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JOURNAL ARTICLE
Emily Strouphauer, Carlos Valenzuela-Flores, Abu Minhajuddin, Holli Slater, David B Riddle, Caitlin M Pinciotti, Andrew G Guzick, John M Hettema, Silvina Tonarelli, Cesar A Soutullo, Joshua S Elmore, Kimberly Gushanas, Sarah Wakefield, Wayne K Goodman, Madhukar H Trivedi, Eric A Storch, Matti Cervin
BACKGROUND: Major depressive disorder (MDD) is common in youth and among the most frequent comorbid disorders in pediatric obsessive-compulsive disorder (OCD), but it is unclear whether the presence of OCD affects the symptom presentation of MDD in youth. METHODS: A sample of youth with OCD and MDD (n = 124) and a sample of youth with MDD but no OCD (n = 673) completed the Patient Health Questionnaire for Adolescents (PHQ-A). The overall and symptom-level presentation of MDD were examined using group comparisons and network analysis...
January 8, 2024: Journal of Affective Disorders
#2
Fares Bassil, Hannah J Brown, Shankar Pattabhiraman, Joe E Iwasyk, Chantal M Maghames, Emily S Meymand, Timothy O Cox, Dawn M Riddle, Bin Zhang, John Q Trojanowski, Virginia M-Y Lee
No abstract text is available yet for this article.
November 15, 2023: Neuron
#3
JOURNAL ARTICLE
Alexandra Touroutoglou, Yuta Katsumi, Michael Brickhouse, Alexander Zaitsev, Ryan Eckbo, Paul Aisen, Laurel Beckett, Jeffrey L Dage, Ani Eloyan, Tatiana Foroud, Bernardino Ghetti, Percy Griffin, Dustin Hammers, Clifford R Jack, Joel H Kramer, Leonardo Iaccarino, Renaud La Joie, Nidhi S Mundada, Robert Koeppe, Walter A Kukull, Melissa E Murray, Kelly Nudelman, Angelina J Polsinelli, Malia Rumbaugh, David N Soleimani-Meigooni, Arthur Toga, Prashanthi Vemuri, Alireza Atri, Gregory S Day, Ranjan Duara, Neill R Graff-Radford, Lawrence S Honig, David T Jones, Joseph C Masdeu, Mario F Mendez, Erik Musiek, Chiadi U Onyike, Meghan Riddle, Emily Rogalski, Stephen Salloway, Sharon Sha, R Scott Turner, Thomas S Wingo, David A Wolk, Kyle Womack, Maria C Carrillo, Gil D Rabinovici, Liana G Apostolova, Bradford C Dickerson
INTRODUCTION: Magnetic resonance imaging (MRI) research has advanced our understanding of neurodegeneration in sporadic early-onset Alzheimer's disease (EOAD) but studies include small samples, mostly amnestic EOAD, and have not focused on developing an MRI biomarker. METHODS: We analyzed MRI scans to define the sporadic EOAD-signature atrophy in a small sample (n = 25) of Massachusetts General Hospital (MGH) EOAD patients, investigated its reproducibility in the large longitudinal early-onset Alzheimer's disease study (LEADS) sample (n = 211), and investigated the relationship of the magnitude of atrophy with cognitive impairment...
October 18, 2023: Alzheimer's & Dementia: the Journal of the Alzheimer's Association
#4
REVIEW
Kelly N H Nudelman, Trever Jackson, Malia Rumbaugh, Ani Eloyan, Marco Abreu, Jeffrey L Dage, Casey Snoddy, Kelley M Faber, Tatiana Foroud, Dustin B Hammers, Alexander Taurone, Maryanne Thangarajah, Paul Aisen, Laurel Beckett, Joel Kramer, Robert Koeppe, Walter A Kukull, Melissa E Murray, Arthur W Toga, Prashanthi Vemuri, Alireza Atri, Gregory S Day, Ranjan Duara, Neill R Graff-Radford, Lawrence S Honig, David T Jones, Joseph C Masdeu, Mario Mendez, Erik Musiek, Chiadi U Onyike, Meghan Riddle, Emily Rogalski, Stephen Salloway, Sharon J Sha, R Scott Turner, Thomas S Wingo, David A Wolk, Maria C Carrillo, Bradford C Dickerson, Gil D Rabinovici, Liana G Apostolova
INTRODUCTION: One goal of the Longitudinal Early-onset Alzheimer's Disease Study (LEADS) is to investigate the genetic etiology of early onset (40-64 years) cognitive impairment. Toward this goal, LEADS participants are screened for known pathogenic variants. METHODS: LEADS amyloid-positive early-onset Alzheimer's disease (EOAD) or negative early-onset non-AD (EOnonAD) cases were whole exome sequenced (N = 299). Pathogenic variant frequency in APP, PSEN1, PSEN2, GRN, MAPT, and C9ORF72 was assessed for EOAD and EOnonAD...
