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JOURNAL ARTICLE
Dan Liang, Chang Liu, Yan Wang
BACKGROUND: The association between the triglyceride-glucose (TyG) index and the likelihood of developing cardiovascular disease (CVD) in the general elderly population in the United States aged 60 and above is not well understood. The objective of our study was to examine the relationship between the TyG index and CVD likelihood in the general elderly population over 60 years of age in the United States. METHODS: Data for this cross-sectional study were sourced from the 2003-2018 National Health and Nutrition Examination Survey...
May 3, 2024: Cardiovascular Diabetology
#2
JOURNAL ARTICLE
Chunqi Zhou, Senlin Wang, Lingling Ju, Ruimin Zhang, Yunning Yang, Yanjun Liu
PURPOSE: The exposure of Ethylene oxide (EO) is linked to systemic inflammatory response and various cardiovascular risk factors. Hemoglobin's binding to ethylene oxide (HbEO) was used to measure serum EO level. This research aims to explore the association between metabolic syndrome (MetS) and HbEO, and between HbEO and components of metabolic syndrome. METHOD: This research included 1842 participants from 2013 to 2020 in National Health and Nutrition Examination Survey (NHANES) database...
2024: Frontiers in Endocrinology
#3
JOURNAL ARTICLE
Aleksandra Zdrojowy-Wełna, Elena Valassi
Management of Cushing's syndrome (CS) can be particularly challenging in older patients, due to the lack of several clinical features associated with cortisol excess along with a greater burden of comorbidities in them, as compared with the younger. Moreover, interpretation of diagnostic tests could be influenced by age-related physiological changes of cortisol secretion. While mortality is higher and quality of life is more impaired in the elderly with CS as compared with the younger, there is currently no agreement on the most effective therapeutic options in aged individuals, and safety data concerning medical treatment are scanty...
May 2, 2024: Experimental and Clinical Endocrinology & Diabetes
#4
JOURNAL ARTICLE
Chi-Sheng Wang, Yen-Wei Pai, Ching-Heng Lin, I-Te Lee, Hsiao-Hui Chen, Ming-Hong Chang
BACKGROUND: We explore the effect of suboptimal glycemic control on the incidence of diabetic peripheral neuropathy (DPN) in both non-elderly and elderly patients with type 2 diabetes mellitus (T2DM). METHODS: A 6-year follow-up study (2013-2019) enrolled T2DM patients aged >20 without DPN. Participants were classified into two groups: those below 65 years (non-elderly) and those 65 years or older (elderly). Biochemical measurements, including glycated hemoglobin (HbA1C), were recorded regularly...
2024: Frontiers in Endocrinology
#5
John Allonce, Mohammed Ahsan, Angelina Browne, Rebecca Witherell, Mark Rasnake
Haemophilus influenzae ( H. influenzae ) has evolved as a prominent pathogen, with nontypeable strains (NTHi) emerging as a leading cause of invasive disease, particularly among the elderly. Since the introduction of Haemophilus influenzae B (Hib) vaccine, invasive infection has shifted from children with Hib to the elderly with NTHi. NTHi affects those primarily with predisposing factors such as an immunocompromised state, CSF leakage, or ENT infections. We present two cases that emphasize the shift of invasive infection, risk factors, and elevated intracranial pressure (ICP) as a complication...
2024: Case Reports in Infectious Diseases
#6
JOURNAL ARTICLE
Roberta Scairati, Renata S Auriemma, Sara Di Meglio, Guendalina Del Vecchio, Rosa Pirchio, Chiara Graziadio, Claudia Pivonello, Rosario Pivonello, Annamaria Colao
CONTEXT: Prolactin (PRL) is a crucial mediator of gluco-insulinemic metabolism. OBJECTIVE: Dissecting glucose metabolism during and after pregnancy in patients with prolactinomas. METHODS: 52 patients treated with cabergoline (CAB) were evaluated before conception, during pregnancy and up to 10 years after delivery. During pregnancy, CAB was discontinued, while it was restarted in 57.7 % of patients after delivery, due to recurrent hyperprolactinemia (RH)...
May 2, 2024: Journal of Clinical Endocrinology and Metabolism
#7
Karla Prebil, Anja Kokalj Palandacic, Polona Rus Prelog
Ranolazine is a piperazine derivative and is indicated for the symptomatic treatment of patients with stable angina pectoris who are inadequately controlled or intolerant to first-line antianginal therapies. Visual hallucinations together with neurological symptoms have been described with ranolazine treatment. In this case report, we describe a case of an elderly diabetic patient with chronic angina pectoris who developed visual hallucinations during an acute worsening of kidney function after tolerating ranolazine well for six years...
