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https://www.readbyqxmd.com/read/28110486/spectra-optia-%C3%A2-for-automated-red-blood-cell-exchange-in-patients-with-sickle-cell-disease-a-nice-medical-technology-guidance
#1
REVIEW
Iain Willits, Helen Cole, Roseanne Jones, Kimberley Carter, Mick Arber, Michelle Jenks, Joyce Craig, Andrew Sims
The Spectra Optia(®) automated apheresis system, indicated for red blood cell exchange in people with sickle cell disease, underwent evaluation by the National Institute for Health and Care Excellence, which uses its Medical Technologies Advisory Committee to make recommendations. The company (Terumo Medical Corporation) produced a submission making a case for adoption of its technology, which was critiqued by the Newcastle and York external assessment centre. Thirty retrospective observational studies were identified in their clinical submission...
January 21, 2017: Applied Health Economics and Health Policy
https://www.readbyqxmd.com/read/28110432/two-by-two-cross-over-study-to-evaluate-agreement-between-versions-of-a-quantitative-coronary-analysis-system-qangio-xa
#2
Kayoko Kozuma, Kosuke Kashiwabara, Tomohiro Shinozaki, Ken Kozuma, Koji Oba, Yutaka Matsuyama
The current version (ver. 7.3) of the popular quantitative coronary analysis system QAngio XA (Medis Medical Imaging System BV, Leiden, the Netherlands) is widely used without evaluating the agreement between the current and older versions in relation to a change of algorithms. The purpose of this study was to assess the equivalence of averages between QAngio XA versions 7.3 and 6.0. Based on the calculated sample size, angiographic images of 100 patients who underwent percutaneous coronary intervention of a single target lesion were randomly selected from two published studies (OUCH-TL: 154 lesions; OUCH-PRO: 160 lesions)...
January 21, 2017: International Journal of Cardiovascular Imaging
https://www.readbyqxmd.com/read/28110401/evaluating-the-utility-of-a-scoring-system-for-lipomas-of-the-cerebellopontine-angle
#3
Carlito Lagman, Brittany L Voth, Lawrance K Chung, Timothy T Bui, Seung J Lee, Natalie E Barnette, Quinton Gopen, Isaac Yang
BACKGROUND: Cerebellopontine angle (CPA) lipomas are rare, benign, slow-growing masses. Resections are considered in symptomatic patients who are refractory to targeted medical therapies, but at those stages the lipomas have often reached considerable sizes and encompass critical neurovascular structures. The objective of this study is to develop and to evaluate the utility of a scoring system for CPA lipomas. The hypothesis is that CPA lipomas with lower scores are probably best managed with early surgery...
January 21, 2017: Acta Neurochirurgica
https://www.readbyqxmd.com/read/28110361/the-impact-of-routine-whole-spine-mri-screening-in-the-evaluation-of-spinal-degenerative-diseases
#4
Rishi Mugesh Kanna, Younis Kamal, Anupama Mahesh, Prakash Venugopal, Ajoy Prasad Shetty, S Rajasekaran
PURPOSE: Magnetic resonance imaging (MRI) of the spine is a sensitive investigation, which not only provides detailed images of the spinal column but also adjacent spinal regions and para-vertebral organ systems. Such incidental findings (IF) can be asymptomatic but significant. The efficacy of whole spine T2 sagittal screening in providing additional information has been demonstrated in several spinal diseases but its routine use in patients with spinal degenerative diseases has not been studied...
January 21, 2017: European Spine Journal
https://www.readbyqxmd.com/read/28110290/guided-and-unguided-internet-based-vestibular-rehabilitation-versus-usual-care-for-dizzy-adults-of-50%C3%A2-years-and-older-a-protocol-for-a-three-armed-randomised-trial
#5
Vincent A van Vugt, Johannes C van der Wouden, Judith E Bosmans, Martin Smalbrugge, Willianne van Diest, Rosie Essery, Lucy Yardley, Henriëtte E van der Horst, Otto R Maarsingh
INTRODUCTION: Dizziness is a common symptom in general practice with a high prevalence among older adults. The most common cause of dizziness in general practice is peripheral vestibular disease. Vestibular rehabilitation (VR) is a safe and effective treatment for peripheral vestibular disease that entails specific exercises to maximise the central nervous system compensation for the effects of vestibular pathology. An internet-based VR intervention has recently been shown to be safe and effective...
