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https://www.readbyqxmd.com/read/29344018/three-year-experience-in-nat-screening-of-blood-donors-for-transfusion-transmitted-viruses-in-croatia
#1
Hana Safic Stanic, Ivana Babic, Margareta Maslovic, Vesna Dogic, Jasna Bingulac-Popovic, Manuela Miletic, Nina Jurakovic-Loncar, Tomislav Vuk, Maja Strauss-Patko, Irena Jukic
Background: Croatia implemented individual donation (ID)-NAT testing of blood donors in 2013 for three viruses HBV, HCV, and HIV-1 as a mandatory test for all blood donors. This study assessed the impact of NAT screening 3 years after its implementation. Methods: A total of 545,463 donations were collected and screened for HBV, HCV, and HIV-1 using the Procleix Ultrio Plus Assay. All initially reactive (IR) NAT samples were retested in triplicate and, if repeatedly reactive (RR), NAT discriminatory assay (dNAT) was performed...
November 2017: Transfusion Medicine and Hemotherapy
https://www.readbyqxmd.com/read/29342320/association-of-pre-esrd-serum-calcium-with-post-esrd-mortality-among-incident-esrd-patients-a-cohort-study
#2
Yoshitsugu Obi, Christina Park, Melissa Soohoo, Keiichi Sumida, Takayuki Hamano, Connie M Rhee, Csaba P Kovesdy, Kamyar Kalantar-Zadeh, Elani Streja
Albumin-corrected serum calcium (cSCa) decline at late stages of chronic kidney disease and rise after dialysis initiation. While hypercalcemia is associated with higher mortality in end-stage renal disease (ESRD), there are scarce data on the impact of pre-ESRD cSCa on post-ESRD mortality. Therefore, we used a large national cohort of 21,826 US veterans with incident ESRD who transitioned to dialysis in all US Department of Veterans Affairs healthcare facilities over 2009-2014 to examine the associations with all-cause and cause-specific post-ESRD mortality of (1) cSCa concentrations averaged over the last six months and (2) its rate of decline during the last 12 months before dialysis initiation...
January 17, 2018: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/29326804/occult-hepatitis-b-virus-infection-and-associated-genotypes-among-hbsag-negative-subjects-in-burkina-faso
#3
Birama Diarra, Albert Théophane Yonli, Pegdwendé Abel Sorgho, Tegwindé Rebeca Compaore, Abdoul Karim Ouattara, Wendpagnangdé Arsène Zongo, Issoufou Tao, Lassina Traore, Serge Théophile Soubeiga, Florencia Wendkuuni Djigma, Dorcas Obiri-Yeboah, Bolni-Marius Nagalo, Virginio Pietra, Rokia Sanogo, Jacques Simpore
Background: The presence of HBV DNA in the liver (with detectable or undetectable HBV DNA in the serum) of individuals tested HBsAg negative by currently available assays is defined occult B Infection (OBI). It remains a potential transmission threat and risk to HBV chronic infection. The purpose of this study was to determine the OBI prevalence among HBsAg negative subjects and to characterize associated genotypes. Methods: Blood samples of 219 HBsAg-negative subjects tested by ELISA were collected...
2018: Mediterranean Journal of Hematology and Infectious Diseases
https://www.readbyqxmd.com/read/29326306/weekly-standard-kt-vurea-and-clinical-outcomes-in-home-and-in-center-hemodialysis
#4
Matthew B Rivara, Vanessa Ravel, Elani Streja, Yoshitsugu Obi, Melissa Soohoo, Alfred K Cheung, Jonathan Himmelfarb, Kamyar Kalantar-Zadeh, Rajnish Mehrotra
BACKGROUND AND OBJECTIVES: Patients undergoing hemodialysis with a frequency other than thrice weekly are not included in current clinical performance metrics for dialysis adequacy. The weekly standard Kt/Vurea incorporates treatment frequency, but there are limited data on its association with clinical outcomes. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: We used multivariable regression to examine the association of dialysis standard Kt/Vurea with BP and metabolic control (serum potassium, calcium, bicarbonate, and phosphorus) in patients incidental to dialysis treated with home (n=2373) or in-center hemodialysis (n=109,273)...
January 11, 2018: Clinical Journal of the American Society of Nephrology: CJASN
https://www.readbyqxmd.com/read/29322916/cells-in-experimental-life-sciences-challenges-and-solution-to-the-rapid-evolution-of-knowledge
#5
EDITORIAL
Sirarat Sarntivijai, Alexander D Diehl, Yongqun He
Cell cultures used in biomedical experiments come in the form of both sample biopsy primary cells, and maintainable immortalised cell lineages. The rise of bioinformatics and high-throughput technologies has led us to the requirement of ontology representation of cell types and cell lines. The Cell Ontology (CL) and Cell Line Ontology (CLO) have long been established as reference ontologies in the OBO framework. We have compiled a series of the challenges and the proposals of solutions in this CELLS (Cells in ExperimentaL Life Sciences) thematic series that cover the grounds of standing issues and the directions, which were discussed in the First International Workshop on CELLS at the the International Conference on Biomedical Ontology (ICBO)...
