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Apo E4

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https://www.readbyqxmd.com/read/27895004/predictors-of-vascular-cognitive-impairment-poststroke-in-a-middle-eastern-bahrain-cohort-a-proposed-case-control-comparison
#1
Claire Donnellan, Mona Al Banna, Noor Redha, Adel Al Jishi, Isa Al Sharoqi, Safa Taha, Moiz Bakhiet, Fatema Abdulla, Patrick Walsh
BACKGROUND: Poststroke dementia and cognitive impairment are associated with poor long-term outcomes after stroke. The contribution of genetic factors such as the presence of apolipoprotein (ApoE) ɛ4 allele and its association with cognitive impairment poststroke remains inconclusive, particularly in Middle Eastern regions. OBJECTIVE: The aim of this study is to examine all correlates and potential predictors of cognitive impairment including self-awareness and regulation deficits in stroke patients and compare these functions with healthy older adults from a Middle Eastern population...
November 28, 2016: JMIR Research Protocols
https://www.readbyqxmd.com/read/27891223/is-apoe-%C3%A9-4-a-good-biomarker-for-amyloid-pathology-in-late-onset-alzheimer-s-disease
#2
REVIEW
Maowen Ba, Min Kong, Xiaofeng Li, Kok Pin Ng, Pedro Rosa-Neto, Serge Gauthier
Amyloid plaques are pathological hallmarks of Alzheimer's Disease (AD) and biomarkers such as cerebrospinal fluid (CSF) β-amyloid 1-42 (Aβ1-42) and amyloid positron emission tomographic (PET) imaging are important in diagnosing amyloid pathology in vivo. ɛ4 allele of the Apolipoprotein E gene (ApoE ɛ 4), which is a major genetic risk factor for late onset AD, is an important genetic biomarker for AD pathophysiology. It has been shown that ApoE ɛ 4 is involved in Aβ deposition and formation of amyloid plaques...
2016: Translational Neurodegeneration
https://www.readbyqxmd.com/read/27868062/apolipoprotein-e-gene-variants-and-risk-of-coronary-heart-disease-a-meta-analysis
#3
REVIEW
Min Xu, Jun Zhao, Yu Zhang, Xu Ma, Qiaoyun Dai, Hong Zhi, Bei Wang, Lina Wang
Objectives. Apo E genes involved in lipoprotein synthesis and metabolism are considered one of the candidates to CHD. However, the results remain conflicting. Methods. We performed this meta-analysis based on 30 published studies including 11,804 CHD patients and 17,713 controls. Results. Compared with the wild genotype E3/3, the variant genotypes ApoEE3/4 and E4/4 were associated with 22% and 45% increased risk of CHD, respectively (E3/4 versus E3/3: OR = 1.22, 95% CI = 1.15-1.29; E4/4 versus E3/3: OR = 1...
2016: BioMed Research International
https://www.readbyqxmd.com/read/27849641/genetic-comparison-of-symptomatic-and-asymptomatic-persons-with-alzheimer-disease-neuropathology
#4
Sarah E Monsell, Charles Mock, David W Fardo, Sarah Bertelsen, Nigel J Cairns, Catherine M Roe, Sally R Ellingson, John C Morris, Alison M Goate, Walter A Kukull
OBJECTIVE: The objective was to determine whether symptomatic and asymptomatic persons with Alzheimer's disease (AD) neuropathology have different allele counts for single-nucleotide polymorphisms that have been associated with clinical late-onset AD. METHODS: Data came from the National Alzheimer's Coordinating Center Uniform Data Set and Neuropathology Data Set, and the Alzheimer's Disease Genetics Consortium (ADGC). Participants had low to high AD neuropathologic change...
November 15, 2016: Alzheimer Disease and Associated Disorders
https://www.readbyqxmd.com/read/27834774/five-year-longitudinal-brain-volume-change-in-healthy-elders-at-genetic-risk%C3%A2-for%C3%A2-alzheimer-s%C3%A2-disease
#5
Katherine Reiter, Kristy A Nielson, Sally Durgerian, John L Woodard, J Carson Smith, Michael Seidenberg, Dana A Kelly, Stephen M Rao
Neuropathological changes associated with Alzheimer's disease (AD) precede symptom onset by more than a decade. Possession of an apolipoprotein E (APOE) ɛ4 allele is the strongest genetic risk factor for late onset AD. Cross-sectional studies of cognitively intact elders have noted smaller hippocampal/medial temporal volumes in ɛ4 carriers (ɛ4+) compared to ɛ4 non-carriers (ɛ4-). Few studies, however, have examined long-term, longitudinal, anatomical brain changes comparing healthy ɛ4+ and ɛ4- individuals...
