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https://www.readbyqxmd.com/read/28444336/intradialytic-hypotension-blood-pressure-changes-and-mortality-risk-in-incident-hemodialysis-patients
#1
Jason A Chou, Elani Streja, Danh V Nguyen, Connie M Rhee, Yoshitsugu Obi, Jula K Inrig, Alpesh Amin, Csaba P Kovesdy, John J Sim, Kamyar Kalantar-Zadeh
Background.: Intradialytic hypotension (IDH) occurs frequently in maintenance hemodialysis (HD) patients and may be associated with higher mortality. We hypothesize that nadir intradialytic systolic blood pressure (niSBP) is inversely related to death risk while iSBP change (Δ) and IDH frequency are incrementally associated with all-cause mortality. Methods.: In a US-based cohort of 112 013 incident HD patients over a 5-year period (2007-11), using niSBP, ΔiSBP (pre-HD SBP minus niSBP) and IDH frequency (proportion of HD treatments with niSBP <90 mmHg) within the first 91 days of HD, we examined mortality-predictability at 1, 2 and 5 years using Cox models and restricted cubic splines adjusted for case-mix, comorbidities and laboratory covariates...
April 21, 2017: Nephrology, Dialysis, Transplantation
https://www.readbyqxmd.com/read/28434888/melorheostosis-exome-sequencing-of-an-associated-dermatosis-implicates-postzygotic-mosaicism-of-mutated-kras
#2
Michael P Whyte, Malachi Griffith, Lee Trani, Steven Mumm, Gary S Gottesman, William H McAlister, Kilannin Krysiak, Robert Lesurf, Zachary L Skidmore, Katie M Campbell, Ilana S Rosman, Susan Bayliss, Vinieth N Bijanki, Angela Nenninger, Brian A Van Tine, Obi L Griffith, Elaine R Mardis
Melorheostosis (MEL) is the rare sporadic dysostosis characterized by monostotic or polyostotic osteosclerosis and hyperostosis often distributed in a sclerotomal pattern. The prevailing hypothesis for MEL invokes postzygotic mosaicism. Sometimes scleroderma-like skin changes, considered a representation of the pathogenetic process of MEL, overlie the bony changes, and sometimes MEL becomes malignant. Osteopoikilosis (OPK) is the autosomal dominant skeletal dysplasia that features symmetrically distributed punctate osteosclerosis due to heterozygous loss-of-function mutation within LEMD3...
April 20, 2017: Bone
https://www.readbyqxmd.com/read/28428474/evaluation-of-absorbed-dose-for-cbct-in-image-guided-radiation-therapy-comparison-of-each-devices-and-facilities
#3
Yumiko Kitazato, Noriyuki Kuga, Katsutoshi Shirieda, Masahiro Enzaki, Yuji Nakaguchi, Yoshinobu Shimohigashi, Toshihisa Kawasaki, Masahiko Toyoda, Daisuke Kawahara, Fujio Araki, Shinji Kawamura
Recently, intensity-modulated radiation therapy (IMRT) is used worldwide, highly accurate verification of the location using image-guided radiation therapy (IGRT) has become critical. However, the use of cone-beam computed tomography (CBCT) to ascertain the location each time raises concerns about its influence on radiotherapy dosage and increased radiation exposure. The purpose of this study was to measure the absorbed dose using nine kilovoltage (kV) devices and two megavoltage (MV) devices (total 11 devices) at eight facilities, compare the absorbed dose among the devices, and assess the characteristics of the respective devices to ensure optimal clinical operation...
2017: Nihon Hoshasen Gijutsu Gakkai Zasshi
https://www.readbyqxmd.com/read/28422393/accuracy-and-response-time-of-dual-biomarker-model-of-insulin-like-growth-factor-binding-protein-1-alpha-fetoprotein-amnioquick-duo-in-comparison-to-placental-alpha-microglobulin-1-test-in-diagnosis-of-premature-rupture-of-membranes
#4
George Uchenna Eleje, Euzebus Chinonye Ezugwu, Ahizechukwu Chigoziem Eke, Joseph Ifeanyichukwu Ikechebelu, Chukwuemeka Okwudili Ezeama, Ifeanyichukwu Uzoma Ezebialu, Nnabuike Okechukwu Ojiegbe, Chukwudi Celestine Obiora, Charles Ikechukwu Okafor, Gerald Okanandu Udigwe, Betrand Obi Nwosu, Frank O Ezugwu
AIM: The aim of this study was to determine accuracy and response time of duo of insulin-like growth factor binding protein-1 (IGFBP-1)/alpha-fetoprotein (Amnioquick duo+) versus placental alpha-microglobulin-1 (PAMG-1) in diagnosing premature rupture of membranes (PROM). METHODS: A multicenter prospective study was conducted among women with features suggestive of PROM between 24 and 42 gestational weeks (GW). PROM was confirmed post-delivery based on presence of any two of these criteria: delivery within 48 h to 7 days, chorioamnionitis, membranes overtly ruptured at delivery, and adverse perinatal outcomes strongly correlated with prolonged PROM...
