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Karishma S Furtado, Elizabeth L Budd, Xiangji Ying, Anna J deRuyter, Rebecca L Armstrong, Tahna L Pettman, Rodrigo S Reis, Pauline Sung-Chan, Zhaoxin Wang, Tahnee Saunders, Leonardo A Becker, Jianwei Shi, Long Sum Tabitha Mui, Ross C Brownson
Implementation of evidence-based practices can improve efficiency and effectiveness of public health efforts. Few studies have explored the political contextual factors that impact implementation of evidence-based non-communicable disease prevention (EBNCDP). This study aimed to do so in Australia, Brazil, China and the United States. Investigators conducted 10-13 qualitative, semi-structured interviews of public health practitioners working in functionally similar public health organizations in each country (total N = 50)...
March 14, 2018: Health Education Research
Sarah A Aroner, Manja Koch, Kenneth J Mukamal, Jeremy D Furtado, James H Stein, Matthew C Tattersall, Robyn L McClelland, Majken K Jensen
BACKGROUND: Apolipoprotein C-III (apoC-III), a small proinflammatory protein present on 6% to 7% of high-density lipoprotein (HDL) particles, defines a subspecies of HDL adversely associated with coronary heart disease in primarily white cohorts. In a multi-ethnic population free of clinical cardiovascular disease, we evaluated the relationship between apoC-III-defined HDL subspecies and subclinical markers of atherosclerotic pathology. METHODS AND RESULTS: We investigated cross-sectional associations between apolipoprotein A-I concentrations of apoC-III-defined HDL subspecies, measured via ELISA and imaging measures of subclinical atherosclerosis, among 4659 participants in the MESA (The Multi-Ethnic Study of Atherosclerosis) at baseline (2000-2002)...
March 14, 2018: Journal of the American Heart Association
Eduardo M Rocha, Monica Alves, João Marcello Furtado, Caio Regatieri
No abstract text is available yet for this article.
January 2018: Arquivos Brasileiros de Oftalmologia
Mery Natali Silva Abreu, Angela Deise Soares, Diemack Alle Oliveira Ramos, Fernanda Vieira Soares, Gerson Nunes Filho, Analina Furtado Valadão, Patrícia Gonçalves da Motta
Several studies have identified misconceptions about human papillomavirus (HPV), which can lead to negligent behavior and risk to the health of the population. This article aims to assess the knowledge of men and women about HPV in the city of Ipatinga, Minas Gerais, and evaluate socioeconomic factors and preventive measures associated with such knowledge. It involved a cross-sectional study with 591 subjects living in the city, by means of stratified sampling by quotas proportional to the number of individuals by sex and age in each of the eight administrative regions of the city...
March 2018: Ciência & Saúde Coletiva
Brenda Gasparini, Marcus Valadão, Adalberto Miranda-Filho, Cosme Marcelo Furtado Passos da Silva
The aim of this study was to estimate the contribution of the effect of age, period, and birth cohort on mortality from colorectal cancer. The study analyzed data on deaths from this cancer in individuals over 35 years of age in Rio de Janeiro State, Brazil, obtained from the Mortality Information System (SIM) from 1980 to 2014. Mortality rates were calculated by gender and age bracket. The effect of age, period, and birth cohort was estimated by the method that uses estimable functions: deviations, curves, and drift in the Epi library of the R software...
March 12, 2018: Cadernos de Saúde Pública
A Presotto, M P Verderane, L Biondi, O Mendonça-Furtado, N Spagnoletti, M Madden, P Izar
There is evidence that wild animals are able to recall key locations and associate them with navigational routes. Studies in primate navigation suggest most species navigate through the route network system, using intersections among routes as locations of decision-making. Recent approaches presume that points of directional change may be key locations where animals decide where to go next. Over four consecutive years, we observed how a wild group of bearded capuchin monkeys used a route network system and Change Point locations (CPs) in the Brazilian ecotone of Cerrado-Caatinga...
