Brittany P Marshall, Beth G Ashinsky, Xavier E Ferrer, Jennifer A Kunes, Astia C Innis, Andrew J Luzzi, Lynn Ann Forrester, Kevin G Burt, Andy J Lee, Lee Song, Lauren E Lisiewski, Rajesh K Soni, Clark T Hung, William N Levine, David Kovacevic, Stavros Thomopoulos
Rotator cuff injuries result in more than 500,000 surgeries annually in the United States, many of which fail. These surgeries typically involve repair of the injured tendon and removal of the subacromial bursa, a synovial-like tissue that sits between the rotator cuff and the acromion. The subacromial bursa has been implicated in rotator cuff pathogenesis and healing. Using proteomic profiling of bursa samples from nine patients with rotator cuff injury, we show that the bursa responds to injury in the underlying tendon...
April 24, 2024: Science Translational Medicine