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https://www.readbyqxmd.com/read/29132329/determinants-of-patterns-of-maternal-and-child-health-service-utilization-in-a-rural-community-in-south-eastern-nigeria
#1
C C Agunwa, I E Obi, A C Ndu, I B Omotowo, C A Idoko, A K Umeobieri, E C Aniwada
BACKGROUND: Women and children constitute a large proportion of any population. They are the most vulnerable to morbidity and mortality especially in developing countries. In many situations the problem of poor maternal and child health stems from the poor use of available services even when they are not of optimum quality. This study seeks to describe the patterns of utilization of Maternal and Child health (MCH) services in a rural area of Enugu State, and identify factors that are associated with and responsible for determining them...
November 13, 2017: BMC Health Services Research
https://www.readbyqxmd.com/read/29131932/redox-dependent-metal-metal-bonding-in-trinuclear-metal-chains-probing-the-transition-from-covalent-bonding-to-exchange-coupling
#2
John Ewart McGrady, Nicholas Perkins, Mohammed Obies, Graham Heath, Alison Edwards, Vaida Arcisauskaite
We report here the synthesis and physical properties of two new cationic tri-metallic chains, [(PEt3)3RuCl3M'Cl3Ru(PEt3)3]1+, M' = Rh and Ir. These are isostructural with a previously reported 17-electron all-ruthenium analogue, but the switch from an open-shell d5 Ru3+ ion to d6 Rh3+/Ir3+ in the central position has profound impact on the nature of the metal-metal bonding. X-ray crystallography and spectro-electrochemistry, complemented by electronic structure analysis at the DFT and CASSCF levels, indicate that whilst the presence of a Ru3+ ion in the center of the chain allows multi-center covalent bonding to develop, a closed-shell Rh3+/Ir3+ ion pushes the system towards the exchange-coupled limit, where the terminal Ru centers are only weakly interacting...
November 13, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/29130984/lymphocyte-cell-ratios-and-mortality-among-incident-hemodialysis-patients
#3
Christina Catabay, Yoshitsugu Obi, Elani Streja, Melissa Soohoo, Christina Park, Connie M Rhee, Csaba P Kovesdy, Takayuki Hamano, Kamyar Kalantar-Zadeh
BACKGROUND: Neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) have been previously suggested as oncologic prognostication markers. These are associated with malnutrition and inflammation, and hence, may provide benefit in predicting mortality among hemodialysis patients. METHODS: Among 108,548 incident hemodialysis patients in a large U.S. dialysis organization (2007-2011), we compared the mortality predictability of NLR and PLR with baseline and time-varying covariate Cox models using the receiver operating characteristic curve (AUROC), net reclassification index (NRI), and adjusted R2...
November 7, 2017: American Journal of Nephrology
https://www.readbyqxmd.com/read/29120585/prevalence-of-occult-hbv-infection-among-chronic-hepatitis-c-patients-in-upper-egypt
#4
Amany G Thabit, Mona A Hassan, Michael N Agban, Nahed A Makhlouf, Nasr K Khalil, Hebat-Allah M Hassan, Mohamed A El-Mokhtar
Occult hepatitis B virusinfection (OBI) is defined as the presence of HBV DNA in liver or serum of individuals who test negative for hepatitis B surface antigen (HBsAg).We aimed at determining the prevalence of OBI in patients chronically infected with HCV in Upper Egypt and to evaluate the possible impact of OBI on the progression of the liver disease. This study included 200 chronic HCV infected patients. HBV DNA was detected in the serum of 21 patients (10.5%) by nested PCR. 13 of them were positive for anti-HBc...
January 2017: Egyptian Journal of Immunology
https://www.readbyqxmd.com/read/29120576/serological-and-molecular-diagnosis-of-occult-hepatitis-b-virus-infection-in-hepatitis-c-chronic-liver-diseases
#5
Enas A Daef, Nahed A Makhlouf, Entsar H Ahmed, Ahmed I Mohamed, Mohamed H Abd El Aziz, Mohamed A El-Mokhtar
Occult Hepatitis B infection (OBI), defined as the presence of serum HBV DNA without detectable HBsAg, can be classified into seropositive OBI [anti-HBc and/or anti-hepatitis B surface (anti- HBs) positive] and seronegative OBI (anti-HBc and anti- HBs negative). We examined the role of anti-HBc as a screening test for OBI in HCV patients with chronic liver diseases and evaluated the possible impact of OBI on liver disease progression. 90 patients with hepatitis C related chronic liver diseases (CLD) and negative for HBsAg were divided into three equal groups; chronic hepatitis, liver cirrhosis and hepatocellular carcinoma (HCC)...
