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"neural mobilization"

Aline Carolina Giardini, Fabio Martinez Dos Santos, Joyce Teixeira da Silva, Mara Evany de Oliveira, Daniel Oliveira Martins, Marucia Chacur
Background. Glial cells are implicated in the development of chronic pain and brain-derived neurotropic factor (BDNF) released from activated microglia contributes to the nociceptive transmission. Neural mobilization (NM) technique is a method clinically effective in reducing pain sensitivity. Here we examined the involvement of glial cells and BDNF expression in the thalamus and midbrain after NM treatment in rats with chronic constriction injury (CCI). CCI was induced and rats were subsequently submitted to 10 sessions of NM, every other day, beginning 14 days after CCI...
2017: Pain Research & Management: the Journal of the Canadian Pain Society
David Rodríguez-Sanz, César Calvo-Lobo, Francisco Unda-Solano, Irene Sanz-Corbalán, Carlos Romero-Morales, Daniel López-López
Background.:  Cervicobrachial pain (CP) is a high-incidence and prevalent condition. Cervical lateral glide (CLG) is a firstline treatment of CP. There is a current lack of enough high-quality randomized controlled double-blind clinical trials that measure the effectiveness of neural tissue mobilization techniques such as the CLG and its specific effect over CP. Objectives.:  The aim of the present study was to assess the effect of CLG neural mobilization in treating subjects who suffer from CP, compared with the complete absence of treatment...
March 13, 2017: Pain Medicine: the Official Journal of the American Academy of Pain Medicine
Amelie T van der Ven, Julius C Pape, Dirk Hermann, Robert Schloesser, Just Genius, Nadine Fischer, Rainald Mößner, Norbert Scherbaum, Jens Wiltfang, Dan Rujescu, Jens Benninghoff
An interest in neurogenesis in the adult human brain as a relevant and targetable process has emerged as a potential treatment option for Alzheimer's disease and other neurodegenerative conditions. The aim of this study was to investigate the effects of tetramethylthionine chloride (methylene blue, MB) on properties of adult murine neural stem cells. Based on recent clinical studies, MB has increasingly been discussed as a potential treatment for Alzheimer's disease. While no differences in the proliferative capacity were identified, a general potential of MB in modulating the migratory capacity of adult neural stem cells was indicated in a cell mobility assay...
2017: Journal of Alzheimer's Disease: JAD
Irene de la Rosa Díaz, María Torres Lacomba, Ester Cerezo Téllez, Cristina Díaz Del Campo Gómez-Rico, Carlos Gutiérrez Ortega
OBJECTIVE: The aim of this study was to assess the methods to conduct a substantive clinical trial to evaluate the effects of accessory joint mobilization (AJM) vs neural mobilization (NM) techniques for shoulder motion restriction after breast cancer surgery. METHODS: This pilot study was a prospective randomized and double-blind clinical trial in which 18 women who underwent unilateral breast cancer surgery and axillary lymph node dissection participated. The study was conducted at the Women's Health Research Group at the Physical Therapy Department of Alcalá University, Madrid, Spain...
March 2017: Journal of Chiropractic Medicine
Ruth Ballestero-Pérez, Gustavo Plaza-Manzano, Alicia Urraca-Gesto, Flor Romo-Romo, María de Los Ángeles Atín-Arratibel, Daniel Pecos-Martín, Tomás Gallego-Izquierdo, Natalia Romero-Franco
OBJECTIVE: The objective of this study was to review the literature regarding the effectiveness of neural gliding exercises for the management of carpal tunnel syndrome (CTS). METHODS: A computer-based search was completed through May 2014 in PubMed, Physiotherapy Evidence Database (PEDro), Web of Knowledge, Cochrane Plus, and CINAHL. The following key words were included: nerve tissue, gliding, exercises, carpal tunnel syndrome, neural mobilization, and neurodynamic mobilization...
January 2017: Journal of Manipulative and Physiological Therapeutics
Alejandro Ferragut-Garcías, Gustavo Plaza-Manzano, Cleofás Rodríguez-Blanco, Olga Velasco-Roldán, Daniel Pecos-Martín, Jesús Oliva-Pascual-Vaca, Bartomeu Llabrés-Bennasar, Ángel Oliva-Pascual-Vaca
OBJECTIVE: To evaluate the effects of a protocol involving soft tissue techniques and/or neural mobilization techniques in the management of patients with frequent episodic tension-type headache (FETTH) and those with chronic tension-type headache (CTTH). DESIGN: Randomized, double-blind, placebo-controlled before and after trial. SETTING: Rehabilitation area of the local hospital and a private physiotherapy center. PARTICIPANTS: Patients (N=97; 78 women, 19 men) diagnosed with FETTH or CTTH were randomly assigned to groups A, B, C, or D...
