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https://www.readbyqxmd.com/read/28523408/genetics-and-epigenetics-of-varicocele-pathophysiology-an-overview
#1
REVIEW
Viviane Paiva Santana, Cristiana Libardi Miranda-Furtado, Flavia Gaona de Oliveira-Gennaro, Rosana Maria Dos Reis
Varicocele is found in approximately 20% of adults and adolescents and in 19-41% of men seeking treatment for infertility. It is associated with a decrease in sperm count as well as sperm motility and morphology. The currently accepted description of the pathophysiology of varicocele does not explain all its clinical manifestations; therefore, other factors such as genetic and epigenetic changes, associated with the environment, might be involved in causing infertility and decrease in sperm quality. It has been reported that the varicocele-induced deterioration of testicular function is progressive and interferes with fertility; hence, early and efficient assessment of the genetic manifestations in patients would be important for developing future medical interventions...
May 18, 2017: Journal of Assisted Reproduction and Genetics
https://www.readbyqxmd.com/read/28522704/draft-genome-sequence-of-metschnikowia-australis-strain-ufmg-cm-y6158-an-extremophile-marine-yeast-endemic-to-antarctica
#2
Thiago M Batista, Heron O Hilário, Rennan G Moreira, Carolina Furtado, Valéria M Godinho, Luiz H Rosa, Glória R Franco, Carlos A Rosa
Here we report the draft genome sequence of Metschnikowia australis strain UFMG-CM-Y6158, a yeast endemic to Antarctica. We isolated the strain from the marine seaweed Acrosiphonia arcta (Chlorophyta). The genome is 14.3 Mb long and contains 4,442 predicted protein-coding genes.
May 18, 2017: Genome Announcements
https://www.readbyqxmd.com/read/28520887/apolipoprotein-c-iii-and-high-density-lipoprotein-subspecies-defined-by-apolipoprotein-c-iii-in-relation-to-diabetes-risk
#3
Sarah A Aroner, Ming Yang, Junlong Li, Jeremy D Furtado, Frank M Sacks, Anne Tjønneland, Kim Overvad, Tianxi Cai, Majken K Jensen
Apolipoprotein C-III (apoC-III) is a potential novel biomarker that may play an important role in the pathogenesis of diabetes, particularly when present on high-density lipoprotein (HDL). In a case-cohort design among 3,101 non-cases and 434 incident diabetes cases occurring before 2007 in the Danish Diet, Cancer, and Health study, we examined associations of baseline (1993-1997) plasma concentrations of apoC-III and subspecies of HDL defined by the presence or absence of apoC-III with risk of diabetes using Cox regression...
May 18, 2017: American Journal of Epidemiology
https://www.readbyqxmd.com/read/28516356/morphology-ultrastructure-and-element-uptake-in-calophyllum-brasiliense-cambess-calophyllaceae-j-agardh-seedlings-under-cadmium-exposure
#4
Alezania Silva Pereira, Priscila Andressa Cortez, Alex-Alan Furtado de Almeida, Majeti Narashima Vara Prasad, Marcel Giovanni Costa França, Maura da Cunha, Raildo Mota de Jesus, Pedro Antônio Oliveira Mangabeira
Cadmium (Cd) is a metal known for its genotoxicity and cytotoxicity, much concerned for its potential environmental and human health impacts. This study evaluates the toxic effect of Cd in Calophyllum brasiliense plants. The plants were cultivated for 30 days in full nutrient solution in order to adapt, and for 15 days in nutrient solution without Cd or with 4, 8, 16, and 32 μmol Cd L(-1). Anatomical analysis of the leaf showed no significant effects of Cd on epidermal thickness in abaxial and adaxial sides, palisade, and spongy parenchyma...
