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Periventricular hemorrhage

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https://www.readbyqxmd.com/read/29764568/-effect-of-early-application-of-recombinant-human-erythropoietin-on-white-matter-development-in-preterm-infants
#1
Shu-Shuo Yang, Fa-Lin Xu, Hui-Qing Cheng, Hao-Ran Xu, Lin Yang, Jing-Yue Xing, Lin Cheng
OBJECTIVE: To evaluate the effect of early application of recombinant human erythropoietin (rhEPO) on white matter development in preterm infants using fractional anisotropy (FA) of magnetic resonance diffusion tensor imaging (DTI). METHODS: A total of 81 preterm infants with gestational age &le;32 weeks, birth weight <1 500 g, and hospitalization within 24 hours after birth were randomly divided into rhEPO group (42 infants) and control group (39 infants)...
May 2018: Zhongguo Dang Dai Er Ke za Zhi, Chinese Journal of Contemporary Pediatrics
https://www.readbyqxmd.com/read/29746715/quantitative-susceptibility-map-analysis-in-preterm-neonates-with-germinal-matrix-intraventricular-hemorrhage
#2
Domenico Tortora, Mariasavina Severino, Jan Sedlacik, Benedetta Toselli, Mariya Malova, Alessandro Parodi, Giovanni Morana, Marco Massimo Fato, Luca Antonio Ramenghi, Andrea Rossi
BACKGROUND: Germinal matrix-intraventricular hemorrhage (GMH-IVH) is a common form of intracranial hemorrhage occurring in preterm neonates that may affect normal brain development. Although the primary lesion is easily identified on MRI by the presence of blood products, its exact extent may not be recognizable with conventional sequences. Quantitative susceptibility mapping (QSM) quantify the spatial distribution of magnetic susceptibility within biological tissues, including blood degradation products...
May 10, 2018: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/29726792/early-surgical-management-and-long-term-surgical-outcome-for-intraventricular-hemorrhage-related-posthemorrhagic-hydrocephalus-in-shunt-treated-premature-infants
#3
Hans Christoph Bock, Jacqueline Feldmann, Hans Christoph Ludwig
OBJECTIVE Perinatal intraventricular hemorrhage (IVH) in premature neonates may lead to severe neurological disability and lifelong treatment requirement for consecutive posthemorrhagic hydrocephalus (PHHC). Early CSF diversion as a temporizing measure, or a permanent ventriculoperitoneal shunt (VPS), is the treatment of choice. Preterm neonates are not only at high risk for different perinatal but also for treatment-related complications. The authors reviewed their institutional neurosurgical management for preterm neonates with IVH-related PHHC and evaluated shunt-related surgical outcome for this particular hydrocephalus etiology after completion of a defined follow-up period of 5 years after initial shunt insertion...
May 4, 2018: Journal of Neurosurgery. Pediatrics
https://www.readbyqxmd.com/read/29688161/brain-injured-survivors-of-monochorionic-twin-pregnancies-complicated-by-single-intrauterine-death-mr-findings-in-a-multicenter-study
#4
Giorgio Conte, Andrea Righini, Paul D Griffiths, Mariangela Rustico, Mariano Lanna, Fiona L Mackie, Lorenzo Pinelli, Federico Prefumo, Nicola Persico, Mark S Igra, Cecilia Parazzini, Chiara Doneda, Anna Fichera, Claudia Ambrosi, Mark Kilby, Mariasavina Severino, Fabio Triulzi, Andrea Rossi, Nicholas Skipper
Purpose To describe and classify the range of brain injuries present at prenatal, in-utero magnetic resonance (MR) imaging in co-twin survivors of monochorionic (MC) twin pregnancies complicated by single intrauterine death (SIUD). Materials and Methods This retrospective, observational study from six tertiary fetal medicine centers that perform tertiary-level prenatal in-utero MR studies reviewed cases in which prenatal in-utero MR imaging had shown a brain injury in a surviving co-twin of a twin pregnancy with a MC component complicated by SIUD...