March 12, 2018: Animal Cognition
Isabela Cristina Cordeiro Farias, Taciana Furtado Mendonça-Belmont, Andreia Soares da Silva, Kleyton Palmeira do Ó, Felipe Ferreira, Fernanda Silva Medeiros, Luydson Richardson da Silva Vasconcelos, Marcos André Cavalcanti Bezerra, Aderson da Silva Araújo, Patricia Muniz Mendes Freire de Moura, Betânia Lucena Domingues Hatzlhofer, Ana Claudia Mendonça Dos Anjos, Maria do Socorro de Mendonça Cavalcanti
The SOD2 polymorphism Val16Ala T→C influences the antioxidative response. This study investigated the association of the SOD2 polymorphism and superoxide dismutase (SOD) activity with the vaso-occlusive crisis (VOC) and acute splenic sequestration (ASS) in children with sickle cell anemia (SCA). One hundred ninety-five children with SCA aged 1-9 years old were analyzed. The TC and CC genotypes were associated with lower SOD activity compared with the TT genotype (p=0.0321; p=0.0253, respectively). Furthermore, TC and CC were more frequent in patients with VOC or ASS (p=0...
2018: Mediterranean Journal of Hematology and Infectious Diseases
Corey C Foster, Andrew Y Lee, Larissa V Furtado, John Hart, Lindsay Alpert, Shu-Yuan Xiao, Neil H Hyman, Manish R Sharma, Stanley Liauw
BACKGROUND: Intensity-modulated radiation therapy (IMRT) has been used to limit treatment-related toxicity for patients with anal squamous cell carcinoma (SCC). The treatment outcomes and HPV characteristics for a cohort of patients receiving definitive concurrent chemotherapy and IMRT are reported. MATERIALS AND METHODS: 52 patients with anal SCC were treated with IMRT and concurrent chemotherapy. Radiation was delivered sequentially to the pelvis and inguinal lymph nodes (45 Gy) and anal tumor (median dose, 54 Gy)...
2018: PloS One
Hue T M Tran, Thiruvarangan Ramaraj, Agnelo Furtado, L Slade Lee, Robert J Henry
Arabica coffee (Coffea arabica) has a small gene pool limiting genetic improvement. Selection for caffeine content within this gene pool would be assisted by identification of the genes controlling this important trait. Sequencing of DNA bulks from 18 genotypes with extreme high or low caffeine content from a population of 232 genotypes was used to identify linked polymorphisms. To obtain a reference genome a whole genome assembly of arabica coffee (variety K7) was achieved by sequencing using short read (Illumina) and long read (PacBio) technology...
March 6, 2018: Plant Biotechnology Journal
Daniele Furtado-Albanezi, Soraia Pilon Jürgensen, Mariana Arias Avila, Grasiela Nascimento Correia, Patricia Driusso
INTRODUCTION AND HYPOTHESIS: The objective was to check the effects of two nonpharmacological treatments on the sleep quality of women with nocturia. METHODS: A randomized controlled clinical trial in which 40 women with nocturia were randomized into two groups; one was subjected to tibial nerve stimulation (GTNS) and the other received pelvic floor muscle training associated with behavioral therapy (GPFMT). Both groups were followed for 12 weeks, with one session/week; evaluated by the Pittsburgh Sleep Quality Index (PSQI), King's Heath Questionnaire (KHQ), and Epworth Sleepiness Scale (ESS)...
March 6, 2018: International Urogynecology Journal
Jamie Perin, Gregory Prokopowicz, Margaret Furtado, Konstantinos Papas, Kimberley E Steele
BACKGROUND: Vitamin and mineral deficiencies are common following Roux-en-Y gastric bypass (RYGB) and can lead to significant morbidity, but little research on the efficacy of vitamin supplementation regimens exists. We compared the efficacy and tolerability of an investigational versus a standard multivitamin regimen in patients undergoing RYGB. METHODS: Fifty-six patients, aged 18 to 65, were randomized to an investigational versus a standard multivitamin. Plasma levels of vitamins A, B-12, D, E-α, E-β/γ, thiamine, folate, iron, iron-binding capacity, iron saturation, prealbumin, and parathyroid hormone (PTH) were measured at 3 and 6 months postoperatively...
