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https://www.readbyqxmd.com/read/27904801/midfoot-and-forefoot-involvement-in-lateral-ankle-sprains-and-chronic-ankle-instability-part-1-anatomy-and-biomechanics
#1
John J Fraser, Mark A Feger, Jay Hertel
: The modern human foot is the culmination of more than five million years of evolution. The ankle-foot complex absorbs forces during loading, accommodates uneven surfaces, and acts as a lever for efficient propulsion. The ankle-foot complex has six independent functional segments that should be understood for proper assessment and treatment of foot and ankle injuries: the shank, rearfoot, midfoot, lateral forefoot, and the medial forefoot. The compliance of the individual segments of the foot is dependent on velocity, task, and active and passive coupling mechanisms within each of the foot segments...
December 2016: International Journal of Sports Physical Therapy
https://www.readbyqxmd.com/read/27904702/ethanol-extracts-from-portulaca-oleracea-l-attenuated-ischemia-reperfusion-induced-rat-neural-injury-through-inhibition-of-hmgb1-induced-inflammation
#2
Chenggang Zheng, Chen Liu, Wanyin Wang, Gusheng Tang, Liwei Dong, Juan Zhou, Zhengrong Zhong
It is well demonstrated that the high mobility group box 1 (HMGB1) mediated inflammation has been implicated as one of the important causes for brain damage induced by cerebral ischemia/reperfusion (I/R). In the present study, we assessed the neuro-protective and anti-inflammation effects of the ethanol extracts from Portulaca oleracea L. (EEPO) against cerebral I/R injury in the rat transient middle cerebral artery occlusion (tMCAO) model. Rats were administrated with their respective treatment for 7 days before the MCA occlusion...
2016: American Journal of Translational Research
https://www.readbyqxmd.com/read/27882149/combination-of-endogenous-neural-stem-cell-mobilization-and-lithium-chloride-treatment-for-hydrocephalus-following-intraventricular-hemorrhage
#3
Qiang Yuan, Xing-Yao Bu, Zhao-Yue Yan, Xian-Zhi Liu, Zhen-Yu Wei, Chun-Xiao Ma, Ming-Qi Qu
As there are multiple factors causing hydrocephalus subsequent to intraventricular hemorrhage (IVH), it is difficult to achieve the best treatment effect using a single drug alone. In the present study, the protective effect of combination treatment with granulocyte-colony stimulating factor (G-CSF) and lithium chloride against hydrocephalus after IVH was investigated. A total of 130 adult male Sprague-Dawley rats were divided into five groups, including the IVH control, G-CSF treatment, lithium chloride treatment, combination treatment and sham surgery groups...
November 2016: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/27877123/mobility-and-upright-posture-are-associated-with-different-aspects-of-cognition-in-older-adults
#4
Rajal G Cohen, Anita N Vasavada, Michelle M Wiest, Maureen Schmitter-Edgecombe
Objectives: Aging is associated with cognitive decline, including visuomotor and memory concerns, and with motor system changes, including gait slowing and stooped posture. We investigated the associations of visuomotor performance and episodic memory with motor system characteristics in healthy older adults. Methods: Neurologically healthy older adults (N = 160, aged 50-89) completed a battery of cognitive and motor tasks. Cognitive variables were grouped by principal components analysis (PCA) into two components: visuomotor performance and verbal episodic memory...
2016: Frontiers in Aging Neuroscience
https://www.readbyqxmd.com/read/27872811/failure-to-mobilize-cognitive-control-for-challenging-tasks-correlates-with-symptom-severity-in-schizophrenia
#5
Bengi Baran, F Işık Karahanoğlu, Yigal Agam, Leonidas Mantonakis, Dara S Manoach
Deficits in the adaptive, flexible control of behavior contribute to the clinical manifestations of schizophrenia. We used functional MRI and an antisaccade paradigm to examine the neural correlates of cognitive control deficits and their relations to symptom severity. Thirty-three chronic medicated outpatients with schizophrenia and 31 healthy controls performed an antisaccade paradigm. We examined differences in recruitment of the cognitive control network and task performance for Hard (high control) versus Easy (low control) antisaccade trials within and between groups...