February 2017: Archives of Physical Medicine and Rehabilitation
Monara Kedma Nunes, Gabrielly Fontenele Dos Santos, Diandra Caroline Martins E Silva, Ana Cláudia Mota de Freitas, Isadora Ferreira Henriques, Peterson Marco Andrade, Dionis de Castro Machado, Silmar Teixeira, Marco Orsini Neves, Gildário Dias, Fernando Silva-Júnior, Victor Hugo Bastos
[Purpose] This study analyzed the acute effects of infrared and neural mobilization on the median nerve on the range of elbow extension of the dominant limb. [Subjects and Methods] Forty participants from university, neurologically asymptomatic, 12 males and 28 females (22.8 ± 1.9 years), were randomly divided into four groups: Group 1 (control) rested for 25 minutes in the supine position; Group 2 received the specific neural mobilization for the median nerve; Group 3 received an application of infrared for 15 minutes on the forearm; Group 4 received the same application of infrared followed by neural mobilization...
June 2016: Journal of Physical Therapy Science
Myoung-Kwon Kim, Hyun-Gyu Cha, Sang Gu Ji
[Purpose] The purpose of this study was to determine the effects of an upper extremity neural mobilization technique on delayed onset muscle soreness. [Subjects] Forty-five healthy subjects were randomly assigned to two groups: a nerve mobilization group (experimental) and a control group. [Methods] The subjects of the experimental group were administered a median nerve mobilization technique and ultrasound for the biceps brachii muscle. The subjects in the control group were only administered ultrasound for the biceps brachii muscle...
March 2016: Journal of Physical Therapy Science
Kerry K Gilbert, C Roger James, Gail Apte, Cynthia Brown, Phillip S Sizer, Jean-Michel Brismée, Michael P Smith
BACKGROUND AND PURPOSE: Neural mobilization techniques are used clinically to treat neuropathic pain and dysfunction. While selected studies report efficacy of these techniques, the mechanisms of benefit are speculative. The purpose of this study was to evaluate the effects of in vitro simulated stretch/relax neural mobilization cycles on fluid dispersion within sections of unembalmed cadaveric peripheral nerve tissue. METHODS: Bilateral sciatic nerve sections were harvested from six cadavers...
September 2015: Journal of Manual & Manipulative Therapy
Yunfeng Su, Edwin Choon Wyn Lim
OBJECTIVES: In nerve-related chronic musculoskeletal (MS) disorders, neural tissue management is used to relieve pain by balancing the relative movement of neural tissues and their surrounding tissues. To date, there has not been any review evaluating the magnitude of this treatment effect in nerve-related chronic MS pain. The aim of this review was to compare pain and disability in individuals with nerve-related chronic MS pain who were treated with neural tissue management with those who received minimal or other treatment approaches...
November 2016: Clinical Journal of Pain
C Casanova-García, S Lerma Lara, M Pérez Ruiz, D Ruano Domínguez, E Santana Sosa
Neuropathic pain (NP) associated with childhood cancer is currently a difficult problem to control. It is treated with drugs that not only fail to provide the expected improvements, but which also have side effects. Therefore, the main aim of this pilot study is to assess whether non-pharmacological treatments, Graded Motor Imagery (GMI) and Neural Mobilization (NM), have a positive effect on this pain, thus improving the associated comorbid factors and, consequently, the quality of life of the children. In an n = 6, the results after 4 weeks of treatment show a 10-point improvement in the pain threshold and a 3...
December 2015: Medical Hypotheses
Annalie Basson, Benita Olivier, Richard Ellis, Michel Coppieters, Aimee Stewart, Witness Mudzi
REVIEW QUESTION/OBJECTIVE: The objective of this review is to identify the effectiveness of neural mobilization techniques in various neuro-musculoskeletal conditions. Outcomes will be analyzed in terms of subgroups such as low back pain, cervico-brachial pain and carpal tunnel syndrome. BACKGROUND: Musculoskeletal disorders were ranked as the second largest contributor to disability worldwide in a study on the global burden of disease. Low back pain and neck pain contributed to 70% of disability in this comprehensive population-based study...
January 2015: JBI Database of Systematic Reviews and Implementation Reports
Simone Horwitz, Aimee Stewart
PURPOSE: To determine whether an association between cervical dysfunction and perimenstrual migraines exists. METHODS: Forty perimenstrual migraine sufferers and 46 controls were compared. Information on the participants' ages and perceptions of neck pain and stiffness were solicited. The blinded physical examination of the cervical area consisted of postural, range of motion, muscle strength, muscle length, trigger point, neural mobility, and segmental cervical joint movement assessment...