April 19, 2017: Journal of Obstetrics and Gynaecology Research
https://www.readbyqxmd.com/read/28421638/renal-replacement-therapy-and-incremental-hemodialysis-for-veterans-with-advanced-chronic-kidney-disease
#5
Kamyar Kalantar-Zadeh, Susan T Crowley, Srinivasan Beddhu, Joline L T Chen, John T Daugirdas, David S Goldfarb, Anna Jin, Csaba P Kovesdy, David J Leehey, Hamid Moradi, Sankar D Navaneethan, Keith C Norris, Yoshitsugu Obi, Ann O'Hare, Tariq Shafi, Elani Streja, Mark L Unruh, Tushar J Vachharajani, Steven Weisbord, Connie M Rhee
Each year approximately 13,000 Veterans transition to maintenance dialysis, mostly in the traditional form of thrice-weekly hemodialysis from the start. Among >6000 dialysis units nationwide, there are currently approximately 70 Veterans Affairs (VA) dialysis centers. Given this number of VA dialysis centers and their limited capacity, only 10% of all incident dialysis Veterans initiate treatment in a VA center. Evidence suggests that, among Veterans, the receipt of care within the VA system is associated with favorable outcomes, potentially because of the enhanced access to healthcare resources...
April 18, 2017: Seminars in Dialysis
https://www.readbyqxmd.com/read/28419850/overpressure-blast-injury-induced-oxidative-stress-and-neuroinflammation-response-in-rat-frontal-cortex-and-cerebellum
#6
Hale Z Toklu, Zhihui Yang, Sehkar Oktay, Yasemin Sakarya, Nataliya Kirichenko, Michael K Matheny, Judy Muller-Delp, Kevin Strang, Philip J Scarpace, Kevin K W Wang, Nihal Tümer
BACKGROUND & AIM: Overpressure blast-wave induced brain injury (OBI) and its long-term neurological outcome pose significant concerns for military personnel. Our aim is to investigate the mechanism of injury due to OBI. METHODS: Rats were divided into 3 groups: 1) Control, 2) OBI (exposed 30psi peak pressure, 2-2.5ms), 3) Repeated OBI (r-OBI) (three exposures over one-week period). Lung and brain (cortex and cerebellum) tissues were collected at 24h post injury...
April 15, 2017: Behavioural Brain Research
https://www.readbyqxmd.com/read/28411716/pathophysiology-of-varicose-veins
#7
Benjamin N Jacobs, Elizabeth A Andraska, Andrea T Obi, Thomas W Wakefield
BACKGROUND: Varicose veins, a common problem with effects on quality of life, account for a significant cost burden on the health care system. Despite their prevalence, the pathophysiologic mechanism of varicose veins remains incompletely understood. The fundamental issue is whether venous hypertension and valvular incompetence precede and influence the development of vein wall changes or whether the reverse is true. METHODS: We have reviewed the English-language literature to provide the most current understanding of the hemodynamic and cellular and molecular processes that underlie the development of varicose veins...
May 2017: Journal of Vascular Surgery. Venous and Lymphatic Disorders
https://www.readbyqxmd.com/read/28411696/first-10-month-results-of-the-vascular-quality-initiative-varicose-vein-registry
#8
Andrea T Obi, Danielle C Sutzko, Jose I Almeida, Lowell Kabnick, Jack L Cronenwett, Nicholas H Osborne, Brajesh K Lal, Thomas W Wakefield
OBJECTIVE: The Vascular Quality Initiative Varicose Vein Registry (VQI VVR) represents a new Patient Safety Organization database launched in January 2015 as a collaborative effort between the American Venous Forum and the Society for Vascular Surgery. This study was undertaken to identify real-world trends among treatment choices and outcomes of varicose vein patients. METHODS: Registry data prospectively captured anatomic, procedural, and outcome data for patients with C2 or more severe disease undergoing intervention for venous varicosities from January to November 2015...