May 17, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28512279/antimicrobial-potential-of-plant-extracts-and-chemical-fractions-of-sideroxylon-obtusifolium-roem-schult-t-d-penn-on-oral-microorganisms
#5
Thaíse Pd Sampaio, Nathália Ao Cartaxo-Furtado, Ana Cd de Medeiros, Harley S Alves, Pedro L Rosalen, Jozinete V Pereira
AIM: The aim of this study is to evaluate the in vitro antimicrobial activity of plant extracts and chemical fractions of Sideroxylon obtusifolium T.D. Penn on Streptococcus mutans, Streptococcus oralis, Streptococcus salivarius, Streptococcus parasanguinis, and Candida albicans as well as to identify the chemical classes found in the bioactive extracts possessing better activity. MATERIALS AND METHODS: Freeze-dried hydroalcoholic extracts of the bark and leaves (LC and LF respectively) and ethanol extracts of bark and leaves (EC and EF respectively) of S...
May 1, 2017: Journal of Contemporary Dental Practice
https://www.readbyqxmd.com/read/28511054/synthesis-and-in-vitro-anticancer-activity-of-new-2-thioxo-oxazolidin-4-one-derivatives
#6
Júlia Furtado Campos, Michelly Cristiny Pereira, Wanessa Layssa Batista de Sena, Caio Gomes de Barros Martins, Jamerson Ferreira de Oliveira, Cezar Augusto da Cruz Amorim, Moacyr Jesus Barreto de Melo Rêgo, Marina Galdino da Rocha Pitta, Maria do Carmo Alves de Lima, Maira Galdino da Rocha Pitta, Ivan da Rocha Pitta
BACKGROUND: Oxazolidinones derivatives exhibit different biological properties, including anticancer activity. This work aimed to investigate the anticancer potential of five novel 2-Thioxo-oxazolidin-4-one derivatives. METHODS: Cytotoxicity assays were performed in human peripheral blood mononuclear cells (PBMCs) from healthy individuals and seven tumor cell lines. Apoptosis detection and cell cycle were evaluated by flow cytometry and the expression of genes involved in cell death processes by Real-Time PCR...
March 18, 2017: Pharmacological Reports: PR
https://www.readbyqxmd.com/read/28504037/plasma-butyrylcholinesterase-activity-a-possible-biomarker-for-differential-diagnosis-between-alzheimer-s-disease-and-dementia-with-lewy-bodies
#7
N D Josviak, M S Batistela, R K M Souza, N R Wegner, G F Bono, C D Sulzbach, D P Simão-Silva, M R Piovezan, R L R Souza, L Furtado-Alle
Butyrylcholinesterase (BChE) is an enzyme encoded by BCHE gene, responsible for catalyzing the hydrolysis of acetylcholine. K and -116A BCHE variants were associated with decrease in plasma BChE activity, and their influence has been investigated in diseases with a cholinergic deficit such as Alzheimer's disease (AD) and dementia with Lewy bodies (DLB). In order to check the influence of BCHE genetic variants on enzymatic activity, all patients and controls were genotyped for K and -116A variants. We found lower plasma BChE activity in DLB patients compared to elderly controls and to AD independent of the presence of K or -116A variants...
May 15, 2017: International Journal of Neuroscience
https://www.readbyqxmd.com/read/28499072/sequencing-of-bulks-of-segregants-allows-dissection-of-genetic-control-of-amylose-content-in-rice
#8
Peterson Wambugu, Marie-Noelle Ndjiondjop, Agnelo Furtado, Robert Henry
Amylose content (AC) is a key quality trait in rice. A cross between Oryza glaberrima (African rice) and Oryza sativa (Asian rice) segregating for AC was analyzed by sequencing bulks of individuals with high and low AC. SNP associated with the granule bound starch synthase (GBSS1) locus on chromosome 6 were polymorphic between the bulks. In particular a G/A SNP that would result in an Asp to Asn mutation was identified. This amino acid substitution may be responsible for differences in GBSS activity as it is adjacent to a disulphide linkage conserved in all grass GBSS proteins...
