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https://www.readbyqxmd.com/read/28088491/toxicogenetic-study-of-persea-americana-fruit-pulp-oil-and-its-effect-on-genomic-instability
#1
Heloiza Diniz Nicolella, Francisco Rinaldi Neto, Mariana Beltrame Corrêa, Danillo Henrique Lopes, Edilaura Nunes Rondon, Luiz Felipe Ribeiro Dos Santos, Pollyanna Francielli de Oliveira, Jaqueline Lopes Damasceno, Nathália Oliveira Acésio, Izabel Cristina Casanova Turatti, Marcos Gomide Tozatti, Wilson Roberto Cunha, Ricardo Andrade Furtado, Denise Crispim Tavares
Persea americana Mill., commonly known as avocado, is a tree native to Central America that is widely used as a food source and for the treatment of diseases. This plant has various biological properties such as analgesic, anti-inflammatory and total cholesterol-lowering activity. In view of its pharmacological potential, we conducted a toxicogenetic study of the fruit pulp oil of P. americana (PAO) and investigated its influence on genotoxicity induced by methyl methanesulfonate (MMS) and doxorubicin. V79 cells and Swiss mice were used for the assays...
January 11, 2017: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/28088105/tectona-grandis-leaf-extract-free-and-associated-with-nanoemulsions-as-a-possible-photosensitizer-of-mouse-melanoma-b16-cell
#2
Cydia de Menezes Furtado, Fernando Sergio Escocio Drumond Viana de Faria, Ricardo Bentes Azevedo, Karen Py-Daniel, Ana Lygia Dos Santos Camara, Jaqueline Rodriguez da Silva, Everton de Holanda Oliveira, Anselmo Fortunato Ruiz Rodriguez, Igor Anatolievich Degterev
Over the past six years we have been studying extracts from tropical, specially Amazon, plants, to search for new sensitizers for photodynamic therapy of cancer and infectious diseases. Tectona grandis is a genus of tropical hardwood trees in the mint family, Lamiaceae. That is native to south and southeast Asia, but since the end of the 20th century is also gaining ground in the Amazon. The present work aims to evaluate the photodynamic potential of hydro-alcoholic extract from Tectona grandis LF leaves (TGE) and the same extract prepared as the oil-water nanoemulsion (TGE-NE) against melanoma B16 F10 cells...
January 5, 2017: Journal of Photochemistry and Photobiology. B, Biology
https://www.readbyqxmd.com/read/28076643/translation-and-cross-cultural-adaptation-of-the-rating-scale-for-countertransference-rsct-to-american-english
#3
Rafael Mondrzak, Camila Reinert, Andreia Sandri, Lucas Spanemberg, Eduardo L Nogueira, Mirella Bertoluci, Claudio Laks Eizirik, Nina Rosa Furtado
Introduction: The Rating Scale for Countertransference (RSCT) - originally, Escala para Avaliação de Contratransferência (EACT) - is a self-administered instrument comprising questions that assess 23 feelings (divided into three blocs, closeness, distance, and indifference) that access conscious countertransferential emotions and sentiments. This paper describes the process of translation and cross-cultural adaptation of the RSCT into American English. Methods: This study employed the guidelines proposed by the International Society for Pharmacoeconomics and Outcomes Research (ISPOR) Task Force for Translation and Cultural Adaptation which define 10 steps for translation and cross-cultural adaptation of self-report instruments...
October 2016: Trends in Psychiatry and Psychotherapy
https://www.readbyqxmd.com/read/28070763/uveitis-in-childhood-onset-systemic-lupus-erythematosus-patients-a-multicenter-survey
#4
Paola Pinheiro Kahwage, Mariana Paes Leme Ferriani, João M Furtado, Luciana Martins de Carvalho, Gecilmara Salviato Pileggi, Francisco Hugo Rodrigues Gomes, Maria Teresa Terreri, Claudia Saad Magalhães, Rosa Maria Rodrigues Pereira, Silvana Brasilia Sacchetti, Roberto Marini, Eloisa Bonfá, Clovis Artur Silva, Virgínia Paes Leme Ferriani
The aim of this study is to assess uveitis prevalence in a large cohort of childhood-onset systemic lupus erythematosus (cSLE) patients. A retrospective multicenter cohort study including 852 cSLE patients was performed in ten pediatric rheumatology centers (Brazilian cSLE group). An investigator meeting was held and all participants received database training. Uveitis was diagnosed through clinical assessment by the uveitis expert ophthalmologist of each center. Patients with and without uveitis were assessed for lupus clinical/laboratory features and treatments...
