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https://www.readbyqxmd.com/read/28528325/merits-of-invasive-strategy-in-diabetic-patients-with-non-st-elevation-acute-coronary-syndrome
#1
EDITORIAL
Hani Jneid
No abstract text is available yet for this article.
May 20, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/28516369/management-of-elderly-patients-with-a%C3%A2-non-st-segment-elevation-acute-coronary-syndrome
#2
REVIEW
M E Gimbel, J M Ten Berg
Elderly patients with an acute coronary syndrome are underrepresented in randomised controlled trials. Neither the European Society of Cardiology nor the American Heart Association/American College of Cardiology acute coronary syndrome guidelines provide specific recommendations for elderly patients. However, elderly patients are at higher thrombotic and bleeding risk compared with younger patients leading to difficulties in choosing the optimal treatment. In this review, we discuss the uncertainties we encounter in treating elderly patients with non-ST-elevation acute coronary syndrome and suggest treatment options based on the existing literature...
May 17, 2017: Netherlands Heart Journal
https://www.readbyqxmd.com/read/28515099/temporal-biomarker-profiling-reveals-longitudinal-changes-in-risk-of-death-or-myocardial-infarction-in-non-st-segment-elevation-acute-coronary-syndrome
#3
Mark Chan, Megan L Neely, Matthew T Roe, Shaun G Goodman, David Erlinge, Jan H Cornel, Kenneth J Winters, Joseph A Jakubowski, Chunmei Zhou, Keith A A Fox, Paul W Armstrong, Harvey D White, Dorairaj Prabhakaran, E Magnus Ohman, Kurt Huber
BACKGROUND: There are conflicting data on whether changes in N-terminal pro-B-type natriuretic peptide (NT-proBNP) and high-sensitivity C-reactive protein (hs-CRP) concentrations between time points (delta NT-proBNP and hs-CRP) are associated with a change in prognosis. METHODS: We measured NT-proBNP and hs-CRP at 3 time points in 1665 patients with non-ST-segment elevation acute coronary syndrome (NSTEACS). Cox proportional hazards was applied to the delta between temporal measurements to determine the continuous association with cardiovascular events...
May 17, 2017: Clinical Chemistry
https://www.readbyqxmd.com/read/28515027/early-versus-delayed-invasive-strategies-in-high-risk-non-st-elevation-acute-coronary-syndrome-patients-a-systematic-literature-review-and-meta-analysis-of-randomised-controlled-trials
#4
REVIEW
Delara Javat, Clare Heal, Stefan Buchholz, Zhihua Zhang
RATIONALE: It is unclear whether it is beneficial to perform angiography and/or percutaneous coronary intervention (PCI) as an early or delayed invasive strategy amongst high-risk non-ST elevation acute coronary syndrome (NSTEACS) patients. OBJECTIVE: To determine whether an early invasive strategy could further reduce recurrent myocardial infarction (MI) and early mortality compared to a delayed invasive strategy. METHODS AND RESULTS: We searched MEDLINE, CINAHL and SCOPUS and performed a meta-analysis of nine RCTs with a total of 5274 patients...
April 11, 2017: Heart, Lung & Circulation
https://www.readbyqxmd.com/read/28514396/-long-term-results-of-different-approaches-to-revascularization-in-non-st-segment-elevation-acute-coronary-syndrome-and-multiple-coronary-atherosclerosis
#5
V I Ganyukov, R S Tarasov, Yu N Neverova, N A Kochergin, O L Barbarash, L S Barbarash
AIM: To assess the long-term results of different approaches to treating patients with non-ST-segment elevation acute coronary syndrome (NSTE ACS) and multivessel coronary artery disease (MVCAD). SUBJECTS AND METHODS: A total of 150 patients with NSTE ACS, in whom coronary angiography revealed MVCAD, were examined. The patients were divided into 3 groups according to the selected treatment policy: 1) percutaneous coronary intervention (PCI) (n=91 (60.6%)); 2) coronary artery bypass grafting (CABG) (n=40 (26...
2017: Terapevticheskiĭ Arkhiv
https://www.readbyqxmd.com/read/28511320/-guideline-and-consensus-for-the-management-of-patients-with-non-st-elevation-acute-coronary-syndrome-2016
#6
(no author information available yet)
No abstract text is available yet for this article.
