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https://www.readbyqxmd.com/read/28329380/subclinical-thyroid-dysfunction-and-cardiovascular-diseases-2016-update
#1
Carmen Floriani, Baris Gencer, Tinh-Hai Collet, Nicolas Rodondi
Subclinical thyroid dysfunction comprises subclinical hypothyroidism (SHypo), defined as elevated thyroid-stimulating hormone (TSH) by normal free thyroxine (FT4), and subclinical hyperthyroidism (SHyper) with decreased or undetectable TSH and normal FT4. Up to 10% of the elderly have SHypo, which is usually asymptomatic. Individual participant data (IPD) analyses of prospective cohort studies from the international Thyroid Studies Collaboration show that SHypo is associated with increased coronary heart disease (CHD) mortality [hazard ratio (HR) 1,58 for TSH ≥ 10 mIU/L, 95% CI 1...
February 27, 2017: European Heart Journal
https://www.readbyqxmd.com/read/28327186/clinical-behavioural-and-pharmacogenomic-factors-influencing-the-response-to-levothyroxine-therapy-in-patients-with-primary-hypothyroidism-protocol-for-a-systematic-review
#2
Rosie Dew, Onyebuchi Okosieme, Colin Dayan, Vinay Eligar, Ishrat Khan, Salman Razvi, Simon Pearce, Scott Wilkes
BACKGROUND: Suboptimal thyroid hormone therapy including under-replacement and over-replacement is common amongst patients with hypothyroidism. This is a significant health concern as affected patients are at risk of adverse cardiovascular or metabolic consequences. Despite a growing body of evidence on the effects of various factors on thyroid hormone replacement, a systematic appraisal of the evidence is lacking. This review aims to appraise and quantify the extent to which clinical, behavioural and pharmacogenomic factors affect levothyroxine therapy in patients with primary hypothyroidism...
March 21, 2017: Systematic Reviews
https://www.readbyqxmd.com/read/28325221/is-metabolic-dysregulation-associated-with-antidepressant-response-in-depressed-women-in-climacteric-treated-with-individualized-homeopathic-medicines-or-fluoxetine-the-homdep-menop-study
#3
Emma Del Carmen Macías-Cortés, Lidia Llanes-González, Leopoldo Aguilar-Faisal, Juan Asbun-Bojalil
BACKGROUND: Climacteric is associated with both depression and metabolic dysregulation. Scarce evidence suggests that metabolic dysregulation may predict poor response to conventional antidepressants. Response to depression treatment has not been studied in homeopathic medicine. The aim of this study was to investigate the prevalence of metabolic disorders in depressed climacteric women treated with homeopathic medicines, fluoxetine or placebo, and if these alterations have any association with response to depression treatment...
February 2017: Homeopathy: the Journal of the Faculty of Homeopathy
https://www.readbyqxmd.com/read/28323629/effects-of-levothyroxine-on-pregnancy-outcomes-in-women-with-thyroid-dysfunction-a-meta-analysis-of-randomized-controlled-trials
#4
Jia Li, Jie Shen, Lan Qin
Context • Subclinical hypothyroidism (SCH) in pregnancy can be associated with increased complications in pregnant women and neurocognitive deficits in fetuses. Two recently published meta-analyses investigated the effects of levothyroxine (LT4) supplementation on pregnancy outcomes but did not report adverse complications and neonatal outcomes. Objectives • The study intended to assess the effects of LT4 supplementation in the treatment of pregnant women with thyroid dysfunction. Design • The research team performed a meta-analysis of randomized controlled trials (RCTs) published in PubMed, Embase, Web of Science, Chinese BioMedical Literature Service System, and China National Knowledge Infrastructure databases...
March 2017: Alternative Therapies in Health and Medicine
https://www.readbyqxmd.com/read/28315587/the-effect-of-l-thyroxine-treatment-on-sexual-function-and-depressive-symptoms-in-men-with-autoimmune-hypothyroidism
#5
Robert Krysiak, Witold Szkróbka, Bogusław Okopień
BACKGROUND: Thyroid autoimmunity and mild hypothyroidism in women seem to be associated with sexual dysfunction and depressive symptoms. Data concerning similar associations in men are limited. The aim of this study was to investigate sexual functioning and depressive symptoms in men with autoimmune hypothyroidism. METHODS: The study population consisted of three groups: men with autoimmune overt hypothyroidism (group A), men with autoimmune subclinical hypothyroidism (group B) and healthy euthyroid males without thyroid autoimmunity (group C)...