October 6, 2023: Alzheimer's & Dementia: the Journal of the Alzheimer's Association
#5
JOURNAL ARTICLE
Hanna Cho, Nidhi S Mundada, Liana G Apostolova, Maria C Carrillo, Ranjani Shankar, Alinda N Amuiri, Ehud Zeltzer, Charles C Windon, David N Soleimani-Meigooni, Jeremy A Tanner, Courtney Lawhn Heath, Orit H Lesman-Segev, Paul Aisen, Ani Eloyan, Hye Sun Lee, Dustin B Hammers, Kala Kirby, Jeffrey L Dage, Anne Fagan, Tatiana Foroud, Lea T Grinberg, Clifford R Jack, Joel Kramer, Walter A Kukull, Melissa E Murray, Kelly Nudelman, Arthur Toga, Prashanthi Vemuri, Alireza Atri, Gregory S Day, Ranjan Duara, Neill R Graff-Radford, Lawrence S Honig, David T Jones, Joseph Masdeu, Mario Mendez, Erik Musiek, Chiadi U Onyike, Meghan Riddle, Emily J Rogalski, Stephen Salloway, Sharon Sha, Raymond Scott Turner, Thomas S Wingo, David A Wolk, Robert Koeppe, Leonardo Iaccarino, Bradford C Dickerson, Renaud La Joie, Gil D Rabinovici
INTRODUCTION: We aimed to describe baseline amyloid-beta (Aβ) and tau-positron emission tomograrphy (PET) from Longitudinal Early-onset Alzheimer's Disease Study (LEADS), a prospective multi-site observational study of sporadic early-onset Alzheimer's disease (EOAD). METHODS: We analyzed baseline [18F]Florbetaben (Aβ) and [18F]Flortaucipir (tau)-PET from cognitively impaired participants with a clinical diagnosis of mild cognitive impairment (MCI) or AD dementia aged < 65 years...
September 10, 2023: Alzheimer's & Dementia: the Journal of the Alzheimer's Association
#6
JOURNAL ARTICLE
Justin Bushnell, Dustin B Hammers, Paul Aisen, Jeffrey L Dage, Ani Eloyan, Tatiana Foroud, Lea T Grinberg, Leonardo Iaccarino, Clifford R Jack, Kala Kirby, Joel Kramer, Robert Koeppe, Walter A Kukull, Renaud La Joie, Nidhi S Mundada, Melissa E Murray, Kelly Nudelman, Malia Rumbaugh, David N Soleimani-Meigooni, Arthur Toga, Alexandra Touroutoglou, Prashanthi Vemuri, Alireza Atri, Gregory S Day, Ranjan Duara, Neill R Graff-Radford, Lawrence S Honig, David T Jones, Joseph Masdeu, Mario Mendez, Erik Musiek, Chiadi U Onyike, Meghan Riddle, Emily Rogalski, Steven Salloway, Sharon Sha, Raymond S Turner, Thomas S Wingo, David A Wolk, Maria C Carrillo, Bradford C Dickerson, Gil D Rabinovici, Liana G Apostolova, David G Clark
INTRODUCTION: The Rey Auditory Verbal Learning Test (RAVLT) is a useful neuropsychological test for describing episodic memory impairment in dementia. However, there is limited research on its utility in early-onset Alzheimer's disease (EOAD). We assess the influence of amyloid and diagnostic syndrome on several memory scores in EOAD. METHODS: We transcribed RAVLT recordings from 303 subjects in the Longitudinal Early-Onset Alzheimer's Disease Study. Subjects were grouped by amyloid status and syndrome...
