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hypothyroidism subclinical treatment

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https://www.readbyqxmd.com/read/28059636/the-effects-of-adequate-iodine-supply-on-the-incidence-of-iodine-induced-thyroid-disorders-in-slovenia
#1
Vid Bajuk, Katja Zaletel, Edvard Pirnat, Sergej Hojker, Simona Gaberšček
BACKGROUND: We aimed to establish the changes in the incidence and characteristics of iodine-induced hyperthyroidism (II-Hyper) and iodine-induced hypothyroidism (II-Hypo) in the two-year period before and the ten-year period after the increase in mandatory salt iodization from the previous 10 mg of potassium iodide to 25 mg per kg in 1999. Furthermore, we aimed at determining the duration of treatment in II-Hyper patients, since no data regarding severity and treatment of II-Hyper with respect to iodine supply are available...
January 6, 2017: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/28038798/cardiovascular-risk-in-chronic-autoimmune-thyroiditis-and-subclinical-hypothyroidism-patients-a-cluster-analysis
#2
Giovanni Carbotta, Francesco Tartaglia, Alessandro Giuliani, Sabino Carbotta, Luciana Tromba, Ilaria Jacomelli, Livia De Anna, Angela Fumarola
BACKGROUND: Subclinical hypothyroidism (SCH) and chronic autoimmune thyroiditis (CAT) are linked to an increased risk of atherosclerosis and coronary heart disease (CHD). The aim of this study was to look for positive markers of CHD and correlations with thyroid blood tests in patients with SCH or CAT, but no symptoms of CHD, so as to identify CHD risk conditions that otherwise would likely be missed. METHODS: We measured a series of thyroid, clinical-metabolic and cardiovascular parameters in 30 consecutive endocrinology patients enrolled in our ambulatory endocrinological referral center of "Sapienza" University of Rome...
December 21, 2016: International Journal of Cardiology
https://www.readbyqxmd.com/read/28029020/clinical-update-in-aspects-of-the-management-of-autoimmune-thyroid-diseases
#3
REVIEW
Duncan J Topliss
Aspects of autoimmune thyroid disease updated in this review include: immunoglobulin G4 (IgG4)-related thyroid disease (Riedel's thyroiditis, fibrosing variant of Hashimoto's thyroiditis, IgG4-related Hashimoto's thyroiditis, and Graves' disease with elevated IgG4 levels); recent epidemiological studies from China and Denmark indicating that excess iodine increases the incidence of Hashimoto's thyroiditis and hypothyroidism; immunomodulatory agents (ipilimumab, pembrolizumab, nivolumab) activate immune response by inhibiting T-cell surface receptors which down-regulate immune response, i...
December 2016: Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28028828/thyroid-abnormalities-following-the-use-of-ctla-4-and-pd-1-inhibitors-in-the-treatment-of-melanoma
#4
D L Morganstein, Z Lai, L Spain, S Diem, D Levine, C Mace, M Gore, J Larkin
CONTEXT: Checkpoint inhibitors are emerging as important cancer therapies, but are associated with a high rate of immune side effects, including endocrinopathy. OBJECTIVE: To determine the burden of thyroid dysfunction in patients with melanoma treated with immune checkpoint inhibitors and describe the clinical course. DESIGN AND PATIENTS: Consecutive patients with melanoma treated with either Ipilimumab, Nivolumab, Pembrolizumab or the combination of Ipilimumab and Nivolumab were identified...
December 27, 2016: Clinical Endocrinology
https://www.readbyqxmd.com/read/27886341/clinical-efficacy-of-therapeutic-intervention-for-subclinical-hypothyroidism-during-pregnancy
#5
R Ju, L Lin, Y Long, J Zhang, J Huang
This study explored the effects of levothyroxine (L-T4) replacement therapy on pregnancy outcomes in patients with subclinical hypothyroidism (SCH). We analyzed the effects on pregnancy outcomes with respect to gestational week when the desired thyroid-stimulating hormone (TSH) level was reached as well as the length of time required to reach the target level during L-T4 treatment. This study enrolled 457 patients diagnosed with SCH upon initial thyroid function screening. Subjects were assigned to the treatment group (N = 184), and the control group (N = 273)...
