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Jessica L Cohen

Jessica R Morgan, Marlysa Sullivan, Akihiko Masuda, Erin Tully, Lindsey L Cohen, Page L Anderson
Generalized anxiety disorder (GAD) is a prevalent psychiatric disorder associated with substantial impairment and poor treatment response. Yoga influences processes that are linked to the maintenance of GAD including mindfulness, anxiety, and heart rate variability, but has yet to be evaluated among people with the disorder. The present study is a first step toward documenting the efficacy of yoga for reducing worry among people with GAD using a single-subject AB design case series and daily ratings of worry...
January 2016: International Journal of Yoga Therapy
Nefyn H Williams, Jessica L Roberts, Nafees Ud Din, Nicola Totton, Joanna M Charles, Claire A Hawkes, Val Morrison, Zoe Hoare, Michelle Williams, Aaron W Pritchard, Swapna Alexander, Andrew Lemmey, Robert T Woods, Catherine Sackley, Pip Logan, Rhiannon T Edwards, Clare Wilkinson
OBJECTIVE: To conduct a rigorous feasibility study for a future definitive parallel-group randomised controlled trial (RCT) and economic evaluation of an enhanced rehabilitation package for hip fracture. SETTING: Recruitment from 3 acute hospitals in North Wales. Intervention delivery in the community. PARTICIPANTS: Older adults (aged ≥65) who received surgical treatment for hip fracture, lived independently prior to fracture, had mental capacity (assessed by clinical team) and received rehabilitation in the North Wales area...
October 5, 2016: BMJ Open
Stephen R Adams, Howard C Yang, Elamprakash N Savariar, Joe Aguilera, Jessica L Crisp, Karra A Jones, Michael A Whitney, Scott M Lippman, Ezra E W Cohen, Roger Y Tsien, Sunil J Advani
Tumour resistance to radiotherapy remains a barrier to improving cancer patient outcomes. To overcome radioresistance, certain drugs have been found to sensitize cells to ionizing radiation (IR). In theory, more potent radiosensitizing drugs should increase tumour kill and improve patient outcomes. In practice, clinical utility of potent radiosensitizing drugs is curtailed by off-target side effects. Here we report potent anti-tubulin drugs conjugated to anti-ErbB antibodies selectively radiosensitize to tumours based on surface receptor expression...
October 4, 2016: Nature Communications
Shannon M O'Connor, Christopher R Beam, Xiaochen Luo, L Adelyn Cohen, Jessica L VanHuysse, Robert E Emery, Eric Turkheimer, Pamela K Keel, S Alexandra Burt, Michael Neale, Steven Boker, Kelly Klump
OBJECTIVE: Prior twin studies provide support for a single "common factor" that contributes genetic and environmental risk to a range of disordered eating symptoms. However, the common factor may be indexed less well by binge eating (BE) than other symptoms of eating disorders [i.e., body dissatisfaction (BD) and weight preoccupation (WP)]. We sought to explore the presence of a common factor and test whether loadings differed across three key symptoms (i.e., BE, BD, WP). METHOD: Disordered eating was assessed via self-report in 631 female twin pairs from the Michigan State University Twin Registry...
September 16, 2016: International Journal of Eating Disorders
Jessica A Liu, Randi J Hagerman, Robert M Miller, Lisa T Craft, Brenda Finucane, Nicole Tartaglia, Elizabeth M Berry-Kravis, Stephanie L Sherman, Sharon A Kidd, Jeffrey Cohen
The objectives of the study were to assess the attitudes and experiences of clinicians involved in a consortium of clinics serving people with fragile X-associated disorders to gauge satisfaction with the consortium and its efforts to improve quality of life for patients and the community. An internet survey was sent to 26 fragile X (FX) clinic directors participating in the Fragile X Clinical and Research Consortium (FXCRC). Respondents were asked to complete 19 questions on consortium performance and outcomes relevant for their own clinic...