August 31, 2023: Alzheimer's & Dementia: the Journal of the Alzheimer's Association
#7
JOURNAL ARTICLE
Sára Nemes, Paige E Logan, Mohit K Manchella, Nidhi S Mundada, Renaud La Joie, Angelina J Polsinelli, Dustin B Hammers, Robert A Koeppe, Tatiana M Foroud, Kelly N Nudelman, Ani Eloyan, Leonardo Iaccarino, Valérie Dorsant-Ardón, Alexander Taurone, Maryanne Thangarajah, Jeffery L Dage, Paul Aisen, Lea T Grinberg, Clifford R Jack, Joel Kramer, Walter A Kukull, Melissa E Murray, Malia Rumbaugh, David N Soleimani-Meigooni, Arthur Toga, Alexandra Touroutoglou, Prashanthi Vemuri, Alireza Atri, Gregory S Day, Ranjan Duara, Neill R Graff-Radford, Lawrence S Honig, David T Jones, Joseph Masdeu, Mario F Mendez, Erik Musiek, Chiadi U Onyike, Meghan Riddle, Emily Rogalski, Stephen Salloway, Sharon J Sha, Raymond S Turner, Thomas S Wingo, Kyle B Womack, David A Wolk, Gil D Rabinovici, Maria C Carrillo, Bradford C Dickerson, Liana G Apostolova
INTRODUCTION: We used sex and apolipoprotein E ε4 (APOE ε4) carrier status as predictors of pathologic burden in early-onset Alzheimer's disease (EOAD). METHODS: We included baseline data from 77 cognitively normal (CN), 230 EOAD, and 70 EO non-Alzheimer's disease (EOnonAD) participants from the Longitudinal Early-Onset Alzheimer's Disease Study (LEADS). We stratified each diagnostic group by males and females, then further subdivided each sex by APOE ε4 carrier status and compared imaging biomarkers in each stratification...
July 26, 2023: Alzheimer's & Dementia: the Journal of the Alzheimer's Association
#8
JOURNAL ARTICLE
Jeffrey L Dage, Ani Eloyan, Maryanne Thangarajah, Dustin B Hammers, Anne M Fagan, Julia D Gray, Suzanne E Schindler, Casey Snoddy, Kelly N H Nudelman, Kelley M Faber, Tatiana Foroud, Paul Aisen, Percy Griffin, Lea T Grinberg, Leonardo Iaccarino, Kala Kirby, Joel Kramer, Robert Koeppe, Walter A Kukull, Renaud La Joie, Nidhi S Mundada, Melissa E Murray, Malia Rumbaugh, David N Soleimani-Meigooni, Arthur W Toga, Alexandra Touroutoglou, Prashanthi Vemuri, Alireza Atri, Laurel A Beckett, Gregory S Day, Neill R Graff-Radford, Ranjan Duara, Lawrence S Honig, David T Jones, Joseph C Masdeu, Mario F Mendez, Erik Musiek, Chiadi U Onyike, Meghan Riddle, Emily Rogalski, Stephen Salloway, Sharon J Sha, Raymond S Turner, Thomas S Wingo, David A Wolk, Kyle B Womack, Maria C Carrillo, Bradford C Dickerson, Gil D Rabinovici, Liana G Apostolova
INTRODUCTION: One goal of the Longitudinal Early Onset Alzheimer's Disease Study (LEADS) is to define the fluid biomarker characteristics of early-onset Alzheimer's disease (EOAD). METHODS: Cerebrospinal fluid (CSF) concentrations of Aβ1-40, Aβ1-42, total tau (tTau), pTau181, VILIP-1, SNAP-25, neurogranin (Ng), neurofilament light chain (NfL), and YKL-40 were measured by immunoassay in 165 LEADS participants. The associations of biomarker concentrations with diagnostic group and standard cognitive tests were evaluated...
July 25, 2023: Alzheimer's & Dementia: the Journal of the Alzheimer's Association
#9
JOURNAL ARTICLE
Devyn R Riddle, Emily K Presseller, Adrienne S Juarascio
OBJECTIVE: Emotion dysregulation (i.e., a multi-component term comprising nonacceptance of emotional responses, difficulty engaging in goal-directed behaviour, impulse control difficulties, lack of emotional awareness, limited access to emotion regulation strategies, and lack of emotional clarity) is a well-established transdiagnostic risk and maintenance factor for eating disorders. To date, there is limited information on how varying scores on subdomains of emotion dysregulation may yield distinct profiles in individuals with binge-spectrum eating disorders (B-EDs), and how these emotion dysregulation profiles may inform resultant symptomatology...
