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https://www.readbyqxmd.com/read/28102177/erratum-an-action-potential-driven-model-of-soleus-muscle-activation-dynamics-for-locomotor-like-movements-2015-j-neural-eng-12-046025
#1
Hojeong Kim, Thomas Sandercock, C Heckman
We published our study on modelling ans simulation of force production in cat soleus muscles during locomotor-like movements. Unfortunately, we recently found several typographical errors in equation (15), table 1 and figure 3E in the published paper. Those errors arose from mistakes on our part during transitioning of our manuscript from the paper to electronic version. We have confirmed that correction of our errors does not influence any simulation results and conclusions published in our paper. However, we think that the errors and their corrections should be noticed publically to prevent the readers from having difficulties in implementing our muscle model...
January 19, 2017: Journal of Neural Engineering
https://www.readbyqxmd.com/read/28095192/spike-centered-jitter-can-mistake-temporal-structure
#2
Jonathan Platkiewicz, Eran Stark, Asohan Amarasingham
Jitter-type spike resampling methods are routinely applied in neurophysiology for detecting temporal structure in spike trains (point processes). Several variations have been proposed. The concern has been raised, based on numerical experiments involving Poisson spike processes, that such procedures can be conservative. We study the issue and find it can be resolved by reemphasizing the distinction between spike-centered (basic) jitter and interval jitter. Focusing on spiking processes with no temporal structure, interval jitter generates an exact hypothesis test, guaranteeing valid conclusions...
January 17, 2017: Neural Computation
https://www.readbyqxmd.com/read/28076342/knowledge-beliefs-and-attitudes-report-on-patient-care-and-safety-in-undergraduate-students-validating-the-modified-apsq-iii-questionnaire
#3
Ezequiel García Elorrio, Dolores Macchiavello, Viviana Rodriguez, Yael Catalano, Giuliana Corna, Josefina Dahinten, Marina Ontivero
INTRODUCTION: Patient safety aims to achieve healthcare free of damage. The World Health Organization indicates that this objective is achieved through communication, analysis, and prevention of adverse events in patients. Organizational culture has been identified as one of the main factors for interventions aimed to reduce medical errors; and an essential component of safety culture is the attitude of health professionals towards medical error. Attitudes can be improved through appropriate education in biomedical careers but its inclusion in Argentina is scarce...
December 20, 2016: Medwave
https://www.readbyqxmd.com/read/28075713/an-activist-approach-to-sport-meets-youth-from-socially-vulnerable-backgrounds-possible-learning-aspirations
#4
Carla Luguetti, Kimberly L Oliver, Luiz Eduardo Pinto Basto Tourinho Dantas, David Kirk
PURPOSE: This study was a 2-phase activist research project aimed at co-creating a prototype pedagogical model for working with youth from socially vulnerable backgrounds in a sport context. This article addresses the learning aspirations (learning outcomes) that emerged when we created spaces for youth to develop strategies to manage the risks they face in their community. METHOD: This study took place in a socially and economically disadvantaged neighborhood in a Brazilian city where we worked with a group of 17 boys aged 13 to 15 years old, 4 coaches, a pedagogic coordinator, and a social worker...
January 11, 2017: Research Quarterly for Exercise and Sport
https://www.readbyqxmd.com/read/28075186/performance-on-tasks-of-visuospatial-memory-and-ability-a-cross-sectional-study-in-330-adolescents-aged-11-to-20
#5
Rudolf Burggraaf, Maarten A Frens, Ignace T C Hooge, Jos N van der Geest
Cognitive functions mature at different points in time between birth and adulthood. Of these functions, visuospatial skills, such as spatial memory and part-to-whole organization, have often been tested in children and adults but have been less frequently evaluated during adolescence. We studied visuospatial memory and ability during this critical developmental period, as well as the correlation between these abilities, in a large group of 330 participants (aged 11 to 20 years, 55% male). To assess visuospatial memory, the participants were asked to memorize and reproduce sequences of random locations within a grid using a computer...
January 11, 2017: Applied Neuropsychology. Child
https://www.readbyqxmd.com/read/28074581/conflating-capacity-authority-why-we-re-asking-the-wrong-question-in-the-adolescent-decision-making-debate
#6
Erica K Salter
Whether adolescents should be allowed to make their own medical decisions has been a topic of discussion in bioethics for at least two decades now. Are adolescents sufficiently capacitated to make their own medical decisions? Is the mature-minor doctrine, an uncommon legal exception to the rule of parental decision-making authority, something we should expand or eliminate? Bioethicists have dealt with the curious liminality of adolescents-their being neither children nor adults-in a variety of ways. However, recently there has been a trend to rely heavily, and often exclusively, on emerging neuroscientific and psychological data to answer these questions...