January 20, 2017: BMJ Open
https://www.readbyqxmd.com/read/28110283/estimated-generic-prices-of-cancer-medicines-deemed-cost-ineffective-in-england-a-cost-estimation-analysis
#6
Andrew Hill, Christopher Redd, Dzintars Gotham, Isabelle Erbacher, Jonathan Meldrum, Ryo Harada
OBJECTIVES: The aim of this study was to estimate lowest possible treatment costs for four novel cancer drugs, hypothesising that generic manufacturing could significantly reduce treatment costs. SETTING: This research was carried out in a non-clinical research setting using secondary data. PARTICIPANTS: There were no human participants in the study. Four drugs were selected for the study: bortezomib, dasatinib, everolimus and gefitinib. These medications were selected according to their clinical importance, novel pharmaceutical actions and the availability of generic price data...
January 20, 2017: BMJ Open
https://www.readbyqxmd.com/read/28110256/ethical-experiential-learning-in-medical-nursing-and-allied-health-education-a-narrative-review
#7
REVIEW
Sandra Grace, Ev Innes, Narelle Patton, Lynette Stockhausen
: Students enrolled in medical, nursing and health science programs often participate in experiential learning in their practical classes. Experiential learning includes peer physical examination and peer-assisted learning where students practise clinical skills on each other. OBJECTIVES: To identify effective strategies that enable ethical experiential learning for health students during practical classes. DESIGN: A narrative review of the literature...
January 10, 2017: Nurse Education Today
https://www.readbyqxmd.com/read/28110111/applying-a-novel-statistical-method-to-advance-the-personalized-treatment-of-anxiety-disorders-a-composite-moderator-of-comparative-drop-out-from-cbt-and-act
#8
Andrea N Niles, Kate B Wolitzky-Taylor, Joanna J Arch, Michelle G Craske
BACKGROUND: No prior studies have examined moderators of dropout between distinct treatments for anxiety disorders. This study applied a novel statistical approach for examining moderators of dropout from traditional cognitive behavioral therapy (CBT) and acceptance and commitment therapy (ACT). METHOD: We combined data from two randomized controlled trials (N = 208) comparing CBT and ACT for patients with DSM-IV anxiety disorders. Adapting Kraemer's method for constructing and evaluating composite moderators (2013), 26 variables were examined for individual effect sizes...
January 4, 2017: Behaviour Research and Therapy
https://www.readbyqxmd.com/read/28110051/reliability-of-self-reported-recent-antibiotic-use-among-the-general-population-a-cross-sectional-study
#9
Béatrice Demore, Diane Le Govic, Nathalie Thilly, Jean-Marc Boivin, Céline Pulcini
OBJECTIVES: Evaluate the reliability of self-reported recent antibiotic use, including ability to name the antibiotic, among pharmacy customers from the general population. METHODS: This cross-sectional observational study of adults took place in pharmacies in northeastern France from January to April 2016. Participants were asked if they had used any antibiotics in the preceding four months and if so, to name them. Their reports were compared with an electronic pharmacy dispensing record listing all of the medication dispensed to them in France...
January 18, 2017: Clinical Microbiology and Infection
https://www.readbyqxmd.com/read/28109993/epilepsy-associated-levels-of-perceived-stigma-their-associations-with-treatment-and-related-factors-a-cross-sectional-study-in-urban-and%C3%A2-rural-areas-in-ecuador
#10
Jaime Luna, Mandy Nizard, Danielle Becker, Daniel Gerard, Alejandro Cruz, Voa Ratsimbazafy, Michel Dumas, Marcelo Cruz, Pierre-Marie Preux
BACKGROUND: Epilepsy is felt to be a stigmatizing condition. Stigma has been considered one of the major factors contributing to the burden of epilepsy and to the treatment gap. Stigma has a negative effect on the management of people with epilepsy (PWE). Furthermore, lack of information and inappropriate beliefs are still the factors that most contribute to stigma and discrimination. In this study, we assessed the level of perceived stigma in urban and rural areas and we report their association with in antiepileptic drug (AED) use, effects on seeking medical care, and stigma-associated factors...
