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https://www.readbyqxmd.com/read/28086965/probabilistic-liver-atlas-construction
#1
Esther Dura, Juan Domingo, Guillermo Ayala, Luis Marti-Bonmati, E Goceri
BACKGROUND: Anatomical atlases are 3D volumes or shapes representing an organ or structure of the human body. They contain either the prototypical shape of the object of interest together with other shapes representing its statistical variations (statistical atlas) or a probability map of belonging to the object (probabilistic atlas). Probabilistic atlases are mostly built with simple estimations only involving the data at each spatial location. RESULTS: A new method for probabilistic atlas construction that uses a generalized linear model is proposed...
January 13, 2017: Biomedical Engineering Online
https://www.readbyqxmd.com/read/28055101/high-resolution-imaging-of-intraretinal-structures-in-active-and-resolved-central-serous-chorioretinopathy
#2
Ryan N Vogel, Christopher S Langlo, Drew Scoles, Joseph Carroll, David V Weinberg, Judy E Kim
Purpose: We improved our understanding of central serous chorioretinopathy (CSC), we performed an analysis of noninvasive, high-resolution retinal imaging in patients with active and resolved CSC. Methods: Adaptive optics scanning light ophthalmoscopy (AOSLO) and spectral-domain optical coherence tomography (SD-OCT) were performed on five subjects with CSC. A custom AOSLO system was used to simultaneously collect confocal and split-detector images. Spectral domain-OCT volume scans were used to create en face views of various retinal layers, which then were compared to montaged AOSLO images after coregistration...
January 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28046288/we-de-201-06-impact-of-temporal-image-coregistration-methods-on-3d-internal-dose-calculations-in-targeted-radionuclide-therapy
#3
A Besemer, I Marsh, B Bednarz
PURPOSE: The calculation of 3D internal dose calculations in targeted radionuclide therapy requires the acquisition and temporal coregistration of a serial PET/CT or SPECT/CT images. This work investigates the dosimetric impact of different temporal coregistration methods commonly used for 3D internal dosimetry. METHODS: PET/CT images of four mice were acquired at 1, 24, 48, 72, 96, 144 hrs post-injection of (124) I-CLR1404. The therapeutic (131) I-CLR1404 absorbed dose rate (ADR) was calculated at each time point using a Geant4-based MC dosimetry platform using three temporal image coregistration METHODS: (1) no coregistration (NC), whole body sequential CT-CT affine coregistration (WBAC), and individual sequential ROI-ROI affine coregistration (IRAC)...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28045733/pet-mri-coregistration-in-intractable-epilepsy-and-gray-matter-heterotopia
#4
Nikhil Seniaray, Anuj Jain
A 25-year-old woman with intractable seizures underwent FDG PET/MRI for seizure focus localization. MRI demonstrated bilateral carpetlike nodular subependymal gray matter and asymmetrical focal dilatation in the right temporal horn. PET/MRI showed increased FDG within subependymal gray matter with significant hypometabolism in right anterior temporal lobe. EEG and ictal semiology confirmed the right temporal seizure origin. This case highlights the importance of identification of gray matter heterotopia on FDG PET/MRI...
December 30, 2016: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/28003137/a-feasible-and-automatic-free-tool-for-t1-and-ecv-mapping
#5
Luisa Altabella, Cristian Borrazzo, Marco Carnì, Nicola Galea, Marco Francone, Andrea Fiorelli, Elisabetta Di Castro, Carlo Catalano, Iacopo Carbone
PURPOSE: Cardiac magnetic resonance (CMR) is a useful non-invasive tool for characterizing tissues and detecting myocardial fibrosis and edema. Estimation of extracellular volume fraction (ECV) using T1 sequences is emerging as an accurate biomarker in cardiac diseases associated with diffuse fibrosis. In this study, automatic software for T1 and ECV map generation consisting of an executable file was developed and validated using phantom and human data. METHODS: T1 mapping was performed in phantoms and 30 subjects (22 patients and 8 healthy subjects) on a 1...
