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https://www.readbyqxmd.com/read/29935483/trigonelline-mitigates-lipopolysaccharide-induced-learning-and-memory-impairment-in-the-rat-due-to-its-anti-oxidative-and-anti-inflammatory-effect
#1
Mohsen Khalili, Mitra Alavi, Elham Esmaeil-Jamaat, Tourandokht Baluchnejadmojarad, Mehrdad Roghani
Brain inflammation is associated with cognitive dysfunction, especially in elderly. Trigonelline is a plant alkaloid and a major component of coffee and fenugreek with anti-diabetic, antioxidant, anti-inflammatory, and neuroprotective effects. In this study, the beneficial effect of trigonelline against lipopolysaccharide (LPS)-induced cognitive decline was assessed in the rat. LPS was injected i.p. at a dose of 500 μg/kg to induce neuroinflammation and trigonelline was administered p.o. at doses of 20, 40, or 80 mg/kg/day 1 h after LPS that continued for one week...
June 20, 2018: International Immunopharmacology
https://www.readbyqxmd.com/read/29935370/food-insecurity-weight-and-nutritional-status-among-older-adults-attending-senior-centres-in-lisbon
#2
S Ganhão-Arranhado, C Paúl, R Ramalho, P Pereira
Nutritional status is important to elders to live without disabilities. Food Insecurity (FI) is a risk factor associated with poorer nutritional status among elderly as well as a social determinant. This research aimed to identify FI prevalence and to explore the relation between FI, weight status and socio-demographic factors. METHODS: This cross-sectional study was conducted from September 2015 to February 2016 in Lisbon. Malnutrition was determined using Mini Nutritional Assessment (MNA)...
June 13, 2018: Archives of Gerontology and Geriatrics
https://www.readbyqxmd.com/read/29932564/improving-glycemic-control-in-a-geriatric-population
#3
Odette Fisher-Glover, Barbara Edlund, Emily Johnson
This quality improvement project evaluated whether offering a series of 5 structured interdisciplinary diabetic educational teaching sessions would improve glycemic control as measured by random blood sugars (RBS) in a Program of All-Inclusive Care for the Elderly (PACE). Five diabetic educational sessions were held over a 4-week period with 50 participants (N = 50). Data were analyzed and displayed using descriptive statistics and figures. Average RBS remained steady from 176.34 pre- to 175.52 post-intervention...
July 2017: Journal of National Black Nurses' Association: JNBNA
https://www.readbyqxmd.com/read/29929831/spontaneous-chronic-subdural-hematoma-in-elderly-people-arterial-hypertension-and-other-risk-factors
#4
Aleksandar Kostić, Ivo Kehayov, Nebojša Stojanović, Vesna Nikolov, Borislav Kitov, Predrag Milošević, Emina Kostić, Hristo Zhelyazkov
BACKGROUND: The risk factors implicated in the genesis of chronic subdural hematomas include old age, alcoholism, diabetes mellitus, arachnoid cysts, coagulopathy, anticoagulant (ACTh) and antiplatelet drugs. However, no study has reported an association between arterial hypertension (HTA) and chronic subdural hematomas. Therefore, the aim of this study was to investigate whether HTA is a risk factor for spontaneous chronic subdural hematomas (SCSDHs). METHODS: This multicenter study included patients aged over 60 years and was conducted from January 2009 to the end of 2015...
June 18, 2018: Journal of the Chinese Medical Association: JCMA
https://www.readbyqxmd.com/read/29927457/validated-registry-of-pre-dialysis-chronic-kidney-disease-description-of-a-large-cohort
#5
Rosalia Maria Nunes Henriques Huaira, Rogerio Baumgratz de Paula, Marcus Gomes Bastos, Fernando Antonio Basile Colugnati, Natália Maria da Silva Fernandes
INTRODUCTION: Chronic diseases account for the majority of deaths in Brazil. These include hypertension (SAH) and diabetes mellitus (DM), which are the main causes of chronic kidney disease (CKD). OBJECTIVE: This study aimed to validate the data of an electronic health record and to point out characteristics of the profile of these users in relation to clinical quality indicators for a pre-dialytic CKD. METHODS: Retrospective cohort, August/2010 to December/2014...