July 3, 2023: European Eating Disorders Review: the Journal of the Eating Disorders Association
#10
JOURNAL ARTICLE
Katherine Adams, John J Riddles, Elizabeth A K Rowley, Shaun J Grannis, Manjusha Gaglani, Bruce Fireman, Emily Hartmann, Allison L Naleway, Edward Stenehjem, Alexandria Hughes, Alexandra F Dalton, Karthik Natarajan, Kristin Dascomb, Chandni Raiyani, Stephanie A Irving, Chantel Sloan-Aagard, Anupam B Kharbanda, Malini B DeSilva, Brian E Dixon, Toan C Ong, Jean Keller, Monica Dickerson, Nancy Grisel, Kempapura Murthy, Juan Nanez, William F Fadel, Sarah W Ball, Palak Patel, Julie Arndorfer, Mufaddal Mamawala, Nimish R Valvi, Margaret M Dunne, Eric P Griggs, Peter J Embi, Mark G Thompson, Ruth Link-Gelles, Mark W Tenforde
BACKGROUND: Understanding the usefulness of additional COVID-19 vaccine doses-particularly given varying disease incidence-is needed to support public health policy. We characterize the benefits of COVID-19 booster doses using number needed to vaccinate (NNV) to prevent one COVID-19-associated hospitalization or emergency department encounter. METHODS: We conducted a retrospective cohort study of immunocompetent adults at five health systems in four U.S. states during SARS-CoV-2 Omicron BA...
July 2023: Lancet Reg Health Am
#11
JOURNAL ARTICLE
Angelina J Polsinelli, Ryan J Wonderlin, Dustin B Hammers, Alex Pena Garcia, Ani Eloyan, Alexander Taurone, Maryanne Thangarajah, Laurel Beckett, Sujuan Gao, Sophia Wang, Kala Kirby, Paige E Logan, Paul Aisen, Jeffrey L Dage, Tatiana Foroud, Percy Griffin, Leonardo Iaccarino, Joel H Kramer, Robert Koeppe, Walter A Kukull, Renaud La Joie, Nidhi S Mundada, Melissa E Murray, Kelly Nudelman, David N Soleimani-Meigooni, Malia Rumbaugh, Arthur W Toga, Alexandra Touroutoglou, Prashanthi Vemuri, Alireza Atri, Gregory S Day, Ranjan Duara, Neill R Graff-Radford, Lawrence S Honig, David T Jones, Joseph Masdeu, Mario F Mendez, Kyle Womack, Erik Musiek, Chiadi U Onyike, Meghan Riddle, Emily Rogalski, Steven Salloway, Sharon J Sha, Raymond S Turner, Thomas S Wingo, David A Wolk, Maria C Carrillo, Bradford C Dickerson, Gil D Rabinovici, Liana G Apostolova
INTRODUCTION: We examined neuropsychiatric symptoms (NPS) and psychotropic medication use in a large sample of individuals with early-onset Alzheimer's disease (EOAD; onset 40-64 years) at the midway point of data collection for the Longitudinal Early-onset Alzheimer's Disease Study (LEADS). METHODS: Baseline NPS (Neuropsychiatric Inventory - Questionnaire; Geriatric Depression Scale) and psychotropic medication use from 282 participants enrolled in LEADS were compared across diagnostic groups - amyloid-positive EOAD (n = 212) and amyloid negative early-onset non-Alzheimer's disease (EOnonAD; n = 70)...
June 9, 2023: Alzheimer's & Dementia: the Journal of the Alzheimer's Association
#12
JOURNAL ARTICLE
Dustin B Hammers, Ani Eloyan, Alexander Taurone, Maryanne Thangarajah, Laurel Beckett, Sujuan Gao, Kala Kirby, Paul Aisen, Jeffrey L Dage, Tatiana Foroud, Percy Griffin, Lea T Grinberg, Clifford R Jack, Joel Kramer, Robert Koeppe, Walter A Kukull, Nidhi S Mundada, Renaud La Joie, David N Soleimani-Meigooni, Leonardo Iaccarino, Melissa E Murray, Kelly Nudelman, Angelina J Polsinelli, Malia Rumbaugh, Arthur Toga, Alexandra Touroutoglou, Prashanthi Vemuri, Alireza Atri, Gregory S Day, Ranjan Duara, Neill R Graff-Radford, Lawrence S Honig, David T Jones, Joseph Masdeu, Mario F Mendez, Kyle Womack, Erik Musiek, Chiadi U Onyike, Meghan Riddle, Emily Rogalski, Steven Salloway, Sharon J Sha, Raymond Scott Turner, Thomas S Wingo, David A Wolk, Maria C Carrillo, Bradford C Dickerson, Gil D Rabinovici, Liana G Apostolova
OBJECTIVE: The Longitudinal Early-Onset Alzheimer's Disease Study (LEADS) seeks to provide comprehensive understanding of early-onset Alzheimer's disease (EOAD; onset <65 years), with the current study profiling baseline clinical, cognitive, biomarker, and genetic characteristics of the cohort nearing the data-collection mid-point. METHODS: Data from 371 LEADS participants were compared based on diagnostic group classification (cognitively normal [n = 89], amyloid-positive EOAD [n = 212], and amyloid-negative early-onset non-Alzheimer's disease [EOnonAD; n = 70])...