January 2017: Egyptian Journal of Immunology
https://www.readbyqxmd.com/read/29111842/retinal-and-choroidal-changes-in-patients-with-parkinson-s-disease-detected-by-swept-source-optical-coherence-tomography
#6
Maria Satue, Javier Obis, Raquel Alarcia, Elvira Orduna, Maria J Rodrigo, Elisa Vilades, Hector Gracia, Sofia Otin, Maria I Fuertes, Vicente Polo, Jose M Larrosa, Luis E Pablo, Elena Garcia-Martin
PURPOSE: To evaluate the ability of new Swept source (SS) optical coherence tomography (OCT) technology to detect changes in retinal and choroidal thickness in patients with Parkinson's disease (PD). DESIGN: Observational case-control cross sectional study, developed from January to May 2016. METHODS: In total, 50 eyes from 50 patients diagnosed with PD and 54 eyes of 54 healthy controls underwent retinal and choroidal assessment using SS DRI Triton OCT (Topcon), using the 3D Wide protocol...
November 7, 2017: Current Eye Research
https://www.readbyqxmd.com/read/29109370/olive-olea-europaea-l-biophenols-a-nutriceutical-against-oxidative-stress-in-sh-sy5y-cells
#7
Syed Haris Omar, Philip G Kerr, Christopher J Scott, Adam S Hamlin, Hassan K Obied
Plant biophenols have been shown to be effective in the modulation of Alzheimer's disease (AD) pathology resulting from free radical-induced oxidative stress and imbalance of the redox chemistry of transition metal ions (e.g., iron and copper). On the basis of earlier reported pharmacological activities, olive biophenols would also be expected to have anti-Alzheimer's activity. In the present study, the antioxidant activity of individual olive biophenols (viz. caffeic acid, hydroxytyrosol, oleuropein, verbascoside, quercetin, rutin and luteolin) were evaluated using superoxide radical scavenging activity (SOR), hydrogen peroxide (H₂O₂) scavenging activity, and ferric reducing ability of plasma (FRAP) assays...
October 29, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29102862/reno-portal-shunt-for-liver-transplant-an-alternative-inflow-for-recipients-with-grade-iii-iv-portal-vein-thrombosis-tips-for-a-better-outcome
#8
Mustafa Nazzal, Yifei Sun, Obi Okoye, Laurence Diggs, Neil Evans, Tamara Osborn, Kambiz Etesami, Chintalapati Varma
INTRODUCTION: Portal vein thrombosis (PVT) poses an extremely difficult problem in cirrhotic patients who are in need of a liver transplant. The prevalence of PVT in patients with cirrhosis ranges from 0.6% to 26% Nery et al. (2015) [1]. The presence of PVT is associated with more technically difficult liver transplant and in certain cases can be a contraindication to liver transplant. The only option for these patients with extensive PVT would be a multi-visceral transplant, the later unfortunately has a much higher morbidity and mortality compared to liver only transplant Smith et al...
October 12, 2017: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/29099345/coagulation-management-during-liver-transplantation-use-of-fibrinogen-concentrate-recombinant-activated-factor-vii-prothrombin-complex-concentrate-and-antifibrinolytics
#9
Jonathan H Chow, Khang Lee, Ezeldeen Abuelkasem, Obi R Udekwu, Kenichi A Tanaka
Coagulation management, and transfusion practice in liver transplantation (LT) have been evolving in the recent years due to better understanding of coagulation abnormalities in end-stage liver disease, and clinical management of LT patients. Avoidance of allogeneic blood components is feasible in some patients, but multi-modal coagulation therapies may be necessary in others who develop complex coagulopathy due to hemorrhage, hemodilution, hypothermia, and acid-base disturbances. Transfusions of plasma and cryoprecipitate remain to be the mainstay therapy for procoagulant factor replacement during LT...
November 1, 2017: Seminars in Cardiothoracic and Vascular Anesthesia
https://www.readbyqxmd.com/read/29096613/molecular-detection-of-porcine-circovirus-type-2-in-swine-herds-of-eastern-cape-province-south-africa
#10
Kayode Olayinka Afolabi, Benson Chuks Iweriebor, Larry Chikwelu Obi, Anthony Ifeanyi Okoh
BACKGROUND: Porcine circovirus type 2 (PCV2) remains the main causative viral pathogen of porcine circovirus-associated diseases (PCVAD) of great economic importance in pig industry globally. This present study aims at determining the occurrence of the viral pathogen in swine herds of the Province. RESULTS: The data obtained revealed that 15.93% of the screened samples (54/339) from the swine herds of the studied areas were positive for PCV2; while the severity of occurrence of the viral pathogen as observed at farm level ranges from approximately 5...
