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https://www.readbyqxmd.com/read/28095996/antenatal-predictors-of-outcome-in-prenatally-diagnosed-congenital-diaphragmatic-hernia-cdh
#1
REVIEW
Titilayo Oluyomi-Obi, Verena Kuret, Pramod Puligandla, Abhay Lodha, Helen Lee-Robertson, Kovid Lee, David Somerset, Joann Johnson, Greg Ryan
BACKGROUND: Pulmonary hypoplasia is the main cause of mortality in isolated congenital diaphragmatic hernia (CDH) and its prediction is paramount when counseling parents. We sought to identify antenatal parameters that predicted neonatal mortality in CDH. METHOD: Search was conducted in MEDLINE, EMBASE, Cochrane Database of Systematic reviews, PubMed, Scopus, and Web of Science on the ability of lung-to-head ratio (LHR), observed-to-expected LHR (o/e LHR), total fetal lung volume (TFLV), o/e TFLV, percentage predicted lung volume (PPLV) and degree of liver herniation to predict neonatal morbidity and mortality in fetuses with CDH...
December 21, 2016: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/28090764/incremental-and-infrequent-hemodialysis-a-new-paradigm-for-both-dialysis-initiation-and-conservative-management
#2
Connie M Rhee, Mehrdad Ghahremani-Ghajar, Yoshitsugu Obi, Kamyar Kalantar-Zadeh
Registry or national dialysis data show that a sizeable proportion of contemporary dialysis patients have substantial levels of residual kidney function especially upon transitioning to dialysis therapy. However, among incident hemodialysis patients, the prevailing paradigm has been to initiate "full-dose" thrice-weekly treatment schedules irrespective of native kidney function in most developed countries. Recognizing the benefits of residual kidney function upon the health and survival of dialysis patients, there has been growing interest in incremental hemodialysis, in which dialysis frequency and dose are tailored according to the degree of patients' residual kidney function...
January 13, 2017: Panminerva Medica
https://www.readbyqxmd.com/read/28070599/organophosphate-neurotoxicity-to-the-voluntary-motor-system-on-the-trail-of-environment-caused-amyotrophic-lateral-sclerosis-the-known-the-misknown-and-the-unknown
#3
Samantha J Merwin, Teresa Obis, Yanelli Nunez, Diane B Re
Amyotrophic lateral sclerosis (ALS) is the most common adult-onset paralytic disorder. It is characterized by progressive degeneration of the motor neurons controlling voluntary movement. The underlying mechanisms remain elusive, a fact that has precluded development of effective treatments. ALS presents as a sporadic condition 90-95% of the time, i.e., without familial history or obvious genetic mutation. This suggests that ALS has a strong environmental component. Organophosphates (OPs) are prime candidate neurotoxicants in the etiology of ALS, as exposure to OPs was linked to higher ALS incidence among farmers, soccer players, and Gulf War veterans...
January 9, 2017: Archives of Toxicology
https://www.readbyqxmd.com/read/28064239/recurrent-somatic-mutations-affecting-b-cell-receptor-signaling-pathway-genes-in-follicular-lymphoma
#4
Kilannin Krysiak, Felicia Gomez, Brian S White, Matthew Matlock, Christopher A Miller, Lee Trani, Catrina C Fronick, Robert S Fulton, Friederike Kreisel, Amanda F Cashen, Kenneth R Carson, Melissa M Berrien-Elliott, Nancy L Bartlett, Malachi Griffith, Obi L Griffith, Todd A Fehniger
Follicular lymphoma (FL) is the most common form of indolent non-Hodgkin lymphoma, yet it remains only partially characterized at the genomic level. In order to improve our understanding of the genetic underpinnings of this incurable and clinically heterogeneous disease, whole exome sequencing was performed on tumor/normal pairs from a discovery cohort of 24 patients with FL. Using these data, and mutations identified in other B-cell malignancies, 1716 genes were sequenced in 113 FL tumor samples, from 105 primarily treatment-naïve individuals...