January 18, 2017: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/28109939/peripheral-venous-catheter-insertion-simulation-training-a-randomized-controlled-trial-comparing-performance-after-instructor-led-teaching-versus-peer-assisted-learning
#11
Sophie Pelloux, Arnaud Grégoire, Patrice Kirmizigul, Sandrine Maillot, Bernard Bui-Xuan, Guy Llorca, Sylvain Boet, Jean-Jacques Lehot, Thomas Rimmelé
INTRODUCTION: Peripheral venous catheter insertion is a procedural skill that every medical student should master. Training is often limited to a small number of students and is poorly evaluated. The objective of this study was to evaluate the performance of peer-assisted learning in comparison to instructor-led teaching for peripheral venous catheter insertion training. METHODS: Students were randomized to the control group attending a traditional instructor-led training session (slideshow and demonstration by an anaesthetist instructor, followed by training on a procedural simulator) or to the test group attending a peer-assisted training session (slideshow and demonstration video-recorded by the same instructor, followed by training on a procedural simulator...
January 18, 2017: Anaesthesia, Critical Care & Pain Medicine
https://www.readbyqxmd.com/read/28109918/%C3%AE-ct-based-trabecular-anisotropy-can-be-reproducibly-computed-from-hr-pqct-scans-using-the-triangulated-bone-surface
#12
Hadi S Hosseini, Ghislain Maquer, Philippe K Zysset
The trabecular structure can be assessed at the wrist or tibia via high-resolution peripheral quantitative computed tomography (HR-pQCT). Yet on this modality, the performance of the existing methods, evaluating trabecular anisotropy is usually overlooked, especially in terms of reproducibility. We thus proposed to compare the TRI routine used by SCANCO Medical AG (Brüttisellen, Switzerland), the classical mean intercept length (MIL), and the grey-level structure tensor (GST) to the mean surface length (MSL), a new method for evaluating a second-order fabric tensor based on the triangulation of the bone surface...
January 18, 2017: Bone
https://www.readbyqxmd.com/read/28109733/course-of-participation-after-subarachnoid-hemorrhage
#13
Elize M Kruisheer, Irene M C Huenges Wajer, Johanna M A Visser-Meily, Marcel W M Post
OBJECTIVES: The study aimed to investigate participation problems in patients with subarachnoid hemorrhage (SAH), and the course of participation between 3 and 12 months post-SAH, and to identify determinants of this course. DESIGN: This is a prospective cohort study. SETTING: The study was done in the SAH outpatient clinic at the University Medical Center Utrecht. SUBJECTS: Subjects included patients independent in activities of daily living who visited the SAH outpatient clinic for a routine follow-up visit 3 months after the event...
January 18, 2017: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
https://www.readbyqxmd.com/read/28109292/training-a-medical-workforce-to-meet-the-needs-of-diverse-minority-communities
#14
Faafetai Sopoaga, Tony Zaharic, Jesse Kokaua, Sahra Covello
BACKGROUND: The growing demand for a competent health workforce to meet the needs of increasingly diverse societies has been widely acknowledged. One medical school in New Zealand explored the integration of the commonly used patient-centred model approach, with an intersectional framework in the development of a cultural competency training programme. In the Pacific Immersion Programme, medical students in their fourth year of training are given the opportunity to learn about different factors that influence the health and health care of a minority community through immersion in that community...
January 21, 2017: BMC Medical Education
https://www.readbyqxmd.com/read/28109281/evaluation-of-a-program-to-strengthen-general-practice-care-for-patients-with-chronic-disease-in-germany
#15
Michel Wensing, Joachim Szecsenyi, Christian Stock, Petra Kaufmann Kolle, Gunter Laux
BACKGROUND: A program to strengthen general practice care for patients with chronic disease was offered in Germany. Enrollment was a free individual choice for both patients and physicians. This study aimed to examine the long-term impact of this program. METHODS: Two comparative evaluations were done, at 4 and 5 years (T1 and T2) after start of the program. In each year, patients in the program were compared with patients in usual care. Measures were based on routinely collected data and concerned 11 aspects of primary care and hospital care...