November 21, 2016: Genetics and Molecular Research: GMR
https://www.readbyqxmd.com/read/27879326/effects-of-levothyroxine-treatment-on-pregnancy-outcomes-in-pregnant-women-with-autoimmune-thyroid-disease
#6
Sima Nazarpour, Fahimeh Ramezani Tehrani, Masoumeh Simbar, Maryam Tohidi, Hamid Alavi Majd, Fereidoun Azizi
BACKGROUND: Despite some studies indicating that thyroid antibody positivity during pregnancy has been associated with adverse pregnancy outcomes, evidence regarding the effects of levothyroxine (LT4) treatment of euthyroid/subclinical hypothyroid pregnant women with autoimmune thyroid disease on pregnancy outcome is limited. We aimed to assess whether pregnant women with autoimmune thyroid disease, but without overt thyroid dysfunction are affected by higher rates of adverse pregnancy outcomes...
February 2017: European Journal of Endocrinology
https://www.readbyqxmd.com/read/27867875/coronary-artery-calcium-scoring-is-a-better-predictor-of-cardiac-risk-in-subclinical-hypothyroidism-patients-with-low-risk-framingham-score
#7
Rajesh Verma, Ashish Verma, Piyush Gupta, N K Agrawal
CONTEXT: Overt hypothyroidism accelerates the cardiovascular disease. Subclinical hypothyroidism (SCH), being considered as a preclinical state, impacts on cardiovascular status is not clear. AIMS: This study was aimed at assessing cardiac risk stratification by Framingham risk scoring (FRS) and coronary coronary artery calcium score (CACS) by noncontrast cardiac computed tomography in SCH. STUDY DESIGN: Observational study. SUBJECTS AND METHODS: We enrolled thirty treatment-naive SCH patients (aged 30-60 years with no serious concurrent medical conditions), thirty euthyroid (age, sex, and body mass index-matched) controls, and ten healthy controls...
November 2016: Indian Journal of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/27864708/thyroid-dysfunction-and-kidney-disease-an-update
#8
REVIEW
Pedro Iglesias, María Auxiliadora Bajo, Rafael Selgas, Juan José Díez
Thyroid hormones influence renal development, kidney hemodynamics, glomerular filtration rate and sodium and water homeostasis. Hypothyroidism and hyperthyroidism affect renal function by direct renal effects as well as systemic hemodynamic, metabolic and cardiovascular effects. Hypothyroidism has been associated with increased serum creatinine and decreased glomerular filtration rate. The reverse effects have been reported in thyrotoxicosis. Most of renal manifestations of thyroid dysfunction are reversible with treatment...
November 18, 2016: Reviews in Endocrine & Metabolic Disorders
https://www.readbyqxmd.com/read/27843806/a-2016-italian-survey-about-the-clinical-use-of-selenium-in-thyroid-disease
#9
Roberto Negro, Roberto Attanasio, Franco Grimaldi, Claudio Marcocci, Rinaldo Guglielmi, Enrico Papini
BACKGROUND: Selenium (Se) is a trace element that plays key roles in thyroid physiology. Se deficiency is associated with increased risk of thyroid disease. Some evidence suggests that Se supplementation may be beneficial in autoimmune thyroid disease (either hypo- or hyperthyroidism). OBJECTIVES: We sought to examine the use of Se in daily clinical practice among Italian endocrinologists. METHODS: Members of the Associazione Medici Endocrinologi (AME) were invited to participate in a web-based survey investigating the use of Se in different clinical conditions...
September 2016: European Thyroid Journal
https://www.readbyqxmd.com/read/27811932/thyroid-hormones-and-cardiovascular-disease
#10
REVIEW
Avais Jabbar, Alessandro Pingitore, Simon H S Pearce, Azfar Zaman, Giorgio Iervasi, Salman Razvi
Myocardial and vascular endothelial tissues have receptors for thyroid hormones and are sensitive to changes in the concentrations of circulating thyroid hormones. The importance of thyroid hormones in maintaining cardiovascular homeostasis can be deduced from clinical and experimental data showing that even subtle changes in thyroid hormone concentrations - such as those observed in subclinical hypothyroidism or hyperthyroidism, and low triiodothyronine syndrome - adversely influence the cardiovascular system...
