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https://www.readbyqxmd.com/read/28742021/resolving-the-prevalence-of-somatic-transposition-in-drosophila
#1
Christoph Daniel Treiber, Scott Waddell
Somatic transposition in mammals and insects could increase cellular diversity and neural mobilization has been implicated in age-dependent decline. To understand the impact of transposition in somatic cells it is essential to reliably measure the frequency and map locations of new insertions. Here we identified thousands of putative somatic transposon insertions in neurons from individual Drosophila melanogaster using whole-genome sequencing. However, the number of de novo insertions did not correlate with transposon expression or fly age...
July 25, 2017: ELife
https://www.readbyqxmd.com/read/28734105/effects-of-median-nerve-neural-mobilization-in-treating-cervicobrachial-pain-a-randomized-waiting-list-controlled-clinical-trial
#2
David Rodríguez-Sanz, Daniel López-López, Francisco Unda-Solano, Carlos Romero-Morales, Irene Sanz-Corbalán, Hector Beltrán-Alacreu, César Calvo-Lobo
BACKGROUND: There is a current lack of sufficiently high-quality randomized controlled clinical trials that measure the effectiveness of neural tissue mobilization techniques such as median nerve neural mobilization (MNNM) and their specific effects on cervicobrachial pain (CP). This study aim was to compare the effectiveness of MNNM in subjects with CP versus a waiting list control group (WLCG). METHODS: A single-blinded, parallel, randomized controlled clinical trial was performed (NCT02596815)...
July 22, 2017: Pain Practice: the Official Journal of World Institute of Pain
https://www.readbyqxmd.com/read/28729899/evolutionary-loss-of-melanogenesis-in-the-tunicate-molgula-occulta
#3
Claudia Racioppi, Maria Carmen Valoroso, Ugo Coppola, Elijah K Lowe, C Titus Brown, Billie J Swalla, Lionel Christiaen, Alberto Stolfi, Filomena Ristoratore
BACKGROUND: Analyzing close species with diverse developmental modes is instrumental for investigating the evolutionary significance of physiological, anatomical and behavioral features at a molecular level. Many examples of trait loss are known in metazoan populations living in dark environments. Tunicates are the closest living relatives of vertebrates and typically present a lifecycle with distinct motile larval and sessile adult stages. The nervous system of the motile larva contains melanized cells associated with geotactic and light-sensing organs...
2017: EvoDevo
https://www.readbyqxmd.com/read/28713615/effects-of-radiofrequency-exposure-emitted-from-a-gsm-mobile-phone-on-proliferation-differentiation-and-apoptosis-of-neural-stem-cells
#4
Mahsa Eghlidospour, Amir Ghanbari, Seyyed Mohammad Javad Mortazavi, Hassan Azari
Due to the importance of neural stem cells (NSCs) in plasticity of the nervous system and treating neurodegenerative diseases, the main goal of this study was to evaluate the effects of radiofrequency radiation emitted from a GSM 900-MHz mobile phone with different exposure duration on proliferation, differentiation and apoptosis of adult murine NSCs in vitro. We used neurosphere assay to evaluate NSCs proliferation, and immunofluorescence assay of neural cell markers to examine NSCs differentiation. We also employed alamarBlue and caspase 3 apoptosis assays to assess harmful effects of mobile phone on NSCs...
