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Zinc alpha2 glycoprotein

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https://www.readbyqxmd.com/read/27583927/plasma-zinc-alpha2-glycoprotein-levels-correlate-positively-with-frailty-severity-in-female-elders
#1
Ya-Ping Lee, Chin-Hao Chang, Heng-Hsiu Liu, Chin-Ying Chen, Ching-Yu Chen, Chih-Cheng Hsu, Ching-I Chang, Yen-Ting Lin, Chung-Sheng Lee, Jaw-Shiun Tsai
Frailty is a geriatric syndrome associated with adiposity. Zinc alpha2-glycoprotein (ZAG), a novel adipokine, is a modulator of body fat mass and positively correlates with age. This observational study aims to investigate the relationship between plasma ZAG levels and frailty in the elderly.We enrolled 189 elder participants from a hospital-based comprehensive geriatric assessment program in Taiwan from January 2007 to June 2008. The demographic data, body weight, body mass index, appendicular skeletal muscle mass index (ASMI), body fat mass percentage, metabolic and inflammatory parameters including plasma tumor-necrosis factor alpha, C-reactive protein and ZAG levels, were assessed...
August 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27360276/aerobic-training-decrease-body-fat-may-via-zinc-alpha2-glycoprotein-1357-board-10-june-2-8-00-am-9-30-am
#2
Zhijian Rao, Rengfei Shi, Yun Chang
No abstract text is available yet for this article.
May 2016: Medicine and Science in Sports and Exercise
https://www.readbyqxmd.com/read/27264075/zinc-alpha2-glycoprotein-alleviates-palmitic-acid-induced-intracellular-lipid-accumulation-in-hepatocytes
#3
Xinhua Xiao, Han Li, Xiaoyan Qi, Yadi Wang, Canxin Xu, Gexin Liu, Gebo Wen, Jianghua Liu
Zinc alpha2 glycoprotein (ZAG) plays an important role in stimulating fat mobilization and lipolysis in adipose tissue, but its role in hepatic lipid metabolism remains unclear. Palmitic acid (PA) was used to stimulate HepG2 cells with ZAG overexpression or ZAG knock down (shRNA). Overexpression of ZAG significantly inhibited lipogenesis, promoted lipolysis and fatty acid β-oxidation, and attenuated PA-induced intracellular fat accumulation. Moreover, ZAG overexpression dramatically stimulated adiponectin expression in HepG2 cells...
June 3, 2016: Molecular and Cellular Endocrinology
https://www.readbyqxmd.com/read/25580089/circulating-anti-inflammatory-adipokines-high-molecular-weight-adiponectin-and-zinc-%C3%AE-2-glycoprotein-zag-are-inhibited-in-early-sepsis-but-increase-with-clinical-recovery-a-pilot-study
#4
Ingeborg D Welters, Chen Bing, Cherlyn Ding, Martin Leuwer, Alison M Hall
BACKGROUND: Adipose tissue has been identified as an endocrine organ secreting adipokines involved in metabolic and inflammatory pathways. Adiponectin, an anti-inflammatory adipokine, is reduced in sepsis. High Molecular Weight (HMW) adiponectin, the biologically most relevant molecule, has been investigated very little in human sepsis. Zinc-alpha2-glycoprotein (ZAG) is a novel adipokine and its expression in adipose tissue is positively correlated with adiponectin expression. It is not yet known whether ZAG has a role in sepsis...
2014: BMC Anesthesiology
https://www.readbyqxmd.com/read/25076420/the-relationship-between-renal-function-and-plasma-concentration-of-the-cachectic-factor-zinc-alpha2-glycoprotein-zag-in-adult-patients-with-chronic-kidney-disease
#5
Caroline C Pelletier, Laetitia Koppe, Pascaline M Alix, Emilie Kalbacher, Marine L Croze, Aoumeur Hadj-Aissa, Denis Fouque, Fitsum Guebre-Egziabher, Christophe O Soulage
Zinc-α2-glycoprotein (ZAG), a potent cachectic factor, is increased in patients undergoing maintenance dialysis. However, there is no data for patients before initiation of renal replacement therapy. The purpose of the present study was to assess the relationship between plasma ZAG concentration and renal function in patients with a large range of glomerular filtration rate (GFR). Plasma ZAG concentration and its relationship to GFR were investigated in 71 patients with a chronic kidney disease (CKD) stage 1 to 5, 17 chronic hemodialysis (HD), 8 peritoneal dialysis (PD) and 18 non-CKD patients...