November 6, 2016: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/27824936/differential-effects-of-apoe4-and-activation-of-abca1-on-brain-and-plasma-lipoproteins
#6
Anat Boehm-Cagan, Roni Bar, Dror Harats, Aviv Shaish, Hana Levkovitz, John K Bielicki, Jan O Johansson, Daniel M Michaelson
Apolipoprotein E4 (apoE4), the leading genetic risk factor for Alzheimer's disease (AD), is less lipidated compared to the most common and AD-benign allele, apoE3. We have recently shown that i.p. injections of the ATP-binding cassette A1 (ABCA1) agonist peptide CS-6253 to apoE mice reverse the hypolipidation of apoE4 and the associated brain pathology and behavioral deficits. While in the brain apoE is the main cholesterol transporter, in the periphery apoE and apoA-I both serve as the major cholesterol transporters...
2016: PloS One
https://www.readbyqxmd.com/read/27823753/alzheimer-s-disease-apolipoprotein-e-and-hormone-replacement-therapy
#7
REVIEW
H Depypere, A Vierin, S Weyers, A Sieben
Alzheimer's disease is the most frequent cause of dementia in older patients. The prevalence is higher in women than in men. This may be the result of both the higher life expectancy of women and the loss of neuroprotective estrogen after menopause. Earlier age at menopause (spontaneous or surgical) is associated with an enhanced risk of developing Alzheimer's disease. Therefore, it is postulated that estrogen could be protective against it. If so, increasing exposure to estrogen through the use of postmenopausal hormone replacement could also be protective against Alzheimer's disease...
December 2016: Maturitas
https://www.readbyqxmd.com/read/27806189/effect-of-the-interplay-between-genetic-and-behavioral-risks-on-survival-after-age-75
#8
Debora Rizzuto, Lina Keller, Nicola Orsini, Caroline Graff, Lars Bäckman, Rino Bellocco, Hui-Xin Wang, Laura Fratiglioni
OBJECTIVES: To explore the association between genes that may be related to human mortality, taking into account the possible contribution of morbidity, and investigate whether lifestyle behaviors may attenuate genetic risk. DESIGN: Twenty-five-year population-based cohort study. SETTING: Kungsholmen cohort, Stockholm, Sweden. PARTICIPANTS: Individuals aged 75 and older (N = 1,229). MEASUREMENTS: The associations between single-nucleotide variations in 14 genes (previously associated with mortality or to diseases linked to mortality), relevant lifestyle risk behaviors (smoking; mental, physical, or social inactivity; moderate or poor social network), and mortality were estimated using Cox regression...
November 2, 2016: Journal of the American Geriatrics Society
https://www.readbyqxmd.com/read/27805724/moderating-risk-of-alzheimer-s-disease-through-the-use-of-anxiolytic-agents
#9
Shanna L Burke, Janice O'Driscoll, Amary Alcide, Tan Li
OBJECTIVES: Anxiety diagnoses occur in 17.1% in people age 65 years and older. Individuals with anxiety may be at a higher risk of the development of probable Alzheimer's disease (AD). Previous literature has suggested that anxiolytic medications may exacerbate the risk of AD development. This study explored anxiolytic medication as a potential moderator of AD risk in older adults. METHODS: A secondary data analysis of the National Alzheimer's Coordinating Center Uniform Data Set was undertaken, analyzing observations from 12,083 participants with normal cognition at the first visit...
November 2, 2016: International Journal of Geriatric Psychiatry
https://www.readbyqxmd.com/read/27805002/performance-metrics-for-selecting-single-nucleotide-polymorphisms-in-late-onset-alzheimer-s-disease
#10
Yen-Ching Chen, Chi-Jung Hsiao, Chien-Cheng Jung, Hui-Han Hu, Jen-Hau Chen, Wen-Chung Lee, Jeng-Min Chiou, Ta-Fu Chen, Yu Sun, Li-Li Wen, Ping-Keung Yip, Yi-Min Chu, Chien-Jen Chen, Hwai-I Yang
Previous genome-wide association studies using P-values to select single nucleotide polymorphisms (SNPs) have suffered from high false-positive and false-negative results. This case-control study recruited 713 late-onset Alzheimer's disease (LOAD) cases and controls aged ≥65 from three teaching hospitals in northern Taiwan from 2007 to 2010. Performance metrics were used to select SNPs in stage 1, which were then genotyped to another dataset (stage 2). Four SNPs (CPXM2 rs2362967, APOC1 rs4420638, ZNF521 rs7230380, and rs12965520) were identified for LOAD by both traditional P-values (without correcting for multiple tests) and performance metrics...
