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https://www.readbyqxmd.com/read/29717792/systematic-review-on-the-characterization-of-chronic-traumatic-encephalopathy-by-mri-and-mrs
#1
Rahel Ruprecht, Eva Scheurer, Claudia Lenz
BACKGROUND: Chronic traumatic encephalopathy (CTE) is a neurodegenerative disease that is found in people who have suffered from chronic traumatic brain injury (TBI). Up to now, diagnosis of CTE could only be made based on postmortem histopathological examinations. The application of MR techniques might offer a promising possibility for in vivo diagnoses. PURPOSE/HYPOTHESIS: To provide a critical systematic review of the characterization of chronic TBI and CTE by considering the range of MR techniques...
May 2, 2018: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/29704039/correction-to-18-f-fdg-pet-in-drug-resistant-epilepsy-due-to-focal-cortical-dysplasia-type-2-additional-value-of-electroclinical-data-and-coregistration-with-mri
#2
Serge Desarnaud, Charles Mellerio, Franck Semah, Agathe Laurent, Elisabeth Landre, Bertrand Devaux, Catherine Chiron, Vincent Lebon, Francine Chassoux
The original version of this article has added numbers in the text which are unnecessary. Correct line should be: "We also performed PET/MRI based surgical resections in an increasing number of MRI negative/ doubtful cases with favourable outcome."
April 28, 2018: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/29629803/dynamic-ct-for-parathyroid-adenoma-detection-how-does-radiation-dose-compare-with-nuclear-medicine
#3
Caroline A Czarnecki, Paul F Einsiedel, Pramit M Phal, Julie A Miller, Meir Lichtenstein, Damien L Stella
OBJECTIVE: Dynamic CT is increasingly used for preoperative localization of parathyroid adenomas, but concerns remain about the radiation effective dose of CT compared with that of 99m Tc-sestamibi scintigraphy. The purpose of this study was to compare the radiation dose delivered by three-phase dynamic CT with that delivered by 99m Tc-sestamibi SPECT/CT performed in accordance with our current protocols and to assess the possible reduction in effective dose achieved by decreasing the scan length (i...
April 9, 2018: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/29603482/3d-image-fusion-of-whole-heart-dynamic-cardiac-mr-perfusion-and-late-gadolinium-enhancement-intuitive-delineation-of-myocardial-hypoperfusion-and-scar
#4
Jochen von Spiczak, Manoj Mannil, Sebastian Kozerke, Hatem Alkadhi, Robert Manka
BACKGROUND: Since patients with myocardial hypoperfusion due to coronary artery disease (CAD) with preserved viability are known to benefit from revascularization, accurate differentiation of hypoperfusion from scar is desirable. PURPOSE: To develop a framework for 3D fusion of whole-heart dynamic cardiac MR perfusion and late gadolinium enhancement (LGE) to delineate stress-induced myocardial hypoperfusion and scar. STUDY TYPE: Prospective feasibility study...
March 30, 2018: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/29601885/an-image-registration-protocol-to-integrate-electrophysiology-mri-and-neuropathology-data-in-epileptic-patients-explored-with-intracerebral-electrodes
#5
Ileana Zucca, Gloria Milesi, Francesco Padelli, Laura Rossini, Francesca Gozzo, Matteo Figini, Andrea Barbaglia, Francesco Cardinale, Laura Tassi, Maria Grazia Bruzzone, Roberto Spreafico, Rita Garbelli
BACKGROUND: Several attempts have been made to coregister in vivo MRI with the histopathology of surgical samples, aiming to validate new MRI biomarkers and improve the detection of epileptogenic lesions. As a further implementation, we propose a method to reconstruct the anatomical localization of the intracerebral electrodes on the histological sections, developing a coregistration protocol to match the in vivo MRI onto the ex vivo MRI obtained from the surgical specimen. NEW METHOD: Since the ex vivo MRI is natively in geometrical correspondence with histology slices, the goal of the coregistration process is to compute the transform function mapping the clinical MRI space to the ex vivo MRI...
March 27, 2018: Journal of Neuroscience Methods
https://www.readbyqxmd.com/read/29594410/-18-f-fdg-pet-in-drug-resistant-epilepsy-due-to-focal-cortical-dysplasia-type-2-additional-value-of-electroclinical-data-and-coregistration-with-mri
#6
Serge Desarnaud, Charles Mellerio, Franck Semah, Agathe Laurent, Elisabeth Landre, Bertrand Devaux, Catherine Chiron, Vincent Lebon, Francine Chassoux
PURPOSE: To assess the localizing value of18 F-FDG PET in patients operated on for drug-resistant epilepsy due to focal cortical dysplasia type 2 (FCD2 ). METHODS: We analysed18 F-FDG PET scans from 103 consecutive patients (52 males, 7-65 years old) with histologically proven FCD2 . PET and MRI data were first reviewed by visual analysis blinded to clinical information and FCD2 location. The additional value of electroclinical data and PET/MRI coregistration was assessed by comparison with pathological results and surgical outcomes...
