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https://www.readbyqxmd.com/read/29451211/electroacupuncture-preconditioning-protects-against-focal-cerebral-ischemia-reperfusion-injury-via-suppression-of-dynamin-related-protein-1
#1
Gao-Feng Zhang, Pei Yang, Zeng Yin, Huai-Long Chen, Fu-Guo Ma, Bin Wang, Li-Xin Sun, Yan-Lin Bi, Fei Shi, Ming-Shan Wang
Electroacupuncture preconditioning at acupoint Baihui (GV20) can reduce focal cerebral ischemia/reperfusion injury. However, the precise protective mechanism remains unknown. Mitochondrial fission mediated by dynamin-related protein 1 (Drp1) can trigger neuronal apoptosis following cerebral ischemia/reperfusion injury. Herein, we examined the hypothesis that electroacupuncture pretreatment can regulate Drp1, and thus inhibit mitochondrial fission to provide cerebral protection. Rat models of focal cerebral ischemia/reperfusion injury were established by middle cerebral artery occlusion at 24 hours after 5 consecutive days of preconditioning with electroacupuncture at GV20 (depth 2 mm, intensity 1 mA, frequency 2/15 Hz, for 30 minutes, once a day)...
January 2018: Neural Regeneration Research
https://www.readbyqxmd.com/read/29451209/predictors-of-short-term-outcome-in-patients-with-acute-middle-cerebral-artery-occlusion-unsuitability-of-fluid-attenuated-inversion-recovery-vascular-hyperintensity-scores
#2
Chan-Chan Li, Xiao-Zhu Hao, Jia-Qi Tian, Zhen-Wei Yao, Xiao-Yuan Feng, Yan-Mei Yang
Fluid-attenuated inversion recovery (FLAIR) vascular hyperintensity (FVH) is used to assess leptomeningeal collateral circulation, but clinical outcomes of patients with FVH can be very different. The aim of the present study was to assess a FVH score and explore its relationship with clinical outcomes. Patients with acute ischemic stroke due to middle cerebral artery M1 occlusion underwent magnetic resonance imaging and were followed up at 10 days (National Institutes of Health Stroke Scale) and 90 days (modified Rankin Scale) to determine short-term clinical outcomes...
January 2018: Neural Regeneration Research
https://www.readbyqxmd.com/read/29421566/protecting-neurons-from-cerebral-ischemia-reperfusion-injury-via-nanoparticle-mediated-delivery-of-an-sirna-to-inhibit-microglial-neurotoxicity
#3
Ye Wang, Shi-Yong Li, Song Shen, Jun Wang
Complement component C3 (C3) plays a central role in microglial neurotoxicity following cerebral ischemia/reperfusion (I/R) injury. In this study, we focused on the role of nanoparticles loaded with C3 siRNA (NPsiC3) in inhibiting microglial neurotoxicity after brain (I/R) injury. NPsiC3 inhibited the hypoxia/re-oxygenation-induced increase in C3 expression in microglia in vitro. Importantly, treatment with NPsiC3 decreased C3b deposition on neurons and reduced microglia-mediated neuronal damage under hypoxia/re-oxygen conditions...
January 29, 2018: Biomaterials
https://www.readbyqxmd.com/read/29409115/expression-of-nerve-growth-factor-carried-by-pseudotyped-lentivirus-improves-neuron-survival-and-cognitive-functional-recovery-of-post-ischemia-in-rats
#4
Jia-Yu Cao, Yong Lin, Yan-Fei Han, Sheng-Hao Ding, Yi-Ling Fan, Yao-Hua Pan, Bing Zhao, Qin-Hua Guo, Wen-Hua Sun, Jie-Qing Wan, Xiao-Ping Tong
AIMS: Nerve growth factor (NGF) has been reported to prevent neuronal damage and contributes to the functional recovery in animal brain injury models and human ischemic disease as well. We aimed to investigate a potential therapeutic effect of NGF gene treatment in ischemic stroke and to estimate the functional recovery both at the cellular and cognitive levels in an ischemia rat model. METHODS: After microinjection of pseudolentivirus-delivered β-NGF into an established ischemic stroke model in rats (tMCAO), we estimated neuronal cell apoptosis with TUNEL labeling and neurogenesis by cell proliferation marker Ki67 staining in both ischemic core and penumbra of striatum...
February 6, 2018: CNS Neuroscience & Therapeutics
https://www.readbyqxmd.com/read/29408775/value-based-procurement-of-medical-devices-application-to-devices-for-mechanical-thrombectomy-in-ischemic-stroke
#5
Sabrina Trippoli, Erminia Caccese, Claudio Marinai, Andrea Messori
OBJECTIVES: In the acute ischemic stroke, endovascular devices have shown promising clinical results and are also likely to represent value for money, as several modeling studies have shown. Pharmacoeconomic evaluations in this field, however, have little impact on the procurement of these devices. The present study explored how complex pharmacoeconomic models that evaluate effectiveness and cost can be incorporated into the in-hospital procurement of thrombectomy devices. PATIENTS AND METHODS: As regards clinical modeling, we extracted outcomes at three months from randomized trials conducted for four thrombectomy devices, and we projected long-term results using standard Markov modeling...
