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Medication use evalution

Michal Bukowski, Karolina Hyz, Monika Janczak, Marcin Hydzik, Grzegorz Dubin, Benedykt Wladyka
The versatile roles of toxin-antitoxin (TA) systems in bacterial physiology and pathogenesis have been investigated for more than three decades. Diverse TA loci in Bacteria and Archaea have been identified in genome-wide studies. The advent of massive parallel sequencing has substantially expanded the number of known bacterial genomic sequences over the last 5 years. In staphylococci, this has translated into an impressive increase from a few tens to a several thousands of available genomes, which has allowed us for the re-evalution of prior conclusions...
October 18, 2017: Scientific Reports
Varun Vaidya, Nilesh Gangan, Anthony Comerota, Fedor Lurie
BACKGROUND: Nonembolic acute limb ischemia (ALI) is a condition characterized by a sudden decrease in limb perfusion and requires immediate interventions. There are multiple treatment options available including surgery, catheter-directed thrombolysis (CDT), endovascular procedures, and hybrid treatment (a combination of open and endovascular techniques). Randomized trials provide information only on clinical efficacy, but not on economic outcomes. The objective of the study was to perform the cost-effective analysis comparing different treatment alternatives of ALI...
February 2017: Annals of Vascular Surgery
Goran Mitrić, Andrew Udy, Hiran Bandeshe, Pierre Clement, Rob Boots
BACKGROUND: Atrial fibrillation is a common rhythm disturbance in the general medical-surgical intensive care unit. Amiodarone is a popular drug in this setting but evidence to inform clinical practice remains scarce. We aimed to identify whether variation in the clinical use of amiodarone was associated with recurrent atrial fibrillation. METHODS: This was a retrospective audit of 177 critically ill patients who developed new-onset atrial fibrillation after admission to a tertiary level medical-surgical trauma intensive care unit...
April 2, 2016: Critical Care: the Official Journal of the Critical Care Forum
Ingerid Skjei Knudtsen, Jørund Graadal Svestad, Erlend Peter Skaug Sande, Bernt Louni Rekstad, Jan Rødal, Wouter van Elmpt, Michel Öllers, Eli Olaug Hole, Eirik Malinen
Biologic image guided radiotherapy (RT) with escalated doses to tumour sub volumes challenges today's RT dose planning and delivery systems. In this phantom study, we verify the capability of a clinical dose planning and delivery system to deliver an 18F-FDG-PET based dose painted treatment plan to a lung tumour. Furthermore, we estimate the uncertainties of the dose painted treatment compared to conventional RT plans. An anthropomorphic thorax phantom of polystyrene and polyurethane was constructed based on CT images of a lung cancer patient...
March 21, 2016: Physics in Medicine and Biology
Marcin Bednarek, Marek Trybus, Witold Pokrowiecki, Piotr Guzik, Zdzisław Wiśniowski
UNLABELLED: The essence of Dupuytryen's contracture is progressive process of fibrous overgrow of the subfascial sturctures of hand volar's surface. This is the reason of impaired range of the finger movement's and subsequent limitations of their function. MATERIAL AND METHODS: The study group consist of 95 patients treated because of Dupuytryen contracture in the 2nd Chair of Surgery, Medical College of JagielIonian University between 2006-2011. The subjective evalution of increase of hand's function quality was based on DASH (Disability of the Arm, Shoulder and Hand) questionnaire...
2013: Przegla̧d Lekarski
Füsun Yıldız, Gülbin Bingöl Karakoç, Refika Ersu Hamutçu, Nazan Yardım, Banu Ekıncı, Arzu Yorgancıoğlu
INTRODUCTION: Although chronic respiratory disorders are important causes of morbidity and mortality, health care workers, patients and caretakers are not well informed about these disorders. Therefore these problems are underdiagnosed and undertreated; also preventive measures are not widely taken. Our aim was to evaluate the knowledge of asthma and chronic obstructive pulmonary disease (COPD) in Turkey. This study was designed and performed as a Global Alliance Against Respiratory Disorders (GARD) project...
