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https://www.readbyqxmd.com/read/28076977/combining-microfractures-autologous-bone-graft-and-autologous-matrix-induced-chondrogenesis-for-the-treatment-of-juvenile-osteochondral-talar-lesions
#1
Riccardo D'Ambrosi, Camilla Maccario, Chiara Ursino, Nicola Serra, Federico Giuseppe Usuelli
BACKGROUND: The purpose of this study was to evaluate the clinical and radiologic outcomes of patients younger than 20 years, treated with the arthroscopic-talus autologous matrix-induced chondrogenesis (AT-AMIC) technique and autologous bone graft for osteochondral lesion of the talus (OLT). METHODS: Eleven patients under 20 years (range 13.3-20.0) underwent the AT-AMIC procedure and autologous bone graft for OLTs. Patients were evaluated preoperatively (T0) and at 6 (T1), 12 (T2), and 24 (T3) months postoperatively, using the American Orthopaedic Foot & Ankle Society Ankle and Hindfoot (AOFAS) score, the visual analog scale and the SF-12 respectively in its Mental and Physical Component Scores...
January 1, 2017: Foot & Ankle International
https://www.readbyqxmd.com/read/28070456/a-simple-rat-model-of-mild-traumatic-brain-injury-a-device-to-reproduce-anatomical-and-neurological-changes-of-mild-traumatic-brain-injury
#2
Ho Jeong Kim, Soo Jeong Han
Mild traumatic brain injury typically involves temporary impairment of neurological function. Previous studies used water pressure or rotational injury for designing the device to make a rat a mild traumatic brain injury model. The objective of this study was to make a simple model of causing mild traumatic brain injury in rats. The device consisted of a free-fall impactor that was targeted onto the rat skull. The weight (175 g) was freely dropped 30 cm to rat's skull bregma. We installed a safety device made of acrylic panel...
2017: PeerJ
https://www.readbyqxmd.com/read/28062970/good-prognosis-of-postpartum-lower-limb-sensorimotor-deficit-a-combined-clinical-electrophysiological-and-radiological-follow-up
#3
A Richard, G Vellieux, S Abbou, J L Benifla, P Lozeron, N Kubis
Postpartum lower limb motor and/or sensory deficit is an uncommon obstetrical complication. We aimed to identify its incidence, etiology, and precipitating factors, as well as the neurological prognosis by retrospectively analyzing the successive neurological evaluations, electrophysiological, and MRI data from all the consecutive patients with postpartum motor and/or sensory deficits of the lower limbs referred from the Lariboisière Obstetrical Department to the Lariboisière Neurophysiology Department, from January 2012 to June 2016, as well as data concerning labor and morphological characteristics of mother and baby...
January 6, 2017: Journal of Neurology
https://www.readbyqxmd.com/read/28061547/comparison-of-magnetic-resonance-imaging-and-stress-radiographs-in-the-evaluation-of-chronic-lateral-ankle-instability
#4
Scott Jolman, Justin Robbins, Laura Lewis, Melissa Wilkes, Paul Ryan
BACKGROUND: In patients who develop chronic ankle instability, clinicians often obtain magnetic resonance imaging (MRI) as part of the evaluation prior to operative referral. The purpose of this study was to analyze the diagnostic efficacy of MRI in the diagnosis of chronic lateral ankle instability. Our hypothesis was that magnetic resonance imaging would not be a specific diagnostic tool in the evaluation of chronic lateral ankle instability. MATERIALS AND METHODS: A retrospective chart review of 187 consecutive patients (190 ankles) was performed...
January 1, 2017: Foot & Ankle International
https://www.readbyqxmd.com/read/28050345/functional-mri-vs-navigated-tms-to-optimize-m1-seed-volume-delineation-for-dti-tractography-a-prospective-study-in-patients-with-brain-tumours-adjacent-to-the-corticospinal-tract
#5
Carolin Weiss Lucas, Irada Tursunova, Volker Neuschmelting, Charlotte Nettekoven, Ana-Maria Oros-Peusquens, Gabriele Stoffels, Andrea Maria Faymonville, Shah N Jon, Karl Josef Langen, Hannah Lockau, Roland Goldbrunner, Christian Grefkes
BACKGROUND: DTI-based tractography is an increasingly important tool for planning brain surgery in patients suffering from brain tumours. However, there is an ongoing debate which tracking approaches yield the most valid results. Especially the use of functional localizer data such as navigated transcranial magnetic stimulation (nTMS) or functional magnetic resonance imaging (fMRI) seem to improve fibre tracking data in conditions where anatomical landmarks are less informative due to tumour-induced distortions of the gyral anatomy...