May 24, 2017: Zhonghua Xin Xue Guan Bing za Zhi
https://www.readbyqxmd.com/read/28509568/low-body-weight-and-clinical-outcomes-in-acute-coronary-syndrome-patients-results-of-the-achilles-registry
#7
José Miguel Rivera-Caravaca, Juan M Ruiz-Nodar, Antonio Tello-Montoliu, María Asunción Esteve-Pastor, Andrea Veliz-Martínez, Esteban Orenes-Piñero, Mariano Valdés, Vicente Pernias-Escrig, Miriam Sandin-Rollán, Nuria Vicente-Ibarra, Manuel J Macías-Villanego, Elena Candela-Sánchez, Teresa Lozano, Luna Carrillo-Alemán, Francisco Marín
BACKGROUND: Being overweight increases the risk of cardiovascular diseases and mortality. However, among high-body-weight patients with established acute coronary syndrome (ACS) this evidence is not clear. In this scenario, a low body weight (LBW) has been proposed to confer higher prognostic risk and higher bleeding risk with new P2Y12 inhibitors. AIMS: We aimed to examine differences in mortality, catheterizations/revascularizations, antiplatelet therapy and ischemic/bleeding adverse events between ACS patients with LBW...
May 1, 2017: European Journal of Cardiovascular Nursing
https://www.readbyqxmd.com/read/28504219/one-year-clinical-results-of-the-italian-diffuse-multivessel-disease-absorb-prospective-registry-it-disappears
#8
Luca Testa, Marco De Carlo, Alessandro Petrolini, Claudio Rapetto, Ferdinando Varbella, Bernardo Cortese, Gabriele Gabrielli, Salvatore Geraci, Bruno Loi, Giacomo Boccuzzi, Giuseppe Tarantini, Daniela Fischetti, Paolo Calabria, Fabrizio Tomai, Flavio Ribichini, Corrado Tamburino, Ciro Indolfi, Antonio L Bartorelli, Anna Sonia Petronio, Francesco Bedogni
AIMS: The present multicentre prospective study, IT-DISAPPEARS, was designed with the aim of evaluating early and long-term clinical outcomes of the Absorb BVS in patients with long coronary lesions and/or multivessel coronary artery disease. The aim of this article is to present the one-year clinical results of this study. METHODS AND RESULTS: Between November 2014 and January 2016, we enrolled 1,002 patients undergoing BVS implantation (long lesion [≥ 24 mm] of a single vessel in 80...
May 16, 2017: EuroIntervention
https://www.readbyqxmd.com/read/28497565/transient-left-ventricular-outflow-tract-obstruction-with-systolic-anterior-motion-of-the-mitral-valve-a-stunning-cause
#9
Christiaan L Meuwese, Mohamed Boulaksil, Jeroen van Dijk, Jawed Polad, Huub W Meijburg
Left ventricular outflow tract obstruction (LVOTO) and systolic anterior motion (SAM) of the mitral valve may have various etiologies, of which hypertrophic cardiomyopathy is the most common. More rarely, an acute coronary syndrome, myocardial stunning, and takotsubo cardiomyopathy may give rise to LVOTO and SAM. Here, we present a 70-year-old female patient with a non-ST-elevation acute coronary syndrome treated with percutaneous coronary intervention. Echocardiography the day after, because of dyspnea and hypotension, revealed apical akinesia, LVOTO, and SAM, which proved completely reversible after treatment with a β-blocker and a 2-month follow-up period...
May 12, 2017: Echocardiography
https://www.readbyqxmd.com/read/28491083/comparison-of-the-performance-of-the-crusade-acuity-horizons-and-action-bleeding-scores-in-acs-patients-undergoing-pci-insights-from-a-cohort-of-4939-patients-in-china
#10
Ran Liu, Shu-Zheng Lyu, Guan-Qi Zhao, Wen Zheng, Xiao Wang, Xue-Dong Zhao, Sheng-Hui Zhou, Lei Zhen, Shao-Ping Nie
BACKGROUND: The CRUSADE, ACTION and ACUITY-HORIZONS scores are commonly used for predicting in-hospital major bleeding events in patients with acute coronary syndrome (ACS), but the homogeneous nature of these models' population limits simple extrapolation to other local population. We aimed to compare the performance of the three risk models in Chinese patients. METHODS: We evaluated the performance of the three predicting scores for predicting in-hospital major bleeding events defined by thrombolysis in myocardial infarction (TIMI) serious (major and minor) episodes, in a cohort of Chinese ACS patients with either non-ST-elevation ACS (NSTE-ACS) or ST-elevation myocardial infarction (STEMI)...
