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https://www.readbyqxmd.com/read/27890853/chromoendoscopy-for-surveillance-in-ulcerative-colitis-and-crohn-s-disease-a-systematic-review-of-randomized-trials
#1
REVIEW
Andrea Iannone, Marinella Ruospo, Germaine Wong, Mariabeatrice Principi, Michele Barone, Giovanni Fm Strippoli, Alfredo Di Leo
BACKGROUND & AIMS: Key international guideline agencies recommend dysplasia surveillance in inflammatory bowel diseases with chromoendoscopy. We performed a systematic review of randomized trials comparing chromoendoscopy versus other endoscopic techniques for dysplasia surveillance in inflammatory bowel diseases. METHODS: We searched MEDLINE, EMBASE and Cochrane Central Register of Controlled Trials for relevant studies published through September 2016. We estimated risk ratios (RR) for dichotomous outcomes (all-cause/colorectal cancer-related mortality, time to interval cancer, patients with dysplasia, total/subtypes of dysplastic lesions, dysplasia detected by targeted biopsies, adverse events), mean differences (MD) for continuous outcomes (procedural time, costs, total/targeted biopsies) and their 95% confidence intervals (CI) using a random-effects model...
November 24, 2016: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/27885894/mr-enterography-of-inflammatory-bowel-disease-with-endoscopic-correlation
#2
Pankaj Kaushal, Alexander S Somwaru, Aline Charabaty, Angela D Levy
Crohn disease (CD) and ulcerative colitis (UC) are the two main forms of idiopathic inflammatory bowel disease (IBD). CD is a transmural chronic inflammatory disorder that can affect any part of the gastrointestinal tract in a discontinuous distribution. UC is a mucosal and submucosal chronic inflammatory disease that typically originates in the rectum and may extend proximally in a continuous manner. In treating patients with CD and UC, clinicians rely heavily on accurate diagnoses and disease staging. Magnetic resonance (MR) enterography used in conjunction with endoscopy and histopathologic analysis can help accurately diagnose and manage disease in the majority of patients...
November 25, 2016: Radiographics: a Review Publication of the Radiological Society of North America, Inc
https://www.readbyqxmd.com/read/27867950/review-capsule-colonoscopy-a-concise-clinical-overview-of-current-status
#3
REVIEW
Diana E Yung, Emanuele Rondonotti, Anastasios Koulaouzidis
The colon capsule endoscopy (CCE) was first introduced in 2007. Currently, the main clinical indications for CCE are completion of incomplete colonoscopy, polyp detection and investigation of inflammatory bowel disease (IBD). Although conventional colonoscopy is the gold standard in bowel cancer screening, incomplete colonoscopy remains a problem as lesions are missed. CCE compares favourably to computer tomography colonography (CTC) in adenoma detection and has therefore been proposed as a method for completing colonoscopy...
October 2016: Annals of Translational Medicine
https://www.readbyqxmd.com/read/27848960/endoscopy-chromoendoscopy-in-ibd-indispensable-in-real-life-screening
#4
Raja Atreya, Markus F Neurath
No abstract text is available yet for this article.
November 16, 2016: Nature Reviews. Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/27826994/diagnostic-efficacy-of-single-pass-abdominal-multidetector-row-ct-prospective-evaluation-of-a-low-dose-protocol
#5
Luigi Camera, Immacolata Liccardo, Federica Romano, Raffaele Liuzzi, Antonio Rispo, Massimo Imbriaco, Anna Testa, Gaetano Luglio, Simona De Fronzo, Fabiana Castiglione, Luigi Bucci, Arturo Brunetti
OBJECTIVES: To evaluate the diagnostic efficacy of single-pass contrast-enhanced multi-detector CT (CE-MDCT) performed with a low radiation-high contrast (LR-HC) dose protocol in selected patients with non traumatic acute bowel disease. METHODS: Sixty-five (32 M; 33 F; aged 20-67 years) consecutive patients with non traumatic acute bowel disease underwent single-pass CE-MDCT performed 70-100 sec after i.v. bolus injection of a non ionic iodinated contrast media (370 mgI/ml)...