2013: Tüberküloz Ve Toraks
B Shrestha, S Dhungel
Hypertension and Chronic kidney disease (CKD) are common in Nepal. Control of blood pressure (BP) in general hypertensive patients is poor. Evaluation of adequacy of BP control in CKD patients with hypertension is rare. All consecutive indoor patients (52) with CKD and hypertension, attending echo-lab of Nepal Medical College Teaching Hospital during prospective study of 3 years period from 16th April 2008 to 15th April 2011, were evaluted. Mean age was 45.3 +/- 16.7 years. Male female ratio was 8:5. Brahman and Chhetri (22, 42...
June 2012: Nepal Medical College Journal: NMCJ
C Ostgathe, G Lindena, N Heussen, K Knübben, F Elsner, L Radbruch
INTRODUCTION: The German Cancer Aid funded 12 regional projects which developed different models of palliative home care. The realization of the projects were concurrently monitored and evaluated. MATERIAL AND METHODS: The funded projects were asked to document all patients who were cared for beginning in January 2009 using HOPE (Hospice and palliative survey), MIDOS (Minimal documentation system for palliative patients) and the Barthel index. Documentation was mandatory at the beginning and the end of care as well as when patients changed settings, for example when patients were transferred from a palliative care unit to a palliative home care service...
December 2011: Der Schmerz
Alessandro Fasciolo, Claudio Baldini
AIM: Subarachnoid anaesthesia has been demonstrated to be safe and effective in elderly patients. Isobaric Ropivacaine 0.5% has been recently introduced for subarachnoid anaesthesia: aim of our trial is to compare this drug with 0.5 Levobupivacaine in elderly patients scheduled for endoscopic urological surgery. METHODS: Premedication: Atropine 0.5 mg + Fenotiazine 50 mg im. Lumbar intrathecal anaesthesia, Group L (n=25) receiving Levobupivacaine 15 mg, Group R (n=25) receiving Ropivacaine 18...
January 2011: Urologia
Isabel Spriet, Wouter Meersseman, Alexander Wilmer, Geert Meyfroidt, Minne Casteels, Ludo Willems
OBJECTIVE: Sepsis remains a major cause of mortality in ICU patients, despite advances in therapy. Drotrecogin alpha (Drot AA), a recombinant human activated protein C with anti-inflammatory and anticoagulant properties, has proven to be successful in patients with at least one organ failure. Our goal was to evaluate the data in patients with sepsis and at least two organ dysfunctions in a large university hospital in Belgium. SETTING: The study was conducted at the medical and surgical intensive care units of the 1850-bed university hospital of Leuven, Belgium...
October 2006: Pharmacy World & Science: PWS
Trevor D B Thompson, Marjorie Weiss
BACKGROUND: Research in homeopathy has traditionally addressed itself to defining the effectiveness of homeopathic potencies in comparison to placebo medication. There is now increasing awareness that the homeopathic consultation is in itself a therapeutic intervention working independently or synergistically with the prescribed remedy. Our objective was to identify and evalute potential "active ingredients" of the homeopathic approach as a whole, in a prospective formal case series, which draws on actual consultation data, and is based on the MRC framework for the evaluation of complex interventions...
November 13, 2006: BMC Complementary and Alternative Medicine
A Rózga, A J Kurnatowska, G Raczyńsak-Witońska, G Loga
We have evaluated the activity of acid aspartic protease in 195 strains of Candida isolated from the oral cavity of three groups of patients. The first group comprised patients with cancer of the larynx qualified for surgery, the second- patients with neoplastic disease ( Hodgkin s disease, lymphoma, acute granulocytic leukaemia, lymphatic leukaemia, lung cancer, multiple myeloma, stomach cancer, breast cancer) who were not treated, the third group- patients with neoplastic diseases treated by chemotherapy...
2001: Wiadomości Parazytologiczne
Jessica Greene, Michael J Yedidia et al.
Effective treatment of chronic illness requires active engagement of patients in managing their own conditions. This research explores the influence of provider support for self-management on patients' performance of self-care activities, a widely presumed but under-studied relationship, particularly among underserved populations. We surveyed an ethnically diverse, primarily low-income sample of 956 patients (or parents of pediatric patients) with diabetes or asthma in 17 outpatient teaching settings across the country...