June 2017: Anatomy & Cell Biology
https://www.readbyqxmd.com/read/28713345/experimental-study-and-ann-dual-time-scale-perturbation-model-of-electrokinetic-properties-of-microbiota
#5
Yong Liu, Cristian R Munteanu, Carlos Fernandez-Lozano, Alejandro Pazos, Tao Ran, Zhiliang Tan, Yizun Yu, Chuanshe Zhou, Shaoxun Tang, Humberto González-Díaz
The electrokinetic properties of the rumen microbiota are involved in cell surface adhesion and microbial metabolism. An in vitro study was carried out in batch culture to determine the effects of three levels of special surface area (SSA) of biomaterials and four levels of surface tension (ST) of culture medium on electrokinetic properties (Zeta potential, ξ; electrokinetic mobility, μe), fermentation parameters (volatile fatty acids, VFAs), and ST over fermentation processes (ST-a, γ). The obtained results were combined with previously published data (digestibility, D; pH; concentration of ammonia nitrogen, c(NH3-N)) to establish a predictive artificial neural network (ANN) model...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28713255/the-impact-of-aerobic-exercise-on-fronto-parietal-network-connectivity-and-its-relation-to-mobility-an-exploratory-analysis-of-a-6-month-randomized-controlled-trial
#6
Chun L Hsu, John R Best, Shirley Wang, Michelle W Voss, Robin G Y Hsiung, Michelle Munkacsy, Winnie Cheung, Todd C Handy, Teresa Liu-Ambrose
Impaired mobility is a major concern for older adults and has significant consequences. While the widely accepted belief is that improved physical function underlies the effectiveness of targeted exercise training in improving mobility and reducing falls, recent evidence suggests cognitive and neural benefits gained through exercise may also play an important role in promoting mobility. However, the underlying neural mechanisms of this relationship are currently unclear. Thus, we hypothesize that 6 months of progressive aerobic exercise training would alter frontoparietal network (FPN) connectivity during a motor task among older adults with mild subcortical ischemic vascular cognitive impairment (SIVCI)-and exercise-induced changes in FPN connectivity would correlate with changes in mobility...
2017: Frontiers in Human Neuroscience
https://www.readbyqxmd.com/read/28713254/short-term-effects-of-thoracic-spine-manipulation-on-the-biomechanical-organisation-of-gait-initiation-a-randomized-pilot-study
#7
Sébastien Ditcharles, Eric Yiou, Arnaud Delafontaine, Alain Hamaoui
Speed performance during gait initiation is known to be dependent on the capacity of the central nervous system to generate efficient anticipatory postural adjustments (APA). According to the posturo-kinetic capacity (PKC) concept, any factor enhancing postural chain mobility and especially spine mobility, may facilitate the development of APA and thus speed performance. "Spinal Manipulative Therapy High-Velocity, Low-Amplitude" (SMT-HVLA) is a healing technique applied to the spine which is routinely used by healthcare practitioners to improve spine mobility...
2017: Frontiers in Human Neuroscience
https://www.readbyqxmd.com/read/28704626/the-effectiveness-of-neural-mobilization-for-neuro-musculoskeletal-conditions-a-systematic-review-and-meta-analysis
#8
Annalie Basson, Benita Olivier, Richard Ellis, Michel Coppieters, Aimee Stewart, Witness Mudzi
Study Design Systematic review with meta-analysis. Background Neural mobilization (NM) or neurodynamics is a movement-based intervention aimed at restoring the homeostasis in and around the nervous system. The current level of evidence for NM is largely unknown. Objectives To determine the efficacy of NM for musculoskeletal conditions with a neuropathic component. Methods Databases were searched for randomised trials investigating the effect of NM for neuro-musculoskeletal conditions. Standard methods for article identification, selection and quality appraisal were used...
July 13, 2017: Journal of Orthopaedic and Sports Physical Therapy
https://www.readbyqxmd.com/read/28700423/sox2-gene-amplification-and-overexpression-is-linked-to-hpv-positive-vulvar-carcinomas
#9
André Gut, Holger Moch, Matthias Choschzick
SOX2 (SRY-related HMG-box 2) belongs to the SOX gene family of high-mobility transcription factors indispensably involved in gene regulation in pluripotent stem cells and neural differentiation. SOX2 copy number increases have been frequently reported in various types of squamous cell cancer. To better understand the effect of SOX2 aberrations on vulvar cancer phenotype and patient prognosis, we analyzed SOX2 copy number changes using fluorescence in situ hybridization and SOX2 expression by immunohistochemistry in 55 squamous cell carcinomas of the vulva...
July 11, 2017: International Journal of Gynecological Pathology
https://www.readbyqxmd.com/read/28693821/synchronizing-midi-and-wireless-eeg-measurements-during-natural-piano-performance
#10
Anna Zamm, Caroline Palmer, Anna-Katharina R Bauer, Martin G Bleichner, Alexander P Demos, Stefan Debener
Although music performance has been widely studied in the behavioural sciences, less work has addressed the underlying neural mechanisms, perhaps due to technical difficulties in acquiring high-quality neural data during tasks requiring natural motion. The advent of wireless electroencephalography (EEG) presents a solution to this problem by allowing for neural measurement with minimal motion artefacts. In the current study, we provide the first validation of a mobile wireless EEG system for capturing the neural dynamics associated with piano performance...