November 2, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27801937/self-reported-sleep-apnea-and-dementia-risk-findings-from-the-prevention-of-alzheimer-s-disease-with-vitamin-e-and-selenium-trial
#11
Xiuhua Ding, Richard J Kryscio, Joshua Turner, Gregory A Jicha, Gregory Cooper, Allison Caban-Holt, Frederick A Schmitt, Erin L Abner
OBJECTIVES: To investigate the association between baseline sleep apnea and risk of incident dementia in the Prevention of Alzheimer's Disease with Vitamin E and Selenium (PREADViSE) study and to explore whether the association depends on apolipoprotein E (APOE) ɛ4 allele status. DESIGN: Secondary analysis based on data collected during PREADViSE. SETTING: Participants were assessed at 128 local clinical study sites during the clinical trial phase and later were followed by telephone from a centralized location...
November 1, 2016: Journal of the American Geriatrics Society
https://www.readbyqxmd.com/read/27748454/colocalization-of-cerebral-iron-with-amyloid-beta-in-mild-cognitive-impairment
#12
J M G van Bergen, X Li, J Hua, S J Schreiner, S C Steininger, F C Quevenco, M Wyss, A F Gietl, V Treyer, S E Leh, F Buck, R M Nitsch, K P Pruessmann, P C M van Zijl, C Hock, P G Unschuld
Quantitative Susceptibility Mapping (QSM) MRI at 7 Tesla and 11-Carbon Pittsburgh-Compound-B PET were used for investigating the relationship between brain iron and Amyloid beta (Aβ) plaque-load in a context of increased risk for Alzheimer's disease (AD), as reflected by the Apolipoprotein E ε4 (APOE-e4) allele and mild cognitive impairment (MCI) in elderly subjects. Carriers of APOE-e4 with normal cognition had higher cortical Aβ-plaque-load than non-carriers. In MCI an association between APOE-e4 and higher Aβ-plaque-load was observable both for cortical and subcortical brain-regions...
October 17, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27717947/-predictive-value-of-apolipoproteine-e-genotypes
#13
Joanna Martenka, Krystyna Soszyńska
Apolipoprotein E is a transport protein, which by binding to lipids forms a lipoprotein particle. It is responsible for transport and redistribution of lipids between cells and tissues. Apolipoprotein E circulates in blood mainly as a component of VLDL (very low density lipoproteins) HDL (high density lipoproteins) chylomicrons and chylomicron remnants. It assists in the flow of cholesterol from peripheral cells to extracellular space. Apolipoprotein E is one of the most studied apolipoproteins. There are three isoforms of this protein: E2, E3 and E4...
2016: Wiadomości Lekarskie: Organ Polskiego Towarzystwa Lekarskiego
https://www.readbyqxmd.com/read/27716674/insula-and-inferior-frontal-gyrus-activities-protect-memory-performance-against-alzheimer-s-disease-pathology-in-old-age
#14
Feng Lin, Ping Ren, Raymond Y Lo, Benjamin P Chapman, Alanna Jacobs, Timothy M Baran, Anton P Porsteinsson, John J Foxe
Apolipoprotein E (APOE) ɛ4 carriers and patients with amnestic mild cognitive impairment (MCI) have high risk of developing Alzheimer's disease (AD). The Scaffolding Theory of Aging and Cognition proposes that recruitment of additional frontal brain regions can protect cognition against aging. This thesis has yet to be fully tested in older adults at high risk for AD. In the present study, 75 older participants (mean age: 74 years) were included. Applying a voxel-wise approach, fractional amplitude of low-frequency fluctuations (fALFF) in resting-state functional neuroimaging data were analyzed as a function of APOEɛ4 status (carrier versus noncarrier) and clinical status (healthy control [HC] versus MCI) using a 2×2 analysis of covariance (ANCOVA)...
October 4, 2016: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/27716671/effects-of-tooth-loss-and-the-apolipoprotein-e-%C3%A9-4-allele-on-mild-memory-impairment-in-the-fujiwara-kyo-study-of-japan-a-nested-case-control-study
#15
Nozomi Okamoto, Masayuki Morikawa, Nobuko Amano, Motokazu Yanagi, Shin Takasawa, Norio Kurumatani
BACKGROUND: Several studies have suggested that periodontal disease can exacerbate the pro-inflammatory status of the brain. Tooth loss is one of the alternative evaluation indices of periodontal disease. There are few data on the relationship between tooth loss and memory impairment, depending on the apolipoprotein E (APOE) ɛ4 genotype. OBJECTIVE: To determine if tooth loss is associated with mild memory impairment (MMI) and if this association is modified by the presence of the APOEɛ4 allele...
