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JOURNAL ARTICLE
Gabriel S Stephens, Jin Park, Andrew Eagle, Jason You, Manuel Silva-Pérez, Chia-Hsuan Fu, Sumin Choi, Corey P St Romain, Chiho Sugimoto, Shelly A Buffington, Yi Zheng, Mauro Costa-Mattioli, Yin Liu, A J Robison, Jeannie Chin
Recurrent seizures lead to accumulation of the activity-dependent transcription factor ∆FosB in hippocampal dentate granule cells in both mouse models of epilepsy and mouse models of Alzheimer's disease (AD), which is also associated with increased incidence of seizures. In patients with AD and related mouse models, the degree of ∆FosB accumulation corresponds with increasing severity of cognitive deficits. We previously found that ∆FosB impairs spatial memory in mice by epigenetically regulating expression of target genes such as calbindin that are involved in synaptic plasticity...
April 18, 2024: Progress in Neurobiology
#2
JOURNAL ARTICLE
Neil Rosser, Fernando Seixas, Lucie M Queste, Bruna Cama, Ronald Mori-Pezo, Dmytro Kryvokhyzha, Michaela Nelson, Rachel Waite-Hudson, Matt Goringe, Mauro Costa, Marianne Elias, Clarisse Mendes Eleres de Figueiredo, André Victor Lucci Freitas, Mathieu Joron, Krzysztof Kozak, Gerardo Lamas, Ananda R P Martins, W Owen McMillan, Jonathan Ready, Nicol Rueda-Muñoz, Camilo Salazar, Patricio Salazar, Stefan Schulz, Leila T Shirai, Karina L Silva-Brandão, James Mallet, Kanchon K Dasmahapatra
Hybridization allows adaptations to be shared among lineages and may trigger the evolution of new species1,2 . However, convincing examples of homoploid hybrid speciation remain rare because it is challenging to demonstrate that hybridization was crucial in generating reproductive isolation3 . Here we combine population genomic analysis with quantitative trait locus mapping of species-specific traits to examine a case of hybrid speciation in Heliconius butterflies. We show that Heliconius elevatus is a hybrid species that is sympatric with both parents and has persisted as an independently evolving lineage for at least 180,000 years...
April 17, 2024: Nature
#3
MULTICENTER STUDY
Gennaro Perrone, Mario Giuffrida, Fikri Abu-Zidan, Vitor F Kruger, Marco Livrini, Gabriele Luciano Petracca, Giorgio Rossi, Antonio Tarasconi, Brian W C A Tian, Elena Bonati, Ricardo Mentz, Federico N Mazzini, Juan P Campana, Elisabeth Gasser, Reinhold Kafka-Ritsch, Daniel M Felsenreich, Christopher Dawoud, Stefan Riss, Carlos Augusto Gomes, Felipe Couto Gomes, Ricardo Alessandro Teixeira Gonzaga, Cassio Alfred Brattig Canton, Bruno Monteiro Pereira, Gustavo P Fraga, Leticia Gonçalves Zem, Vinicius Cordeiro-Fonseca, Renato de Mesquita Tauil, Boyko Atanasov, Nikolay Belev, Nikola Kovachev, L Juan José Meléndez, Ana Dimova, Stefan Dimov, Zdravko Zelić, Goran Augustin, Branko Bogdanić, Trpimir Morić, Elie Chouillard, Melinda Bajul, Belinda De Simone, Yves Panis, Francesco Esposito, Margherita Notarnicola, Lelde Lauka, Anna Fabbri, Hassen Hentati, Iskander Fnaiech, Venara Aurélien, Marie Bougard, Maxime Roulet, Zaza Demetrashvili, Irakli Pipia, Giorgi Merabishvili, Konstantinos Bouliaris, Georgios Koukoulis, Christos Doudakmanis, Sofia Xenaki, Emmanuel Chrysos, Stamatios Kokkinakis, Panteleimon Vassiliu, Nikolaos Michalopoulos, Ioannis Margaris, Aristotelis Kechagias, Konstantinos Avgerinos, Jevgeni Katunin, Eftychios Lostoridis, Eleni-Aikaterini Nagorni, Antonio Pujante, Francesk Mulita, Ioannis Maroulis, Michail Vailas, Athanasios Marinis, Ioannis Siannis, Eirini Bourbouteli, Dimitrios K Manatakis, Nikolaos Tasis, Vasileios Acheimastos, Sotiropoulou Maria, Kapiris Stylianos, Harilaos Kuzeridis, Dimitrios Korkolis, Evangelos Fradelos, George Kavalieratos, Thalia Petropoulou, Andreas Polydorou, Ioannis Papacostantinou, Tania Triantafyllou, Despina Kimpizi, Dimitrios Theodorou, Konstantinos Toutouzas, Alexandros Chamzin, Maximos Frountzas, Dimitrios Schizas, Ioannis Karavokyros, Athanasios Syllaios, Alexandros Charalabopoulos, Maria Boura, Efstratia Baili, Orestis Ioannidis, Lydia Loutzidou, Elissavet Anestiadou, Ioannis Tsouknidas, Georgios Petrakis, Eleni Polenta, Lovenish Bains, Rahul Gupta, Sudhir K Singh, Archana Khanduri, Miklosh Bala, Asaf Kedar, Marcello Pisano, Mauro Podda, Adolfo Pisanu, Gennaro Martines, Giuseppe Trigiante, Giuliano Lantone, Antonino Agrusa, Giuseppe Di Buono, Salvatore Buscemi, Massimiliano Veroux, Rossella Gioco, Gastone Veroux, Luigi Oragano, Sandro