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https://www.readbyqxmd.com/read/29164429/red-blood-cell-distribution-width-as-a-related-factor-of-pulmonary-arterial-hypertension-in-patients-with-systemic-sclerosis
#1
Jiuliang Zhao, Hongnan Mo, Xiaoxiao Guo, Qian Wang, Dong Xu, Yong Hou, Zhuang Tian, Yongtai Liu, Hui Wang, Jinzhi Lai, Mengtao Li, Xiaofeng Zeng
The aim of this study was to investigate the utility of red blood cell distribution width (RDW) as a simple and readily available marker of occurrence of pulmonary arterial hypertension (PAH) in patients with systemic sclerosis (SSc). One hundred and forty-five consecutive patients with SSc were recruited to the single-center cross-sectional study. Demographic characteristics, hematological parameters, Modified Rodnan Skin Score, and World Health Organization functional classification were determined. Diagnosis of PAH was based on screening by echocardiography and was confirmed by right heart catheterization...
November 21, 2017: Clinical Rheumatology
https://www.readbyqxmd.com/read/29163841/assessing-right-ventricular-function-in-pulmonary-hypertension-patients-and-the-correlation-with-the-new-york-heart-association-nyha-classification
#2
Xiaoke Shang, Shuna Xiao, Nianguo Dong, Rong Lu, Lijun Wang, Bin Wang, Yousan Chen, Liang Zhong, Mei Liu
This investigation aimed to compare the pressure-volume loop (PV loop) measurements in three less symptomatic categories (New York Heart Association classes , NYHA I, II, and III) of pulmonary hypertension (PH) patients since NYHA classification system performance is limited by the shortcomings discussed above. Thirty-six patients were enrolled in this study with PV loop measurement acquisition via micro-conductance catheters. Functional classification according to NYHA was determined with comprehensive assessing function and activity...
October 27, 2017: Oncotarget
https://www.readbyqxmd.com/read/29158679/treatment-of-pulmonary-hypertension-with-left-heart-disease-a-concise-review
#3
REVIEW
Anish Desai, Shilpa A Desouza
Pulmonary hypertension (PH) is defined by a mean pulmonary artery pressure ≥ 25 mmHg, as determined by right heart catheterization. Pulmonary arterial hypertension (PAH) can no longer be considered an orphan disease given the increase in awareness and availability of new drugs. PH carries with it a dismal prognosis and leads to significant morbidity and mortality. Symptoms can range from dyspnea, fatigue and chest pain to right ventricular failure and death. PH is divided into five groups by the World Health Organization (WHO), based on etiology...
2017: Vascular Health and Risk Management
https://www.readbyqxmd.com/read/29148140/haemodynamic-effects-of-an-acute-vasodilator-challenge-in-heart-failure-patients-with-reduced-ejection-fraction-and-different-forms-of-post-capillary-pulmonary-hypertension
#4
Stefano Ghio, Gabriele Crimi, Pier Luigi Temporelli, Egidio Traversi, Maria Teresa La Rovere, Antonia Cannito, Dario Vizza, Laura Scelsi, Claudia Raineri, Marco Guazzi, Luigi Oltrona Visconti
AIMS: The most recent European guidelines have proposed new definitions of pulmonary hypertension (PH) in left heart disease, to better approach the characteristics required to reflect the presence of pulmonary vascular disease. The purpose of this study was to assess whether different haemodynamic definitions of post-capillary PH imply a different reversibility of PH in response to acute vasodilator administration in heart failure patients with reduced ejection fraction and PH (HFrEF-PH)...
