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https://www.readbyqxmd.com/read/29788359/sphingosine-1-phosphate-signaling-and-metabolism-gene-signature-in-pediatric-inflammatory-bowel-disease-a-matched-case-control-pilot-study
#1
Jung H Suh, Émilie Degagné, Elizabeth E Gleghorn, Mala Setty, Alexis Rodriguez, K T Park, Sofia G Verstraete, Melvin B Heyman, Ashish S Patel, Melissa Irek, Ginny L Gildengorin, Neil E Hubbard, Alexander D Borowsky, Julie D Saba
Goal: The aim of this study was to investigate gene expression levels of proteins involved in sphingosine-1-phosphate (S1P) metabolism and signaling in a pediatric inflammatory bowel disease (IBD) patient population. Background: IBD is a debilitating disease affecting 0.4% of the US population. The incidence of IBD in childhood is rising. Identifying effective targeted therapies that can be used safely in young patients and developing tools for selecting specific candidates for targeted therapies are important goals...
May 18, 2018: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/29780594/role-of-endoscopy-in-inflammatory-bowel-disease
#2
REVIEW
Shishira Bharadwaj, Neeraj Narula, Parul Tandon, Mohammad Yaghoobi
Crohn's disease (CD) and ulcerative colitis (UC) constitute the two most common phenotypes of inflammatory bowel disease (IBD). Ileocolonoscopy with biopsy has been considered the gold standard for the diagnosis of IBD. Differential diagnosis of CD and UC is important, as their medical and surgical treatment modalities and prognoses can be different. However, approximately 15% of patients with IBD are misdiagnosed as IBD unclassified due to the lack of diagnostic certainty of CD or UC. Recently, there has been increased recognition of the role of the therapeutic endoscopist in the field of IBD...
May 2018: Gastroenterology Report
https://www.readbyqxmd.com/read/29739674/diffusion-weighted-mri-in-inflammatory-bowel-disease
#3
REVIEW
Lieven Pouillon, Valérie Laurent, Marc Pouillon, Peter Bossuyt, Christiana Bonifacio, Silvio Danese, Parakkal Deepak, Edward V Loftus, David H Bruining, Laurent Peyrin-Biroulet
Cross-sectional MRI is an attractive alternative to endoscopy for the objective assessment of patients with inflammatory bowel disease (IBD). Diffusion-weighted imaging is a specialised technique that maps the diffusion of water molecules in biological tissues and can be done without intravenous gadolinium contrast injection. Diffusion-weighted imaging further expands the capability of traditional MRI sequences in IBD. However, the use of quantitative parameters, such as the apparent diffusion coefficient, is limited by low reproducibility...
June 2018: Lancet. Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/29730691/the-importance-of-intestinal-ultrasound-and-elastographic-techniques-in-inflammatory-bowel-diseases
#4
REVIEW
Andreea Marin, Laura Tribus, Carmen Fierbinteanu-Braticevici
Inflammatory bowel diseases have an important impact upon the economic and social status due to their increasing incidence and prevalence, often affecting young people. At the moment, the therapeutic goal goes beyond the improvement of symptoms and laboratory parameters, being represented by endoscopic mucosal healing, changing the disease's natural history. Even though endoscopy is the gold standard for the assessment of mucosal healing, it is an invasive maneuver and it lacks good repeatability. These patients require frequent evaluation; therefore, interest for noninvasive techniques has risen...
May 2, 2018: Medical Ultrasonography
https://www.readbyqxmd.com/read/29722891/management-of-crohn-s-disease-and-complications-in-patients-with-ostomies
#5
Xinying Wang, Bo Shen
Fecal diversion with ostomy construction can be a temporary or definitive surgical measure for the treatment of refractory inflammatory bowel disease (IBD). However, the fecal diversion surgery is associated with various stoma, peristomal complications, and recurrence or occurrence of de novo small bowel Crohn's disease (CD). Stoma complications often need enterostomal therapy or surgical revision. Peristomal cutaneous lesions, such as pyoderma gangrenosum, usually require immunomodulator or biological therapy...
