, we described the afferents of areas 24a and 24b and those of areas 24a' and 24b' of midcingulate cortex (MCC) in mice and highlighted some density differences among cingulate inputs (Fillinger et al., Brain Struct Funct 222:1509-1532, 2017). To complete this connectome, we analyzed here the efferents of ACC and MCC by injecting anterograde tracers in areas 24a/24b of ACC and 24a'/24b' of MCC...
December 6, 2017: Brain Structure & Function
https://www.readbyqxmd.com/read/29199075/nigrotectal-stimulation-stops-interval-timing-in-mice
#12
Koji Toda, Nicholas A Lusk, Glenn D R Watson, Namsoo Kim, Dongye Lu, Haofang E Li, Warren H Meck, Henry H Yin
Considerable evidence implicates the basal ganglia in interval timing, yet the underlying mechanisms remain poorly understood. Using a novel behavioral task, we demonstrate that head-fixed mice can be trained to show the key features of timing behavior within a few sessions. Single-trial analysis of licking behavior reveals stepping dynamics with variable onset times, which is responsible for the canonical Gaussian distribution of timing behavior. Moreover, the duration of licking bouts decreased as mice became sated, showing a strong motivational modulation of licking bout initiation and termination...
November 22, 2017: Current Biology: CB
https://www.readbyqxmd.com/read/29196716/disrupted-superior-collicular-activity-may-reveal-cervical-dystonia-disease-pathomechanisms
#13
Eavan M Mc Govern, Owen Killian, Shruti Narasimham, Brendan Quinlivan, John B Butler, Rebecca Beck, Ines Beiser, Laura W Williams, Ronan P Killeen, Michael Farrell, Sean O'Riordan, Richard B Reilly, Michael Hutchinson
Cervical dystonia is a common neurological movement disorder characterised by muscle contractions causing abnormal movements and postures affecting the head and neck. The neural networks underpinning this condition are incompletely understood. While animal models suggest a role for the superior colliculus in its pathophysiology, this link has yet to be established in humans. The present experiment was designed to test the hypothesis that disrupted superior collicular processing is evident in affected patients and in relatives harbouring a disease-specific endophenotype (abnormal temporal discrimination)...
December 1, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29180610/functional-organization-and-dynamic-activity-in-the-superior-colliculus-of-the-echolocating-bat-eptesicus-fuscus
#14
Melville J Wohlgemuth, Ninad B Kothari, Cynthia F Moss
Sensory-guided behaviors require the transformation of sensory information into task-specific motor commands. Prior research on sensorimotor integration has emphasized visuomotor processes in the context of simplified orienting movements in controlled laboratory tasks, rather than an animal's more complete, natural behavioral repertoire. Here, we conducted a series of neural recording experiments in the midbrain superior colliculus (SC) of echolocating bats engaged in a sonar target-tracking task that invoked dynamic active sensing behaviors...
November 27, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/29175956/the-mouse-pulvinar-nucleus-links-the-lateral-extrastriate-cortex-striatum-and-amygdala
#15
N Zhou, S P Masterson, J K Damron, W Guido, M E Bickford
The pulvinar nucleus is a large thalamic structure involved in the integration of visual and motor signals. The pulvinar forms extensive connections with striate and extrastriate cortical areas, but the impact of these connections on cortical circuits has not previously been directly tested. Using a variety of anatomical, optogenetic, and in vitro physiological techniques in male and female mice, we show that pulvinocortical terminals are densely distributed in the extrastriate cortex where they form synaptic connections with spines and small diameter dendrites...
November 23, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/29155351/erp-responses-greater-for-faces-in-the-temporal-compared-to-the-nasal-visual-field
#16
David Framorando, Nicolas Burra, Mylène Bapst, Alan J Pegna
The distribution of retino-tectal projections is dissimilar depending on whether the receptors are situated in the nasal and temporal visual hemiretinas. Indeed, it has been claimed that the superior colliculus receives a greater proportion of its input from the temporal visual hemifield (nasal hemi-retina) relative to the nasal hemifield (temporal hemi-retina). In order to investigate whether these subcortical projections influence face processing, we investigated the early cortical ERP responses to faces and houses presented in the temporal and nasal retinas using monocular viewing...