December 21, 2017: BMC Bioinformatics
https://www.readbyqxmd.com/read/29320552/first-report-of-occult-hepatitis-b-infection-among-art-na%C3%A3-ve-hiv-seropositive-individuals-in-maputo-mozambique
#6
Awa Abdul Carimo, Eduardo Samo Gudo, Cremildo Maueia, Nédio Mabunda, Lúcia Chambal, Adolfo Vubil, Ana Flora, Francisco Antunes, Nilesh Bhatt
BACKGROUND: The prevalence of hepatitis B virus (HBV) infection and human immunodeficiency virus (HIV) infection in Mozambique is one of the highest in the world, though in spite of this the prevalence of occult hepatitis B infection (OBI) is unknown. OBJECTIVES: This study was conducted with the aim to investigate the prevalence of OBI and frequency of isolated hepatitis B core antibody (anti-HBc alone) among antiretroviral (ART) naïve HIV-positive patients in Mozambique...
2018: PloS One
https://www.readbyqxmd.com/read/29317951/parafunctional-behaviors-and-its-effect-on-dental-bridges
#7
REVIEW
Amal Alharby, Hanan Alzayer, Ahmed Almahlawi, Yazeed Alrashidi, Samaa Azhar, Maan Sheikho, Anas Alandijani, Amjad Aljohani, Manal Obied
Parafunctional behaviors, especially bruxism, are not uncommon among patient visiting dentists' clinics daily and they constitute a major dental issue for almost all dentists. Many researchers have focused on the definition, pathophysiology, and treatment of these behaviors. These parafunctional behaviors have a considerable negative impact on teeth and dental prothesis. In this review, we focused on the impact of parafunctional behaviors on dental bridges. We summarized the definitions, epidemiology, pathophysiology, and consequences of parafunctional behaviors...
February 2018: Journal of Clinical Medicine Research
https://www.readbyqxmd.com/read/29316067/deep-sequencing-shows-low-level-oncogenic-hepatitis-b-virus-variants-persisting-post-liver-transplant-despite-potent-anti-hbv-prophylaxis
#8
Keith Ck Lau, Carla Osiowy, Elizabeth Giles, Beth Lusina, Guido van Marle, Kelly W Burak, Carla S Coffin
Recent studies suggest that withdrawal of hepatitis B immune globulin (HBIG) and nucleos(t)ide analogues (NA) prophylaxis may be considered in HBV surface antigen (HBsAg) negative liver transplant (LT) recipients with a low risk of disease recurrence. However, the frequency of occult HBV infection (OBI) and HBV variants after LT in the current era of potent NA therapy is unknown. 12 LT recipients on prophylaxis were tested in matched plasma and peripheral blood mononuclear cells (PBMC) for HBV quasispecies by in-house nested PCR and next generation sequencing of amplicons...
January 6, 2018: Journal of Viral Hepatitis
https://www.readbyqxmd.com/read/29315352/hepatitis-b-infection-among-hiv-infected-individuals-in-gabon-occult-hepatitis-b-enhances-hbv-dna-prevalence
#9
Berthold Bivigou-Mboumba, Marie Amougou-Atsama, Samira Zoa-Assoumou, Hervé M'boyis Kamdem, Guy Francis Nzengui-Nzengui, Angélique Ndojyi-Mbiguino, Richard Njouom, Sandrine François-Souquière
In Gabon, a central African country, human immunodeficiency virus (HIV) and hepatitis B virus (HBV) are endemic. In a recent study, conducted in a semi-urban area (Franceville, Gabon), HBV infection was found to be more prevalent among HIV infected individuals. This study aims to investigate the prevalence and genetic diversity of hepatitis B virus infection among HIV infected individuals, predominantly under antiretroviral therapy, living in fully urbanized area: Libreville, capital of Gabon. Serological and molecular tests were performed to detect HBV infection among patients living with HIV/AIDS (PLHA)...
2018: PloS One
https://www.readbyqxmd.com/read/29290910/occult-hepatitis-b-virus-infection-and-surgical-outcomes-in-non-b-non-c-patients-with-curative-resection-for-hepatocellular-carcinoma
#10
Hiroki Koga, Keita Kai, Shinichi Aishima, Atsushi Kawaguchi, Koutaro Yamaji, Takao Ide, Junji Ueda, Hirokazu Noshiro
AIM: To investigate the prevalence, clinicopathological characteristics and surgical outcomes of occult hepatitis B virus (HBV) infection (OBI) in patients with non-B, non-C (NBNC) hepatocellular carcinoma (HCC). METHODS: This study retrospectively examined the cases of 78 NBNC patients with curative resection for HCC for whom DNA could be extracted from formalin-fixed paraffin-embedded tissue. OBI was determined by the HBV-DNA amplification of at least two different sets of primers by TaqMan real-time polymerase chain reaction...
