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https://www.readbyqxmd.com/read/28210786/females-younger-patients-and-patients-with-high-bmi-have-the-highest-pre-operative-knee-awareness-measured-using-the-forgotten-joint-score
#1
Dana Li, A Troelsen, L Ingelsrud, H Husted, K Gromov
PURPOSE: The Forgotten Joint Score (FJS) is a novel measurement for patients' awareness of their knee in daily life. By identifying factors that could explain pre-operative FJS levels, the clinician could better prioritize and single out patients who would benefit most from TKA. The aim of this study was to identify possible factors that may explain the variance of pre-operative FJS levels and evaluate the relationship between pre-operative FJS and pre-operative Oxford Knee Score (OKS)...
February 16, 2017: Knee Surgery, Sports Traumatology, Arthroscopy: Official Journal of the ESSKA
https://www.readbyqxmd.com/read/28210246/prospects-of-in-vivo-incorporation-of-non-canonical-amino-acids-for-the-chemical-diversification-of-antimicrobial-peptides
#2
Tobias Baumann, Jessica H Nickling, Maike Bartholomae, Andrius Buivydas, Oscar P Kuipers, Nediljko Budisa
The incorporation of non-canonical amino acids (ncAA) is an elegant way for the chemical diversification of recombinantly produced antimicrobial peptides (AMPs). Residue- and site-specific installation methods in several bacterial production hosts hold great promise for the generation of new-to-nature AMPs, and can contribute to tackle the ongoing emergence of antibiotic resistance in pathogens. Especially from a pharmacological point of view, desirable improvements span pH and protease resistance, solubility, oral availability and circulation half-life...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28209443/continued-benefit-to-rectal-separation-for-prostate-radiation-therapy-final-results-of%C3%A2-a%C3%A2-phase-iii-trial
#3
Daniel A Hamstra, Neil Mariados, John Sylvester, Dhiren Shah, Lawrence Karsh, Richard Hudes, David Beyer, Steven Kurtzman, Jeffrey Bogart, R Alex Hsi, Michael Kos, Rodney Ellis, Mark Logsdon, Shawn Zimberg, Kevin Forsythe, Hong Zhang, Edward Soffen, Patrick Francke, Constantine Mantz, Peter Rossi, Theodore DeWeese, Stephanie Daignault-Newton, Benjamin W Fischer-Valuck, Anupama Chundury, Hiram Gay, Walter Bosch, Jeff Michalski
PURPOSE: SpaceOAR, a Food and Drug Administration-approved hydrogel intended to create a rectal-prostate space, was evaluated in a single-blind phase III trial of image guided intensity modulated radiation therapy. A total of 222 men were randomized 2:1 to the spacer or control group and received 79.2 Gy in 1.8-Gy fractions to the prostate with or without the seminal vesicles. The present study reports the final results with a median follow-up period of 3 years. METHODS AND MATERIALS: Cumulative (Common Terminology Criteria for Adverse Events, version 4...
December 23, 2016: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/28208212/the-function-of-the-ocelloid-and-piston-in-the-dinoflagellate-erythropsidinium-gymnodiniales-dinophyceae
#4
Fernando Gómez
The marine dinoflagellate Erythropsidinium possesses an ocelloid, the most elaborate photoreceptor organelle known in a unicellular organism, and a piston, a fast contractile appendage unknown in any other organism. The ocelloid is able to rotate, often before the cell swims. The ocelloid contains lenses that function to concentrate light. The flagellar propulsion is atrophied, and the piston is responsible for locomotion through successive extensions and contractions. During the 'locomotion mode', the contraction is ~4 times faster than the extension...
February 16, 2017: Journal of Phycology
https://www.readbyqxmd.com/read/28207786/hearing-flashes-and-seeing-beeps-timing-audiovisual-events
#5
Manuel Vidal
Many events from daily life are audiovisual (AV). Handclaps produce both visual and acoustic signals that are transmitted in air and processed by our sensory systems at different speeds, reaching the brain multisensory integration areas at different moments. Signals must somehow be associated in time to correctly perceive synchrony. This project aims at quantifying the mutual temporal attraction between senses and characterizing the different interaction modes depending on the offset. In every trial participants saw four beep-flash pairs regularly spaced in time, followed after a variable delay by a fifth event in the test modality (auditory or visual)...