2016: NeuroImage: Clinical
https://www.readbyqxmd.com/read/27857638/changes-in-muscle-spasticity-in-patients-with-cerebral-palsy-after-spinal-manipulation-case-series
#6
Oleh Kachmar, Taras Voloshyn, Mykhailo Hordiyevych
OBJECTIVE: The purpose of this case series was to report quantitative changes in wrist muscle spasticity in children with cerebral palsy after 1 spinal manipulation (SM) and a 2-week course of treatment. METHODS: Twenty-nine patients, aged 7 to 18 years, with spastic forms of cerebral palsy and without fixed contracture of the wrist, were evaluated before initiation of treatment, after 1 SM, and at the end of a 2-week course of treatment. Along with daily SM, the program included physical therapy, massage, reflexotherapy, extremity joint mobilization, mechanotherapy, and rehabilitation computer games for 3 to 4 hours' duration...
December 2016: Journal of Chiropractic Medicine
https://www.readbyqxmd.com/read/27856005/mobile-universal-lexicon-evaluation-system-mules-test-a-new-measure-of-rapid-picture-naming-for-concussion
#7
Lucy Cobbs, Lisena Hasanaj, Prin Amorapanth, John-Ross Rizzo, Rachel Nolan, Liliana Serrano, Jenelle Raynowska, Janet C Rucker, Barry D Jordan, Steven L Galetta, Laura J Balcer
OBJECTIVE: This study introduces a rapid picture naming test, the Mobile Universal Lexicon Evaluation System (MULES), as a novel, vision-based performance measure for concussion screening. The MULES is a visual-verbal task that includes 54 original photographs of fruits, objects and animals. We piloted MULES in a cohort of volunteers to determine feasibility, ranges of picture naming responses, and the relation of MULES time scores to those of King-Devick (K-D), a rapid number naming test...
November 4, 2016: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/27853419/benchmarking-spike-based-visual-recognition-a-dataset-and-evaluation
#8
Qian Liu, Garibaldi Pineda-García, Evangelos Stromatias, Teresa Serrano-Gotarredona, Steve B Furber
Today, increasing attention is being paid to research into spike-based neural computation both to gain a better understanding of the brain and to explore biologically-inspired computation. Within this field, the primate visual pathway and its hierarchical organization have been extensively studied. Spiking Neural Networks (SNNs), inspired by the understanding of observed biological structure and function, have been successfully applied to visual recognition and classification tasks. In addition, implementations on neuromorphic hardware have enabled large-scale networks to run in (or even faster than) real time, making spike-based neural vision processing accessible on mobile robots...
2016: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/27843499/evidence-for-l1-associated-dna-rearrangements-and-negligible-l1-retrotransposition-in-glioblastoma-multiforme
#9
Patricia E Carreira, Adam D Ewing, Guibo Li, Stephanie N Schauer, Kyle R Upton, Allister C Fagg, Santiago Morell, Michaela Kindlova, Patricia Gerdes, Sandra R Richardson, Bo Li, Daniel J Gerhardt, Jun Wang, Paul M Brennan, Geoffrey J Faulkner
BACKGROUND: LINE-1 (L1) retrotransposons are a notable endogenous source of mutagenesis in mammals. Notably, cancer cells can support unusual L1 retrotransposition and L1-associated sequence rearrangement mechanisms following DNA damage. Recent reports suggest that L1 is mobile in epithelial tumours and neural cells but, paradoxically, not in brain cancers. RESULTS: Here, using retrotransposon capture sequencing (RC-seq), we surveyed L1 mutations in 14 tumours classified as glioblastoma multiforme (GBM) or as a lower grade glioma...
2016: Mobile DNA
https://www.readbyqxmd.com/read/27842937/effectiveness-of-nerve-gliding-exercises-on-carpal-tunnel-syndrome-a-systematic-review
#10
Ruth Ballestero-Pérez, Gustavo Plaza-Manzano, Alicia Urraca-Gesto, Flor Romo-Romo, María de Los Ángeles Atín-Arratibel, Daniel Pecos-Martín, Tomás Gallego-Izquierdo, Natalia Romero-Franco
OBJECTIVE: The objective of this study was to review the literature regarding the effectiveness of neural gliding exercises for the management of carpal tunnel syndrome (CTS). METHODS: A computer-based search was completed through May 2014 in PubMed, Physiotherapy Evidence Database (PEDro), Web of Knowledge, Cochrane Plus, and CINAHL. The following key words were included: nerve tissue, gliding, exercises, carpal tunnel syndrome, neural mobilization, and neurodynamic mobilization...