May 2017: Journal of Vascular Surgery. Venous and Lymphatic Disorders
https://www.readbyqxmd.com/read/28411075/effect-of-gender-and-adiposity-on-in%C3%A2-vivo-vascular-function-in-young-african-americans
#9
Namrata Dass, Sindhu Kilakkathi, Brittaney Obi, Andrea Moosreiner, Shanthi Krishnaswami, Michael E Widlansky, Srividya Kidambi
The relationship between obesity and high blood pressure is not as strong among African Americans (AA) as compared to Caucasians. We designed the current study to determine the effect of adiposity on vascular endothelial function (a harbinger of hypertension) among young healthy AA without additional cardiovascular disease risk factors. A total of 108 AA subjects (46 women) between the ages of 18 and 45 years were recruited. All the subjects were normotensive, nonsmokers, and normoglycemic. Anthropometric and cardiovascular disease risk factor measurements (lipid, insulin resistance, and inflammatory markers) were obtained...
March 14, 2017: Journal of the American Society of Hypertension: JASH
https://www.readbyqxmd.com/read/28401424/hospital-acquired-conditions-are-associated-with-worse-outcomes-in-crohn-s-disease-related-hospitalizations
#10
Kenneth Obi, Alice Hinton, Lindsay Sobotka, Edward Levine, Darwin Conwell, Cheng Zhang
BACKGROUND: Crohn's disease (CD) is a chronically relapsing condition that frequently requires hospitalization. In 2008, the Centers for Medicare and Medicaid Services selected ten conditions that were deemed healthcare-acquired conditions (HACs). Costs related to HACs are not reimbursed as they are considered to be preventable. AIM: To determine the prevalence and impact of HACs on hospital outcomes of hospitalized CD patients. METHODS: This was a cross-sectional study using data from the Nationwide Inpatient Sample between 2007 and 2011 with an extended time frame between 2002 and 2013 to specifically evaluate the prevalence of HACs...
April 11, 2017: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/28389595/cancer-immunogenomics-computational-neoantigen-identification-and-vaccine-design
#11
Jasreet Hundal, Christopher A Miller, Malachi Griffith, Obi L Griffith, Jason Walker, Susanna Kiwala, Aaron Graubert, Joshua McMichael, Adam Coffman, Elaine R Mardis
The application of modern high-throughput genomics to the study of cancer genomes has exploded in the past few years, yielding unanticipated insights into the myriad and complex combinations of genomic alterations that lead to the development of cancers. Coincident with these genomic approaches have been computational analyses that are capable of multiplex evaluations of genomic data toward specific therapeutic end points. One such approach is called "immunogenomics" and is now being developed to interpret protein-altering changes in cancer cells in the context of predicted preferential binding of these altered peptides by the patient's immune molecules, specifically human leukocyte antigen (HLA) class I and II proteins...
April 7, 2017: Cold Spring Harbor Symposia on Quantitative Biology
https://www.readbyqxmd.com/read/28386278/global-status-of-porcine-circovirus-type-2-and-its-associated-diseases-in-sub-saharan-africa
#12
REVIEW
Kayode O Afolabi, Benson C Iweriebor, Anthony I Okoh, Larry C Obi
Globally, Porcine circovirus type 2 (PCV2) is a recognized viral pathogen of great economic value in pig farming. It is the major cause of ravaging postweaning multisystemic wasting syndrome (PMWS) and many other disease syndromes generally regarded as Porcine circovirus associated diseases (PCVAD) in Europe. PCV2 infections, specifically PMWS, had impacted huge economic loss on swine production at different regions of the world. It has been studied and reported at different parts of the globe including: North and South America, Europe, Asia, Oceania, Middle East, and the Caribbean...
2017: Advances in Virology
https://www.readbyqxmd.com/read/28381700/occult-hepatitis-b-virus-infection-in-hyperlipidemia-patients
#13
Liu Yang, Tingting Li, Wenmin Li, Xi Tang, Jinfeng Li, Ruiwen Long, Yongshui Fu, Jean-Pierre Allain, Chengyao Li
Chronic hepatitis B virus (HBV) infection is associated with lower prevalence of hyperlipidemia (HLP). However, occult HBV infection (OBI) in HLP patients has not yet been explored. OBI is defined as the presence of detectable HBV DNA in serum or liver tissue but undetectable HBV surface antigen in serum. In this study, 1,036 HLP patients and 1,134 replacement blood donor controls were recruited. Among them, 252 HLP patients and 255 blood donors with antibody to HBV core positive were selected and analyzed...
April 2017: Tohoku Journal of Experimental Medicine
https://www.readbyqxmd.com/read/28371867/erratum
#14
Yoshitsugu Obi, Kamyar Kalantar-Zadeh, Elani Streja, Connie M Rhee, Uttam G Reddy, Melissa Soohoo, Yaping Wang, Vanessa Ravel, Amy S You, Jennie Jing, John J Sim, Danh V Nguyen, Daniel L Gillen, Rajiv Saran, Bruce Robinson, Csaba P Kovesdy
No abstract text is available yet for this article.
