keyword
MENU ▼
Read by QxMD icon Read
search

Apo E4

keyword
https://www.readbyqxmd.com/read/29128786/green-space-and-cognitive-ageing-a-retrospective-life-course-analysis-in-the-lothian-birth-cohort-1936
#1
Mark P C Cherrie, Niamh K Shortt, Richard J Mitchell, Adele M Taylor, Paul Redmond, Catharine Ward Thompson, John M Starr, Ian J Deary, Jamie R Pearce
International evidence suggests that green space has beneficial effects on general and mental health but little is known about how lifetime exposure to green space influences cognitive ageing. Employing a novel longitudinal life course approach, we examined the association between lifetime availability of public parks and cognitive ageing. Lifetime residential information was gathered from the participants of the Lothian Birth Cohort 1936 using a "life-grid" questionnaire at age 78 years. Parks information from 1949, 1969 and 2009 was used to determine a percentage of parks within a 1500 m buffer zone surrounding residence for childhood, adulthood, and later adulthood periods...
November 7, 2017: Social Science & Medicine
https://www.readbyqxmd.com/read/29100334/paradoxical-effects-of-137-cs-irradiation-on-pharmacological-stimulation-of-reactive-oxygen-species-in-hippocampal-slices-from-apoe2-and-apoe4-mice
#2
Laura E Villasana, Tunde Akinyeke, Sydney Weber, Jacob Raber
In humans, apoE, which plays a role in repair, is expressed in three isoforms: E2, E3, and E4. E4 is a risk factor for age-related cognitive decline (ACD) and Alzheimer's disease (AD), particularly in women. In contrast, E2 is a protective factor for ACD and AD. E2 and E4 might also differ in their response to cranial (137)Cs irradiation, a form of radiation typically used in a clinical setting for the treatment of cancer. This might be mediated by reactive oxygen species (ROS) in an-apoE isoform-dependent fashion...
September 29, 2017: Oncotarget
https://www.readbyqxmd.com/read/29082658/cognitive-impairment-in-progressive-supranuclear-palsy-is-associated-with-tau-burden
#3
Shunsuke Koga, Adam Parks, Koji Kasanuki, Monica Sanchez-Contreras, Matthew C Baker, Keith A Josephs, J Eric Ahlskog, Ryan J Uitti, Neill Graff-Radford, Jay A van Gerpen, Zbigniew K Wszolek, Rosa Rademakers, Dennis W Dickson
BACKGROUND: Cognitive impairment is one of the core features of progressive supranuclear palsy. This study aimed to clarify the profile of cognitive impairment and its underlying pathology in progressive supranuclear palsy. METHODS: We retrospectively reviewed medical records to evaluate the pattern and severity of cognitive impairment in 121 autopsy-confirmed progressive supranuclear palsy patients. A subset of 37 patients underwent neuropsychological evaluation as part of their clinical workup...
October 30, 2017: Movement Disorders: Official Journal of the Movement Disorder Society
https://www.readbyqxmd.com/read/29081417/change-in-odor-identification-impairment-is-associated-with-improvement-with%C3%A2-cholinesterase-inhibitor-treatment-in%C3%A2-mild-cognitive-impairment
#4
D P Devanand, Cody Lentz, Richard E Chunga, Adam Ciarleglio, Jennifer M Scodes, Howard Andrews, Peter W Schofield, Yaakov Stern, Edward D Huey, Karen Bell, Gregory H Pelton
BACKGROUND: Anticholinergic challenge can induce odor identification impairment that indicates Alzheimer's disease pathology. OBJECTIVE: To determine if decline in odor identification ability with anticholinergic challenge can predict improvement with donepezil, a cholinesterase inhibitor (ChEI), in patients with mild cognitive impairment (MCI). METHODS: At baseline, the University of Pennsylvania Smell identification Test (UPSIT) was administered before and after an anticholinergic atropine nasal spray challenge...