January 2017: Nature Reviews. Cardiology
https://www.readbyqxmd.com/read/27790421/a-study-to-assess-the-validity-of-estimation-of-serum-ostase-level-in-hyperthyroid-and-hypothyroid-cases
#11
Polina Boruah, Arup Jyoti Baruah, Ranendra Hajong, Chandan Kumar Nath, Bhupen Barman, Happy Chutia, Kalyan Sarma
INTRODUCTION: One of the more specific assessments of the metabolic status of bone in normal and in disease conditions is the measurement of bone specific alkaline phosphatase or ostase. The measurement of serum ostase has several advantages over the measurements of other bone parameter. Because of its relatively long half-life, in-vivo (1 to 3days), it is relatively unaffected by diurnal variation. AIM: To find the correlation of serum ostase level in hyper and hypothyroid cases and also to study the validity of routine estimation of serum ostase in hyper and hypothyroid cases so as to monitor the base level bone health on presentation...
September 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/27779276/the-debate-on-treating-subclinical-hypothyroidism
#12
Eng Loon Tng
Subclinical hypothyroidism (SCH) represents a mild or compensated form of primary hypothyroidism. The diagnosis of SCH is controversial, as its symptoms are non-specific and its biochemical diagnosis is arbitrary. The treatment of SCH was examined among non-pregnant adults, pregnant adults and children. In non-pregnant adults, treatment of SCH may prevent its progression to overt hypothyroidism, reduce the occurrence of coronary heart disease, and improve neuropsychiatric and musculoskeletal symptoms associated with hypothyroidism...
October 2016: Singapore Medical Journal
https://www.readbyqxmd.com/read/27750362/subclinical-hypothyroidism-impact-on-fertility-obstetric-and-neonatal-outcomes
#13
Rebecca S Usadi, Kathryn S Merriam
The incidence of subclinical hypothyroidism (SCH) in pregnancy was classically thought to be low; however, with new definition of normal TSH range in pregnancy, there has been an increase in the percentage of women who meet classification for SCH. The diagnosis of SCH is important not only for monitoring for maternal conversion to overt hypothyroidism, but also for identifying obstetric and neonatal outcomes related to SCH. Although there have been proven associations between maternal overt hypothyroidism and adverse obstetric and neonatal outcomes, there has been conflicting data on the correlation between SCH and these outcomes...
November 2016: Seminars in Reproductive Medicine
https://www.readbyqxmd.com/read/27741550/the-impact-and-management-of-subclinical-hypothyroidism-for-improving-reproductive-outcomes-such-as-fertility-and-miscarriage
#14
Aimee Seungdamrong
Subclinical hypothyroidism has been found to be associated with adverse reproductive outcomes, such as infertility, miscarriage, preterm birth, and complications of pregnancy. Multiple studies have investigated the relationships between thyroid function, thyroid antibodies, fertility, and pregnancy. Thyroid autoimmunity is the most common cause of hypothyroidism in iodine-sufficient locations. Thyroid antibodies have been associated with adverse reproductive outcomes such as miscarriage and infertility. Debate exists regarding the method of identification of thyroid dysfunction in pregnancy, which can be conducted by targeted screening or by universal screening...
November 2016: Seminars in Reproductive Medicine
https://www.readbyqxmd.com/read/27741547/overview-of-hypothyroidism-in-pregnancy
#15
Jeffrey M Kroopnick, Caroline S Kim
Overt hypothyroidism in pregnancy, defined as an elevated serum thyroid-stimulating hormone (TSH) and reduced serum free thyroxine or a TSH >10 mIU/L, is known to have adverse effects on pregnancy. Subclinical hypothyroidism is typically defined as an elevated TSH and normal FT4 levels. There remains much controversy on the benefit of starting levothyroxine for mothers diagnosed with subclinical hypothyroidism. Recent studies are redefining the normal range for TSH in pregnancy, and the data on whether treatment of subclinical hypothyroidism improves outcomes for the mother and fetus are unclear...