October 1, 2016: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/27709233/vitamin-c-supplementation-apoe4-genotype-and-cognitive-functioning-in-a-rural-dwelling-cohort
#16
K Chaudhari, N Sumien, L Johnson, D D'Agostino, M Edwards, R J Paxton, J R Hall, S O'Bryant
OBJECTIVE: Apolipoprotein E4 (APOE4) genotype has been implicated as a moderating factor in cognitive function studies. Although prior studies have suggested that vitamin C is associated with better cognitive function in elders, link between the two has been mixed. Limited data exist as to whether the APOE4 genotype influences these associations. Therefore, this study sought to determine whether the association between vitamin C and cognition in a rural community dwelling cohort differs by the APOE4 genotype...
2016: Journal of Nutrition, Health & Aging
https://www.readbyqxmd.com/read/27703028/apoe-genotypes-associate-with-cognitive-performance-but-not-cerebral-structure-diabetes-heart-study-mind
#17
Nicholette D Palmer Allred, Laura M Raffield, Joycelyn C Hardy, Fang-Chi Hsu, Jasmin Divers, Jianzhao Xu, S Carrie Smith, Christina E Hugenschmidt, Benjamin C Wagner, Christopher T Whitlow, Kaycee M Sink, Joseph A Maldjian, Jeff D Williamson, Donald W Bowden, Barry I Freedman
OBJECTIVE: Dementia is a debilitating illness with a disproportionate burden in patients with type 2 diabetes (T2D). Among the contributors, genetic variation at the apolipoprotein E locus (APOE) is posited to convey a strong effect. This study compared and contrasted the association of APOE with cognitive performance and cerebral structure in the setting of T2D. RESEARCH DESIGN AND METHODS: European Americans from the Diabetes Heart Study (DHS) MIND (n = 754) and African Americans from the African American (AA)- DHS MIND (n = 517) were examined...
October 4, 2016: Diabetes Care
https://www.readbyqxmd.com/read/27664990/%C3%AE-amyloid-burden-predicts-lower-extremity-performance-decline-in-cognitively-unimpaired-older-adults
#18
Qu Tian, Susan M Resnick, Murat Bilgel, Dean F Wong, Luigi Ferrucci, Stephanie A Studenski
BACKGROUND: Motor slowing is associated with risk of Alzheimer's disease. Whether β-amyloid (Aβ) burden is associated with motor decline, independent of cognitive decline, is unknown. METHODS: About 59 cognitively unimpaired older participants had baseline PET-PiB scans and repeated measures of lower (usual gait speed, 400-m time, Health ABC Physical Performance Battery (HABCPPB) score, total standing balance time) and upper (mean tapping time) extremity performance during a mean follow-up of 4...
September 24, 2016: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://www.readbyqxmd.com/read/27662317/comparison-of-gait-parameters-for%C3%A2-predicting-cognitive-decline-the%C3%A2-mayo%C3%A2-clinic-study-of-aging
#19
Rodolfo Savica, Alexandra M V Wennberg, Clinton Hagen, Kelly Edwards, Rosebud O Roberts, John H Hollman, David S Knopman, Bradley F Boeve, Mary M Machulda, Ronald C Petersen, Michelle M Mielke
BACKGROUND: Previous studies reported that slower gait speed might predict cognitive impairment and dementing illnesses, supporting the role of gait speed as a possible subclinical marker of cognitive impairment. However, the predictive value of other gait parameters for cognitive decline is unclear. OBJECTIVE: To investigate and compare the association with, and prediction of, specific gait parameters for cognition in a population-based sample. METHODS: The analysis included 3,426 cognitively normal participants enrolled in the Mayo Clinic Study of Aging...
September 23, 2016: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/27662294/increased-pcsk9-cerebrospinal-fluid-concentrations-in-alzheimer-s-disease
#20
Francesca Zimetti, Paolo Caffarra, Nicoletta Ronda, Elda Favari, Maria Pia Adorni, Ilaria Zanotti, Franco Bernini, Federica Barocco, Marco Spallazzi, Daniela Galimberti, Chiara Ricci, Massimiliano Ruscica, Alberto Corsini, Nicola Ferri
BACKGROUND: Alzheimer's disease (AD) has been associated with dysregulation of brain cholesterol trafficking and abnormal production of apolipoprotein E isoform 4 (apoE4). Proprotein convertase subtilisin/kexin type 9 (PCSK9) is a protein present in serum and cerebrospinal fluid (CSF) degrading the low-density lipoprotein receptor (LDLr) and other apoE-binding receptors involved in neuron cholesterol uptake. The role of PCSK9 in AD is controversial. OBJECTIVE: We compared PCSK9 levels in CSF of AD patients and non-AD controls and looked at correlations with CSF total apoE and apoE4...
September 20, 2016: Journal of Alzheimer's Disease: JAD
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