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JOURNAL ARTICLE
Haixin Ju, Minghui Yu, Xuanjin Du, Shanshan Xue, Ningli Ye, Lei Sun, Xiaohui Wu, Hong Xu, Qian Shen
Gestational diabetes mellitus (GDM) presents a substantial population health concern. Previous studies have revealed that GDM can ultimately influence nephron endowment. In this study, we established a GDM mouse model to investigate the embryological alterations and molecular mechanisms underlying the development of congenital anomalies of the kidney and urinary tract (CAKUT) affected by GDM. Our study highlights that GDM could contribute to the manifestation of CAKUT, with prevalent phenotypes characterized by isolated hydronephrosis and duplex kidney complicated with hydronephrosis in mice...
April 16, 2024: Biochemical and Biophysical Research Communications
#2
JOURNAL ARTICLE
Gilad Hamdani, Noga Yaniv Mhi, Shoval Marton, Yael Borovitz, Shelly Levi, Daniel Landau, Amit Dagan
OBJECTIVE: To evaluate the risk for urinary tract infection (UTI) in infants with isolated hydronephrosis (IH). STUDY DESIGN: A retrospective, population-based study including all infants insured by Clalit Health Services (CHS) and followed from birth to age 2 years in 3 regions of central Israel. Infants were divided into 3 groups based on electronic medical record (EMR) diagnoses by age 6 months: 1) control - no urological diagnosis; 2) IH; and 3) "complicated urological diagnosis" (CUD): any additional nephrological/urological diagnosis with/without HN...
April 11, 2024: Journal of Pediatrics
#3
JOURNAL ARTICLE
Dominika Borselle, Maciej Kaczorowski, Bartosz Gogolok, Dariusz Patkowski, Marcin Polok, Agnieszka Hałoń, Wojciech Apoznański
Introduction : Etiopathogenesis and the symptomatology of ureteropelvic junction obstruction (UPJO) in the pediatric population has not yet been definitely clarified, suggesting a multifactorial nature of the condition. The aim was to analyze the association between the number of Interstitial Cells of Cajal (ICCs), as well as P2 X3 receptors in ureteropelvic junction (UPJ) and the pain response in pediatric patients with hydronephrosis. Methods: 50 patients with congenital hydronephrosis underwent open or laparoscopic pyeloplasty at one of two departments of pediatric surgery and urology in Poland...
April 4, 2024: Journal of Clinical Medicine
#4
JOURNAL ARTICLE
Yousuf Al-Shaqsi, Matthieu Peycelon, Annabel Paye-Jaouen, Elisabeth Carricaburu, Anca Tanase, Christine Grapin-Dagorno, Alaa El-Ghoneimi
BACKGROUND: Ureteropelvic junction obstruction (UPJO) is a common congenital urinary tract disorder in children. It can be diagnosed as early as in utero due to the presence of hydronephrosis or later in life due to symptomatic occurrence. AIM: To evaluate the discrepancy between dynamic contrast-enhanced magnetic resonance urography (dMRU) and scintigraphy 99m-technetium mercaptoacetyltriglycine (MAG-3) for the functional evaluation of UPJO. METHODS: Between 2016 and 2020, 126 patients with UPJO underwent surgery at Robert Debré Hospital...
March 28, 2024: World Journal of Radiology
#5
JOURNAL ARTICLE
Kelsey R Clearman, Napassawon Timpratoom, Dharti Patel, Addison B Rains, Courtney J Haycraft, Mandy J Croyle, Jeremy F Reiter, Bradley K Yoder
BACKGROUND: Rab35 is a member of a GTPase family of endocytic trafficking proteins. Studies in cell lines have indicated that Rab35 participates in cell adhesion, polarity, cytokinesis, and primary cilia length and composition. Additionally, sea urchin Rab35 regulates actin organization and is required for gastrulation. In mice, loss of Rab35 in the CNS disrupts hippocampal development and neuronal organization. Outside of the CNS, the functions of mammalian Rab35 in vivo are unknown...
