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https://www.readbyqxmd.com/read/28340550/high-prevalence-of-vitamin-d-deficiency-in-patients-with-bone-marrow-edema-syndrome-of-the-foot-and-ankle
#1
Konstantin Horas, Lukas Fraissler, Gerrit Maier, Franz Jakob, Lothar Seefried, Christian Konrads, Maximilian Rudert, Matthias Walcher
BACKGROUND: Bone marrow edema syndrome (BMOS) is a phenomenon primarily affecting the lower extremity. It is characterized by a sudden onset of pain and an ill-defined osseous hyperintense signal in magnetic resonance imaging. The main cause of BMOS is still largely unknown. Its pathophysiology is presumably multifactorial and it has recently been demonstrated that it usually involves an increase in bone turnover and alterations within the bone microenvironment. Vitamin D plays a pivotal role in maintaining a healthy and well-balanced bone microenvironment...
March 1, 2017: Foot & Ankle International
https://www.readbyqxmd.com/read/28336447/anatomical-reconstruction-of-the-fourth-brachymetatarsia-with-one-stage-iliac-bone-and-cartilage-cap-grafting
#2
Sang-Hyun Woo, Chi Young Bang, Hee-Chan Ahn, Sung-Jung Kim, Jun-Young Choi
BACKGROUND: We present a one-stage procedure for lengthening the fourth brachymetatarsia with autogenous iliac bone and cartilage cap grafting for the anatomical reconstruction of the metatarsophalangeal (MTP) joint METHODS: During the last 8 years, 56 feet in 41 patients with congenital brachymetatarsia of the fourth toe were corrected with a one-stage operation to reposition the articular cartilage cap to the distal part of interpositional iliac bone graft at the metatarsal epiphysis...
February 28, 2017: Journal of Plastic, Reconstructive & Aesthetic Surgery: JPRAS
https://www.readbyqxmd.com/read/28336046/charcot-arthropathy-versus-osteomyelitis-evaluation-and-management
#3
REVIEW
John Womack
Charcot arthropathy of the foot and ankle is a severe complication of peripheral neuropathy and is most commonly seen in the developed world in association with diabetes mellitus. Correct diagnosis and differentiation from osteomyelitis of the foot and ankle are critical to guide treatment. It can exist concomitantly with osteomyelitis, typically in the setting of an advanced midfoot ulcer. Simple plain radiographs and contrasted MRI studies often yield inconclusive or confusing data. Correct use of imaging studies and a clinical algorithm can be effective tools to help make accurate and early diagnoses and guide clinical interventions for these conditions...
April 2017: Orthopedic Clinics of North America
https://www.readbyqxmd.com/read/28330501/intraarterial-transplantation-of-human-umbilical-cord-blood-mononuclear-cells-in-hyperacute-stroke-improves-vascular-function
#4
Lei Huang, Yichu Liu, Jianfei Lu, Bianca Cerqueira, Vivek Misra, Timothy Q Duong
BACKGROUND: Human umbilical cord blood (hUCB) cell therapy is a promising treatment for ischemic stroke. The effects of hyperacute stem cell transplantation on cerebrovascular function in ischemic stroke are, however, not well understood. This study evaluated the effects of hyperacute intraarterial transplantation of hUCB mononuclear cells (MNCs) on cerebrovascular function in stroke rats using serial magnetic resonance imaging (MRI). METHODS: HUCB MNCs or vehicle were administered to stroke rats via the internal carotid artery immediately after reperfusion at 60 min following ischemia onset...
March 22, 2017: Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/28329748/extensive-multilevel-split-laminotomy-for-debulking-a-cervicothoracolumbar-nondysraphic-intramedullary-spinal-cord-lipoma-in-a-2-month-old-infant
#5
Ha Son Nguyen, Sean Lew
INTRODUCTION: Laminectomy is the traditional approach for posterior exposure of the spinal canal for tumor resection. Another technique is split laminotomy, which entails the division and retraction of the spinous processes and laminae to access the thecal sac. This technique has been employed for small-segment exposures, but not extensively explored for long-segment exposures. CASE: A 2-month-old male presented with progressive right-leg plegia. MRI of the spine revealed a large, intramedullary spinal-cord lipoma extending from C6 to L5...