November 16, 2017: European Journal of Heart Failure
https://www.readbyqxmd.com/read/29143104/left-ventricular-end-diastolic-dimension-and-septal-e-are-predictors-of-cardiac-index-at-rest-while-tricuspid-annular-plane-systolic-excursion-is-a-predictor-of-peak-oxygen-uptake-in-patients-with-pulmonary-hypertension
#5
Yoshihisa Nakano, Naoki Okumura, Shiro Adachi, Shigetake Shimokata, Fumitaka Tajima, Yoshihiro Kamimura, Toyoaki Murohara, Takahisa Kondo
Little is known regarding a correlation of hemodynamics at rest or exercise capacity with echocardiographic parameters in patients with pulmonary hypertension (PH). To clarify these potential correlations, we performed transthoracic echocardiography, right heart catheterization, and cardiopulmonary exercise testing in 53 patients with pulmonary arterial hypertension (PAH) and chronic thromboembolic pulmonary hypertension (CTEPH). Left ventricular end-diastolic dimension (LVDd), early diastolic velocity of the septal mitral annulus (septal e'), tricuspid regurgitation peak gradient (TRPG), and tricuspid annular plane systolic excursion (TAPSE) were significantly correlated with cardiac index (LVDd; r = 0...
November 15, 2017: Heart and Vessels
https://www.readbyqxmd.com/read/29142816/unilateral-pulmonary-edema-in-a-patient-with-worsening-tricuspid-valve-regurgitation-a-secret-inside-pulmonary-veins
#6
Elvira Resciniti, Ilaria Caso, Iside Scarfò, Giuseppe Di Pasquale, Giovanni La Canna
We present the case of a 69-year-old patient who was referred to the Department of Echocardiography for surgical treatment of severe tricuspid valve regurgitation (TVR) with advanced congestive heart failure. In 2013 the patient underwent unsuccessful percutaneous ablation for permanent atrial fibrillation. In 2015, following numerous episodes of atrial fibrillation and congestive heart failure with left pleural effusion, the patient was admitted to another center. A transthoracic echocardiogram showed severe TVR and moderate precapillary pulmonary hypertension, confirmed at right cardiac catheterization...
October 2017: Journal of Cardiovascular Echography
https://www.readbyqxmd.com/read/29140312/plasma-amino-acid-abnormalities-in-chronic-heart-failure-mechanisms-potential-risks-and-targets-in-human-myocardium-metabolism
#7
Roberto Aquilani, Maria Teresa La Rovere, Daniela Corbellini, Evasio Pasini, Manuela Verri, Annalisa Barbieri, Anna Maria Condino, Federica Boschi
The goal of this study was to measure arterial amino acid levels in patients with chronic heart failure (CHF), and relate them to left ventricular function and disease severity. Amino acids (AAs) play a crucial role for heart protein-energy metabolism. In heart failure, arterial AAs, which are the major determinant of AA uptake by the myocardium, are rarely measured. Forty-one subjects with clinically stable CHF (New York Heart Association (NYHA) class II to IV) were analyzed. After overnight fasting, blood samples from the radial artery were taken to measure AA concentrations...
November 15, 2017: Nutrients
https://www.readbyqxmd.com/read/29126717/2013-acr-eular-systemic-sclerosis-classification-criteria-in-patients-with-associated-pulmonary-arterial-hypertension
#8
Beatriz E Joven, Pilar Escribano, Jose Luis Andreu, Estibaliz Loza, Carmen Jimenez, M Jesus Garcia de Yebenes, M Jose Ruiz-Cano, Loreto Carmona, Patricia E Carreira
OBJECTIVE: To analyze the performance of the 1980 ACR and new 2013 ACR/EULAR criteria for systemic sclerosis (SSc) in cutaneous SSc (lcSSc) patients, especially those affected by lcSSc and pulmonary arterial hypertension (PAH). METHODS: All patients with a clinical lcSSc diagnosis from a prospective observational SSc cohort were included. Sociodemographic and disease-related variables were collected, and PAH confirmed by right heart catheterization (RHC). Performance of the 2013 and 1980 SSc criteria was analyzed in terms of clinical diagnosis...