November 9, 2016: British Journal of Radiology
https://www.readbyqxmd.com/read/27816496/advanced-endoscopy-imaging-in-inflammatory-bowel-diseases
#6
REVIEW
Ralf Kiesslich, Markus F Neurath
BACKGROUND AND AIMS: Rapid assessment of mucosal inflammation is of crucial importance for the initial diagnosis and the assessment of mucosal healing in inflammatory bowel diseases (IBD). Moreover, the identification of intraepithelial neoplasias in IBD is of key relevance for clinical management. Here, we systematically analyzed the utility of advanced endoscopic imaging techniques for optimized diagnosis in IBD. METHODS: PubMed/Medline, Web of Knowledge and Cochrane library were searched twice for diagnostic studies on advanced endoscopic imaging in IBD...
November 2, 2016: Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/27812393/primary-histoplasma-capsulatum-enterocolitis-mimicking-peptic-and-inflammatory-bowel-disease
#7
Rahman Nakshabendi, Andrew C Berry, Daisy Torres-Miranda, Francis Daniel LaBarbera, Ozdemir Kanar, Ahmad Nakshabandi, Imad Nakshabendi
In immunocompromised patients, histoplasmosis may present as disseminated disease. We present a 52-year-old Caucasian male with symptoms of dyspepsia, postprandial epigastric pain, nausea, and nonbloody diarrhea. Upper and lower gastrointestinal endoscopies were suspicious for inflammatory bowel disease (IBD); however, biopsies were consistent with histoplasmosis, specifically in the duodenum.
2016: Case Reports in Gastrointestinal Medicine
https://www.readbyqxmd.com/read/27808042/evaluation-of-confocal-laser-endomicroscopy-for-assessment-and-monitoring-of-therapeutic-response-in-patients-with-inflammatory-bowel-disease
#8
John Gásdal Karstensen
BACKGROUND: Crohn's disease (CD) and ulcerative colitis (UC) have been associated with altered intestinal barrier function. Moreover, it has been proposed that a defective barrier function is related to risk of relapse in patients with quiescent CD. Fluorescein-aided confocal laser endomicroscopy (CLE) is a novel endoscopic method, which enables real-time in vivo microscopy. Hence, the intestinal barrier function can be assessed as part of endoscopic evaluation of patients with inflammatory bowel disease (IBD) by measuring microerosions and fluorescein leakage into the intestinal lumen...
November 2016: Danish Medical Journal
https://www.readbyqxmd.com/read/27773807/outcomes-of-pregnancies-for-women-undergoing-endoscopy-while-they-were-pregnant-a-nationwide-cohort-study
#9
Jonas F Ludvigsson, Benjamin Lebwohl, Anders Ekbom, Ravi Kiran, Peter Hr Green, Jonas Höijer, Olof Stephansson
BACKGROUND & AIMS: Endoscopy is an integral part of the investigation and management of gastrointestinal disease. We aimed to examine outcomes of pregnancies for women who underwent endoscopy during their pregnancy. METHODS: We performed a nationwide population-based cohort study, linking data from the Swedish Medical Birth Registry (for births from 1992 through 2011) with those from the Swedish Patient Registry. We identified 3052 pregnancies exposed to endoscopy (2025 upper endoscopies, 1109 lower endoscopies, 58 endoscopic retrograde cholangiopancreatographies)...
October 20, 2016: Gastroenterology
https://www.readbyqxmd.com/read/27751880/advances-in-use-of-endoscopy-radiology-and-biomarkers-to-monitor-inflammatory-bowel-diseases
#10
Julian Panes, Vipul Jairath, Barrett G Levesque
Crohn's disease and ulcerative colitis are heterogeneous inflammatory bowel disease (IBD), and therapeutic requirements vary among patients. We have a limited capacity to predict disease progression for individual patients, so it is important that they are evaluated for presence of active disease when symptoms are mild or even absent, when patients are more likely to respond to new treatment interventions. It is then important to monitor responses to treatment, to quickly identify those therapies that are ineffective, modify or change therapy, and avoid disease complications...