January 2017: Hastings Center Report
https://www.readbyqxmd.com/read/28068502/-our-time-is-up-a-relational-perspective-on-the-ending-of-a-single-psychotherapy-session
#7
Jerome S Gans
This paper, written from a relational perspective, examines the final minutes of an individual psychotherapy session, and is organized around the topics of boundary negotiation, unwitting self-disclosures, visual challenges, and countertransference. Attending to session-ending material is important because the separation involved lends heightened emotional intensity to the oftensignificant material that appears in the final minutes. This material often serves as a bridge to the psychotherapeutic work to be taken up in subsequent sessions...
December 31, 2016: American Journal of Psychotherapy
https://www.readbyqxmd.com/read/28064161/statistical-significance-versus-clinical-relevance
#8
REVIEW
Marieke H C van Rijn, Anneke Bech, Jean Bouyer, Jan A J G van den Brand
In March this year, the American Statistical Association (ASA) posted a statement on the correct use of P-values, in response to a growing concern that the P-value is commonly misused and misinterpreted. We aim to translate these warnings given by the ASA into a language more easily understood by clinicians and researchers without a deep background in statistics. Moreover, we intend to illustrate the limitations of P-values, even when used and interpreted correctly, and bring more attention to the clinical relevance of study findings using two recently reported studies as examples...
January 7, 2017: Nephrology, Dialysis, Transplantation
https://www.readbyqxmd.com/read/28063139/morphological-histological-and-immunohistochemical-study-of-the-area-postrema-in-the-dog
#9
Maria Oliveira, Francisco Fernández, Jordi Solé, Martí Pumarola
Circumventricular organs are specialized brain structures that are located mainly at the midsagittal line, around the third and fourth ventricles, often protruding into the lumen. They are positioned at the interface between the neuroparenchyma and the ventricular system of the brain. These highly vascularized nervous tissue structures differ from the brain parenchyma, as they lack a blood-brain barrier. Circumventricular organs have specialized sensory and secretory functions. It is essential for any pathologist who evaluates brain sections to have a solid knowledge of microscopic neuroanatomy and to recognize these numerous specialized structures within the nervous system as normal and not mistake them for pathological changes...
January 6, 2017: Anatomical Science International
https://www.readbyqxmd.com/read/28061042/assessing-the-expected-value-of-research-studies-in-reducing-uncertainty-and-improving-implementation-dynamics
#10
Sabine E Grimm, Simon Dixon, John W Stevens
BACKGROUND: With low implementation of cost-effective health technologies being a problem in many health systems, it is worth considering the potential effects of research on implementation at the time of health technology assessment. Meaningful and realistic implementation estimates must be of dynamic nature. OBJECTIVE: To extend existing methods for assessing the value of research studies in terms of both reduction of uncertainty and improvement in implementation by considering diffusion based on expert beliefs with and without further research conditional on the strength of evidence...
January 1, 2017: Medical Decision Making: An International Journal of the Society for Medical Decision Making
https://www.readbyqxmd.com/read/28060981/-communication-of-medical-errors-to-patients-questions-and-tools
#11
María Luz Bascuñán, Ana María Arriagada
For several years and in many different ways, medical errors have been studied. As expected, the majority of efforts have been directed to prevent clinical errors during the different phases of health care. Nevertheless, less attention has been given to what happens when a negative effect has already occurred. The present work describes the doubts and difficulties that doctors deal with when facing an error and to describe the communicational tools that the literature offers to cope with them. The definition of medical error was the starting point that was used to later analyze the evidence about what, why and how to inform medical errors from an ethical and technical point of view...
September 2016: Revista Médica de Chile
https://www.readbyqxmd.com/read/28060945/examining-sources-of-error-in-pcr-by-single-molecule-sequencing
#12
Vladimir Potapov, Jennifer L Ong
Next-generation sequencing technology has enabled the detection of rare genetic or somatic mutations and contributed to our understanding of disease progression and evolution. However, many next-generation sequencing technologies first rely on DNA amplification, via the Polymerase Chain Reaction (PCR), as part of sample preparation workflows. Mistakes made during PCR appear in sequencing data and contribute to false mutations that can ultimately confound genetic analysis. In this report, a single-molecule sequencing assay was used to comprehensively catalog the different types of errors introduced during PCR, including polymerase misincorporation, structure-induced template-switching, PCR-mediated recombination and DNA damage...
2017: PloS One
https://www.readbyqxmd.com/read/28057945/ismp-medication-error-report-analysis-aggrastat-argatroban-mix-ups-don-t-expect-radiofrequency-identification-stock-systems-to-be-perfect-paralyzed-by-mistakes-reassess-the-safety-of-neuromuscular-blockers-in-your-facility
#13
Michael R Cohen, Judy L Smetzer
These medication errors have occurred in health care facilities at least once. They will happen again-perhaps where you work. Through education and alertness of personnel and procedural safeguards, they can be avoided. You should consider publishing accounts of errors in your newsletters and/or presenting them at your inservice training programs. Your assistance is required to continue this feature. The reports described here were received through the Institute for Safe Medication Practices (ISMP) Medication Errors Reporting Program...