October 13, 2017: Seminars in Arthritis and Rheumatism
https://www.readbyqxmd.com/read/29121971/cmr-based-blood-oximetry-via-multi-parametric-estimation-using-multiple-t2-measurements
#9
Juliet Varghese, Lee C Potter, Richard LaFountain, Xueliang Pan, Subha V Raman, Rizwan Ahmad, Orlando P Simonetti
BACKGROUND: Measurement of blood oxygen saturation (O2 saturation) is of great importance for evaluation of patients with many cardiovascular diseases, but currently there are no established non-invasive methods to measure blood O2 saturation in the heart. While T2-based CMR oximetry methods have been previously described, these approaches rely on technique-specific calibration factors that may not generalize across patient populations and are impractical to obtain in individual patients...
November 9, 2017: Journal of Cardiovascular Magnetic Resonance
https://www.readbyqxmd.com/read/29118889/successful-treatment-of-iatrogenic-external-iliac-artery-perforation-with-covered-stent-case-report-and-review-of-the-literature
#10
Muhammad Umer Awan, Bassam Omar, Ghazanfar Qureshi, Ghulam Mustafa Awan
Retroperitoneal hemorrhage from iliac artery injury is a potentially serious complication of vascular interventional procedures leading to hemorrhagic shock and death if not diagnosed early and treated promptly. We report a 70-year-old male admitted to our facility with non-ST-elevation myocardial infarction, whose heart catheterization revealed left anterior descending artery (LAD) with 80% proximal, 95% mid and 100% distal disease. The left circumflex and right coronary arteries were 100% occluded proximally and received collaterals from the LAD...
October 2017: Cardiology Research
https://www.readbyqxmd.com/read/29117041/repeated-ramp-tests-on-stable-lvad-patients-reveal-patient-specific-hemodynamic-fingerprint
#11
Teruhiko Imamura, Daniel Burkhoff, Daniel Rodgers, Sirtaz Adatya, Nitasha Sarswat, Gene Kim, Jayant Raikhelkar, Takeyoshi Ota, Tae Song, Colleen Juricek, Valluvan Jeevanandam, Gabriel Sayer, Nir Uriel
Hemodynamic speed ramp tests are used in left ventricular assist device (LVAD) patients to guide speed adjustment and medical therapies. However, the reproducibility of these tests is unknown. In this prospective study, clinically stable LVAD patients underwent echocardiography and right heart catheterization ramp tests followed by a repeat test within 2 years as per institutional protocol. Sixteen patients (61.8 ± 10.5 years old, 50% male, eight with HeartMate II and eight with HVAD) underwent repeated ramp testing...
November 7, 2017: ASAIO Journal: a Peer-reviewed Journal of the American Society for Artificial Internal Organs
https://www.readbyqxmd.com/read/29114731/association-of-cardiac-hemodynamic-factors-with-severity-of-white-matter-hyperintensities-in-chronic-valvular-heart-disease
#12
Woo-Jin Lee, Keun-Hwa Jung, Young Jin Ryu, Jeong-Min Kim, Soon-Tae Lee, Kon Chu, Manho Kim, Sang Kun Lee, Jae-Kyu Roh
Importance: The cerebral white matter hyperintensity (WMH) is frequently noted in patients with chronic heart disease. Long-term alteration of cardiac hemodynamics might have an influence on the mechanism of cerebral WMH. Objective: To investigate the association between chronically altered cardiac hemodynamics and severity of cerebral WMH in patients with chronic valvular heart disease. Design, Setting, and Participants: This cross-sectional analysis identified 303 consecutive patients at a tertiary referral center between 2008 and 2016 who were 50 years or older, and diagnosed with severe chronic valvular heart disease and underwent cardiac catherization, echocardiography, and received brain magnetic resonance imaging...