October 14, 2016: Gastroenterology
https://www.readbyqxmd.com/read/27723123/faecal-biomarkers-in-inflammatory-bowel-disease
#11
Robert N Lopez, Steven T Leach, Daniel A Lemberg, Gilles Duvoisin, Richard B Gearry, Andrew S Day
Over the last two decades knowledge on faecal biomarkers has substantially increased. Nowadays these non-invasive markers of inflammation have significant clinical utility in the management of inflammatory bowel disease (IBD). Their use informs the decision to perform endoscopy before diagnosis is made right through to influencing therapeutic choices and the need for interval endoscopic assessment. In this review, the roles of two S100 proteins, calprotectin and S100A12 are described along with that of lactoferrin, in the context of IBD...
October 10, 2016: Journal of Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/27699005/calprotectin-as-a-diagnostic-tool-for-inflammatory-bowel-diseases
#12
Marianthi Chatzikonstantinou, Panagiotis Konstantopoulos, Spyros Stergiopoulos, Konstantinos Kontzoglou, Christos Verikokos, Despina Perrea, Dimitris Dimitroulis
Inflammatory bowel diseases (IBD) are chronic intestinal disorders caused by a number of factors, including external influences, intestinal microbiota and genetics. The two major clinically defined types of IBD are Crohn's disease and ulcerative colitis, each of which is characterized by relapses in the clinical course, thus patients must be under constant observation via regular endoscopies. As endoscopy, which has been used for direct evaluation and diagnosis of IBD, requires uncomfortable and expensive bowel preparation, a non-invasive test was required to reduce the number of patients undergoing unnecessary endoscopy...
October 2016: Biomedical Reports
https://www.readbyqxmd.com/read/27688654/inflammatory-bowel-disease-in-india-past-present-and-future
#13
REVIEW
Gautam Ray
There is rising incidence and prevalence of inflammatory bowel disease (IBD) in India topping the Southeast Asian (SEA) countries. The common genes implicated in disease pathogenesis in the West are not causal in Indian patients and the role of "hygiene hypothesis" is unclear. There appears to be a North-South divide with more ulcerative colitis (UC) in north and Crohn's disease (CD) in south India. IBD in second generation Indian migrants to the West takes the early onset and more severe form of the West whereas it retains the nature of its country of origin in migrants to SEA countries...
September 28, 2016: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/27669711/short-term-outcomes-of-a-novel-endoscopic-clipping-device-for-closure-of-the-internal-opening-in-100-anorectal-fistulas
#14
R L Prosst, A K Joos
BACKGROUND: One hundred consecutive applications of a new clipping device, the OTSC(®) Proctology (Ovesco Endoscopy AG), were analyzed to assess its efficacy for the treatment of complex anorectal fistulas. METHODS: In patients with anorectal fistulas, minimally invasive surgery with the OTSC(®) Proctology system was performed according to a standardized technique: the fistula tract was debrided using a special fistula brush, and the clip was applied on the internal fistula opening...
November 2016: Techniques in Coloproctology
https://www.readbyqxmd.com/read/27668227/pillcam-colon-capsule-endoscopy-pcce-in-colonic-diseases
#15
REVIEW
Dan Carter, Rami Eliakim
Diseases affecting the colon are common worldwide and can cause a major health problem. Colorectal cancer (CRC) as well as Inflammatory bowel diseases represent a major cause of morbidity and mortality in western countries. PillCam colon capsule endoscopy (PCCE) is a novel and promising technology that can be useful for the screening and monitoring of colonic diseases. In the recent years many articles examined the use of various versions of PCCE-the 1st and 2nd generation versus various other endoscopic or radiologic modalities both for detection of colonic polyps or cancer and in both ulcerative colitis (UC) and Crohn's disease...