March 29, 2018: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/29507209/linking-imaging-to-omics-utilizing-image-guided-tissue-extraction
#7
Jonathan A Disselhorst, Marcel A Krueger, S M Minhaz Ud-Dean, Ilja Bezrukov, Mohamed A Jarboui, Christoph Trautwein, Andreas Traube, Christian Spindler, Jonathan M Cotton, Dieter Leibfritz, Bernd J Pichler
Phenotypic heterogeneity is commonly observed in diseased tissue, specifically in tumors. Multimodal imaging technologies can reveal tissue heterogeneity noninvasively in vivo, enabling imaging-based profiling of receptors, metabolism, morphology, or function on a macroscopic scale. In contrast, in vitro multiomics, immunohistochemistry, or histology techniques accurately characterize these heterogeneities in the cellular and subcellular scales in a more comprehensive but ex vivo manner. The complementary in vivo and ex vivo information would provide an enormous potential to better characterize a disease...
March 27, 2018: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29497357/inter-subject-registration-of-functional-images-do-we-need-anatomical-images
#8
Elvis Dohmatob, Gael Varoquaux, Bertrand Thirion
In Echo-Planar Imaging (EPI)-based Magnetic Resonance Imaging (MRI), inter-subject registration typically uses the subject's T1-weighted (T1w) anatomical image to learn deformations of the subject's brain onto a template. The estimated deformation fields are then applied to the subject's EPI scans (functional or diffusion-weighted images) to warp the latter to a template space. Historically, such indirect T1w-based registration was motivated by the lack of clear anatomical details in low-resolution EPI images: a direct registration of the EPI scans to template space would be futile...
2018: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/29487884/-ex-vivo-study-in-nephroureterectomy-specimens-defining-the-role-of-3-d-upper-urinary-tract-visualization-using-optical-coherence-tomography-and-endoluminal-ultrasound
#9
Mieke T J Bus, Paul Cernohorsky, Daniel M de Bruin, Sybren L Meijer, Geert J Streekstra, Dirk J Faber, Guido M Kamphuis, Patricia J Zondervan, Marcel van Herk, Maria P Laguna Pes, Maik J Grundeken, Martin J Brandt, Theo M de Reijke, Jean J M C H de la Rosette, Ton G van Leeuwen
Minimal invasive endoscopic treatment for upper urinary tract urothelial carcinoma (UUT-UC) is advocated in patients with low-risk disease and limited tumor volume. Diagnostic ureterorenoscopy combined with biopsy is the diagnostic standard. This study aims to evaluate two alternative diagnostic techniques for UUT-UC: optical coherence tomography (OCT) and endoluminal ultrasound (ELUS). Following nephroureterectomy, OCT, ELUS, and computed tomography (CT) were performed of the complete nephroureterectomy specimen...
January 2018: Journal of Medical Imaging
https://www.readbyqxmd.com/read/29480813/quality-assessment-of-meg-to-mri-coregistrations
#10
Hermann Sonntag, Jens Haueisen, Burkhard Maess
For high precision in source reconstruction of magnetoencephalography (MEG) or electroencephalography data, high accuracy of the coregistration of sources and sensors is mandatory. Usually, the source space is derived from magnetic resonance imaging (MRI). In most cases, however, no quality assessment is reported for sensor-to-MRI coregistrations. If any, typically root mean squares (RMS) of point residuals are provided. It has been shown, however, that RMS of residuals do not correlate with coregistration errors...
March 22, 2018: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/29392175/correlated-heterospectral-lipidomics-for-biomolecular-profiling-of-remyelination-in-multiple-sclerosis
#11
Mads S Bergholt, Andrea Serio, James S McKenzie, Amanda Boyd, Renata F Soares, Jocelyn Tillner, Ciro Chiappini, Vincen Wu, Andreas Dannhorn, Zoltan Takats, Anna Williams, Molly M Stevens
Analyzing lipid composition and distribution within the brain is important to study white matter pathologies that present focal demyelination lesions, such as multiple sclerosis. Some lesions can endogenously re-form myelin sheaths. Therapies aim to enhance this repair process in order to reduce neurodegeneration and disability progression in patients. In this context, a lipidomic analysis providing both precise molecular classification and well-defined localization is crucial to detect changes in myelin lipid content...