December 18, 2017: World Journal of Hepatology
https://www.readbyqxmd.com/read/29276109/determining-patient-risk-factors-associated-with-accelerated-growth-of-popliteal-artery-aneurysms
#11
Ryan S Cousins, David J Dexter, Sadaf S Ahanchi, Brandon C Cain, Obie M Powell, Sarah B Ongstad, Niraj M Parikh, Jean M Panneton
OBJECTIVE: The objective of this study was to determine the natural progression of popliteal artery aneurysms (PAAs) and clinical variables associated with their accelerated growth. METHODS: Retrospective chart review of 224 patients with encounters between January 2008 and May 2016 and with at least one PAA was conducted. From this group, 65 asymptomatic patients had either unilateral (n = 43) or bilateral (n = 22) PAAs that were observed for at least 1 year of medical management before intervention...
December 22, 2017: Journal of Vascular Surgery
https://www.readbyqxmd.com/read/29248876/associations-between-adjuvant-radiotherapy-and-different-causes-of-death-in-a-german-breast-cancer-cohort
#12
Nadia Obi, Christine Eulenburg, Petra Seibold, Ursula Eilber, Kathrin Thöne, Sabine Behrens, Jenny Chang-Claude, Dieter Flesch-Janys
BACKGROUND: Studies of cohorts of breast cancer (BC) patients diagnosed before 1990 showed radiotherapy (RT) to be associated with increased cardiovascular (CVD) and lung cancer mortality many years after diagnosis. In the late 1990s, improvements in RT planning techniques reduced radiation doses to normal tissues. Recent studies did not consistently report higher RT-related mortality for CVD and second cancers. Aim of the study was to analyze specific causes of death after 3D-conformal RT in a recent BC cohort...
December 14, 2017: Breast: Official Journal of the European Society of Mastology
https://www.readbyqxmd.com/read/29223620/impact-of-obesity-on-modality-longevity-residual-kidney-function-peritonitis-and-survival-among-incident-peritoneal-dialysis-patients
#13
Yoshitsugu Obi, Elani Streja, Rajnish Mehrotra, Matthew B Rivara, Connie M Rhee, Melissa Soohoo, Daniel L Gillen, Wei-Ling Lau, Csaba P Kovesdy, Kamyar Kalantar-Zadeh
BACKGROUND: The prevalence of severe obesity, often considered a contraindication to peritoneal dialysis (PD), has increased over time. However, mortality has decreased more rapidly in the PD population than the hemodialysis (HD) population in the United States. The association between obesity and clinical outcomes among patients with end-stage kidney disease remains unclear in the current era. STUDY DESIGN: Historical cohort study. SETTING & PARTICIPANTS: 15,573 incident PD patients from a large US dialysis organization (2007-2011)...
December 6, 2017: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
https://www.readbyqxmd.com/read/29218886/clingen-cancer-somatic-working-group-standardizing-and-democratizing-access-to-cancer-molecular-diagnostic-data-to-drive-translational-research
#14
Subha Madhavan, Deborah Ritter, Christine Micheel, Shruti Rao, Angshumoy Roy, Dmitriy Sonkin, Matthew Mccoy, Malachi Griffith, Obi L Griffith, Peter Mcgarvey, Shashikant Kulkarni
A growing number of academic and community clinics are conducting genomic testing to inform treatment decisions for cancer patients (1). In the last 3-5 years, there has been a rapid increase in clinical use of next generation sequencing (NGS) based cancer molecular diagnostic (MolDx) testing (2). The increasing availability and decreasing cost of tumor genomic profiling means that physicians can now make treatment decisions armed with patient-specific genetic information. Accumulating research in the cancer biology field indicates that there is significant potential to improve cancer patient outcomes by effectively leveraging this rich source of genomic data in treatment planning (3)...
2018: Pacific Symposium on Biocomputing
https://www.readbyqxmd.com/read/29211108/detection-of-occult-hepatitis-b-in-serum-and-oral-fluid-samples
#15
Moyra Machado Portilho, Leticia Cancella Nabuco, Cristiane Alves Villela-Nogueira, Carlos Eduardo Brandão-Mello, José Henrique Pilotto, Geane Lopes Flores, Lia Laura Lewis-Ximenez, Elisabeth Lampe, Livia Melo Villar
In occult hepatitis B infection (OBI), hepatitis B virus DNA (HBV DNA) can be detected in serum samples; however, oral fluid collection for detection of HBV DNA has not yet been explored, despite the availability of collection devices. Serum and oral fluid samples from 45 hepatitis B core antibody (anti-HBc)-positive patients were collected for the amplification of the HBV polymerase gene. HBV DNA was detected in five serum and four oral fluid samples (the detection limit for oral fluid was 1.656 log IU/mL in paired serum)...
