keyword
https://read.qxmd.com/read/38338799/adverse-childhood-experiences-and-the-risk-of-multiple-sclerosis-development-a-review-of-potential-mechanisms
#21
REVIEW
Karine Eid, Marte-Helene Bjørk, Nils Erik Gilhus, Øivind Torkildsen
Adverse childhood experiences (ACEs), such as abuse, neglect, and household dysfunction, contribute to long-term systemic toxic stress and inflammation that may last well into adulthood. Such early-life stressors have been associated with increased susceptibility to multiple sclerosis (MS) in observational studies and with the development of experimental autoimmune encephalomyelitis in animal models. In this review, we summarize the evidence for an ACE-mediated increase in MS risk, as well as the potential mechanisms for this association...
January 26, 2024: International Journal of Molecular Sciences
https://read.qxmd.com/read/38336772/role-of-fenofibrate-in-multiple-sclerosis
#22
REVIEW
Ahmad A Abulaban, Hayder M Al-Kuraishy, Ali I Al-Gareeb, Engy Elekhnawy, Asma Alanazi, Athanasios Alexiou, Marios Papadakis, Gaber El-Saber Batiha
Multiple sclerosis (MS) is the most frequent inflammatory and demyelinating disease of the central nervous system (CNS). The underlying pathophysiology of MS is the destruction of myelin sheath by immune cells. The formation of myelin plaques, inflammation, and injury of neuronal myelin sheath characterizes its neuropathology. MS plaques are multiple focal regions of demyelination disseminated in the brain's white matter, spinal cords, deep grey matter, and cerebral cortex. Fenofibrate is a peroxisome proliferative activated receptor alpha (PPAR-α) that attenuates the inflammatory reactions in MS...
February 9, 2024: European Journal of Medical Research
https://read.qxmd.com/read/38335654/neuroprotective-effects-of-embelin-in-an-ethidium-bromide-induced-multiple-sclerosis-in-rats-modulation-of-p38-mapk-signaling-pathway
#23
JOURNAL ARTICLE
Anika, Shamsher Singh, Rimpi
BACKGROUND: Multiple sclerosis (MS) is a debilitating inflammatory disease characterized by demyelination, varied remyelination conservation, and partial axonal retention in central nervous system (CNS) lesions. The p38 mitogen-activated protein kinase (MAPK) pathway has been implicated in the pathophysiology of MS. Embelin (EMB), derived from the Embelia ribes plant, possesses diverse biological activities, including anti-inflammatory properties. OBJECTIVE: This study aimed to investigate the neuroprotective effects of EMB in an ethidium bromide (EB)-induced model of MS in Wistar rats...
February 8, 2024: International Immunopharmacology
https://read.qxmd.com/read/38335440/relationship-between-pattern-reversal-visual-evoked-potential-p100-wave-latency-and-dysfunctional-hdl-in-patients-with-multiple-sclerosis-subjected-to-an-optic-neuritis-attack-a-case-control-study
#24
JOURNAL ARTICLE
Gonul Vural, Sadiye Gumusyayla, Funda Karakoyunlu Eren, Serdar Barakli, Esra Demir Unal, Salim Neselioglu, Ozcan Erel
Optic neuritis frequently occurs during the clinical course of multiple sclerosis (MS). In this condition, demyelination of the optic nerve occurs, which electrophysiologically causes a delay in P100 wave latency. Sensitive cholesterol homeostasis is critical for the formation of the myelin sheath and for myelin to become functionally mature. High-density lipoprotein (HDL) becomes dysfunctional under oxidative stress and plays an important role in the pathogenesis of MS. In this study, HDL levels of MS patients suffering from optic neuritis were compared with those of healthy individuals, and the relationship between pattern reversal visual evoked potential (PRVEP) P100 wave latency and HDL levels in patients with optic neuritis attacks was analyzed...