October 21, 2017: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/29072550/association-of-glutathione-s-transferases-m1-p1-and-t1-variations-and-risk-of-late-onset-alzheimer-s-disease
#5
Zahra Jafarian, Kioomars Saliminejad, Koorosh Kamali, Mina Ohadi, Ali Kowsari, Leila Nasehi, Hamid Reza Khorram Khorshid
OBJECTIVE: Late-onset Alzheimer's disease (AD) is a genetically heterogeneous neurodegenerative disorder. Associations of the glutathione S-transferases (GSTs) polymorphisms with the risk factors for AD have not been definitely confirmed. We investigated the association of GSTM1 and GSTT1 null deletion and GSTP1 313 A/G polymorphisms and the risk of AD in an Iranian population. METHODS: The case group consisted of 280 individuals with AD and the control group included 168 age-matched healthy individuals...
October 26, 2017: Neurological Research
https://www.readbyqxmd.com/read/29070790/pattern-discovery-in-brain-imaging-genetics-via-scca-modeling-with-a-generic-non-convex-penalty
#6
Lei Du, Kefei Liu, Xiaohui Yao, Jingwen Yan, Shannon L Risacher, Junwei Han, Lei Guo, Andrew J Saykin, Li Shen
Brain imaging genetics intends to uncover associations between genetic markers and neuroimaging quantitative traits. Sparse canonical correlation analysis (SCCA) can discover bi-multivariate associations and select relevant features, and is becoming popular in imaging genetic studies. The L1-norm function is not only convex, but also singular at the origin, which is a necessary condition for sparsity. Thus most SCCA methods impose [Formula: see text]-norm onto the individual feature or the structure level of features to pursuit corresponding sparsity...
October 25, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29062035/csf-tau-is-associated-with-impaired-cortical-plasticity-cognitive-decline-and-astrocyte-survival-only-in-apoe4-positive-alzheimer-s-disease
#7
Giacomo Koch, Francesco Di Lorenzo, Stefano Loizzo, Caterina Motta, Sara Travaglione, Monica Baiula, Roberto Rimondini, Viviana Ponzo, Sonia Bonnì, Sofia Toniolo, Fabrizio Sallustio, Marco Bozzali, Carlo Caltagirone, Gabriele Campana, Alessandro Martorana
In Alzheimer's disease (AD) patients, apopoliprotein (APOE) polymorphism is the main genetic factor associated with more aggressive clinical course. However, the interaction between cerebrospinal fluid (CSF) tau protein levels and APOE genotype has been scarcely investigated. A possible key mechanism invokes the dysfunction of synaptic plasticity. We investigated how CSF tau interacts with APOE genotype in AD patients. We firstly explored whether CSF tau levels and APOE genotype influence disease progression and long-term potentiation (LTP)-like cortical plasticity as measured by transcranial magnetic stimulation (TMS) in AD patients...
October 23, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29038492/correlation-of-plasma-egf-with-striatal-dopamine-transporter-availability-in-healthy-subjects
#8
Kyoungjune Pak, Seunghyeon Shin, So Jung Kim, Keunyoung Kim, Bum Soo Kim, Seong Jang Kim, In Joo Kim
We aimed to evaluate the association between plasma epidermal growth factor (EGF) and the availability of dopamine transporter (DAT) measured from (123)I-FP-CIT single-photon emission computed tomography in healthy controls in this study. Volume of interest template was applied to measure specific binding ratios (SBRs) of caudate nucleus, putamen, and striatum representing DAT availability as follows; SBR = (target- cerebellum)/cerebellum. Plasma EGF was negatively correlated with the availabilities of both caudate nucleus (r = -0...
October 16, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29038051/integrated-approach-reveals-diet-apoe-genotype-and-sex-affect-immune-response-in-app-mice
#9
Kyong Nyon Nam, Cody M Wolfe, Nicholas F Fitz, Florent Letronne, Emilie L Castranio, Anais Mounier, Jonathan Schug, Iliya Lefterov, Radosveta Koldamova
Alzheimer's disease (AD) is a multifactorial neurodegenerative disorder that is influenced by genetic and environmental risk factors, such as inheritance of ε4 allele of APOE (APOE4), sex and diet. Here, we examined the effect of high fat diet (HFD) on amyloid pathology and expression profile in brains of AD model mice expressing human APOE isoforms (APP/E3 and APP/E4 mice). APP/E3 and APP/E4 mice were fed HFD or Normal diet for 3months. We found that HFD significantly increased amyloid plaques in male and female APP/E4, but not in APP/E3 mice...