November 14, 2016: Blood
https://www.readbyqxmd.com/read/28064159/prognostic-significance-of-pre-end-stage-renal-disease-serum-alkaline-phosphatase-for-post-end-stage-renal-disease-mortality-in-late-stage-chronic-kidney-disease-patients-transitioning-to-dialysis
#5
Keiichi Sumida, Miklos Z Molnar, Praveen K Potukuchi, Fridtjof Thomas, Jun Ling Lu, Yoshitsugu Obi, Connie M Rhee, Elani Streja, Kunihiro Yamagata, Kamyar Kalantar-Zadeh, Csaba P Kovesdy
BACKGROUND: Higher serum alkaline phosphatase (ALP) levels have been associated with excess mortality in patients with non-dialysis-dependent chronic kidney disease (NDD-CKD) and end-stage renal disease (ESRD). However, little is known about the impact of late-stage NDD-CKD ALP levels on outcomes after dialysis initiation. METHODS: Among 17 732 US veterans who transitioned to dialysis between October 2007 and September 2011, we examined the association of serum ALP levels averaged over the last 6 months of the pre-ESRD transition period ('prelude period') with all-cause, cardiovascular and infection-related mortality following dialysis initiation, using Cox (for all-cause mortality) and competing risk (for cause-specific mortality) regressions adjusted for demographics, comorbidities, medications, estimated glomerular filtration rate and serum albumin levels over the 6-month prelude period, and vascular access type at dialysis initiation...
January 7, 2017: Nephrology, Dialysis, Transplantation
https://www.readbyqxmd.com/read/28064158/serum-uric-acid-protein-intake-and-mortality-in-hemodialysis-patients
#6
Christina Park, Yoshitsugu Obi, Elani Streja, Connie M Rhee, Christina J Catabay, Nosratola D Vaziri, Csaba P Kovesdy, Kamyar Kalantar-Zadeh
BACKGROUND: The association between serum uric acid (SUA) and mortality has been conflicting among studies using hemodialysis (HD) patients. Given the close link between purine and protein in foods, we hypothesized that normalized protein catabolic rate (nPCR), a dietary protein intake surrogate, modifies the SUA-mortality association in the HD population. METHODS: We identified 4298 patients who initiated HD and had one or more SUA measurement in a contemporary cohort of HD patients over 5 years (1 January 2007-31 December 2011), and examined survival probability according to the first uric acid measurement, adjusting for dialysis vintage, case-mix and malnutrition-inflammation complex-related variables...
January 7, 2017: Nephrology, Dialysis, Transplantation
https://www.readbyqxmd.com/read/28050990/swinging-replantation-a-possible-protocol-for-the-management-of-inverted-impacted-upper-central-incisor-tooth
#7
Seidu A Bello, Deborah J Enebong, Emeka V Obi
Inverted tooth impaction is a rare occurrence. Third molar impaction is the most extensively studied, and only eight cases of inverted third molars have been reported in a literature search of 40 years from 1973 to 2013. In a study, 43.4% of the premaxillary supernumeraries were inverted and 21.1% were transversely oriented, while occasional inverted central incisors have been mentioned in the literature. Severe dilaceration makes the management of this case a big challenge. The case of an 8-year-old boy with an inverted, rotated, and impacted upper left central incisor obstructed by an odontome is presented here...
January 1, 2017: Journal of Contemporary Dental Practice
https://www.readbyqxmd.com/read/28049518/an-ontological-analysis-of-medical-bayesian-indicators-of-performance
#8
Adrien Barton, Jean-François Ethier, Régis Duvauferrier, Anita Burgun
BACKGROUND: Biomedical ontologies aim at providing the most exhaustive and rigorous representation of reality as described by biomedical sciences. A large part of medical reasoning deals with diagnosis and is essentially probabilistic. It would be an asset for biomedical ontologies to be able to support such a probabilistic reasoning and formalize Bayesian indicators of performance: sensitivity, specificity, positive predictive value and negative predictive value. In doing so, one has to consider that not only the positive and negative predictive values, but also sensitivity and specificity depend upon the group under consideration: this is the "spectrum effect"...
