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https://www.readbyqxmd.com/read/28536045/toward-defining-deep-brain-stimulation-targets-in-mni-space-a-subcortical-atlas-based-on-multimodal-mri-histology-and-structural-connectivity
#1
REVIEW
Siobhan Ewert, Philip Plettig, Ningfei Li, Mallar Chakravarty, Louis Collins, Todd Herrington, Andrea Kühn, Andreas Horn
Three-dimensional atlases of subcortical brain structures are valuable tools to reference anatomy in neuroscience and neurology. For instance, they can be used to study the position and shape of the three most common deep brain stimulation (DBS) targets, the subthalamic nucleus (STN), internal part of the pallidum (GPi) and ventral intermediate nucleus of the thalamus (VIM) in stereotactic space and in spatial relationship to DBS electrodes. Here, we present a composite atlas that is based on manual segmentations of a multimodal high resolution brain template, histology and structural connectivity...
May 20, 2017: NeuroImage
https://www.readbyqxmd.com/read/28416453/high-resolution-data-analysis-strategies-for-mesoscale-human-functional-mri-at-7-and-9-4t
#2
Valentin G Kemper, Federico De Martino, Thomas C Emmerling, Essa Yacoub, Rainer Goebel
The advent of ultra-high field functional magnetic resonance imaging (fMRI) has greatly facilitated submillimeter resolution acquisitions (voxel volume below (1mm³)), allowing the investigation of cortical columns and cortical depth dependent (i.e. laminar) structures in the human brain. Advanced data analysis techniques are essential to exploit the information in high resolution functional measures. In this article, we use recent, exemplary 9.4T human functional and anatomical data to review the advantages and disadvantages of (1) pooling high resolution data across regions of interest for cortical depth profile analysis, (2) pooling across cortical depths for mapping patches of cortex while discarding depth-dependent (i...
April 14, 2017: NeuroImage
https://www.readbyqxmd.com/read/28397316/proposed-expansion-margins-for-planning-organ-at-risk-volume-for-lenses-during-radiation-therapy-of-the-nasal-cavity-in-dogs-and-cats
#3
Zaki Jafry, Arnon Gal, Andre Fleck, Johnson Darko, Valerie J Poirier
Radiation therapy protocols for the feline or canine nasal cavity can damage epithelial cells of the posterior pole of the lens and lead to the development of cataracts. Aims of this retrospective, descriptive study were to calculate movements of the lens during radiation therapy of the nasal cavity in a sample of cats and dogs, and to propose species-specific expansion margins for planning organ at risk volume (PRV) to minimize radiation doses to the lens. All included patients were immobilized with an indexed bite block and positioned in a vacuum positioning cushion for head irradiation...
April 11, 2017: Veterinary Radiology & Ultrasound
https://www.readbyqxmd.com/read/28365421/quantitative-validation-of-a-nonlinear-histology-mri-coregistration-method-using-generalized-q-sampling-imaging-in-complex-human-cortical-white-matter
#4
Mihika Gangolli, Laurena Holleran, Joong Hee Kim, Thor D Stein, Victor Alvarez, Ann C McKee, David L Brody
Advanced diffusion MRI methods have recently been proposed for detection of pathologies such as traumatic axonal injury and chronic traumatic encephalopathy which commonly affect complex cortical brain regions. However, radiological-pathological correlations in human brain tissue that detail the relationship between the multi-component diffusion signal and underlying pathology are lacking. We present a nonlinear voxel based two dimensional coregistration method that is useful for matching diffusion signals to quantitative metrics of high resolution histological images...
March 30, 2017: NeuroImage
https://www.readbyqxmd.com/read/28338529/dosimetry-software-hermes-internal-radiation-dosimetry-from-quantitative-image-reconstruction-to-voxel-level-absorbed-dose-distribution
#5
Eero T Hippeläinen, Mikko J Tenhunen, Hanna O Mäenpää, Jorma J Heikkonen, Antti O Sohlberg
OBJECTIVE: The aim of this work is to validate a software package called Hermes Internal Radiation Dosimetry (HIRD) for internal dose assessment tailored for clinical practice. The software includes all the necessary steps to perform voxel-level absorbed dose calculations including quantitative reconstruction, image coregistration and volume of interest tools. METHODS: The basics of voxel-level dosimetry methods and implementations to HIRD software are reviewed...