January 17, 2017: Pharmacological Reports: PR
https://www.readbyqxmd.com/read/28302959/natural-history-of-mild-subclinical-hypothyroidism-in-a-middle-aged-and-elderly-chinese-population-a-prospective-study
#6
Xiang Li, Donghu Zhen, Meng Zhao, Lu Liu, Qingbo Guan, Haiqing Zhang, Shujian Ge, Xulei Tang, Ling Gao
Subclinical hypothyroidism (SCH) has a high global prevalence. Most SCH patients have mild cases (thyrotropin ≤10 mIU/L). Treatment recommendations for mild SCH are controversial, which raises concerns about the natural history of mild SCH. We aimed to clarify the natural history of mild SCH. This is a prospective population-based study. We measured thyroid function in 11,000 participants in the REACTION study and followed 505 newly diagnosed mild SCH patients aged 40-years or older between 2011 and 2014...
March 7, 2017: Endocrine Journal
https://www.readbyqxmd.com/read/28293260/treatment-with-myo-inositol-and-selenium-ensures-euthyroidism-in-patients-with-autoimmune-thyroiditis
#7
Maurizio Nordio, Sabrina Basciani
Clinical evidences have highlighted the efficacy of myo-inositol and selenium in the treatment of autoimmune thyroiditis. Aim of this study was to further analyze the role of myo-inositol plus selenium (Myo-Ins-Se) in restoring a normal thyroid function of Hashimoto's patients with subclinical hypothyroidism. Eighty-six patients with Hashimoto's thyroiditis having thyroid-stimulating hormone (TSH) levels between 3 and 6 mIU/L, elevated serum antithyroid peroxidase (TPOAb) and/or antithyroglobulin (TgAb), and normal free thyroxine (fT4) and free triiodothyronine (fT3) levels were enrolled in the study: one hyperthyroid subject with TSH about 0...
2017: International Journal of Endocrinology
https://www.readbyqxmd.com/read/28261292/epicardial-fat-thickness-and-oxidative-stress-parameters-in-patients-with-subclinical-hypothyroidism
#8
Ali Aydogdu, Emel Yigit Karakas, Emre Erkus, İbrahim Halil Altıparmak, Emin Savık, Turgay Ulas, Tevfik Sabuncu
INTRODUCTION: Thyroid disorders are known to be a risk factor for cardiovascular diseases. Epicardial fat thickness (EFT) and oxidative stress are also believed to be major risk factors for cardiovascular events. The aim of this study was to evaluate the possible relationship between oxidative stress parameters and EFT in patients with subclinical hypothyroidism (SCH). MATERIAL AND METHODS: A total of 60 individuals (30 patients with SCH and 30 healthy controls) were recruited for the study...
March 1, 2017: Archives of Medical Science: AMS
https://www.readbyqxmd.com/read/28249936/subclinical-hypothyroidism-to-treat-or-not-to-treat-a-systematic-review-with-meta-analysis-on-lipid-profile
#9
Isabel Abreu, Eva Lau, Bernardo Sousa-Pinto, Davide Carvalho
Previous studies suggested that subclinical hypothyroidism has a detrimental effect on cardiovascular risk factors, and that its effective treatment may have a beneficial impact on overall health. The main purpose of this review and meta-analysis was to assess whether subclinical hypothyroidism treatment is of clinical relevance, based on cardiovascular risk parameters correction. A systemic research of the literature using MEDLINE tool was performed to identify the relevant studies. Only placebo-controlled randomized control trials were included...
March 1, 2017: Endocrine Connections
https://www.readbyqxmd.com/read/28249913/alteration-of-hemostatic-parameters-in-patients-with-different-levels-of-subclinical-hypothyroidism-and-the-effect-of-l-thyroxine-treatment
#10
Fang Gao, Guangya Wang, Jinxiu Xu
Subclinical hypothyroidism (SH) is associated with hypercoagulability and hypofibrinolysis. The objective of this study was to assess the effect of L-thyroxine (L-T4) treatment and to evaluate changes in the hemostatic abnormalities of patients with varying severities of SH. We measured tissue plasminogen activator (t-PA), plasminogen activator inhibitor-1 (PAI-1), D-dimer (DDI), fibrinogen (FIB), platelet counts (PLT), mean platelet volume (MPV), platelet distribution width (PDW), activated partial thromboplastin time (APTT), and prothrombin time (PT) in 149 female subjects...
January 2017: Annals of Clinical and Laboratory Science
https://www.readbyqxmd.com/read/28249134/treatment-of-subclinical-hypothyroidism-or-hypothyroxinemia-in-pregnancy
#11
RANDOMIZED CONTROLLED TRIAL
Brian M Casey, Elizabeth A Thom, Alan M Peaceman, Michael W Varner, Yoram Sorokin, Deborah G Hirtz, Uma M Reddy, Ronald J Wapner, John M Thorp, George Saade, Alan T N Tita, Dwight J Rouse, Baha Sibai, Jay D Iams, Brian M Mercer, Jorge Tolosa, Steve N Caritis, J Peter VanDorsten
Background Subclinical thyroid disease during pregnancy may be associated with adverse outcomes, including a lower-than-normal IQ in offspring. It is unknown whether levothyroxine treatment of women who are identified as having subclinical hypothyroidism or hypothyroxinemia during pregnancy improves cognitive function in their children. Methods We screened women with a singleton pregnancy before 20 weeks of gestation for subclinical hypothyroidism, defined as a thyrotropin level of 4.00 mU or more per liter and a normal free thyroxine (T4) level (0...
