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https://www.readbyqxmd.com/read/29351246/addition-of-berberine-to-preservation-solution-in-an-animal-model-of-ex-vivo-liver-transplant-preserves-mitochondrial-function-and-bioenergetics-from-the-damage-induced-by-ischemia-reperfusion
#1
Rui Miguel Martins, Anabela Pinto Rolo, João Soeiro Teodoro, Emanuel Furtado, Rui Caetano Oliveira, José Guilherme Tralhão, Carlos Marques Palmeira
Liver transplantation is a therapeutic regimen to treat patients with non-malignant end-stage liver diseases and malignant tumors of hepatic origin. The ischemia/reperfusion (I/R) injury in liver transplantation is associated with disruption of mitochondrial function in the hepatic parenchyma. Several studies have been conducted in animal models to identify pharmacological therapeutic strategies to minimize the injury induced by the cold/warm I/R in liver transplantation. Most of these studies were conducted in unrealistic conditions without the potential to be translated to clinical usage...
January 19, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29343840/vision-status-in-older-adults-the-brazilian-amazon-region-eye-survey
#2
Solange R Salomão, Adriana Berezovsky, João M Furtado, Arthur G Fernandes, Sergio Muñoz, Nívea N Cavascan, Marcela C Cypel, Cristina C Cunha, Galton C Vasconcelos, Márcia R K H Mitsuhiro, Paula Y Sacai, Mauro Campos, Paulo H A Morales, Marcos J Cohen, Jacob M Cohen, Sung E S Watanabe, Rubens Belfort
Older adults living in remote areas with limited access to health services are at higher risk to develop visual impairment and blindness. We conducted a population-based survey to determine the vision status in subjects 45 years of age and older from urban and rural areas of Parintins city, Brazilian Amazon Region. Participants underwent ophthalmic examination, including uncorrected (UCVA), presenting (PVA) and best-corrected visual acuity (BCVA). Vision status was described as lines of visual acuity (VA) impairment and lines of VA improvement from UCVA to BCVA and from PVA to BCVA in the better-seeing eye...
January 17, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29340461/synanthropic-triatomines-as-potential-vectors-of-trypanosoma-cruzi-in-central-brazil
#3
Thaís Tâmara Castro Minuzzi-Souza, Nadjar Nitz, César Augusto Cuba Cuba, Marcelo Santalucia, Monique Knox, Luciana Hagström, Camilla Bernardes Furtado, Tamires Emanuele Vital, Marcos Takashi Obara, Mariana Machado Hecht, Rodrigo Gurgel-Gonçalves
INTRODUCTION: Chagas disease surveillance requires current knowledge on synanthropic triatomines. We analyzed the occurrence and Trypanosoma cruzi infection rates of triatomine bugs in central Brazil, during 2012-2014. METHODS: Triatomines were collected inside or around houses, and T. cruzi infection was determined by optical microscopy and conventional/quantitative polymerase chain reaction. RESULTS: Of the 2706 triatomines collected, Triatoma sordida was the most frequent species in Goiás State, whereas Panstrongylus megistus predominated in the Federal District...
November 2017: Revista da Sociedade Brasileira de Medicina Tropical
https://www.readbyqxmd.com/read/29336615/pharmacokinetic-bioequivalence-safety-and-acceptability-of-ornibel%C3%A2-a-new-polymer-composition-contraceptive-vaginal-ring-etonogestrel-ethinylestradiol-11-00-3-474%C3%A2-mg-compared-with-nuvaring%C3%A2-etonogestrel-ethinylestradiol-11-7-2-7%C3%A2-mg
#4
Jaime Algorta, Maria Diaz, Raquel de Benito, Marc Lefebvre, Eric Sicard, Milton Furtado, Pedro Antonio Regidor, Celestino Ronchi
OBJECTIVE: To show the clinical development of Ornibel® (ExeltisHealthcare, Spain) a contraceptive vaginal ring manufactured with a new polymer composition and containing etonogestrel/ethinylestradiol, compared to Nuvaring® (MSD, Spain). SUBJECTS AND METHODS: Randomised, single dose, 2-period, 2-sequence, 2-stage crossover, comparative bioavailability study conducted in 40 healthy female subjects. All subjects received both treatments for 28 days in each of two periods, separated by a 28 days washout...
