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JOURNAL ARTICLE
Jessica L Sheehan, Ariel A Jordan, Kira L Newman, Laura A Johnson, Dala Eloubeidi, Shirley Cohen-Mekelburg, Jeffrey A Berinstein, Renuka Tipirneni, Peter D R Higgins
INTRODUCTION: Depression and anxiety are highly prevalent among individuals with inflammatory bowel disease (IBD); however, little is understood about how social determinants of health (SDOH) may impact mental health diagnoses in this population. The social vulnerability index (SVI) is a publicly available tool that can be used to study SDOH in IBD patients. METHODS: Home addresses from a retrospective cohort of IBD patients at a single center were used to geocode patients to their individual census tract and corresponding SVI...
October 25, 2023: Inflammatory Bowel Diseases
#22
JOURNAL ARTICLE
Joseph C Watso, Jens N Cuba, Savannah L Boutwell, Justine Moss, Allison K Bowerfind, Isabela M Fernandez, Jessica M Cassette, Allyson M May, Katherine F Kirk
INTRODUCTION: There is growing interest in how breathing pace, pattern, and training (e.g., device-guided or -resisted breathing) affect cardiovascular health. It is unknown whether the route of breathing (nasal versus oral) affects prognostic cardiovascular variables. Because nasal breathing can improve other physiological variables (e.g., airway dilation), we hypothesized that nasal compared with oral breathing would acutely lower blood pressure (BP) and improve heart rate variability (HRV) metrics...
October 23, 2023: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
#23
JOURNAL ARTICLE
Edmund Arthur, Swetha Ravichandran, Peter J Snyder, Jessica Alber, Jennifer Strenger, Ava K Bittner, Rima Khankan, Stephanie L Adams, Nicole M Putnam, Karin R Lypka, Juan A Piantino, Stuart Sinoff
BACKGROUND: Compared to standard neuro-diagnostic techniques, retinal biomarkers provide a probable low-cost and non-invasive alternative for early Alzheimer's disease (AD) risk screening. We have previously quantified the periarteriole and perivenule capillary free zones (mid-peripheral CFZs) in cognitively unimpaired (CU) young and older adults as novel metrics of retinal tissue oxygenation. There is a breakdown of the inner retinal blood barrier, pericyte loss, and capillary non-perfusion or dropout in AD leading to potential enlargement of the mid-peripheral CFZs...
October 12, 2023: Alzheimer's Research & Therapy
#24
JOURNAL ARTICLE
Jori L Waner, Hanna K Hausman, Jessica N Kraft, Cheshire Hardcastle, Nicole D Evangelista, Andrew O'Shea, Alejandro Albizu, Emanuel M Boutzoukas, Emily J Van Etten, Pradyumna K Bharadwaj, Hyun Song, Samantha G Smith, Steven T DeKosky, Georg A Hishaw, Samuel S Wu, Michael Marsiske, Ronald Cohen, Gene E Alexander, Eric C Porges, Adam J Woods
Limited research exists on the association between resting-state functional network connectivity in the brain and learning and memory processes in advanced age. This study examined within-network connectivity of cingulo-opercular (CON), frontoparietal control (FPCN), and default mode (DMN) networks, and verbal and visuospatial learning and memory in older adults. Across domains, we hypothesized that greater CON and FPCN connectivity would associate with better learning, and greater DMN connectivity would associate with better memory...
October 10, 2023: GeroScience
#25
JOURNAL ARTICLE
Vasiliki Rahimzadeh, Jennifer Fogarty, Timothy Caulfield, Serena Auñón-Chancellor, Pascal Borry, Jessica Candia, I Glenn Cohen, Marisa Covington, Holly Fernandez Lynch, Henry T Greely, Michelle Hanlon, James Hatt, Lucie Low, Jerry Menikoff, Eric M Meslin, Steven Platts, Vardit Ravitsky, Tara Ruttley, Rachael D Seidler, Jeremy Sugarman, Emmanuel Urquieta, Michael A Williams, Paul Root Wolpe, Dorit Donoviel, Amy L McGuire
Rules are needed for human research in commercial spaceflight.