October 14, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/29034886/generation-and-characterization-of-human-induced-pluripotent-stem-cell-hipsc-lines-from-an-alzheimer-s-disease-asui001-a-and-non-demented-control-asui002-a-patient-homozygous-for-the-apolipoprotein-e4-apoe4-risk-variant
#10
Nicholas Brookhouser, Ping Zhang, Richard Caselli, Jean J Kim, David A Brafman
Although the majority of late-onset Alzheimer's disease (AD) patients are labeled sporadic, multiple genetic risk variants have been identified, the most powerful and prevalent of which is the e4 variant of the Apolipoprotein E (APOE) gene. Here, we generated human induced pluripotent stem cell (hiPSC) lines from the peripheral blood mononuclear cells (PBMCs) of a clinically diagnosed AD patient [ASUi001-A] and a non-demented control (NDC) patient [ASUi002-A] homozygous for the APOE4 risk allele. These hiPSCs maintained their original genotype, expressed pluripotency markers, exhibited a normal karyotype, and demonstrated the ability to differentiate into cells representative of the three germ layers...
October 2017: Stem Cell Research
https://www.readbyqxmd.com/read/29016246/cognitive-dysfunction-and-single-nucleotide-polymorphisms-in-hepatitis-c-virus-infected-persons-a-systematic-review
#11
Tatiana Lins Carvalho, Raul Emídio Lima, Gustavo Henrique Belarmino Góes, Lívio Amaro Pereira, Matheus Santos de Sousa Fernandes, Patrícia Muniz Mendes Freire Moura, Luydson Richardson Silva Vasconcelos, Carolina Cunha Correia
The aim of this study was to realize a systematic review to identify data reported in the literature involving people infected by hepatitis C virus (HCV) with cognitive dysfunctions and single nucleotide polymorphisms (SNPs). The research was realized in six databases and the selection of studies was performed in two stages. Initially, we searched indexed articles from the following electronic databases: SciELO, MEDLINE, PubMed, HighWire, LILACS, and ScienceDirect. Then the articles were completely read and those that did not meet the eligibility criteria were excluded...
October 10, 2017: Viral Immunology
https://www.readbyqxmd.com/read/28984603/relation-of-odor-identification-with-alzheimer-s-disease-markers-in-cerebrospinal-fluid-and-cognition
#12
Babette L R Reijs, Inez H G B Ramakers, Lyzel Elias-Sonnenschein, Charlotte E Teunissen, Marleen Koel-Simmelink, Magda Tsolaki, Lars-Olof Wahlund, Gunhild Waldemar, Lucrezia Hausner, Peter Johannsen, Hugo Vanderstichele, Frans Verhey, D P Devanand, Pieter Jelle Visser
BACKGROUND: Impaired olfactory function is an early characteristic of Alzheimer's disease (AD), but it remains unclear if odor identification also relates to early markers of AD in cerebrospinal fluid (CSF). OBJECTIVE: To investigate the association between odor identification and amyloid-β 1-42 (Aβ42) and total tau (t-tau) concentrations in CSF. In addition, to examine the relation between odor identification and cognitive function at baseline and at follow-up, and whether these associations are moderated by CSF Aβ42 and t-tau and apolipoprotein E (APOE) genotype...
2017: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/28984595/low-prevalence-and-clinical-effect-of-vascular-risk-factors-in-early-onset-alzheimer-s-disease
#13
Yaohua Chen, Adeline Rollin Sillaire, Jean Dallongeville, Emilie Skrobala, David Wallon, Bruno Dubois, Didier Hannequin, Florence Pasquierthe
BACKGROUND: Determinants of early-onset Alzheimer's disease (EOAD) are not well known. In late-onset AD, vascular risk factors (VRFs) are associated with earlier clinical manifestation. OBJECTIVE: The objective of this study was to assess the putative association between VRFs and EOAD. METHODS: We studied participants with dementia meeting criteria for EOAD (recruited into the French CoMAJ prospective cohort study from 1 June 2009 to 28 February 2014) and age-, gender-matched controls (ratio 1:3, drawn randomly from the French MONA-LISA population-based survey between 2005 and 2007)...