January 16, 2018: European Journal of Contraception & Reproductive Health Care
https://www.readbyqxmd.com/read/29330722/location-of-low-copy-genes-in-chromosomes-of-brachiaria-spp
#5
Thaís Furtado Nani, James C Schnable, Jacob D Washburn, Patrice Albert, Welison Andrade Pereira, Fausto Souza Sobrinho, James A Birchler, Vânia Helena Techio
Repetitive DNA sequences have been widely used in cytogenetic analyses. The use of gene sequences with a low-copy-number, however, is little explored especially in plants. To date, the karyotype details in Brachiaria spp. are limited to the location of rDNA sites. The challenge lies in developing new probes based on incomplete sequencing data for the genus or complete sequencing of related species, since there are no model species with a sequenced genome in Brachiaria spp. The present study aimed at the physical location of conserved genes in chromosomes of Brachiaria ruziziensis, Brachiaria brizantha, and Brachiaria decumbens using RNAseq data, as well as sequences of Setaria italica and Sorghum bicolor through the fluorescent in situ hybridization technique...
January 12, 2018: Molecular Biology Reports
https://www.readbyqxmd.com/read/29324946/realities-and-perspectives-of-adolescent-mothers-in-their-first-pregnancy
#6
Rita de Cássia Andrade Neiva Santos, Raimunda Magalhães da Silva, Maria Veraci Oliveira Queiroz, Herla Maria Furtado Jorge, Aline Veras Morais Brilhante
OBJECTIVE: to understand the trajectory of adolescents regarding the first pregnancy, contemplating realities and perspectives. METHOD: qualitative study, based on the Schütz theoretical framework, with 30 adolescents assisted in an outpatient clinic for adolescents in Fortaleza, Ceará, Brazil. From the narrative interviews carried out in the first semester of 2013, in the return for the first consultation of the puerperium, the communicative processes were identified, the central ideas and units of meanings expressed in the themes were abstracted: I was dating and became pregnant; realities and perspectives...
January 2018: Revista Brasileira de Enfermagem
https://www.readbyqxmd.com/read/29300307/chemical-composition-and-bioactivity-of-essential-oil-from-blepharocalyx-salicifolius
#7
Fabiana Barcelos Furtado, Bruna Cristina Borges, Thaise Lara Teixeira, Hans Garcia Garces, Luiz Domingues de Almeida Junior, Fernanda Cristina Bérgamo Alves, Claudio Vieira da Silva, Ary Fernandes Junior
Natural products represent a source of biologically active molecules that have an important role in drug discovery. The aromatic plant Blepharocalyx salicifolius has a diverse chemical constitution but the biological activities of its essential oils have not been thoroughly investigated. The aims of this paper were to evaluate in vitro cytotoxic, antifungal and antibacterial activities of an essential oil from leaves of B. salicifolius and to identify its main chemical constituents. The essential oil was extracted by steam distillation, chemical composition was determined by gas chromatography/mass spectrometry, and biological activities were performed by a microdilution broth method...
January 4, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29286883/antifungal-activities-against-toxigenic-fusarium-specie-and-deoxynivalenol-adsorption-capacity-of-ion-exchanged-zeolites
#8
Geovana D Savi, William A Cardoso, Bianca G Furtado, Tiago Bortolotto, Elton T Zanoni, Rahisa Scussel, Lucas F Rezende, Ricardo A Machado-de-Ávila, Oscar R K Montedo, Elidio Angioletto
Zeolites are often used as adsorbents materials and their loaded cations can be exchanged with metal ions in order to add antimicrobial properties. The aim of this study was to use the 4A zeolite and its derived ion-exchanged forms with Zn2+, Li+, Cu2+ and Co2+ in order to evaluate their antifungal properties against Fusarium graminearum, including their capacity in terms of metal ions release, conidia germination and the deoxynivalenol (DON) adsorption. The zeolites ion-exchanged with Li+, Cu2+, and Co2+ showed an excellent antifungal activity against F...