Zonta, Federico Lovisetto, Carlo V Feo, Antonio Pesce, Nicolò Fabbri, Giulio Lantone, Fabio Marino, Fabrizio Perrone, Leonardo Vincenti, Vincenzo Papagni, Arcangelo Picciariello, Stefano Rossi, Biagio Picardi, Simone Rossi Del Monte, Diego Visconti, Giulia Osella, Luca Petruzzelli, Giusto Pignata, Jacopo Andreuccetti, Rossella D'Alessio, Massimo Buonfantino, Eleonora Guaitoli, Stefano Spinelli, Gianluca Matteo Sampietro, Carlo Corbellini, Leonardo Lorusso, Alice Frontali, Isabella Pezzoli, Alessandro Bonomi, Andrea Chierici, Christian Cotsoglou, Giuseppe Manca, Antonella Delvecchio, Nicola Musa, Massimiliano Casati, Laface Letizia, Emmanuele Abate, Giorgio Ercolani, Fabrizio D'Acapito, Leonardo Solaini, Gianluca Guercioni, Simone Cicconi, Diego Sasia, Felice Borghi, Giorgio Giraudo, Giuseppe Sena, Pasquale Castaldo, Eugenia Cardamone, Giuseppe Portale, Matteo Zuin, Ylenia Spolverato, Marialusia Esposito, Roberta Maria Isernia, Maria Di Salvo, Romina Manunza, Giuseppe Esposito, Marcello Agus, Emanuele Luigi Giuseppe Asti, Daniele Tiziano Bernardi, Tommaso Panici Tonucci, Davide Luppi, Massimiliano Casadei, Stefano Bonilauri, Angela Pezzolla, Annunziata Panebianco, Rita Laforgia, Maurizio De Luca, Monica Zese, Dario Parini, Elio Jovine, Giuseppina De Sario, Raffaele Lombardi, Giovanni Aprea, Giuseppe Palomba, Marianna Capuano, Giulio Argenio, Gianluca Orio, Mariano Fortunato Armellino, Marina Troian, Martina Guerra, Carlo Nagliati, Alan Biloslavo, Paola Germani, Giada Aizza, Igor Monsellato, Ali Chaouki Chahrour, Gabriele Anania, Cristina Bombardini, Francesco Bagolini, Gabriele Sganga, Pietro Fransvea, Valentina Bianchi, Paolo Boati, Francesco Ferrara, Francesco Palmieri, Pasquale Cianci, Domenico Gattulli, Enrico Restini, Nicola Cillara, Alessandro Cannavera, Gabriela Elisa Nita, Jlenia Sarnari, Francesco Roscio, Federico Clerici, Ildo Scandroglio, Stefano Berti, Alessandro Cadeo, Alice Filippelli, Luigi Conti, Carmine Grassi, Gaetano Maria Cattaneo, Marina Pighin, Davide Papis, Giovanni Gambino, Vanessa Bertino, Domenico Schifano, Daniela Prando, Luisella Fogato, Fabio Cavallo, Luca Ansaloni, Roberto Picheo, Nicholas Pontarolo, Norma Depalma, Marcello Spampinato, Stefano D'Ugo, Luca Lepre, Michela Giulii Capponi, Rossella Domenica Campa, Giuliano Sarro, Vincenza Paola Dinuzzi, Stefano Olmi, Matteo Uccelli, Davide Ferrari, Marco Inama, Gianluigi Moretto, Michele Fontana, Francesco Favi, Erika Picariello, Alessia Rampini, Andrea Barberis, Antonio Azzinnaro, Alba Oliva, Luigi Totaro, Ilaria Benzoni, Valerio Ranieri, Gabriella Teresa Capolupo, Filippo Carannante, Marco Caricato, Maurizio Ronconi, Silvia Casiraghi, Giovanni Casole, Desire Pantalone, Giovanni Alemanno, Maximilian Scheiterle, Marco Ceresoli, Marco Cereda, Chiara Fumagalli, Federico Zanzi, Stefano Bolzon, Enrico Guerra, Francesca Lecchi, Paola Cellerino, Antonella Ardito, Rosa Scaramuzzo, Andrea Balla, Pasquale Lepiane, Nicola Tartaglia, Antonio Ambrosi, Giovanna Pavone, Gian Marco Palini, Simone Veneroni, Gianluca Garulli, Claudio Ricci, Beatrice Torre, Iris Shari Russo, Matteo Rottoli, Marta Tanzanu, Angela Belvedere, Marco Milone, Michele Manigrasso, Giovanni Domenico De Palma, Micaela Piccoli, Gianmaria Casoni Pattacini, Stefano Magnone, Paolo Bertoli, Michele Pisano, Paolo Massucco, Marco Palisi, Andrea-Pierre Luzzi, Francesco Fleres, Guglielmo Clarizia, Alessandro Spolini, Yoshiro Kobe, Takayuki Toma, Fumihiko Shimamura, Robert Parker, Sinkeet Ranketi, Mercy Mitei, Saulius Svagzdys, Henrikas Pauzas, Justas Zilinskas, Tomas Poskus, Marius Kryzauskas, Matas Jakubauskas, Andee Dzulkarnaen Zakaria, Zaidi Zakaria, Michael Pak-Kai Wong, Asri Che Jusoh, Muhammad Nazreen Zakaria, Daniel Rios Cruz, Aurea Barbara Rodriguez Elizalde, Alejandro Bañon Reynaud, Edgard Efren Lozada Hernandez, Jose Maria Victor Palomo Monroy, Diego Hinojosa-Ugarte, Martha Quiodettis, María Esther Du Bois, José Latorraca, Piotr Major, Michał Pędziwiatr, Magdalena Pisarska-Adamczyk, Maciej Walędziak, Andrzej Kwiatkowski, Łukasz Czyżykowski, Silvia Dantas da Costa, Bela Pereira, Ana Rita Oliveira Ferreira, Filipe Almeida, Ricardo Rocha, Carla Carneiro, Diego Pita Perez, João Carvas, Catarina Rocha, Cátia Ferreira, Rita Marques, Urânia Fernandes, Pedro Leao, André Goulart, Rita Gonçalves Pereira, Sara Daniela Direito Patrocínio, Nuno Gonçalo Gonçalves de Mendonça, Maria Isabel Cerqueira Manso, Henrique Manuel Cardoso