March 23, 2017: Pediatric Neurosurgery
https://www.readbyqxmd.com/read/28326157/partial-calcanectomy-and-ilizarov-external-fixation-may-reduce-amputation-need-in-severe-diabetic-calcaneal-ulcers
#6
Mehmet Orçun Akkurt, Ismail Demirkale, Ali Öznur
Objective: The treatment of diabetic hindfoot ulcers is a challenging problem. In addition to serial surgical debridements, hyperbaric oxygen therapy and local wound care play important roles in the surgeon's armamentarium, for both superficial infection and gangrene of the soft tissue, often complicated by osteomyelitis of the calcaneus. The purpose of this study was to evaluate the results of an aggressive approach from diagnosis to treatment of calcaneal osteomyelitis in foot-threatening diabetic calcaneal ulcers...
2017: Diabetic Foot & Ankle
https://www.readbyqxmd.com/read/28321186/brain-activity-during-mental-imagery-of-gait-versus-gait-like-plantar-stimulation-a-novel-combined-functional-mri-paradigm-to-better-understand-cerebral-gait-control
#7
Matthieu Labriffe, Cédric Annweiler, Liubov E Amirova, Guillemette Gauquelin-Koch, Aram Ter Minassian, Louis-Marie Leiber, Olivier Beauchet, Marc-Antoine Custaud, Mickaël Dinomais
Human locomotion is a complex sensorimotor behavior whose central control remains difficult to explore using neuroimaging method due to technical constraints, notably the impossibility to walk with a scanner on the head and/or to walk for real inside current scanners. The aim of this functional Magnetic Resonance Imaging (fMRI) study was to analyze interactions between two paradigms to investigate the brain gait control network: (1) mental imagery of gait, and (2) passive mechanical stimulation of the plantar surface of the foot with the Korvit boots...
2017: Frontiers in Human Neuroscience
https://www.readbyqxmd.com/read/28303206/post-irradiation-lumbosacral-radiculopathy-associated-with-multiple-cavernous-malformations-of-the-cauda-equina-case-report-and-review-of-the-literature
#8
Doniel Drazin, Ari Kappel, Stefan Withrow, Tiffany Perry, Ray Chu, Surasak Phuphanich
BACKGROUND: Multiple radiation-induced cavernous malformations of the cauda equina are extremely rare. A review of the literature suggested that the post-irradiation lumbosacral radiculopathy in our patient was most likely associated with a diagnosis of multiple radiation-induced cavernous malformations of the cauda equina. CASE DESCRIPTION: A 76-year-old man with a remote history of abdominal radiation therapy presented with a 6-month history of progressively worsening right foot drop and balance impairment...
2017: Surgical Neurology International
https://www.readbyqxmd.com/read/28302229/dot-in-circle-sign-a-diagnostic-mri-sign-for-madura-foot
#9
Faiza Javed, Rashid Nazir, Manoj Sharma, Sanam Yasir, Sadia Babar
Mycetoma is a slowly progressive localised, granulomatous, subcutaneous tissue infection common among adult males aged 20 - 50 years. The causing agents include both bacteria (actinomycetoma) and fungi (eumycetoma). This chronic infection was described in literature as Madura foot and eventually mycetoma, due to its etiology. Early clinical diagnosis before the appearance of sinuses and grains (aggregates of organism surrounded by granulation tissue, which are discharged from the draining sinuses) is difficult...
March 2017: Journal of the College of Physicians and Surgeons—Pakistan: JCPSP
https://www.readbyqxmd.com/read/28297693/-a-case-of-central-type-disc-herniation-at-the-c7-t1-level-presenting-with-myelopathy
#10
Masatoshi Yunoki, Takahiro Kanda, Kenta Suzuki, Atsuhito Uneda, Koji Hirashita, Kimihiro Yoshino
In contrast to other levels of upper disc spaces, the Luschka joints are usually absent at the C7/T1 disc space. Therefore, it has been reported that the C7/T1 disc herniation is prone to herniate laterally rather than centrally. In this manuscript, we describe an extremely rare central-type disc herniation at the C7/T1 level presented with myelopathy. A 76-year-old man presented with a 20-day history of progressive gait disturbance. Physical examination revealed bilateral lower extremity hyperreflexia and mild foot numbness with no upper extremity motor weakness or sensory disturbance...