2017: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/28984587/diabetes-is-not-associated-with-alzheimer-s-disease-neuropathology
#14
Maria Niures Pimentel Dos Santos Matioli, Claudia Kimie Suemoto, Roberta Diehl Rodriguez, Daniela Souza Farias, Magnólia Moreira da Silva, Renata Elaine Paraizo Leite, Renata Eloah Lucena Ferretti-Rebustini, José Marcelo Farfel, Carlos Augusto Pasqualucci, Wilson Jacob Filho, Zoe Arvanitakis, Michel Satya Naslavsky, Mayana Zatz, Lea Tenenholz Grinberg, Ricardo Nitrini
BACKGROUND: Previous evidence linking diabetes to Alzheimer's disease (AD) neuropathology is mixed and scant data are available from low- and middle-income countries. OBJECTIVE: To investigate the association between diabetes and AD neuropathology in a large autopsy study of older Brazilian adults. METHODS: In this cross-sectional study, diabetes was defined by diagnosis during life or use of antidiabetic medication. A standardized neuropathological examination was performed using immunohistochemistry...
2017: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/28975146/effect-of-apolipoprotein-e-phenotype-on-the-association-of-plasma-amyloid%C3%A2-%C3%AE-and-amyloid-positron-emission-tomography-imaging-in-japan
#15
Amane Tateno, Takeshi Sakayori, Woo Chan Kim, Michihiko Koeda, Shinichiro Kumita, Hidenori Suzuki, Yoshiro Okubo
INTRODUCTION: The plasma concentration of beta-amyloid (Aβ) has been considered another biomarker of Alzheimer's disease and was reportedly associated with cortical Aβ accumulation. METHODS: We analyzed 28 subjects with apolipoprotein E4 (ApoE4; E4 group) and 89 subjects without ApoE4 (non-E4 group) to determine the association between cortical Aβ accumulation by standard uptake value ratio with [(18)F]florbetapir positron emission tomography and plasma Aβ1-40 and Aβ1-42...
2017: Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring
https://www.readbyqxmd.com/read/28959956/apoe4-markedly-exacerbates-tau-mediated-neurodegeneration-in-a-mouse-model-of-tauopathy
#16
Yang Shi, Kaoru Yamada, Shane Antony Liddelow, Scott T Smith, Lingzhi Zhao, Wenjie Luo, Richard M Tsai, Salvatore Spina, Lea T Grinberg, Julio C Rojas, Gilbert Gallardo, Kairuo Wang, Joseph Roh, Grace Robinson, Mary Beth Finn, Hong Jiang, Patrick M Sullivan, Caroline Baufeld, Michael W Wood, Courtney Sutphen, Lena McCue, Chengjie Xiong, Jorge L Del-Aguila, John C Morris, Carlos Cruchaga, Anne M Fagan, Bruce L Miller, Adam L Boxer, William W Seeley, Oleg Butovsky, Ben A Barres, Steven M Paul, David M Holtzman
APOE4 is the strongest genetic risk factor for late-onset Alzheimer disease. ApoE4 increases brain amyloid-β pathology relative to other ApoE isoforms. However, whether APOE independently influences tau pathology, the other major proteinopathy of Alzheimer disease and other tauopathies, or tau-mediated neurodegeneration, is not clear. By generating P301S tau transgenic mice on either a human ApoE knock-in (KI) or ApoE knockout (KO) background, here we show that P301S/E4 mice have significantly higher tau levels in the brain and a greater extent of somatodendritic tau redistribution by three months of age compared with P301S/E2, P301S/E3, and P301S/EKO mice...