November 16, 2017: Neuroscience Letters
https://www.readbyqxmd.com/read/29154915/cocaine-and-amphetamine-regulated-transcript-peptide-and-calcium-binding-proteins-immunoreactivity-in-the-deep-layers-of-the-superior-colliculus-of-the-guinea-pig-implications-for-multisensory-and-visuomotor-processing
#17
Janusz Najdzion
The superior colliculus (SC) of mammals is a midbrain center, that can be subdivided into the superficial (SCs) and deep layers (SCd). In contrast to the visual SCs, the SCd are involved in multisensory and motor processing. This study investigated the pattern of distribution and colocalization of cocaine- and amphetamine-regulated transcript peptide (CART) and three calcium-binding proteins (CaBPs) i.e. calbindin (CB), calretinin (CR) and parvalbumin (PV) in the SCd of the guinea pig. CART labeling was seen almost exclusively in the neuropil and fibers, which differed in regard to morphology and location...
November 14, 2017: Journal of Chemical Neuroanatomy
https://www.readbyqxmd.com/read/29148158/long-term-anesthetic-protocol-in-rats-feasibility-in-electrophysiology-studies-in-visual-prosthesis
#18
Alejandro Barriga-Rivera, Veronica Tatarinoff, Nigel H Lovell, John W Morley, Gregg J Suaning
Electrical stimulation of excitable cells provides therapeutic benefits for a variety of medical conditions, including restoration of partial vision to those blinded via some types of retinal degeneration. To improve visual percepts elicited by the current technology, researchers are conducting acute electrophysiology experiments, mainly in cats. However, the rat can provide a model of a range of retinal diseases and possesses a sufficiently large eye to be used in this field. This article presents a long-term anesthetic protocol to enable electrophysiology experiments to further the development of visual prostheses...
November 17, 2017: Veterinary Ophthalmology
https://www.readbyqxmd.com/read/29134765/developmental-retinal-ganglion-cell-death-and-retinotopicity-of-the-murine-retinocollicular-projection
#19
Jamie Beros, Jennifer Rodger, Alan R Harvey
During mammalian visual system development, retinal ganglion cells (RGCs) undergo extensive apoptotic death. In mouse retina, approximately 50% of RGCs present at birth (postnatal day 0; P0) die by P5, at a time when axons innervate central targets such as the superior colliculus (SC). We examined whether RGCs that make short-range axonal targeting errors within the contralateral SC are more likely to be eliminated during the peak period of RGC death (P1-P5), compared with RGCs initially making more accurate retinotopic connections...
November 14, 2017: Developmental Neurobiology
https://www.readbyqxmd.com/read/29134717/superior-colliculus-resting-state-networks-in-post-traumatic-stress-disorder-and-its-dissociative-subtype
#20
Isadora Olivé, Maria Densmore, Sherain Harricharan, Jean Théberge, Margaret C McKinnon, Ruth Lanius
OBJECTIVES: The innate alarm system (IAS) models the neurocircuitry involved in threat processing in posttraumatic stress disorder (PTSD). Here, we investigate a primary subcortical structure of the IAS model, the superior colliculus (SC), where the SC is thought to contribute to the mechanisms underlying threat-detection in PTSD. Critically, the functional connectivity between the SC and other nodes of the IAS remains unexplored. EXPERIMENTAL DESIGN: We conducted a resting-state fMRI study to investigate the functional architecture of the IAS, focusing on connectivity of the SC in PTSD (n = 67), its dissociative subtype (n = 41), and healthy controls (n = 50) using region-of-interest seed-based analysis...
November 13, 2017: Human Brain Mapping
keyword
keyword
75827
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"