Morais, Paulo Sebastião Cardoso, Valentin Calu, Adrian Miron, Elena Adelina Toma, Mahir Gachabayov, Abakar Abdullaev, Andrey Litvin, Taras Nechay, Alexander Tyagunov, Anvar Yuldashev, Alison Bradley, Michael Wilson, Arpád Panyko, Zuzana Látečková, Vladimír Lacko, Dusan Lesko, Marek Soltes, Jozef Radonak, Victor Turrado-Rodriguez, Roser Termes-Serra, Xavier Morales-Sevillano, Pierfrancesco Lapolla, Andrea Mingoli, Gioia Brachini, Maurizio Degiuli, Silvia Sofia, Rossella Reddavid, Andrea de Manzoni Garberini, Angelica Buffone, Eduardo Perea Del Pozo, Daniel Aparicio-Sánchez, Sandra Dos Barbeito, Mercedes Estaire-Gómez, Rebeca Vitón-Herrero, Mª de Los Ángeles Gil Olarte-Marquez, José Gil-Martínez, Felipe Alconchel, Tatiana Nicolás-López, Aida Cristina Rahy-Martin, María Pelloni, Raquel Bañolas-Suarez, Fernando Mendoza-Moreno, Francisca García-Moreno Nisa, Manuel Díez-Alonso, María Elisa Valle Rodas, María Carmona Agundez, María Inmaculada Pérez Andrés, Claudia Cristina Lopes Moreira, Aintzane Lizarazu Perez, Iñigo Augusto Ponce, Ana María González-Castillo, Estela Membrilla-Fernández, Silvia Salvans, Mario Serradilla-Martín, Pablo Sancho Pardo, Daniel Rivera-Alonso, Jana Dziakova, Jose Mugüerza Huguet, Naila Pagès Valle, Enrique Colás Ruiz, Cristina Rey Valcárcel, Cristina Ruiz Moreno, Yeniffer Tatiana Moreno Salazar, Juan Jesús Rubio García, Silvia Sevila Micó, Joaquín Ruiz López, Silvia Pérez Farré, Maite Santamaria Gomez, Nuria Mestres Petit, Alberto Titos-García, Jose Manuel Aranda-Narváez, Laura Romacho-López, Luis Sánchez-Guillén, Veronica Aranaz-Ostariz, Marina Bosch-Ramírez, Aleix Martínez-Pérez, Elías Martínez-López, Juan Carlos Sebastián-Tomás, Granada Jimenez-Riera, Javier Jimenez-Vega, Jose Aurelio Navas Cuellar, Andrea Campos-Serra, Anna Muñoz-Campaña, Raquel Gràcia-Roman, Javier Martínez Alegre, Francisca Lima Pinto, Sara Nuñez O'Sullivan, Francisco Blanco Antona, Beatriz Muñoz Jiménez, Jaime López-Sánchez, Zahira Gómez Carmona, Rocio Torres Fernández, Isabel Blesa Sierra, Laura Román García de León, Verónica Polaino Moreno, Eva Iglesias, Paola Lora Cumplido, Altea Arango Bravo, Ignacio Rey Simó, Carlota López Domínguez, Aloia Guerreiro Caamaño, Rafael Calleja Lozano, Manuel Durán Martínez, Álvaro Naranjo Torres, Javier Tomas Morales Bernaldo de Quiros, Gianluca Pellino, Miriam Moratal Cloquell, Elsa García Moller, Sami Jalal-Eldin, Ahmed K Abdoun, Hytham K S Hamid, Varut Lohsiriwat, Aitsariya Mongkhonsupphawan, Oussama Baraket, Karim Ayed, Imed Abbassi, Ali Ben Ali, Houssem Ammar, Ali Kchaou, Ahmed Tlili, Imen Zribi, Elif Colak, Suleyman Polat, Zehra Alan Koylu, Ali Guner, Mehmet Arif Usta, Murat Emre Reis, Baris Mantoglu, Emre Gonullu, Emrah Akin, Fatih Altintoprak, Zulfu Bayhan, Necattin Firat, Arda Isik, Ufuk Memis, Mehmet Bayrak, Yasemin Altıntaş, Yasin Kara, Mehmet Abdussamet Bozkurt, Ali Kocataş, Koray Das, Ahmet Seker, Nazmi Ozer, Semra Demirli Atici, Korhan Tuncer, Tayfun Kaya, Zeynep Ozkan, Onur Ilhan, Ibrahim Agackiran, Mustafa Yener Uzunoglu, Eren Demirbas, Yuksel Altinel, Serhat Meric, Nadir Adnan Hacım, Derya Salim Uymaz, Nail Omarov, Emre Balık, Giovanni D Tebala, Hany Khalil, Mridul Rana, Mansoor Khan, Charlotte Florence, Christie Swaminathan, Cosimo Alex Leo, Lampros Liasis, Josef Watfah, Ivan Trostchansky, Edward Delgado, Marcelo Pontillo, Rifat Latifi, Raul Coimbra, Sara Edwards, Ana Lopez, George Velmahos, Ander Dorken, Anthony Gebran, Amanda Palmer, Jeffrey Oury, James M Bardes, Sirivan Suon Seng, Lauren S Coffua, Asanthi Ratnasekera, Tanya Egodage, Karla Echeverria-Rosario, Isabella Armento, Lena M Napolitano, Naveen F Sangji, Mark Hemmila, Jacob A Quick, Tyler R Austin, Theodore S Hyman, William Curtiss, Amanda McClure, Nicholas Cairl, Walter L Biffl, Hung P Truong, Kathryn Schaffer, Summer Reames, Filippo Banchini, Patrizio Capelli, Federico Coccolini, Massimo Sartelli, Francesca Bravi, Carlo Vallicelli, Vanni Agnoletti, Gian Luca Baiocchi, Fausto Catena
BACKGROUND: Literature suggests colonic resection and primary anastomosis (RPA) instead of Hartmann's procedure (HP) for the treatment of left-sided colonic emergencies. We aim to evaluate the surgical options globally used to treat patients with acute left-sided colonic emergencies and the factors that leading to the choice of treatment, comparing HP and RPA. METHODS: This is a prospective, international, multicenter, observational study registered on ClinicalTrials...