November 6, 2017: JAMA Neurology
https://www.readbyqxmd.com/read/29107544/prognostic-relevance-of-right-heart-reverse-remodeling-in-idiopathic-pulmonary-arterial-hypertension
#13
Roberto Badagliacca, Roberto Poscia, Beatrice Pezzuto, Silvia Papa, Manuela Reali, Francesca Pesce, Giovanna Manzi, Daniele Gianfrilli, Francesco Ciciarello, Susanna Sciomer, Giuseppe Biondi-Zoccai, Roberto Torre, Francesco Fedele, Carmine Dario Vizza
BACKGROUND: Right ventricular (RV) failure is a major determinant of symptoms and shortened survival in pulmonary arterial hypertension (PAH). This study assessed the prognostic relevance of increased right heart (RH) dimensions determined by echocardiography and RH reverse remodeling (RHRR) with targeted therapies in idiopathic PAH (IPAH). METHODS: The study prospectively monitored 102 therapy-naïve IPAH patients for the presence of clinical worsening. Baseline evaluation included RH catheterization and echocardiography...
October 2, 2017: Journal of Heart and Lung Transplantation
https://www.readbyqxmd.com/read/29103472/performance-of-computed-tomography-derived-pulmonary-vasculature-metrics-in-the-diagnosis-and-haemodynamic-assessment-of-pulmonary-arterial-hypertension
#14
Kaoruko Shimizu, Ichizo Tsujino, Takahiro Sato, Ayako Sugimoto, Toshitaka Nakaya, Taku Watanabe, Hiroshi Ohira, Yoichi M Ito, Masaharu Nishimura
BACKGROUND: Few studies have addressed the value of combining computed tomography-derived pulmonary vasculature metrics for the diagnosis and haemodynamic evaluation of pulmonary arterial hypertension (PAH). MATERIALS AND METHODS: We measured three computed tomography parameters for the pulmonary artery, peripheral vessels, and pulmonary veins: the ratio of the diameter of the pulmonary artery to the aorta (PA/Ao), the cross-sectional area of small pulmonary vessels <5mm(2) as a percentage of total lung area (%CSA<5), and the diameter of the right inferior pulmonary vein (PVD)...
November 2017: European Journal of Radiology
https://www.readbyqxmd.com/read/29101270/balloon-pulmonary-angioplasty-for-chronic-thromboembolic-pulmonary-hypertension-results-of-a-multicenter-registry
#15
Aiko Ogawa, Toru Satoh, Tetsuya Fukuda, Koichiro Sugimura, Yoshihiro Fukumoto, Noriaki Emoto, Norikazu Yamada, Atsushi Yao, Motomi Ando, Hitoshi Ogino, Nobuhiro Tanabe, Ichizo Tsujino, Masayuki Hanaoka, Kenji Minatoya, Hiroshi Ito, Hiromi Matsubara
BACKGROUND: Balloon pulmonary angioplasty (BPA) is an alternative therapy for patients with chronic thromboembolic pulmonary hypertension who are ineligible for pulmonary endarterectomy-the standard therapy. Currently, most reported results of BPA are from relatively small cohorts treated at single centers. The present study evaluated the safety and efficacy of BPA for chronic thromboembolic pulmonary hypertension based on a multicenter registry. METHODS AND RESULTS: A total of 308 patients (62 men and 246 women; mean age, 61 years) underwent 1408 procedures at 7 institutions in Japan...
November 2017: Circulation. Cardiovascular Quality and Outcomes
https://www.readbyqxmd.com/read/29093153/limited-exercise-capacity-in-patients-with-systemic-sclerosis-identifying-contributing-factors-with-cardiopulmonary-exercise-testing
#16
Nihal Martis, Viviane Queyrel-Moranne, David Launay, Rémi Neviere, Jean-Gabriel Fuzibet, Charles-Hugo Marquette, Sylvie Leroy
OBJECTIVE: Exercise limitation in patients with systemic sclerosis (SSc) is often multifactorial and related to complications such as interstitial lung disease (ILD), pulmonary vasculopathy (PV), left ventricular dysfunction (LVD), and/or peripheral/muscular limitation (PML). We hypothesized that cardiopulmonary exercise testing (CPET) could not only suggest and rank competing etiologies, but also highlight peripheral impairment. METHODS: Clinical, resting pulmonary function testing, and CPET data from patients with SSc referred for exercise limitation between October 2009 and November 2015 were retrospectively analyzed in this bi-center study...