March 26, 2024: Journal of the American Society of Nephrology: JASN
#6
JOURNAL ARTICLE
Fabian Ebach, Pauline Wagner, Raimund Stein, Ramona Dolscheid-Pommerich, Heiko Reutter, Alina C Hilger
BACKGROUND: Congenital lower urinary tract obstruction (LUTO) describes a heterogeneous group of congenital malformations. Posterior urethral valves (PUV) represent the most common entity. Familial occurrence has been described, suggestive of underlying genetic factors. LUTO can occur in various degrees of severity. In severe forms, oligohydramnios, pulmonary hypoplasia, and renal damage can occur resulting in high pre- and postnatal mortality. On the contrary, mild forms may become apparent through recurrent urinary tract infections...
March 2024: Health Science Reports
#7
JOURNAL ARTICLE
Amr Hodhod, Hadeel Eid, Carolina Fermin-Risso, Mutaz Farhad, Jarah Aburezq, Anthony Cook, Bryce Weber
INTRODUCTION: Pyeloplasty is the definitive management of ureteropelvic junction obstruction (UPJO). One of the challenging questions is when to perform pyeloplasty. We studied if improvement post-pyeloplasty in the first 3 months of life could show greater improvement in hydronephrosis than surgery at an older age. PATIENTS AND METHODS: Patients with postnatally diagnosed UPJO and underwent pyeloplasty in the first year of life were retrospectively reviewed. We excluded patients with concomitant vesicoureteral reflux, and patients who had pyeloplasty because of UTI or missed follow-up...
March 20, 2024: International Urology and Nephrology
#8
JOURNAL ARTICLE
Leon Chertin, Binyamin B Neeman, Jawdat Jaber, Guy Verhovsky, Amnon Zisman, Ariel Mamber, Ilan Kafka, Ala Eddin Natsheh, Dmitry Koulikov, Ofer Z Shenfeld, Boris Chertin, Stanislav Koucherov, Amos Neheman
PURPOSE: To summarize our experience in the management of congenital anomalies in the kidney and urinary tract (CAKUT) in adults. MATERIALS AND METHODS: We conducted a retrospective chart review of all adult patients who underwent primary surgical intervention for CAKUT between 1998 and 2021. RESULTS: The study included 102 patients with a median age of 25 (interquartile range, 23-36.5). Of these, 85 (83.3%) patients reported normal prenatal ultrasound, and the remaining 17 (16...
March 2024: Current Urology
#9
REVIEW
Giulio Rivetti, Pierluigi Marzuillo, Stefano Guarino, Anna Di Sessa, Angela La Manna, Anthony A Caldamone, Alfonso Papparella, Carmine Noviello
UNLABELLED: Primary non-refluxing megaureter (PMU) is a congenital dilation of the ureter which is not related to vesicoureteral reflux, duplicated collecting systems, ureterocele, ectopic ureter, or posterior urethral valves and accounts for 5 to 10% of all prenatal hydronephrosis (HN) cases. The etiology is a dysfunction or stenosis of the distal ureter. Most often PMU remains asymptomatic with spontaneous resolution allowing for non-operative management. Nevertheless, in selective cases such as the development of febrile urinary tract infections, worsening of the ureteral dilatation, or reduction in relative renal function, surgery should be considered...
March 5, 2024: European Journal of Pediatrics
#10
Kristel Sibaja, Harper Henderson, Alejandro Biglione, RaeAnn Tourangeau-Young
Abnormalities in renal fusion represent a subset of congenital anomalies of the kidneys and urinary tract (CAKUT). Horseshoe kidneys (HSKs) are the fusion of kidneys at their lower poles. It is the most common form of CAKUT. Symptoms are usually subtle. The diagnosis is usually made incidentally during childhood. Rarely does an HSK become symptomatic later in life. We present the case of an 88-year-old female with a history of HSK who presented to the emergency department (ED) with a three-week history of left-sided flank pain, intermittent nausea, and reduced urine output...