December 29, 2017: Journal of Environmental Science and Health. Part. B, Pesticides, Food Contaminants, and Agricultural Wastes
https://www.readbyqxmd.com/read/29277980/investigating-cross-contamination-by-yeast-strains-from-dental-solid-waste-to-waste-handling-workers-by-dna-sequencing
#9
Cristina Dutra Vieira, Thaysa Leite Tagliaferri, Maria Auxiliadora Roque de Carvalho, Maria Aparecida de Resende-Stoianoff, Rodrigo Assuncao Holanda, Thais Furtado Ferreira de Magalhães, Paula Prazeres Magalhães, Simone Gonçalves Dos Santos, Luiz de Macêdo Farias
Trying to widen the discussion on the risks associated with dental waste, this study proposed to investigate and genetically compare yeast isolates recovered from dental solid waste and waste workers. Three samples were collected from workers' hands, nasal mucosa, and professional clothing (days 0, 30, and 180), and two from dental waste (days 0 and 180). Slide culture, microscopy, antifungal drug susceptibility, intersimple sequence repeat analysis, and amplification and sequencing of internal transcribed spacer regions were performed...
December 26, 2017: MicrobiologyOpen
https://www.readbyqxmd.com/read/29277564/feasibility-of-endobronchial-ultrasound-guided-transbronchial-needle-aspiration-cytology-specimens-for-next-generation-sequencing-in-non-small-cell-lung-cancer
#10
Sean P Stoy, Jeremy P Segal, Jeffrey Mueller, Larissa V Furtado, Everett E Vokes, Jyoti D Patel, Septimiu Murgu
INTRODUCTION: Next generation sequencing (NGS) testing of lung cancer is recommended by guidelines, and endobronchial ultrasound (EBUS)-guided transbronchial needle aspiration (TBNA) often provides the only material available for testing. Previous studies have demonstrated successful NGS testing on cell block samples obtained by EBUS; however, cytology smears provide a more reliable sample with better DNA quality for testing. In this study, we aimed to determine the success rate of OncoScreen (50 gene) and OncoPlus (1213 gene) panel NGS testing of cytology samples obtained by EBUS utilizing 22- and 25-gauge needles...
December 5, 2017: Clinical Lung Cancer
https://www.readbyqxmd.com/read/29276172/dysbiosis-associated-change-in-host-metabolism-generates-lactate-to-support-salmonella-growth
#11
Caroline C Gillis, Elizabeth R Hughes, Luisella Spiga, Maria G Winter, Wenhan Zhu, Tatiane Furtado de Carvalho, Rachael B Chanin, Cassie L Behrendt, Lora V Hooper, Renato L Santos, Sebastian E Winter
During Salmonella-induced gastroenteritis, mucosal inflammation creates a niche that favors the expansion of the pathogen population over the microbiota. Here, we show that Salmonella Typhimurium infection was accompanied by dysbiosis, decreased butyrate levels, and substantially elevated lactate levels in the gut lumen. Administration of a lactate dehydrogenase inhibitor blunted lactate production in germ-free mice, suggesting that lactate was predominantly of host origin. Depletion of butyrate-producing Clostridia, either through oral antibiotic treatment or as part of the pathogen-induced dysbiosis, triggered a switch in host cells from oxidative metabolism to lactate fermentation, increasing both lactate levels and Salmonella lactate utilization...
December 15, 2017: Cell Host & Microbe
https://www.readbyqxmd.com/read/29261785/correction-microrna-profiling-of-the-effect-of-the-heptapeptide-angiotensin-1-7-in-a549-lung-tumor-cells-reveals-a-role-for-mirna149-3p-in-cellular-migration-processes
#12
Brenda de Oliveira da Silva, Kelvin Furtado Lima, Letícia Rocha Gonçalves, Marina Bonfogo da Silveira, Karen C M Moraes
[This corrects the article DOI: 10.1371/journal.pone.0162094.].