February 2017: Journal of Geriatric Cardiology: JGC
https://www.readbyqxmd.com/read/28490313/radial-vs-femoral-approach-in-acute-coronary-syndromes-a-comprehensive-meta-analysis-of-randomized-trials
#11
Matteo Nardin, Monica Verdoia, Lucia Barbieri, Alon Schaffer, Harry Suryapranata, Giuseppe De Luca
BACKGROUND: Substantial improvements have been achieved with percutaneous coronary intervention (PCI) for the treatment of acute coronary syndromes (ACS). Nevertheless, bleeding still affects outcomes. The radial approach for PCI has shown important benefits on access site complications, but is still not achieving universal consensus as first choice in acute settings. Therefore, we performed a comprehensive meta-analysis of randomized trials comparing radial vs femoral approach in PCI for ACS...
May 4, 2017: Current Vascular Pharmacology
https://www.readbyqxmd.com/read/28487035/radial-versus-femoral-access-for-the-treatment-of-left%C3%A2-main-lesion-in-the-era-of-second-generation-drug-eluting-stents
#12
Sebastiano Gili, Fabrizio D'Ascenzo, Roberto Di Summa, Federico Conrotto, Enrico Cerrato, Alaide Chieffo, Giacomo Boccuzzi, Antonio Montefusco, Fabrizio Ugo, Pierluigi Omedé, Hiroyoshi Kawamoto, Francesco Tomassini, Marco Pavani, Ferdinando Varbella, Roberto Garbo, Maurizio D'Amico, Giuseppe Biondi Zoccai, Claudio Moretti, Javier Escaned, Antonio Colombo, Fiorenzo Gaita
Transradial access (TRA) is often avoided in favor of the transfemoral access (TFA) during percutaneous coronary interventions of the unprotected left main coronary artery (ULM), due to technical and safety concerns. The aim of this study was to compare the performance of TRA and TFA in the treatment of ULM with second-generation drug-eluting stents. Consecutive patients who underwent percutaneous coronary intervention on ULM with second-generation drug-eluting stents were retrospectively enrolled in the multicenter Failure in Left Main Study With 2nd Generation Stents (FAILS 2) registry...
April 12, 2017: American Journal of Cardiology
https://www.readbyqxmd.com/read/28482804/choosing-between-enoxaparin-and-fondaparinux-for-the-management-of-patients-with-acute-coronary-syndrome-a-systematic-review-and-meta-analysis
#13
Pravesh Kumar Bundhun, Musaben Shaik, Jun Yuan
BACKGROUND: Enoxaparin and Fondaparinux are potential anticoagulants which are used peri-operatively in the management of patients with Acute Coronary Syndrome (ACS). We aimed to compare the adverse clinical outcomes which are associated with the use of these anticoagulants in patients who were treated for ACS. METHODS: Online databases (PubMed/Medline, EMBASE, Cochrane library) were searched for studies which compared differences in clinical outcomes observed with the use of enoxaparin and fondaparinux in patients who were treated peri-operatively for ACS...
May 8, 2017: BMC Cardiovascular Disorders
https://www.readbyqxmd.com/read/28476519/the-underutilisation-of-dual-antiplatelet-therapy-in-acute-coronary-syndrome
#14
Malcolm Anastasius, Jerrett K Lau, Karice Hyun, Mario D'Souza, Anushka Patel, Jamie Rankin, Darren Walters, Craig Juergens, Bernadette Aliprandi-Costa, Andrew T Yan, Shaun G Goodman, Derek Chew, David Brieger
BACKGROUND: Despite guideline recommendation of dual antiplatelet therapy (DAPT) in treating ACS, DAPT is underutilized. Our objective was to determine independent predictors of DAPT non-prescription in ACS and describe pattern of DAPT prescription over time. METHODS: Patients presenting to 41 Australian hospitals with an ACS diagnosis between 2009 and 2016 were stratified according to discharge prescription with DAPT and single antiplatelet therapy (SAPT) or no antiplatelet therapy...
April 25, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28475171/relationship-between-infarct-artery-location-acute-total-coronary-occlusion-and-mortality-in-stemi-and-nstemi-patients
#15
Jarosław Karwowski, Marek Gierlotka, Mariusz Gąsior, Lech Poloński, Jan Ciszewski, Maciej Bęćkowski, Ilona Kowalik, Hanna Szwed
INTRODUCTION    Prevalence and impact of total coronary occlusion of an infarct-related artery (IRA) on outcome could be different between patients with Non-ST-Elevation Myocardial Infarction (NSTEMI) and ST-segment elevation myocardial infarction (STEMI) undergoing percutaneous coronary intervention (PCI). OBJECTIVES    We evaluated the impact of IRA occlusion on outcome of myocardial infarction, according to the presence or absence of ST-segment elevation and the culprit lesion location. PATIENTS AND METHODS    We analyzed 4581 STEMI patients and 2717 NSTEMI patients enrolled in the Polish Registry of Acute Coronary Syndromes who underwent PCI...
