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https://www.readbyqxmd.com/read/28301805/the-protective-role-of-plant-biophenols-in-mechanisms-of-alzheimer-s-disease
#1
REVIEW
Syed H Omar, Christopher J Scott, Adam S Hamlin, Hassan K Obied
Self-assembly of amyloid beta peptide (Aβ) into the neurotoxic oligomers followed by fibrillar aggregates is a defining characteristic of Alzheimer's disease (AD). Several lines of proposed hypotheses have suggested the mechanism of AD pathology, though the exact pathophysiological mechanism is not yet elucidated. The poor understanding of AD and multitude of adverse responses reported from the current synthetic drugs are the leading cause of failure in the drug development to treat or halt the progression of AD and mandate the search for safer and more efficient alternatives...
March 3, 2017: Journal of Nutritional Biochemistry
https://www.readbyqxmd.com/read/28296300/experimental-validation-of-a-kv-source-model-and-dose-computation-method-for-cbct-imaging-in-an-anthropomorphic-phantom
#2
Yannick Poirier, Mauro Tambasco
We present an experimental validation of a kilovoltage (kV) X-ray source characterization model in an anthropomorphic phantom to estimate patient-specific absorbed dose from kV cone-beam computed tomography (CBCT) imaging procedures and compare these doses to nominal weighted CT-dose index (CTDIw) dose estimates. We simulated the default Varian on-board imager 1.4 (OBI) default CBCT imaging protocols (i.e., standard-dose head, low-dose thorax, pelvis, and pelvis spotlight) using our previously developed and easy to implement X-ray point-source model and source characterization approach...
July 2016: Journal of Applied Clinical Medical Physics
https://www.readbyqxmd.com/read/28295607/incremental-hemodialysis-the-university-of-california-irvine-experience
#3
Mehrdad Ghahremani-Ghajar, Vanessa Rojas-Bautista, Wei-Ling Lau, Madeleine Pahl, Miguel Hernandez, Anna Jin, Uttam Reddy, Jason Chou, Yoshitsugu Obi, Kamyar Kalantar-Zadeh, Connie M Rhee
Incremental hemodialysis has been examined as a viable hemodialysis regimen for selected end-stage renal disease (ESRD) patients. Preservation of residual kidney function (RKF) has been the driving impetus for this approach given its benefits upon the survival and quality of life of dialysis patients. While clinical practice guidelines recommend an incremental start of dialysis in peritoneal dialysis patients with substantial RKF, there remains little guidance with respect to incremental hemodialysis as an initial renal replacement therapy regimen...
March 14, 2017: Seminars in Dialysis
https://www.readbyqxmd.com/read/28282006/a-nationwide-analysis-of-kidney-autotransplantation
#4
Zhobin Moghadamyeghaneh, Mark H Hanna, Reza Fazlalizadeh, Yoshitsugu Obi, Clarence E Foster, Michael J Stamos, Hirohito Ichii
There are limited data regarding outcomes of patients underwent kidney autotransplantation. This study aims to investigate outcomes of such patients. The nationwide inpatient sample database was used to identify patients underwent kidney autotransplantation during 2002 to 2012. Multivariate analyses using logistic regression were performed to investigate morbidity predictors. A total of 817 patients underwent kidney autotransplantation from 2002 to 2012. The most common indication of surgery was renal artery pathology (22...
February 1, 2017: American Surgeon
https://www.readbyqxmd.com/read/28270497/neopalana-neoadjuvant-palbociclib-a-cyclin-dependent-kinase-4-6-inhibitor-and-anastrozole-for-clinical-stage-2-or-3-estrogen-receptor-positive-breast-cancer
#5
Cynthia X Ma, Feng Gao, Jingqin Luo, Donald W Northfelt, Matthew P Goetz, Andres Forero, Jeremy Hoog, Michael J Naughton, Foluso Ademuyiwa, Rama Suresh, Karen S Anderson, Julie Margenthaler, Rebecca Aft, Timothy J Hobday, Timothy Moynihan, William Gillanders, Amy Cyr, Timothy J Eberlein, Tina Hieken, Helen Krontiras, Zhanfang Guo, Michelle Lee, Nicholas C Spies, Zachary L Skidmore, Obi L Griffith, Malachi Griffith, Shana Thomas, Caroline Bumb, Kiran Vij, Cynthia Huang Bartlett, Maria Koehler, Hussam Al-Kateb, Souzan Sanati, Matthew J Ellis
PURPOSE: Cyclin-dependent kinase (CDK) 4/6 drives cell proliferation in estrogen receptor positive (ER+) breast cancer. This single-arm phase II neoadjuvant trial (NeoPalAna) assessed the anti-proliferative activity of the CDK4/6 inhibitor palbociclib in primary breast cancer as a prelude to adjuvant studies. EXPERIMENTAL DESIGN: Eligible patients with clinical stage II/III ER+/HER2- breast cancer received anastrozole 1mg daily for 4 weeks (cycle 0) (with goserelin if premenopausal), followed by adding palbociclib (125mg daily on days 1-21) on cycle 1 day 1 (C1D1) for four 28-day cycles unless C1D15 Ki67>10%, in which case patients went off study due to inadequately response...
