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https://www.readbyqxmd.com/read/29134414/pax3-promotes-cell-migration-and-cxcr4-gene-expression-in-neural-crest-cells
#1
Man Xu, Yongle Li, Jinfeng Du, Hengrong Lin, Sixian Cao, Zuming Mao, Ronghua Wu, Mei Liu, Yan Liu, Qiyou Yin
Neural crest (NC) cells are a multipotent cell population with powerful migration ability during development. C-X-C chemokine receptor type 4 (CXCR4) is a chemokine receptor implicated to mediate NC migration in various species, whereas the underlying mechanism is not well documented yet. PAX3 is a critical transcription factor for the formation of neural crest and the migration and differentiation of NCs. In this study, we retrieved a potential PAX3 binding element in the promoter of the CXCR4 gene, and we further found that PAX3 could promote the expression of CXCR4 and facilitate the migration of NCs...
November 13, 2017: Journal of Molecular Neuroscience: MN
https://www.readbyqxmd.com/read/29133075/spinal-cord-self-repair-during-tail-regeneration-in-polypedates-maculatus-and-putative-role-of-fgf1-as-a-neurotrophic-factor
#2
Jutshina Hota, Sushri Sangita Pati, Pravati Kumari Mahapatra
Spinal cord injury could be fatal in man and often results in irreversible medical conditions affecting mobility. However, anuran amphibians win over such pathological condition by the virtue of regeneration abilities. The tail of anuran tadpoles therefore allures researchers to study spinal cord injury and self- repair process. In the present study, we inflicted injury to the spinal cord by means of surgical transection of the tail and investigated the self-repair activity in the tadpoles of the Indian tree frog Polypedates maculatus...
November 10, 2017: Journal of Chemical Neuroanatomy
https://www.readbyqxmd.com/read/29130147/callous-unemotional-traits-modulate-brain-drug-craving-response-in-high-risk-young-offenders
#3
Gina M Vincent, Lora M Cope, Jean King, Prashanth Nyalakanti, Kent A Kiehl
Adults with psychopathy have a high propensity for substance abuse, generally starting from a young age. This investigation tested hypotheses about differences in the neural responses associated with drug craving among high-risk young offenders with histories of abuse of stimulants and other drugs as a function of psychopathic traits. Fifty-four male adolescents (44 with a history of stimulant abuse and 10 controls) incarcerated at a maximum-security facility (M age = 17.08 years) completed a drug-cue exposure task while brain hemodynamic activity was monitored using functional magnetic resonance imaging (fMRI) with a mobile MRI scanner stationed at the facility...
November 13, 2017: Journal of Abnormal Child Psychology
https://www.readbyqxmd.com/read/29113572/effects-of-an-individual-12-week-community-located-start-to-run-program-on-physical-capacity-walking-fatigue-cognitive-function-brain-volumes-and-structures-in-persons-with-multiple-sclerosis
#4
Peter Feys, Lousin Moumdjian, Florian Van Halewyck, Inez Wens, Bert O Eijnde, Bart Van Wijmeersch, Veronica Popescu, Paul Van Asch
BACKGROUND: Exercise therapy studies in persons with multiple sclerosis (pwMS) primarily focused on motor outcomes in mid disease stage, while cognitive function and neural correlates were only limitedly addressed. OBJECTIVES: This pragmatic randomized controlled study investigated the effects of a remotely supervised community-located "start-to-run" program on physical and cognitive function, fatigue, quality of life, brain volume, and connectivity. METHOD: In all, 42 pwMS were randomized to either experimental (EXP) or waiting list control (WLC) group...
November 1, 2017: Multiple Sclerosis: Clinical and Laboratory Research
https://www.readbyqxmd.com/read/29064411/comparison-between-random-forests-artificial-neural-networks-and-gradient-boosted-machines-methods-of-on-line-vis-nir-spectroscopy-measurements-of-soil-total-nitrogen-and-total-carbon
#5
Said Nawar, Abdul M Mouazen
Accurate and detailed spatial soil information about within-field variability is essential for variable-rate applications of farm resources. Soil total nitrogen (TN) and total carbon (TC) are important fertility parameters that can be measured with on-line (mobile) visible and near infrared (vis-NIR) spectroscopy. This study compares the performance of local farm scale calibrations with those based on the spiking of selected local samples from both fields into an European dataset for TN and TC estimation using three modelling techniques, namely gradient boosted machines (GBM), artificial neural networks (ANNs) and random forests (RF)...