May 12, 2017: Plant Biotechnology Journal
https://www.readbyqxmd.com/read/28498502/real-time-three-dimensional-jaw-tracking-in-temporomandibular-disorders
#9
Danilo Vieira da Cunha, Viviane Veroni Degan, Mário Vedovello Filho, Douglas Peres Bellomo, Marlete Ribeiro Silva, Daniel Antônio Furtado, Adriano Oliveira Andrade, Selma Terezinha Milagre, Adriano Alves Pereira
When a dysfunction occurs in any component of the stomatognathic system, temporomandibular disorders (TMD) may originates. The aim of this study was to compare the deviations, displacement, and the execution speed of mandibular movements among asymptomatic participants and those with TMD. Convenience sampling was used; forty participants diagnosed by clinical evaluation following the Research Diagnostic Criteria for Temporomandibular Disorders were divided into three groups: Arthropathy (GART, 10 participants, 40% men), Myopathy (GMYO, 10 participants, 30% men), and the Control Group (CG, 20 asymptomatic-participants, 25% men)...
May 12, 2017: Journal of Oral Rehabilitation
https://www.readbyqxmd.com/read/28497838/effect-of-bche-single-nucleotide-polymorphisms-on-lipid-metabolism-markers-in-women
#10
Jéssica de Oliveira, Luciane Viater Tureck, Willian Dos Santos, Louise Farah Saliba, Caroline Schovanz Schenknecht, Débora Scaraboto, Ricardo Lehtonen R Souza, Lupe Furtado-Alle
Butyrylcholinesterase (BChE) activity and polymorphisms in its encoding gene had previously been associated with metabolic traits of obesity. This study investigated the association of three single nucleotide polymorphisms (SNPs) in the BCHE gene: -116G > A (rs1126680), 1615GA (rs1803274), 1914A < G (rs3495), with obesity and lipid metabolism markers, body mass index (BMI), total cholesterol (TC), low density lipoprotein cholesterol (LDL-C), high density lipoprotein cholesterol (HDL-C), triglyceride (TG) levels, and BChE enzymatic activity in obese (BMI≥30/n = 226) and non-obese women (BMI < 25/n = 81)...
May 11, 2017: Genetics and Molecular Biology
https://www.readbyqxmd.com/read/28497228/18-des-hydroxy-cytochalasin-an-antiparasitic-compound-of-diaporthe-phaseolorum-92c-an-endophytic-fungus-isolated-from-combretum-lanceolatum-pohl-ex-eichler
#11
Elson Rudimar Brissow, Igor Pereira da Silva, Kátia Aparecida de Siqueira, Jaqueline Alves Senabio, Leticia Pereira Pimenta, Ana Helena Januário, Lizandra Guidi Magalhães, Ricardo Andrade Furtado, Denise Crispim Tavares, Policarpo Ademar Sales Junior, Jane Lima Santos, Marcos Antônio Soares
Chemical investigation of the ethyl acetate extract from the endophytic fungus Diaporthe phaseolorum-92C (92C) isolated from the roots of Combretum lanceolatum led to the isolation of 18-des-hydroxy Cytochalasin H (compound 1). The trypanocidal and schistosomicidal activity and cytotoxicity of the extract from 92C were evaluated. The schistosomicidal, leishmanicidal, antimicrobial, and antioxidant actions, as well as the antitumor activity against the breast cancer cells MDA-MB-231 and MCF-7, and the cytotoxicity towards normal human lung fibroblasts GM07492A of compound 1 was tested...