May 2017: Nuclear Medicine Communications
https://www.readbyqxmd.com/read/28336927/combination-of-electroencephalography-and-near-infrared-spectroscopy-in-evaluation-of-mental-concentration-during-the-mental-focus-task-for-wisconsin-card-sorting-test
#6
Che-Wei Chen, Chia-Wei Sun
Near-infrared spectroscopy (NIRS) is a noninvasive neuroimaging tool for measuring evoked functional changes in brain oxygenation. Electroencephalography (EEG) can be used to evaluate the functionality of cortical connections and obtain information on regional cortical activity. Coregistration of EEG-NIRS is a recent technique that has been applied for measuring changes in electrical and hemodynamic activity in the human brain. EEG-NIRS coregistration facilitates the avoidance of misleading interpretations of NIRS, particularly in the diagnosis of neurological disorders...
March 23, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28323091/age-related-differences-in-functional-synchronization-of-eeg-activity-as-evaluated-by-means-of-tms-eeg-coregistrations
#7
Florinda Ferreri, Fabrizio Vecchio, Andrea Guerra, Francesca Miraglia, David Ponzo, Luca Vollero, Giulio Iannello, Sara Maatta, Esa Mervaala, Paolo Maria Rossini, Vincenzo Di Lazzaro
It was recently demonstrated that the characteristics of EEG rhythms preceding a transcranial magnetic stimulation (TMS) of the motor cortex (M1) influence the motor-evoked potential (MEP) amplitude with a peculiar pattern, thus reflecting the M1 functional state. As physiological aging is related to a decrease in motor performance and changes in excitability and connectivity strength within cerebral sensorimotor circuits, we aimed to explore whether aging affects EEG-MEP interactions. Using MRI-navigated TMS and multichannel EEG, we compared the EEG-MEP interactions observed in healthy aged subjects with those observed in young volunteers...
March 18, 2017: Neuroscience Letters
https://www.readbyqxmd.com/read/28287070/coregistration-of-multimodal-imaging-is-associated-with-favourable-two-year-seizure-outcome-after-paediatric-epilepsy-surgery
#8
Michael Scott Perry, Laurie Bailey, Daniel Freedman, David Donahue, Saleem Malik, Hayden Head, Cynthia Keator, Angel Hernandez
Multimodal coregistration uses multiple image datasets coregistered to an anatomical reference (i.e. MRI), allowing multiple studies to be viewed together. Commonly used in intractable epilepsy evaluation and generally accepted to improve localization of the epileptogenic zone, data showing that coregistration improves outcome is lacking. We compared seizure freedom following epilepsy surgery in paediatric patients, evaluated before and after the use of coregistration protocols at our centre, to determine whether this correlated with a change in outcome...
March 8, 2017: Epileptic Disorders: International Epilepsy Journal with Videotape
https://www.readbyqxmd.com/read/28286871/semiautomated-workflow-for-clinically-streamlined-glioma-parametric-response-mapping
#9
Lauren Keith, Brian D Ross, Craig J Galbán, Gary D Luker, Stefanie Galbán, Binsheng Zhao, Xiaotao Guo, Thomas L Chenevert, Benjamin A Hoff
Management of glioblastoma multiforme remains a challenging problem despite recent advances in targeted therapies. Timely assessment of therapeutic agents is hindered by the lack of standard quantitative imaging protocols for determining targeted response. Clinical response assessment for brain tumors is determined by volumetric changes assessed at 10 weeks post-treatment initiation. Further, current clinical criteria fail to use advanced quantitative imaging approaches, such as diffusion and perfusion magnetic resonance imaging...
December 2016: Tomography: a Journal for Imaging Research
https://www.readbyqxmd.com/read/28283747/magnetic-resonance-diffusion-tensor-imaging-for-the-pedunculopontine-nucleus-proof-of-concept-and-histological-correlation
#10
A T D L Alho, C Hamani, E J L Alho, R E da Silva, G A B Santos, R C Neves, L L Carreira, C M M Araújo, G Magalhães, D B Coelho, M C Alegro, M G M Martin, L T Grinberg, C A Pasqualucci, H Heinsen, E T Fonoff, E Amaro
The pedunculopontine nucleus (PPN) has been proposed as target for deep brain stimulation (DBS) in patients with postural instability and gait disorders due to its involvement in muscle tonus adjustments and control of locomotion. However, it is a deep-seated brainstem nucleus without clear imaging or electrophysiological markers. Some studies suggested that diffusion tensor imaging (DTI) may help guiding electrode placement in the PPN by showing the surrounding fiber bundles, but none have provided a direct histological correlation...