April 16, 2024: World Journal of Emergency Surgery: WJES
#4
JOURNAL ARTICLE
Leonardo Gonçalves Ribeiro, Tatiana Rehder Gonçalves, Vitor Barreto Paravidino, Henrique Silveira Costa, Luiz Fernando Rodrigues Junior, Flavia Mazzoli-Rocha, Gilberto Marcelo Sperandio da Silva, Fernanda de Souza Nogueira Sardinha Mendes, Roberto Magalhães Saraiva, Alejandro Marcel Hasslocher-Moreno, Mauro Felippe Felix Mediano
BACKGROUND: Studies evaluating physical activity (PA) levels in individuals with Chagas disease (CD) are still scarce. The present study aimed to evaluate PA levels in CD individuals and examine their association with Chagas heart disease (ChHD). METHODS: We included patients with CD regularly followed in a reference center for treatment of infectious diseases. PA levels were assessed using the short version of the International Physical Activity Questionnaire (IPAQ)...
June 2024: IJC Heart & Vasculature
#5
JOURNAL ARTICLE
Ingridi Camboim Franceschi, Rubem Augusto da Paixão Dornas, Isabel Salgueiro Lermen, Artur Vicente Pfeifer Coelho, Ademir Henrique Vilas Boas, Adriano Garcia Chiarello, Adriano Pereira Paglia, Agnis Cristiane de Souza, Alana Rafaela Borsekowsky, Alessandro Rocha, Alex Bager, Alexander Zaidan de Souza, Alexandre Martins Costa Lopes, Aloysio Souza de Moura, Aluane Silva Ferreira, Alvaro García-Olaechea, Ana Cláudia Delciellos, Ana Elisa de Faria Bacellar, Ana Kellen Nogueira Campelo, Ana Maria Oliveira Paschoal, Anderson Claudino Rolim, André Luiz Ferreira da Silva, Andre Monnerat Lanna, André Pereira da Silva, Andresa Guimarães, Ângela Cardoso, Angelica Soligo Cassol, Anna Ludmilla da Costa-Pinto, Ariel Guilherme Santos do Nascimento, Arthur Soares Fernandes, Aryanne Clyvia, Aureo Banhos Dos Santos, Barbara Lima-Silva, Beatriz de Mello Beisiegel, Beatriz Fernandes Lima Luciano, Bernardo de Faria Leopoldo, Bruna Nunes Krobel, Bruno Busnello Kubiak, Bruno Henrique Saranholi, Bruno Senna Correa, Caio Sant Anna Teixeira, Camila Rezende Ayroza, Camila Righetto Cassano, Camilo Benitez-Riveros, Carla Cristina Gestich, Carla Denise Tedesco, Carla Gheler-Costa, Carla Grasiele Zanin Hegel, Carlito da Silva Evangelista Junior, Carlos Eduardo Morando Faria Ferreira, Carlos Eduardo Viveiros Grelle, Carolina Franco Esteves, Caroline da Costa Espinosa, Caroline Leuchtenberger, Catalina Sanchéz-Lalinde, Cauanne Iglesias Campos Machado, Cecilia Andreazzi, Cecília Bueno, Cecilia Cronemberger de Faria, Claudio Novaes, Cynthia Elisa Widmer, Cyntia Cavalcante Santos, Daniel da Silva Ferraz, Daniel Galiano, Daniela Aparecida Savariz Bôlla, Daniela Behs, Daniele Pereira Rodrigues, Danielle Picão de Melo, Déborah Maria Soares Ramos, Denise Lidório de Mattia, Diego Dias Pavei, Diogo Loretto, Douglas da Silva Huning, Douglas de Matos Dias, Éder Ricardo Paetzhold, Elaine Rios, Eleonore Zulnara Freire Setz, Eliana Cazetta, Emanuel Giovani Cafofo Silva, Emanuelle Pasa, Erica Naomi Saito, Erick Francisco Silva de Aguiar, Érika Paula Castro, Ernesto Bastos Viveiros de Castro, Ezequiel Pedó, Fabiane de Aguiar Pereira, Fábio Bolzan, Fábio de Oliveira Roque, Fábio Dias Mazim, Fábio Henrique Comin, Fábio Maffei, Felipe Bortolotto Peters, Felipe Moreli Fantacini, Felipe Pessoa da Silva, Felipe Santana Machado, Felipe Vélez-Garcia, Fernanda Stussi Duarte Lage, Fernando Araújo Perini, Fernando Camargo Passos, Fernando Carvalho, Fernando Cesar Cascelli de Azevedo, Fernando Ferreira, Fernando Ferreira de Pinho, Flávia Guimarães Chaves, Flavia Regina Miranda, Flavio Henrique Guimarães Rodrigues, Flávio Kulaif Ubaid, Francisco Homem Gabriel, Franco Leandro de Souza, Fred Victor de Oliveira, Gabriel Cupolillo, Gabriela de Araújo Pires Moreira, Gabriela Mette, Gabriela Teixeira Duarte, Gabrielle Beca, Gilberto Corso, Gilmar Perbiche-Neves, Glauber Henrique Borges de Oliveira Souto, Glenda Jéssica da Silva Vilarroel, Graziele O Batista, Guilherme Braga Ferreira, Gustavo Alves da Costa Toledo, Gustavo Senger, Helena de Godoy Bergallo, Hellen Cristina Pinheiro Dos Santos, Humberto Angelo Gazola, Isabel Melo, Ismael Verrastro Brack, Iuri Veríssimo, Ivan Réus Viana, Izabela Costa