October 24, 2017: Sensors
https://www.readbyqxmd.com/read/29061703/baseline-levels-of-rapid-eye-movement-sleep-may-protect-against-excessive-activity-in-fear-related-neural-circuitry
#6
Itamar Lerner, Shira M Lupkin, Neha Sinha, Alan Tsai, Mark A Gluck
Sleep, and particularly rapid-eye movement sleep (REM), has been implicated in the modulation of neural activity following fear conditioning and extinction in both human and animal studies. It has long been presumed that such effects play a role in the formation and persistence of Post-Traumatic-Stress-disorder, of which sleep impairments are a core feature. However, to date, few studies have thoroughly examined the potential effects of sleep prior to conditioning on subsequent acquisition of fear learning in humans...
October 23, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/29060269/stop-state-classification-in-intracortical-brain-machine-interface
#7
Tze Hui Koh, Camilo Libedinsky, Cuntai Guan, Kai Keng Ang, Rosa Q So
Invasive brain-machine-interface (BMI) has the prospect to empower tetraplegic patients with independent mobility through the use of brain-controlled wheelchairs. For the practical and long-term use of such control systems, the system has to distinguish between stop and movement states and has to be robust to overcome non-stationarity in the brain signals. In this work, we investigates the non-stationarity of the stop state on neural data collected from a macaque trained to control a robotic platform to stop and move in left, right, forward directions We then propose a hybrid approach that employs both random forest and linear discriminant analysis (LDA)...
July 2017: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/29060268/boosting-performance-in-brain-machine-interface-by-classifier-level-fusion-based-on-accumulative-training-models-from-multi-day-data
#8
Huijuan Yang, Camilo Libedinsky, Cuntai Guan, Kai Keng Ang, Rosa Q So
The nonstationarity of neural signal is still an unresolved issue despite the rapid progress made in brain-machine interface (BMI). This paper investigates how to utilize the rich information and dynamics in multi-day data to address the variability in day-to-day signal quality and neural tuning properties. For this purpose, we propose a classifier-level fusion technique to build a robust decoding model by jointly considering the classifier outputs from multiple base-training models using multi-day data collected prior to test day...
July 2017: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/29057352/morphometric-anatomy-of-the-lumbar-sympathetic-trunk-with-respect-to-the-anterolateral-approach-to-lumbar-interbody-fusion-a-cadaver-study
#9
Gareth Rutter, Kevin Phan, Adam Smith, Fiona Stewart, Kevin Seex, Cristian Gragnaniello
BACKGROUND: An approach to lateral lumbar interbody fusion (LLIF) utilizing an oblique corridor anterior to the psoas muscle was first described by Mayer in 1997 and subsequently by other authors. The only consistent structure of note in this corridor is the lumbar sympathetic trunk (LST), which at times must be mobilized in order to perform a discectomy and interbody fusion, thereby placing the LST at risk. This study was designed to describe the morphometric anatomy of the LST in relation to surgically relevant landmarks for the anterolateral approach to the lumbar spine at L3/L4 to L5/S1...
September 2017: Journal of Spine Surgery (Hong Kong)
https://www.readbyqxmd.com/read/29053454/a-data-set-for-camera-independent-color-constancy
#10
Caglar Aytekin, Jarno Nikkanen, Moncef Gabbouj
In this paper, we provide a novel data set designed for Camera-independent color constancy research. Camera independence corresponds to the robustness of an algorithm's performance when it runs on images of the same scene taken by different cameras. Accordingly, the images in our database correspond to several laboratory and field scenes each of which is captured by three different cameras with minimal registration errors. The laboratory scenes are also captured under five different illuminations. The spectral responses of cameras and the spectral power distributions of the laboratory light sources are also provided, as they may prove beneficial for training future algorithms to achieve color constancy...