March 10, 2017: Brain Structure & Function
https://www.readbyqxmd.com/read/28267361/volume-navigation-technique-for-ultrasound-guided-biopsy-of-breast-lesions-detected-only-at-mri
#11
Erkin Aribal, Derya Tureli, Fikret Kucukkaya, Handan Kaya
OBJECTIVE: The purpose of this study is to assess the utility of a volume navigation technique (VNT) for ultrasound-guided biopsy of MRI-detected, but sonographically ambiguous or occult, breast lesions. SUBJECTS AND METHODS: Within a recruitment period of 13 months (January 1, 2014, through February 1, 2015), 22 patients with 26 BI-RADS category 4 or 5 lesions that were detected at MRI but missed at second-look ultrasound were reimaged using a rapid sequence and a flexible body coil in a 3-T MRI scanner...
March 7, 2017: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/28266747/spatial-coregistration-of-functional-near-infrared-spectroscopy-to-brain-mri
#12
Michelle Chen, Helena M Blumen, Meltem Izzetoglu, Roee Holtzer
BACKGROUND AND PURPOSE: Traditional neuroimaging techniques restrict movement and make it difficult to study the processes that require oral, upper limb, or lower limb motor execution. Functional near-infrared spectroscopy (fNIRS) is an optical neuroimaging modality that measures brain oxygenation and permits movement during data acquisition. A key limitation of fNIRS, however, is the lack of a standard method to coregister quantitative fNIRS measurements to structural images such as magnetic resonance imaging (MRI)...
March 7, 2017: Journal of Neuroimaging: Official Journal of the American Society of Neuroimaging
https://www.readbyqxmd.com/read/28264984/the-lateral-occipital-cortex-is-selective-for-object-shape-not-texture-color-at-six-months
#13
Lauren L Emberson, Stephen L Crosswhite, John E Richards, Richard N Aslin
Understanding how the human visual system develops is crucial to understanding the nature and organization of our complex and varied visual representations. However, previous investigations of the development of the visual system using fMRI are primarily confined to a subset of the visual system (high-level vision: faces, scenes) and relatively late in visual development (starting at 4-5 years of age). The current study extends our understanding of human visual development by presenting the first systematic investigation of a mid-level visual region [the lateral occipital cortex (LOC)] in a population much younger than has been investigated in the past: 6 month olds...
March 29, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/28263422/correlation-between-fluorodeoxyglucose-hotspots-on-pretreatment-positron-emission-tomography-ct-and-preferential-sites-of-local-relapse-after-chemoradiotherapy-for-head-and-neck-squamous-cell-carcinoma
#14
Anne Chaput, Jérémie Calais, Philippe Robin, Sébastien Thureau, David Bourhis, Romain Modzelewski, Ulrike Schick, Pierre Vera, Pierre-Yves Salaün, Ronan Abgral
BACKGROUND: The potential benefits of (18) F-fluoro-2-deoxy-D-glucose-positron emission tomography/CT (FDG-PET/CT) imaging for radiotherapy (RT) treatment planning of head and neck squamous cell carcinoma (HNSCC) are increasingly being recognized. It has been suggested that intratumoral subvolumes with high FDG avidity ("hotspots") are potential targets for selected dose escalation. The purposes of this study were to demonstrate that pre-RT FDG-PET/CT can identify intratumoral sites at increased risk of local relapse after RT and to determine an optimal threshold to delineate smaller RT target volumes that would facilitate RT dose escalation without impaired tolerance...
March 6, 2017: Head & Neck
https://www.readbyqxmd.com/read/28255030/a-multiparametric-model-for-mapping-cellularity-in-glioblastoma-using-radiographically-localized-biopsies
#15
P D Chang, H R Malone, S G Bowden, D S Chow, B J A Gill, T H Ung, J Samanamud, Z K Englander, A M Sonabend, S A Sheth, G M McKhann, M B Sisti, L H Schwartz, A Lignelli, J Grinband, J N Bruce, P Canoll
BACKGROUND AND PURPOSE: The complex MR imaging appearance of glioblastoma is a function of underlying histopathologic heterogeneity. A better understanding of these correlations, particularly the influence of infiltrating glioma cells and vasogenic edema on T2 and diffusivity signal in nonenhancing areas, has important implications in the management of these patients. With localized biopsies, the objective of this study was to generate a model capable of predicting cellularity at each voxel within an entire tumor volume as a function of signal intensity, thus providing a means of quantifying tumor infiltration into surrounding brain tissue...