January 2024: Curēus
#11
Lei Liang, Haotian Wu, Haixia Meng, Lin Fu, Jianrong Zhao
Primary vesicoureteral reflux (VUR) is the prevailing congenital anomaly of the kidneys and urinary tract, posing a significant risk for pyelonephritis scarring and chronic renal insufficiency in pediatric patients. Nevertheless, the precise genetic etiology of VUR remains enigmatic. In this current investigation, we conducted whole-exome sequencing on a child exhibiting single kidney, devoid of any familial VUR background, along with both biological parents. Two missense variants (NM_019105.8: exon11: c.4111G>A and NM_019105...
2024: Frontiers in Endocrinology
#12
JOURNAL ARTICLE
Shun Onishi, Koji Yamada, Masakazu Murakami, Toshio Harumatsu, Takafumi Kawano, Satoshi Ieiri
A boy with congenital hydronephrosis underwent ultrasonography every month for follow-up. At 4 months of age, ultrasonography incidentally revealed congenital biliary dilatation (5-cm type Ia). We performed laparoscopic extrahepatic bile duct resection and hepaticojejunostomy. After dissecting the dilated common bile duct (CBD), we found that the arcading-like shaped right hepatic artery (RHA) coursed in front of the CBD. Additionally, a tiny duct was identified below the main hepatic duct. At first, we thought it was a lymphatic vessel and dissected it from the main hepatic duct...
January 2024: European Journal of Pediatric Surgery Reports
#13
JOURNAL ARTICLE
Yosuke Morizawa, Katsuya Aoki, Shinji Fukui, Mitsuru Tomizawa, Takuto Shimizu, Kenta Onishi, Shunta Hori, Daisuke Gotoh, Yasushi Nakai, Makito Miyake, Kazumasa Torimoto, Ken Fujimoto, Takeshi Otani, Kiyohide Fujimoto
OBJECTIVES: Many congenital hydronephroses spontaneously resolve. This study evaluated a long-term follow-up of more than 4 years of patients with congenital hydronephrosis at a single center. METHODS: In total, 215 patients (286 kidneys) with congenital hydronephrosis were included. Hydronephrosis outcomes (resolution, improvement, and persistence) and time-to-outcome were evaluated. RESULTS: Fourteen patients underwent early surgical intervention until the age of 2 years...
January 11, 2024: International Journal of Urology: Official Journal of the Japanese Urological Association
#14
JOURNAL ARTICLE
Sonia Sharma, Shailesh Gupta, A P Mehta, Poonam Sidana
Galactosialidosis (GS) is a rare lysosomal storage disorder. We reported here, the case of a 29-day-old boy who had increased body swelling, difficulty breathing, and petechiae on the trunk since birth. The antenatal history was unremarkable. Clinical laboratory findings included coarse facies, hepatosplenomegaly, gross ascites, thrombocytopenia, nephrotic range proteinuria, and bilateral hydronephrosis. The diagnostic challenge was resolved after genetic testing, which revealed GS with a novel homozygous c...
December 2023: Journal of Pediatric Genetics
#15
JOURNAL ARTICLE
Juliana Marin Fontes, Emmanuel Machado Oliveira, Tereza Cristina Monteiro de Melo Prazeres, Glaura Nisya de Oliveira Cruz, Marta Rizzini, Saulo Duarte Passos, Lilian Lira Lisboa, Grace Ferreira de Araújo, Valéria Azevedo de Almeida, Jociele Malacarne, Maria Emília de Domenico Garcia, Lilian Cagliari Linhares Barreto, Adriano Almeida Calado, Luciana Fernandes da Nóbrega, Maria Júlia Moura Nascimento Santos, Rafael Pauletti Gonçalves, Luana Farache, Maurício Feliciano da Silva, Fábio Valente Rizzo, Luiz Dias da Silva, Nilgicy Maria de Jesus Amorim, Hannah Cavalcante Guedes Pinheiro, Adriana Suely de Oliveira Melo, Fabiana de Oliveira Melo, Rômulo Dias Moreira, Benito Junior Santos da Costa, Melissa de Almeida Melo Maciel Mangueira, Margareth Catoia Varela, Lucia Maria Costa Monteiro
INTRODUCTION: Neurogenic bladder was first confirmed as a urological sequela of Congenital Zika Syndrome (CZS) in 2018. Further clinical-epidemiological evidence also confirmed neurogenic bowel dysfunction and cryptorchidism. To strengthen the care for these children, the Congenital Zika Virus Bladder and Bowel Sequelae Network (RASZ in Brazilian) was created, including six integrated centers in Brazil. This article represents the initial outcome of the efforts by RASZ. OBJECTIVE: To evaluate the prevalence of bladder and bowel dysfunction, cryptorchidism and other urological sequelae related to CZS in cohorts attended in six Brazilian states...