July 7, 2017: Brain Research
https://www.readbyqxmd.com/read/28690439/grasshopper-dcmd-an-undergraduate-electrophysiology-lab-for-investigating-single-unit-responses-to-behaviorally-relevant-stimuli
#11
Dieu My T Nguyen, Mark Roper, Stanislav Mircic, Robert M Olberg, Gregory J Gage
Avoiding capture from a fast-approaching predator is an important survival skill shared by many animals. Investigating the neural circuits that give rise to this escape behavior can provide a tractable demonstration of systems-level neuroscience research for undergraduate laboratories. In this paper, we describe three related hands-on exercises using the grasshopper and affordable technology to bring neurophysiology, neuroethology, and neural computation to life and enhance student understanding and interest...
2017: Journal of Undergraduate Neuroscience Education: JUNE: a Publication of FUN, Faculty for Undergraduate Neuroscience
https://www.readbyqxmd.com/read/28686117/predicting-ischemic-stroke-after-carotid-artery-stenting-based-on-proximal-calcification-and-the-jellyfish-sign
#12
Nobuhiko Ichinose, Seiji Hama, Toshio Tsuji, Zu Soh, Hideaki Hayashi, Yoshihiro Kiura, Shigeyuki Sakamoto, Takahito Okazaki, Daizo Ishii, Katsuhiro Shinagawa, Kaoru Kurisu
OBJECTIVE Carotid artery stenting (CAS) has been considered to prevent ischemic strokes caused by stenosis of the cervical carotid artery. The most common complication of CAS is new cerebral infarction. The authors have previously reported that the jellyfish sign-the rise and fall of the mobile component of the carotid plaque surface detected by carotid ultrasonography-suggests thinning and rupture of the fibrous cap over the unstable plaque content, such as the lipid-rich necrotic core or internal plaque hemorrhage...
July 7, 2017: Journal of Neurosurgery
https://www.readbyqxmd.com/read/28669601/electrical-guidance-of-human-stem-cells-in-the-rat-brain
#13
Jun-Feng Feng, Jing Liu, Lei Zhang, Ji-Yao Jiang, Michael Russell, Bruce G Lyeth, Jan A Nolta, Min Zhao
Limited migration of neural stem cells in adult brain is a roadblock for the use of stem cell therapies to treat brain diseases and injuries. Here, we report a strategy that mobilizes and guides migration of stem cells in the brain in vivo. We developed a safe stimulation paradigm to deliver directional currents in the brain. Tracking cells expressing GFP demonstrated electrical mobilization and guidance of migration of human neural stem cells, even against co-existing intrinsic cues in the rostral migration stream...
July 11, 2017: Stem Cell Reports
https://www.readbyqxmd.com/read/28658883/artificial-neural-network-ann-model-to-predict-depression-among-geriatric-population-at-a-slum-in-kolkata-india
#14
Arkaprabha Sau, Ishita Bhakta
INTRODUCTION: Depression is one of the most important causes of mortality and morbidity among the geriatric population. Although, the aging brain is more vulnerable to depression, it cannot be considered as physiological and an inevitable part of ageing. Various sociodemographic and morbidity factors are responsible for the depression among them. Using Artificial Neural Network (ANN) model depression can be predicted from various sociodemographic variables and co morbid conditions even at community level by the grass root level health care workers...
May 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28656608/flexible-ionic-electronic-hybrid-oxide-synaptic-tfts-with-programmable-dynamic-plasticity-for-brain-inspired-neuromorphic-computing
#15
Rohit Abraham John, Jieun Ko, Mohit R Kulkarni, Naveen Tiwari, Nguyen Anh Chien, Ng Geok Ing, Wei Lin Leong, Nripan Mathews
Emulation of biological synapses is necessary for future brain-inspired neuromorphic computational systems that could look beyond the standard von Neuman architecture. Here, artificial synapses based on ionic-electronic hybrid oxide-based transistors on rigid and flexible substrates are demonstrated. The flexible transistors reported here depict a high field-effect mobility of ≈9 cm(2) V(-1) s(-1) with good mechanical performance. Comprehensive learning abilities/synaptic rules like paired-pulse facilitation, excitatory and inhibitory postsynaptic currents, spike-time-dependent plasticity, consolidation, superlinear amplification, and dynamic logic are successfully established depicting concurrent processing and memory functionalities with spatiotemporal correlation...