January 24, 2018: ACS Central Science
https://www.readbyqxmd.com/read/29385722/automatic-coregistration-algorithm-to-remove-canopy-shaded-pixels-in-uav-borne-thermal-images-to-improve-the-estimation-of-crop-water-stress-index-of-a-drip-irrigated-cabernet-sauvignon-vineyard
#12
Tomas Poblete, Samuel Ortega-Farías, Dongryeol Ryu
Water stress caused by water scarcity has a negative impact on the wine industry. Several strategies have been implemented for optimizing water application in vineyards. In this regard, midday stem water potential (SWP) and thermal infrared (TIR) imaging for crop water stress index (CWSI) have been used to assess plant water stress on a vine-by-vine basis without considering the spatial variability. Unmanned Aerial Vehicle (UAV)-borne TIR images are used to assess the canopy temperature variability within vineyards that can be related to the vine water status...
January 30, 2018: Sensors
https://www.readbyqxmd.com/read/29371120/coregistration-of-preoperative-mri-with-ex-vivo-mesorectal-pathology-specimens-to-spatially-map-post-treatment-changes-in-rectal-cancer-onto-in-vivo-imaging-preliminary-findings
#13
Jacob Antunes, Satish Viswanath, Justin T Brady, Benjamin Crawshaw, Pablo Ros, Scott Steele, Conor P Delaney, Raj Paspulati, Joseph Willis, Anant Madabhushi
RATIONALE AND OBJECTIVES: The objective of this study was to develop and quantitatively evaluate a radiology-pathology fusion method for spatially mapping tissue regions corresponding to different chemoradiation therapy-related effects from surgically excised whole-mount rectal cancer histopathology onto preoperative magnetic resonance imaging (MRI). MATERIALS AND METHODS: This study included six subjects with rectal cancer treated with chemoradiation therapy who were then imaged with a 3-T T2-weighted MRI sequence, before undergoing mesorectal excision surgery...
January 19, 2018: Academic Radiology
https://www.readbyqxmd.com/read/29364511/-18-f-ge180-positron-emission-tomographic-imaging-indicates-a-potential-double-hit-insult-in-the-intrahippocampal-kainate-mouse-model-of-temporal-lobe-epilepsy
#14
Mirjam Brackhan, Pablo Bascuñana, Tobias L Ross, Frank M Bengel, Jens P Bankstahl, Marion Bankstahl
OBJECTIVE: Accumulating evidence suggests that brain inflammation, elicited by epileptogenic insults, is involved in epilepsy development. Noninvasive nuclear imaging of brain inflammation in animal models of epileptogenesis represents a diagnostic in vivo approach with potential for direct translation into the clinic. Here, we investigated up-regulation of the translocator protein (TSPO) indicative of microglial activation by serial [18 F]GE180 positron emission tomographic (PET) imaging in a mouse model of temporal lobe epilepsy...
March 2018: Epilepsia
https://www.readbyqxmd.com/read/29361243/emphysematous-and-nonemphysematous-gas-trapping-in-chronic-obstructive-pulmonary-disease-quantitative-ct-findings-and-pulmonary-function
#15
Mariaelena Occhipinti, Matteo Paoletti, Francesca Bigazzi, Gianna Camiciottoli, Riccardo Inchingolo, Anna Rita Larici, Massimo Pistolesi
Purpose To identify a prevalent computed tomography (CT) subtype in patients with chronic obstructive pulmonary disease (COPD) by separating emphysematous from nonemphysematous contributions to total gas trapping and to attempt to predict and grade the emphysematous gas trapping by using clinical and functional data. Materials and Methods Two-hundred and two consecutive eligible patients (159 men and 43 women; mean age, 70 years [age range, 41-85 years]) were prospectively studied. Pulmonary function and CT data were acquired by pulmonologists and radiologists...
May 2018: Radiology
https://www.readbyqxmd.com/read/29360694/attenuation-correction-in-myocardial-perfusion-imaging-affects-the-assessment-of-infarct-size-in-women-with-previous-inferior-infarct
#16
Alessia Peli, Luca Camoni, Valentina Zilioli, Rexhep Durmo, Mattia Bonacina, Francesco Bertagna, Barbara Paghera, Raffaele Giubbini
BACKGROUND: Myocardial perfusion imaging is a well-established diagnostic tool in patients with known or suspected coronary artery disease. Numerous clinical trials have shown that attenuation correction (AC) in single photon emission computed tomography (SPECT) improves the diagnostic accuracy of myocardial perfusion imaging over non-AC SPECT, differentiating between scar and attenuation artifacts. We have previously shown that attenuation artifacts produce an overestimation of the size of inferior infarcts in the male population...