November 23, 2023: Journal of Pediatric Urology
#16
REVIEW
Daniel Ortiz-Seller, Jorge Panach-Navarrete, Lorena Valls-González, José María Martínez-Jabaloyas
INTRODUCTION: Ureteropelvic junction obstruction (UPJO) is the most common cause of congenital hydronephrosis. Techniques such as laparoscopic pyeloplasty (LP) have gained in popularity over recent years. Although some retrospective studies have compared minimally invasive reconstructive techniques with open surgery for treatment of UPJO in infants, results remain controversial due to the small sample size in most of these studies. OBJECTIVE: To verify whether the benefits of minimally invasive pyeloplasty (MIP) observed in adults and children over 2 years of age also apply to infants...
November 23, 2023: Journal of Pediatric Urology
#17
JOURNAL ARTICLE
Bayan Shalash, Michael Ernst, Megan Stout, Lindsey Asti, Daryl J McLeod
OBJECTIVES: To improve the predictive ability of diuretic renography (DR) for surgical intervention in children with congenital hydronephrosis (CH) and concern for Ureteropelvic Junction Obstruction. METHODS: Children with CH born between 2007 and 2021 who underwent initial DR prior to 6 months of life, had both clearance while upright (CUP) and T ½ reported, and did not have immediate surgical intervention after the first DR were retrospectively evaluated for surgical intervention during the period of clinical observation...
November 29, 2023: Urology
#18
JOURNAL ARTICLE
Hsin-Hsiao Scott Wang, Michael Li, Dylan Cahill, John Panagides, Tanya Logvinenko, Jeanne Chow, Caleb Nelson
BACKGROUNDS: Urinary Tract Dilation (UTD) classification has been designed to be a more objective grading system to evaluate antenatal and post-natal UTD. Due to unclear association between UTD classifications to specific anomalies such as vesico-ureteral reflux (VUR), management recommendations tend to be subjective. OBJECTIVE: We sought to develop a model to reliably predict VUR from early post-natal ultrasound. STUDY DESIGN: Radiology records from single institution were reviewed to identify infants aged 0-90 days undergoing early ultrasound for antenatal UTD...
November 9, 2023: Journal of Pediatric Urology
#19
JOURNAL ARTICLE
Eric J Robinson, Aaron Bayne
PURPOSE: To determine if children with UPJO demonstrate a clinically significant change in somatic growth following pyeloplasty. METHODS: We retrospectively evaluated the growth chart data of infants with SFU grade 3 or 4 congenital hydronephrosis at our institution from 2015 to 2022. Of those, 35 patients underwent pyeloplasty and 66 had no surgical intervention. Patients met criteria if they had SFU 3 or 4 hydronephrosis and MAG3 renal scan. If patients underwent surgery, height and weight percentiles were recorded from the pre-op and 6-16-month follow-up visits...
November 22, 2023: International Urology and Nephrology
#20
Soo Jin Lee, Seok Young Cho, Wonkyo Yi, Kyung Pyo Kang
Anorectal malformations (ARMs) comprise a broad spectrum of congenital anomalies involving both anorectal and urogenital tracts. After diagnosis, urological problems should be evaluated in addition to surgical correction of ARMs. Commonly encountered urological problems in patients with ARMs are recurrent urinary tract infections, vesicoureteral reflux, and chronic kidney disease. Therefore, the proper timing of urination and appropriate defecation habits are essential for preserving renal function in patients with ARMs...
October 2023: Curēus
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