2017: PloS One
https://www.readbyqxmd.com/read/29247901/temporal-distribution-of-suicide-mortality-a-systematic-review
#13
REVIEW
Pauliana Valéria Machado Galvão, Hugo Rafael Souza E Silva, Cosme Marcelo Furtado Passos da Silva
BACKGROUND: suicide is a problem with world impact and the leading cause of premature deaths. The study of its distribution over time can bring a changed understanding of parameters attributed to, and the prevention of, suicide. AIM: to identify the temporal pattern of suicide by systematic review. METHODS: Pubmed (Medline), LILACS, Virtual Health Library (VHL), Science Direct and Scopus (Elsevier), Web of Science (Thomson Reuters) and PsyNET (APA) were searched, using suicide-related descriptors and terms, for observational epidemiological studies of the temporal distribution of suicide...
December 7, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29242128/performance-of-5-different-displays-in-the-detection-of-artificial-incipient-and-recurrent-caries-like-lesions
#14
Shawn Chancy Countryman, Saulo Leonardo Sousa Melo, Manuella Dias Furtado Belem, Francisco Haiter-Neto, Marcos A Vargas, Veeratrishul Allareddy
OBJECTIVES: The aim of this study was to assess whether auto-calibrating medical-grade monitors perform better than off-the-shelf monitors and tablet computers in detecting artificial incipient and recurrent caries-like lesions. STUDY DESIGN: Sixty extracted teeth (30 premolars and 30 molars) were selected. All molars received class II amalgam and composite restorations. A 7-mm2 area on the crowns of half of the teeth was demineralized. Phantoms consisting of 4 teeth were created...
November 15, 2017: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
https://www.readbyqxmd.com/read/29238857/fto-rs9939609-a-allele-influences-anthropometric-outcome-in-response-to-dietary-intervention-but-not-in-response-to-physical-exercise-program
#15
Gabrielle Araujo do Nascimento, Mayza Dalcin Teixeira, Lupe Furtado-Alle, Neiva Leite, Ricardo Lehtonen Rodrigues de Souza, Louise Farah Saliba, Gerusa Eisfeld Milano, Larissa Rosa da Silva, Juliana Pizzi, Wendell Arthur Lopes, Maria de Fátima Aguiar Lopes, Ana Cláudia Kapp Titski, Luciane Viater Tureck
PURPOSE: The fat mass and obesity-associated (FTO) gene is involved in energy homeostasis. The A allele of the rs9939609 (SNP; T>A) is associated with obesity and higher food intake, while its effect in energy expenditure remains unclear. The aim of this study is to examine whether FTO rs9939609 is associated with the anthropometric outcomes of a physical exercise program and a dietary intervention. METHODS: We studied two independent samples. The first was composed by children and adolescents in which overweight and obese individuals were submitted to a physical exercise program (n = 136) and normal weight participants served as a control group (n = 172)...
December 13, 2017: European Journal of Nutrition
https://www.readbyqxmd.com/read/29238390/modulatory-effect-of-association-of-brain-stimulation-by-light-and-binaural-beats-in-specific-brain-waves
#16
Mauricio Rocha Calomeni, Vernon Furtado da Silva, Bruna Brandão Velasques, Olavo Guimarães Feijó, Juliana Marques Bittencourt, Alair Pedro Ribeiro de Souza E Silva
Introduction: One of the positive effects of brain stimulation is interhemispheric modulation as shown in some scientific studies. This study examined if a type of noninvasive stimulation using binaural beats with led-lights and sound would show different modulatory effects upon Alfa and SMR brain waves of elderlies and children with some disease types. Subjects: The sample included 75 individuals of both genders, being, randomly, divided in 6 groups. Groups were named elderly without dementia diagnosis (EWD), n=15, 76±8 years, elderly diagnosed with Parkinson's disease (EDP), n=15, 72±7 years, elderly diagnosed with Alzheimer's disease (EDA), n=15, 81±6 years...