February 2018: IEEE Transactions on Image Processing: a Publication of the IEEE Signal Processing Society
https://www.readbyqxmd.com/read/29023805/intracranial-source-activity-eloreta-related-to-scalp-level-asymmetry-scores-and-depression-status
#11
Ezra E Smith, James F Cavanagh, John J B Allen
Frontal EEG alpha asymmetry provides a promising index of depression risk, yet very little is known about the neural sources of alpha asymmetry. To identify these sources, this study examined alpha asymmetry using a distributed inverse solution: exact low resolution brain electromagnetic tomography (eLORETA). Findings implicated a generator in lateral midfrontal regions that contributed to both surface asymmetry and depression risk. Participants with any lifetime history of depressive episodes were characterized by less left than right activity in the precentral gyrus and midfrontal gyrus...
October 11, 2017: Psychophysiology
https://www.readbyqxmd.com/read/29021678/surgical-planning-for-cervical-deformity-based-on-a-3d-model
#12
Juan Barges-Coll, Iulia Peciu-Florianu, Sébastien Martiniere, John Michael Duff
The treatment of fixed cervical deformity is complex, but the principles guiding its correction remain the same as in deformity of other spinal regions, with the goal of deformity correction that results in a solid fusion with adequate decompression of the neural elements. In these challenging cases, osteotomies are necessary to mobilize the rigid spine and to obtain the desired correction, but they can be associated with increased risk of complications. Therefore, careful preoperative planning and a complete understanding of the anatomic variations allow patient-tailored approaches with and case specific techniques for the optimal and safe treatment of a variety of complex cervical deformities...
July 2017: Journal of Craniovertebral Junction and Spine
https://www.readbyqxmd.com/read/29021141/use-of-a-dynamic-gait-trainer-for-a-child-with-thoracic-level-spinal-cord-injury
#13
Wendy Altizer, Garey Noritz, Ginny Paleg
Paediatric spinal cord injury (SCI) can result in permanent mobility impairment with consequences for activity, participation and quality of life. This case documents the effect of an overground supported stepping intervention using a dynamic gait trainer. To our knowledge, there are no published studies on this intervention for children with SCI and similar interventions have only been reported in children at American Spinal Injury Association Impairment Scale (AIS) levels B and C.A child with a T10 (thoracic level, vertebra 10), AIS level A injury, sustained at 2 years of age, continued to make gains in all areas including participation, activity, body structure and function over the following 4 years...
October 10, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28973854/proteasome-independent-polyubiquitin-linkage-regulates-synapse-scaffolding-efficacy-and-plasticity
#14
Qi Ma, Hongyu Ruan, Lisheng Peng, Mingjie Zhang, Michaela U Gack, Wei-Dong Yao
Ubiquitination-directed proteasomal degradation of synaptic proteins, presumably mediated by lysine 48 (K48) of ubiquitin, is a key mechanism in synapse and neural circuit remodeling. However, more than half of polyubiquitin (polyUb) species in the mammalian brain are estimated to be non-K48; among them, the most abundant is Lys 63 (K63)-linked polyUb chains that do not tag substrates for degradation but rather modify their properties and activity. Virtually nothing is known about the role of these nonproteolytic polyUb chains at the synapse...
October 10, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28959199/neural-correlates-of-single-and-dual-task-walking-in-the-real-world
#15
Sara Pizzamiglio, Usman Naeem, Hassan Abdalla, Duncan L Turner
Recent developments in mobile brain-body imaging (MoBI) technologies have enabled studies of human locomotion where subjects are able to move freely in more ecologically valid scenarios. In this study, MoBI was employed to describe the behavioral and neurophysiological aspects of three different commonly occurring walking conditions in healthy adults. The experimental conditions were self-paced walking, walking while conversing with a friend and lastly walking while texting with a smartphone. We hypothesized that gait performance would decrease with increased cognitive demands and that condition-specific neural activation would involve condition-specific brain areas...