November 11, 2016: Journal of Manipulative and Physiological Therapeutics
https://www.readbyqxmd.com/read/27806074/a-novel-robot-system-integrating-biological-and-mechanical-intelligence-based-on-dissociated-neural-network-controlled-closed-loop-environment
#11
Yongcheng Li, Rong Sun, Yuechao Wang, Hongyi Li, Xiongfei Zheng
We propose the architecture of a novel robot system merging biological and artificial intelligence based on a neural controller connected to an external agent. We initially built a framework that connected the dissociated neural network to a mobile robot system to implement a realistic vehicle. The mobile robot system characterized by a camera and two-wheeled robot was designed to execute the target-searching task. We modified a software architecture and developed a home-made stimulation generator to build a bi-directional connection between the biological and the artificial components via simple binomial coding/decoding schemes...
2016: PloS One
https://www.readbyqxmd.com/read/27795917/hmgb1-level-in-cerebrospinal-fluid-as-a-complimentary-biomarker-for-the-diagnosis-of-tuberculous-meningitis
#12
Yan Chen, Jun Zhang, Xiaofei Wang, Yu Wu, Li Zhu, Longkun Lu, Qian Shen, Yanghua Qin
PURPOSE: High mobility group box-1 (HMGB1) is a proinflammatory, DAMP protein that participates in many pathological conditions. In this study, we evaluated the usability of CSF HMGB1 as a biomarker for the diagnosis of tuberculous meningitis (TBM). METHODS: A total of 59 TBM patients and 169 control patients were included in our study. CSF samples were obtained and analyzed for HMGB1 using a commercial ELISA kit. RESULTS: The mean CSF HMGB1 was 19...
2016: SpringerPlus
https://www.readbyqxmd.com/read/27772776/brain-activation-changes-during-locomotion-in-middle-aged-to-older-adults-with-multiple-sclerosis
#13
Manuel E Hernandez, Roee Holtzer, Gioella Chaparro, Kharine Jean, Julia M Balto, Brian M Sandroff, Meltem Izzetoglu, Robert W Motl
Mobility and cognitive impairments are common in persons with multiple sclerosis (MS), and are expected to worsen with increasing age. However, no studies, to date, in part due to limitations of conventional neuroimaging methods, have examined changes in brain activation patterns during active locomotion in older patients with MS. This study used functional Near Infrared Spectroscopy (fNIRS) to evaluate real-time neural activation differences in the pre-frontal cortex (PFC) between middle-aged to older adults with MS and healthy controls during single (Normal Walk; NW) and dual-task (Walking While Talking; WWT) locomotion tasks...
November 15, 2016: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/27769412/prediction-of-fermentation-index-of-cocoa-beans-theobroma-cacao-l-based-on-color-measurement-and-artificial-neural-networks
#14
Noemí León-Roque, Mohamed Abderrahim, Luis Nuñez-Alejos, Silvia M Arribas, Luis Condezo-Hoyos
Several procedures are currently used to assess fermentation index (FI) of cocoa beans (Theobroma cacao L.) for quality control. However, all of them present several drawbacks. The aim of the present work was to develop and validate a simple image based quantitative procedure, using color measurement and artificial neural network (ANNs). ANN models based on color measurements were tested to predict fermentation index (FI) of fermented cocoa beans. The RGB values were measured from surface and center region of fermented beans in images obtained by camera and desktop scanner...
December 1, 2016: Talanta
https://www.readbyqxmd.com/read/27767042/oxytocin-modulates-gabaar-subunits-to-confer-neuroprotection-in-stroke-in-vitro
#15
Yuji Kaneko, Colleen Pappas, Naoki Tajiri, Cesar V Borlongan
Oxytocin protects against ischemia-induced inflammation and oxidative stress, and is associated with GABA (γ-aminobutyric acid, an inhibitory neurotransmitter) signaling transduction in neurons. However, the molecular mechanism by which oxytocin affords neuroprotection, especially the interaction between oxytocin receptor and GABAA receptor (GABAAR), remains to be elucidated. Primary rat neural cells were exposed to oxytocin before induction of experimental acute stroke model via oxygen-glucose deprivation-reperfusion (OGD/R) injury...