February 9, 2024: Medicine (Baltimore)
https://read.qxmd.com/read/38331311/nitric-oxide-involvement-in-the-disability-and-active-disease-of-multiple-sclerosis-systematic-review-and-meta-analysis
#25
REVIEW
Brenda da Silva, Fernanda Tibolla Viero, Patrícia Rodrigues, Gabriela Trevisan
BACKGROUND: Multiple sclerosis (MS) is a chronic and immune-mediated disease of unknown etiology and leading to a physical and cognitive disability. Different studies suggest that nitrosative stress may play a pivotal role in the pathogenesis and disability in MS. Besides, reports evaluated NO and their metabolites, expressed by nitrite and nitrate (NOx) levels of MS patients compared with other pathologies, but did not evaluate disability and relapse/remission phases. OBJECTIVE: Thus, this study aimed to conduct a systematic review and meta-analysis of NOx levels in MS patients in relapse/remission phases and its involvement in patient disability...
February 6, 2024: Nitric Oxide: Biology and Chemistry
https://read.qxmd.com/read/38329927/multiscale-networks-in-multiple-sclerosis
#26
JOURNAL ARTICLE
Keith E Kennedy, Nicole Kerlero de Rosbo, Antonio Uccelli, Maria Cellerino, Federico Ivaldi, Paola Contini, Raffaele De Palma, Hanne F Harbo, Tone Berge, Steffan D Bos, Einar A Høgestøl, Synne Brune-Ingebretsen, Sigrid A de Rodez Benavent, Friedemann Paul, Alexander U Brandt, Priscilla Bäcker-Koduah, Janina Behrens, Joseph Kuchling, Susanna Asseyer, Michael Scheel, Claudia Chien, Hanna Zimmermann, Seyedamirhosein Motamedi, Josef Kauer-Bonin, Julio Saez-Rodriguez, Melanie Rinas, Leonidas G Alexopoulos, Magi Andorra, Sara Llufriu, Albert Saiz, Yolanda Blanco, Eloy Martinez-Heras, Elisabeth Solana, Irene Pulido-Valdeolivas, Elena H Martinez-Lapiscina, Jordi Garcia-Ojalvo, Pablo Villoslada
Complex diseases such as Multiple Sclerosis (MS) cover a wide range of biological scales, from genes and proteins to cells and tissues, up to the full organism. In fact, any phenotype for an organism is dictated by the interplay among these scales. We conducted a multilayer network analysis and deep phenotyping with multi-omics data (genomics, phosphoproteomics and cytomics), brain and retinal imaging, and clinical data, obtained from a multicenter prospective cohort of 328 patients and 90 healthy controls...
February 2024: PLoS Computational Biology
https://read.qxmd.com/read/38328177/instability-of-excitatory-synapses-in-experimental-autoimmune-encephalomyelitis-and-the-outcome-for-excitatory-circuit-inputs-to-individual-cortical-neurons
#27
Rebecca L Gillani, Eseza N Kironde, Sara Whiteman, Theodore J Zwang, Brian J Bacskai
Synapses are lost on a massive scale in the brain and spinal cord of people living with multiple sclerosis (PwMS), and this synaptic loss extends far beyond demyelinating lesions. Post-mortem studies show the long-term consequences of multiple sclerosis (MS) on synapses but do not inform on the early impacts of neuroinflammation on synapses that subsequently lead to synapse loss. How excitatory circuit inputs are altered across the dendritic tree of individual neurons under neuroinflammatory stress is not well understood...
January 24, 2024: bioRxiv
https://read.qxmd.com/read/38326561/spatial-correspondence-among-regional-gene-expressions-and-gray-matter-volume-loss-in-multiple-sclerosis
#28
JOURNAL ARTICLE
Paolo Preziosa, Loredana Storelli, Nicolò Tedone, Monica Margoni, Damiano Mistri, Matteo Azzimonti, Massimo Filippi, Maria A Rocca
In multiple sclerosis (MS), a non-random and clinically relevant pattern of gray matter (GM) volume loss has been described. Whether differences in regional gene expression might underlay distinctive pathological processes contributing to this regional variability has not been explored yet. Two hundred eighty-six MS patients and 172 healthy controls (HC) underwent a brain 3T MRI, a complete neurological evaluation and a neuropsychological assessment. Using Allen Human Brain Atlas, voxel-based morphometry and MENGA platform, we integrated brain transcriptome and neuroimaging data to explore the spatial cross-correlations between regional GM volume loss and expressions of 2710 genes involved in MS (p < 0...