2017: PloS One
https://www.readbyqxmd.com/read/28206823/the-effect-of-high-dose-ionizing-radiation-on-the-isolated-photobiont-of-the-astrobiological-model-lichen-circinaria-gyrosa
#6
Joachim Meeßen, Theresa Backhaus, Annette Brandt, Marina Raguse, Ute Böttger, Jean-Pierre de Vera, Rosa de la Torre
Lichen symbioses between fungi and algae represent successful life strategies to colonize the most extreme terrestrial habitats. Consequently, space exposure and simulation experiments have demonstrated lichens' high capacity for survival, and thus, they have become models in astrobiological research with which to discern the limits and limitations of terrestrial life. In a series of ground-based irradiation experiments, the STARLIFE campaign investigated the resistance of astrobiological model organisms to galactic cosmic radiation, which is one of the lethal stressors of extraterrestrial environments...
February 2017: Astrobiology
https://www.readbyqxmd.com/read/28206821/simulated-space-radiation-impact-of-four-different-types-of-high-dose-ionizing-radiation-on-the-lichen-xanthoria-elegans
#7
Annette Brandt, Joachim Meeßen, Reiner U Jänicke, Marina Raguse, Sieglinde Ott
This study addresses the viability of the lichen Xanthoria elegans after high-dose ionizing irradiation in the frame of the STARLIFE campaign. The first set of experiments was intended to resemble several types of galactic cosmic radiation (GCR) as present beyond the magnetic shield of Earth. In the second set of experiments, γ radiation up to 113 kGy was applied to test the limit of lichen resistance to ionizing radiation. Entire thalli of Xanthoria elegans were irradiated in the anhydrobiotic state. After STARLIFE 1, the metabolic activity of both symbionts was quantified by live/dead staining with confocal laser scanning microscopy...
February 2017: Astrobiology
https://www.readbyqxmd.com/read/28192262/intra-operative-ultrasonography-for-definition-of-less-invasive-surgical-technique-in-patients-with-chiari-type-i-malformation
#8
Roger Schmidt Brock, Mario Augusto Taricco, Matheus Fernandes de Oliveira, Marcelo de Lima Oliveira, Manoel Jacobsen Teixeira, Edson Bor-Seng-Shu
INTRODUCTION: Chiari malformation Type I (CM) is the main congenital malformation disease of the craniovertebral junction. The ideal surgical treatment is still controversial. Invasive procedures inside CSF space and associated with dural repair are considered the gold standard, however a less invasive surgery with isolated bone decompression without dural opening may be possible in selected patients.. Our study evaluates the efficacy of intra-operative CSF flow measurement with ultrasonography (USG) as a determining parameter in the selection of these patients...
February 9, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28190725/metapopulation-tracking-juvenile-penguins-reveals-an-ecosystem-wide-ecological-trap
#9
Richard B Sherley, Katrin Ludynia, Bruce M Dyer, Tarron Lamont, Azwianewi B Makhado, Jean-Paul Roux, Kylie L Scales, Les G Underhill, Stephen C Votier
Climate change and fisheries are transforming the oceans, but we lack a complete understanding of their ecological impact [1-3]. Environmental degradation can cause maladaptive habitat selection, inducing ecological traps with profound consequences for biodiversity [4-6]. However, whether ecological traps operate in marine systems is unclear [7]. Large marine vertebrates may be vulnerable to ecological traps [6], but their broad-scale movements and complex life histories obscure the population-level consequences of habitat selection [8, 9]...
January 30, 2017: Current Biology: CB
https://www.readbyqxmd.com/read/28188012/-end-of-life-care-difficulties-in-intensive-care-units-the-nurses-perspective
#10
Juan Francisco Velarde-García, Raquel Luengo-González, Raquel González-Hervías, Sergio González-Cervantes, Beatriz Álvarez-Embarba, Domingo Palacios-Ceña
OBJECTIVE: To describe the difficulties perceived by nursing staff in the delivery of end-of-life care to critically ill patients within intensive care units (ICU). METHOD: A descriptive phenomenological qualitative study was performed. A purposeful and snowball sampling of nursing staff with at least 1 year's previous experience working in an ICU was conducted. Twenty-two participants were enrolled. Data collection strategies included in-depth unstructured and semi-structured interviews and researcher's field notes...