September 8, 2016: American Journal of Medical Genetics. Part A
Laura L Reimers, Supriya D Mehta, L Stewart Massad, Robert D Burk, Xianhong Xie, Jacques Ravel, Mardge H Cohen, Joel M Palefsky, Kathleen M Weber, Xiaonan Xue, Kathryn Anastos, Howard Minkoff, Jessica Atrio, Gypsyamber D'Souza, Qian Ye, Christine Colie, Christine P Zolnik, Gregory T Spear, Howard D Strickler
BACKGROUND:  Bacterial vaginosis (BV) is characterized by low abundance of Lactobacillus species, high pH, and immune cell infiltration and has been associated with an increased risk of human papillomavirus (HPV) infection. We molecularly assessed the cervicovaginal microbiota over time in human immunodeficiency virus (HIV)-infected and HIV-uninfected women to more comprehensively study the HPV-microbiota relationship, controlling for immune status. METHODS:  16S ribosomal RNA gene amplicon pyrosequencing and HPV DNA testing were conducted annually in serial cervicovaginal lavage specimens obtained over 8-10 years from African American women from Chicago, of whom 22 were HIV uninfected, 22 were HIV infected with a stable CD4(+) T-cell count of > 500 cells/mm(3), and 20 were HIV infected with progressive immunosuppression...
November 1, 2016: Journal of Infectious Diseases
Joshua D Hall, Jessica R Harrell, Kimberley W Cohen, Virginia L Miller, Patricia V Phelps, Jeanette G Cook
Certain racial and ethnic groups, individuals with disabilities, and those from low socioeconomic backgrounds remain underrepresented (UR) in the biomedical sciences. This underrepresentation becomes more extreme at each higher education stage. To support UR scholars during the critical transition from baccalaureate to PhD, we established an intensive, 1-yr postbaccalaureate training program. We hypothesized that this intervention would strengthen each participant's competitiveness for leading PhD programs and build a foundation of skills and self-efficacy important for success during and after graduate school...
2016: CBE Life Sciences Education
Jessica L Fry, Leona Al Sayah, Robert M Weisbrod, Isabelle Van Roy, Xiang Weng, Richard A Cohen, Markus M Bachschmid, Francesca Seta
Arterial stiffness, a major cardiovascular risk factor, develops within 2 months in mice fed a high-fat, high-sucrose (HFHS) diet, serving as a model of human metabolic syndrome, and it is associated with activation of proinflammatory and oxidant pathways in vascular smooth muscle (VSM) cells. Sirtuin-1 (SirT1) is an NAD(+)-dependent deacetylase regulated by the cellular metabolic status. Our goal was to study the effects of VSM SirT1 on arterial stiffness in the context of diet-induced metabolic syndrome. Overnight fasting acutely decreased arterial stiffness, measured in vivo by pulse wave velocity, in mice fed HFHS for 2 or 8 months, but not in mice lacking SirT1 in VSM (SMKO)...
September 2016: Hypertension
Jessica R Morgan, Marlysa Sullivan, Akihiko Masuda, Erin Tully, Lindsey L Cohen, Page L Anderson
Generalized anxiety disorder (GAD) is a prevalent psychiatric disorder associated with substantial impairment and poor treatment response. Yoga influences processes that are linked to the maintenance of GAD including mindfulness, anxiety, and heart rate variability, but has yet to be evaluated among people with the disorder. The present study is a first step toward documenting the efficacy of yoga for reducing worry among people with GAD using a single-subject AB design case series and daily ratings of worry...
July 14, 2016: International Journal of Yoga Therapy
Wesley T Kerr, Emily A Janio, Justine M Le, Jessica M Hori, Akash B Patel, Norma L Gallardo, Janar Bauirjan, Andrea M Chau, Shannon R D'Ambrosio, Andrew Y Cho, Jerome Engel, Mark S Cohen, John M Stern
PURPOSE: The average delay from first seizure to diagnosis of psychogenic non-epileptic seizures (PNES) is over 7 years. The reason for this delay is not well understood. We hypothesized that a perceived decrease in seizure frequency after starting an anti-seizure medication (ASM) may contribute to longer delays, but the frequency of such a response has not been well established. METHODS: Time from onset to diagnosis, medication history and associated seizure frequency was acquired from the medical records of 297 consecutive patients with PNES diagnosed using video-electroencephalographic monitoring...