April 29, 2024: Canadian Journal of Cardiology
#8
JOURNAL ARTICLE
Elham Nejadsadeghi, Elham Eshaghi Gorji, Ahmad Vakili-Basir, Samaneh Norouzi, Seyedeh Leila Dehghani, Shahab Papi
INTRODUCTION: Urinary tract infection (UTI) is a prevalent infection among the elderly population, often culminating in more severe and life-threatening complications. The prevalence of diabetes among elderly individuals is markedly on the rise, with UTI emerging as the most prevalent infectious ailment in this diabetic cohort. This study aims to ascertain the influence of theory-based education on promoting UTI prevention behaviours among elderly diabetic women. MATERIAL AND METHODS: In this experimental study, 100 elderly women with diabetes who sought care at comprehensive health service centres in Miandoab City between January and May 2022 were assessed...
March 2024: Menopause Review
#9
Miao Sun, Min Liu, Faqiang Zhang, Lijuan Sang, Yuxiang Song, Peng Li, Siyuan Liu, Huikai Yang, Libin Ma, Jiangbei Cao, Weidong Mi, Yulong Ma
No abstract text is available yet for this article.
April 30, 2024: Lipids in Health and Disease
#10
JOURNAL ARTICLE
Chenchen Yang, Hengfa Ge, Aifeng Gong
OBJECTIVE: Given the high incidence of pulmonary complications and poor prognosis in patients with multiple rib fractures, we have developed a risk prediction model for pulmonary complications in patients with MRF. In order to identify the high-risk groups prone to pulmonary complications as early as possible, we will intervene in advance and provide targeted interventions to improve patients' quality of life and disease prognosis. METHODS: The prospective cohort study design scheme was used to collect data information based on the hospital's electronic medical record system...
April 26, 2024: Alternative Therapies in Health and Medicine
#11
JOURNAL ARTICLE
Rebeca Eriksen, Margaret C White, Adem Y Dawed, Isabel Garcia Perez, Joram M Posma, Mark Haid, Sapna Sharma, Cornelia Prehn, Louise E Thomas, Robert W Koivula, Roberto Bizzotto, Andrea Mari, Giuseppe N Giordano, Imre Pavo, Jochen M Schwenk, Federico De Masi, Konstantinos D Tsirigos, Søren Brunak, Ana Viñuela, Anubha Mahajan, Timothy J McDonald, Tarja Kokkola, Femke Rutters, Joline Beulens, Mirthe Muilwijk, Marieke Blom, Petra Elders, Tue H Hansen, Juan Fernandez-Tajes, Angus Jones, Chris Jennison, Mark Walker, Mark I McCarthy, Oluf Pedersen, Hartmut Ruetten, Ian Forgie, Jens J Holst, Henrik S Thomsen, Martin Ridderstråle, Jimmy D Bell, Jerzy Adamski, Paul W Franks, Torben Hansen, Elaine Holmes, Gary Frost, Ewan R Pearson
CONTEXT: The role of glucagon-like peptide-1(GLP-1) in Type 2 diabetes (T2D) and obesity is not fully understood. OBJECTIVE: We investigate the association of cardiometabolic, diet and lifestyle parameters on fasting and postprandial GLP-1 in people at risk of, or living with, T2D. METHOD: We analysed cross-sectional data from the two Innovative Medicines Initiative (IMI) Diabetes Research on Patient Stratification (DIRECT) cohorts, cohort 1(n=2127) individuals at risk of diabetes; cohort 2 (n=789) individuals with new-onset of T2D...
April 30, 2024: Journal of Clinical Endocrinology and Metabolism
#12
MULTICENTER STUDY
Min Young Kwak, Ho Yun Lee, Se A Lee, Junhui Jeong, Jae Ho Chung, Jin Kim, Beom Cho Jun, Seung-Geun Yeo, Sang Hoon Kim, Jong Dae Lee
BACKGROUND: This article presents a comprehensive review of data on the impact of facial palsy during the coronavirus disease 2019 (COVID-19) pandemic. The possible causes and pathophysiological mechanisms of changes in the epidemiology of facial palsy during the COVID-19 pandemic are also discussed. METHODS: This multicenter retrospective cohort study included 943 patients diagnosed with Bell's palsy or Ramsay Hunt syndrome. This study compared patient demographics, comorbidities, symptoms, and treatments before the COVID-19 pandemic (from 2017 to 2019) and during the COVID-19 pandemic, from 2020 to 2022)...
April 29, 2024: Journal of Korean Medical Science
#13
JOURNAL ARTICLE
Iliana C Lega, Wade Thompson, Lisa M McCarthy
No abstract text is available yet for this article.
April 28, 2024: Canadian Medical Association Journal: CMAJ
#14
REVIEW
Klara Gadó, Gy Ádám Tabák, István Vingender, Gyula Domján, Gabriella Dörnyei
Type 2 diabetes is a frequent chronic disease. Given its strong positive association with older age, it is a significant public health issue in elderly populations. Furthermore, the aging of the population, driven by increasing life expectancy in high and middle-income countries leads to an increasing prevalence of diabetes.Although the same diagnostic criteria apply to the elderly and to younger people, there are unique aspects to the care for elderly type 2 diabetes patients. Both treatment goals and preferred medications, as well as non-pharmacological approaches should be adjusted in the elderly...