June 7, 2018: Jornal Brasileiro de Nefrologia: ʹorgão Oficial de Sociedades Brasileira e Latino-Americana de Nefrologia
https://www.readbyqxmd.com/read/29923535/prevalence-of-osteoarthritis-of-knee-joint-among-adult-population-in-a-rural-area-of-kanchipuram-district-tamil-nadu
#6
Jayaseelan Venkatachalam, Murugan Natesan, Muthurajesh Eswaran, Abel K Samuel Johnson, V Bharath, Zile Singh
Background: Osteoarthritis (OA) is one of the most common degenerative disorders among the elderly population; although aging is the most important cause, research has shown that it is a complex disease with many etiologies. It is not an inevitable part of aging but rather the result of a combination of factors, many of which can be modified or prevented. Objective: The objective of this study was to assess the burden and determinants of OA knee among the adult population...
April 2018: Indian Journal of Public Health
https://www.readbyqxmd.com/read/29920621/hemostasis-and-thrombosis-in-the-oldest-old
#7
Inna Tzoran, Ron Hoffman, Manuel Monreal
There is a growing proportion of the elderly population in the Western world, and these individuals require special considerations regarding a broad variety of aspects, including treatment approaches to illnesses that affect all age groups. The hemostatic system in individuals changes considerably with aging. Specifically, changes in levels of procoagulant and natural anticoagulant factors along with thrombopathy simultaneously create a hypercoagulable state and hemostatic difficulties. Underlying morbidities, such as congestive heart failure, chronic obstructive pulmonary disease, diabetes mellitus, and cancer, increase the risk for venous and arterial thrombosis...
June 19, 2018: Seminars in Thrombosis and Hemostasis
https://www.readbyqxmd.com/read/29916564/-chronicity-and-rehabilitation-in-general-medicine-and-geriatry
#8
Ciro Esposito
OBJECTIVES: The prevalence of chronic degenerative diseases such as diabetes, chronic kidney disease, obesity, cancer is increasing and comorbidity is more frequent in older age. The elderly patients with chronic degenerative diseases experience more acute complications and hospitalizations and poorer quality of life compared to elderly patients without chronic diseases. Furthermore it is widely acknowledged that an acute care model is inappropriate for patients with chronic conditions...
February 2018: Giornale Italiano di Medicina del Lavoro Ed Ergonomia
https://www.readbyqxmd.com/read/29915736/evaluation-of-treatment-satisfaction-efficacy-and-safety-of-dipeptidyl-peptidase-4-inhibitors-in-geriatric-patients-with-type-2-diabetes-mellitus-a-cross-sectionalcomparative-study
#9
Harmanjit Singh, Avinash Chakrawarti, Harjit Singh, P Guruprasad, Yogendra Kumar Gupta
Introduction: Dipeptidyl peptidase 4 (DPP4) inhibitors are attractive agents to be used in the elderly patients with Type 2 diabetes mellitus (T2DM) because of their beneficial effects. Methods: In this cross-sectional, observational study, we evaluated and compared the treatment satisfaction using Diabetes Treatment Satisfaction Questionnaire (DTSQ) in two groups (i.e., regimens containing DPP4 inhibitors vs. other regimens). Efficacy was evaluated by assessing and comparing the glycosylated hemoglobin (HbA1c) values and the percentage of patients who achieved the glycemic control (HbA1c <7%)...
January 2018: Journal of Family Medicine and Primary Care
https://www.readbyqxmd.com/read/29915618/ambulatory-blood-pressure-monitoring-antihypertensive-therapy-and-the-risk-of-fall-injuries-in-elderly-hypertensive-patients
#10
Michael Jonas, Rasisa Kazarski, Gil Chernin
Background: Fall injuries are common among the elderly. The aim of this study was to investigate whether blood-pressure patterns, as measured by 24-h ambulatory blood pressure monitoring (ABPM), or intensification of antihypertensive therapy following the 24-h ABPM, may be associated with fall injuries in hypertensive elderly patients. Methods: In a retrospective study, community-based elderly patients (age ≥ 70 years) who were referred to 24-h ABPM were evaluated for fall injuries within one-year post-ABPM...