April 24, 2018: Radiology
https://www.readbyqxmd.com/read/29664051/predictive-value-of-cranial-ultrasound-for-neurodevelopmental-outcomes-of-very-preterm-infants-with-brain-injury
#5
Xue-Hua Zhang, Shi-Jun Qiu, Wen-Juan Chen, Xi-Rong Gao, Ya Li, Jing Cao, Jing-Jing Zhang
Background: Compared with full-term infants, very preterm infants are more vulnerable to injury and long-term disability and are at high risk of death. The predictive value of ultrasound and imaging on the neurodevelopment is one of the hot topics. This study aimed to investigate the relationship between cranial ultrasound (cUS) variables and neurodevelopmental outcomes of very preterm infants. Methods: Totally 129 very preterm infants (gestational age ≤28 weeks) in neonatal intensive care unit of Hunan Children's Hospital between January 2012 and November 2014 were included in this retrospective study...
April 20, 2018: Chinese Medical Journal
https://www.readbyqxmd.com/read/29627178/growth-morbidity-in-extremely-low-birth-weight-survivors-of-necrotizing-enterocolitis-at-discharge-and-two-year-follow-up
#6
Charles R Hong, Brenna S Fullerton, Charles E Mercier, Kate A Morrow, Erika M Edwards, Karla R Ferrelli, Roger F Soll, Biren P Modi, Jeffrey D Horbar, Tom Jaksic
PURPOSE: The purpose of this study was to examine postnatal growth outcomes and predictors of growth failure at 18-24months corrected age among extremely low birth weight (ELBW) survivors of necrotizing enterocolitis (NEC) compared to survivors without NEC. METHODS: Data were collected prospectively on ELBW (22-27weeks gestation or 401-1000g birth weight) infants born 2000-2013 at 46 centers participating in the Vermont Oxford Network follow-up project. Severe growth failure was defined as <3rd percentile weight-for-age...
March 8, 2018: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/29603412/improving-nutrition-outcomes-for-infants-1500-grams-with-a-progressive-evidenced-based-enteral-feeding-protocol
#7
Melissa K Thoene, Elizabeth Lyden, Ann Anderson-Berry
BACKGROUND: Growth is essential for very low birth weight infants. The purpose of this retrospective chart review was to evaluate the impact of a new standardized, evidenced-based feeding protocol for infants born < 1500 g in correlation with growth and clinical outcomes. METHODS: Growth and nutrition data was reviewed from 2 groups of infants born < 1500 g within a level III newborn intensive care unit (NICU). Epoch 1 infants (N = 32) received care following initial implementation of a standardized enteral feeding protocol...
March 30, 2018: Nutrition in Clinical Practice
https://www.readbyqxmd.com/read/29506014/effect-of-milking-maneuver-in-preterm-infants-a-randomized-controlled-trial
#8
Víctor Lago Leal, Loida Pamplona Bueno, Lucía Cabanillas Vilaplana, Estefanía Nicolás Montero, Mónica Martín Blanco, Cristina Fernández Romero, Sara El Bakkali, Tamara Pradillo Aramendi, Lara Sobrino Lorenzano, Paula Castellano Esparza, Esther Ballesteros Benito, Nieves Rayo Navarro, Pablo Del Barrio Fernández, Vanesa Ocaña Martínez, Luis Martínez Cortés
OBJECTIVE: To assess the short and medium-term effects of milking maneuver (MM) compared with early cord clamping for infants born before 37 weeks of pregnancy. MATERIAL AND METHODS: 138 infants between 24+0 and 36+6 weeks of gestation were allocated to MM or early cord clamping. Primary outcomes were the requirement of red blood cell transfusions or phototherapy. RESULTS: Initial hemoglobin was significantly higher in the MM group by 1.675 g/dL (p < 0...