November 2, 2017: BMC Microbiology
https://www.readbyqxmd.com/read/29079503/role-of-dopamine-on-functional-recovery-in-the-contralateral-hemisphere-after-focal-stroke-in-the-somatosensory-cortex
#11
Kisho Obi, Izuki Amano, Yusuke Takatsuru
Functional recovery after a stroke is important for patients' quality of life. Not only medical care during the acute phase, but also rehabilitation during the chronic phase after a stroke is important. However, the mechanisms underlying functional recovery, particularly the chronic phase after stroke, are still not fully understood. Thus, further basic study on brain after focal stroke is necessary. In this study, we found that the concentration of dopamine (DA) increased during first week after a stroke in the hemisphere contralateral in the site of stroke by in vivo microdialysis...
October 24, 2017: Brain Research
https://www.readbyqxmd.com/read/29074501/single-agent-ibrutinib-in-relapsed-or-refractory-follicular-lymphoma-a-phase-2-consortium-trial
#12
Nancy L Bartlett, Brian A Costello, Betsy R LaPlant, Stephen M Ansell, John G Kuruvilla, Craig B Reeder, Lim S Thye, Daniel M Anderson, Kilannin Krysiak, Cody Ramirez, Jing Qi, Barry A Siegel, Malachi Griffith, Obi L Griffith, Felicia Gomez, Todd A Fehniger
Most patients with follicular lymphoma experience multiple relapses necessitating subsequent lines of therapy. Ibrutinib, a Bruton tyrosine kinase inhibitor approved for the treatment of several B-cell malignancies, showed promising activity in follicular lymphoma in a Phase 1 study. We report the results of a Phase 2 trial evaluating ibrutinib in recurrent follicular lymphoma. Forty patients with recurrent follicular lymphoma were treated with ibrutinib, 560 mg/day until progression or intolerance. The primary endpoint was overall response rate...
October 26, 2017: Blood
https://www.readbyqxmd.com/read/29062862/high-rates-of-occult-hepatitis-b-virus-infection-in-hiv-positive-individuals-initiating-antiretroviral-therapy-in-botswana
#13
Kathleen Ryan, Motswedi Anderson, Ivayla Gyurova, Lilliam Ambroggio, Sikhulile Moyo, Teresa Sebunya, Joseph Makhema, Richard Marlink, Max Essex, Rosemary Musonda, Simani Gaseitsiwe, Jason T Blackard
BACKGROUND: Hepatitis B surface antigen (HBsAg)-negative but hepatitis B virus (HBV) DNA-positive infection-known as occult hepatitis B infection (OBI)-occurs in 1% to >15% of HIV-positive individuals in the United States and South Africa, respectively. However, there are no data on OBI from Botswana, a country known to be hyperendemic for chronic HBV infection and to have a significant HIV burden. METHODS: Two hundred seventy-two adults enrolled in an HIV treatment study of tenofovir/emtricitabine as the nucleoside backbone who were previously determined to be HBsAg negative were tested for HBV DNA at baseline and 1 year after initiation of highly active antiretroviral therapy (HAART)...
2017: Open Forum Infectious Diseases
https://www.readbyqxmd.com/read/29061159/genetic-polymorphisms-of-hla-dp-and-isolated-anti-hbc-are-important-subsets-of-occult-hepatitis-b-infection-in-indonesian-blood-donors-a-case-control-study
#14
Yan Mardian, Yoshihiko Yano, Widya Wasityastuti, Neneng Ratnasari, Yujiao Liang, Wahyu Aristyaning Putri, Teguh Triyono, Yoshitake Hayashi
BACKGROUND: Occult hepatitis B infection (OBI) is defined as the presence of hepatitis B virus (HBV) DNA in the serum and/or liver in HBsAg-negative individuals. OBI is associated with the risk of viral transmission, especially in developing countries, and with progressive liver disease and reactivation in immunosuppressive patients. The objective of this study was to evaluate the relation of OBI to HLA-DP single nucleotide polymorphisms (SNPs) encoding antigen-binding sites for the immune response to HBV infection...
October 23, 2017: Virology Journal
https://www.readbyqxmd.com/read/29056449/venous-disease-patient-registries-available-in-the-united-states
#15
Fedor Lurie, Andrea Obi, Marlin Schul, Lawrence V Hofmann, Gregory Kasper, Thomas Wakefield
Patient registries are beneficial in that they allow the collection of prospective data focused on a specific medical issue. These registries give providers a "real-world" view of patient outcomes. Many medical disciplines have a long history of developing and using patient registries; the first patient registry for chronic venous disease in the United States was launched in 2011, fairly recently in comparison. Registries included in this review were identified by surveying members of major academic societies that focus on the care of chronic venous disease and by searching MEDLINE and Embase databases using Ovid interface...