January 21, 2017: BMC Health Services Research
https://www.readbyqxmd.com/read/28109160/antibiotics-for-infection-prevention-after-excision-of-the-cervical-transformation-zone
#16
REVIEW
Chumnan Kietpeerakool, Bandit Chumworathayi, Jadsada Thinkhamrop, Butsakorn Ussahgij, Pisake Lumbiganon
BACKGROUND: Excision of the transformation zone of the cervix is the most commonly used approach to treat cervical precancerous lesions (cervical intraepithelial neoplasia (CIN)) to reduce the risk of developing cervical cancer. As the excision of the transformation zone leaves a raw area on the cervix, there is a risk of infection following the procedure. The incidence of infection after cold knife conization (CKC) is 36%, whereas the incidence for large loop excision of the transformation zone (LLETZ, also known as loop electrical excision procedure (LEEP)) is much lower (0...
January 21, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28109052/the-use-of-methadone-to-facilitate-opioid-weaning-in-pediatric-critical-care-patients-a-systematic-review-of-the-literature-and-meta-analysis
#17
REVIEW
Leslie A Dervan, Beryl Yaghmai, Robert Scott Watson, Fredric M Wolf
BACKGROUND: Continuous opioid infusion therapy is commonly utilized in the pediatric intensive care setting to treat pain and facilitate tolerance of invasive therapies. Transitioning to methadone is one common strategy for weaning from continuous opioid infusions, but in practice this transition can be challenging, and many children still experience iatrogenic withdrawal. AIM: We reviewed the literature to evaluate the best available evidence to guide methadone therapy in this setting, and to summarize associated adverse events...
January 20, 2017: Paediatric Anaesthesia
https://www.readbyqxmd.com/read/28109045/misoprostol-for-cervical-priming-prior-to-hysteroscopy-in-postmenopausal-and-premenopausal-nulliparous-women-a-multicentre-randomised-placebo-controlled-trial
#18
M L Tasma, M Louwerse, W J Hehenkamp, P M Geomini, M Y Bongers, S Veersema, P J van Kesteren, E Tromp, J A Huirne, G C Graziosi
OBJECTIVE: To evaluate the reduction of pain by Misoprostol compared to placebo prior to hysteroscopy in postmenopausal and premenopausal nulliparous women. DESIGN: Randomised multicentre double-blind placebo controlled trial. SETTING: Two Dutch teaching hospitals and one Dutch university medical centre. POPULATION: Postmenopausal and premenopausal nulliparous women undergoing office hysteroscopy. METHODS: Patients were randomised to receive either 400 mcg Misoprostol or placebo 12 and 24 hours before hysteroscopy...
January 21, 2017: BJOG: An International Journal of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/28109027/amplitude-integrated-electroencephalography-can-predict-neurodevelopmental-outcome-at-12-months-of-corrected-age-in-very-preterm-infants
#19
Elisabeth Ralser, Vera Neubauer, Ulrike Pupp-Peglow, Ursula Kiechl-Kohlendorfer, Elke Griesmaier
AIM: It is difficult to find diagnostic tools than can reliably predict neurodevelopmental outcomes in very preterm infants in clinical practice. This study evaluated whether amplitude-integrated electroencephalography predicted neurodevelopmental outcome in preterm infants when they reached 12 months of corrected age. METHODS: Between October 2007 and December 2013 we studied 232 preterm infants (51% male) at Innsbruck Medical University Hospital, Austria. Their mean birth weight was 1,264 grams and their mean gestational age was 29...
January 20, 2017: Acta Paediatrica
https://www.readbyqxmd.com/read/28108819/preemptive-treatment-with-xonrid%C3%A2-a-medical-device-to-reduce-radiation-induced-dermatitis-in-head-and-neck-cancer-patients-receiving-curative-treatment-a-pilot-study
#20
Nicola Alessandro Iacovelli, Simona Naimo, Francesca Bonfantini, Anna Cavallo, Paolo Bossi, Carlo Fallai, Emanuele Pignoli, Salvatore Alfieri, Cristiana Bergamini, Federica Favales, Ester Orlandi
PURPOSE: The purpose of this study was to investigate efficacy, safety and tolerability of Xonrid®, a new medical device, in preventing radiation dermatitis associated with head and neck cancer (HNC) radiotherapy (RT). METHODS: In this monocentric, prospective pilot study, adult consecutive HNC patients who were planned to receive curative RT with or without chemotherapy were enrolled. Patients were instructed to apply Xonrid® on the irradiated area during treatment continuing until 2 weeks after the completion of RT or the development of severe skin toxicity...
January 20, 2017: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
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