January 29, 2018: Clinical Neurology and Neurosurgery
https://www.readbyqxmd.com/read/29402060/penumbral-imaging-based-thrombolysis-with-tenecteplase-is-feasible-up-to-24-hours-after-symptom-onset
#6
Mahesh Kate, Robert Wannamaker, Harsha Kamble, Parnian Riaz, Laura C Gioia, Brian Buck, Thomas Jeerakathil, Penelope Smyth, Ashfaq Shuaib, Kenneth Butcher, Derek Emery
BACKGROUND AND PURPOSE: Thrombolysis >4.5 hours after ischemic stroke onset is unproven. We assessed the feasibility of tenecteplase (TNK) treatment in patients with evidence of an ischemic penumbra 4.5 to 24 hours after onset. METHODS: Acute ischemic stroke patients underwent perfusion computed tomography (CT)/magnetic resonance imaging. Patients with cerebral blood volume (CBV) or diffusion weighted imaging Alberta Stroke Program Early CT Scores (ASPECTS) >6 and mismatch score >2 (defined as >2 ASPECTS regions with delay on mean transit time maps and normal CBV) were eligible for treatment with TNK (0...
January 2018: Journal of Stroke
https://www.readbyqxmd.com/read/29399075/impact-of-collateral-circulation-status-on-favorable-outcomes-in-thrombolysis-treatment-a-systematic-review-and-meta-analysis
#7
Alimu Wufuer, Atikaimu Wubuli, Peierdun Mijiti, Jun Zhou, Shabier Tuerxun, Jian Cai, Jianhua Ma, Xiaoning Zhang
Collateral circulation affects the prognosis of patients with acute ischemic stroke (AIS) treated by thrombolysis. The present study performed a systematic assessment of the impact of the collateral circulation status on the outcomes of patients receiving thrombolysis treatment. Relevant full-text articles from the Cochrane Library, Ovid, Medline, Embase and PubMed databases published from January 1, 2000 to November 1, 2016 were retrieved. The quality of the studies was assessed and data were extracted by 2 independent investigators...
January 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29383122/antioxidant-and-pro-angiogenic-effects-of-corilagin-in-rat-cerebral-ischemia-via-nrf2-activation
#8
Yi Ding, Danjun Ren, Hang Xu, Wenxing Liu, Tianlong Liu, Liang Li, Jianguang Li, Yuwen Li, AiDong Wen
The nuclear factor erythroid-2-related factor 2 (Nrf2) pathway has been considered as a potential target for neuroprotection in stroke. The aim of present study was to determine whether corilagin, a novel Nrf2 activator, can protect against ischemia-reperfusion injury and explore the underlying mechanism involved. In vivo, rats exposed to middle cerebral artery occlusion were applied to establish an ischemic stroke model. Posttreatment of corilagin significantly reduced infarct volumes and apoptotic cells as well as improved neurologic score after reperfusion, together with increased vascular density in the ischemic penumbra...
December 29, 2017: Oncotarget
https://www.readbyqxmd.com/read/29370523/revealing-the-penumbra-through-imaging-elemental-markers-of-cellular-metabolism-in-an-ischemic-stroke-model
#9
M Jake Pushie, Andrew Crawford, Nicole J Sylvain, Huishu Hou, Mark J Hackett, Graham N George, Michael E Kelly
Stroke exacts a heavy financial and economic burden, is a leading cause of death, and the leading cause of long term disability in those who survive. The penumbra surrounds the ischemic core of the stroke lesion and is comprised of metabolically stressed cells that may become part of the growing infarct or can potentially recover. Preserving the penumbra to promote functional recovery is a central goal in stroke research. Using synchrotron-based X-ray fluorescence imaging the elemental changes in brain tissue following ischemic stroke can be visualized...
January 25, 2018: ACS Chemical Neuroscience
https://www.readbyqxmd.com/read/29364137/development-of-stereotactic-radiosurgery-using-carbon-beams-carbon-knife
#10
Mintra Keawsamur, Akihiko Matsumura, Hikaru Souda, Yosuke Kano, Masami Torikoshi, Takashi Nakano, Tatsuaki Kanai
The aim of this research is to develop a stereotactic-radiosurgery (SRS) technique using carbon beams to treat small intracranial lesions; we call this device the carbon knife. A 2D-scanning method is adapted to broaden a pencil beam to an appropriate size for an irradiation field. A Mitsubishi slow extraction using third order resonance through rf acceleration system stabilized by a feed-forward scanning beam using steering magnets with a 290-MeV/u initial beam energy was used for this purpose. Ridge filters for spread-out Bragg peaks (SOBPs) with widths of 5 mm, 7...