Laurentino, Jaime Luis Diehl, Jairo José Zocche, Jimi Martins-Silva, João Paulo Gava Just, Jorge José Cherem, Jorge Luiz Nascimento, Jorge Reppold Marinho, José Oliveira Dantas, Jose Roberto de Matos, José Salatiel Rodrigues Pires, Josi Fernanda Cerveira, Juan Ruiz-Esparza, Juliana Paulo da Silva, Juliano André Bogoni, Karina Theodoro Molina, Karla Dayane de Lima Pereira, Karoline Ceron, Kristel de Vleeschouwer, Laís Lautenschlager, Larissa Bailey, Larissa Fornitano, Lilian Elaine Rampim, Lorena Sforza, Luan Gonçalves Bissa, Luca Mattos Santucci, Lucas Gonçalves da Silva, Lucas Neves Perillo, Lucas Ribeiro Correa, Ludmila Hufnagel, Luis Fernando Alberti, Luis Jose Recalde Mello, Luis Renato Rezende Bernardo, Luiz Gustavo Rodrigues Oliveira-Santos, Luiza Neves Guimarães, Maíra Benchimol, Manuela Catharina Twardowschy, Marcela Ferreira-Riveros, Marcelo da Silva, Márcia Maria de Assis Jardim, Marco Aurélio Leite Fontes, Marcos Adriano Tortato, Marcos Tadeu do Nascimento, Margareth Lumy Sekiama, Maria Clara Nascimento-Costa, Maria Ester Bueno Dos Santos, Maria Santina de Castro Morini, Mariana Baldy Nagy-Reis, Mariane da Cruz Kaizer, Mariano José Ribeiro da Silva Sant'Anna, Marilia Teresinha Hartmann, Marina Ochoa Favarini, Marina Oliveira Olivo, Martín Alejandro Montes, Martin Roberto Del Valle Alvaréz, Matheus Feldstein Haddad, Maurício Djalles Costa, Maurício Eduardo Graipel, Mauricio Quoos Konzen, Mauro Galetti, Meyline de Oliveira Souza Almeida, Michel Barros Faria, Micheli Ribeiro Luiz, Michelle Noronha da Matta Baptista, Miguel Ângelo Marini, Milton Cezar Ribeiro, Natalie Olifiers, Natasha Moraes de Albuquerque, Nicolás Cantero, Nivaldo Peroni, Noeli Zanella, Olívia Mendonça-Furtado, Olivier Pays, Orlando Ednei Ferretti, Oscar Rocha-Barbosa, Paloma Marques Santos, Patrícia Menegaz de Farias, Patrício Adriano da Rocha, Paul François Colas-Rosas, Paula Ribeiro-Souza, Paula Ferracioli, Paulo Afonso Hartmann, Paulo de Tarso Zuquim Antas, Paulo Ribeiro, Paulo Tomasi Sarti, Paulo Ivo Mônico, Pedro Volkmer de Castilho, Peônia Brito de Moraes Pereira, Peter Gransden Crawshaw, Pierre-Cyril Renaud, Rafael Spilere Romagna, Rafael Turíbio Moraes de Sousa, Raíssa Soares Spagnol, Raone Beltrão-Mendes, Ravi Fernandes Mariano, Renata Reinoso Rocha, Renata Sousa-Lima, Renata Valls Pagotto, Rhayssa Terra de Faria, Ricardo Corassa Arrais, Ricardo Moratelli, Ricardo Sartorello, Rita de Cassia Bianchi, Roberto de Carvalho Guimarães, Rodrigo Lima Massara, Romulo Theodoro Costa, Rosane Vera Marques, Ruan Márcio Ruas Nunes, Sandra Maria Hartz, Saulo Meneses Silvestre de Sousa, Saulo Ramos Lima, Sergio Lutz Barbosa, Silvia Neri Godoy, Stephen Francis Ferrari, Talita Guimarães de Araújo-Piovezan, Talita Laura Góes, Tatiane Campos Trigo, Thales R O de Freitas, Thiago Bernardes Maccarini, Thiago Marcial de Castro, Thiago Ribas Bella, Tonny Marques de Oliveira Junior, Uslaine Maciel Cunha, Vanessa Tavares Kanaan, Vera Pfannerstill, Victor Siqueira Pimentel, Vilmar Picinatto Filho, Vinícius Nunes Alves, Viviana Rojas-Bonzi, Viviane Mottin, Vlamir José Rocha, Andreas Kindel, Igor Pfeifer Coelho
Camera traps became the main observational method of a myriad of species over large areas. Data sets from camera traps can be used to describe the patterns and monitor the occupancy, abundance, and richness of wildlife, essential information for conservation in times of rapid climate and land-cover changes. Habitat loss and poaching are responsible for historical population losses of mammals in the Atlantic Forest biodiversity hotspot, especially for medium to large-sized species. Here we present a data set from camera trap surveys of medium to large-sized native mammals (>1 kg) across the Atlantic Forest...
April 12, 2024: Ecology
#6
JOURNAL ARTICLE
Jason Cosgrove, Antoine Marçais, Felix J Hartmann, Andreas Bergthaler, Ivan Zanoni, Mauro Corrado, Leïla Perié, Nina Cabezas-Wallscheid, Philippe Bousso, Theodore Alexandrov, Tammy Kielian, Nuria Martínez-Martín, Christiane A Opitz, Costas A Lyssiotis, Rafael J Argüello, Jan Van den Bossche
No abstract text is available yet for this article.