September 29, 2023: Science
#26
REVIEW
Edward C Kuan, Eric W Wang, Nithin D Adappa, Daniel M Beswick, Nyall R London, Shirley Y Su, Marilene B Wang, Waleed M Abuzeid, Borislav Alexiev, Jeremiah A Alt, Paolo Antognoni, Michelle Alonso-Basanta, Pete S Batra, Mihir Bhayani, Diana Bell, Manuel Bernal-Sprekelsen, Christian S Betz, Jean-Yves Blay, Benjamin S Bleier, Juliana Bonilla-Velez, Claudio Callejas, Ricardo L Carrau, Roy R Casiano, Paolo Castelnuovo, Rakesh K Chandra, Vasileios Chatzinakis, Simon B Chen, Alexander G Chiu, Garret Choby, Naweed I Chowdhury, Martin J Citardi, Marc A Cohen, Roi Dagan, Gianluca Dalfino, Iacopo Dallan, Camila Soares Dassi, John de Almeida, Angelo P Dei Tos, John M DelGaudio, Charles S Ebert, Ivan H El-Sayed, Jean Anderson Eloy, James J Evans, Christina H Fang, Nyssa F Farrell, Marco Ferrari, Nancy Fischbein, Adam Folbe, Wytske J Fokkens, Meha G Fox, Valerie J Lund, Gary L Gallia, Paul A Gardner, Mathew Geltzeiler, Christos Georgalas, Anne E Getz, Satish Govindaraj, Stacey T Gray, Jessica W Grayson, Bradley A Gross, Jordon G Grube, Ruifeng Guo, Patrick K Ha, Ashleigh A Halderman, Ehab Y Hanna, Richard J Harvey, Stephen C Hernandez, Adam L Holtzman, Claire Hopkins, Zhigang Huang, Zhenxiao Huang, Ian M Humphreys, Peter H Hwang, Alfred M Iloreta, Masaru Ishii, Michael E Ivan, Aria Jafari, David W Kennedy, Mohemmed Khan, Adam J Kimple, Todd T Kingdom, Anna Knisely, Ying-Ju Kuo, Devyani Lal, Eric D Lamarre, Ming-Ying Lan, Hien Le, Matt Lechner, Nancy Y Lee, Jivianne K Lee, Victor H Lee, Corinna G Levine, Jin-Ching Lin, Derrick T Lin, Brian C Lobo, Tran Locke, Amber U Luong, Kelly R Magliocca, Svetomir N Markovic, Gesa Matnjani, Erin L McKean, Cem Meço, William M Mendenhall, Loren Michel, Shorook Na'ara, Piero Nicolai, Daniel W Nuss, Gurston G Nyquist, Gretchen M Oakley, Kazuhiro Omura, Richard R Orlandi, Nobuyoshi Otori, Peter Papagiannopoulos, Zara M Patel, David G Pfister, Jack Phan, Alkis J Psaltis, Mindy R Rabinowitz, Murugappan Ramanathan, Ryan Rimmer, Marc R Rosen, Olabisi Sanusi, Zoukaa B Sargi, Philippe Schafhausen, Rodney J Schlosser, Ahmad R Sedaghat, Brent A Senior, Raj Shrivastava, Raj Sindwani, Timothy L Smith, Kristine A Smith, Carl H Snyderman, C Arturo Solares, Satyan B Sreenath, Aldo Stamm, Katharina Stölzel, Baran Sumer, Pavol Surda, Bobby A Tajudeen, Lester D R Thompson, Brian D Thorp, Charles C L Tong, Raymond K Tsang, Justin H Turner, Mario Turri-Zanoni, Aaron M Udager, Thibaut van Zele, Kyle VanKoevering, Kevin C Welch, Sarah K Wise, Ian J Witterick, Tae-Bin Won, Stephanie N Wong, Bradford A Woodworth, Peter-John Wormald, William C Yao, Chien-Fu Yeh, Bing Zhou, James N Palmer
BACKGROUND: Sinonasal neoplasms, whether benign and malignant, pose a significant challenge to clinicians and represent a model area for multidisciplinary collaboration in order to optimize patient care. The International Consensus Statement on Allergy and Rhinology: Sinonasal Tumors (ICSNT) aims to summarize the best available evidence and presents 48 thematic and histopathology-based topics spanning the field. METHODS: In accordance with prior International Consensus Statement on Allergy and Rhinology documents, ICSNT assigned each topic as an Evidence-Based Review with Recommendations, Evidence-Based Review, and Literature Review based on the level of evidence...