January 24, 2018: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/29360494/new-roles-of-reactive-astrocytes-in-the-brain-an-organizer-of-cerebral-ischemia
#11
Schuichi Koizumi, Yuri Hirayama, Yosuke M Morizawa
The brain consists of neurons and much higher number of glial cells. They communicate each other, by which they control brain functions. The brain is highly vulnerable to several insults such as ischemia, but has a self-protective and self-repairing mechanisms against these. Ischemic tolerance or preconditioning is an endogenous neuroprotective phenomenon, where a mild non-lethal ischemic episode can induce resistance to a subsequent severe ischemic injury in the brain. Because of its neuroprotective effects against cerebral ischemia or stroke, ischemic tolerance has been widely studied...
January 19, 2018: Neurochemistry International
https://www.readbyqxmd.com/read/29356965/nkg2d-ligands-in-glioma-stem-like-cells-expression-in-situ-and-in-vitro
#12
Charlotte Flüh, Guranda Chitadze, Vivian Adamski, Kirsten Hattermann, Michael Synowitz, Dieter Kabelitz, Janka Held-Feindt
Glioblastoma multiforme (GBM) is a highly malignant brain tumor. Tumor stem cells have a major influence on tumor malignancy, and immunological escape mechanisms, involving the Natural Killer Group 2, member D (NKG2D) receptor-ligand-system, are key elements in tumor immuno-surveillance. We analyzed the expression profile and localization of NKG2D ligands (NKG2DL) and embryonic and neural stem cell markers in solid human GBM and stem-like cells isolated from glioma cell lines by qRT-PCR and immunohistochemistry, including quantitative analysis...
January 22, 2018: Histochemistry and Cell Biology
https://www.readbyqxmd.com/read/29342941/development-of-optical-fiber-based-measurement-system-for-the-verification-of-entrance-dose-map-in-pencil-beam-scanning-proton-beam
#13
Jaeman Son, Se Byeong Lee, Youngkyung Lim, Sung Yong Park, Kwanho Cho, Myonggeun Yoon, Dongho Shin
This study describes the development of a beam monitoring system for the verification of entrance dose map in pencil beam scanning (PBS) proton therapy based on fiber optic radiation sensors (FORS) and the validation of this system through a feasibility study. The beam monitoring system consisted of 128 optical fibers optically coupled to photo-multiplier tubes. The performance of the beam monitoring system based on FORS was verified by comparing 2D dose maps of square-shaped fields of various sizes, which were obtained using conventional dosimeters such as MatriXX and EBT3 film, with those measured using FORS...
January 15, 2018: Sensors
https://www.readbyqxmd.com/read/29337840/targeted-temperature-management-at-33%C3%A2-c-or-36%C3%A2-c-produces-equivalent-neuroprotective-effects-in-the-middle-cerebral-artery-occlusion-rat-model-of-ischemic-stroke
#14
Jung Ho Lee, Jisoo Lim, Yong Eun Chung, Sung Phil Chung, Incheol Park, Chul Hoon Kim, Je Sung You
Targeted temperature management (TTM, 32°C to 36°C) is one of the most successful achievements in modern resuscitation medicine. It has become standard treatment for survivors of sudden cardiac arrest to minimize secondary brain damage. TTM at 36°C is just as effective as TTM at 33°C and is actually preferred because it reduces adverse TTM-associated effects. TTM also likely has direct neuroprotective effects in ischemic brains in danger of stroke. It remains unclear, however, whether higher temperature TTM is equally effective in protecting the brain from the effects of stroke...
January 15, 2018: Shock
https://www.readbyqxmd.com/read/29324441/a-study-of-lateral-fall-off-penumbra-optimisation-for-pencil-beam-scanning-pbs-proton-therapy
#15
C Winterhalter, A Lomax, D Oxley, D C Weber, S Safai
The lateral fall-off is crucial for sparing organs at risk in proton therapy. It is therefore of high importance to minimize the penumbra for pencil beam scanning (PBS). Three optimisation approaches are investigated: edge-collimated uniformly weighted spots (collimation), pencil beam optimisation of uncollimated pencil beams (edge-enhancement) and the optimisation of edge collimated pencil beams (collimated edge-enhancement). To deliver energies below 70 MeV, these strategies are evaluated in combination with the following pre-absorber methods: field specific fixed thickness pre-absorption (fixed), range specific, fixed thickness pre-absorption (automatic) and range specific, variable thickness pre-absorption (variable)...