March 2, 2017: New England Journal of Medicine
https://www.readbyqxmd.com/read/28176633/hypothyroidism-and-nephrotic-syndrome-why-when-and-how-to-treat
#12
Francesca Di Mario, Riccardo Pofi, Antonietta Gigante, Laura Rivoli, Edoardo Rosato, Andrea Maria Isidori, Rosario Cianci, Biagio Barbano
Hypothyroidism, characterised by low/normal free thyroxine (FT4) and free tri-iodothyronine (FT3) with elevated thyroid-stimulating hormone (TSH), is a well-known complication of nephrotic syndrome (NS). This is a common feature of primary and secondary glomerular diseases and comprises loss of protein in the urine and increased urinary excretion of thyroid hormones and thyroxine-binding globulin. With a normal thyroid reserve, this scenario is associated with the development of subclinical hypothyroidism, with a slight increase in TSH and normal free fractions...
February 7, 2017: Current Vascular Pharmacology
https://www.readbyqxmd.com/read/28158982/study-protocol-thyroid-hormone-replacement-for-untreated-older-adults-with-subclinical-hypothyroidism-a-randomised-placebo-controlled-trial-trust
#13
RANDOMIZED CONTROLLED TRIAL
David J Stott, Jacobijn Gussekloo, Patricia M Kearney, Nicolas Rodondi, Rudi G J Westendorp, Simon Mooijaart, Sharon Kean, Terence J Quinn, Naveed Sattar, Kirsty Hendry, Robert Du Puy, Wendy P J Den Elzen, Rosalinde K E Poortvliet, Jan W A Smit, J Wouter Jukema, Olaf M Dekkers, Manuel Blum, Tinh-Hai Collet, Vera McCarthy, Caroline Hurley, Stephen Byrne, John Browne, Torquil Watt, Douglas Bauer, Ian Ford
BACKGROUND: Subclinical hypothyroidism (SCH) is a common condition in elderly people, defined as elevated serum thyroid-stimulating hormone (TSH) with normal circulating free thyroxine (fT4). Evidence is lacking about the effect of thyroid hormone treatment. We describe the protocol of a large randomised controlled trial (RCT) of Levothyroxine treatment for SCH. METHODS: Participants are community-dwelling subjects aged ≥65 years with SCH, diagnosed by elevated TSH levels (≥4...
February 3, 2017: BMC Endocrine Disorders
https://www.readbyqxmd.com/read/28158908/efficacy-of-low-dose-2-millicurie-versus-standard-dose-4-millicurie-radioiodine-treatment-for-cats-with-mild-to-moderate-hyperthyroidism
#14
J M Lucy, M E Peterson, J F Randolph, P V Scrivani, M Rishniw, D L Davignon, M S Thompson, J M Scarlett
BACKGROUND: Radioiodine ((131) I) is effective treatment for hyperthyroidism in cats, but optimal dose to restore euthyroidism without inducing hypothyroidism is unclear. Treatment-induced hypothyroidism can lead to azotemia and reduced duration of survival. OBJECTIVE: To compare efficacy and short-term outcomes of low-dose (131) I versus higher, standard-dose (131) I as treatment for hyperthyroidism. ANIMALS: A total of 189 client-owned cats undergoing (131) I treatment for mild-to-moderate hyperthyroidism (serum T4 ≥ 4...
March 2017: Journal of Veterinary Internal Medicine
https://www.readbyqxmd.com/read/28153744/thyroid-stimulating-hormone-tsh-%C3%A2-2-5mu-l-in-early-pregnancy-prevalence-and-subsequent-outcomes
#15
David M Carty, Flora Doogan, Paul Welsh, Anna F Dominiczak, Christian Delles
OBJECTIVE: There remains controversy over how women with abnormal thyroid function tests in pregnancy should be classified. In this study we assessed the proportion of women with thyroid stimulating hormone (TSH)≥2.5mU/l in a large obstetric cohort, and examined how many have gone on to develop thyroid disease in the years since their pregnancy. STUDY DESIGN: 4643 women were recruited and samples taken in early pregnancy between 2007 and 2010. Thyroid function tests were analysed in 2014; in women with raised TSH computerised health records and prescription databases were used to identify thyroid disease detected since pregnancy...