February 7, 2024: Molecular Psychiatry
https://read.qxmd.com/read/38322749/sleep-disorders-and-fatigue-among-patients-with-ms-the-role-of-depression-stress-and-anxiety
#29
JOURNAL ARTICLE
Nassim Zekibakhsh Mohammadi, Amir Sam Kianimoghadam, Niloofar Mikaeili, Seyedeh Samaneh Asgharian, Mahdieh Jafari, Abbas Masjedi-Arani
Sleep disorders and fatigue represent prominent symptoms frequently experienced by individuals with multiple sclerosis (MS). Some psychological factors such as depression, stress, and anxiety seem to have a relationship with such problems. This study aimed to examine the role of depression, stress, and anxiety in predicting sleep disorders and fatigue among patients with MS. Employing a cross-sectional descriptive-correlational design, the study involved a sample size of 252 participants selected through purposive sampling based on inclusion and exclusion criteria...
2024: Neurology Research International
https://read.qxmd.com/read/38318860/alsuntangled-74-withania-somnifera-ashwagandha
#30
JOURNAL ARTICLE
Sartaj Jhooty, Paul Barkhaus, Andrew Brown, Javier Mascias Cadavid, Gregory T Carter, Jesse Crayle, Terry Heiman-Patterson, Xiaoyan Li, Elise Mallon, Christopher Mcdermott, Tasnim Mushannen, Gary Pattee, Dylan Ratner, Paul Wicks, Martina Wiedau, Richard Bedlack
ALSUntangled reviews alternative and off-label treatments on behalf of people with ALS (PALS) who ask about them. Here, we review withania somnifera (WS) commonly known as ashwagandha or winter cherry. WS has plausible mechanisms for slowing ALS progression because of its effects on inflammation, oxidative stress, autophagy, mitochondrial function, and apoptosis. Preclinical trials demonstrate that WS slows disease progression in multiple different animal models of ALS. Of the five individuals we found who described using WS for their ALS, two individuals reported moderate benefit while none reported experiencing any significant side effects...
February 6, 2024: Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration
https://read.qxmd.com/read/38306888/effects-of-crocin-on-inflammatory-biomarkers-and-mental-health-status-in-patients-with-multiple-sclerosis-a-randomized-double-blinded-clinical-trial
#31
RANDOMIZED CONTROLLED TRIAL
Ebrahim Kouchaki, Hossein Rafiei, Amir Ghaderi, Mohammad-Javad Azadchehr, Fateme Safa, Kosar Omidian, Adeleh Khodabakhshi, Farhad Vahid, Bahador Rezapoor-Kafteroodi, Hamid-Reza Banafshe, Nasim Safa
BACKGROUND: Multiple sclerosis (MS), as a demyelinating disease correlated with inflammation and oxidative stress, affects the central nervous system and causes a wide range of complications, including psychiatric disorders. Considering the anti-inflammatory and antioxidant properties associated with the bioactive components of saffron, such as crocin (trans-crocetin bis(β-d-gentiobiosyl) ester), and their potential impact on ameliorating psychiatric symptoms, our study aimed to investigate the effect of crocin on biomarkers of inflammation, oxidative stress, and mental health, e...
March 2024: Multiple Sclerosis and related Disorders
https://read.qxmd.com/read/38288843/application-of-nanocomposites-and-nanoparticles-in-treating-neurodegenerative-disorders
#32
JOURNAL ARTICLE
Javeria Fatima, Yasir Hasan Siddique
Neurodegenerative diseases represent a formidable global health challenge, affecting millions and imposing substantial burdens on healthcare systems worldwide. Conditions, like Alzheimer's, Parkinson's, and Huntington's diseases, among others, share common characteristics, such as neuronal loss, misfolded protein aggregation, and nervous system dysfunction. One of the major obstacles in treating these diseases is the presence of the blood-brain barrier, limiting the delivery of therapeutic agents to the central nervous system...