October 19, 2017: Journal of Vascular Surgery. Venous and Lymphatic Disorders
https://www.readbyqxmd.com/read/29051804/review-of-recombinant-anti-haemophilic-porcine-sequence-factor-viii-in-adults-with-acquired-haemophilia-a
#16
REVIEW
Emma Fosbury, Anja Drebes, Anne Riddell, Pratima Chowdary
Acquired haemophilia A (AHA) is a rare, serious bleeding disorder most often encountered in elderly patients. The mainstay of haemostatic management is with bypassing agents (BPAs) including recombinant activated factor VII (rFVIIa) and activated prothrombin complex concentrates (aPCCs). Their major limitation is incomplete efficacy, potential risk for thrombosis and the lack of routine laboratory assays for monitoring treatment response. Plasma-derived porcine FVIII (pd-pFVIII, Hyate C(®)), first used in the 1950s for the management of congenital haemophilia, has sufficient sequence homology to be haemostatic in humans, but the lack of complete homology facilitates efficacy even in the presence of human allo- and autoantibodies against human FVIII (hFVIII)...
September 2017: Therapeutic Advances in Hematology
https://www.readbyqxmd.com/read/29044764/estimated-glomerular-filtration-rate-and-the-risk-benefit-profile-of-intensive-blood-pressure-control-among-non-diabetic-patients-a-post-hoc-analysis-of-a-randomized-clinical-trial
#17
Yoshitsugu Obi, Kamyar Kalantar-Zadeh, Ayumi Shintani, Csaba P Kovesdy, Takayuki Hamano
BACKGROUND: The Systolic Blood Pressure Intervention Trial (SPRINT; ClinicalTrials. gov, NCT01206062) reported reduced cardiovascular events by intensive blood pressure (BP) control among hypertensive patients without diabetes. However, the risk-benefit profile of intensive BP control may differ across estimated glomerular filtration rate (eGFR) levels. METHODS: This is a post-hoc analysis of the SPRINT. Non-diabetic hypertensive adults (n=9,361) with eGFR >20 mL/min/1...
October 16, 2017: Journal of Internal Medicine
https://www.readbyqxmd.com/read/29041763/novel-obi-noise-reduction-technique-by-using-similar-obi-estimation-in-optical-multiple-access-uplink
#18
Hyoung Joon Park, Sun-Young Jung, Sang-Kook Han
A novel optical beat interference (OBI) noise reduction technique for optical multiple access uplink using the same wavelength is presented. The OBI noise is estimated by similar-OBI and mitigated by subtracting estimated OBI noise using the digital signal processing technique. To derive similar-OBI, an RF clipping tone is transmitted out of signal band. We numerically and experimentally verified the validity of proposed OBI noise reduction method in orthogonal frequency division multiplexing access (OFDMA) passive optical network (PON) uplink where the OBI noise has been reduced and signal to noise ratio (SNR) has been improved from 4...
August 21, 2017: Optics Express
https://www.readbyqxmd.com/read/29032635/prevalence-and-natural-course-of-occult-hepatitis-b-virus-infection-in-residents-of-two-communities-of-wuwei-city-gansu-province-china
#19
Xiaohui Wen, Haixia Su, Yang Wang, Zhongshu Pu, Jie Gao, Zhaohua Ji, Xiaojie Yuan, Xiaochun Li, Weilu Zhang, Lei Zhang, Yong Long, Yongping Yan, Zhongjun Shao
Occult hepatitis B infection (OBI) is characterized by serum hepatitis B surface antigen (HBsAg) negative and hepatitis B virus (HBV) DNA positive (HBsAg-/HBV DNA+). OBI in community-based populations has been scarcely investigated, and OBI outcomes remain unclear, especially in Wuwei, a region located in Northwest China. This region is one of the areas in China that has the highest prevalence of chronic HBV infection. A prospective study was performed in the general population of two towns of Wuwei from June 2011 to May 2014...
October 15, 2017: Journal of Viral Hepatitis
https://www.readbyqxmd.com/read/29020035/correction-decoupling-of-the-pi3k-pathway-via-mutation-necessitates-combinatorial-treatment-in-her2-breast-cancer
#20
James E Korkola, Eric A Collisson, Laura M Heiser, Chris Oates, Nora Bayani, Sleiman Itani, Amanda Esch, Wallace Thompson, Obi L Griffith, Nicholas J Wang, Wen-Lin Kuo, Brian Cooper, Jessica Billig, Safiyyah Ziyad, Jenny L Hung, Lakshmi Jakkula, Heidi Feiler, Yiling Lu, Gordon B Mills, Paul T Spellman, Claire Tomlin, Sach Mukherjee, Joe W Gray
[This corrects the article DOI: 10.1371/journal.pone.0133219.].
2017: PloS One
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