2017: NeuroImage: Clinical
https://www.readbyqxmd.com/read/28033048/delayed-surgical-reconstruction-of-a-peroneal-tendon-rupture-in-an-accessory-os-peroneuma-rare-differential-diagnosis-in-chronic-ankle-pain
#6
Julia Evers, Dirk Wähnert, Niklas Grüneweller, Michael J Raschke, Sabine Ochman
A fracture of the os peroneum is a rare cause of ankle and foot pain and is often overlooked and not assumed. Only a few case reports have discussed the different etiologies, options for diagnosis, and therapeutic interventions for acute cases. We present a case of delayed diagnosis of an os peroneum fracture due to a distortion of the ankle that occurred during air sports. Initial diagnostic testing with magnetic resonance imaging demonstrated a rupture of the peroneus longus tendon with no pathologic abnormalities at the peroneus brevis tendon...
November 2016: Journal of the American Podiatric Medical Association
https://www.readbyqxmd.com/read/28018075/intraosseous-leiomyoma-of-the-calcaneum-an-unusual-bone-tumor-of-foot-and-review-of-literature
#7
Abhijeet Ashok Salunke, Pathik Chandrakant Vala, Harpreet Singh, Rohan Parwani, Sanjay Gandhi, Diva Shah
Leiomyoma is a benign tumor of smooth muscle origin and commonly diagnosed in the uterus, gastrointestinal tract, skin, and mucous membranes. To the best of our knowledge, the only reported intraosseous leiomyomas in extremities occurred in the proximal aspect and distal aspect of the femur, in the tibia, and in the ulna. We are not aware of any previous reports of intraosseous leiomyomas in the foot. The radiograph of the intraosseous leiomyoma shows unilocular or multilocular lytic lesion with sclerotic rim...
October 2016: Journal of Clinical Orthopaedics and Trauma
https://www.readbyqxmd.com/read/28003562/a-novel-diffusion-tensor-mri-approach-for-skeletal-muscle-fascicle-length-measurements
#8
Jos Oudeman, Valentina Mazzoli, Marco A Marra, Klaas Nicolay, Mario Maas, Nico Verdonschot, Andre M Sprengers, Aart J Nederveen, Gustav J Strijkers, Martijn Froeling
Musculoskeletal (dys-)function relies for a large part on muscle architecture which can be obtained using Diffusion-Tensor MRI (DT-MRI) and fiber tractography. However, reconstructed tracts often continue along the tendon or aponeurosis when using conventional methods, thus overestimating fascicle lengths. In this study, we propose a new method for semiautomatic segmentation of tendinous tissue using tract density (TD). We investigated the feasibility and repeatability of this method to quantify the mean fascicle length per muscle...
December 2016: Physiological Reports
https://www.readbyqxmd.com/read/28002688/ocrelizumab-versus-placebo-in-primary-progressive-multiple-sclerosis
#9
Xavier Montalban, Stephen L Hauser, Ludwig Kappos, Douglas L Arnold, Amit Bar-Or, Giancarlo Comi, Jérôme de Seze, Gavin Giovannoni, Hans-Peter Hartung, Bernhard Hemmer, Fred Lublin, Kottil W Rammohan, Krzysztof Selmaj, Anthony Traboulsee, Annette Sauter, Donna Masterman, Paulo Fontoura, Shibeshih Belachew, Hideki Garren, Nicole Mairon, Peter Chin, Jerry S Wolinsky
Background An evolving understanding of the immunopathogenesis of multiple sclerosis suggests that depleting B cells could be useful for treatment. We studied ocrelizumab, a humanized monoclonal antibody that selectively depletes CD20-expressing B cells, in the primary progressive form of the disease. Methods In this phase 3 trial, we randomly assigned 732 patients with primary progressive multiple sclerosis in a 2:1 ratio to receive intravenous ocrelizumab (600 mg) or placebo every 24 weeks for at least 120 weeks and until a prespecified number of confirmed disability progression events had occurred...
December 21, 2016: New England Journal of Medicine
https://www.readbyqxmd.com/read/27999984/is-there-an-added-value-of-t1-weighted-contrast-enhanced-fat-suppressed-spin-echo-mr-sequences-compared-to-stir-sequences-in-mri-of-the-foot-and-ankle
#10
Veronika Zubler, Marco Zanetti, Tobias J Dietrich, Norman Espinosa, Christian W Pfirrmann, Nadja Mamisch-Saupe
OBJECTIVES: To prospectively compare T1-weighted fat-suppressed spin-echo magnetic resonance (MR) sequences after gadolinium application (T1wGdFS) to STIR sequences in patients with acute and chronic foot pain. METHODS: In 51 patients referred for MRI of the foot and ankle, additional transverse and sagittal T1wGdFS sequences were obtained. Two sets of MR images (standard protocol with STIR or T1wGdFS) were analysed. Diagnosis, diagnostic confidence, and localization of the abnormality were noted...