January 11, 2018: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/29315561/faim2-contributes-to-neuroprotection-by-erythropoietin-in-transient-brain-ischemia
#16
Daniel Komnig, Karen Gertz, Pardes Habib, Kay W Nolte, Tareq Meyer, Marc A Brockmann, Matthias Endres, Birgit Rathkolb, Martin Hrabě de Angelis, Jörg B Schulz, Björn H Falkenburger, Arno Reich
Delayed cell death in the penumbra region of acute ischemic stroke occurs through apoptotic mechanisms, making it amenable to therapeutic interventions. Fas/CD95 mediates apoptotic cell death in response to external stimuli. In mature neurons, Fas/CD95 signaling is modulated by Fas-apoptotic inhibitory molecule 2 (Faim2), which reduces cell death in animal models of stroke, meningitis, and Parkinson disease. Erythropoietin (EPO) has been studied as a therapeutic strategy in ischemic stroke. Erythropoietin stimulates the phosphatidylinositol-3 kinase/Akt (PI3K/Akt) pathway, which regulates Faim2 expression...
January 8, 2018: Journal of Neurochemistry
https://www.readbyqxmd.com/read/29314051/water-equivalent-presage%C3%A2-for-synchrotron-radiation-therapy-dosimetry
#17
Frank M Gagliardi, Liam Day, Christopher M Poole, Rick D Franich, Moshi Geso
PURPOSE: Synchrotron Radiation Therapy techniques are currently being trialled and commissioned at synchrotrons around the world. The patient treatment planning systems (TPS) developed for these treatments use simulated data of the synchrotron x-ray beam to produce the dosimetry in the treatment plan. The purpose of this study was to investigate a water equivalent PRESAGE® dosimeter capable of 3D dosimetry over an energy range suitable for synchrotron x-ray beams. METHODS: Water equivalent PRESAGE® dosimeters were fabricated with a radiological effective atomic number similar to water over an energy range of 10 keV to 10 MeV...
January 3, 2018: Medical Physics
https://www.readbyqxmd.com/read/29299743/basic-fibroblast-growth-factor-protects-astrocytes-against-ischemia-reperfusion-injury-by-upregulating-the-caveolin-1-vegf-signaling-pathway
#18
Meixia Liu, Yudan Wu, Yidian Liu, Zhenzhen Chen, Shujuan He, Huimei Zhang, Liang Wu, Fengxia Tu, Yun Zhao, Chan Liu, Xiang Chen
A previous in vivo study demonstrated that intracerebroventricular injection of basic fibroblast growth factor (bFGF) in middle cerebral artery occlusion rats increased the expression of caveolin-1 (cav-1) and vascular endothelial growth factor (VEGF) in cerebral ischemia penumbra. Because astrocytes are the largest population in the brain, the aim of this in vitro study was to investigate the influence of bFGF on cav-1 and VEGF expression in rat astrocytes following oxygen glucose deprivation/reoxygenation (OGD/R)...
January 3, 2018: Journal of Molecular Neuroscience: MN
https://www.readbyqxmd.com/read/29298858/in-vitro-measurement-of-the-permeability-of-endovascular-coils-deployed-in-cerebral-aneurysms
#19
Chander Sadasivan, Erica Swartwout, Ari D Kappel, Henry H Woo, David J Fiorella, Barry B Lieber
BACKGROUND AND PURPOSE: Aneurysm recurrence is the primary limitation of endovascular coiling treatment for cerebral aneurysms. Coiling is currently quantified by a volumetric porosity measure called packing density (pd). Blood flow through a coil mass depends on the permeability of the coil mass, and not just its pd. The permeability of coil masses has not yet been quantified. Here we measure coil permeability with a traditional falling-head permeameter modified to incorporate idealized aneurysms...
January 3, 2018: Journal of Neurointerventional Surgery
https://www.readbyqxmd.com/read/29298658/hemopexin-promotes-angiogenesis-via-up-regulating-ho-1-in-rats-after-cerebral-ischemia-reperfusion-injury
#20
Beibei Dong, Zhishen Zhang, Keliang Xie, Yongyan Yang, Yuan Shi, Chenxu Wang, Yonghao Yu
BACKGROUND: Ischemia-reperfusion (I/R) is a critical pathophysiological change of ischemic stroke. Heme-oxygenase-1 (HO-1) is a rate-limiting enzyme of eliminating excessive free heme by combining with hemopexin (HPX), a plasma protein contributing to alleviating infarct size due to ischemia stroke. This study was to investigate whether HPX could improve angiogenesis after cerebral ischemia-reperfusion via up-regulating HO-1. METHODS: Rats were randomly divided into five groups: sham, MCAO, MCAO + Vehicle, MCAO + HPX and MCAO + HPX + protoporphyrin IX (ZnPPIX, an HO-1 inhibitor)...
January 3, 2018: BMC Anesthesiology
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