January 2018: Memórias do Instituto Oswaldo Cruz
https://www.readbyqxmd.com/read/29192631/intermittent-testicular-torsion
#16
A O Obi
OBJECTIVE: The aim of this study is to highlight the clinical characteristics of patients with intermittent testicular torsion and draw attention to this underreported condition. METHODS: Clinical and demographic data of all patients treated for intermittent testicular torsion from January 2007 to June 2015 were prospectively collected in a pro forma and analyzed. A diagnosis of intermittent torsion was made on the basis of recurrent scrotal pain, presence of abnormal testicular lie in otherwise normal testes, absence of urinary symptoms, and negative urine cultures...
October 2017: Nigerian Journal of Clinical Practice
https://www.readbyqxmd.com/read/29180531/anion-gap-as-a-determinant-of-ionized-fraction-of-divalent-cations-in-hemodialysis-patients
#17
Yusuke Sakaguchi, Takayuki Hamano, Keiichi Kubota, Tatsufumi Oka, Satoshi Yamaguchi, Ayumi Matsumoto, Nobuhiro Hashimoto, Daisuke Mori, Yasue Obi, Isao Matsui, Yoshitaka Isaka
BACKGROUND AND OBJECTIVES: Circulating levels of anions that bind to magnesium and calcium are often altered in patients with CKD. However, it is unknown how these alterations affect the ionized fraction of magnesium and calcium. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: This cross-sectional study involved patients on maintenance hemodialysis and patients not on dialysis who visited the outpatient department of nephrology. We collected whole-blood samples to measure ionized magnesium and calcium concentrations...
November 27, 2017: Clinical Journal of the American Society of Nephrology: CJASN
https://www.readbyqxmd.com/read/29156001/dgidb-3-0-a-redesign-and-expansion-of-the-drug-gene-interaction-database
#18
Kelsy C Cotto, Alex H Wagner, Yang-Yang Feng, Susanna Kiwala, Adam C Coffman, Gregory Spies, Alex Wollam, Nicholas C Spies, Obi L Griffith, Malachi Griffith
The drug-gene interaction database (DGIdb, www.dgidb.org) consolidates, organizes and presents drug-gene interactions and gene druggability information from papers, databases and web resources. DGIdb normalizes content from 30 disparate sources and allows for user-friendly advanced browsing, searching and filtering for ease of access through an intuitive web user interface, application programming interface (API) and public cloud-based server image. DGIdb v3.0 represents a major update of the database. Nine of the previously included 24 sources were updated...
November 16, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/29154259/evaluation-of-coefficients-to-derive-organ-and-effective-doses-from-cone-beam-ct-cbct-scans-a-monte-carlo-study
#19
Abdullah Abuhaimed, Colin J Martin
Regular imaging is used throughout image guided radiation therapy (IGRT) to improve treatment delivery. In order for treatment procedures to be optimized, the doses delivered by imaging exposures should be taken into account. CT dosimetry methods based on the CT dose index (CTDI), measured with a 100 mm long pencil ionization chamber (CTDI<sub>100</sub>) in standard phantoms, are not designed for the cone beam CT (CBCT) imaging systems used in radiotherapy, therefore a modified version has been proposed for CBCT by the International Electrotechnical Commission (CTDI<sub>IEC</sub>)...
November 20, 2017: Journal of Radiological Protection: Official Journal of the Society for Radiological Protection
https://www.readbyqxmd.com/read/29144889/effect-of-dietary-fermented-mushroom-bed-on-egg-production-in-laying-hens
#20
Shu Yoshida, Hiroaki Mitani, Masato Kamata, Akira Ohtsuka, Konosuke Otomaru, Takeshi Obi, Hiroaki Kanouchi
Egg productivity is declined by stress. It has been reported that some food supplements can improve the egg productivity due to a reduction of environmental stress. We evaluated the effect of fermented waste mushroom bed (FWMB) as a dietary additive on egg productivity. Hens were fed control food (control group, n = 100) or 3% FWMB-added food (FWMB group, n = 100) for 16 months. The number of eggs, soft-shelled eggs, and broken eggs were recorded for 15 months. We also evaluated stress-related markers (ovotransferrin, lipid peroxide, and the heterophil-to-lymphocyte ratio)...
November 2017: Bioscience, Biotechnology, and Biochemistry
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