December 18, 2016: Physica Medica: PM
https://www.readbyqxmd.com/read/27992512/68ga-trap-rgd-3-hybrid-imaging-for-the-in-vivo-monitoring-of-%C3%AE-v%C3%A3-3-integrin-expression-as-biomarker-of-anti-angiogenic-therapy-effects-in-experimental-breast-cancer
#6
Philipp M Kazmierczak, Andrei Todica, Franz-Josef Gildehaus, Heidrun Hirner-Eppeneder, Matthias Brendel, Ralf S Eschbach, Magdalena Hellmann, Konstantin Nikolaou, Maximilian F Reiser, Hans-Jürgen Wester, Saskia Kropf, Axel Rominger, Clemens C Cyran
OBJECTIVES: To investigate 68Ga-TRAP-(RGD)3 hybrid imaging for the in vivo monitoring of αvß3-integrin expression as biomarker of anti-angiogenic therapy effects in experimental breast cancer. MATERIALS AND METHODS: Human breast cancer (MDA-MB-231) xenografts were implanted orthotopically into the mammary fat pads of n = 25 SCID mice. Transmission/emission scans (53 min to 90 min after i.v. injection of 20 MBq 68Ga-TRAP-(RGD)3) were performed on a dedicated small animal PET before (day 0, baseline) and after (day 7, follow-up) a 1-week therapy with the VEGF antibody bevacizumab or placebo (imaging cohort n = 13; therapy n = 7, control n = 6)...
2016: PloS One
https://www.readbyqxmd.com/read/27987612/magnetic-resonance-venography-and-three-dimensional-image-fusion-guidance-provide-a-novel-paradigm-for-endovascular-recanalization-of-chronic-central-venous-occlusion
#7
Adeline Schwein, Tony Lu, Ponraj Chinnadurai, Danai Kitkungvan, Dipan J Shah, Nabil Chakfe, Alan B Lumsden, Jean Bismuth
OBJECTIVE: Endovascular recanalization is considered first-line therapy for chronic central venous occlusion (CVO). Unlike arteries, in which landmarks such as wall calcifications provide indirect guidance for endovascular navigation, sclerotic veins without known vascular branching patterns impose significant challenges. Therefore, safe wire access through such chronic lesions mostly relies on intuition and experience. Studies have shown that magnetic resonance venography (MRV) can be performed safely in these patients, and the boundaries of occluded veins may be visualized on specific MRV sequences...
January 2017: Journal of Vascular Surgery. Venous and Lymphatic Disorders
https://www.readbyqxmd.com/read/27941372/early-and-delayed-18f-fch-pet-ct-imaging-in-parathyroid-adenomas
#8
Cecilia Vellani, Marina Hodolič, Spyridon Chytiris, Giuseppe Trifirò, Domenico Rubello, Patrick M Colletti
Preoperative localization with Tc-sestaMIBI or ultrasound is a common prerequisite for successful minimally invasive parathyroid adenoma (PA) surgery. SPECT/CT with Tc-sestaMIBI and PET/CT with F-FCH offer the possibility of attenuation correction and coregistration of functional and anatomical images providing more accurate PA localization. F-FCH PET/CT is used predominantly in patients with prostate cancer and is under investigation in PA. We report the case of a 43-year-old man with early FCH uptake in a cystic PA with delayed washout at 60 minutes...
December 9, 2016: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/27910487/combined-neutron-and-x-ray-imaging-at-the-national-ignition-facility-invited
#9
C R Danly, K Christensen, V E Fatherley, D N Fittinghoff, G P Grim, R Hibbard, N Izumi, D Jedlovec, F E Merrill, D W Schmidt, R A Simpson, K Skulina, P L Volegov, C H Wilde
X-ray and neutrons are commonly used to image inertial confinement fusion implosions, providing key diagnostic information on the fuel assembly of burning deuterium-tritium (DT) fuel. The x-ray and neutron data provided are complementary as the production of neutrons and x-rays occurs from different physical processes, but typically these two images are collected from different views with no opportunity for co-registration of the two images. Neutrons are produced where the DT fusion fuel is burning; X-rays are produced in regions corresponding to high temperatures...
November 2016: Review of Scientific Instruments
https://www.readbyqxmd.com/read/27903441/optimising-experimental-design-for-meg-resting-state-functional-connectivity-measurement
#10
Lucrezia Liuzzi, Lauren E Gascoyne, Prejaas K Tewarie, Eleanor L Barratt, Elena Boto, Matthew J Brookes
The study of functional connectivity using magnetoencephalography (MEG) is an expanding area of neuroimaging, and adds an extra dimension to the more common assessments made using fMRI. The importance of such metrics is growing, with recent demonstrations of their utility in clinical research, however previous reports suggest that whilst group level resting state connectivity is robust, single session recordings lack repeatability. Such robustness is critical if MEG measures in individual subjects are to prove clinically valuable...