November 2016: Seminars in Reproductive Medicine
https://www.readbyqxmd.com/read/27734699/-thyroid-hormones-and-cardiovascular-system
#16
Zdeňka Límanová, Jan Jiskra
Cardiovascular system is essentially affected by thyroid hormones by way of their genomic and non-genomic effects. Untreated overt thyroid dysfunction is associated with higher cardiovascular risk. Although it has been studied more than 3 decades, in subclinical thyroid dysfunction the negative effect on cardiovascular system is much more controversial. Large meta-analyses within last 10 years have shown that subclinical hyperthyroidism is associated with higher cardiovascular risk than subclinical hypothyroidism...
2016: Vnitr̆ní Lékar̆ství
https://www.readbyqxmd.com/read/27730076/high-atherogenic-index-of-plasma-in-subclinical-hypothyroidism-implications-in-assessment-of-cardiovascular-disease-risk
#17
Stephen R James, Lopamudra Ray, Kandasamy Ravichandran, Sunil Kumar Nanda
BACKGROUND: A controversy exists regarding the association between subclinical hypothyroidism (SH) and dyslipidemia. Moreover, studies on lipid ratios and atherogenic index of plasma (AIP) in SH are rare, particularly in the Indian scenario. AIM: This study aimed to investigate abnormalities in conventional lipid profile, lipid ratios, and AIP in SH and attempted to correlate thyroid stimulating hormone (TSH) and AIP in SH. MATERIALS AND METHODS: In this retrospective analysis of patient records of SH subjects and euthyroid subjects, age, free triiodothyronine, free thyroxine, TSH, total cholesterol, triglycerides, high-density lipoprotein-cholesterol (HDL-C), low-density lipoprotein-cholesterol, lipid ratios, and AIP were compared between the two groups...
September 2016: Indian Journal of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/27692273/abnormal-thyroid-hormones-and-non-thyroidal-illness-syndrome-in-obstructive-sleep-apnea-and-effects-of-cpap-treatment
#18
Albino Petrone, Flaminio Mormile, Giacomo Bruni, Michela Quartieri, Maria R Bonsignore, Oreste Marrone
OBJECTIVE: In obstructive sleep apnea (OSA), while both hypothyroidism and hyperthyroidism have been studied, the occurrence of non-thyroidal illness syndrome (NTIS) (normal thyroid stimulating hormone [TSH] with low triiodotironine) has not been investigated. We explored the occurrence of NTIS in patients with moderate to severe OSA and its relationship to the severity of nocturnal respiratory disorders. We also studied the occurrence of subclinical hypothyroidism (SH, ie, high TSH with normal thyroxine) in OSA and changes in circulating TSH, free triiodotironine (fT3) and free thyroxine (fT4) after CPAP treatment...
July 2016: Sleep Medicine
https://www.readbyqxmd.com/read/27686165/thyroid-function-and-risk-of-type-2-diabetes-a-population-based-prospective-cohort-study
#19
Layal Chaker, Symen Ligthart, Tim I M Korevaar, Albert Hofman, Oscar H Franco, Robin P Peeters, Abbas Dehghan
BACKGROUND: The association of thyroid function with risk of type 2 diabetes remains elusive. We aimed to investigate the association of thyroid function with incident diabetes and progression from prediabetes to diabetes in a population-based prospective cohort study. METHODS: We included 8452 participants (mean age 65 years) with thyroid function measurement, defined by thyroid-stimulating hormone (TSH) and free thyroxine (FT4), and longitudinal assessment of diabetes incidence...
September 30, 2016: BMC Medicine
https://www.readbyqxmd.com/read/27673426/respiratory-manifestations-of-hypothyroidism-a-systematic-review
#20
Jesper Roed Sorensen, Kristian Hillert Winther, Steen Joop Bonnema, Christian Godballe, Laszlo Hegedüs
BACKGROUND: Hypothyroidism has been associated with increased pulmonary morbidity and overall mortality. A systematic review was conducted to identify the prevalence and underlying mechanisms of respiratory problems among patients with thyroid insufficiency. METHODS: PubMed and EMBASE databases were searched for relevant literature from January 1950 through January 2015 with the following study eligibility criteria: English-language publications; adult subclinical or overt hypothyroid patients; intervention, observational, or retrospective studies; and respiratory manifestations...
November 2016: Thyroid: Official Journal of the American Thyroid Association
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