January 29, 2024: CNS & Neurological Disorders Drug Targets
https://read.qxmd.com/read/38272385/dimethyl-fumarate-induces-cardiac-developmental-toxicity-in-zebrafish-via-down-regulation-of-oxidative-stress
#33
JOURNAL ARTICLE
Mengqi Wan, Jiejun Liu, Dou Yang, Zhonghao Xiao, Xue Li, Jieping Liu, Ling Huang, Fasheng Liu, Shouhua Zhang, Qiang Tao, Juhua Xiao, Zigang Cao
Dimethyl fumarate (DMF) is an immunosuppressant commonly used to treat multiple sclerosis and other autoimmune diseases. Despite known side effects such as lymphopenia, the effect of DMF on cardiac development remains unclear. To assess this, we used zebrafish to evaluate the cardiac developmental toxicity of DMF. Our study showed that DMF reduced the survival rate of zebrafish embryos, with those exposed to 1, 1.3, and 1.6mg/L exhibiting heart rate reduction, shortened body length, delayed yolk sac absorption, pericardial edema, increased distance from sinus venous to bulbus arteriosus, and separation of cardiomyocytes and endocardial cells at 72 hpf...
January 23, 2024: Toxicology
https://read.qxmd.com/read/38261254/potential-roles-of-nr4a3-mediated-inflammation-in-immunological-and-neurological-diseases
#34
REVIEW
Siqi He, Weijie Jiang, Baoyi Jiang, Chunyan Yu, Guifang Zhao, Yifei Li, Ling Qi, Jia Zhang, Dan Wang
As a protein of the orphan nuclear receptor Nr4a family, Nr4a3 has no identified natural ligands. However, its biological activity can be mediated by inducing conformational changes through interactions with specific certain small molecules and receptors. Nr4a3 is activated as an early stress factor under various pathological conditions and plays a regulatory role in various tissues and cells, participating in processes such as cell differentiation, apoptosis, metabolism, and homeostasis. At present, research on the role of Nr4a3 in the pathophysiology of inflammation is considerably limited, especially with respect to its role in the central nervous system (CNS)...
January 23, 2024: Molecular Neurobiology
https://read.qxmd.com/read/38255863/the-use-of-nitrosative-stress-molecules-as-potential-diagnostic-biomarkers-in-multiple-sclerosis
#35
JOURNAL ARTICLE
Saskia Räuber, Moritz Förster, Julia Schüller, Alice Willison, Kristin S Golombeck, Christina B Schroeter, Menekse Oeztuerk, Robin Jansen, Niklas Huntemann, Christopher Nelke, Melanie Korsen, Katinka Fischer, Ruth Kerkhoff, Yana Leven, Patricia Kirschner, Tristan Kölsche, Petyo Nikolov, Mohammed Mehsin, Gelenar Marae, Alma Kokott, Duygu Pul, Julius Schulten, Niklas Vogel, Jens Ingwersen, Tobias Ruck, Marc Pawlitzki, Sven G Meuth, Nico Melzer, David Kremer
Multiple sclerosis (MS) is an autoimmune disease of the central nervous system (CNS) of still unclear etiology. In recent years, the search for biomarkers facilitating its diagnosis, prognosis, therapy response, and other parameters has gained increasing attention. In this regard, in a previous meta-analysis comprising 22 studies, we found that MS is associated with higher nitrite/nitrate (NOx) levels in the cerebrospinal fluid (CSF) compared to patients with non-inflammatory other neurological diseases (NIOND)...
January 8, 2024: International Journal of Molecular Sciences
https://read.qxmd.com/read/38255384/parental-experiences-in-pediatric-multiple-sclerosis-insights-from-quantitative-research
#36
REVIEW
Samuela Tarantino, Martina Proietti Checchi, Laura Papetti, Gabriele Monte, Michela Ada Noris Ferilli, Massimiliano Valeriani
Multiple sclerosis (MS) is a chronic and unpredictable inflammatory disease impacting the central nervous system. The disabling nature of this disease is not limited to only physical symptoms. MS, even at a pediatric age, often includes cognitive impairment, fatigue, and psychological issues, affecting education and social life, causing emotional distress, and reducing quality of life. Despite the paucity of quantitative data in the existing literature, our review demonstrates that the impact of pediatric MS extends beyond the patients themselves, affecting their parents as well...