March 5, 2018: Fetal Diagnosis and Therapy
https://www.readbyqxmd.com/read/29499303/chemerin-suppresses-neuroinflammation-and-improves-neurological-recovery-via-camkk2-ampk-nrf2-pathway-after-germinal-matrix-hemorrhage-in-neonatal-rats
#9
Yixin Zhang, Ningbo Xu, Yan Ding, Yiting Zhang, Qian Li, Jerry Flores, Mina Haghighiabyaneh, Desislava Doycheva, Jiping Tang, John H Zhang
Chemerin, an adipokine, has been reported to reduce the production of pro-inflammatory cytokines and neutrophil infiltration. This study investigated the role of Chemerin and its natural receptor, ChemR23, as well as its downstream mediator calmodulin-dependent protein kinase kinase 2 (CAMKK2)/adenosine monophosphate-activated protein kinase (AMPK) /Nuclear factor erythroid 2-related factor 2 (Nrf2) following germinal matrix hemorrhage (GMH) in neonatal rats, with a specific focus on inflammation. GMH was induced by intraparenchymal injection of bacterial collagenase (0...
May 2018: Brain, Behavior, and Immunity
https://www.readbyqxmd.com/read/29462812/survival-rate-without-brain-abnormalities-on-postnatal-ultrasonography-among-monochorionic-twins-after-fetoscopic-laser-photocoagulation-for-selective-intrauterine-growth-restriction-with-concomitant-oligohydramnios
#10
Keisuke Ishii, Seiji Wada, Mayumi Takano, Masahiko Nakata, Takeshi Murakoshi, Haruhiko Sago
INTRODUCTION: We aimed to clarify the survival rate without brain abnormalities (BA) after fetoscopic laser photoco-agulation (FLP) for monochorionic diamniotic twin gestations (MCDA) with selective intrauterine growth restriction (sIUGR) accompanied by abnormal umbilical artery (UA) Doppler waveforms and isolated oligohydramnios in the sIUGR twin. MATERIALS AND METHODS: This retrospective study included 52 cases that underwent FLP. The main outcome was survival rate without BA of the twins at age 28 days...
February 20, 2018: Fetal Diagnosis and Therapy
https://www.readbyqxmd.com/read/29460549/igm-and-iga-enriched-polyclonal-immunoglobulins-reduce-short-term-mortality-in-extremely-low-birth-weight-infants-elbw-with-sepsis-a-retrospective-cohort-study
#11
Letizia Capasso, Angela C Borrelli, Maria R Pirozzi, Laura Bucci, Roberta Albachiara, Teresa Ferrara, Francesco Raimondi
BACKGROUND: Immunoglobulin supplementation is a debated strategy in fighting sepsis. We evaluated a polyclonal IgM and IgA enriched immunoglobulin (IgMeIVIG) preparation in reducing the short term mortality in extremely low birth weight neonates (ELBW) with proven infection. METHODS: ELBW infants born from January 2008 to December 2014 were eligible for this retrospective casecontrol analysis if they were symptomatic and had a positive blood culture after 72hours of life...
February 19, 2018: Minerva Pediatrica
https://www.readbyqxmd.com/read/29460006/mechanical-disruption-of-the-blood-brain-barrier-following-experimental-concussion
#12
Victoria E Johnson, Maura T Weber, Rui Xiao, D Kacy Cullen, David F Meaney, William Stewart, Douglas H Smith
Although concussion is now recognized as a major health issue, its non-lethal nature has limited characterization of the underlying pathophysiology. In particular, potential neuropathological changes have typically been inferred from non-invasive techniques or post-mortem examinations of severe traumatic brain injury (TBI). Here, we used a swine model of head rotational acceleration based on human concussion to examine blood-brain barrier (BBB) integrity after injury in association with diffuse axonal injury and glial responses...