October 21, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27766641/physiological-and-neural-correlates-of-worry-and-rumination-support-for-the-contrast-avoidance-model-of-worry
#16
Elisa C K Steinfurth, Manuela G Alius, Julia Wendt, Alfons O Hamm
The current experiments tested neural and physiological correlates of worry and rumination in comparison to thinking about neutral events. According to the avoidance model-stating that worry is a strategy to reduce intense emotions-physiological and neurobiological activity during worried thinking should not differ from activation during neutral thinking. According to the contrast avoidance model-stating that worry is a strategy to reduce abrupt shifts of emotions-activity should be increased. To test these competing models, we induced worry and neutral thinking in healthy participants using personal topics...
October 21, 2016: Psychophysiology
https://www.readbyqxmd.com/read/27763881/neuropathic-ulcers-among-children-with-neural-tube-defects-a-review-of-literature
#17
Anand Pandey, Vipin Gupta, Shailendra P Singh, Vijendra Kumar, Rajesh Verma
A trophic ulcer is a pressure ulcer caused by external trauma to a part of the body that is compromised due to disease, vascular insufficiency, or loss of afferent nerve fibers. Spinal dysraphism (ie, neural tube defects [NTD]) such as meningomyelocele is a risk factor for developing these ulcers in adults and pediatric patients. Information regarding the occurrence of trophic ulcers in pediatric patients with NTD is lacking. A review of the English-language literature on skin/neuropathic ulcers in patients with NTDs, irrespective of study design, published between 1975 and 2014, was undertaken using the PubMed database...
December 2015: Ostomy/wound Management
https://www.readbyqxmd.com/read/27748109/long-term-synaptic-plasticity-emulated-in-modified-graphene-oxide-electrolyte-gated-izo-based-thin-film-transistors
#18
Yi Yang, Juan Wen, Liqiang Guo, Xiang Wan, Peifu Du, Ping Feng, Yi Shi, Qing Wan
Emulating neural behaviors at the synaptic level is of great significance for building neuromorphic computational systems and realizing artificial intelligence. Here, oxide-based electric-double-layer (EDL) thin-film transistors were fabricated by using 3-triethoxysilylpropylamine modified graphene oxide (KH550-GO) electrolyte as the gate dielectrics. Resulting from the EDL effect and electrochemical doping between mobile protons and the indium-zinc-oxide channel layer, long-term synaptic plasticity was emulated in our devices...
October 17, 2016: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/27743012/sensitivity-of-the-avian-motion-system-to-light-and-dark-stimuli
#19
Jean-François Nankoo, Christopher R Madan, Marcia L Spetch, Douglas R Wylie
Global motion perception is important for mobile organisms. In laterally eyed birds, global motion appears to be processed in the entopallium, a neural structure that is part of the tectofugal pathway. Electrophysiological research has shown that motion selective cells in the entopallium are most responsive to small dark moving targets. Here, we investigated whether this bias toward dark targets of entopallial cells is mirrored by perceptual performance in a motion detection task in pigeons. We measured the detection thresholds of pigeons using random dot stimuli that consisted of either black or white dots on a gray background...
October 14, 2016: Experimental Brain Research. Experimentelle Hirnforschung. Expérimentation Cérébrale
https://www.readbyqxmd.com/read/27719881/hypnosis-as-a-model-of-functional-neurologic-disorders
#20
Q Deeley
In the 19th century it was recognized that neurologic symptoms could be caused by "morbid ideation" as well as organic lesions. The subsequent observation that hysteric (now called "functional") symptoms could be produced and removed by hypnotic suggestion led Charcot to hypothesize that suggestion mediated the effects of ideas on hysteric symptoms through as yet unknown effects on brain activity. The advent of neuroimaging 100 years later revealed strikingly similar neural correlates in experiments matching functional symptoms with clinical analogs created by suggestion...
2017: Handbook of Clinical Neurology
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