April 11, 2024: Nature metabolism
#7
JOURNAL ARTICLE
Lucas Leal Fraga, Bruno Ramos Nascimento, Beatriz Costa Haiashi, Alexandre Melo Ferreira, Mauro Henrique Agapito Silva, Isabely Karoline da Silva Ribeiro, Gabriela Aparecida Silva, Wanessa Campos Vinhal, Mariela Mata Coimbra, Cássia Aparecida Silva, Cristiana Rosa Lima Machado, Magda C Pires, Marina Gomes Diniz, Luiza Pereira Afonso Santos, Arthur Maia Amaral, Lucas Chaves Diamante, Henrique Leão Fava, Craig Sable, Maria Carmo Pereira Nunes, Antonio Luiz P Ribeiro, Clareci Silva Cardoso
BACKGROUND: Tele-cardiology tools are valuable strategies to improve risk stratification. OBJECTIVE: We aimed to evaluate the accuracy of tele-electrocardiography (ECG) to predict abnormalities in screening echocardiography (echo) in primary care (PC). METHODS: In 17 months, 6 health providers at 16 PC units were trained on simplified handheld echo protocols. Tele-ECGs were recorded for final diagnosis by a cardiologist. Consented patients with major ECG abnormalities by the Minnesota code, and a 1:5 sample of normal individuals underwent clinical questionnaire and screening echo interpreted remotely...
2024: Arquivos Brasileiros de Cardiologia
#8
JOURNAL ARTICLE
Gianluca Costa, Giovanni Maria Garbarino, Luca Lepre, Gianluca Liotta, Gianluca Mazzoni, Alice Gabrieli, Alessandro Costa, Mauro Podda, Gabriele Sganga, Pietro Fransvea
Background: Peptic ulcers result from imbalanced acid production, and in recent decades, proton pump inhibitors have proven effective in treating them. However, perforated peptic ulcers (PPU) continue to occur with a persistent high mortality rate when not managed properly. The advantages of the laparoscopic approach have been widely acknowledged. Nevertheless, concerning certain technical aspects of this method, such as the best gastrorrhaphy technique, the consensus remains elusive. Consequently, the choice tends to rely on individual surgical experiences...
February 22, 2024: Journal of Clinical Medicine
#9
RANDOMIZED CONTROLLED TRIAL
Marcelo Carvalho Vieira, Fernanda de Souza Nogueira Sardinha Mendes, Paula Simplício da Silva, Gilberto Marcelo Sperandio da Silva, Flavia Mazzoli-Rocha, Andrea Silvestre de Sousa, Roberto Magalhães Saraiva, Marcelo Teixeira de Holanda, Daniel Arthur Barata Kasal, Henrique Silveira Costa, Juliana Pereira Borges, Michel Silva Reis, Luiz Fernando Rodrigues Junior, Alejandro Marcel Hasslocher-Moreno, Pedro Emmanuel Alvarenga Americano do Brasil, Mauro Felippe Felix Mediano
To investigate the effect of an exercise-based cardiac rehabilitation program on the quality of life (QoL) of patients with chronic Chagas cardiomyopathy (CCC). PEACH study was a single-center, superiority randomized clinical trial of exercise training versus no exercise (control). The sample comprised Chagas disease patients with CCC, left ventricular ejection fraction < 45%, without or with HF symptoms (CCC stages B2 or C, respectively). QoL was assessed at baseline, after three months, and at the end of six months of follow-up using the SF-36 questionnaire...
April 8, 2024: Scientific Reports
#10
JOURNAL ARTICLE
Andressa Rubim Lopes, Dennis Guilherme Costa Silva, Nathane Rosa Rodrigues, Illana Kemmerich Martins, Luana Paganotto Leandro, Mauro Eugênio Medina Nunes, Thais Posser, Jeferson Franco
Glutamate is one of the predominant excitatory neurotransmitters released from the central nervous system; however, at high concentrations, this substance may induce excitotoxicity. This phenomenon is involved in numerous neuropathologies. At present, clinically available pharmacotherapeutic agents to counteract glutamatergic excitotoxicity are not completely effective; therefore, research to develop novel compounds is necessary. In this study, the main objective was to determine the pharmacotherapeutic potential of the hydroalcoholic extract of Psidium guajava (PG) in a model of oxidative stress-induced by exposure to glutamate utilizing Danio rerio larvae (zebrafish) as a model...
April 4, 2024: Journal of Toxicology and Environmental Health. Part A
#11
REVIEW
Luiz Fernando Ferreira Pereira, Ricardo Sales Dos Santos, Daniel Oliveira Bonomi, Juliana Franceschini, Ilka Lopes Santoro, André Miotto, Thiago Lins Fagundes de Sousa, Rodrigo Caruso Chate, Bruno Hochhegger, Artur Gomes Neto, Airton Schneider, César Augusto de Araújo Neto, Dante Luiz Escuissato, Gustavo Faibischew Prado, Luciana Costa-Silva, Mauro Musa Zamboni, Mario Claudio Ghefter, Paulo César Rodrigues Pinto Corrêa, Pedro Paulo Teixeira E Silva Torres, Ricardo Kalaf Mussi, Valdair Francisco Muglia, Irma de Godoy, Wanderley Marques Bernardo
Although lung cancer (LC) is one of the most common and lethal tumors, only 15% of patients are diagnosed at an early stage. Smoking is still responsible for more than 85% of cases. Lung cancer screening (LCS) with low-dose CT (LDCT) reduces LC-related mortality by 20%, and that reduction reaches 38% when LCS by LDCT is combined with smoking cessation. In the last decade, a number of countries have adopted population-based LCS as a public health recommendation. Albeit still incipient, discussion on this topic in Brazil is becoming increasingly broad and necessary...
