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arrhythmias, ST-Elevation Myocardial Infarction,

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https://www.readbyqxmd.com/read/29339700/assessment-of-the-relationship-between-reperfusion-success-and-t-peak-to-t-end-interval-in-patients-with-st-elevation-myocardial-infarction-treated-with-percutaneous-coronary-intervention
#1
Metin Çağdaş, Süleyman Karakoyun, İbrahim Rencüzoğulları, Yavuz Karabağ, Mahmut Yesin, Yalçın Velibey, İnanç Artaç, Doğan İliş, Süleyman Çağan Efe, Onur Taşar, Halil İbrahim Tanboğa
OBJECTIVE: T-peak-T-end (TPE) interval, which represents the dispersion of repolarization, is defined as the interval between the peak and end of the T-wave, and is associated with increased malignant ventricular arrhythmia and sudden cardiac death (SCD) in patients with ST elevation myocardial infarction (STEMI). Although prolonged TPE interval is associated with poor short- and long-term outcomes, even in patients with STEMI treated with successful primary percutaneous coronary intervention (pPCI), clinical, angiographic, and laboratory parameters that affect TPE remain to be elucidated...
January 2018: Anatolian Journal of Cardiology
https://www.readbyqxmd.com/read/29320987/effect-of-intracoronary-agents-on-the-no-reflow-phenomenon-during-primary-percutaneous-coronary-intervention-in-patients-with-st-elevation-myocardial-infarction-a-network-meta-analysis
#2
Xiaowei Niu, Jingjing Zhang, Ming Bai, Yu Peng, Shaobo Sun, Zheng Zhang
BACKGROUND: Despite the restoration of epicardial flow after primary percutaneous coronary intervention (PPCI), myocardial reperfusion remains impaired in a significant proportion of patients. We performed a network meta-analysis to assess the effect of 7 intracoronary agents (adenosine, anisodamine, diltiazem, nicorandil, nitroprusside, urapidil, and verapamil) on the no-reflow phenomenon in patients with ST-elevation myocardial infarction (STEMI) undergoing PPCI. METHODS: Database searches were conducted to identify randomized controlled trials (RCTs) comparing the 7 agents with each other or with standard PPCI...
January 10, 2018: BMC Cardiovascular Disorders
https://www.readbyqxmd.com/read/29275878/microcatheter-facilitated-primary-angioplasty-in-st-segment-elevation-myocardial-infarction
#3
Guy Achkouty, Jean-Guillaume Dillinger, Georgios Sideris, Stephane Manzo-Silberman, Sebastian Voicu, Benoit Merat, Damien Logeart, Patrick Henry
BACKGROUND: Direct stenting is the best method for achieving reperfusion in primary percutaneous coronary intervention (PPCI). We hypothesized that the use of a microcatheter (MC) during PPCI when Thrombolysis in Myocardial Infarction (TIMI) flow ≤ 1 after wire crossing would allow visualization of the downstream artery with an optimal TIMI 3 flow at the end of the procedure. METHODS: In this pilot study, PPCI patients with TIMI flow ≤ 1 after wire crossing formed the MC group (n = 60); the MC was positioned in the distal part of the culprit artery and a small amount of contrast was injected through it to determine stent size and length to treat the culprit lesion...
January 2018: Canadian Journal of Cardiology
https://www.readbyqxmd.com/read/29247520/lithium-induced-electrocardiographic-changes-a-complete-review
#4
REVIEW
Nikhil Mehta, Robert Vannozzi
Lithium has been used for the treatment of bipolar disorder for more than 6 decades. Reports of cardiac side effects resulting in both benign electrocardiographic (ECG) changes and near fatal arrhythmias have been reported in the literature. A systematic literature search was conducted on 2 electronic databases-PubMed and Medline-for the time period between January 1970 and March 2016 using the key word "lithium," along with "electrocardiography" or "ECG." All articles and their references were then screened by title for relevance by 2 authors and a librarian...