January 3, 2017: Journal of Biomedical Semantics
https://www.readbyqxmd.com/read/28048931/su-f-t-638-is-there-a-need-for-immobilization-in-srs
#9
K Masterova, A Sethi, D Anderson, V Prabhu, I Rusu, S Gros, E Melian
PURPOSE: Frameless Stereotactic radiosurgery (SRS) is increasingly used in the clinic. Cone-Beam CT (CBCT) to simulation-CT match has replaced the 3-dimensional coordinate based set up using a stereotactic localizing frame. The SRS frame however served as both a localizing and immobilizing device. We seek to measure the quality of frameless (mask based) and frame based immobilization and evaluate its impact on target dose. METHODS: Each SRS patient was set up by kV on-board imaging (OBI) and then fine-tuned with CBCT...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28048581/su-c-204-06-monte-carlo-dose-calculation-for-kilovoltage-x-ray-psoralen-activated-cancer-therapy-x-pact-preliminary-results
#10
S Mein, R Gunasingha, M Nolan, M Oldham, J Adamson
PURPOSE: X-PACT is an experimental cancer therapy where kV x-rays are used to photo-activate anti-cancer therapeutics through phosphor intermediaries (phosphors that absorb x-rays and re-radiate as UV light). Clinical trials in pet dogs are currently underway (NC State College of Veterinary Medicine) and an essential component is the ability to model the kV dose in these dogs. Here we report the commissioning and characterization of a Monte Carlo (MC) treatment planning simulation tool to calculate X-PACT radiation doses in canine trials...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28048270/su-g-jep3-06-lower-kv-image-dose-are-expected-from-a-limited-angle-intra-fractional-verification-live-system-for-sbrt-treatments
#11
G Ding, F Yin, L Ren
PURPOSE: In order to track the tumor movement for patient positioning verification during arc treatment delivery or in between 3D/IMRT beams for stereotactic body radiation therapy (SBRT), the limited-angle kV projections acquisition simultaneously during arc treatment delivery or in-between static treatment beams as the gantry moves to the next beam angle was proposed. The purpose of this study is to estimate additional imaging dose resulting from multiple tomosynthesis acquisitions in-between static treatment beams and to compare with that of a conventional kV-CBCT acquisition...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28048185/su-f-j-31-dual-energy-imaging-in-the-treatment-of-head-and-neck-tumors-a-phantom-study
#12
J Roeske, R Patel, M Surucu
PURPOSE: Organ motion, due to swallowing, can significantly affect the PTV margins used in head and neck patients. Evaluation of swallowing motion 2016 AAPM Annual Meeting Program Medical Physics, Vol. 43, No. 6, June 2016 3412 3412 may be performed using x-ray fluoroscopy. However, regions such as the soft palette and epiglottis may be difficult to visualize due to the presence of bone (mandible, teeth). The goal of this phantom study is to determine if dual energy (DE) subtraction would improve the visualization in these regions...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28048073/su-f-j-16-planar-kv-imaging-dose-reduction-study
#13
E Gershkevitsh, D Zolotuhhin
PURPOSE: IGRT has become an indispensable tool in modern radiotherapy with kV imaging used in many departments due to superior image quality and lower dose when compared to MV imaging. Many departments use manufacturer supplied protocols for imaging which are not always optimised between image quality and radiation dose (ALARA). METHODS: Whole body phantom PBU-50 (Kyoto Kagaku ltd., Japan) for imaging in radiology has been imaged on Varian iX accelerator (Varian Medical Systems, USA) with OBI 1...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28047743/su-g-jep3-11-use-of-an-easily-modified-simple-phantom-to-perform-the-daily-and-monthly-localization-qa-tasks-for-a-video-based-surface-imaging-system
#14
C Kim, E Furhang, C Devick
PURPOSE: To describe a simple, easily fabricated, Styrofoam phantom used in conjunction with a commonly available OBI phantom, to QA a video-surface imaging system according to TG147, using minimal effort. METHODS: Styrofoam, a common packaging material, reflects the speckled AlignRT light very well. A Styrofoam block was used as a partial cap to attach onto a standard Varian Marker Match phantom. The cap was engraved with two sets crosshairs on each surface, one at the 'zero'(center) and the other an 'off-centered' position, 2 cm in all three orthogonal directions...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28047625/su-f-j-129-verification-of-geometric-and-dosimetric-accuracy-of-respiratory-management-systems-using-homemade-phantom