March 7, 2017: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/28270215/characterization-of-occult-hepatitis-b-virus-infection-among-hiv-positive-patients-in-cameroon
#6
George Gachara, Tshifhiwa Magoro, Lufuno Mavhandu, Emmaculate Lum, Helen K Kimbi, Roland N Ndip, Pascal O Bessong
PURPOSE: Occult hepatitis B infection (OBI) among HIV positive patients varies widely in different geographic regions. We undertook a study to determine the prevalence of occult hepatitis B infection among HIV infected individuals visiting a health facility in South West Cameroon and characterized occult HBV strains based on sequence analyses. METHODS: Plasma samples (n = 337), which previously tested negative for hepatitis B surface antigen (HBsAg), were screened for antibodies against hepatitis B core (anti-HBc) and surface (anti-HBs) antigens followed by DNA extraction...
March 8, 2017: AIDS Research and Therapy
https://www.readbyqxmd.com/read/28257135/the-value-of-lacrimal-scintillography-in-the-assessment-of-patients-with-epiphora
#7
O A Vonica, E Obi, Z Sipkova, C Soare, A R Pearson
PurposeTo assess the influence of dacryoscintillography (DSG) on the treatment decision for patients with epiphora and clinically patent non-functioning lacrimal systems.MethodsA retrospective 3-year review. Inclusion: patients having DSG for epiphora with delayed tear clearance, lacrimal system patency on syringing, and no visible external cause for watering. On the basis of regurgitation during syringing, tear ducts were divided into freely patent (FP≤20%) or stenosed. The DSG results were examined for correlation with symptoms and clinical examination, the influence on decision to proceed to dacryocystorhinostomy (DCR), and the ability to predict the surgical outcome...
March 3, 2017: Eye
https://www.readbyqxmd.com/read/28250772/molecular-characteristics-and-antibiotic-resistance-profiles-of-klebsiella-isolates-in-mthatha-eastern-cape-province-south-africa
#8
Sandeep Vasaikar, Larry Obi, Isaac Morobe, Mary Bisi-Johnson
The increase in the incidence of extended-spectrum β-lactamase- (ESBL-) producing Klebsiella species has become a serious problem worldwide, because of their incrimination in antibiotic resistance. The objective of this study is to investigate the resistance genes responsible for ESBL-producing Klebsiella species and carbapenemase-producing Klebsiella (CRE) isolated in Mthatha and to study their epidemiology. A prospective, descriptive study of 202 nonrepetitive samples from patients was obtained from Nelson Mandela Academic Hospital...
2017: International Journal of Microbiology
https://www.readbyqxmd.com/read/28244600/a-mathematical-model-for-estimating-residual-transmission-risk-of-occult-hepatitis-b-virus-infection-with-different-blood-safety-scenarios
#9
Jos Weusten, Harry van Drimmelen, Marion Vermeulen, Nico Lelie
BACKGROUND: If anti-hepatitis B core antibody testing is not mandated blood donors with occult hepatitis B infection (OBI) may transmit hepatitis B virus (HBV) to a recipient in spite of the use of nucleic acid amplification technology (NAT) or pathogen inactivation (PI). STUDY DESIGN AND METHODS: We developed a model to estimate OBI transmission risk based on three components: the probability distribution of the viral load (VL) in a randomly selected OBI donor, the probability that a given VL remains undetected, and the probability that this VL causes infection in the recipient...
February 28, 2017: Transfusion
https://www.readbyqxmd.com/read/28241784/genetic-profiling-for-anaplasma-and-ehrlichia-species-in-ticks-collected-in-the-eastern-cape-province-of-south-africa
#10
Benson C Iweriebor, Elia J Mmbaga, Abiodun Adegborioye, Aboi Igwaran, Larry C Obi, Anthony I Okoh
BACKGROUND: Anaplasma and Ehrlichia are emerging tick-borne pathogens that cause anaplasmosis and ehrlichiosis in humans and other animals worldwide. Infections caused by these pathogens are deadly if left untreated. There has been relatively no systematic survey of these pathogens among ticks in South Africa, thus necessitating this study. The presence of Anaplasma and Ehrlichia species were demonstrated by PCR in ticks collected from domestic ruminants at some selected communities in the Eastern Cape of South Africa...