February 7, 2017: Gaceta Sanitaria
https://www.readbyqxmd.com/read/28186217/time-and-space-resolved-study-of-the-methanol-to-hydrocarbons-mth-reaction-influence-of-zeolite-topology-on-axial-deactivation-patterns
#11
Daniel Rojo-Gama, Samaneh Etemadi, Eliot Kirby, Karl Petter Lillerud, Pablo Beato, Stian Svelle, Unni Olsbye
Zeolites representing seven different topologies were subjected to life-time assessment studies as methanol to hydrocarbons (MTH) catalysts at 400 °C, P(MeOH) = 13 kPa and P(tot) = 100 kPa. The following topologies were studied: ZSM-22 (TON), ZSM-23 (MTT), IM-5 (IMF), ITQ-13 (ITH), ZSM-5 (MFI), mordenite (MOR) and beta (BEA). Two experimental approaches were used. In the first approach, each catalyst was tested at three different contact times, all giving 100% initial conversion. The life-time before conversion decreased to 50% at each contact time was measured and used to calculate critical contact times (i...
February 10, 2017: Faraday Discussions
https://www.readbyqxmd.com/read/28185374/estimating-the-ability-of-plants-to-plastically-track-temperature-mediated-shifts-in-the-spring-phenological-optimum
#12
Christine J Tansey, Jarrod D Hadfield, Albert B Phillimore
One consequence of rising spring temperatures is that the optimum timing of key life-history events may advance. Where this is the case, a population's fate may depend on the degree to which it is able to track a change in the optimum timing either via plasticity or via adaptation. Estimating the effect that temperature change will have on optimum timing using standard approaches is logistically challenging, with the result that very few estimates of this important parameter exist. Here we adopt an alternative statistical method that substitutes space for time to estimate the temperature sensitivity of the optimum timing of 22 plant species based on >200 000 spatiotemporal phenological observations from across the United Kingdom...
February 10, 2017: Global Change Biology
https://www.readbyqxmd.com/read/28165409/older-people-s-experiences-of-mobility-and-mood-in-an-urban-environment-a-mixed-methods-approach-using-electroencephalography-eeg-and-interviews
#13
Sara Tilley, Chris Neale, Agnès Patuano, Steve Cinderby
There are concerns about mental wellbeing in later life in older people as the global population becomes older and more urbanised. Mobility in the built environment has a role to play in improving quality of life and wellbeing, as it facilitates independence and social interaction. Recent studies using neuroimaging methods in environmental psychology research have shown that different types of urban environments may be associated with distinctive patterns of brain activity, suggesting that we interact differently with varying environments...
February 4, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/28161416/production-of-glucosyl-glycerol-by-immobilized-sucrose-phosphorylase-options-for-enzyme-fixation-on-a-solid-support-and-application-in-microscale-flow-format
#14
Juan M Bolivar, Christiane Luley-Goedl, Ernestine Leitner, Thornthan Sawangwan, Bernd Nidetzky
2-O-(α-d-Glucopyranosyl)-sn-glycerol (αGG) is a natural osmolyte. αGG is produced industrially for application as an active cosmetic ingredient. The biocatalytic process involves a selective transglucosylation from sucrose to glycerol catalyzed by sucrose phosphorylase (SPase). Here we examined immobilization of SPase (from Leuconostoc mesenteroides) on solid support with the aim of enabling continuous production of αGG. By fusing SPase to the polycationic binding module Zbasic2 we demonstrated single-step noncovalent immobilization of the enzyme chimera to different porous supports offering an anionic surface...
February 1, 2017: Journal of Biotechnology
https://www.readbyqxmd.com/read/28157420/taking-care-bringing-life-a-post-structuralist-feminist-analysis-of-maternal-discourses-of-mothers-and-dais-in-india
#15
Vinita Agarwal
My post-structuralist feminist reading of the antenatal and birthing practices of women (N = 25) living in a basti in India makes visible how the meanings of maternal experiences constituted as our ways open discursive spaces for the mothers and dais as procreators to: challenge (i.e., question the authority of), co-opt (i.e., conditionally adopt), and judge (i.e., employ sanctioned criteria to regulate) competing knowledge production forms. In critiquing maternal knowledge as feminist discourse, the women's strategies contribute theoretically to an integrative construction of care by reclaiming displaced knowledge discourses and diversity in meaning production...