2014: PloS One
https://www.readbyqxmd.com/read/24640423/focus-on-adipokines
#6
REVIEW
Pieranna Fietta, Giovanni Delsante
Once considered a passive reservoir for lipid storage and an inert provider of thermal/mechanical insulation, white adipose tissue (WAT) is presently seen as a highly dynamic endocrine organ that actively modulates a variety of physiologic processes, including energy balance, food intake, inflammation, immunity, metabolism, as well as cardio-vascular (CV) and neuroendocrine homeostasis. Actually, other than fatty acids and lipid moieties, WAT secretes a wide range of bioactive factors, considerably different in therms of structure and functions, including cytokines, chemokines, growth factors, complement system molecules, acute phase reactants, and hormones, among which the products predominantly or exclusively synthesized by and released from adipocytes are categorized as "adipokines"...
2013: Theoretical Biology Forum
https://www.readbyqxmd.com/read/23849457/zinc-alpha2-glycoprotein-in-patients-with-acute-and-chronic-kidney-disease
#7
Inga Sörensen-Zender, Jan Beneke, Bernhard M W Schmidt, Jan Menne, Hermann Haller, Roland Schmitt
BACKGROUND: Zinc-alpha2-glycoprotein (AZGP1) is a secreted protein which is synthesized in a variety of cell types. AZGP1 has functionally been implicated in lipid metabolism, the regulation of cell cycling and cancer progression. Previous studies have shown increased circulating AZGP1 levels in patients with chronic kidney disease but AZGP1 has not been investigated in acute kidney injury (AKI). In this study, serum AZGP1 levels were measured in acute and chronic kidney disease to test for a correlation to renal function and other clinical parameters...
2013: BMC Nephrology
https://www.readbyqxmd.com/read/22625427/decreased-expression-of-zinc-alpha2-glycoprotein-in-hepatocellular-carcinoma-associates-with-poor-prognosis
#8
Yan Huang, Lin-Zi Li, Chris Zhi-Yi Zhang, Chun Yi, Li-Li Liu, Xuan Zhou, Guo-Bing Xie, Mu-Yan Cai, Yan Li, Jing-Ping Yun
BACKGROUND: Zinc-alpha2-glycoprotein (AZGP1, ZAG) was recently demonstrated to be an important factor in tumor carcinogenesis. However, AZGP1 expression in hepatocellular carcinoma (HCC) and its significance remain largely unknown. METHODS: Quantitative real-time polymerase chain reaction (qRT-PCR) was applied to determine mRNA level of AZGP1 in 20 paired fresh HCC tissues. Clinical and pathological data of 246 HCC patients were collected. Tissue-microarray-based immunohistochemistry (IHC) was performed to examine AZGP1 expression in HCC samples...
2012: Journal of Translational Medicine
https://www.readbyqxmd.com/read/21180279/fatty-acid-synthase-and-hormone-sensitive-lipase-expression-in-liver-are-involved-in-zinc-alpha2-glycoprotein-induced-body-fat-loss-in-obese-mice
#9
Feng-Ying Gong, Jie-Ying Deng, Hui-Juan Zhu, Hui Pan, Lin-Jie Wang, Hong-Bo Yang
OBJECTIVE: To explore the effects of zinc-alpha2-glycoprotein (ZAG) on body weight and body fat in high-fat-diet (HFD)-induced obesity in mice and the possible mechanism. METHODS: Thirty-six male mice were fed with standard food (SF) (n = 9) and HFD (n = 27), respectively. Five weeks later, 9 mice fed with HFD were subjected to ZAG expression plasmid DNA transfection by liposome transfection method, and another 9 mice to negative control plasmid transfection. Two weeks later, serum ZAG level in the mice was assayed by Western blot, and the effects of ZAG over-expression on body weight, body fat, serum biochemical indexes, and adipose tissue of obese mice were evaluated...
September 2010: Chinese Medical Sciences Journal, Chung-kuo i Hsüeh K'o Hsüeh Tsa Chih
https://www.readbyqxmd.com/read/20702573/mechanism-of-attenuation-of-skeletal-muscle-atrophy-by-zinc-alpha2-glycoprotein
#10
Steven T Russell, Michael J Tisdale
The mechanism by which the adipokine zinc-α2-glycoprotein (ZAG) increases the mass of gastrocnemius, but not soleus muscle of diabetic mice, has been evaluated both in vivo and in vitro. There was an increased phosphorylation of both double-stranded RNA-dependent protein kinase and its substrate, eukaryotic initiation factor-2α, which was attenuated by about two-thirds in gastrocnemius but not soleus muscle of ob/ob mice treated with ZAG (50 μg, iv daily) for 5 d. ZAG also reduced the expression of the phospho forms of p38MAPK and phospholipase A2, as well as expression of the ubiquitin ligases (E3) muscle atrophy F-box/atrogin-1 and muscle RING finger protein, and the increased activity of both caspase-3 and casapse-8 to values found in nonobese controls...