March 2, 2018: Obesity Surgery
Corrine Hanson, Elizabeth Lyden, Jeremy Furtado, Matthew Van Ormer, Marina Schumacher, Ammar Kamil, Elizabeth McGinn, Katherine Rilett, Elizabeth Elliott, Caleb Cave, Rebecca Johnson, Kara Weishaar, Ann Anderson-Berry
BACKGROUND: Oxidative stress has been associated with adverse neonatal outcomes, and vitamin E has powerful anti-oxidant properties. Vitamin E occurs in several different isoforms which differ in their ability to modulate inflammation and oxidative stress. Therefore, the purpose of this study was to evaluate the status of α-, γ- and δ-tocopherol in maternal-infant pairs, and the impact on maternal-newborn outcomes. METHODS: Vitamin E status was evaluated in 189 mother-infant pairs...
February 20, 2018: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
José Ivan Marques, Jovelina Samara Ferreira Alves, Manoela Torres-Rêgo, Allanny Alves Furtado, Emerson Michell da Silva Siqueira, Eder Galinari, Daline Fernandes de Souza Araújo, Gerlane Coelho Bernardo Guerra, Eduardo Pereira de Azevedo, Matheus de Freitas Fernandes-Pedrosa, Silvana Maria Zucolotto
Tabernaemontana catharinensis (Apocynaceae) has been popularly used by folk medicine because of its anti-inflammatory, analgesic, and antiophidic properties. This study aims to analyze the flavonoids composition of the hydroethanolic extract and of the ethyl acetate (EtOAc) and butanol (BuOH) fractions of T. catharinensis leaves, as well as to evaluate their anti-inflammatory activity using in vivo models. The phytochemical profile, determined by High-Performance Liquid Chromatography-High-Resolution Electrospray Ionization-Mass Spectrometry (HPLC-HRESI-MS), showed the presence of flavonoids mainly having an isorhamnetin nucleus...
February 24, 2018: International Journal of Molecular Sciences
Jesús Vergara-Temprado, Annette K Miltenberger, Kalli Furtado, Daniel P Grosvenor, Ben J Shipway, Adrian A Hill, Jonathan M Wilkinson, Paul R Field, Benjamin J Murray, Ken S Carslaw
Large biases in climate model simulations of cloud radiative properties over the Southern Ocean cause large errors in modeled sea surface temperatures, atmospheric circulation, and climate sensitivity. Here, we combine cloud-resolving model simulations with estimates of the concentration of ice-nucleating particles in this region to show that our simulated Southern Ocean clouds reflect far more radiation than predicted by global models, in agreement with satellite observations. Specifically, we show that the clouds that are most sensitive to the concentration of ice-nucleating particles are low-level mixed-phase clouds in the cold sectors of extratropical cyclones, which have previously been identified as a main contributor to the Southern Ocean radiation bias...
February 28, 2018: Proceedings of the National Academy of Sciences of the United States of America
Rui Miguel Martins, João Soeiro Teodoro, Emanuel Furtado, Anabela Pinto Rolo, Carlos Marques Palmeira, José Guilherme Tralhão
Ischemia/reperfusion (I/R) injury in liver transplantation can disrupt the normal activity of mitochondria in the hepatic parenchyma. This potential dysfunction of mitochondria after I/R injury could be responsible for the initial poor graft function or primary nonfunction observed after liver transplantation. Thus, determining the mechanisms that lead to human hepatic mitochondrial dysfunction might contribute to improving the outcome of liver transplantation. Furthermore, early identification of novel prognostic factors involved in I/R injury could serve as a key endpoint to predict the outcome of liver grafts and also to promote the early adoption of novel strategies that protect against I/R injury...