November 26, 2016: NeuroImage
https://www.readbyqxmd.com/read/27903187/stereotactic-diffusion-tensor-imaging-tractography-for-gamma-knife-radiosurgery
#11
Cormac G Gavin, H Ian Sabin
OBJECTIVE The integration of modern neuroimaging into treatment planning has increased the therapeutic potential and safety of stereotactic radiosurgery. The authors report their method of integrating stereotactic diffusion tensor imaging (DTI) tractography into conventional treatment planning for Gamma Knife radiosurgery (GKRS). The aim of this study was to demonstrate the feasibility of this technique and to address some of the technical limitations of previously reported techniques. METHODS Twenty patients who underwent GKRS composed the study cohort...
December 2016: Journal of Neurosurgery
https://www.readbyqxmd.com/read/27889345/histopathological-differential-diagnosis-of%C3%A2-optical-coherence-tomographic-image%C3%A2-interpretation-after-stenting
#12
Christoph Lutter, Hiroyoshi Mori, Kazuyuki Yahagi, Elena Ladich, Michael Joner, Robert Kutys, David Fowler, Maria Romero, Jagat Narula, Renu Virmani, Aloke V Finn
OBJECTIVES: The aim of this study was to identify histological features that correlate with terms commonly used to describe optical coherence tomographic (OCT) and optical frequency-domain imaging (OFDI) images of stented vessels, by means of a histopathological validation study using stented human coronary arteries. BACKGROUND: OCT imaging and OFDI are used to evaluate vascular responses to stent implantation. Descriptive terms such as "peristrut low attenuation" and "heterogeneous" have been used to describe neointimal characteristics that may have clinical relevance...
December 26, 2016: JACC. Cardiovascular Interventions
https://www.readbyqxmd.com/read/27879526/diagnostic-computed-tomography-coregistration-with-in-111-dtpa-octreotide-single-photon-emission-tomography-low-dose-computed-tomography
#13
Sagi Tshori, Moshe Bocher, Bella Yuzefovich, Rina Rubinstein, David J Gross, Merav Fraenkel, Yodphat Krausz
OBJECTIVES: In-111-DTPA-octreotide (OctreoScan) is still pivotal for neuroendocrine tumor imaging, despite the introduction of Ga-68-octreotide tracers. Low-dose computed tomography (LDCT) assists in the localization of SPECT findings but often results in uncertain interpretation. This retrospective study evaluates the impact of coregistration of In-111-DTPA-octreotide SPECT/LDCT with diagnostic CT on interpretation. METHODS: Thirty-five consecutive studies, in which coregistration was performed because of uncertain interpretation, were evaluated...
December 23, 2016: Journal of Computer Assisted Tomography
https://www.readbyqxmd.com/read/27770473/single-shot-spiral-imaging-enabled-by-an-expanded-encoding-model-demonstration-in-diffusion-mri
#14
Bertram J Wilm, Christoph Barmet, Simon Gross, Lars Kasper, S Johanna Vannesjo, Max Haeberlin, Benjamin E Dietrich, David O Brunner, Thomas Schmid, Klaas P Pruessmann
PURPOSE: The purpose of this work was to improve the quality of single-shot spiral MRI and demonstrate its application for diffusion-weighted imaging. METHODS: Image formation is based on an expanded encoding model that accounts for dynamic magnetic fields up to third order in space, nonuniform static B0 , and coil sensitivity encoding. The encoding model is determined by B0 mapping, sensitivity mapping, and concurrent field monitoring. Reconstruction is performed by iterative inversion of the expanded signal equations...
January 2017: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/27732160/chronic-obstructive-pulmonary-disease-lobar-analysis-with-hyperpolarized-129-xe-mr-imaging
#15
Tahreema N Matin, Najib Rahman, Annabel H Nickol, Mitchell Chen, Xiaojun Xu, Neil J Stewart, Tom Doel, Vicente Grau, James M Wild, Fergus V Gleeson
Purpose To compare lobar ventilation and apparent diffusion coefficient (ADC) values obtained with hyperpolarized xenon 129 ((129)Xe) magnetic resonance (MR) imaging to quantitative computed tomography (CT) metrics on a lobar basis and pulmonary function test (PFT) results on a whole-lung basis in patients with chronic obstructive pulmonary disease (COPD). Materials and Methods The study was approved by the National Research Ethics Service Committee; written informed consent was obtained from all patients. Twenty-two patients with COPD (Global Initiative for Chronic Obstructive Lung Disease stage II-IV) underwent hyperpolarized (129)Xe MR imaging at 1...