August 2016: Seizure: the Journal of the British Epilepsy Association
Jessica L Ross, Luis F Queme, Elysia R Cohen, Kathryn J Green, Peilin Lu, Aaron T Shank, Suzie An, Renita C Hudgins, Michael P Jankowski
UNLABELLED: Musculoskeletal pain is a significantly common clinical complaint. Although it is known that muscles are quite sensitive to alterations in blood flow/oxygenation and a number of muscle pain disorders are based in problems of peripheral perfusion, the mechanisms by which ischemic-like conditions generate myalgia remain unclear. We found, using a multidisciplinary experimental approach, that ischemia and reperfusion injury (I/R) in male Swiss Webster mice altered ongoing and evoked pain-related behaviors in addition to activity levels through enhanced muscle interleukin-1 beta (IL1β)/IL1 receptor signaling to group III/IV muscle afferents...
June 29, 2016: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
Stacy L Davlin, Lenee Blanton, Krista Kniss, Desiree Mustaquim, Sophie Smith, Natalie Kramer, Jessica Cohen, Charisse Nitura Cummings, Shikha Garg, Brendan Flannery, Alicia M Fry, Lisa A Grohskopf, Joseph Bresee, Teresa Wallis, Wendy Sessions, Rebecca Garten, Xiyan Xu, Anwar Isa Abd Elal, Larisa Gubareva, John Barnes, David E Wentworth, Erin Burns, Jacqueline Katz, Daniel Jernigan, Lynnette Brammer
During the 2015-16 influenza season (October 4, 2015-May 21, 2016) in the United States, influenza activity* was lower and peaked later compared with the previous three seasons (2012-13, 2013-14, and 2014-15). Activity remained low from October 2015 until late December 2015 and peaked in mid-March 2016. During the most recent 18 influenza seasons (including this season), only two other seasons have peaked in March (2011-12 and 2005-06). Overall influenza activity was moderate this season, with a lower percentage of outpatient visits for influenza-like illness (ILI),(†) lower hospitalization rates, and a lower percentage of deaths attributed to pneumonia and influenza (P&I) compared with the preceding three seasons...
2016: MMWR. Morbidity and Mortality Weekly Report
Jason A Cohen, Joe Verghese, Jessica L Zwerling
Cognitive difficulties and gait abnormalities both increase with age. We review normal and pathologic changes in both gait and cognition in older adults. Gait performance in older individuals is linked to specific cognitive changes, in particular in executive function. Structural and functional assays highlight the shared anatomic control of cognitive and gait function, mostly in the prefrontal cortices. Cognitive impairment can be used to predict incident gait difficulties. Changes in gait, especially decreased gait velocity, may be a harbinger of impending cognitive decline...
November 2016: Maturitas
Emily R Oby, Sagi Perel, Patrick T Sadtler, Douglas A Ruff, Jessica L Mischel, David F Montez, Marlene R Cohen, Aaron P Batista, Steven M Chase
OBJECTIVE: A traditional goal of neural recording with extracellular electrodes is to isolate action potential waveforms of an individual neuron. Recently, in brain-computer interfaces (BCIs), it has been recognized that threshold crossing events of the voltage waveform also convey rich information. To date, the threshold for detecting threshold crossings has been selected to preserve single-neuron isolation. However, the optimal threshold for single-neuron identification is not necessarily the optimal threshold for information extraction...
June 2016: Journal of Neural Engineering
Jessica M Johnston, Yale E Cohen, Harry Shirley, Joji Tsunada, Sharath Bennur, Kate Christison-Lagay, Christin L Veeder
The advent of cranial implants revolutionized primate neurophysiological research because they allow researchers to stably record neural activity from monkeys during active behavior. Cranial implants have improved over the years since their introduction, but chronic implants still increase the risk for medical complications including bacterial contamination and resultant infection, chronic inflammation, bone and tissue loss and complications related to the use of dental acrylic. These complications can lead to implant failure and early termination of study protocols...
May 2016: Lab Animal
Jessica L Zwerling, Jason A Cohen, Joe Verghese
No abstract text is available yet for this article.