2015: Physiotherapy Canada. Physiothérapie Canada
Federica Ginanneschi, David Cioncoloni, Jacopo Bigliazzi, Marco Bonifazi, Cosimo Lorè, Alessandro Rossi
Increased mechanosensitivity of the median nerve in carpal tunnel syndrome (CTS) has been demonstrated during upper limb tension test 1 (ULTT1) when the nerve is passively elongated. However, the neurophysiological changes of the sensory axons during stressing activities are unknown. The aim of present study was to verify possible changes in the excitability of median nerve afferent axons following nerve stress in elongation, in subjects with and without CTS. Eight CTS hands and eight controls were selected...
September 2015: Neurological Sciences
Michalis A Efstathiou, Manos Stefanakis, Christos Savva, Giannis Giakas
Spinal radiculopathy (SR) is a multifactorial nerve root injury that can result in significant pain, psychological stress and disability. It can occur at any level of the spinal column with the highest percentage in the lumbar spine. Amongst the various interventions that have been suggested, neural mobilization (NM) has been advocated as an effective treatment option. The purpose of this review is to (1) examine pathophysiological aspects of spinal roots and peripheral nerves, (2) analyze the proposed mechanisms of NM as treatment of injured nerve tissues and (3) critically review the existing research evidence for the efficacy of NM in patients with lumbar or cervical radiculopathy...
April 2015: Journal of Bodywork and Movement Therapies
Carlo Ammendolia, Ngai Chow
OBJECTIVE: The purpose of this preliminary study was to assess the effectiveness of a 6-week, nonsurgical, multimodal program that addresses the multifaceted aspects of neurogenic claudication. METHODS: In this retrospective study, 2 researchers independently extracted data from the medical records from January 2010 to April 2013 of consecutive eligible patients who had completed the 6-week Boot Camp Program. The program consisted of manual therapy twice per week (eg, soft tissue and neural mobilization, chiropractic spinal manipulation, lumbar flexion-distraction, and muscle stretching), structured home-based exercises, and instruction of self-management strategies...
March 2015: Journal of Manipulative and Physiological Therapeutics
Joyce Teixeira da Silva, Fabio Martinez Dos Santos, Aline Caroline Giardini, Daniel de Oliveira Martins, Mara Evany de Oliveira, Adriano Polican Ciena, Vanessa Pacciari Gutierrez, Ii-Sei Watanabe, Luiz Roberto G de Britto, Marucia Chacur
Neurotrophins are crucial in relation to axonal regrowth and remyelination following injury; and neural mobilization (NM) is a noninvasive therapy that clinically is effective in neuropathic pain treatment, but its mechanisms remains unclear. We examined the effects of NM on the regeneration of sciatic nerve after chronic constriction injury (CCI) in rats. The CCI was performed on adult male rats, submitted to 10 sessions of NM, starting 14 days after CCI. Then, the nerves were analyzed using transmission electron microscopy and western blot for neural growth factor (NGF) and myelin protein zero (MPZ)...
February 2015: Growth Factors
Sudarshan Anandkumar
This case report describes a 31-year-old male who presented with complaints of chronic pain in his right elbow. Detailed subjective examination revealed that the patient had searched Google for extensive online information relating to his pain, ultimately self-labeling with various diagnoses. After researching in YouTube, the patient self-treated with ice, exercises, neural mobilization, self-massage and taping, all resulting in a failed outcome. Clinical findings revealed trigger points in his right brachioradialis muscle with added symptoms of central pain...
March 2015: Physiotherapy Theory and Practice
Vanitha Arumugam, Senthil Selvam, Joy C MacDermid
STUDY DESIGN: Prospective Experimental Study. BACKGROUND: Computer users may be at risk of lateral elbow pain. It is theorized that adverse mechanical tension can arise in the radial nerve with sustained keyboarding due to sustained static work of the elbow extensor muscles. Neural mobilization has been suggested as a potential treatment. PURPOSE: The purpose of this study was to evaluate the effect of neural mobilization of the radial nerve on a single occasion in terms of its ability to reduce lateral elbow pain...
2014: Open Orthopaedics Journal
Ana Silva, André Manso, Ricardo Andrade, Vanessa Domingues, Maria Piedade Brandão, Anabela G Silva
BACKGROUND: Neural system mobilization is widely used in the treatment of several painful conditions. Data on nerve biomechanics is crucial to inform the design of mobilization exercises. Therefore, the aim of this review is to characterize normal nervous system biomechanics in terms of excursion and strain. METHODS: Studies were sought from Pubmed, Physiotherapy Evidence Database, Cochrane Library, Web of Science and Scielo. Two reviewers' screened titles and abstracts, assessed full reports for potentially eligible studies, extracted information on studies' characteristics and assessed its methodological quality...
September 2014: Clinical Biomechanics
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