April 2018: Journal of Geriatric Cardiology: JGC
https://www.readbyqxmd.com/read/29915435/lifestyle-intervention-using-internet-of-things-iot-for-the-elderly-a-study-protocol-for-a-randomized-control-trial-the-best-life-study
#11
Sawako Kato, Masahiko Ando, Takaaki Kondo, Yasuko Yoshida, Hiroyuki Honda, Shoichi Maruyama
Modification of lifestyle habits, including diet and physical activity, is essential for the prevention and control of type 2 diabetes mellitus (T2DM) in elderly patients. However, individualized treatment is more critical for the elderly than for general patients. This study aimed to determine lifestyle interventions that resulted in lowering hemoglobin A1c (HbA1c ) in Japanese pre- and early diabetic elderly subjects. The BEST-LIFE trial is an ongoing, open-label, 6-month, randomized (1:1) parallel group trial...
May 2018: Nagoya Journal of Medical Science
https://www.readbyqxmd.com/read/29914654/outcomes-of-appendectomy-in-elderly-veteran-patients
#12
Oswaldo Renteria, Zain Shahid, Sergio Huerta
BACKGROUND: Some studies indicate that noncomplicated acute appendicitis might be treated exclusively with antibiotics instead of an appendectomy. This study was undertaken to assess outcomes in elderly veterans and to determine if operative intervention would lead to substantial complications such that a nonoperative strategy should be investigated. METHODS: A retrospective, single-institution analysis was conducted of patients who underwent an appendectomy at the VA North Texas Health Care System over a period of 12 years (from July 2005 to June 2017)...
June 16, 2018: Surgery
https://www.readbyqxmd.com/read/29914550/ageing-with-chagas-disease-an-overview-of-an-urban-brazilian-cohort-in-rio-de-janeiro
#13
Alexandre Gomes Vizzoni, Margareth Catoia Varela, Luiz Henrique Conde Sangenis, Alejandro Marcel Hasslocher-Moreno, Pedro Emmanuel Alvarenga Americano do Brasil, Roberto Magalhães Saraiva
BACKGROUND: Chagas disease control programmes have decreased the prevalence of Chagas disease in Latin America. Together with migration to urban areas and increase in life expectancy, a new scenario for Chagas disease has emerged in Brazil with most patients currently elderly individuals living in urban areas. However, acute Chagas disease cases still occur due to vector transmission by sylvatic vectors and oral transmission by contaminated food. Therefore, we characterized the clinical and epidemiological profile of the patients followed at Evandro Chagas National Institute of Infectious Diseases in Rio de Janeiro, Brazil...
June 19, 2018: Parasites & Vectors
https://www.readbyqxmd.com/read/29914063/traditional-chinese-medical-care-and-incidence-of-stroke-in-elderly-patients-treated-with-antidiabetic-medications
#14
Yun-Wen Chiao, Yu-Jen Chen, Yu-Hsien Kuo, Chung-Yen Lu
OBJECTIVES: Experimental research has shown that herbal and traditional Chinese medicines (TCM) may serve as complements to Western medicine treatments in the control of blood glucose and cardiovascular complications, but population-based studies are limited. We investigated the association between TCM use and subsequent risk of stroke in older patients with diabetes. STUDY DESIGN: The database used in this cohort study contained longitudinal medical claims for one million subjects randomly selected among beneficiaries of a universal health care program in Taiwan...
June 15, 2018: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/29910091/meal-derived-glucagon-responses-are-related-to-lower-hepatic-phosphate-concentrations-in-obesity-and-type-2-diabetes
#15
K S Weber, K Straßburger, M Fritsch, A Bierwagen, C Koliaki, E Phielix, G Pacini, J-H Hwang, D F Markgraf, V Burkart, K Müssig, J Szendroedi, M Roden
AIM: Type 2 diabetes (T2D) alters glucagon, glucagon-like peptide (GLP)-1, glucose-dependent insulinotropic polypeptide (GIP) and hepatic energy metabolism, yet the possible relationships remain unclear. METHODS: In this observational study, lean insulin-sensitive control subjects (BMI: 23.2±1.5kg/m2 ), age-matched insulin-resistant obese subjects (BMI: 34.3±1.7kg/m2 ) and similarly obese elderly T2D patients (BMI: 32.0±2.4kg/m2 ) underwent mixed-meal tolerance tests (MMTTs), and assessment of hepatic γATP, inorganic phosphate (Pi ) and lipids using 31 P/1 H magnetic resonance spectroscopy...