April 2016: Neurodegenerative Disease Management
David L Cohen, Christine Roffe, Jessica Beavan, Brenda Blackett, Carol A Fairfield, Shaheen Hamdy, Di Havard, Mary McFarlane, Carolee McLauglin, Mark Randall, Katie Robson, Polly Scutt, Craig Smith, David Smithard, Nikola Sprigg, Anushka Warusevitane, Caroline Watkins, Lisa Woodhouse, Philip M Bath
Post-stroke dysphagia (a difficulty in swallowing after a stroke) is a common and expensive complication of acute stroke and is associated with increased mortality, morbidity, and institutionalization due in part to aspiration, pneumonia, and malnutrition. Although most patients recover swallowing spontaneously, a significant minority still have dysphagia at six months. Although multiple advances have been made in the hyperacute treatment of stroke and secondary prevention, the management of dysphagia post-stroke remains a neglected area of research, and its optimal management, including diagnosis, investigation and treatment, have still to be defined...
June 2016: International Journal of Stroke: Official Journal of the International Stroke Society
L Alison Phillips, Joshua Cohen, Edith Burns, Jessica Abrams, Steffi Renninger
Non-adherence to health behaviors required for chronic illness self-management is pervasive. Advancing health-behavior theory to include behavioral initiation and maintenance factors, including reflective (e.g., belief- and feedback-based) and automatic (e.g., habit-based) mechanisms of adherence to different treatment-related behaviors could improve non-adherence prediction and intervention efforts. To test behavioral initiation and maintenance factors from an extended common sense self-regulation theoretical framework for predicting medication adherence and physical activity among patients with Type 2 diabetes...
March 16, 2016: Journal of Behavioral Medicine
Jason W Bennett, Anjali Yadava, Donna Tosh, Jetsumon Sattabongkot, Jack Komisar, Lisa A Ware, William F McCarthy, Jessica J Cowden, Jason Regules, Michele D Spring, Kristopher Paolino, Joshua D Hartzell, James F Cummings, Thomas L Richie, Joanne Lumsden, Edwin Kamau, Jittawadee Murphy, Cynthia Lee, Falgunee Parekh, Ashley Birkett, Joe Cohen, W Ripley Ballou, Mark E Polhemus, Yannick F Vanloubbeeck, Johan Vekemans, Christian F Ockenhouse
BACKGROUND: A vaccine to prevent infection and disease caused by Plasmodium vivax is needed both to reduce the morbidity caused by this parasite and as a key component in efforts to eradicate malaria worldwide. Vivax malaria protein 1 (VMP001), a novel chimeric protein that incorporates the amino- and carboxy- terminal regions of the circumsporozoite protein (CSP) and a truncated repeat region that contains repeat sequences from both the VK210 (type 1) and the VK247 (type 2) parasites, was developed as a vaccine candidate for global use...
February 2016: PLoS Neglected Tropical Diseases
Elizabeth L Baxter, Laura Aguila, Roberto Alonso-Mori, Christopher O Barnes, Christopher A Bonagura, Winnie Brehmer, Axel T Brunger, Guillermo Calero, Tom T Caradoc-Davies, Ruchira Chatterjee, William F Degrado, James S Fraser, Mohamed Ibrahim, Jan Kern, Brian K Kobilka, Andrew C Kruse, Karl M Larsson, Heinrik T Lemke, Artem Y Lyubimov, Aashish Manglik, Scott E McPhillips, Erik Norgren, Siew S Pang, S M Soltis, Jinhu Song, Jessica Thomaston, Yingssu Tsai, William I Weis, Rahel A Woldeyes, Vittal Yachandra, Junko Yano, Athina Zouni, Aina E Cohen
Higher throughput methods to mount and collect data from multiple small and radiation-sensitive crystals are important to support challenging structural investigations using microfocus synchrotron beamlines. Furthermore, efficient sample-delivery methods are essential to carry out productive femtosecond crystallography experiments at X-ray free-electron laser (XFEL) sources such as the Linac Coherent Light Source (LCLS). To address these needs, a high-density sample grid useful as a scaffold for both crystal growth and diffraction data collection has been developed and utilized for efficient goniometer-based sample delivery at synchrotron and XFEL sources...
January 2016: Acta Crystallographica. Section D, Structural Biology
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