December 16, 2017: Clinical Cardiology
https://www.readbyqxmd.com/read/29243292/effects-of-endovascular-cooling-on-infarct-size-in-st-segment-elevation-myocardial-infarction-a-patient-level-pooled-analysis-from-randomized-trials
#5
Michael Dae, William O'Neill, Cindy Grines, Simon Dixon, David Erlinge, Marko Noc, Michael Holzer, Anne Dee
OBJECTIVES: This study sought to examine the relationship between temperature at reperfusion and infarct size. BACKGROUND: Hypothermia consistently reduces infarct size when administered prior to reperfusion in animal studies, however, clinical results have been inconsistent. METHODS: We performed a patient-level pooled analysis from six randomized control trials of endovascular cooling during primary percutaneous coronary intervention (PCI) for ST-segment elevation myocardial infarction (STEMI) in 629 patients in which infarct size was assessed within 1 month after randomization by either single-photon emission computed tomography (SPECT) or cardiac magnetic resonance imaging (cMR)...
December 14, 2017: Journal of Interventional Cardiology
https://www.readbyqxmd.com/read/29208507/myrtenol-protects-against-myocardial-ischemia-reperfusion-injury-through-antioxidant-and-anti-apoptotic-dependent-mechanisms
#6
Raquel Moreira de Britto, Júlio Alves da Silva Neto, Thássio Ricardo Ribeiro Mesquita, Carla Maria Lins de Vasconcelos, Grace Kelly Melo de Almeida, Itamar Couto Guedes de Jesus, Péligris Henrique Dos Santos, Diego Santos de Souza, Rodrigo Miguel-Dos-Santos, Lucas Andrade de Sá, Fanildes Silva Moraes Dos Santos, Rose Nely Pereira-Filho, Ricardo Luiz Cavalcanti Albuquerque-Júnior, Lucindo José Quintans-Júnior, Silvia Guatimosim, Sandra Lauton-Santos
Myrtenol is a monoterpene with multiple pharmacological activities. However, although monoterpenes have been proposed to play beneficial roles in a variety of cardiac disorders, pharmacological actions of myrtenol in the heart are not yet reported. Hence, the aim of this study was to evaluate whether myrtenol promotes cardioprotection against myocardial ischemia-reperfusion (IR) injury, and the mechanisms involved in these effects. Male Wistar rats were orally treated for seven consecutive days with myrtenol (50 mg/kg) or N-acetyl cysteine (1...
December 2, 2017: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/29173601/autologous-bone-marrow-stem-cell-therapy-in-patients-with-st-elevation-myocardial-infarction-a-systematic-review-and-meta-analysis
#7
REVIEW
Maya M Jeyaraman, Rasheda Rabbani, Leslie Copstein, Wasan Sulaiman, Farnaz Farshidfar, Hessam H Kashani, Sheikh M Z Qadar, Qingdong Guan, Becky Skidmore, Elissavet Kardami, John Ducas, Samer Mansour, Ryan Zarychanski, Ahmed M Abou-Setta
BACKGROUND: Randomized controlled trials (RCTs) on bone marrow stem cell (BMSC) therapy in ST-elevation myocardial infarction (STEMI) patients have reported conflicting results. Our main objective was to critically appraise and meta-analyze best-available evidence on efficacy and safety of intracoronary administration of autologous BMSC therapy in STEMI patients after primary percutaneous coronary intervention. METHODS: We conducted a search of MEDLINE, PubMed, EMBASE, CENTRAL, Global Health, CINAHL, and conference proceedings in February 2017...
December 2017: Canadian Journal of Cardiology
https://www.readbyqxmd.com/read/29162046/association-of-common-genetic-variants-related-to-atrial-fibrillation-and-the-risk-of-ventricular-fibrillation-in-the-setting-of-first-st-elevation-myocardial-infarction
#8
Reza Jabbari, Javad Jabbari, Charlotte Glinge, Bjarke Risgaard, Stefan Sattler, Bo Gregers Winkel, Christian Juhl Terkelsen, Hans-Henrik Tilsted, Lisette Okkels Jensen, Mikkel Hougaard, Stig Haunsø, Thomas Engstrøm, Christine M Albert, Jacob Tfelt-Hansen
BACKGROUND: Cohort studies have revealed an increased risk for ventricular fibrillation (VF) and sudden cardiac death (SCD) in patients with atrial fibrillation (AF). In this study, we hypothesized that single nucleotide polymorphisms (SNP) previously associated with AF may be associated with the risk of VF caused by first ST-segment elevation myocardial infarction (STEMI). METHODS: We investigated association of 24 AF-associated SNPs with VF in the prospectively assembled case-control study among first STEMI-patients of Danish ancestry...