2024: Jornal Brasileiro de Pneumologia: Publicaça̋o Oficial da Sociedade Brasileira de Pneumologia e Tisilogia
#12
JOURNAL ARTICLE
Sivaram Emani, Kleydson Alves, Layana Costa Alves, Daiane Alves da Silva, Patricia Bartholomay Oliveira, Marcia C Castro, Ted Cohen, Rodrigo de Macedo Couto, Mauro Sanchez, Nicolas A Menzies
BACKGROUND: In Brazil, many individuals with tuberculosis (TB) do not receive appropriate care due to delayed or missed diagnosis, ineffective treatment regimens, or loss-to-follow-up. This study aimed to estimate the health losses and TB program costs attributable to each gap in the care cascade for TB disease in Brazil. METHODS AND FINDINGS: We constructed a Markov model simulating the TB care cascade and lifetime health outcomes (e.g., death, cure, postinfectious sequelae) for individuals developing TB disease in Brazil...
March 21, 2024: PLoS Medicine
#13
MULTICENTER STUDY
Won-Keun Kim, Moritz Seiffert, Andreas Rück, David M Leistner, Henryk Dreger, Hendrik Wienemann, Matti Adam, Helge Möllmann, Johannes Blumenstein, Clemens Eckel, Andrea Buono, Diego Maffeo, Antonio Messina, Andreas Holzamer, Samuel Sossalla, Giuliano Costa, Marco Barbanti, Silvia Motta, Corrado Tamburino, Ina von der Heide, Julius Glasmacher, Mohammad Sherif, Philipp Seppelt, Stephan Fichtlscherer, Thomas Walther, Fausto Castriota, Roberto Nerla, Christian Frerker, Tobias Schmidt, Alexander Wolf, Martin M Adamaszek, Francesco Giannini, Maarten Vanhaverbeke, Stefaan Van de Walle, Francis Stammen, Stefan Toggweiler, Stephanie Brunner, Antonio Mangieri, Mauro Gitto, Gerrit Kaleschke, Vlasis Ninios, Ilias Ninios, Judith Hübner, Erion Xhepa, Matthias Renker, Efstratios I Charitos, Michael Joner, Tobias Rheude
BACKGROUND: There is a lack of comparative data on transcatheter aortic valve implantation (TAVI) in degenerated surgical prostheses (valve-in-valve [ViV]). AIMS: We sought to compare outcomes of using two self-expanding transcatheter heart valve (THV) systems for ViV. METHODS: In this retrospective multicentre registry, we included consecutive patients undergoing transfemoral ViV using either the ACURATE neo/neo2 (ACURATE group) or the Evolut R/PRO/PRO+ (EVOLUT group)...
March 18, 2024: EuroIntervention
#14
JOURNAL ARTICLE
Clara Pinto Diniz, Mauro Felippe Felix Mediano, Luiz Fernando Rodrigues Junior, Fernanda de Souza Nogueira Sardinha Mendes, Roberto Magalhães Saraiva, Henrique Horta Veloso, Andréa Rodrigues da Costa, Alejandro Marcel Hasslocher-Moreno, Audrey Borghi-Silva, Andréa Silvestre de Sousa, Flavia Mazzoli-Rocha
OBJECTIVE: Inspiratory muscle strength (IMS) appears to be reduced in subjects with chronic Chagas heart disease (CHD), especially in the presence of heart failure (HF). However, only one study about IMS and inspiratory muscle endurance (IME) in those with CHD without heart failure is available. This study aimed to compare IMS and IME in subjects with CHD in the presence and absence of HF. METHODS: This is a cross-sectional study in which 30 CHD adult patients were divided into CHD-CC group (initial phase of CHD, without HF; n = 15) and CHD-HF group (advanced phase of CHD, with HF; n = 15)...
March 19, 2024: Tropical Medicine & International Health
#15
JOURNAL ARTICLE
Walison Nunes da Silva, Pedro Augusto Carvalho Costa, Sérgio Ricardo Aluotto Scalzo Júnior, Heloísa A S Ferreira, Pedro Henrique Dias Moura Prazeres, Caroline Leonel Vasconcelos Campos, Marco Túllio Rodrigues Alves, Natália Jordana Alves da Silva, Ana Luiza de Castro Santos, Lays Cordeiro Guimarães, Maria Eduarda Chen Ferris, Ajay Thatte, Alex Hamilton, Kelly Alves Bicalho, Anderson Oliveira Lobo, Helton da Costa Santiago, Lucíola da Silva Barcelos, Maria Marta Figueiredo, Mauro Martins Teixeira, Vivian Vasconcelos Costa, Michael J Mitchell, Frédéric Frézard, Pedro Pires Goulart Guimaraes
INTRODUCTION: Immunotherapy has revolutionized cancer treatment by harnessing the immune system to enhance antitumor responses while minimizing off-target effects. Among the promising cancer-specific therapies, tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) has attracted significant attention. METHODS: Here, we developed an ionizable lipid nanoparticle (LNP) platform to deliver TRAIL mRNA (LNP-TRAIL) directly to the tumor microenvironment (TME) to induce tumor cell death...