January 9, 2017: Clinical Rheumatology
https://www.readbyqxmd.com/read/28069747/a-targeted-rnai-screen-identifies-factors-affecting-diverse-stages-of-receptor-mediated-transcytosis
#5
Bradlee Nelms, Natasha Furtado Dalomba, Wayne Lencer
Endosome transport by transcytosis is the primary mechanism by which proteins and other large cargo traverse epithelial barriers in normal tissue. Transcytosis is also essential for establishing and maintaining membrane polarity in epithelia and other polarized cells. To identify novel components of this pathway, we conducted a high-throughput RNA interference screen for factors necessary for the bidirectional transcytosis of IgG by the Fcγ receptor FcRn. This screen identified 23 genes whose suppression resulted in a reproducible decrease in FcRn-mediated transcytosis...
January 9, 2017: Journal of Cell Biology
https://www.readbyqxmd.com/read/28062095/the-liver-transcriptome-of-suckermouth-armoured-catfish-pterygoplichthys-anisitsi-loricariidae-identification-of-expansions-in-defensome-gene-families
#6
Thiago E Parente, Daniel A Moreira, Maithê G P Magalhães, Paula C C de Andrade, Carolina Furtado, Brian J Haas, John J Stegeman, Mark E Hahn
Pterygoplichthys is a genus of related suckermouth armoured catfishes native to South America, which have invaded tropical and subtropical regions worldwide. Physiological features, including an augmented resistance to organic xenobiotics, may have aided their settlement in foreign habitats. The liver transcriptome of Pterygoplichthys anisitsi was sequenced and used to characterize the diversity of mRNAs potentially involved in the responses to natural and anthropogenic chemicals. In total, 66,642 transcripts were assembled...
January 3, 2017: Marine Pollution Bulletin
https://www.readbyqxmd.com/read/28017859/antiparasitic-activity-of-menadione-vitamin-k3-against-schistosoma-mansoni-in-babl-c-mice
#7
Govind J Kapadia, Ingrid A O Soares, G Subba Rao, Fernanda R Badoco, Ricardo A Furtado, Mariana B Correa, Denise C Tavares, Wilson R Cunha, Lizandra G Magalhães
Schistosomiasis is one of the neglected tropical diseases affecting nearly quarter of a billion people in economically challenged tropical and subtropical countries of the world. Praziquantel (PZQ) is the only drug currently available to treat this parasitic disease in spite being ineffective against juvenile worms and concerns about developing resistance to treat reinfections. Our earlier in vitro viability studies demonstrated significant antiparasitic activity of menadione (MEN) (vitamin K3) against Schistosoma mansoni adult worms...
December 23, 2016: Acta Tropica
https://www.readbyqxmd.com/read/28008590/the-effectiveness-of-anticholinergic-therapy-for-overactive-bladders-systematic-review-and-meta-analysis
#8
Andrea Moura Rodrigues Maciel da Fonseca, Mariana Furtado Meinberg, Marilene Vale de Castro Monteiro, Matheus Roque, Jorge Milhen Haddad, Rodrigo Aquino Castro
The overactive bladder (OAB) has a significant negative impact on the quality of life of patients. Antimuscarinics have become the pharmacological treatment of choice for this condition. The objective of this systematic review and meta-analysis is to examine the evidence from randomized clinical trials about the outcomes of the antimuscarinic drugs available in Brazil on OABs. We searched MEDLINE and the Cochrane Central Register of Controlled Trials from the inception of these databases through to September 2015...