November 1, 2017: Journal of Rheumatology
https://www.readbyqxmd.com/read/29089339/wave-intensity-analysis-provides-novel-insights-into-pulmonary-arterial-hypertension-and-chronic-thromboembolic-pulmonary-hypertension
#17
Junjing Su, Charlotte Manisty, Kim H Parker, Ulf Simonsen, Jens Erik Nielsen-Kudsk, Soren Mellemkjaer, Susan Connolly, P Boon Lim, Zachary I Whinnett, Iqbal S Malik, Geoffrey Watson, Justin E Davies, Simon Gibbs, Alun D Hughes, Luke Howard
BACKGROUND: In contrast to systemic hypertension, the significance of arterial waves in pulmonary hypertension (PH) is not well understood. We hypothesized that arterial wave energy and wave reflection are augmented in PH and that wave behavior differs between patients with pulmonary arterial hypertension (PAH) and chronic thromboembolic pulmonary hypertension (CTEPH). METHODS AND RESULTS: Right heart catheterization was performed using a pressure and Doppler flow sensor-tipped catheter to obtain simultaneous pressure and flow velocity measurements in the pulmonary artery...
October 31, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29082512/cardiopulmonary-exercise-test-predicts-right-heart-catheterization
#18
Michele Correale, Lucia Tricarico, Armando Ferraretti, Ilenia Monaco, Morena Concilio, Giuseppina Padovano, Gianfranco Acanfora, Matteo Di Biase, Natale Daniele Brunetti
BACKGROUND: Right heart catheterization (RHC) is usually required to confirm the diagnosis of pulmonary artery hypertension (PAH). As an invasive test, RHC may be associated with possible complications; so, non-invasive parameters able to predict PAH at RHC would be extremely useful. AIM: To ascertain possible correlations between cardiopulmonary exercise testing (CPET) and hemodynamic parameters at RHC indicative of PH. METHODS: Thirty-six consecutive outpatients with suspect of PAH underwent CPET and RHC; the intercept of ventilation (VEint) on the VE vs...
October 30, 2017: European Journal of Clinical Investigation
https://www.readbyqxmd.com/read/29077657/does-portopulmonary-hypertension-impede-liver-transplantation-in-cirrhotic-patients-a-french-multicentric-retrospective-study
#19
Maud Reymond, Louise Barbier, Ephrem Salame, Camille Besh, Jerome Dumortier, Georges-Philippe Pageaux, Christophe Bureau, Sébastien Dharancy, Claire Vanlemmens, Armand Abergel, Marie-Lorraine Woehl Jaegle, Pascal Magro, Frederic Patat, Emeline Laurent, Jean-Marc Perarnau
BACKGROUND: Portopulmonary hypertension is defined by the presence of pulmonary arterial hypertension associated with portal hypertension. Its presence is a major stake for cirrhotic patients requiring liver transplantation, with increased postoperative mortality and unpredictable evolution after transplantation. The aim was to study outcomes after liver transplantation in patients with portopulmonary hypertension and to identify factors associated with normalization of pulmonary hypertension...
October 26, 2017: Transplantation
https://www.readbyqxmd.com/read/29077636/effects-of-sedentary-aging-and-lifelong-exercise-on-left-ventricular-systolic-function
#20
Erin J Howden, Graeme Carrick-Ranson, Satyam Sarma, Michinari Hieda, Naoki Fujimoto, Benjamin D Levine
PURPOSE: The current study examined whether age-related changes in left ventricular (LV) longitudinal systolic function is an adaptation to a more sedentary lifestyle and can be preserved by lifelong exercise training. METHODS: A cross-sectional examination of 18 sedentary young (37±6 years), 29 sedentary seniors (71±5 years, 0-3 exercise sessions/wk), and 26 seniors (68±5 years) who had performed a committed level (4-7 exercise sessions/wk) of lifelong (>25 years) exercise...
October 26, 2017: Medicine and Science in Sports and Exercise
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