August 2016: Annals of Translational Medicine
https://www.readbyqxmd.com/read/27666114/is-there-an-added-value-of-faecal-calprotectin-and-haemoglobin-in-the-diagnostic-work-up-for-primary-care-patients-suspected-of-significant-colorectal-disease-a-cross-sectional-diagnostic-study
#16
Sjoerd G Elias, Liselotte Kok, Niek J de Wit, Ben J M Witteman, Jelle G Goedhard, Mariëlle J L Romberg-Camps, Jean W M Muris, Karel G M Moons
BACKGROUND: The majority of primary care patients referred for bowel endoscopy do not have significant colorectal disease (SCD), and are - in hindsight - unnecessarily exposed to a small but realistic risk of severe endoscopy-associated complications. We developed a diagnostic strategy to better exclude SCD in these patients and evaluated the value of adding a faecal calprotectin point-of-care (POC) and/or a POC faecal immunochemical test for haemoglobin (FIT) to routine clinical information...
September 26, 2016: BMC Medicine
https://www.readbyqxmd.com/read/27652159/prevalence-of-amebiasis-in-inflammatory-bowel-disease-in-university-clinical-hospital-mostar
#17
Emil Babić, Milenko Bevanda, Mladen Mimica, Maja Karin, Mile Volarić, Ante Bogut, Tatjana Barišić, Danijel Pravdić, Nikica Šutalo
AIM: To explore the prevalence of amebiasis in inflammatory bowel disease (IBD), Crohn's disease and ulcerative colitis, in patients in Clinical hospital Mostar (Bosnia and Herzegovina, region of Herzegovina). METHODS: In this study, Entamoeba histolytica/dispar prevalence was investigated in fresh faeces by native microscopy and immunochromatographic rapid assay "RIDA(®)QUICK Entamoeba test", in 119 cases of new found IBD patients, 84 of ulcerative colitis and 35 of Crohn's disease and in control group who had also 119 patients who didn't have any gastrointestinal complaints...
2016: SpringerPlus
https://www.readbyqxmd.com/read/27651219/challenges-faced-by-cross-sectional-imaging-and-histological-endpoints-in-clinical-trials
#18
Vincenzo Villanacci, Filip Baert, Freddy Cornillie, Gert De Hertogh, Julián Panés
In patients with inflammatory bowel disease, a dissociation can occur between symptoms and presence of inflammatory lesions. This dissociation has led to the recognition that objective measures of disease activity together with clinical assessment should be co-primary endpoints in clinical trials. Objective assessment of inflammatory lesions has classically relied on ileocolonoscopy. However, examination with endoscopy cannot always be complete and does not evaluate transmural changes. Furthermore, histological alterations may persist in the presence of mild or even absent endoscopy lesions...
September 20, 2016: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/27651018/how-is-inflammatory-bowel-disease-managed-in-spanish-gastroenterology-departments-the-results-of-the-gestiona-eii-survey
#19
Manuel Barreiro-de Acosta, Federico Argüelles-Arias, Joaquín Hinojosa, Francisco Javier Júdez Gutiérrez, Jose Maria Tenías Burillo
INTRODUCTION: Not all national health centers include specialized units or clinicians devoted to inflammatory bowel disease. The goal of the survey was to gain an insight into the management of this disease within Spanish gastroenterology departments via a survey among their members. MATERIAL AND METHODS: An online survey was conducted in February and March 2015, among SEPD members (2017 clinician members), who were split into three categories: heads of department, general gastroenterologists, and experts in this disease...
October 2016: Revista Española de Enfermedades Digestivas
https://www.readbyqxmd.com/read/27641945/diagnostic-value-of-diffusion-weighted-imaging-dwi-for-the-assessment-of-the-small-bowel-in-patients-with-inflammatory-bowel-disease
#20
M L Hahnemann, A Dechene, S Kathemann, S Sirin, G Gerken, T C Lauenstein, S Kinner
AIM: To evaluate diffusion-weighted imaging (DWI) compared to standard magnetic resonance imaging (sMRI) in the assessment of inflammatory lesions of the small bowel. MATERIALS AND METHODS: Two readers retrospectively analysed MRI images of the small bowel including DWI followed by capsule endoscopy (CE) and ileocolonoscopy (ICS) in 30 consecutive patients with a suspected or established diagnosis of inflammatory bowel disease. Small bowel CE and the combination of CE + ICS were used as the standards of reference...
September 16, 2016: Clinical Radiology
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