May 2, 2018: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/29706011/clinical-usefulness-of-the-faecal-calprotectin-test-in-suspected-paediatric-inflammatory-bowel-disease
#6
Anthony K Akobeng
AIM: The faecal calprotectin (FC) test is increasingly being used in clinical practice to help select children with gastrointestinal symptoms who might have inflammatory bowel disease (IBD) and benefit from endoscopies. We provide an overview of the advantages and limitations of the FC test. METHODS: PubMed was searched for meta-analyses that had investigated the diagnostic accuracy of the FC test and the pooled sensitivity and specificity for distinguishing IBD from non-IBD patients were used to calculate likelihood ratios...
April 29, 2018: Acta Paediatrica
https://www.readbyqxmd.com/read/29705029/usefulness-of-contrast-enhanced-ultrasound-ceus-in-inflammatory-bowel-disease-ibd
#7
REVIEW
Silvia Pecere, Grainne Holleran, Maria Elena Ainora, Matteo Garkovic, Franco Scaldaferri, Antonio Gasbarrini, Maria Assunta Zocco
Intestinal ultrasonography has emerged as a cheap, non-invasive and readily accessible modality for the assessment of a number of gastroenterological diseases. Over the last decade, particularly due to the widespread use of biological agents in Inflammatory Bowel Disease (IBD), guidelines regarding management and follow-up advise more regular disease assessment and surveillance in order to guide treatment adjustments, and provide more personalised care. Given the young age of the majority of patients with IBD the availability of an alternative modality to harmful radiation or the risks of endoscopy for this indication offers an appealing advantage...
April 3, 2018: Digestive and Liver Disease
https://www.readbyqxmd.com/read/29700559/-primary-sclerosing-cholangitis-current-diagnostics-and-treatment
#8
REVIEW
T Liwinski, C Schramm
Primary sclerosing cholangitis (PSC) is a chronic cholestatic liver disease of unknown etiology. Characteristic features are multifocal strictures and dilatations of the bile ducts. In 60-80 % of cases the PSC is strongly associated with chronic inflammatory bowel disease, mostly in the form of pancolitis. The diagnosis is established based on detection of typical cholangiographic lesions of the bile ducts and exclusion of secondary causes of sclerosing cholangitis. There is no approved medical treatment, but in Germany ursodeoxycholic acid is frequently used...
April 26, 2018: Der Internist
https://www.readbyqxmd.com/read/29685526/paediatric-magnetic-resonance-enterography-in-inflammatory-bowel-disease
#9
Mary-Louise C Greer
Paediatric magnetic resonance enterography (MRE) has been increasingly employed in the evaluation of inflammatory bowel disease (IBD) in the past decade. This is in parallel with a global rise in paediatric-onset IBD, greater recognition of the hazards of ionizing radiation, especially in children, and improved treatment options. MRE is now the reference standard for assessing the small bowel in suspected or proven paediatric IBD, and is central to the diagnosis of Crohn's disease (CD), helping distinguish it from ulcerative colitis...
May 2018: European Journal of Radiology
https://www.readbyqxmd.com/read/29673053/vedolizumab-as-a-rescue-therapy-for-patients-with-medically-refractory-crohn-s-disease
#10
Kristen T Crowell, Andrew Tinsley, Emmanuelle D Williams, Matthew D Coates, Anne Bobb, Walter A Koltun, Evangelos Messaris
AIM: Vedolizumab, a monoclonal antibody resulting in gut-selective anti-inflammatory activity, was FDA-approved in 2014 for use in patients with Crohn's disease (CD). The aim of the study was to investigate the efficacy of vedolizumab as a rescue therapy when other medical therapies have failed. METHOD: A retrospective review was performed on consecutive CD patients receiving vedolizumab between May 2014 and March 2016 at the Penn State Hershey IBD Center. These patients were unresponsive or intolerant to TNF antagonist therapy, and previously would have been surgical candidates...