February 2024: International Forum of Allergy & Rhinology
#27
JOURNAL ARTICLE
Zach Burningham, George L Jackson, Jessica L Kelleher, Isis Morris, Melissa B Stevens, Joy Cohen, Gerald Maloney, Brian C Sauer, Ahmad S Halwani, Wei Chen, Camille P Vaughan
BACKGROUND: The Enhancing Quality of Prescribing Practices for Older Veterans Discharged from the Emergency Department (EQUIPPED) program developed an audit and feedback health information technology (IT) solution with the intent to replace the in-person academic detailing service provided by the program. The EQUIPPED dashboard provides emergency department (ED) providers with a personalized view of their prescribing performance. OBJECTIVES: Here, we analyze the association between ED provider characteristics and viewership of the EQUIPPED dashboard, adding insight into strategies for addressing barriers to initial use...
August 2023: Applied Clinical Informatics
#28
JOURNAL ARTICLE
Isaac L Ahuvia, Mallory L Dobias, Katherine A Cohen, Brady D Nelson, Lauren L Richmond, Bonita London, Jessica L Schleider
Objective : The COVID-19 pandemic has simultaneously exacerbated mental health concerns among college students and made it more challenging for many students to access mental health support. However, little is known about the extent of mental health support loss among college students, or which students have lost support. Participants: 415 undergraduate students who reported receiving mental health support prior to the pandemic participated. Methods : Students completed an online questionnaire between March and May of 2020...
August 22, 2023: Journal of American College Health: J of ACH
#29
JOURNAL ARTICLE
Roger Peck, Helen L Storey, Becky Barney, Shirli Israeli, Olivia Halas, Deborah Oroszlan, Shiri Brodsky, Neha Agarwal, Eileen Murphy, Mariana Sagalovsky, Jessica Cohen, Elizabeth Trias, Aaron Schutzer, David S Boyle
Diagnostics are critical tools that guide clinical decision-making for patient care and support disease surveillance. Despite its importance, developers and manufacturers often note that access to specimen panels and essential reagents is one of the key challenges in developing quality diagnostics, particularly in low-resource settings. A recent example, as the COVID-19 pandemic unfolded there was a need for clinical samples across the globe to support the rapid development of diagnostics. To address these challenges and gaps, PATH, a global nonprofit, along with its partners collaborated to create a COVID-19 biorepository to improve access to biological samples...
2023: PLOS Glob Public Health
#30
JOURNAL ARTICLE
Jessica L Baylor, Matthew Rae, Shahid Manzar, Mark Pallis, Hans P Olsen, Anil Akoon, Louis C Grandizio
PURPOSE: Although the initial description of the distal biceps tendon (DBT) hook test (HT) reported 100% sensitivity (Sn) and specificity (Sp), subsequent retrospective series have demonstrated imperfect validity. The purpose of this investigation was to prospectively assess the validity and reliability of the HT for complete DBT ruptures. We aimed to determine the Sn/Sp and interrater reliability for the HT. METHODS: A consecutive series of adult patients presenting to our outpatient clinics with an elbow complaint was prospectively examined...