May 12, 2017: Parasitology Research
https://www.readbyqxmd.com/read/28496366/factors-associated-with-psychological-distress-among-young-women-in-kisumu-kenya
#12
Deborah A Gust, Roman Gvetadze, Melissa Furtado, Mumbi Makanga, Victor Akelo, Kenneth Ondenge, Beatrice Nyagol, Eleanor McLellan-Lemal
BACKGROUND: Attention to mental health issues is growing globally. In many countries, including Kenya, however, assessment of psychological distress, especially in rural areas, is limited. METHODS: We analyzed data from young women screened for a longitudinal contraceptive ring study in Kisumu, Kenya. Multivariable regression analysis was used to assess factors associated with recent moderate and high psychological distress, as measured by the Kessler (K-6) psychological distress scale...
2017: International Journal of Women's Health
https://www.readbyqxmd.com/read/28477349/cytological-and-cytomorphometric-evaluation-of-the-oral-mucosa-in-hiv-infected-patients-undergoing-antiretroviral-therapy
#13
Mônica Ghislaine Oliveira Alves, Celina Faig Lima Carta, Adriana Aigotti Haberbeck Brandão, Juvencio José Duailibe Furtado, Marcelo Marcucci, Janete Dias Almeida
BACKGROUND: To evaluate HIV infection-induced alterations in the oral mucosa by comparing inflammation, cell maturation and cytomorphometric changes in oral mucosal cells between HIV-infected patients undergoing highly active antiretroviral therapy (HAART) and non-HIV-infected patients. \ METHODS: Thirty HIV-infected patients undergoing HAART and 30 non-HIV-infected patients were studied. Four smears were obtained from the lateral border of the tongue and floor of the mouth with a cytobrush...
May 6, 2017: Journal of Oral Pathology & Medicine
https://www.readbyqxmd.com/read/28476857/apolipoprotein-a-ii-alters-the-proteome-of-human-lipoproteins-and-enhances-cholesterol-efflux-from-abca1
#14
John T Melchior, Scott E Street, Allison B Andraski, Jeremy D Furtado, Frank M Sacks, Rebecca L Shute, Emily I Greve, Debi K Swertfeger, Hailong Li, Amy S Shah, L Jason Lu, W Sean Davidson
High density lipoproteins (HDL) are a heterogeneous family of particles that vary in size, composition and function. The structure of most HDL is maintained by two scaffold proteins, apolipoprotein (apo)A-I and apoA-II, but up to 95 other accessory proteins have been found associated with the particles. Recent evidence suggests these accessory proteins are distributed across various subspecies and drive specific biological functions. Unfortunately, our understanding of the molecular composition of such subspecies is limited...
May 5, 2017: Journal of Lipid Research
https://www.readbyqxmd.com/read/28474322/%C3%AE-tcp-ha-with-or-without-enamel-matrix-proteins-for-maxillary-sinus-floor-augmentation-a-histomorphometric-analysis-of-human-biopsies
#15
James Carlos Nery, Luís Antônio Violin Dias Pereira, George Furtado Guimarães, Cassio Rocha Scardueli, Fabiana Mantovani Gomes França, Rubens Spin-Neto, Andreas Stavropoulos
BACKGROUND: It is still unclear whether enamel matrix proteins (EMD) as adjunct to bone grafting enhance bone healing. This study compared histomorphometrically maxillary sinus floor augmentation (MSFA) with β-TCP/HA in combination with or without EMD in humans. METHODS: In ten systemically healthy patients needing bilateral MSFA, one side was randomly treated using β-TCP/HA mixed with EMD (BC + EMD) and the other side using only β-TCP/HA (BC). After 6 months, biopsies were harvested from grafted areas during implant installation, being histologically and histomorphometrically analyzed...
December 2017: International Journal of Implant Dentistry
https://www.readbyqxmd.com/read/28472937/reducing-the-information-gap-on-loricarioidei-siluriformes-mitochondrial-genomics
#16
Daniel Andrade Moreira, Paulo Andreas Buckup, Carolina Furtado, Adalberto Luis Val, Renata Schama, Thiago Estevam Parente
BACKGROUND: The genetic diversity of Neotropical fish fauna is underrepresented in public databases. This distortion is evident for the order Siluriformes, in which the suborders Siluroidei and Loricarioidei share equivalent proportion of species, although far less is known about the genetics of the latter clade, endemic to the Neotropical Region. Recently, this information gap was evident in a study about the structural diversity of fish mitochondrial genomes, and hampered a precise chronological resolution of Siluriformes...