November 2005: Journal of Health Care for the Poor and Underserved
V Pesáková, K Smetana, K Balík, J Hruska, M Petrtýl, H Hulejová, M Adam
We studied the biocompatibility of the carbon composites and polyethylene materials with and without collagen or collagen and proteoglycan cover. We used the in vitro technology to study the adhesion of model cells evalution, their metabolic activity and the production of TNF-alpha as a cytokine model. Under in vivo condition, the biocompatibility of tested polymers were studied in the implantation experiment, subcutaneously in the interscapular region in the laboratory rat. We have found in the in vitro assay favorable proliferation and the smallest production of pro-inflammatory TNF-alpha cytokine in cells adherent to the hydrophobic polyethylene material coated with biological macromolecules...
June 2003: Journal of Materials Science. Materials in Medicine
L Knebel, G Ludwig
Recurrent urinary tract infections, vesicoureteral reflux and enuresis in children want a detailed urologic evalution which often makes - in addition to obvious urinealysis, urine culture, excretory urography and voiding cystourethrography-extended diagnostics necessary including an urethral calibration to definitely exclude a distal urethral stenosis, and a cystoscopy under general anesthesia in order to reveal abnormalities of shape and placement of the ureteral orifice (e.g. lateral placement, "stadium", "horseshoe" or "golf-hole" shape)...
April 24, 1980: Fortschritte der Medizin
R S Ledley, G Di Chiro, A J Luessenhop, H L Twigg
The ACTA-Scanner has virtually unlimited potential in the evalution of any part of the body. The usefulness of the technique has already been shown in the appraisal of pathologies of the brain and cerebrospinal fluid cavities. The orbits and the eyeballs, the facial sinuses, and skull base lesions have also been elucidated. Tumors of the larynx, pharynx, thyroid, and parathyroid; lymphomas; and pathology of the spine and spinal cord are well within the reach of this new diagnostic methodology. Lung pathologies, such as emphysema, pneumonias, neoplasms, infarctions, pleural effusions and granulomatous diseases, and mediastinal pathology represent a challenging complex of lesions to be appraised by ACTA-scanning...
October 18, 1974: Science
W I Wolfe, H Shinya
The problem of the malignant potential of neoplastic colonic polyps is being, in large measure, resolved by newly derived techniques. Now most polyps may be removed endoscopically using the fiberoptic colonoscope. The largest world experience is at the Beth Israel Medical Center in New York, where over 2000 polyps have been endoscopically removed without a single death and with but one complication requiring operative intervention. Laparotomy is now reserved for polyps not suitable for endoscopic resection or where a question of residual cancer exists...
August 1975: Cancer
B Vrhovac
Placebo can be defined as "a therapeutic effect, drug or non-drug, or a part of it which, in the condition being treated, objectively does not have any specific pharmacodynamic action." Even today when powerful drugs are available placebo is important and present in therapy. Effective therapeutic agents are also sometimes used as placebo, mostly inadvertently. In clinical pharmacological investigations placebos are used deliberately to discriminate the pharmacodynamic action of drugs from psychic and other factors which can influence the objective of the drug evalution...
April 1977: International Journal of Clinical Pharmacology and Biopharmacy
V Vignaendra, J Walsh, S Burrows
The clinical application of prolonged monitoring by the combined EEG and videotape recording of patients was evaluted. This test was found to be useful in diagnosing epileptic seizures in patients in whom both the history and diurnal EEG studies were unhelpful, and it assisted with the accurate classification of seizure types. It enabled seizure focus lateralisation in medically intractable epileptic who were being evaluated for surgery, and it also provided an objective estimate of minor seizure frequency...
1979: Clinical and Experimental Neurology
R A Chalmers, H B Valman, M M Liberman
We evaluted measurement of urinary 4-hydroxyphenyl acetic acid as a potential screening method for small-bowel disease and bacterial overgrowth syndromes in 360 unselected acutely ill infants and children. Control data were obtained on 120 healthy children, ages 1.5 to 15 years, from a general medical practice, 48 healthy infants, ages one to five years, from local day nurseries, and 150 healthy babies, ages less than one to eight days. Comparative data were from 300 acutely ill hospitalized babies and children, ranging in age from less than one day to 15 years and without clinical evidence for small-bowel disease and bacterial overgrowth syndrome...
October 1979: Clinical Chemistry
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