March 2, 2017: AJNR. American Journal of Neuroradiology
https://www.readbyqxmd.com/read/28245866/structural-cartilage-damage-attracts-circulating-rheumatoid-arthritis-synovial-fibroblasts-into-affected-joints
#16
Jan Hillen, Christiane Geyer, Marianne Heitzmann, Denise Beckmann, Annika Krause, Ina Winkler, Hermann Pavenstädt, Christoph Bremer, Thomas Pap, Adelheid Korb-Pap
BACKGROUND: Rheumatoid arthritis synovial fibroblasts (RASFs) are known to travel via the bloodstream from sites of cartilage destruction to new locations where they reinitiate the destructive processes at distant articular cartilage surfaces. In this study, we examined the role of interleukin (IL)-1-induced cartilage changes and their chemotactic effect on RASF transmigratory capacity. METHODS: To investigate synovial fibroblast (SF) transmigration through endothelial layers, we used a modified Boyden chamber with an endothelioma cell layer (bEnd...
February 28, 2017: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/28192130/ielvis-an-open-source-matlab-toolbox-for-localizing-and-visualizing-human-intracranial-electrode-data
#17
David M Groppe, Stephan Bickel, Andrew R Dykstra, Xiuyuan Wang, Pierre Mégevand, Manuel R Mercier, Fred A Lado, Ashesh D Mehta, Christopher J Honey
BACKGROUND: Intracranial electrical recordings (iEEG) and brain stimulation (iEBS) are invaluable human neuroscience methodologies. However, the value of such data is often unrealized as many laboratories lack tools for localizing electrodes relative to anatomy. To remedy this, we have developed a MATLAB toolbox for intracranial electrode localization and visualization, iELVis. NEW METHOD: iELVis uses existing tools (BioImage Suite, FSL, and FreeSurfer) for preimplant magnetic resonance imaging (MRI) segmentation, neuroimaging coregistration, and manual identification of electrodes in postimplant neuroimaging...
February 10, 2017: Journal of Neuroscience Methods
https://www.readbyqxmd.com/read/28183437/cardiac-3d-printing-and-its-future-directions
#18
REVIEW
Marija Vukicevic, Bobak Mosadegh, James K Min, Stephen H Little
Three-dimensional (3D) printing is at the crossroads of printer and materials engineering, noninvasive diagnostic imaging, computer-aided design, and structural heart intervention. Cardiovascular applications of this technology development include the use of patient-specific 3D models for medical teaching, exploration of valve and vessel function, surgical and catheter-based procedural planning, and early work in designing and refining the latest innovations in percutaneous structural devices. In this review, we discuss the methods and materials being used for 3D printing today...
February 2017: JACC. Cardiovascular Imaging
https://www.readbyqxmd.com/read/28168935/reproducibility-of-a-noninvasive-system-for-eye-positioning-and-monitoring-in-stereotactic-radiotherapy-of-ocular-melanoma
#19
Omar Iskanderani, Dominique Béliveau-Nadeau, Robert Doucet, Geneviève Coulombe, Deborah Pascale, David Roberge
PURPOSE: Our preferred treatment for juxtapapillary choroidal melanoma is stereotactic radiotherapy. We aim to describe our immobilization system and quantify its reproducibility. MATERIALS AND METHODS: Patients were identified in our radiosurgery database. Patients were imaged at computed tomography simulator with an in-house system which allows visual monitoring of the eye as the patient fixates a small target. All patients were reimaged at least once prior to and/or during radiotherapy...
January 1, 2017: Technology in Cancer Research & Treatment
https://www.readbyqxmd.com/read/28157882/phase-ratio-imaging-as-applied-to-desert-sands-for-tracking-human-presence
#20
Alex J Yuffa, Vadym Kaydash, Viktor Korokhin, Yuriy Shkuratov, Evgenij Zubko, Gorden Videen
The phase function is a measure of the light-scattered intensity, or radiance, as a function of scattering angle θ. A phase ratio is the ratio of two values of the phase function measured at different scattering angles and relates to the slope of the phase function. By taking the ratio of two images acquired at different illumination or observation conditions, a phase-ratio image can be constructed. Such images accentuate differences in the phase curves, rather than their intensities, and are more sensitive to microtopography than to material properties...
January 20, 2017: Applied Optics
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