January 25, 2017: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/28124062/prevalence-of-thyroid-disorders-in%C3%A2-elderly-people-in-germany-a-screening-study-in-a-country-with%C3%A2-endemic-goitre
#16
Frederik A Verburg, Inge Grelle, Kathrin Tatschner, Christoph Reiners, Markus Luster
AIM: In a screening study on people of working age the prevalence of morphological thyroid disorders was 33.1 %. It is not known precisely whether this further increases after retirement. The present study aimed to establish whether the increase in the prevalence of morphological and functional thyroid disorders continues beyond working age in elderly citizens. METHODS: 223 participants were recruited in an institute for geriatric rehabilitative medicine. All patients were screened by thyroid ultrasound, measurement of serum levels of thyroid hormones and thyroid related autoantibodies as well as measurement of urinary iodine excretion...
February 14, 2017: Nuklearmedizin. Nuclear Medicine
https://www.readbyqxmd.com/read/28122781/thyroid-hormone-treatment-among-pregnant-women-with-subclinical-hypothyroidism-us-national-assessment
#17
Spyridoula Maraka, Raphael Mwangi, Rozalina G McCoy, Xiaoxi Yao, Lindsey R Sangaralingham, Naykky M Singh Ospina, Derek T O'Keeffe, Ana E Espinosa De Ycaza, Rene Rodriguez-Gutierrez, Charles C Coddington, Marius N Stan, Juan P Brito, Victor M Montori
OBJECTIVE:  To estimate the effectiveness and safety of thyroid hormone treatment among pregnant women with subclinical hypothyroidism. DESIGN:  Retrospective cohort study. SETTING:  Large US administrative database between 1 January 2010 and 31 December 2014. PARTICIPANTS:  5405 pregnant women with subclinical hypothyroidism, defined as untreated thyroid stimulating hormone (TSH) concentration 2.5-10 mIU/L. EXPOSURE:  Thyroid hormone therapy...
January 25, 2017: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/28101810/increased-incidence-of-autoimmune-thyroid-disorders-in-patients-with-psoriatic-arthritis-a-longitudinal-follow-up-study
#18
Poupak Fallahi, Silvia Martina Ferrari, Ilaria Ruffilli, Giusy Elia, Mario Miccoli, Andrea Delle Sedie, Lucrezia Riente, Alessandro Antonelli
Contrasting results have been reported about the prevalence of thyroid autoimmunity (AT) and dysfunction (TD) in patients with psoriatic arthritis (PsA). In this study, we pointed to evaluate the incidence of new cases of clinical and subclinical TD in a broad group of patients with PsA versus a control group, matched by age and gender belonging to the same geographic area. PsA patients with TD were excluded firstly, and new cases of thyroid disorders were evaluated in 97 PsA patients and 97 matched controls, who had comparable iodine intake (median follow-up of 74 months in PsA versus 92 in controls)...
January 18, 2017: Immunologic Research
https://www.readbyqxmd.com/read/28059636/effects-of-adequate-iodine-supply-on-the-incidence-of-iodine-induced-thyroid-disorders-in-slovenia
#19
Vid Bajuk, Katja Zaletel, Edvard Pirnat, Sergej Hojker, Simona Gaberšček
BACKGROUND: This study aimed to establish the changes in the incidence and characteristics of iodine-induced hyperthyroidism (II-Hyper) and iodine-induced hypothyroidism (II-Hypo) in the two-year period before and the 10-year period after the increase in mandatory salt iodization from the previous 10 mg/kg of potassium iodide to 25 mg/kg in 1999. Furthermore, the aim was to determine the duration of treatment in II-Hyper patients, since no data regarding severity and treatment of II-Hyper with respect to iodine supply are available...
February 1, 2017: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/28038798/cardiovascular-risk-in-chronic-autoimmune-thyroiditis-and-subclinical-hypothyroidism-patients-a-cluster-analysis
#20
Giovanni Carbotta, Francesco Tartaglia, Alessandro Giuliani, Sabino Carbotta, Luciana Tromba, Ilaria Jacomelli, Livia De Anna, Angela Fumarola
BACKGROUND: Subclinical hypothyroidism (SCH) and chronic autoimmune thyroiditis (CAT) are linked to an increased risk of atherosclerosis and coronary heart disease (CHD). The aim of this study was to look for positive markers of CHD and correlations with thyroid blood tests in patients with SCH or CAT, but no symptoms of CHD, so as to identify CHD risk conditions that otherwise would likely be missed. METHODS: We measured a series of thyroid, clinical-metabolic and cardiovascular parameters in 30 consecutive endocrinology patients enrolled in our ambulatory endocrinological referral center of "Sapienza" University of Rome...
March 1, 2017: International Journal of Cardiology
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