October 2010: Endocrinology
https://www.readbyqxmd.com/read/20683033/zinc-alpha2-glycoprotein-a-new-biomarker-of-breast-cancer
#11
V Dubois, L Delort, F Mishellany, T Jarde, H Billard, C Lequeux, O Damour, F Penault-Llorca, M P Vasson, F Caldefie-Chezet
BACKGROUND/AIM: Obesity increases the risk of breast cancer. It is established that adipocyte secretions, i.e. adipokines, may play a role in mammary carcinogenesis. We have shown that two major adipokines, leptin and adiponectin, were expressed in mammary adenocarcinoma. PATIENTS AND METHODS: Here, we evaluated zinc-alpha2-glycoprotein (ZAG) expression in tumor (n=55) and healthy (n=6) breast tissue by immunohistochemistry and examined whether it was correlated with that of major adipokines, usual tumor biomarkers (sex steroids receptors, i...
July 2010: Anticancer Research
https://www.readbyqxmd.com/read/20602880/-construction-of-zinc-alpha2-glycoprotein-expression-plasmid-and-its-expression-in-3t3-l1-preadipocytes
#12
Shao-Jun Zhang, Feng-Ying Gong, Jie-Ying Deng, Hui-Juan Zhu, Hui Pan, Dian-Xi Zhang, Nai-Shi Li
OBJECTIVE: To construct mouse Zinc-alpha2-glycoprotein (mZAG) eucaryotic expression plasmid and identify its expression in 3T3-L1 preadipocytes. METHODS: The total RNA from mouse liver tissue was extracted. The reverse-transcript(RT)-PCR method was used to amplify the complete domain sequence of mZAG, and the confirmed PCR products was inserted into expression plasmid by DNA ligation. The mZAG expression plasmids with various concentrations (0, 0.4, 0.8, and 1.6 microg) were transfected into 3T3-L1 preadipocytes, and ZAG expression in mRNA and protein level was determined by real-time fluorescence quantitative PCR and Western blot, respectively...
June 2010: Zhongguo Yi Xue Ke Xue Yuan Xue Bao. Acta Academiae Medicinae Sinicae
https://www.readbyqxmd.com/read/20595026/macrophage-secreted-factors-inhibit-zag-expression-and-secretion-by-human-adipocytes
#13
D Gao, P Trayhurn, C Bing
Zinc-alpha2-glycoprotein (ZAG), a novel adipokine, is downregulated in adipose tissue in obesity, a state characterized by increased adipose tissue macrophage infiltration and chronic low-grade inflammation. This study investigated whether macrophage-secreted factors and TNF-alpha, a major product of macrophages, modulate ZAG expression and secretion by human adipocytes. ZAG was produced primarily by adipocytes, and not by preadipocytes and macrophages. Incubation of preadipocytes with macrophage-conditioned medium for up to 12 days decreased ZAG mRNA and protein release, and the expression of adipogenic markers (PPARgamma and C/EBPalpha)...
August 30, 2010: Molecular and Cellular Endocrinology
https://www.readbyqxmd.com/read/20373865/are-tumoral-factors-responsible-for-host-tissue-wasting-in-cancer-cachexia
#14
Michael J Tisdale
Both cytokines and tumor factors have been implicated in tissue loss in cancer cachexia. Loss of adipose tissue is most likely due to the tumor (and host) factor zinc-alpha2-glycoprotein because of its direct lipolytic effect, ability to sensitize adipocytes to lipolytic stimuli and increased expression in cachexia. TNF-alpha and the tumor factor proteolysis-inducing factor are the major contenders for skeletal muscle atrophy; both increase protein degradation through the ubiquitin-proteasome pathway and depress protein synthesis through phosphorylation of eukaryotic initiation factor 2 alpha...
April 2010: Future Oncology
https://www.readbyqxmd.com/read/20032055/antidiabetic-properties-of-zinc-alpha2-glycoprotein-in-ob-ob-mice
#15
Steven T Russell, Michael J Tisdale
Zinc-alpha(2)-glycoprotein (ZAG) is an adipokine associated with fat loss in cancer cachexia. The purpose of this study was to evaluate the ability of recombinant human ZAG to attenuate type 2 diabetes in the ob/ob mouse model. ZAG (50 microg daily, iv) induced a progressive loss of body weight (3.5 g in 5 d), without an effect on food or water intake but with a 0.4 C rise in body temperature, suggesting an increased energy expenditure. Despite an increased plasma glycerol, indicative of increased lipolysis, levels of glucose, triglycerides, and nonesterified fatty acids were decreased by 17, 25, and 62%, respectively, due to an increased use of both glucose and lipids by muscle and brown adipose tissue...