November 2016: Revista Brasileira de Ginecologia e Obstetrícia
https://www.readbyqxmd.com/read/28003757/results-of-a-venous-thromboembolism-prophylaxis-program-for-hospitalized-patients
#9
Luiz Francisco Cardoso, Daniella Vianna C Krokoscz, Edison Ferreira de Paiva, Ilka Spinola Furtado, Jorge Mattar, Marcia Martiniano de Souza E Sá, Antonio Carlos Onofre de Lira
INTRODUCTION: Venous thromboembolism (VTE) is the leading cause of preventable death in hospitalized patients. However, existing prophylaxis guidelines are rarely followed. OBJECTIVE: The aim of the study was to present and discuss implementation strategies and the results of a VTE prophylaxis program for medical and surgical patients admitted to a large general hospital. PATIENTS AND METHODS: This prospective observational study was conducted to describe the strategy used to implement a VTE prophylaxis program in hospitalized medical and surgical patients and to analyze the results in terms of the risk assessment rate within the first 24 hours after admission, adequacy of the prophylaxis prescription, and prevalence of VTE in the discharge records before and after program implementation...
2016: Vascular Health and Risk Management
https://www.readbyqxmd.com/read/28002457/terrorism-radicalisation-extremism-authoritarianism-and-fundamentalism-a-systematic-review-of-the-quality-and-psychometric-properties-of-assessments
#10
Akimi Scarcella, Ruairi Page, Vivek Furtado
BACKGROUND: Currently, terrorism and suicide bombing are global psychosocial processes that attracts a growing number of psychological and psychiatric contributions to enhance practical counter-terrorism measures. The present study is a systematic review that explores the methodological quality reporting and the psychometric soundness of the instruments developed to identify risk factors of terrorism, extremism, radicalisation, authoritarianism and fundamentalism. METHOD: A systematic search strategy was established to identify instruments and studies developed to screen individuals at risk of committing extremist or terrorist offences using 20 different databases across the fields of law, medicine, psychology, sociology and politics...
2016: PloS One
https://www.readbyqxmd.com/read/28000475/effect-of-grape-juice-consumption-on-antioxidant-activity-and-interleukin-6-concentration-in-lactating-rats
#11
Sabrina Baptista Alves Faria, Vanessa Rosse, Juliana Furtado Dias, Nara Moreira Xavier, Vilma Blondet Azeredo
OBJECTIVE: This study evaluated the effect of grape juice consumption on the antioxidant capacity and the interleukin-6 blood level of lactating rats. MATERIAL AND METHOD: Eighteen Wistar rats, lactating females adult, were divided into two groups: control group (CG) and grape juice group (GJG). The antioxidant activity was determined by the method of 2,2-diphenyl-1-picrylhydrazyl (DPPH)-kidnapping of free radicals (DPPH) and oxygen radical absorbance capacity (ORAC), and the interleukin-6 was determined by Enzyme-Linked Immunosorbent Assay (ELISA) method...
November 29, 2016: Nutrición Hospitalaria: Organo Oficial de la Sociedad Española de Nutrición Parenteral y Enteral
https://www.readbyqxmd.com/read/28000452/phase-angle-and-onodera-s-prognostic-nutritional-index-in-critically-ill-patients
#12
Karina Marques Vermeulen, Leilane Lilian Araújo Leal, Mariana Câmara Martins Bezerra Furtado, Sancha Helena de Lima Vale, Lúcia Leite Lais
INTRODUCTION: Assessing severity and nutritional prognosis in critical patients has become increasingly important in recent years, since these parameters are related to morbidity/mortality and used to guide therapeutic options. OBJECTIVE: Determine nutritional prognosis through the Phase Angle (PA) and Onodera's Prognostic Nutritional Index (OPNI) and its relationship with severity, hospitalization time and mortality of critically ill patients. METHODS: Descriptive cross-sectional study, involving adult patients hospitalized in an Intensive Care Unit (ICU)...