May 31, 2023: Alzheimer's & Dementia: the Journal of the Alzheimer's Association
#13
JOURNAL ARTICLE
Dustin B Hammers, Sára Nemes, Taylor Diedrich, Ani Eloyan, Kala Kirby, Paul Aisen, Joel Kramer, Kelly Nudelman, Tatiana Foroud, Malia Rumbaugh, Alireza Atri, Gregory S Day, Ranjan Duara, Neill R Graff-Radford, Lawrence S Honig, David T Jones, Joseph C Masdeu, Mario F Mendez, Erik Musiek, Chiadi U Onyike, Meghan Riddle, Emily Rogalski, Steve Salloway, Sharon J Sha, Raymond Scott Turner, Sandra Weintraub, Thomas S Wingo, David A Wolk, Bonnie Wong, Maria C Carrillo, Bradford C Dickerson, Gil D Rabinovici, Liana G Apostolova
OBJECTIVE: Investigation of learning slopes in early-onset dementias has been limited. The current study aimed to highlight the sensitivity of learning slopes to discriminate disease severity in cognitively normal participants and those diagnosed with early-onset dementia with and without β-amyloid positivity METHOD: Data from 310 participants in the Longitudinal Early-Onset Alzheimer's Disease Study (aged 41 to 65) were used to calculate learning slope metrics. Learning slopes among diagnostic groups were compared, and the relationships of slopes with standard memory measures were determined RESULTS: Worse learning slopes were associated with more severe disease states, even after controlling for demographics, total learning, and cognitive severity...
May 27, 2023: Alzheimer's & Dementia: the Journal of the Alzheimer's Association
#14
JOURNAL ARTICLE
Catherine H Bozio, Kristen A Butterfield, Melissa Briggs Hagen, Shaun Grannis, Paul Drawz, Emily Hartmann, Toan C Ong, Bruce Fireman, Karthik Natarajan, Kristin Dascomb, Manjusha Gaglani, Malini B DeSilva, Duck-Hye Yang, Claire M Midgley, Brian E Dixon, Allison L Naleway, Nancy Grisel, I-Chia Liao, Sarah E Reese, William F Fadel, Stephanie A Irving, Ned Lewis, Julie Arndorfer, Kempapura Murthy, John Riddles, Nimish R Valvi, Mufaddal Mamawala, Peter J Embi, Mark G Thompson, Edward Stenehjem
BACKGROUND: Data assessing protection conferred from COVID-19 mRNA vaccination and/or prior SARS-CoV-2 infection during Delta and Omicron predominance periods in the U.S. are limited. METHODS: This cohort study included persons ≥18 years who had ≥1 healthcare encounter across four health systems and had been tested for SARS-CoV-2 before August 26, 2021. COVID-19 mRNA vaccination and prior SARS-CoV-2 infection defined the exposure. Cox regression estimated hazard ratios (HRs) for the Delta and Omicron periods; protection was calculated as (1-HR)x100%...
February 18, 2023: Journal of Infectious Diseases
#15
JOURNAL ARTICLE
Jennifer L Bueche, Jennifer M K Jensen, Kelly Martin, Emily Riddle, Kim S Stote
The COVID-19 pandemic necessitated the use of distance education, which sparked a technological transformation that was long overdue in higher education. The purpose of this narrative review is two-fold: 1) to summarize the state of knowledge regarding distance education in nutrition and dietetics education over the last 30 years to inform recommendations for future education/research and implications for practice and 2) to determine the impact that distance education has had on the knowledge, skills, and attitudes of both nutrition and dietetic educators and their students...