August 12, 2023: Journal of Hand Surgery
#31
JOURNAL ARTICLE
Kevin C Flanagan, Jon Earls, Ian Schillebeeckx, Jeffrey Hiken, Rachel L Wellinghoff, Natalie A LaFranzo, Zachary S Bradley, Joey Babbitt, William H Westra, Raymond Hsu, Lincoln Nadauld, Howard Mcleod, Sean D Firth, Brittany Sharp, Josh Fuller, Vera Vavinskaya, Leisa Sutton, Ida Deichaite, Samuel D Bailey, Vlad C Sandulache, Matthew J Rendo, Orlan K Macdonald, Karim Welaya, James L Wade, Andrew W Pippas, Jennifer Slim, Bruce Bank, Steven J Saccaro, Xingwei Sui, Adil Akhtar, Savitha Balaraman, Steven E Kossman, Scott A Sonnier, Todd D Shenkenberg, Warren L Alexander, Katherine A Price, Charles L Bane, Jessica Ley, David N Messina, Jarret I Glasscock, Ezra E W Cohen, Douglas R Adkins, Eric J Duncavage
PURPOSE: Anti-PD-1 therapy provides clinical benefit in 40-50% of patients with relapsed and/or metastatic head and neck squamous cell carcinoma (RM-HNSCC). Selection of anti- PD-1 therapy is typically based on patient PD-L1 immunohistochemistry (IHC) which has low specificity for predicting disease control. Therefore, there is a critical need for a clinical biomarker that will predict clinical benefit to anti-PD-1 treatment with high specificity. METHODS: Clinical treatment and outcomes data for 103 RM-HNSCC patients were paired with RNA-sequencing data from formalin-fixed patient samples...
August 8, 2023: Journal of Cancer Research and Clinical Oncology
#32
RANDOMIZED CONTROLLED TRIAL
Zoe K McQuilten, Le Thi Phuong Thao, Sant-Rayn Pasricha, Andrew S Artz, Michael Bailey, Andrew T Chan, Harvey Jay Cohen, Jessica E Lockery, Anne M Murray, Mark R Nelson, Hans G Schneider, Rory Wolfe, Robyn L Woods, Erica M Wood, John J McNeil
BACKGROUND: Daily low-dose aspirin increases major bleeding; however, few studies have investigated its effect on iron deficiency and anemia. OBJECTIVE: To investigate the effect of low-dose aspirin on incident anemia, hemoglobin, and serum ferritin concentrations. DESIGN: Post hoc analysis of the ASPREE (ASPirin in Reducing Events in the Elderly) randomized controlled trial. (ClinicalTrials.gov: NCT01038583). SETTING: Primary/community care in Australia and the United States...
July 2023: Annals of Internal Medicine
#33
JOURNAL ARTICLE
Sheila A M Rauch, Margaret R Venners, Carly Ragin, Gretchen Ruhe, Kristen E Lamp, Mark Burton, Andrew Pomerantz, Nancy Bernardy, Paula P Schnurr, Jessica L Hamblen, Kyle Possemato, Rebecca Sripada, Laura O Wray, Katherine Dollar, Michael Wade, Millie C Astin, Jeffrey A Cigrang
Prolonged exposure (PE) is a first-line treatment for posttraumatic stress disorder (PTSD) available in specialty mental health. PE for primary care (PE-PC) is a brief version of PE adapted for primary care mental health integration, composed of four-eight, 30-min sessions. Using retrospective data of PE-PC training cases from 155 Veterans Health Administration (VHA) providers in 99 VHA clinics who participated in a 4- to 6-month PE-PC training and consultation program, we examined patients' PTSD and depression severity across sessions via mixed effects multilevel linear modeling...
June 15, 2023: Psychological Services
#34
REVIEW
Brittany Lapin, Matthew L Cohen, Nadia Corsini, Alyssa Lanzi, Sarah C Smith, Antonia V Bennett, Nancy Mayo, Rebecca Mercieca-Bebber, Sandra A Mitchell, Claudia Rutherford, Jessica Roydhouse
AIMS: Many large-scale population-based surveys, research studies, and clinical care allow for inclusion of proxy reporting as a strategy to collect outcomes when patients are unavailable or unable to provide reliable self-report. Prior work identified an absence of methodological guidelines regarding proxy reporting in adult populations, including who can serve as a proxy, and considerations for data collection, analysis, and reporting. The primary objective of this work by the ISOQOL Proxy Task Force was to review documents and clinical outcome assessment measures with respect to proxy reporting and to develop, through consensus, considerations for proxy reporting...