February 3, 2017: Health Communication
https://www.readbyqxmd.com/read/28157392/relay-for-life-as-a-storytelling-occasion-building-community-in-the-midst-of-suffering
#16
Melissa Rizzo Weller
In this essay, I reflect on my experiences with Relay for Life (RFL), the American Cancer Society's walking event focused on raising awareness and donations for research and patient support programs. I share stories of relationships built within this context and how those relationships are fostered by storytelling. I also draw on literature that brings to light the neoliberal effects of fundraising for health-related causes. In spite of the consumerism that is inherent in fundraising events such as RFL, those of us affected by cancer benefit from the connections created and nurtured in those spaces...
February 3, 2017: Health Communication
https://www.readbyqxmd.com/read/28156059/magnetic-nanoparticles-for-efficient-delivery-of-growth-factors-stimulation-of-peripheral-nerve-regeneration
#17
Martina Giannaccini, M Pilar Calatayud, Andrea Poggetti, Silvia Corbianco, Michela Novelli, Melania Paoli, Pietro Battistini, Maura Castagna, Luciana Dente, Paolo Parchi, Michele Lisanti, Gabriella Cavallini, Concepción Junquera, Gerardo F Goya, Vittoria Raffa
The only clinically approved alternative to autografts for treating large peripheral nerve injuries is the use of synthetic nerve guidance conduits (NGCs), which provide physical guidance to the regenerating stump and limit scar tissue infiltration at the injury site. Several lines of evidence suggest that a potential future strategy is to combine NGCs with cellular or molecular therapies to deliver growth factors that sustain the regeneration process. However, growth factors are expensive and have a very short half-life; thus, the combination approach has not been successful...
February 3, 2017: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/28152175/life-space-assessment-predicts-hospital-readmission-in-home-limited-adults
#18
Roya Fathi, Peter Bacchetti, Mary N Haan, Thomas K Houston, Kanan Patel, Christine S Ritchie
OBJECTIVES: To describe the association between restricted life-space and characteristics of community-dwelling adults hospitalized for congestive heart failure (CHF) or chronic obstructive pulmonary disease (COPD), to estimate the effect of hospitalization on postdischarge mobility, and to determine whether baseline restricted life-space predicts hospital readmission. DESIGN: Observational. SETTING: Urban academic hospital that serves as a safety net for urban and rural populations with low resources and serves central and northern Alabama...
February 2, 2017: Journal of the American Geriatrics Society
https://www.readbyqxmd.com/read/28152168/life-space-mobility-change-predicts-6-month-mortality
#19
Richard E Kennedy, Patricia Sawyer, Courtney P Williams, Alexander X Lo, Christine S Ritchie, David L Roth, Richard M Allman, Cynthia J Brown
OBJECTIVES: To examine 6-month change in life-space mobility as a predictor of subsequent 6-month mortality in community-dwelling older adults. DESIGN: Prospective cohort study. SETTING: Community-dwelling older adults from five Alabama counties in the University of Alabama at Birmingham (UAB) Study of Aging. PARTICIPANTS: A random sample of 1,000 Medicare beneficiaries, stratified according to sex, race, and rural or urban residence, recruited between November 1999 and February 2001, followed by a telephone interview every 6 months for the subsequent 8...
February 2, 2017: Journal of the American Geriatrics Society
https://www.readbyqxmd.com/read/28151789/creating-a-sacred-space-in-the-intensive-care-unit-at-the-end-of-life
#20
Ann L Fournier
Improving care at the end of life is a health priority. At least one-third of deaths in the United States occur in the hospital; nearly half of the Americans who die in the hospital will have spent time in the intensive care unit during the last 3 days of life. Critically ill patients and their families identify significant unmet spiritual, environmental, and communication needs. Although the Society of Critical Care Medicine recommends that the spiritual needs of critically ill patients be addressed by the health care team and be incorporated in patients' plans of care, spiritual concerns are infrequently addressed during goals-of-care discussions...
March 2017: Dimensions of Critical Care Nursing: DCCN
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