May 2018: Acta Neuropathologica
https://www.readbyqxmd.com/read/29459939/cognitive-outcomes-of-children-born-extremely-or-very-preterm-since-the-1990s-and-associated-risk-factors-a-meta-analysis-and-meta-regression
#13
E Sabrina Twilhaar, Rebecca M Wade, Jorrit F de Kieviet, Johannes B van Goudoever, Ruurd M van Elburg, Jaap Oosterlaan
Importance: Despite apparent progress in perinatal care, children born extremely or very preterm (EP/VP) remain at high risk for cognitive deficits. Insight into factors contributing to cognitive outcome is key to improve outcomes after EP/VP birth. Objective: To examine the cognitive abilities of children of EP/VP birth (EP/VP children) and the role of perinatal and demographic risk factors. Data Sources: PubMed, Web of Science, and PsycINFO were searched without language restriction (last search March 2, 2017)...
April 1, 2018: JAMA Pediatrics
https://www.readbyqxmd.com/read/29425978/intraventricular-epithelioid-glioblastoma-a-case-report
#14
Naoki Nitta, Suzuko Moritani, Tadateru Fukami, Yayoi Yoshimura, Hisao Hirai, Kazuhiko Nozaki
BACKGROUND: Epithelioid glioblastoma, a high-grade, diffuse astrocytic tumor variant, comprises closely packed epithelioid cells and rhabdoid cells. This rare tumor usually develops in the cerebral cortex and diencephalon; however, in the case reported here, it was located intraventricularly. CASE DESCRIPTION: A 47-year-old woman was referred to our hospital with a right intraventricular mass that had rapidly increased in size. On discovery of the tumor 3 years earlier at the referring hospital, the mass was small, calcified, and attached to the periventricular parenchyma...
April 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29395186/antecedents-and-outcomes-of-abnormal-cranial-imaging-in-moderately-preterm-infants
#15
Girija Natarajan, Seetha Shankaran, Shampa Saha, Abbot Laptook, Abhik Das, Rosemary Higgins, Barbara J Stoll, Edward F Bell, Waldemar A Carlo, Carl D'Angio, Sara B DeMauro, Pablo Sanchez, Krisa Van Meurs, Betty Vohr, Nancy Newman, Ellen Hale, Michele Walsh
OBJECTIVES: To describe the frequency and findings of cranial imaging in moderately preterm infants (born at 290/7 -336/7 weeks of gestation) across centers, and to examine the association between abnormal imaging and clinical characteristics. STUDY DESIGN: We used data from the Neonatal Research Network Moderately Preterm Registry, including the most severe early (≤28 days) and late (>28 days) cranial imaging. Stepwise logistic regression and CART analysis were performed after adjustment for gestational age, antenatal steroid use, and center...
April 2018: Journal of Pediatrics
https://www.readbyqxmd.com/read/29392647/evaluation-of-symmetrical-increased-echogenicity-of-bilateral-caudothalamic-grooves-detected-on-cranial-ultrasonography-by-comparing-with-susceptibility-weighted-imaging
#16
Mehmet S Dogan, Gonca Koc, Selim Doganay, Sumeyra Dogan, Ahmet Özdemir, Levent Korkmaz, Abdulhakim Coskun
OBJECTIVE: To assess symmetrical increased echogenicity of bilateral caudothalamic grooves (SIEBCG) detected on newborn cranial ultrasonography (CUS) using magnetic resonance susceptibility-weighted imaging (SWI). MATERIALS AND METHODS: A total of 14 newborns (8 girls; 12 premature with mean gestational age of 30 weeks and 5 days, 2 mature) who were detected to have SIEBCG on routine serial CUS and underwent cranial magnetic resonance imaging (MRI) were recruited for the study...