May 5, 2017: Polish Archives of Internal Medicine
https://www.readbyqxmd.com/read/28473918/vasospastic-myocardial-infarction-caused-by-a-slimming-agent-do-not-forget-non-prescription-drugs
#16
Mohammed Omer Anwar, Neil Bodagh, Mohammed Husnain Iqbal, Adam Timmis
A 41-year-old woman presented with central chest discomfort. She had been previously well, was an ex-smoker and reported no regular medication. The ECG developed T-wave changes inferiorly and anterolaterally and troponin I concentrations were elevated confirming non-ST elevation myocardial infarction. Cardiac catheterization showed severe spasm of the right and left anterior descending coronary arteries which resolved with intracoronary nitrates. She later volunteered that prior to presentation she had been taking non-prescription Acti-Phen a slimming agent containing phentermine...
April 2017: Oxford Medical Case Reports
https://www.readbyqxmd.com/read/28462421/comparative-effectiveness-of-routine-invasive-coronary-angiography-for-managing-unstable-angina
#17
Sara Vogrin, Richard Harper, Elizabeth Paratz, Andrew MacIsaac, Jodie Burchell, Belinda Smith, Anthony Scott, Jongsay Yong, Vijaya Sundararajan
Background: Non-ST-segment elevation acute coronary syndromes include unstable angina and non-ST-segment elevation myocardial infarction. Most randomized controlled trials of routine versus selective invasive coronary angiography have high rates of crossover from control to intervention groups and do not include subgroup analysis for unstable angina. Consequently, no clear, specific recommendations exist regarding the use of angiography in unstable angina. Objective: To assess the effect of angiography on mortality in unstable angina, incorporating the results of additional cardiac procedures and events...
May 2, 2017: Annals of Internal Medicine
https://www.readbyqxmd.com/read/28460769/premature-coronary-artery-disease-in-india-coronary-artery-disease-in-the-young-cady-registry
#18
S S Iyengar, Rajiv Gupta, Sandhya Ravi, Saral Thangam, Thomas Alexander, C N Manjunath, R Keshava, C B Patil, Annie Sheela, J P S Sawhney
BACKGROUND: Coronary artery disease (CAD) occurs at younger age in India but only a limited number of studies have evaluated risk factors and management status. This is a multisite observational registry to assess risk factors and treatment patterns in young patients presenting with acute coronary syndrome (ACS) and stable ischemic heart disease (IHD). METHODS: We recruited 997 young patients (men <55, women <65y) presenting with ACS or stable IHD successively at 22 centers across India...
March 2017: Indian Heart Journal
https://www.readbyqxmd.com/read/28457177/high-sensitivity-cardiac-troponin-assays-from-improved-analytical-performance-to-enhanced-risk-stratification
#19
Marek Kozinski, Magdalena Krintus, Jacek Kubica, Grazyna Sypniewska
Implementation of cardiac troponin (cTn) assays has revolutionized the diagnosis, risk stratification, triage and management of patients with suspected myocardial infarction (MI). The Universal Definition of MI brought about a shift in the diagnostics of MI, from an approach primarily based on electrocardiography (ECG) to one primarily based on biomarkers. Currently, detection of a rise and/or fall in concentration or activity of myocardial necrosis biomarkers, preferentially cTns, with at least one value above the 99th percentile upper reference limit (URL), is the essential component for the diagnosis of MI...
May 2017: Critical Reviews in Clinical Laboratory Sciences
https://www.readbyqxmd.com/read/28454795/rationale-and-design-of-the-japan-usa-harmonized-assessment-by-randomized-multicenter-study-of-orbusneich-s-combo-stent-japan-usa-harmonee-assessment-of-a-novel-des-platform-for-percutaneous-coronary-revascularization-in-patients-with-ischemic-coronary-disease
#20
David F Kong, Shigeru Saito, Shigeru Nakamura, Roxana Mehran, Stephen M Rowland, Allison Handler, Hussein R Al-Khalidi, Mitchell W Krucoff
Tissue trauma associated with stent implantation continues to generate early thrombosis rates of 0.9% to 1.3% for both bare-metal and drug-eluting stent platforms. The Combo sirolimus-eluting stent combines an abluminal, bioabsorbable polymer with a luminal CD34+ antibody designed to capture endothelial progenitor cells. This article describes the design and methods of the HARMONEE trial (NCT02073565), which represents the first randomized controlled trial of the Combo design against a best-in-class contemporary everolimus-eluting stent...
May 2017: American Heart Journal
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