November 29, 2016: Nutrición Hospitalaria: Organo Oficial de la Sociedad Española de Nutrición Parenteral y Enteral
https://www.readbyqxmd.com/read/27989409/the-burden-of-ionizing-radiation-studies-in-children-with-ventricular-shunts
#13
Maria C Antonucci, Noel S Zuckerbraun, Elizabeth C Tyler-Kabara, Andre D Furtado, Meghan E Murphy, Jennifer R Marin
OBJECTIVES: To quantify the number of shunt-related imaging studies that patients with ventricular shunts undergo and to calculate the proportion of computed tomography (CT) scans associated with a surgical intervention. STUDY DESIGN: Retrospective longitudinal cohort analysis of patients up to age 22 years with a shunt placed January 2002 through December 2003 at a pediatric hospital. Primary outcome was the number of head CT scans, shunt series radiograph, skull radiographs, nuclear medicine, and brain magnetic resonance imaging studies for 10 years following shunt placement...
December 15, 2016: Journal of Pediatrics
https://www.readbyqxmd.com/read/27988505/quality-indicators-in-laboratory-medicine-the-status-of-the-progress-of-ifcc-working-group-laboratory-errors-and-patient-safety-project
#14
Laura Sciacovelli, Giuseppe Lippi, Zorica Sumarac, Jamie West, Isabel Garcia Del Pino Castro, Keila Furtado Vieira, Agnes Ivanov, Mario Plebani
The knowledge of error rates is essential in all clinical laboratories as it enables them to accurately identify their risk level, and compare it with those of other laboratories in order to evaluate their performance in relation to the State-of-the-Art (i.e. benchmarking) and define priorities for improvement actions. Although no activity is risk free, it is widely accepted that the risk of error is minimized by the use of Quality Indicators (QIs) managed as a part of laboratory improvement strategy and proven to be suitable monitoring and improvement tools...
December 19, 2016: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/27982292/2-nd-brazilian-consensus-on-chagas-disease-2015
#15
João Carlos Pinto Dias, Alberto Novaes Ramos, Eliane Dias Gontijo, Alejandro Luquetti, Maria Aparecida Shikanai-Yasuda, José Rodrigues Coura, Rosália Morais Torres, José Renan da Cunha Melo, Eros Antonio de Almeida, Wilson de Oliveira, Antônio Carlos Silveira, Joffre Marcondes de Rezende, Fabiane Scalabrini Pinto, Antonio Walter Ferreira, Anis Rassi, Abílio Augusto Fragata, Andréa Silvestre de Sousa, Dalmo Correia, Ana Maria Jansen, Glaucia Manzan Queiroz Andrade, Constança Felícia De Paoli de Carvalho Britto, Ana Yecê das Neves Pinto, Anis Rassi, Dayse Elisabeth Campos, Fernando Abad-Franch, Silvana Eloi Santos, Egler Chiari, Alejandro Marcel Hasslocher-Moreno, Eliane Furtado Moreira, Divina Seila de Oliveira Marques, Eliane Lages Silva, José Antonio Marin-Neto, Lúcia Maria da Cunha Galvão, Sergio Salles Xavier, Sebastião Aldo da Silva Valente, Noêmia Barbosa Carvalho, Alessandra Viana Cardoso, Rafaella Albuquerque E Silva, Veruska Maia da Costa, Simone Monzani Vivaldini, Suelene Mamede Oliveira, Vera da Costa Valente, Mayara Maia Lima, Renato Vieira Alves
Chagas disease is a neglected chronic condition with a high burden of morbidity and mortality. It has considerable psychological, social, and economic impacts. The disease represents a significant public health issue in Brazil, with different regional patterns. This document presents the evidence that resulted in the Brazilian Consensus on Chagas Disease. The objective was to review and standardize strategies for diagnosis, treatment, prevention, and control of Chagas disease in the country, based on the available scientific evidence...