March 2010: Endocrinology
https://www.readbyqxmd.com/read/19934249/downregulation-of-zinc-alpha-2-glycoprotein-in-adipose-tissue-and-liver-of-obese-ob-ob-mice-and-by-tumour-necrosis-factor-alpha-in-adipocytes
#16
T Mracek, D Gao, T Tzanavari, Y Bao, X Xiao, C Stocker, P Trayhurn, C Bing
Zinc-alpha2-glycoprotein (ZAG, also listed as AZGP1 in the MGI Database), a lipid-mobilising factor, has recently been suggested as a potential candidate in the modulation of body weight. We investigated the effect of increased adiposity on ZAG expression in adipose tissue and the liver and on plasma levels in obese (ob/ob) mice compared with lean siblings. The study also examined the effect of the pro-inflammatory cytokine tumour necrosis factor-alpha (TNFalpha) on ZAG expression in adipocytes. Zag mRNA levels were significantly reduced in subcutaneous (fourfold) and epididymal (eightfold) fat of ob/ob mice...
February 2010: Journal of Endocrinology
https://www.readbyqxmd.com/read/19846741/circulating-and-adipose-tissue-gene-expression-of-zinc-alpha2-glycoprotein-in-obesity-its-relationship-with-adipokine-and-lipolytic-gene-markers-in-subcutaneous-and-visceral-fat
#17
V Ceperuelo-Mallafré, S Näf, X Escoté, E Caubet, J M Gomez, M Miranda, M R Chacon, J M Gonzalez-Clemente, L Gallart, C Gutierrez, J Vendrell
CONTEXT: Zinc-alpha2-glycoprotein (ZAG) is a soluble protein similar to the class I major histocompatibility complex heavy chain, which has been implicated in lipid catabolism. We hypothesized that ZAG mRNA expression in adipose tissue may be linked with lipolytic and adipokine gene expression and have a close relationship with clinical phenotype. OBJECTIVES: The objective of the study was to analyze ZAG gene expression in human adipose tissue from lean and obese subjects...
December 2009: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/19834460/release-of-12-adipokines-by-adipose-tissue-nonfat-cells-and-fat-cells-from-obese-women
#18
John N Fain, Balkachew M Tagele, Paramjeet Cheema, Atul K Madan, David S Tichansky
The relative release in vitro of endothelin-1, zinc-alpha2-glycoprotein (ZAG), lipocalin-2, CD14, RANTES (regulated on activation, normal T cell expressed and secreted protein), lipoprotein lipase (LPL), osteoprotegerin (OPG), fatty acid-binding protein 4 (FABP-4), visfatin/PBEF/Nampt, glutathione peroxidase-3 (GPX-3), intracellular cell adhesion molecule 1 (ICAM-1), and amyloid A was examined using explants of human adipose tissue as well as the nonfat cell fractions and adipocytes from obese women. Over a 48-h incubation the majority of the release of LPL was by fat cells whereas that of lipocalin-2, RANTES, and ICAM-1 was by the nonfat cells present in human adipose tissue...
May 2010: Obesity
https://www.readbyqxmd.com/read/19823091/zinc-alpha2-glycoprotein-in-cachexia-and-obesity
#19
REVIEW
Michael J Tisdale
PURPOSE OF REVIEW: Control of adipose mass is important in the treatment of both cachexia and obesity. This review focuses on a novel adipokine, zinc-alpha2-glycoprotein (ZAG), which plays an important role in the mobilization and utilization of stored lipids. RECENT FINDINGS: An increased lipolysis is responsible for the loss of adipose tissue in cachexia, through an increased lipolytic response to catecholamines, arising from an increased expression of hormone-sensitive lipase...
December 2009: Current Opinion in Supportive and Palliative Care
https://www.readbyqxmd.com/read/19719894/new-insights-into-adipose-tissue-atrophy-in-cancer-cachexia
#20
REVIEW
Chen Bing, Paul Trayhurn
Profound loss of adipose and other tissues is a hallmark of cancer cachexia, a debilitating condition associated with increased morbidity and mortality. Fat loss cannot be attributable to reduced appetite alone as it precedes the onset of anorexia and is much more severe in experimental models of cachexia than in food restriction. Morphological examination has shown marked remodelling of adipose tissue in cancer cachexia. It is characterised by the tissue containing shrunken adipocytes with a major reduction in cell size and increased fibrosis in the tissue matrix...
November 2009: Proceedings of the Nutrition Society
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