April 29, 2024: Physiology International
#15
JOURNAL ARTICLE
Zhi-Hui Song, Qiao-Ming Huang, Shan-Shan Xu, Jian-Bo Zhou, Chao Zhang
BACKGROUND: Diabetes, a chronic disease worldwide, may be associated with a poorer prognosis in patients with coronavirus disease 2019 (COVID-19). While some antihyperglycemic medications may be beneficial, others may increase the risk of adverse clinical outcomes of COVID-19. We aimed to analyze the effect of antihyperglycemic medications on COVID-19. METHODS: We searched the Web of Science, Cochrane Library, EMBASE, PubMed, and Scopus databases from December 2019 to June 2022 to identify literature related to patients with COVID-19 and type 2 diabetes mellitus (T2DM) treated with antihyperglycemic medications...
April 29, 2024: Therapeutic Innovation & Regulatory Science
#16
REVIEW
Seyed Mohammad Hosein Hosseini Adarmanabadi, Orod Jalali Khalil Abadi, Amirhossein Amiri, Rozhina Tamannaeifar, Sahar Balanian, Mehdi Rasekhjam, Mohammad Sadra Samiazar, Sara Hasanpour, Samira Peiravi, Dorsa Alijanzadeh, Mohadeseh Poudineh, Hamidreza Amiri, Seyed Amirhossein Mazhari, Reza Khademi, Niloofar Deravi, Mobina Fathi
Due to the growth of the elderly population, age-related neurological disorders are an increasing problem. Aging begins very gradually and later leads to several neurological issues such as lower neurotransmitter levels, oxidative stress, neuronal inflammation, and continual neuronal loss. These changes might contribute to brain disorders such as Alzheimer's disease (AD), dementia or mild cognitive impairment, and epilepsy and glioma, and can also aggravate these disorders if they were previously present. Momordica charantia (bitter gourd), a member of the Cucurbitaceae family, is a good source of carbohydrates, proteins, vitamins, and minerals...
April 23, 2024: Journal of Integrative Neuroscience
#17
Khushboo Bisht, Surajbala Khuraijam, Hannah Theresa Sony, Saurabh Kumbhar
Drug-induced bullous pemphigoid (DBP) may present identical to an idiopathic type of illness. Thus, DBP should be considered as a differential diagnosis when evaluating the cause of bullous pemphigoid (BP) in elderly individuals with diabetes. We present the case of a 65-year-old "young-elderly" female who developed bullous lesions after initiation of medication. This case report casts light on a commonly prescribed antidiabetic drug, a dipeptidyl peptidase-4 inhibitor, vildagliptin, and its unforeseen complication in the elderly...
March 2024: Curēus
#18
JOURNAL ARTICLE
D Cameron, A Wilson, A E Mendham, S Wingard, R Kropinyeri, T Scriven, C Kerrigan, B Spaeth, S Stranks, B Kaambwa, S Ullah, P Worley, C Ryder
OBJECTIVES: This research program involves two phases to identify enablers and barriers to diabetes care for Aboriginal people on Ngarrindjeri country; and co-design a strength-based metabolic syndrome and Type 2 Diabetes (T2D) remission program with the Ngarrindjeri community. STUDY DESIGN: A study protocol on qualitative research. METHODS: The study will recruit Aboriginal people living on Ngarrindjeri country above 18 years of age with a diagnosis of metabolic syndrome or T2D...
June 2024: Public health in practice
#19
JOURNAL ARTICLE
Li-Zhen Zhao, Wei-Min Li, Ying Ma
BACKGROUND: Age is a significant risk factor of diabetes mellitus (DM). With the develop of population aging, the incidence of DM remains increasing. Understanding the epidemiology of DM among elderly individuals in a certain area contributes to the DM interventions for the local elderly individuals with high risk of DM. AIM: To explore the prevalence of DM among elderly individuals in the Lugu community and analyze the related risk factors to provide a valid scientific basis for the health management of elderly individuals...
April 15, 2024: World Journal of Diabetes
#20
JOURNAL ARTICLE
Rami Hejase, Ahmad Mahmoud Saleh, Hassanat R Abdel-Aziz, Arule Vellaiyan, Ahmad Khaleel Al Omari, Abrar Ahmad Al Omari
OBJECTIVE: This study aimed to explore the relationship between depressive symptoms and demographic as well as health-related variables in elderly individuals diagnosed with cancer. METHODS: A cohort of 50 elderly cancer patients participated in the study. Data collection involved the completion of surveys and assessments encompassing demographic characteristics, medical profiles, levels of depression, cognitive functioning, activities of daily living, and perceived social support...
April 1, 2024: Asian Pacific Journal of Cancer Prevention: APJCP
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