May 4, 2017: BMC Genomics
https://www.readbyqxmd.com/read/28460920/heteroaggregation-of-lipid-droplets-coated-with-sodium-caseinate-and-lactoferrin
#17
Guilherme de Figueiredo Furtado, Mariano Michelon, Davi Rocha Bernardes de Oliveira, Rosiane Lopes da Cunha
Formation and characterization of droplet heteroaggregates were investigated by mixing two emulsions previously stabilized by proteins oppositely charged. Emulsions were composed of 5vol.% of sunflower oil and 95vol.% of sodium caseinate or lactoferrin aqueous dispersions. They were produced using ultrasound with fixed power (300W) and sonication time (6min). Different volume ratios (0-100%) of sodium caseinate-stabilized emulsion (droplet diameter around 1.75μm) to lactoferrin-stabilized emulsion (droplet diameter around 1...
November 2016: Food Research International
https://www.readbyqxmd.com/read/28457389/beliefs-of-nursing-professionals-in-the-organ-donation-process-for-transplantation
#18
M J Dos Santos, M S Martins, V L Mira, E C D A Meireles, E L de Moraes, M S Cavenaghi, F C B R Miname, M C S C P Furtado, J A B Silva, A M R de Paula, B A Lemes, T E O Aquarelli
BACKGROUND: This study sought to discover the beliefs of nursing professionals in the organ donation process and to establish a relationship between the training and the beliefs of these professionals. METHODS: This was a quantitative and exploratory study composed of 611 nursing professionals. The sample characteristics and the response frequencies were presented through the use of descriptive statistics. The Kruskal-Wallis test was used to evaluate the different results between the professional categories...
May 2017: Transplantation Proceedings
https://www.readbyqxmd.com/read/28450174/atorvastatin-as-a-promising-anticryptococcal-agent
#19
Noelly de Queiroz Ribeiro, Marliete Carvalho Costa, Thaís Furtado Ferreira Magalhães, Hellem Cristina Silva Carneiro, Lorena Vívien Oliveira, Alide Caroline Lima Fontes, Julliana Ribeiro Alves Santos, Gabriela Freitas Ferreira, Glauber Ribeiro de Sousa Araujo, Vinícius Alves, Susana Frases, Tatiane Alves Paixão, Maria Aparecida de Resende Stoianoff, Daniel Assis Santos
Cryptococcosis caused by Cryptococcus gattii leads to pneumonia and meningoencephalitis, and has a high mortality rate worldwide due to the inadequacy of available therapy and increasing drug resistance. There is a need to develop effective treatments, and drug repositioning is an interesting alternative to achieve new strategies to treat cryptococcosis. Atorvastatin (ATO), a statin currently used to treat hypercholesterolaemia, was tested in this study as an adjuvant to control infections caused by C. gattii...
June 2017: International Journal of Antimicrobial Agents
https://www.readbyqxmd.com/read/28444032/thoughts-on-the-development-of-active-regional-public-health-systems
#20
Ademar Arthur Chioro Dos Reis, Ana Paula Menezes Sóter, Lumena Almeida Castro Furtado, Silvana Souza da Silva Pereira
Decentralization and regionalization are strategic themes for reforms in the health system. This paper analyzes the complex process of health regionalization being developed in Brazil. This paper identifies that the normative framework from the Brazilian National Health System, SUS has made advances with respect to its institutionalization and overcoming the initial centrality involved in municipalization. This has strengthened the development of regionalization and the intergovernmental agreement on health but the evidence points to the need to promote a revision...
April 2017: Ciência & Saúde Coletiva
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