December 20, 2016: European Radiology
https://www.readbyqxmd.com/read/27989351/occult-isolated-articular-branch-cyst-of-the-lateral-plantar-nerve
#11
Nikhil Prasad, Kimberly K Amrami, Kivanc Yangi, Robert J Spinner
We present the first known case of cyst fluid localized to an articular branch without involvement of the larger parent nerve. During a routine tarsal tunnel decompression in a patient with fluctuating plantar foot symptoms and "normal" magnetic resonance imaging findings, we identified cyst fluid within an articular branch of the lateral plantar nerve to the subtalar joint. Our incidental intraoperative discovery was corroborated by retrospective review of the magnetic resonance images. Although we do not know whether this cyst was responsible for the patient's complaints, we believe this finding represents a snapshot into the life cycle of intraneural ganglion cysts: either the "birth" of an ultra-early one or the remnant of a once larger one...
January 2017: Journal of Foot and Ankle Surgery: Official Publication of the American College of Foot and Ankle Surgeons
https://www.readbyqxmd.com/read/27956234/osteochondral-lesions-of-the-talus-and-autologous-matrix-induced-chondrogenesis-is-age-a-negative-predictor-outcome
#12
Riccardo D'Ambrosi, Camilla Maccario, Nicola Serra, Federico Liuni, Federico Giuseppe Usuelli
PURPOSE: To assess and evaluate healing and functional outcomes after arthroscopic talus autologous matrix-induced chondrogenesis (AT-AMIC) in 2 age groups: patients older than 33 years versus patients 33 years or younger. METHODS: A total of 31 patients, of whom 17 were 33 years or younger (G1) and 14 older than 33 years (G2), were evaluated. All patients were treated with AT-AMIC repair for osteochondral talar lesion. Magnetic resonance imaging (MRI) and computed tomography (CT)-scan evaluations, as well as clinical evaluations measured by the visual analog scale (VAS) score for pain, American Orthopaedic Foot and Ankle Society Ankle and Hindfoot score (AOFAS), and Short Form-12, were performed preoperatively (T0) and at 6 (T1), 12 (T2), and 24 (T3) months postoperatively...
December 9, 2016: Arthroscopy: the Journal of Arthroscopic & related Surgery
https://www.readbyqxmd.com/read/27917302/characterization-of-the-blood-brain-barrier-in-pediatric-central-nervous-system-neoplasms
#13
Christopher S Hong, Winson Ho, Martin G Piazza, Abhik Ray-Chaudhury, Zhengping Zhuang, John D Heiss
OBJECTIVE: The normal blood-brain barrier (BBB) is composed of tight junctions between endothelial cells and surrounding astrocyte foot processes. Breakdown of the physiological astrocyte-endothelial cell relationship occurs in adult metastatic and primary brain tumors. However, the astrocyte-endothelial cell relationship has not been studied in pediatric tumors. MATERIALS AND METHODS: Utilizing specimens from cases of pilocytic astrocytoma (n = 5), medulloblastoma (n = 5), and low-grade diffuse astrocytoma (n = 1), immunofluorescence were performed using primary antibodies against CD31, glial fibrillary acidic protein (GFAP), and aquaporin 4 (AQ4)...
2016: Journal of Interdisciplinary Histopathology
https://www.readbyqxmd.com/read/27909274/-three-mitral-valve-operations-in-a-patient-with-trousseau-syndrome-and-nonbacterial-thrombotic-endocarditis-caused-by-ovarian-cancer
#14
Masahito Saito, Naoki Asano, Kazunori Ota, Kazuho Niimi, Koyu Tanaka, Shigeyoshi Gon, Hiroshi Takano
A 52-year-old woman was admitted to our hospital for acute right hemi-paresis, left homonymous hemianopia, and fever. Magnetic resonance imaging of the brain showed multiple cerebral infarctions and transesophageal echocardiography (TEE) revealed a vegetation on the posterior leaflet of her mitral valve. Mitral valve repair was performed under a diagnosis of infective endocarditis (IE). Further multiple cerebral infarctions occurred on the 11th postoperative day, resulting in left hemiplegia and dysarthria...
December 2016: Kyobu Geka. the Japanese Journal of Thoracic Surgery
https://www.readbyqxmd.com/read/27906945/ganglion-cyst-at-the-proximal-tibiofibular-joint-in-a-patient-with-painless-foot-drop
#15
Abdulmuhsen Alsahhaf, Waleed Renno
Entrapment neuropathies of the fibular nerve and its branches are often underdiagnosed due to the lack of reliable diagnosis using clinical examination and electrophysiologic evaluation. Most fibular nerve compressions may be classified into 2 broad categories: (a) mechanical causes, which occur at fibrous or fibro-osseous tunnels, and (b) dynamic causes related to nerve injury during specific limb positioning. Foot drop resulting from weakness of the dorsiflexor muscles of the foot is a relatively uncommon presentation and closely related to L5 neuropathy caused by a disc herniation...