February 27, 2017: BMC Microbiology
https://www.readbyqxmd.com/read/28236831/us-renal-data-system-2016-annual-data-report-epidemiology-of-kidney-disease-in-the-united-states
#11
EDITORIAL
Rajiv Saran, Bruce Robinson, Kevin C Abbott, Lawrence Y C Agodoa, John Ayanian, Jennifer Bragg-Gresham, Rajesh Balkrishnan, Joline L T Chen, Elizabeth Cope, Paul W Eggers, Daniel Gillen, Debbie Gipson, Susan M Hailpern, Yoshio N Hall, Yun Han, Kevin He, William Herman, Michael Heung, David Hutton, Steven J Jacobsen, Kamyar Kalantar-Zadeh, Csaba P Kovesdy, Yi Li, Yee Lu, Miklos Z Molnar, Hal Morgenstern, Brahmajee Nallamothu, Danh V Nguyen, Ann M O'Hare, Yoshitsugu Obi, Brett Plattner, Ronald Pisoni, Friedrich K Port, Panduranga Rao, Vanessa Ravel, Connie M Rhee, Ankit Sakhuja, Douglas E Schaubel, David T Selewski, John J Sim, Peter Song, Elani Streja, Manjula Kurella Tamura, Francesca Tentori, Sarah White, Kenneth Woodside, Richard A Hirth, Vahakn Shahinian
No abstract text is available yet for this article.
March 2017: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
https://www.readbyqxmd.com/read/28236632/accuracy-of-a-combined-insulin-like-growth-factor-binding-protein-1-interleukin-6-test-premaquick-in-predicting-delivery-in-women-with-threatened-preterm-labor
#12
George Uchenna Eleje, Euzebus Chinonye Ezugwu, Ahizechukwu Chigoziem Eke, Lydia Ijeoma Eleje, Joseph Ifeanyichukwu Ikechebelu, Ifeanyichukwu Uzoma Ezebialu, Chukwudi Celestine Obiora, Betrand Obi Nwosu, Chukwuemeka Okwudili Ezeama, Gerald Okanandu Udigwe, Charles Ikechukwu Okafor, Frank Okechukwu Ezugwu
PURPOSE: To determine values of combinations of interleukin-6 (IL-6)/cervical native insulin-like growth factor-binding protein-1 (IGFBP-1)/total IGFBP-1 (Premaquick©) in predicting spontaneous deliveries and spontaneous exclusive preterm deliveries in women with threatened preterm labor. METHODS: Women with singleton pregnancies between gestation age (GA) of 24 weeks and 36 weeks and 6 days with preterm labor were recruited during a prospective multicenter study...
February 25, 2017: Journal of Perinatal Medicine
https://www.readbyqxmd.com/read/28236303/characterization-of-hepatitis-b-virus-hbv-pres-s-gene-mutations-in-blood-donors-with-occult-hbv-infection-in-the-baoji-area-of-north-china
#13
Hao Liao, Yan Liu, Jianhong Chen, Weiping Ding, Xiaodong Li, Zhihui Xu, Yuan Yang, Rongjuan Chen, Lanlan Si, Xiaoyuan Xu, Jianxun Guo, Dongping Xu
BACKGROUND: Occult hepatitis B virus (HBV) infection (OBI) in blood donors was investigated in the Baoji area of North China, and OBI-related viral mutations in donors were characterized. STUDY DESIGN AND METHODS: In total, 110,843 blood donor samples that were consecutively collected from December 2011 to March 2015 at the Baoji Blood Center were examined. Hepatitis B surface antigen-negative and HBV DNA-positive OBI samples were amplified for sequence analysis of OBI-related mutations in the HBV preS/S region...
February 24, 2017: Transfusion
https://www.readbyqxmd.com/read/28230456/off-label-prescribing-for-children-with-migraines-in-u-s-ambulatory-care-settings
#14
L Leanne Lai, Leroy Koh, Jane Ai-Chen Ho, Alexander Ting, Augustine Obi
BACKGROUND: Migraines, Which Affect About 10% Of School-Age Children In The United States, Can Significantly Impair Quality Of Life. Despite Potential Disability, Many Children Do Not Receive Treatment Or Prophylaxis, Since Medications Specifically Approved For Children Are Significantly Less Than For Adults. There Is Also Controversy Surrounding The Apparent Widespread Practice Of Prescribing Off-Label Medications For Children With Migraines. However, Little Research Has Been Done To Identify Physician-Prescribing Patterns Of Migraine Medication For Children...