February 1, 2018: La Radiologia Medica
https://www.readbyqxmd.com/read/29337005/walker-warburg-syndrome-and-tectocerebellar-dysraphia-a-novel-association-caused-by-a-homozygous-dag1-mutation
#17
Zvi Leibovitz, Hanna Mandel, Tzipora C Falik-Zaccai, Shani Ben Harouch, David Savitzki, Karina Krajden-Haratz, Liat Gindes, Mordechai Tamarkin, Dorit Lev, William B Dobyns, Tally Lerman-Sagie
OBJECTIVES: To elaborate the imaging phenotype associated with a homozygous c.743C > del frameshift mutation in DAG1 leading to complete absence of both α- and β-dystroglycan previously reported in a consanguineous Israeli-Arab family. METHODS: We analyzed prenatal and postnatal imaging data of patients from a consanguineous Israeli-Arab kindred harboring the DAG1 mutation. RESULTS: The imaging studies (fetal ultrasound, CT scan and postnatal MRI) demonstrated: flat cortex (abnormally thick with irregular pebbled cortical-white matter border on MRI), hydrocephalus, scattered small periventricular heterotopia and subependymal hemorrhages and calcifications, z-shaped brainstem, and in addition an occipital encephalocele, vermian agenesis, and an elongated and thick tectum (tectocerebellar dysraphia)...
May 2018: European Journal of Paediatric Neurology: EJPN
https://www.readbyqxmd.com/read/29311628/vascular-placental-pathology-and-the-relationship-between-hypertensive-disorders-of-pregnancy-and-neonatal-outcomes-in-very-low-birth-weight-infants
#18
Lisa Strouss, Neal D Goldstein, Robert Locke, David A Paul
OBJECTIVE: To investigate vascular placental pathology's effect on known associations between hypertensive disorders and four adverse neonatal outcomes-bronchopulmonary dysplasia, intraventricular hemorrhage or periventricular leukomalacia, necrotizing enterocolitis, and death. STUDY DESIGN: Retrospective cohort of very low birth weight neonates born at a single center (n = 911). Statistical analysis included χ2 , t test, modified Poisson regression with robust error variance to measure risk, and Wald test...
January 8, 2018: Journal of Perinatology: Official Journal of the California Perinatal Association
https://www.readbyqxmd.com/read/29279020/short-term-outcomes-comparison-between-preterm-infants-with-and-without-acute-hypoxic-respiratory-failure-attributable-to-presumed-pulmonary-hypoplasia-after-prolonged-preterm-premature-rupture-of-membranes-before-25-gestational-weeks
#19
Ga Young Park, Won Soon Park, Hye Soo Yoo, So Yoon Ahn, Se In Sung, Sung Shin Kim, Yun Sil Chang
OBJECTIVE: To determine the updated outcomes of preterm infants with acute hypoxic respiratory failure attributable to presumed pulmonary hypoplasia (PH) following maternal midtrimester prolonged preterm premature rupture of membranes (PPROM). STUDY DESIGN: Among preterm infants with birthweight <1500 g and 23-34 weeks gestational age in a single center, infants exposed to maternal prolonged (≥7 days) PPROM before 25 gestational weeks (PPPROM25, n = 76) were retrospectively reviewed...
January 8, 2018: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/29187166/what-is-the-safest-mode-of-delivery-for-extremely-preterm-cephalic-non-cephalic-twin-pairs-a-systematic-review-and-meta-analyses
#20
Catherine Dagenais, Anne-Mary Lewis-Mikhael, Marinela Grabovac, Amit Mukerji, Sarah D McDonald
BACKGROUND: Given the controversy around mode of delivery, our objective was to assess the evidence regarding the safest mode of delivery for actively resuscitated extremely preterm cephalic/non-cephalic twin pairs before 28 weeks of gestation. METHODS: We searched Cochrane CENTRAL, MEDLINE, EMBASE and  http://clinicaltrials.gov from January 1994 to January 2017. Two reviewers independently screened titles, abstracts and full text articles, extracted data and assessed risk of bias...
November 29, 2017: BMC Pregnancy and Childbirth
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