November 2016: Pain Physician
https://www.readbyqxmd.com/read/27904756/ct-negative-mri-gre-positive-primary-motor-cortex-contusion-causing-isolated-foot-drop
#16
Alexander M Tucker, Tianyi Niu, Daniel T Nagasawa, Richard Everson, Shaina Sedighim, Manuel M Buitrago Blanco
BACKGROUND: Isolated acute foot drop due to traumatic brain injury is exceedingly rare and is often misdiagnosed during initial evaluation. Here, we present the case of a patient who presented with left foot drop after falling off a bicycle. CASE DESCRIPTION: The patient is a 55-year-old male who was mountain biking when he fell, hit his head, and lost consciousness. Neurologic examination of the left leg revealed foot drop, no sensory deficits, and 3+ reflexes at the knee and ankle with clonus...
2016: Surgical Neurology International
https://www.readbyqxmd.com/read/27900226/laparoscopic-extirpation-of-a-schwannoma-in-the-lateral-pelvic-space
#17
Eiji Hidaka, Yasuhiro Ishiyama, Chiyo Maeda, Kenta Nakahara, Shoji Shimada, Shumpei Mukai, Naruhiko Sawada, Fumio Ishida, Shin-Ei Kudo
Schwannomas in the lateral pelvic space are very rare. Here, we report the case of a 48-year-old woman who had a tumor detected in her abdomen by abdominal ultrasonography. Abdominal computed tomography and magnetic resonance imaging revealed a well-defined solid tumor of 65 mm in diameter in the right lateral pelvic space. We performed laparoscopic surgery under a diagnosis of a gastrointestinal tumor or neurogenic tumor. The tumor was safely dissected and freed from the surrounding tissues using sharp and blunt maneuvers...
2016: Case Reports in Surgery
https://www.readbyqxmd.com/read/27886420/posterior-tibial-tendinopathy-associated-with-matrix-metalloproteinase-13-promoter-genotype-and-haplotype
#18
REVIEW
Francielle Boçon de Araujo Munhoz, José Eduardo Baroneza, Alexandre Godoy-Santos, Túlio Diniz Fernandes, Filipe Polese Branco, Lupe Furtado Alle, Ricardo Lehtonen de Souza, Maria Cristina Leme Godoy Dos Santos
BACKGROUND: Posterior tibial tendon (PTT) is particularly vulnerable and its insufficiency is recognized as the main cause of adult acquired flat foot. Some patients have a predisposition without a clinically recognized cause, suggesting that individual characteristics play an important role in tendinopathy. The present study investigated whether genetic variants in matrix metalloproteinases (MMPs) are associated with PTT dysfunction. METHODS: One hundred women who presented PTT dysfunction, with histopathological examination of the tendon and magnetic resonance imaging (MRI) confirming tendinopathy, as well as 100 asymptomatic women who presented intact PPT as assessed by MRI and constituting the control group, were evaluated for MMP-13 g...
November 2016: Journal of Gene Medicine
https://www.readbyqxmd.com/read/27886207/characteristic-tetrapod-musculoskeletal-limb-phenotype-emerged-more-than-400-mya-in-basal-lobe-finned-fishes
#19
Rui Diogo, Peter Johnston, Julia L Molnar, Borja Esteve-Altava
Previous accounts of the origin of tetrapod limbs have postulated a relatively sudden change, after the split between extant lobe-finned fish and tetrapods, from a very simple fin phenotype with only two muscles to the highly complex tetrapod condition. The evolutionary changes that led to the muscular anatomy of tetrapod limbs have therefore remained relatively unexplored. We performed dissections, histological sections, and MRI scans of the closest living relatives of tetrapods: coelacanths and lungfish. Combined with previous comparative, developmental and paleontological information, our findings suggest that the characteristic tetrapod musculoskeletal limb phenotype was already present in the Silurian last common ancestor of extant sarcopterygians, with the exception of the autopod (hand/foot) structures, which have no clear correspondence with fish structures...
November 25, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27865318/medical-imaging-in-differentiating-the-diabetic-charcot-foot-from-osteomyelitis
#20
REVIEW
Daniel J Short, Thomas Zgonis
Diabetic Charcot neuroarthropathy (DCN) poses a great challenge to diagnose in the early stages and when plain radiographs do not depict any initial signs of osseous fragmentation or dislocation in a setting of a high clinical index of suspicion. Medical imaging, including magnetic resonance imaging, computed tomography, and advanced bone scintigraphy, has its own unique clinical indications when treating the DCN with or without concomitant osteomyelitis. This article reviews different clinical case scenarios for choosing the most accurate medical imaging in differentiating DCN from osteomyelitis...
January 2017: Clinics in Podiatric Medicine and Surgery
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