#15
E Goksel, H Kucucuk, O Senkesen, E Tezcanli
PURPOSE: Different placements of Infrared Cameras (IRC) in CT and treatment rooms can cause gating window level (GWL) variations leading to differences between GWL used for planning and treatments. Although, Varian Clinac DHX-OBI sytem and CT are equipped with the same kind of IRC, Truebeam STx (TB) has a different type of IRC known as banana type. In this study; geometric and dosimetric accuracy of respiratory management system (RPM) for different machines were investigated with a special homemade phantom...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28047555/su-g-jep4-14-assessment-of-inter-and-intra-fractional-motion-for-extremity-soft-tissue-sarcoma-patients-by-using-in-house-real-time-optical-image-based-monitoring-system
#16
H Kim, I Kim, S Ye
PURPOSE: This study aimed to assess inter- and intra-fractional motion for extremity Soft Tissue Sarcoma (STS) patients, by using in-house real-time optical image-based monitoring system (ROIMS) with infra-red (IR) external markers. METHODS: Inter- and intra-fractional motions for five extremity (1 upper, 4 lower) STS patients received postoperative 3D conformal radiotherapy (3D-CRT) were measured by registering the image acquired by ROIMS with the planning CT image (REG_ROIMS)...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28047547/su-f-t-647-linac-based-stereotactic-radiosurgery-srs-in-the-treatment-of-trigeminal-neuralgia-detailed-description-of-srs-procedural-technique-and-reported-clinical-outcomes
#17
D Pokhrel, S Sood, R Badkul, H Jiang, T Stepp, P Camarata, F Wang
PURPOSE: SRS is an effective non-invasive alternative treatment modality with minimal-toxicity used to treat patients with medically/surgically refractory trigeminal neuralgia root(TNR) or those who may not tolerate surgical intervention. We present our linac-based SRS procedure for TNR treatment and simultaneously report our clinical outcomes. METHODS: Twenty-eight TNR-patients treated with frame-based SRS at our institution (2009-2015) with a single-fraction point-dose of 60-80Gy to TNR were included in this IRB-approved study...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28047277/tu-fg-201-01-18-month-clinical-experience-of-a-linac-daily-quality-assurance-qa-solution-using-only-epid-and-obi
#18
B Cai, B Sun, S Yaddanapudi, S Goddu, H Li, D Caruthers, J Kavanaugh, S Mutic
PURPOSE: To describe the clinical use of a Linear Accelerator (Linac) DailyQA system with only EPID and OBI. To assess the reliability over an 18-month period and improve the robustness of this system based on QA failure analysis. METHODS: A DailyQA solution utilizing an in-house designed phantom, combined EPID and OBI image acquisitions, and a web-based data analysis and reporting system was commissioned and used in our clinic to measure geometric, dosimetry and imaging components of a Varian Truebeam Linac...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28046750/su-f-j-18-feasibility-of-open-mask-immobilization-with-optical-imaging-guidance-oig-for-h-n-radiotherapy
#19
B Zhao, G Maquilan, M Anders, S Jiang, D Schwartz
PURPOSE: Full face and neck thermoplastic masks provide standard-of-care immobilization for patients receiving H&N IMRT. However, these masks are uncomfortable and increase skin dose. The purpose of this pilot study was to investigate the feasibility and setup accuracy of open face and neck mask immobilization with OIG. METHODS: Ten patients were consented and enrolled to this IRB-approved protocol. Patients were immobilized with open masks securing only forehead and chin...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28046680/su-f-j-14-kilovoltage-cone-beam-ct-dose-estimation-of-varian-on-board-imager-using-gmctdospp-monte-carlo-framework
#20
S Kim, D Rangaraj
PURPOSE: Although cone-beam CT (CBCT) imaging became popular in radiation oncology, its imaging dose estimation is still challenging. The goal of this study is to assess the kilovoltage CBCT doses using GMctdospp - an EGSnrc based Monte Carlo (MC) framework. METHODS: Two Varian OBI x-ray tube models were implemented in the GMctpdospp framework of EGSnrc MC System. The x-ray spectrum of 125 kVp CBCT beam was acquired from an EGSnrc/BEAMnrc simulation and validated with IPEM report 78...
June 2016: Medical Physics
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