2017: Clinical Practice and Epidemiology in Mental Health: CP & EMH
https://www.readbyqxmd.com/read/29237662/advanced-abdominal-pregnancy-in-a-spontaneous-heterotopic-pregnancy
#17
Nuno Maciel, Ana Furtado Lima, Rosa Cruz, Carlos Ponte
Spontaneous heterotopic pregnancy is a potentially life-threatening condition rarely considered when a patient with an intrauterine pregnancy is asymptomatic or presents with complaints such as abdominal pain. An advanced abdominal pregnancy as the form of the ectopic component, outside the context of assisted reproduction, is an even more unusual and perilous diagnosis with very few cases reported in the literature. We report such a case in a 34-year-old multipara, with no known risk factors for ectopic pregnancy...
December 13, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/29236892/joinville-stroke-biobank-study-protocol-and-first-year-s-results
#18
Leslie Ecker Ferreira, Paulo Henrique Condeixa de França, Vivian Nagel, Vanessa Venancio, Juliana Safanelli, Felipe Ibiapina Dos Reis, Luis Furtado, Rui Kleber Martins, Gustavo Weiss, Elder Oda, Iscia Lopes-Cendes, Octavio Pontes-Neto, Norberto Luiz Cabral
Aiming to contribute to studies that use detailed clinical and genomic information of biobanks, we present the initial results of the first Latin American Stroke Biobank. METHODS: Blood samples were collected from patients included in the Joinville Stroke Registry and four Brazilian cities. Demographic socio-economic data, cardiovascular risk factors, Causative Classification System for Ischemic Stroke, Trial of Org 10172 in Acute Stroke Treatment and National Institutes of Health scores, functional stroke status (modified Rankin) and brain images were recorded...
December 2017: Arquivos de Neuro-psiquiatria
https://www.readbyqxmd.com/read/29234755/self-etching-enamel-bonding-using-acidic-functional-monomers-with-different-length-carbon-chains-and-hydrophilicity
#19
Viviane Hass, Gabriel Abuna, Victor Pinheiro Feitosa, Eveline Claudia Martini, Mario Alexandre Sinhoreti, Roberta Furtado Carvalho, Matheus Coelho Bandéca, Salvatore Sauro, Alessandro D Loguercio
PURPOSE: To compare the enamel bonding performace of two commercial and three experimental two-step self-etch adhesives containing acidic functional monomers with different carbon-spacer length and hydrophilicity. The contact angle was also assessed to evaluate the wettability of each tested material. MATERIALS AND METHODS: Forty extracted human molars were sectioned into four parts (buccal, lingual, mesial, and distal) and divided into 5 groups, according to the adhesives used: Clearfil SE Bond (CSE), AdheSE (ADSE), 10-MDP (15 mol% 10-methacryloyldecylphosphate), CAP-P (15 mol% caprolactone phosphate), and MTEP (15 mol% methacryloyltetraethylene phosphate)...
December 12, 2017: Journal of Adhesive Dentistry
https://www.readbyqxmd.com/read/29231055/effect-of-anatomical-region-on-the-formation-of-metal-artifacts-produced-by-dental-implants-in-cone-beam-computed-tomographic-images
#20
Alessiana Helena Machado, Karolina Aparecida Castilho Fardim, Camila Furtado de Souza, Bruno Salles Sotto-Maior, Neuza Maria Souza Picorelli Assis, Karina Lopes Devito
OBJECTIVES: To quantitatively compare metal artifacts produced by implants in different maxillomandibular regions on cone beam computed tomography (CBCT) images. METHODS: A total of 200 implants selected from CBCT examinations were divided into four groups: Group 1 (n = 50) - implants located in the anterior maxilla; Group 2 (n = 50) - implants located in the posterior maxilla; Group 3 (n = 50) - implants located in the anterior mandible; and Group 4 (n = 50) - implants located in the posterior mandible...
December 12, 2017: Dento Maxillo Facial Radiology
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