Xin-Hua Xiao, Ya-Di Wang, Xiao-Yan Qi, Yuan-Yuan Wang, Jiao-Yang Li, Han Li, Pei-Ying Zhang, Hai-Lin Liao, Mei-Hua Li, Zhe-Zhen Liao, Jing Yang, Can-Xin Xu, Ge-Bo Wen, Jiang-Hua Liu
BACKGROUND/AIM: Nonalcoholic fatty liver disease (NAFLD) is characterized by hepatic steatosis, impaired insulin sensitivity, and chronic low-grade inflammation. Our previous studies indicated that zinc alpha2 glycoprotein (ZAG) alleviates palmitate (PA)-induced intracellular lipid accumulation in hepatocytes. This study is to further characterize the roles of ZAG on the development of hepatic steatosis, insulin resistance (IR), and inflammation. METHODS: ZAG protein levels in the livers of NAFLD patients, high-fat diet (HFD)-induced or genetically (ob/ob) induced obese mice, and in PA-treated hepatocytes were determined by western blotting...
August 2018: International Journal of Obesity