June 28, 2017: Small
https://www.readbyqxmd.com/read/28653995/nutrinet-a-deep-learning-food-and-drink-image-recognition-system-for-dietary-assessment
#16
Simon Mezgec, Barbara Koroušić Seljak
Automatic food image recognition systems are alleviating the process of food-intake estimation and dietary assessment. However, due to the nature of food images, their recognition is a particularly challenging task, which is why traditional approaches in the field have achieved a low classification accuracy. Deep neural networks have outperformed such solutions, and we present a novel approach to the problem of food and drink image detection and recognition that uses a newly-defined deep convolutional neural network architecture, called NutriNet...
June 27, 2017: Nutrients
https://www.readbyqxmd.com/read/28638333/switching-adaptability-in-human-inspired-sidesteps-a-minimal-model
#17
Keisuke Fujii, Yuki Yoshihara, Hiroko Tanabe, Yuji Yamamoto
Humans can adapt to abruptly changing situations by coordinating redundant components, even in bipedality. Conventional adaptability has been reproduced by various computational approaches, such as optimal control, neural oscillator, and reinforcement learning; however, the adaptability in bipedal locomotion necessary for biological and social activities, such as unpredicted direction change in chase-and-escape, is unknown due to the dynamically unstable multi-link closed-loop system. Here we propose a switching adaptation model for performing bipedal locomotion by improving autonomous distributed control, where autonomous actuators interact without central control and switch the roles for propulsion, balancing, and leg swing...
2017: Frontiers in Human Neuroscience
https://www.readbyqxmd.com/read/28637597/effects-of-lower-body-quadrant-neural-mobilization-in-healthy-and-low-back-pain-populations-a-systematic-review-and-meta-analysis
#18
REVIEW
Tiago Neto, Sandro R Freitas, Marta Marques, Luis Gomes, Ricardo Andrade, Raúl Oliveira
BACKGROUND: Neural mobilization (NM) is widely used to assess and treat several neuromuscular disorders. However, information regarding the NM effects targeting the lower body quadrant is scarce. OBJECTIVES: To determine the effects of NM techniques targeting the lower body quadrant in healthy and low back pain (LBP) populations. DESIGN: Systematic review with meta-analysis. METHOD: Randomized controlled trials were included if any form of NM was applied to the lower body quadrant...
February 2017: Musculoskeletal Science & Practice
https://www.readbyqxmd.com/read/28627598/curcumin-exerts-its-tumor-suppressive-function-via-inhibition-of-nedd4-oncoprotein-in-glioma-cancer-cells
#19
Xue Wang, Jiaojiao Deng, Jinxia Yuan, Xin Tang, Yuelong Wang, Haifeng Chen, Yi Liu, Liangxue Zhou
Glioblastoma is the most common brain cancer in adults. It represents one of the top ten malignant tumors with an average survival time of nine months despite treatments with surgery, radiotherapy and chemotherapy. Curcumin is a phytochemical turmeric isolated from root of the Curcuma longa plant. Accumulating evidence have proved that curcumin targets numerous cancer signaling pathways. The E3 ubiquitin ligase NEDD4, neural precursor cell expressed developmentally downregulated protein 4, is frequently overexpressed in various cancers...
June 8, 2017: International Journal of Oncology
https://www.readbyqxmd.com/read/28616913/-the-effect-of-exogenous-recombinant-hmgb1-on-neural-stem-cells-and-related-mechanism
#20
Hui-Min Zhang, Bo Wu, Tian Cao, Yu-Ying Yan, Ming Liu
OBJECTIVES: To explore the effect of exogenous recombinant high mobility group protein box1 (rHMGB1) on proliferation and differentiation of neural stem cells (NSCs) and the related mechanism. METHODS: SD rat cerebral cortex cells were cultured in serum-free medium, extending the culture and purification of neural stem cells. NSCs were identified by detecting nestin-label with immunofluorescence method.The NSCs proliferation activity after adding different concentrations of rHMGB1 was determined by CCK-8 assay and the optimal concentration of rHMGB1 for the follow-up experiments was selected...
May 2017: Sichuan da Xue Xue Bao. Yi Xue Ban, Journal of Sichuan University. Medical Science Edition
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