April 2018: Nuclear Medicine Communications
https://www.readbyqxmd.com/read/29347968/-18-f-fdg-pet-ct-and-diffusion-weighted-mri-for-monitoring-a-braf-and-cdk-4-6-inhibitor-combination-therapy-in-a-murine-model-of-human-melanoma
#17
Ralf S Eschbach, Philipp M Kazmierczak, Maurice M Heimer, Andrei Todica, Heidrun Hirner-Eppeneder, Moritz J Schneider, Georg Keinrath, Olga Solyanik, Jessica Olivier, Wolfgang G Kunz, Maximilian F Reiser, Peter Bartenstein, Jens Ricke, Clemens C Cyran
BACKGROUND: The purpose of the study was to investigate a novel BRAF and CDK 4/6 inhibitor combination therapy in a murine model of BRAF-V600-mutant human melanoma monitored by 18 F-FDG-PET/CT and diffusion-weighted MRI (DW-MRI). METHODS: Human BRAF-V600-mutant melanoma (A375) xenograft-bearing balb/c nude mice (n = 21) were imaged by 18 F-FDG-PET/CT and DW-MRI before (day 0) and after (day 7) a 1-week BRAF and CDK 4/6 inhibitor combination therapy (n = 12; dabrafenib, 20 mg/kg/d; ribociclib, 100 mg/kg/d) or placebo (n = 9)...
January 18, 2018: Cancer Imaging: the Official Publication of the International Cancer Imaging Society
https://www.readbyqxmd.com/read/29331053/renal-flow-and-microstructure-anisotropy-refmap-mri-in-normal-and-peritumoral-renal-tissue
#18
Andrea L Liu, Artem Mikheev, Henry Rusinek, William C Huang, James S Wysock, James S Babb, Thorsten Feiweier, David Stoffel, Hersh Chandarana, Eric E Sigmund
BACKGROUND: Diffusion-weighted imaging (DWI) provides insight into the pathophysiology underlying renal dysfunction. Variants of DWI include intravoxel incoherent motion (IVIM), which differentiates between microstructural diffusion and vascular or tubular flow, and diffusion tensor imaging (DTI), which quantifies diffusion directionality. PURPOSE: To investigate the reproducibility of joint IVIM-DTI and compare controls to presurgical renal mass patients. STUDY TYPE: Prospective cross-sectional...
January 13, 2018: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/29324929/our-solution-for-fusion-of-simultaneusly-acquired-whole-body-scintigrams-and-optical-images-as-usesful-tool-in-clinical-practice-in-patients-with-differentiated-thyroid-carcinomas-after-radioiodine-therapy-a-useful-tool-in-clinical-practice
#19
Milovan Matovic, Milica Jankovic, Marko Barjaktarovic, Marija Jeremic
OBJECTIVE: After radioiodine therapy of differentiated thyroid cancer (DTC) patients, whole body scintigraphy (WBS) is standard procedure before releasing the patient from the hospital. A common problem is the precise localization of regions where the iod-avide tissue is located. Sometimes is practically impossible to perform precise topographic localization of such regions. METHOD: In order to face this problem, we have developed a low-cost Vision-Fusion system for web-camera image acquisition simultaneously with routine scintigraphic whole body acquisition including the algorithm for fusion of images given from both cameras...
September 2017: Hellenic Journal of Nuclear Medicine
https://www.readbyqxmd.com/read/29317185/cortical-inhibition-assessed-using-paired-pulse-tms-eeg-is-increased-in-older-adults
#20
George M Opie, Simranjit K Sidhu, Nigel C Rogasch, Michael C Ridding, John G Semmler
BACKGROUND: Alterations in inhibitory processes mediated by gamma-aminobutyric acid type B (GABAB ) receptors may contribute to age-related functional impairments. However, investigation of these circuits using conventional paired-pulse transcranial magnetic stimulation (TMS) at long interstimulus intervals (∼100-200ms) have produced conflicting results in older adults, possibly due to the indirect nature of the TMS motor evoked potential (MEP). OBJECTIVE: To utilise electroencephalography and TMS coregistration (TMS-EEG) to more directly assess age-related changes in GABAB -mediated long-interval intracortical inhibition (LICI)...
December 30, 2017: Brain Stimulation
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