June 2, 2023: Journal of Patient-Reported Outcomes
#35
JOURNAL ARTICLE
Abubaker Ibrahim Elbur, Musie Ghebremichael, Deborah Konkle-Parker, Deborah L Jones, Shelby Collins, Adaora A Adimora, Michael F Schneider, Mardge H Cohen, Bani Tamraz, Michael Plankey, Tracey Wilson, Adebola Adedimeji, Jessica E Haberer, Denise L Jacobson
BACKGROUND: Polypharmacy, using five or more medications, may increase the risk of nonadherence to prescribed treatment. We aimed to identify the interrelationship between trajectories of adherence to antiretroviral therapy (ART) and polypharmacy. METHODS: We included women with HIV (aged ≥ 18) enrolled in the Women's Interagency HIV Study in the United States from 2014 to 2019. We used group-based trajectory modeling (GBTM) to identify trajectories of adherence to ART and polypharmacy and the dual GBTM to identify the interrelationship between adherence and polypharmacy...
May 13, 2023: AIDS Research and Therapy
#36
JOURNAL ARTICLE
Christina C Hicks, Jessica A Gephart, J Zachary Koehn, Shinnosuke Nakayama, Hanna J Payne, Edward H Allison, Dyhia Belhbib, Ling Cao, Philippa J Cohen, Jessica Fanzo, Etienne Fluet-Chouinard, Stefan Gelcich, Christopher D Golden, Kelvin D Gorospe, Moenieba Isaacs, Caitlin D Kuempel, Kai N Lee, M Aaron MacNeil, Eva Maire, Jemimah Njuki, Nitya Rao, U Rashid Sumaila, Elizabeth R Selig, Shakuntala H Thilsted, Colette C C Wabnitz, Rosamond L Naylor
Injustices are prevalent in food systems, where the accumulation of vast wealth is possible for a few, yet one in ten people remain hungry. Here, for 194 countries we combine aquatic food production, distribution and consumption data with corresponding national policy documents and, drawing on theories of social justice, explore whether barriers to participation explain unequal distributions of benefits. Using Bayesian models, we find economic and political barriers are associated with lower wealth-based benefits; countries produce and consume less when wealth, formal education and voice and accountability are lacking...
October 2022: Nature food
#37
Maimuna S Paul, Sydney L Michener, Hongling Pan, Jessica M Pfliger, Jill A Rosenfeld, Vanesa C Lerma, Alyssa Tran, Megan A Longley, Richard A Lewis, Monika Weisz-Hubshman, Mir Reza Bekheirnia, Nasim Bekheirnia, Lauren Massingham, Michael Zech, Matias Wagner, Hartmut Engels, Kirsten Cremer, Elisabeth Mangold, Sophia Peters, Jessica Trautmann, Jessica L Mester, Maria J Guillen Sacoto, Richard Person, Pamela P McDonnell, Stacey R Cohen, Laina Lusk, Ana S A Cohen, Jean-Baptiste Le Pichon, Tomi Pastinen, Dihong Zhou, Kendra Engleman, Caroline Racine, Laurence Faivre, Sébastien Moutton, Anne-Sophie Denommé- Pichon, Sarah Schuhmann, Georgia Vasileiou, Sophie Russ-Hall, Ingrid E Scheffer, Gemma L Carvill, Heather Mefford, Undiagnosed Diseases Network, Carlos A Bacino, Brendan H Lee, Hsiao-Tuan Chao
PPFIA3 encodes the Protein-Tyrosine Phosphatase, Receptor-Type, F Polypeptide-Interacting Protein Alpha-3 (PPFIA3), which is a member of the LAR protein-tyrosine phosphatase-interacting protein (liprin) family involved in synaptic vesicle transport and presynaptic active zone assembly. The protein structure and function are well conserved in both invertebrates and vertebrates, but human diseases related to PPFIA3 dysfunction are not yet known. Here, we report 14 individuals with rare mono-allelic PPFIA3 variants presenting with features including developmental delay, intellectual disability, hypotonia, autism, and epilepsy...