2018: International Journal of Medical Sciences
Talita A Comunian, Marina Nogueira, Bianca Scolaro, Marcelo Thomazini, Roselayne Ferro-Furtado, Inar Alves de Castro, Carmen S Favaro-Trindade
Intake of omega-3 fatty acids and phytosterols aids in the reduction of cholesterol and serum triglycerides. However, both fatty acids and phytosterols are susceptible to oxidation. This work coencapsulated echium oil (source of stearidonic and alpha-linolenic fatty acids) and beta-sitosterol (phytosterol) by complex coacervation using different combinations of wall materials, and sinapic acid (SA) and transglutaminase as crosslinkers. High encapsulation yields were obtained (29-93% for SA; 68-100% for the mixture of oil and phytosterols) and retention of 49-99% and 16% for encapsulated and free SA, at 30 days-storage...
June 30, 2018: Food Chemistry
Abhishek Biswas, Marino E Leon, Peter Drew, Sebastian Fernandez-Bussy, Larissa V Furtado, Michael A Jantz, Hiren J Mehta
BACKGROUND: Pembrolizumab was recently approved as a first line agent for metastatic NSCLC in patients with high programmed death-ligand 1 (PD-L1) expression. OBJECTIVES: Since a significant portion of lung cancer is diagnosed by endobronchial ultrasound-guided transbronchial needle aspiration (EBUS TBNA); there is a need for PD-L1 testing in these specimens. However, to date few studies have evaluated performance of cytology specimens from EBUS TBNA for PD-L1 analysis...
February 24, 2018: Diagnostic Cytopathology
Matheus Uba Chupel, Luciele Guerra Minuzzi, Guilherme E Furtado, Mário Leonardo Santos, Eef Hogervorst, Edith Filaire, Ana Maria Teixeira
Immunosenescence contribute to increase the blood-brain barrier (BBB) permeability, leading cognitive impairment and neurodegeneration. Thus, we investigated the anti-inflammatory effect of exercise and taurine supplementation on peripheral markers of blood-brain barrier, inflammation, and cognition of elderly women. Forty-eight elderly women (83.58±6.9 years) participated in the study, and were allocated into combined exercise training (CET: n=13), taurine supplementation (TAU: n=12), exercise training associated with taurine (CET+TAU: n=11), or control group (CG: n=12)...
February 23, 2018: Applied Physiology, Nutrition, and Metabolism, Physiologie Appliquée, Nutrition et Métabolisme
Robson Xavier Faria, Daniel Tadeu Gomes Gonzaga, Paulo Anastácio Furtado Pacheco, André Luis Almeida Souza, Vitor Francisco Ferreira, Fernando de Carvalho da Silva
Chagas disease is one of the most relevant endemic diseases in Latin America caused by the flagellate protozoan Trypanosoma cruzi. Nifurtimox and benzonidazole are the drugs used in the treatment of this disease, but they commonly are toxic and present severe side effects. New effective molecules, without collateral effects, has promoted the investigation to develop new lead compounds with to advance for clinical trials. Previously, 3-nitro-1H-1,2,4-triazole-based amines and 1,2,3-triazoles demonstrated significant trypanocidal activity against T...
February 23, 2018: Journal of Bioenergetics and Biomembranes
E Furtado da Luz, J U Braga
SETTING: According to World Health Organization (WHO) estimates, the under-reporting rate for tuberculosis (TB) in Cape Verde between 2006 and 2012 was 49%. However, the WHO recognises the challenges associated with this estimation process and recommends implementing other methods, such as record linkage, to combat TB under-reporting. OBJECTIVES: To estimate and analyse under-reporting of cases by TB surveillance health units and to evaluate TB cases retrieved from other TB diagnostic sources in Praia, Cape Verde, from 2006 to 2012...
March 1, 2018: International Journal of Tuberculosis and Lung Disease
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