September 28, 2017: Nature
https://www.readbyqxmd.com/read/28957663/apolipoprotein-e4-impairs-neuronal-insulin-signaling-by-trapping-insulin-receptor-in-the-endosomes
#17
Na Zhao, Chia-Chen Liu, Alexandra J Van Ingelgom, Yuka A Martens, Cynthia Linares, Joshua A Knight, Meghan M Painter, Patrick M Sullivan, Guojun Bu
Diabetes and impaired brain insulin signaling are linked to the pathogenesis of Alzheimer's disease (AD). The association between diabetes and AD-associated amyloid pathology is stronger among carriers of the apolipoprotein E (APOE) ε4 gene allele, the strongest genetic risk factor for late-onset AD. Here we report that apoE4 impairs neuronal insulin signaling in human apoE-targeted replacement (TR) mice in an age-dependent manner. High-fat diet (HFD) accelerates these effects in apoE4-TR mice at middle age...
September 27, 2017: Neuron
https://www.readbyqxmd.com/read/28945989/apolipoprotein-e4-inhibits-autophagy-gene-products-through-direct-specific-binding-to-clear-motifs
#18
Paul A Parcon, Meenakshisundaram Balasubramaniam, Srinivas Ayyadevara, Richard A Jones, Ling Liu, Robert J Shmookler Reis, Steven W Barger, Robert E Mrak, W Sue T Griffin
INTRODUCTION: Alzheimer apolipoprotein E (APOE) ɛ4/ɛ4 carriers have earlier disease onset and more protein aggregates than patients with other APOE genotypes. Autophagy opposes aggregation, and important autophagy genes are coordinately regulated by transcription factor EB (TFEB) binding to "coordinated lysosomal expression and regulation" (CLEAR) DNA motifs. METHODS: Autophagic gene expression was assessed in brains of controls and Alzheimer's disease (AD) patients parsed by APOE genotype and in a glioblastoma cell line expressing either apoE3 or apoE4...
September 22, 2017: Alzheimer's & Dementia: the Journal of the Alzheimer's Association
https://www.readbyqxmd.com/read/28940650/polygenic-hazard-scores-in-preclinical-alzheimer-disease
#19
Chin Hong Tan, Bradley T Hyman, Jacinth J X Tan, Christopher P Hess, William P Dillon, Gerard D Schellenberg, Lilah M Besser, Walter A Kukull, Karolina Kauppi, Linda K McEvoy, Ole A Andreassen, Anders M Dale, Chun Chieh Fan, Rahul S Desikan
Identifying asymptomatic older individuals at elevated risk for developing Alzheimer disease (AD) is of clinical importance. Among 1,081 asymptomatic older adults, a recently validated polygenic hazard score (PHS) significantly predicted time to AD dementia and steeper longitudinal cognitive decline, even after controlling for APOE ɛ4 carrier status. Older individuals in the highest PHS percentiles showed the highest AD incidence rates. PHS predicted longitudinal clinical decline among older individuals with moderate to high Consortium to Establish a Registry for Alzheimer's Disease (amyloid) and Braak (tau) scores at autopsy, even among APOE ɛ4 noncarriers...
September 2017: Annals of Neurology
https://www.readbyqxmd.com/read/28939709/topography-and-determinants-of-magnetic-resonance-imaging-mri-visible-perivascular-spaces-in-a-large-memory-clinic-cohort
#20
Sara Shams, Juha Martola, Andreas Charidimou, Mykol Larvie, Tobias Granberg, Mana Shams, Maria Kristoffersen-Wiberg, Lars-Olof Wahlund
BACKGROUND: Magnetic resonance imaging-visible perivascular spaces (PVS) are related to interstitial fluid clearance pathways (including amyloid-β) in the brain and are suggested to be a marker of cerebral small vessel disease. We investigated the role, topography, and possible implications of PVS in cognitive impairment. METHODS AND RESULTS: A total of 1504 patients undergoing memory clinic investigation and an associated brain magnetic resonance imaging scan were included in this cross-sectional study...
September 22, 2017: Journal of the American Heart Association
keyword
keyword
75813
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"