March 29, 2023: medRxiv
#38
JOURNAL ARTICLE
Caroline Himbert, Jennifer Ose, Biljana Gigic, Richard Viskochil, Kelly Santuci, Tengda Lin, Anjelica Ashworth, Jessica N Cohan, Courtney L Scaife, Jolanta Jedrzkiewicz, Victoria Damerell, Katelyn M Atkins, Jun Gong, Matthew G Mutch, Corey Bernadt, Seth Felder, Julian Sanchez, Stacey A Cohen, Mukta K Krane, Nathan Hinkle, Elizabeth Wood, Anita R Peoples, Jane C Figueiredo, Adetunji T Toriola, Erin M Siegel, Christopher I Li, David Shibata, Kenneth Boucher, June L Round, Alexis B Ulrich, Martin Schneider, Lyen C Huang, Sheetal Hardikar, Cornelia M Ulrich
BACKGROUND: Physical activity and BMI have been individually associated with cancer survivorship but have not yet been studied in combinations in colorectal cancer patients. Here, we investigate individual and combined associations of physical activity and BMI groups with colorectal cancer survival outcomes. METHODS: Self-reported physical activity levels (MET hrs/wk) were assessed using an adapted version of the International Physical Activity Questionnaire (IPAQ) at baseline in 931 patients with stage I-III colorectal cancer and classified into 'highly active' and'not-highly active'(≥ / < 18 MET hrs/wk)...
April 3, 2023: BMC Cancer
#39
JOURNAL ARTICLE
Mark A Marzinke, Jessica M Fogel, Zhe Wang, Estelle Piwowar-Manning, Ryan Kofron, Amber Moser, Pradip Bhandari, Ryann Gollings, Lane R Bushman, Lei Weng, Elias K Halvas, John Mellors, Peter L Anderson, Deborah Persaud, Craig W Hendrix, Marybeth McCauley, Alex R Rinehart, Marty St Clair, Susan L Ford, James F Rooney, Adeola Adeyeye, Suwat Chariyalertsak, Kenneth Mayer, Roberto C Arduino, Myron S Cohen, Beatriz Grinsztejn, Brett Hanscom, Raphael J Landovitz, Susan H Eshleman
HPTN 083 demonstrated that injectable cabotegravir (CAB) was superior to oral tenofovir disoproxil fumarate-emtricitabine (TDF-FTC) for HIV prevention in cisgender men and transgender women who have sex with men. We previously analyzed 58 infections in the blinded phase of HPTN 083 (16 in the CAB arm and 42 in the TDF-FTC arm). This report describes 52 additional infections that occurred up to 1 year after study unblinding (18 in the CAB arm and 34 in the TDF-FTC arm). Retrospective testing included HIV testing, viral load testing, quantification of study drug concentrations, and drug resistance testing...
March 30, 2023: Antimicrobial Agents and Chemotherapy
#40
JOURNAL ARTICLE
Michael Reinke, Chloe Falke, Ken Cohen, David Anderson, Kathryn R Cullen, Jessica L Nielson
Emerging research suggests suicidality may have increased during the COVID-19 pandemic. This cross-sectional study aimed to advance understanding of suicide risk during the pandemic through novel use of a large insurance database. Using logistic regression across time-points, we estimated the effect of exposure to SARS-CoV-2 infection on rates of suicidal ideation and suicide attempts in infected individuals versus uninfected controls during the pandemic (March 2020 - September 2021). In uninfected individuals, we estimated the effect of exposure to the pandemic period versus the pre-pandemic control period (January 2017 to February 2020) on suicidality rates...
March 12, 2023: Psychiatry Research
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