June 2, 2018: Diabetes & Metabolism
https://www.readbyqxmd.com/read/29907148/a-case-of-metaplastic-atrophic-gastritis-in-immune-dysregulation-polyendocrinopathy-enteropathy-x-linked-ipex-syndrome
#16
Youyou Luo, Jie Chen, Youhong Fang, Jingan Lou, Jindan Yu
BACKGROUND: Autoimmune metaplastic atrophic gastritis is a chronic progressive inflammatory condition. The clinical spectrum includes pernicious anemia, atrophic gastritis, antibodies to parietal cell antigens and intrinsic factor, achlorhydria, hypergastrinemia and carcinoma. It is rare in paediatric cohorts. CASE PRESENTATION: We present the case of a boy with metaplastic atrophic gastritis in whom immune dysregulation, polyendocrinopathy, enteropathy, X-linked(IPEX) syndrome was confirmed by FOXP3 gene mutation...
June 15, 2018: BMC Pediatrics
https://www.readbyqxmd.com/read/29907132/association-between-multiple-comorbidities-and-self-rated-health-status-in-middle-aged-and-elderly-chinese-the-china-kadoorie-biobank-study
#17
Xingyue Song, Jing Wu, Canqing Yu, Wenhong Dong, Jun Lv, Yu Guo, Zheng Bian, Ling Yang, Yiping Chen, Zhengming Chen, An Pan, Liming Li
BACKGROUND: Understanding the correlates of self-rated health (SRH) can help public health professionals prioritize health-promotion and disease-prevention interventions. This study aimed to investigate the association between multiple comorbidities and global SRH and age-comparative SRH. METHODS: A total of 512,891 participants aged 30-79 years old were recruited into the China Kadoorie Biobank study from ten regions between 2004 and 2008. Multivariate logistic regression models were used to estimate the odds ratios (ORs) for the associations between comorbidities (including diabetes, hypertension, coronary heart disease, rheumatic heart disease, stroke, tuberculosis, emphysema/bronchitis, asthma, cirrhosis/chronic hepatitis, peptic ulcer, gallbladder disease, kidney disease, fracture, rheumatic arthritis, psychiatric disorders, depressive symptoms, neurasthenia, head injury and cancer) and SRH...
June 15, 2018: BMC Public Health
https://www.readbyqxmd.com/read/29907099/loss-of-job-related-right-to-healthcare-associated-with-employment-turnover-challenges-for-the-mexican-health-system
#18
Germán Guerra, Emilio Gutiérrez-Calderón, Nelly Salgado de Snyder, Víctor Hugo Borja-Aburto, Adolfo Martínez-Valle, Miguel Ángel González-Block
BACKGROUND: The Mexican health system segments access and right to healthcare according to worker position in the labour market. In this contribution we analyse how access and continuity of healthcare gets interrupted by employment turnover in the labour market, including its formal and informal sectors, as experienced by affiliates to the Mexican Institute of Social Security (IMSS) at national level, and of workers with type 2 diabetes (T2DM) in Mexico City. METHODS: Using data from the National Employment and Occupation Survey, 2014, and from IMSS electronic medical records for workers in Mexico City, we estimated annual employment turnover rates to measure the loss of healthcare access due to labour market dynamics...
June 15, 2018: BMC Health Services Research
https://www.readbyqxmd.com/read/29904639/effects-of-walking-on-coronary-heart-disease-in-elderly-men-with-diabetes
#19
Chieko Kimata, Bradley Willcox, Beatriz L Rodriguez
Previous studies have shown that walking is associated with increased longevity and a reduced risk of cardiovascular and age-related diseases. Whether walking benefits individuals with diabetes who are at high risk of coronary heart disease (CHD) remains to be determined. The objective of this study is to examine the association between walking and risk of CHD among elderly men with and without diabetes. Walking data was assessed in 2732 men aged 71 to 93 years participating in the Honolulu Heart Program from 1991-1993...
June 2018: Geriatrics
https://www.readbyqxmd.com/read/29904291/medical-and-psychosocial-needs-of-the-puerto-rican-people-after-hurricane-maria
#20
Lilly Ramphal
A community clinic in Puerto Rico, the Bantiox Clinic, was developed to serve the medical needs of Toa Baja and the surrounding communities after Hurricanes Irma and Maria in response to an urgent need for medical treatment of the community residents. Within 4 months, the clinic had 4941 total visits. The Toa Baja residents used the clinic more than the offsite residents. Certain offsite towns needed medical care more than others, suggesting a lack of medical access in the mountainous areas. Elderly patients with chronic diseases were served more than younger patients...
July 2018: Proceedings of the Baylor University Medical Center
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