April 19, 2018: Colorectal Disease: the Official Journal of the Association of Coloproctology of Great Britain and Ireland
https://www.readbyqxmd.com/read/29668929/chromoendoscopy-for-dysplasia-surveillance-in-inflammatory-bowel-disease
#11
Ann D Flynn, John F Valentine
Long-standing ulcerative colitis (UC) and extensive Crohn's colitis confer increased risk for development of colorectal cancer. Screening and surveillance colonoscopy programs aim to identify, resect, or detect dysplasia or colorectal cancer. Dysplastic lesions can be removed by endoscopic resection and patients with unresectable lesions can be referred for colectomy at an earlier stage, with the goal of reducing overall morbidity and mortality from colorectal cancer. Surveillance colonoscopy for patients with inflammatory bowel disease (IBD) is endorsed by multiple specialty societies...
April 13, 2018: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/29668922/circulating-and-fecal-micrornas-as-biomarkers-for-inflammatory-bowel-diseases
#12
Katharina Schönauen, Nha Le, Ulrike von Arnim, Christian Schulz, Peter Malfertheiner, Alexander Link
Background: Assessment of the disease activity in inflammatory bowel disease (IBD) is essential for adequate treatment management and reliable noninvasive biomarkers for verification of mucosal healing are still needed. MicroRNAs (miRNAs) are differentially expressed in IBD and cancer. We aimed to evaluate the potential of circulating and fecal miRNAs as diagnostic biomarkers for IBD. Methods: In this proof-of-principle study we used 2 independent patient cohorts...
April 12, 2018: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/29657828/an-objective-in-vivo-diagnostic-method-for-inflammatory-bowel-disease
#13
Sophie C Payne, Robert K Shepherd, Alicia Sedo, James B Fallon, John B Furness
Inflammatory damage to the bowel, as occurs in inflammatory bowel disease (IBD), is debilitating to patients. In both patients and animal experimental models, histological analyses of biopsies and endoscopic examinations are used to evaluate the disease state. However, such measurements often have delays and are invasive, while endoscopy is not quantitatively objective. Therefore, a real-time quantitative method to assess compromised mucosal barrier function is advantageous. We investigated the correlation of in vivo changes in electrical transmural impedance with histological measures of inflammation...
March 2018: Royal Society Open Science
https://www.readbyqxmd.com/read/29648663/incidence-and-classification-of-postcolonoscopy-colorectal-cancers-in-inflammatory-bowel-disease-a-dutch-population-based-cohort-study
#14
Dion S J Wintjens, Roel M M Bogie, Tim R A van den Heuvel, Chantal M C le Clercq, Liekele E Oostenbrug, Mariëlle J L Romberg-Camps, Jan-Willem Straathof, Laurents P S Stassen, Ad A M Masclee, Daisy M A E Jonkers, Silvia Sanduleanu-Dascalescu, Marie J Pierik
Background and Aims: Patients with inflammatory bowel disease (IBD) colitis are at increased risk for colorectal cancer (CRC). We examined the proportion and most likely aetiology of potentially preventable postcolonoscopy CRCs (PCCRCs) in a population-based cohort. Furthermore, adherence to IBD surveillance guidelines was evaluated in both PCCRCs and the remainder of prevalent CRCs. Methods: All IBD patients diagnosed from 1991 to 2011 in the South Limburg region of The Netherlands (i...
April 10, 2018: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/29644509/applications-of-colon-capsule-endoscopy
#15
REVIEW
Shabana F Pasha
PURPOSE OF REVIEW: This is a review of colon capsule endoscopy (CCE) with a focus on its recent developments, technological improvements, and current and potential future indications. RECENT FINDINGS: Based on the current literature, CCE II demonstrates comparable polyp detection rates as optical colonoscopy and CT colonography, and improved cost-effectiveness. The main limitation to patient acceptance is the requirement of a rigorous bowel preparation. Preliminary studies show good correlation between CCE and optical colonoscopy for assessment of colonic disease activity in inflammatory bowel disease (IBD)...