January 8, 2024: Children
https://read.qxmd.com/read/38252396/protective-effects-of-glatiramer-acetate-against-paclitaxel-induced-peripheral-neuropathy-in-rats-a-role-for-inflammatory-cytokines-and-oxidative-stress
#37
JOURNAL ARTICLE
Sajad Dekamin, Mehdi Ghasemi, Ahmad Reza Dehpour, Mahmoud Ghazi-Khansari, Hamed Shafaroodi
Chemotherapy-induced peripheral neuropathy (CIPN) is a major challenge for cancer patients who undergo chemotherapy with paclitaxel. Therefore, finding effective therapies for CIPN is crucial. Glatiramer acetate is used to treat multiple sclerosis that exerts neuroprotective properties in various studies. We hypothesized that glatiramer acetate could also improve the paclitaxel-induced peripheral neuropathy. We used a rat model of paclitaxel (2 mg/kg/every other day for 7 doses)-induced peripheral neuropathy...
January 22, 2024: Neurochemical Research
https://read.qxmd.com/read/38248227/vanillic-acid-ameliorates-demyelination-in-a-cuprizone-induced-multiple-sclerosis-rat-model-possible-underlying-mechanisms
#38
JOURNAL ARTICLE
Sally M Safwat, Mahmoud El Tohamy, Moutasem Salih Aboonq, Amaal Alrehaili, Ahmad A Assinnari, Abdulrahman S Bahashwan, Ahmed A ElGendy, Abdelaziz M Hussein
OBJECTIVE: To investigate the effect of vanillic acid (VA) on a Cuprizone (Cup) demyelinating rat model and the mechanisms behind such effect. METHODS: Thirty adult male Sprague Dawley (SD) rats were randomly divided into three groups: control, Cuprizone, and VA groups. Cuprizone was administrated at a dose of 450 mg/kg per day orally via gastric gavage for 5 weeks. The nerve conduction velocity (NCV) was studied in an isolated sciatic nerve, and then the sciatic nerve was isolated for histopathological examination, electron microscope examination, immunohistochemical staining, and biochemical and PCR assay...
December 22, 2023: Brain Sciences
https://read.qxmd.com/read/38247808/mechanisms-governing-oligodendrocyte-viability-in-multiple-sclerosis-and-its-animal-models
#39
REVIEW
Zhixin Lei, Wensheng Lin
Multiple sclerosis (MS) is a chronic autoimmune inflammatory demyelinating disease of the central nervous system (CNS), which is triggered by an autoimmune assault targeting oligodendrocytes and myelin. Recent research indicates that the demise of oligodendrocytes due to an autoimmune attack contributes significantly to the pathogenesis of MS and its animal model experimental autoimmune encephalomyelitis (EAE). A key challenge in MS research lies in comprehending the mechanisms governing oligodendrocyte viability and devising therapeutic approaches to enhance oligodendrocyte survival...
January 9, 2024: Cells
https://read.qxmd.com/read/38236003/characterization-of-an-italian-population-with-neurological-disorders-in-a-rehabilitation-setting-using-clinfit
#40
JOURNAL ARTICLE
Sara Liguori, Melissa Selb, Antimo Moretti, Marco Paoletta, Marco Invernizzi, Pietro Fiore, Giovanni Iolascon, Francesca Gimigliano
OBJECTIVE: To examine the functioning profile of people with neurological disorders who access rehabilitation services through ClinFIT Generic-30. METHODS: The functioning profile of people with neurological disorders accessing rehabilitation services was examined using the ClinFIT Generic-30, and the results compared with existing core set (neurological health conditions acute and post-acute,stroke, Multiple Sclerosis, Traumatic Brain Injury,Spinal Cord Injury)...
January 18, 2024: Journal of Rehabilitation Medicine
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