March 2017: No Shinkei Geka. Neurological Surgery
https://www.readbyqxmd.com/read/28289599/quantitative-measures-of-walking-and-strength-provide-insight-into-brain-corticospinal-tract-pathology-in-multiple-sclerosis
#11
Nora E Fritz, Jennifer Keller, Peter A Calabresi, Kathleen M Zackowski
At least 85% of individuals with multiple sclerosis report walking dysfunction as their primary complaint. Walking and strength measures are common clinical measures to mark increasing disability or improvement with rehabilitation. Previous studies have shown an association between strength or walking ability and spinal cord MRI measures, and strength measures with brainstem corticospinal tract magnetization transfer ratio. However, the relationship between walking performance and brain corticospinal tract magnetization transfer imaging measures and the contribution of clinical measurements of walking and strength to the underlying integrity of the corticospinal tract has not been explored in multiple sclerosis...
2017: NeuroImage: Clinical
https://www.readbyqxmd.com/read/28282537/a-large-solitary-fibroma-of-the-deep-compartment-of-the-sole
#12
T H Lui
A 50-year-old lady presented with a right foot mass and pain for 1year. Magnetic resonance imaging showed a 3.9×3.2×5cm mass on plantar side of the forefoot deep to the major flexor tendons and plantar aponeurosis and inferior to 1st-4th metatarsals. The mass extended dorsally through the intermetatarsal space to the foot dorsum. Ultrasound guided biopsy was performed, which confirmed it was a fibroma. This case was further complicated by pathological fracture of the 3rd metatarsal. It was resected through a dorsal incision and surgical dislocation of the 2nd and 3rd tarsometatarsal joints...
December 7, 2016: Foot
https://www.readbyqxmd.com/read/28263926/dopamine-depletion-impairs-gait-automaticity-by-altering-cortico-striatal-and-cerebellar-processing-in-parkinson-s-disease
#13
Moran Gilat, Peter T Bell, Kaylena A Ehgoetz Martens, Matthew J Georgiades, Julie M Hall, Courtney C Walton, Simon J G Lewis, James M Shine
Impairments in motor automaticity cause patients with Parkinson's disease to rely on attentional resources during gait, resulting in greater motor variability and a higher risk of falls. Although dopaminergic circuitry is known to play an important role in motor automaticity, little evidence exists on the neural mechanisms underlying the breakdown of locomotor automaticity in Parkinson's disease. This impedes clinical management and is in great part due to mobility restrictions that accompany the neuroimaging of gait...
March 3, 2017: NeuroImage
https://www.readbyqxmd.com/read/28248538/possible-pathogenetic-mechanisms-and-new-therapeutic-approaches-of-pes-equinovarus
#14
M Ošťádal, J Lišková, D Hadraba, A Eckhardt
Idiopathic pes equinovarus (clubfoot) is a congenital deformity of the foot and lower leg defined as a fixation of the foot in plantar flexion, adduction, supination and varus. The deformity does not affect only the foot position, which is usually investigated by radiography, CT, micro-CT, MRI or ultrasound but logically influence the whole gait biomechanics. It is supposed, that clubfoot belongs to a group of fibroproliferative disorders whose origin and multi-hierarchical effect remain unknown. It has been suggested that fibroblasts and growth factors may be involved...
February 28, 2017: Physiological Research
https://www.readbyqxmd.com/read/28245539/-a-case-of-hydrocephalus-due-to-brain-metastasis-from-renal-cell-carcinoma-successfully-treated-with-axitinib
#15
Soichiro Shimura, Dai Koguchi, Satoru Minamida, Yoshinori Taoka, Masatsugu Iwamura
We report a case of hydrocephalus due to brain metastasis from renal cell carcinoma treated with axitinib. A 65-year-old man had undergone right radical nephrectomy for renal cell carcinoma in 2010. The pathological diagnosis indicated clear cell carcinoma G3, pT1a. After adjuvant treatment with interferon-α, computed tomography, in 2011, revealed multiple lung metastases. He was administered sorafenib. Because of progressive lung metastases, sunitinib was administered. The lung metastases were progressive and bone scan revealed multiple bone metastases...