March 2017: Journal of Managed Care & Specialty Pharmacy
https://www.readbyqxmd.com/read/28228203/a-nationwide-analysis-of-kidney-autotransplantation
#15
Zhobin Moghadamyeghaneh, Mark H Hanna, Reza Fazlalizadeh, Yoshitsugu Obi, Clarence E Foster, Michael J Stamos, Hirohito Ichii
There are limited data regarding outcomes of patients underwent kidney autotransplantation. This study aims to investigate outcomes of such patients. The nationwide inpatient sample database was used to identify patients underwent kidney autotransplantation during 2002 to 2012. Multivariate analyses using logistic regression were performed to investigate morbidity predictors. A total of 817 patients underwent kidney autotransplantation from 2002 to 2012. The most common indication of surgery was renal artery pathology (22...
February 1, 2017: American Surgeon
https://www.readbyqxmd.com/read/28216353/left-subclavian-artery-revascularization-in-zone-2-thoracic-endovascular-aortic-repair-is-associated-with-lower-stroke-risk-across-all-aortic-diseases
#16
Rhiannon J Bradshaw, S Sadie Ahanchi, Obie Powell, Sebastian Larion, Colin Brandt, Michael C Soult, Jean M Panneton
BACKGROUND: The best management strategy for the left subclavian artery (LSA) in pathologic processes of the aorta requiring zone 2 thoracic endovascular aortic repair (TEVAR) remains controversial. We compared LSA coverage with or without revascularization as well as the different means of LSA revascularization. METHODS: A retrospective chart review was conducted of patients with any aortic diseases who underwent zone 2 TEVAR deployment from 2007 to 2014. Primary end points included 30-day stroke and 30-day spinal cord injury (SCI)...
February 16, 2017: Journal of Vascular Surgery
https://www.readbyqxmd.com/read/28208185/evaluation-of-progressive-visual-dysfunction-and-retinal-degeneration-in-patients-with-parkinson-s-disease
#17
Maria Satue, Maria J Rodrigo, Javier Obis, Elisa Vilades, Hector Gracia, Sofia Otin, Maria I Fuertes, Raquel Alarcia, Jose A Crespo, Vicente Polo, Jose M Larrosa, Luis E Pablo, Elena Garcia-Martin
Purpose: To quantify changes in visual function parameters and in the retinal nerve fiber layer and macular thickness over a 5-year period in patients with Parkinson's disease (PD). Methods: Thirty patients with PD and 30 healthy subjects underwent a complete ophthalmic evaluation, including assessment of visual acuity, contrast sensitivity vision, color vision, and retinal evaluation with spectral-domain optical coherence tomography (SD-OCT). All subjects were reevaluated after 5 years to quantify changes in visual function parameters, the retinal nerve fiber layer, and macular thickness...
February 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28201764/seasonal-variations-in-transition-mortality-and-kidney-transplantation-among-patients-with-end-stage-renal-disease-in-the-usa
#18
Yoshitsugu Obi, Kamyar Kalantar-Zadeh, Elani Streja, Connie M Rhee, Uttam G Reddy, Melissa Soohoo, Yaping Wang, Vanessa Ravel, Amy S You, Jennie Jing, John J Sim, Danh V Nguyen, Daniel L Gillen, Rajiv Saran, Bruce Robinson, Csaba P Kovesdy
No abstract text is available yet for this article.
February 11, 2017: Nephrology, Dialysis, Transplantation
https://www.readbyqxmd.com/read/28201698/transition-of-care-from-pre-dialysis-prelude-to-renal-replacement-therapy-the-blueprints-of-emerging-research-in-advanced-chronic-kidney-disease
#19
Kamyar Kalantar-Zadeh, Csaba P Kovesdy, Elani Streja, Connie M Rhee, Melissa Soohoo, Joline L T Chen, Miklos Z Molnar, Yoshitsugu Obi, Daniel Gillen, Danh V Nguyen, Keith C Norris, John J Sim, Steve S Jacobsen
No abstract text is available yet for this article.
February 11, 2017: Nephrology, Dialysis, Transplantation
https://www.readbyqxmd.com/read/28191016/incidence-and-molecular-characterization-of-hepatitis-e-virus-from-swine-in-eastern-cape-south-africa
#20
Olusesan Adeyemi Adelabu, Benson Chuks Iweriebor, U U Nwodo, Larry Chikwelu Obi, Anthony Ifeanyi Okoh
Hepatitis E virus-mediated infection is a serious public health concern in economically developing nations of the world. Globally, four major genotypes of HEV have been documented. Hepatitis E has been suggested to be zoonotic owing to the increase of evidence through various studies. Thus far, this paper reports on prevalence of hepatitis E virus among swine herd in selected communal and commercial farms in the Eastern Cape Province of South Africa. A total of 160 faecal samples were collected from swine herds in Amathole and Chris Hani District Municipalities of Eastern Cape Province for the presence of HEV...
2017: Advances in Virology
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