March 20, 2017: Nephrology, Dialysis, Transplantation
https://www.readbyqxmd.com/read/28342241/overt-and-occult-hepatitis-b-virus-infection-among-community-children-in-northwest-china
#15
H Su, Z Shao, Z Pu, Y Wang, L Zhang, W Zhang, B Wang, A Wang, Z Ji, Y Yan, Y Zhang
Although a universal newborn hepatitis B (HB) immunization programme has been implemented in China, hepatitis B virus (HBV) breakthrough infection, including HB surface antigen (HBsAg)-positive infection and occult HBV infection (OBI), still occurs during infancy or childhood. Obtaining the actual prevalence of HBV infection in general children is important for preventing and controlling the spread of HB. Accordingly, we investigated the prevalence of overt infection and OBI in community children and compared the serological and virological characteristics of OBI and HBsAg carrier children to clarify the mechanisms related to OBI...
March 25, 2017: Journal of Viral Hepatitis
https://www.readbyqxmd.com/read/28340192/prediction-equation-for-calculating-residual-kidney-urea-clearance-using-urine-collections-for-different-hemodialysis-treatment-frequencies-and-interdialytic-intervals
#16
Yoshitsugu Obi, Kamyar Kalantar-Zadeh, Elani Streja, John T Daugirdas
Background.: The purpose of the study was to explore the precision of an equation designed to estimate residual kidney urea clearance (K RU ) from interdialytic urine collection data and pre-hemodialysis (HD) serum urea nitrogen (SUN) in different hemodialysis treatment schedules. Methods.: The generalizability of the proposed equation was tested in 32 731 HD treatments where urine was collected prior to a dialysis session, mostly for 24 h but sometimes longer, in patients being dialyzed 1-4 times/week...
March 15, 2017: Nephrology, Dialysis, Transplantation
https://www.readbyqxmd.com/read/28340135/modeling-longitudinal-data-and-its-impact-on-survival-in-observational-nephrology-studies-tools-and-considerations
#17
Elani Streja, Leanne Goldstein, Melissa Soohoo, Yoshitsugu Obi, Kamyar Kalantar-Zadeh, Connie M Rhee
Nephrologists and kidney disease researchers are often interested in monitoring how patients' clinical and laboratory measures change over time, what factors may impact these changes, and how these changes may lead to differences in morbidity, mortality, and other outcomes. When longitudinal data with repeated measures over time in the same patients are available, there are a number of analytical approaches that could be employed to describe the trends and changes in these measures, and to explore the associations of these changes with outcomes...
April 1, 2017: Nephrology, Dialysis, Transplantation
https://www.readbyqxmd.com/read/28335077/introduction-to-the-critical-balance-residual-kidney-function-and-incremental-transition-to-dialysis
#18
Yoshitsugu Obi, Jason Chou, Kamyar Kalantar-Zadeh
No abstract text is available yet for this article.
March 23, 2017: Seminars in Dialysis
https://www.readbyqxmd.com/read/28332342/evaluation-of-the-truebeam-machine-performance-check-mpc-geometric-checks-for-daily-igrt-geometric-accuracy-quality-assurance
#19
Michael P Barnes, Peter B Greer
Machine Performance Check (MPC) is an automated and integrated image-based tool for verification of beam and geometric performance of the TrueBeam linac. The aims of the study were to evaluate the performance of the MPC geometric tests relevant to OBI/CBCT IGRT geometric accuracy. This included evaluation of the MPC isocenter and couch tests. Evaluation was performed by comparing MPC to QA tests performed routinely in the department over a 4-month period. The MPC isocenter tests were compared against an in-house developed Winston-Lutz test and the couch compared against routine mechanical QA type procedures...
March 22, 2017: Journal of Applied Clinical Medical Physics
https://www.readbyqxmd.com/read/28327123/evaluating-the-sub-national-fidelity-of-national-initiatives-in-decentralized-health-systems-integrated-primary-health-care-governance-in-nigeria
#20
Ejemai Amaize Eboreime, Seye Abimbola, Felix Abrahams Obi, Obinna Ebirim, Olalekan Olubajo, John Eyles, Nonhlanhla Lynette Nxumalo, Faith Nankasa Mambulu
BACKGROUND: Policy making, translation and implementation in politically and administratively decentralized systems can be challenging. Beyond the mere sub-national acceptance of national initiatives, adherence to policy implementation processes is often poor, particularly in low and middle-income countries. In this study, we explore the implementation fidelity of integrated PHC governance policy in Nigeria's decentralized governance system and its implications on closing implementation gaps with respect to other top-down health policies and initiatives...
March 21, 2017: BMC Health Services Research
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