2024: International Journal of Nanomedicine
#16
JOURNAL ARTICLE
Piero Ruscitti, Francesco Masedu, Antonio Vitale, Valeria Caggiano, Ilenia Di Cola, Paola Cipriani, Marco Valenti, Henrique A Mayrink Giardini, Isabele Parente de Brito Antonelli, Marilia Ambiel Dagostin, Giuseppe Lopalco, Florenzo Iannone, Morrone Maria, Ibrahim A Almaghlouth, Kazi Nur Asfina, Hebatallah Hamed Ali, Francesco Ciccia, Daniela Iacono, Ilenia Pantano, Daniele Mauro, Petros P Sfikakis, Maria Tektonidou, Katerina Laskari, Onorina Berardicurti, Lorenzo Dagna, Alessandro Tomelleri, Abdurrahman Tufan, Rıza Can Kardas, Andrea Hinojosa-Azaola, Eduardo Martín-Nares, Perla Ayumi Kawakami-Campos, Gaafar Ragab, Mohamed Tharwat Hegazy, Haner Direskeneli, Fatma Alibaz-Oner, Lampros Fotis, Paolo Sfriso, Marcello Govoni, Francesco La Torre, Maria Cristina Maggio, Carlomaurizio Montecucco, Ludovico De Stefano, Serena Bugatti, Silvia Rossi, Joanna Makowska, Emanuela Del Giudice, Giacomo Emmi, Elena Bartoloni, José Hernández-Rodríguez, Giovanni Conti, Alma Nunzia Olivieri, Alberto Lo Gullo, Gabriele Simonini, Ombretta Viapiana, Ewa Wiesik-Szewczyk, Sukran Erten, Francesco Carubbi, Amato De Paulis, Armin Maier, Samar Tharwat, Stefania Costi, Annamaria Iagnocco, Gian Domenico Sebastiani, Antonio Gidaro, Antonio Luca Brucato, Anastasios Karamanakos, Nurullah Akkoç, Francesco Caso, Luisa Costa, Marcella Prete, Federico Perosa, Fabiola Atzeni, Giuliana Guggino, Claudia Fabiani, Bruno Frediani, Roberto Giacomelli, Luca Cantarini
OBJECTIVES: To evaluate the clinical usefulness of the systemic score in the prediction of life-threatening evolution in Still's disease. To assess the clinical relevance of each component of the systemic score in predicting life-threatening evolution and to derive patient subsets accordingly. METHODS: A multicenter, observational, prospective study was designed including patients included in the GIRRCS (Gruppo Italiano Di Ricerca in Reumatologia Clinica e Sperimentale) AOSD-study group and AIDA (AutoInflammatory Disease Alliance) Network Still's Disease Registry...
March 18, 2024: Arthritis & Rheumatology
#17
JOURNAL ARTICLE
Natália Teixeira Wnuk, André Felipe Almeida Figueiredo, Talita De Oliveira Farias, Marcos Rocha Gouvêa Brener, Samyra Maria Dos Santos Nassif Lacerda, Vidyleison Neves Camargos, Paulo Henrique Amaral, Lidia Maria Andrade, Maria Ivonete Nogueira Silva, Roberta Araujo Lopes, Raphael Escorsim Szawka, Juan Carlos González, Mauro Martins Teixeira, Danielle da Glória Souza, Vivian Vasconcelos Costa, Guilherme Mattos Jardim Costa
Infection with ZIKV during pregnancy is associated with fetal developmental problems. Although neurological issues are being explored more in experimental studies, limited research has focused on the reproductive health consequences for offspring born to infected mothers. In this context, this study aimed to assess the impact of ZIKV infection during pregnancy on the testes and sperm of adult male offspring. Female mice were intraperitoneally inoculated with a Brazil strain of ZIKV during the 5.5th day of embryonic gestation...
March 1, 2024: Reproduction
#18
JOURNAL ARTICLE
Jaqueline Pereira Lana, Marina Chaves de Oliveira, Ana Letícia Malheiros Silveira, Letícia Tamie Paiva Yamada, Kátia Anunciação Costa, Simone Vargas da Silva, Agatha de Assis-Ferreira, Emmanuel L Gautier, Sébastien Dussaud, Vanessa Pinho, Mauro Martins Teixeira, Geneviève Marcelin, Karine Clément, Adaliene Versiani Matos Ferreira
BACKGROUND/OBJECTIVES: Proinflammatory cytokines are increased in obese adipose tissue, including inflammasome key masters. Conversely, IL-18 protects against obesity and metabolic dysfunction. We focused on the IL-18 effect in controlling adipose tissue remodeling and metabolism. MATERIALS/SUBJECTS AND METHODS: We used C57BL/6 wild-type (WT) and interleukine-18 deficient (IL-18-/- ) male mice fed a chow diet and samples from bariatric surgery patients. RESULTS: IL-18-/- mice showed increased adiposity and proinflammatory cytokine levels in adipose tissue, leading to glucose intolerance...
March 8, 2024: International Journal of Obesity
#19
JOURNAL ARTICLE
Gonçalo Costa, César Teixeira, Mauro F Pinto
Epilepsy affects around 1% of the population worldwide. Anti-epileptic drugs are an excellent option for controlling seizure occurrence but do not work for around one-third of patients. Warning devices employing seizure prediction or forecasting algorithms could bring patients new-found comfort and quality of life. These algorithms would attempt to detect a seizure's preictal period, a transitional moment between regular brain activity and the seizure, and relay this information to the user. Over the years, many seizure prediction studies using Electroencephalogram-based methodologies have been developed, triggering an alarm when detecting the preictal period...
March 7, 2024: Scientific Reports
#20
JOURNAL ARTICLE
Acácio S de Souza, Deborah S Dias, Ruan C B Ribeiro, Dora C S Costa, Matheus G de Moraes, David R Pinho, Maria E G Masset, Laís M Marins, Sandy P Valle, Cláudio J C de Carvalho, Gustavo S G de Carvalho, Angélica Lauria N Mello, Mauro Sola-Penna, Marcos V Palmeira-Mello, Raissa A Conceição, Carlos R Rodrigues, Alessandra M T Souza, Luana da S M Forezi, Patricia Zancan, Vitor F Ferreira, Fernando de C da Silva
The search for novel anticancer drugs is essential to expand treatment options, overcome drug resistance, reduce toxicity, promote innovation, and tackle the economic impact. The importance of these studies lies in their contribution to advancing cancer research and enhancing patient outcomes in the battle against cancer. Here, we developed new asymmetric hybrids containing two different naphthoquinones linked by a 1,2,3-1H-triazole nucleus, which are potential new drugs for cancer treatment. The antitumor activity of the novel compounds was tested using the breast cancer cell lines MCF-7 and MDA-MB-231, using the non-cancer cell line MCF10A as control...
March 5, 2024: Bioorganic & Medicinal Chemistry
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