2017: Frontiers in Human Neuroscience
https://www.readbyqxmd.com/read/28954868/activity-dependence-of-synaptic-vesicle-dynamics
#16
Luca A Forte, Michael W Gramlich, Vitaly A Klyachko
The proper function of synapses relies on efficient recycling of synaptic vesicles. The small size of synaptic boutons has hampered efforts to define the dynamical states of vesicles during recycling. Moreover, whether vesicle motion during recycling is regulated by neural activity remains largely unknown. We combined nanoscale-resolution tracking of individual synaptic vesicles in cultured hippocampal neurons from rats of both sexes with advanced motion analyses to demonstrate that the majority of recently endocytosed vesicles undergo sequences of transient dynamical states including epochs of directed, diffusional, and stalled motion...
November 1, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/28937044/priming-of-the-cells-hypoxic-preconditioning-for-stem-cell-therapy
#17
REVIEW
Zheng Z Wei, Yan-Bing Zhu, James Y Zhang, Myles R McCrary, Song Wang, Yong-Bo Zhang, Shan-Ping Yu, Ling Wei
OBJECTIVE: Stem cell-based therapies are promising in regenerative medicine for protecting and repairing damaged brain tissues after injury or in the context of chronic diseases. Hypoxia can induce physiological and pathological responses. A hypoxic insult might act as a double-edged sword, it induces cell death and brain damage, but on the other hand, sublethal hypoxia can trigger an adaptation response called hypoxic preconditioning or hypoxic tolerance that is of immense importance for the survival of cells and tissues...
October 5, 2017: Chinese Medical Journal
https://www.readbyqxmd.com/read/28933133/the-effect-of-nerve-mobilization-exercise-in-patients-with-rheumatoid-arthritis-a-pilot-study
#18
C-N Lo, G Xia, B P Leung
Rheumatoid arthritis (RA) is an autoimmune disorder characterized by chronic inflammation of the joints. The neurogenic inflammatory mechanism plays an important role in the inflammatory process of RA, and pathological changes in neural tissues in RA have also been noted. We aim to investigate treatment of the nervous system to relieve joint pain and inflammation in RA. Nerve mobilization, a nervous system-specific therapeutic exercise, was applied on RA patients to determine the effect of nerve mobilization on joint inflammation...
September 21, 2017: Reumatismo
https://www.readbyqxmd.com/read/28895027/the-aging-urban-brain-analyzing-outdoor-physical-activity-using-the-emotiv-affectiv-suite-in-older-people
#19
Chris Neale, Peter Aspinall, Jenny Roe, Sara Tilley, Panagiotis Mavros, Steve Cinderby, Richard Coyne, Neil Thin, Gary Bennett, Catharine Ward Thompson
This research directly assesses older people's neural activation in response to a changing urban environment while walking, as measured by electroencephalography (EEG). The study builds on previous research that shows changes in cortical activity while moving through different urban settings. The current study extends this methodology to explore previously unstudied outcomes in older people aged 65 years or more (n = 95). Participants were recruited to walk one of six scenarios pairing urban busy (a commercial street with traffic), urban quiet (a residential street) and urban green (a public park) spaces in a counterbalanced design, wearing a mobile Emotiv EEG headset to record real-time neural responses to place...
September 11, 2017: Journal of Urban Health: Bulletin of the New York Academy of Medicine
https://www.readbyqxmd.com/read/28886555/effects-of-fe-iii-and-quality-of-humic-substances-on-as-v-distribution-in-freshwater-use-of-ultrafiltration-and-kohonen-neural-network
#20
Erik S J Gontijo, Cláudia H Watanabe, Adnívia S C Monteiro, Gilmare A da Silva, Hubert M P Roeser, Andre H Rosa, Kurt Friese
Humic substances (HS) are ubiquitous organic compounds able to affect mobility and availability of arsenic (As) in aquatic systems. Although it is known that associations between HS and As occur mainly via iron (Fe)-cationic bridges, the behaviour and distribution of this metalloid in HS- and Fe-rich environments is still not fully understood. In this paper, the quality of HS from different rivers in Brazil and Germany and its influence on the behaviour of As(V) under different Fe(III) concentrations were investigated...
August 29, 2017: Chemosphere
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