November 15, 2022: Journal of the Academy of Nutrition and Dietetics
#16
JOURNAL ARTICLE
Garrett S Gibbons, Soo-Jung Kim, Qihui Wu, Dawn M Riddle, Susan N Leight, Lakshmi Changolkar, Hong Xu, Emily S Meymand, Mia O'Reilly, Bin Zhang, Kurt R Brunden, John Q Trojanowski, Virginia M Y Lee
BACKGROUND: The spread of tau pathology in Alzheimer's disease (AD) is mediated by cell-to-cell transmission of pathological tau seeds released from neurons that, upon internalization by recipient neurons, template the misfolding of naïve cellular tau, thereby propagating fibrillization. We hypothesize that anti-tau monoclonal antibodies (mAbs) that selectively bind to pathological tau seeds will inhibit propagation of tau aggregates and reduce the spread of tau pathology in vivo. METHODS: We inoculated mice with human AD brain-derived extracts containing tau paired helical filaments (AD-tau) and identified two novel mAbs, DMR7 and SKT82, that selectively bind to a misfolded pathological conformation of tau relative to recombinant tau monomer...
November 4, 2020: Molecular Neurodegeneration
#17
JOURNAL ARTICLE
Emilie S Riddle, Meredith T Niles, Amy Nickerson
Comprehensive assessment of food insecurity across all college community members is lacking. This research surveyed a random sample of an entire campus population at a Northeast University in two surveys (spring 2017, n = 1,037 and fall 2017, n = 1,123). Analysis of variance, t-tests, and multivariable logit models were used to understand food insecurity outcomes and comparisons among groups. The overall rate of food insecurity on campus was 19.6% (spring) and 15.0% (fall). Food insecurity rates were highest among undergraduates, graduate and medical students, and staff as compared to faculty...
2020: PloS One
#18
JOURNAL ARTICLE
Daniel W Youngstrom, Robert L Zondervan, Nicole R Doucet, Parker K Acevedo, Hannah E Sexton, Emily A Gardner, JonCarlos S Anderson, Priyanka Kushwaha, Hannah C Little, Susana Rodriguez, Ryan C Riddle, Ivo Kalajzic, G William Wong, Kurt D Hankenson
C1q/TNF-related protein 3 (CTRP3) is a cytokine known to regulate a variety of metabolic processes. Though previously undescribed in the context of bone regeneration, high throughput gene expression experiments in mice identified CTRP3 as one of the most highly upregulated genes in fracture callus tissue. Hypothesizing a positive regulatory role for CTRP3 in bone regeneration, we phenotyped skeletal development and fracture healing in CTRP3 knockout (KO) and CTRP3 overexpressing transgenic (TG) mice relative to wild-type (WT) control animals...
December 6, 2019: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
#19
JOURNAL ARTICLE
Fares Bassil, Hannah J Brown, Shankar Pattabhiraman, Joe E Iwasyk, Chantal M Maghames, Emily S Meymand, Timothy O Cox, Dawn M Riddle, Bin Zhang, John Q Trojanowski, Virginia M-Y Lee
Studies have shown an overlap of Aβ plaques, tau tangles, and α-synuclein (α-syn) pathologies in the brains of Alzheimer's disease (AD) and Parkinson's disease (PD) with dementia (PDD) patients, with increased pathological burden correlating with severity of cognitive and motor symptoms. Despite the observed co-pathology and concomitance of motor and cognitive phenotypes, the consequences of the primary amyloidogenic protein on the secondary pathologies remain poorly understood. To better define the relationship between α-syn and Aβ plaques, we injected α-syn preformed fibrils (α-syn mpffs) into mice with abundant Aβ plaques...
January 22, 2020: Neuron
#20
JOURNAL ARTICLE
Emily S Riddle, Erica L Bender, Anna E Thalacker-Mercer
Activation of satellite cells and expansion of the muscle progenitor cell (MPC) population is essential to generate a sufficient number of cells to repair damaged skeletal muscle. Proliferating MPCs have high energetic and biosynthetic material requirements, and the ability to utilize oxidative phosphorylation (OXPHOS) and/or glycolysis may affect expansion capacity of MPCs. In the present study, we investigated whether donor age and sex impact human MPC (hMPCs) expansion capacity and metabolic fuel preference...
August 15, 2018: American Journal of Physiology. Cell Physiology
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