December 2016: Revista da Sociedade Brasileira de Medicina Tropical
https://www.readbyqxmd.com/read/27982205/microbiological-and-epidemiological-study-of-infectious-keratitis-in-children-and-adolescents
#16
Maria Cecilia Zorat Yu, Ana Luisa Höfling-Lima, Guilherme Henrique Campos Furtado
Purpose: To analyze epidemiological and microbiological aspects of microbial keratitis in children and adolescents. Methods: This retrospective cohort study was conducted at the Department of Ophthalmology and Visual Science, Escola Paulista de Medicina, Universidade Federal de São Paulo, between July 15, 1975, and December 31, 2010. We analyzed corneal samples from 859 patients with clinical suspicion of infectious keratitis, comparing epidemiological and microbiological characteristics of bacterial keratitis with those of non-bacterial and non-viral keratitis...
September 2016: Arquivos Brasileiros de Oftalmologia
https://www.readbyqxmd.com/read/27974989/inflammatory-myofibroblastic-tumor-of-the-bladder-2-rare-cases-managed-with-laparoscopic-partial-cystectomy
#17
Sofia Santos Lopes, Andrea Furtado, Rita Oliveira, Ana Cebola, Bruno Graça, Manuel Ferreira Coelho, Fernando Ferrito, Carrasquinho Gomes
Two cases of inflammatory myofibroblastic tumor (IMT) of the bladder are reported here. Both patients were male and presented with macroscopic hematuria; in the first case terminal hematuria was associated with irritative voiding symptoms. The second case was a smoker with hematuria unresponsive to medical treatment and anemia. Clinical presentation, pathological features, treatment, and prognosis are discussed. Due to rarity of this pathological condition, there are no guidelines concerning treatment and follow-up...
2016: Case Reports in Urology
https://www.readbyqxmd.com/read/27974977/total-cad-cam-supported-method-for-manufacturing-removable-complete-dentures
#18
Arthur Furtado de Mendonça, Mario Furtado de Mendonça, George Shelby White, Georges Sara, Darren Littlefair
The incorporation of computer-aided design/computer-aided manufacturing (CAD/CAM) technology into complete denture fabrication brings about several advantages to the fabrication process, providing better predictability of the desired outcomes and high accuracy of denture fit, mainly because the milling of prepolymerized acrylic resin eliminates the shrinkage of the acrylic base. Also, there is a decrease in the porosity when compared to a conventionally processed denture, and consequently there is a decrease in the retention of Candida albicans on the denture base...
2016: Case Reports in Dentistry
https://www.readbyqxmd.com/read/27955981/high-solids-emulsions-produced-by-ultrasound-as-a-function-of-energy-density
#19
Larissa Consoli, Guilherme de Figueiredo Furtado, Rosiane Lopes da Cunha, Míriam Dupas Hubinger
The use of emulsifying methods is frequently required before spray drying food ingredients, where using high concentration of solids increases the drying process yield. In this work, we used ultrasound to obtain kinetically stable palm oil-in-water emulsions with 30g solids/100g of emulsion. Sodium caseinate, maltodextrin and dried glucose syrup were used as stabilizing agents. Sonication time of 3, 7 and 11min were evaluated at power of 72, 105 and 148W (which represents 50%, 75% and 100% of power amplitude in relation to the nominal power of the equipment)...
December 1, 2016: Ultrasonics Sonochemistry
https://www.readbyqxmd.com/read/27933488/effects-of-economic-recession-on-elderly-patients-perceptions-of-access-to-health-care-and-medicines-in-portugal
#20
Filipa Alves da Costa, Inês Teixeira, Filipa Duarte-Ramos, Luís Proença, Ana Rita Pedro, Cristina Furtado, José Aranda da Silva, José Cabrita
Background In view of the current financial and demographic situation in Portugal, accessibility to health care may be affected, including the ability to adhere to medication. Objective To evaluate the perceived effects of the crisis on elderly patient's access to medicines and medical care, and its implications on medicine-taking behaviour. Setting Community pharmacy. Method A cross-sectional study was undertaken during April 2013, where elderly patients answered a self-administered questionnaire based on their health-related experiences in the current and previous year...
December 9, 2016: International Journal of Clinical Pharmacy
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