April 12, 2018: Current Gastroenterology Reports
https://www.readbyqxmd.com/read/29622900/unsuspected-small-bowel-crohn-s-disease-in-elderly-patients-diagnosed-by-video-capsule-endoscopy
#16
Che-Yung Chao, Carl Frederic Duchatellier, Ernest G Seidman
Background: Video capsule endoscopy (VCE) is increasingly performed among the elderly for obscure bleeding. Our aim was to report on the utility of VCE to uncover unsuspected Crohn's disease (CD) in elderly patients. Methods: Retrospective review of VCE performed in elderly patients (≥70 y) at a tertiary hospital (2010-2015). All underwent prior negative bidirectional endoscopies. CD diagnosis was based on consistent endoscopic findings, exclusion of other causes, and a Lewis endoscopic score (LS) > 790 (moderate-to-severe inflammation)...
2018: Diagnostic and Therapeutic Endoscopy
https://www.readbyqxmd.com/read/29610757/the-subtypes-of-microscopic-colitis-from-a-pathologist-s-perspective-past-present-and-future
#17
Peter Johan Heiberg Engel, Anne-Marie Kanstrup Fiehn, Lars Kristian Munck, Martin Kristensson
Microscopic colitis (MC) is a chronic inflammatory bowel disease, encompassing a triad of chronic diarrhea, normal endoscopy and characteristic histological findings. MC embraces two histological subtypes described as lymphocytic colitis (LC) and collagenous colitis (CC). The diagnostic criteria of MC were established several years ago and the histological description of LC and CC was based almost exclusively on heamatoxylin-eosin (HE) stained sections. Since the establishment of the diagnostic criteria, important changes have occurred in the concept and diagnostic methods of MC: the emergence of the entity "microscopic colitis incomplete" (MCi), comprising collagenous colitis incomplete (CCi) and lymphocytic colitis incomplete (LCi) and pathologists' increasing use of special stains in everyday diagnostics...
February 2018: Annals of Translational Medicine
https://www.readbyqxmd.com/read/29610731/microscopic-colitis-microbiome-barrier-function-and-associated-diseases
#18
REVIEW
Saskia van Hemert, Karolina Skonieczna-Żydecka, Igor Loniewski, Piotr Szredzki, Wojciech Marlicz
Microscopic colitis (MC) is a chronic inflammatory bowel disease (IBD) with little in terms of endoscopic abnormalities and is frequently associated with other autoimmune diseases. The peak incidence of the disease is in middle aged or older populations, mostly females. The pathogenesis of MC is complex, multifactorial and poorly understood. Current concepts revolve around innate immunity or microbiome alterations as well as gut barrier dysfunction, all of which lead to the development of subtle inflammatory lesions in gut mucosa...
February 2018: Annals of Translational Medicine
https://www.readbyqxmd.com/read/29608662/development-of-reliable-valid-and-responsive-scoring-systems-for-endoscopy-and-histology-in-animal-models-for-inflammatory-bowel-disease
#19
Pim J Koelink, Manon E Wildenberg, Larry W Stitt, Brian G Feagan, Martin Koldijk, Angélique B van 't Wout, Raja Atreya, Michael Vieth, Johannan F Brandse, Suzanne Duijst, Anje A Te Velde, Geert R A M D'Haens, Barrett G Levesque, Gijs R van den Brink
Background and Aims: Although several endoscopic and histopathologic indices are available to evaluate severity of inflammation in mouse models of colitis, the reliability of these scoring instruments is unknown. Our aim was to evaluate the reliability of the individual items in the existing indices and develop new scoring systems by selection of the most reliable index items. Methods: Two observers scored the histological slides (n=224) and endoscopy videos (n=201) from treated and untreated Interleukin(IL)-10 knock-out and T-cell transferred SCID mice...
March 28, 2018: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/29607052/changing-nationwide-trends-in-endoscopic-medical-and-surgical-admissions-for-inflammatory-bowel-disease-2003-2013
#20
Ahmir Ahmad, Anthony A Laverty, Chris Alexakis, Tom Cowling, Sonia Saxena, Azeem Majeed, Richard C G Pollok
Background and study aims: In the last decade, there have been major advances in inflammatory bowel disease (IBD) management but their impact on hospital admissions requires evaluation. We aim to investigate nationwide trends in IBD surgical/medical elective and emergency admissions, including endoscopy and cytokine inhibitor infusions, between 2003 and 2013. Patients and methods: We used Hospital Episode Statistics and population data from the UK Office for National Statistics...
2018: BMJ Open Gastroenterology
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