October 12, 2016: Radiology
https://www.readbyqxmd.com/read/27726412/predicting-glioblastoma-recurrence-by-early-changes-in-the-apparent-diffusion-coefficient-value-and-signal-intensity-on-flair-images
#16
Peter D Chang, Daniel S Chow, Peter H Yang, Christopher G Filippi, Angela Lignelli
OBJECTIVE: Recurrence of glioblastoma multiforme (GBM) arises from areas of microscopic tumor infiltration that have yet to disrupt the blood-brain barrier. We hypothesize that these microscopic foci of invasion cause subtle variations in the apparent diffusion coefficient (ADC) and FLAIR signal detectable with the use of computational big-data modeling. MATERIALS AND METHODS: Twenty-six patients with native GBM were studied immediately after undergoing gross total tumor resection...
January 2017: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/27661405/diffusion-weighted-imaging-using-a-readout-segmented-multishot-epi-sequence-at-3-t-distinguishes-between-morphologically-differentiated-and-undifferentiated-subtypes-of-thyroid-carcinoma-a-preliminary-study
#17
Stefan Schob, Peter Voigt, Lionel Bure, Hans-Jonas Meyer, Claudia Wickenhauser, Curd Behrmann, Annekathrin Höhn, Paul Kachel, Henning Dralle, Karl-Titus Hoffmann, Alexey Surov
BACKGROUND: Thyroid carcinomas represent the most frequent endocrine malignancies. Recent studies were able to distinguish malignant from benign nodules of the thyroid gland with diffusion-weighted imaging (DWI). Although this differentiation is undoubtedly helpful, presurgical discrimination between well-differentiated and undifferentiated carcinomas would be crucial to define the optimal treatment algorithm. Therefore, the aim of this study was to investigate if readout-segmented multishot echo planar DWI is able to differentiate between differentiated and undifferentiated subtypes of thyroid carcinomas...
October 2016: Translational Oncology
https://www.readbyqxmd.com/read/27637922/intraparenchymal-hyperattenuations-on-flat-panel-ct-directly-after-mechanical-thrombectomy-are-restricted-to-the-initial-infarct-core-on-diffusion-weighted-imaging
#18
Tanja Schneider, Tobias Mahraun, Julian Schroeder, Andreas Frölich, Philip Hoelter, Marlies Wagner, Jean Darcourt, Christophe Cognard, Alain Bonafé, Jens Fiehler, Susanne Siemonsen, Jan-Hendrik Buhk
PURPOSE: The presence of intraparenchymal hyperattenuations (IPH) on flat-panel computed tomography (FP-CT) after endovascular recanalization in stroke patients is a common phenomenon. They are thought to occur in ischemic areas with breakdown of the blood-brain barrier but previous studies that investigated a mutual interaction are scarce. We aimed to assess the relationship of IPH localization with prethrombectomy diffusion-weighted imaging (DWI) lesions. METHODS: This retrospective multicenter study included 27 acute stroke patients who underwent DWI prior to FP-CT following mechanical thrombectomy...
September 16, 2016: Clinical Neuroradiology
https://www.readbyqxmd.com/read/27611116/emotional-eating-and-in-vivo-norepinephrine-transporter-availability-in-obesity-a-11-c-mrb-pet-pilot-study
#19
A Bresch, M Rullmann, J Luthardt, G A Becker, G Reissig, M Patt, Y-S Ding, A Hilbert, O Sabri, S Hesse
OBJECTIVE: Emotional eating (EE) has been linked to norepinephrine dysfunction. Therefore, we aimed to investigate the relationship between EE and norepinephrine transporter (NET) availability. METHOD: Ten severely obese individuals (body mass index (BMI) 42.4 ± 3.7 kg/m(2) ) and ten non-obese, healthy controls (BMI 23.9 ± 2.5 kg/m(2) ) matched for age and sex were studied using (S,S)-[(11) C]-O-methylreboxetine ([(11) C]MRB) positron emission tomography (PET)...
September 9, 2016: International Journal of Eating Disorders
https://www.readbyqxmd.com/read/27610248/neuromuscular-plasticity-disentangling-stable-and-variable-motor-maps-in-the-human-sensorimotor-cortex
#20
Dominic Kraus, Alireza Gharabaghi
Motor maps acquired with transcranial magnetic stimulation (TMS) are evolving as a biomarker for monitoring disease progression or the effects of therapeutic interventions. High test-retest reliability of this technique for long observation periods is therefore required to differentiate daily or weekly fluctuations from stable plastic reorganization of corticospinal connectivity. In this study, a novel projection, interpolation, and coregistration technique, which considers the individual gyral anatomy, was applied in healthy subjects for biweekly acquired TMS motor maps over a period of twelve weeks...
2016: Neural Plasticity
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