January 2017: Hinyokika Kiyo. Acta Urologica Japonica
https://www.readbyqxmd.com/read/28236079/the-2017-abjs-nicolas-andry-award-advancing-personalized-medicine-for-clubfoot-through-translational-research
#16
Matthew B Dobbs, Christina A Gurnett
BACKGROUND: Clubfoot is one of the most common pediatric orthopaedic disorders. While the Ponseti method has revolutionized clubfoot treatment, it is not effective for all patients. When the Ponseti method does not correct the foot, patients are at risk for lifelong disability and may require more-extensive surgery. QUESTIONS/PURPOSES: (1) What genetic and morphologic abnormalities contribute to the development of clubfoot? (2) How can this information be used to devise personalized treatment paradigms for patients with clubfoot? METHODS: Human gene sequencing, molecular genetic engineering of mouse models of clubfoot, MRI of clubfoot, and development of new treatment methods all have been used by our group to understand the biological basis and improve therapy for this group of disorders...
February 24, 2017: Clinical Orthopaedics and related Research
https://www.readbyqxmd.com/read/28229931/modulation-of-the-sensorimotor-system-by-sustained-manual-pressure-stimulation
#17
Pavel Hok, Jaroslav Opavský, Miroslav Kutín, Zbyněk Tüdös, Petr Kaňovský, Petr Hluštík
In Vojta physiotherapy, also known as reflex locomotion therapy, prolonged peripheral pressure stimulation induces complex generalized involuntary motor responses and modifies subsequent behavior, but its neurobiological basis remains unknown. We hypothesized that the stimulation would induce sensorimotor activation changes in functional magnetic resonance imaging (fMRI) during sequential finger opposition. Thirty healthy volunteers (mean age 24.2) underwent two randomized fMRI sessions involving manual pressure stimulation applied either at the right lateral heel according to Vojta, or at the right lateral ankle (control site)...
February 14, 2017: Neuroscience
https://www.readbyqxmd.com/read/28229181/endoscopic-surgery-in-athletes-with-a-symptomatic-calcaneal-lipoma
#18
P D'Hooghe, B Krivokapic, P Dzendrowskyj, K Hassoun, B Bukva, P Landreau
PURPOSE: This study shows that endoscopy is an effective treatment modality for athletes with a symptomatic calcaneal lipoma. METHODS: Between 2013 and 2016, five professional athletes with symptomatic calcaneal lipoma underwent endoscopic-assisted curettage and bone graft treatment. Lipoma size was measured by magnetic resonance imaging (MRI) and rated using the American Orthopaedic Foot and Ankle Society Ankle-Hindfoot Scale (AOFAS). All athletes were followed up for 12 months postoperatively and monitored on return to previous activity level...
February 22, 2017: Knee Surgery, Sports Traumatology, Arthroscopy: Official Journal of the ESSKA
https://www.readbyqxmd.com/read/28222547/brain-plasticity-after-implanted-peroneal-nerve-electrical-stimulation-to-improve-gait-in-chronic-stroke-patients-two-case-reports
#19
Aurore Thibaut, Florent Moissenet, Carol Di Perri, Céline Schreiber, Angélique Remacle, Elisabeth Kolanowski, Frédéric Chantraine, Claire Bernard, Roland Hustinx, Jean-Flory Tshibanda, Paul Filipetti, Steven Laureys, Olivia Gosseries
BACKGROUND: Recent studies have shown that stimulation of the peroneal nerve using an implantable 4-channel peroneal nerve stimulator could improve gait in stroke patients. OBJECTIVES: To assess structural cortical and regional cerebral metabolism changes associated with an implanted peroneal nerve electrical stimulator to correct foot drop related to a central nervous system lesion. METHODS: Two stroke patients presenting a foot drop related to a central nervous system lesion were implanted with an implanted peroneal nerve electrical stimulator...
February 6, 2017: NeuroRehabilitation
https://www.readbyqxmd.com/read/28220401/numerical-model-for-healthy-and-injured-ankle-ligaments
#20
Antonella Forestiero, Emanuele Luigi Carniel, Chiara Giulia Fontanella, Arturo Nicola Natali
The aim of this work is to provide a computational tool for the investigation of ankle mechanics under different loading conditions. The attention is focused on the biomechanical role of ankle ligaments that are fundamental for joints stability. A finite element model of the human foot is developed starting from Computed Tomography and Magnetic Resonance Imaging, using particular attention to the definition of ankle ligaments. A refined fiber-reinforced visco-hyperelastic constitutive model is assumed to characterize the mechanical response of ligaments...
February 20, 2017: Australasian Physical & Engineering Sciences in Medicine
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