December 2016: Hospital Pharmacy
https://www.readbyqxmd.com/read/28048665/su-f-t-243-major-risks-in-radiotherapy-a-review-based-on-risk-analysis-literature
#14
J López-Tarjuelo, A Bouché-Babiloni, V Morillo-Macías, M Guasp-Tortajada, N Iglesias-Montenegro, P Monasor-Denia, C Ferrer-Albiach
PURPOSE: We present a literature review of risk analyses in radiotherapy to highlight the most reported risks and facilitate the spread of this valuable information so that professionals can be aware of these major threats before performing their own studies. METHODS: We considered studies with at least an estimation of the probability of occurrence of an adverse event (O) and its associated severity (S). They cover external beam radiotherapy, brachytherapy, intraoperative radiotherapy, and stereotactic techniques...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28047831/we-f-brc-00-keynote-address-learning-from-medical-errors-a-partnership-for-progress
#15
Michael Herman, Jean Moran
: Leilani Schweitzer understands medical error as few others do: through the death of her child. Faced with this profound loss, she has made a choice. Instead of pursing action through the courts she works with healthcare community to understand why mistakes happen and what can be done to respond to them in a meaningful way. In this keynote address for the TG100 Certificate Course on Risk Analysis, she will share her story and the lessons that have emerged. She will highlight the importance of investigating and understanding errors, as well as the role of leadership in accomplishing this...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28047175/we-f-brc-01-keynote-address-learning-from-medical-errors-a-partnership-for-progress
#16
L Schweitzer
: Leilani Schweitzer understands medical error as few others do: through the death of her child. Faced with this profound loss, she has made a choice. Instead of pursing action through the courts she works with healthcare community to understand why mistakes happen and what can be done to respond to them in a meaningful way. In this keynote address for the TG100 Certificate Course on Risk Analysis, she will share her story and the lessons that have emerged. She will highlight the importance of investigating and understanding errors, as well as the role of leadership in accomplishing this...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28042121/conversion-of-a-unicompartmental-knee-arthroplasty-to-a-total-knee-arthroplasty-can-we-achieve-a-primary-result
#17
E Thienpont
OBJECTIVES: Unicompartmental knee arthroplasty (UKA) is a potential treatment for isolated bone on bone osteoarthritis when limited to a single compartment. The risk for revision of UKA is three times higher than for total knee arthroplasty (TKA). The aim of this review was to discuss the different revision options after UKA failure. MATERIALS AND METHODS: A search was performed for English language articles published between 2006 and 2016. After reviewing titles and abstracts, 105 papers were selected for further analysis...
January 2017: Bone & Joint Journal
https://www.readbyqxmd.com/read/28040741/premature-silencing-of-the-spindle-assembly-checkpoint-is-prevented-by-the-bub1-h2a-sgo1-pp2a-axis-in-saccharomyces-cerevisiae
#18
Fengzhi Jin, Michael Bokros, Yanchang Wang
The spindle assembly checkpoint (SAC) monitors mistakes in kinetochore-microtubule interaction and its activation prevents anaphase entry. The SAC remains active until all chromosomes have achieved bipolar attachment that applies tension on kinetochores. Our previous data in budding yeast Saccharomyces cerevisiae show that Ipl1/Aurora B kinase and a centromere-associated protein Sgo1 are required to prevent SAC silencing prior to tension generation, but we believe that this regulatory network is incomplete...
December 30, 2016: Genetics
https://www.readbyqxmd.com/read/28040687/de-identification-of-patient-notes-with-recurrent-neural-networks
#19
Franck Dernoncourt, Ji Young Lee, Ozlem Uzuner, Peter Szolovits
OBJECTIVE: Patient notes in electronic health records (EHRs) may contain critical information for medical investigations. However, the vast majority of medical investigators can only access de-identified notes, in order to protect the confidentiality of patients. In the United States, the Health Insurance Portability and Accountability Act (HIPAA) defines 18 types of protected health information that needs to be removed to de-identify patient notes. Manual de-identification is impractical given the size of electronic health record databases, the limited number of researchers with access to non-de-identified notes, and the frequent mistakes of human annotators...
December 30, 2016: Journal of the American Medical Informatics Association: JAMIA
https://www.readbyqxmd.com/read/28038759/-medication-errors-in-anesthesia-unacceptable-or-unavoidable
#20
Ira Dhawan, Anurag Tewari, Sankalp Sehgal, Ashish Chandra Sinha
Medication errors are the common causes of patient morbidity and mortality. It adds financial burden to the institution as well. Though the impact varies from no harm to serious adverse effects including death, it needs attention on priority basis since medication errors' are preventable. In today's world where people are aware and medical claims are on the hike, it is of utmost priority that we curb this issue. Individual effort to decrease medication error alone might not be successful until a change in the existing protocols and system is incorporated...
December 27, 2016: Revista Brasileira de Anestesiologia
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