November 21, 2017: BMC Medical Genetics
https://www.readbyqxmd.com/read/29148142/outcomes-of-primary-percutaneous-coronary-intervention-in-acute-myocardial-infarction-due-to-unprotected-left-main-thrombosis-the-asia-pacific-left-main-st-elevation-registry-aster
#9
Jonathan Yap, Gagan D Singh, Jung-Sun Kim, Krishan Soni, Kelvin Chua, Alvin Neo, Choong Hou Koh, Ehrin J Armstrong, Stephen W Waldo, Kendrick A Shunk, Reginald I Low, Myeong-Ki Hong, Yangsoo Jang, Khung Keong Yeo
INTRODUCTION: Prior studies of ULM STEMI have been confined to small cohorts. Recent registry data with larger patient cohorts have shown contrasting results. We aim to study the outcomes of patients with unprotected left main (ULM) ST-elevation myocardial infarction (STEMI) who underwent primary percutaneous coronary intervention (PCI). METHODS: The Asia-pacific left main ST-Elevation Registry (ASTER) is a multicenter retrospective registry involving 4 sites in Singapore, South Korea, and the United States...
November 16, 2017: Journal of Interventional Cardiology
https://www.readbyqxmd.com/read/29138662/st-segment-elevation-after-blunt-chest-trauma-myocardial-contusion-with-normal-coronary-arteries-or-myocardial-infarction-following-coronary-lesions
#10
Amine Ghalem, Hanane Boussir, Kamal Ahsayan, Nabila Ismaili, Noha El Ouafi
Cardiac lesions secondary to blunt chest trauma vary from insignificant arrhythmias to fatal cardiac rupture. Of these, a distinction remains difficult; face to ST-segment elevation on ECG with positive cardiac biomarkers, is it a myocardial contusion or a genuine myocardial infarction (MI) secondary to coronary lesions? We report the case of a patient admitted for multiple trauma. Initial assessment showed an ST segment elevation on ECG, along with multiple fractures and abdominal injuries. We would like to discuss, through this case, the similarities and the differences between myocardial infarction due to coronary lesions and myocardial contusion in a traumatic context, but also emphasize the difficulty of striking the right balance between thrombotic and bleeding risks in this situation, and insist on the importance of a multidisciplinary and collegial reflexion so we can offer these patients the best care there is...
2017: Pan African Medical Journal
https://www.readbyqxmd.com/read/29121758/tpeak-tend-dispersion-as-a-predictor-for-malignant-arrhythmia-events-in-patients-with-vasospastic-angina
#11
Wang Xianpei, Wu Sha, Gao Chuanyu, Yan Juanjuan, Chen Chong, Shi Yongen, Feng Yu, Lin Zhenhao
BACKGROUND: Tpeak-Tend interval (Tp-e interval) in electrocardiogram (ECG) has been reported to predict malignant arrhythmia events (MAE) in ST-segment elevation myocardial infarction and ion channelopathy. Tp-e interval and other ECG parameters as predictors for MAE was evaluated in patients with vasospastic angina (VA). METHODS AND RESULTS: Sixty-two patients with VA (Non-MAE group) and 20 patients with VA complicated by MAE (MAE group) were enrolled in our Division of Cardiology between January 2010 and December 2015...
December 15, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/29118947/in-hospital-and-long-term-results-of-primary-angioplasty-and-medical-therapy-in-nonagenarian-patients-with-acute-myocardial-infarction
#12
Muslum Sahin, Lutfi Ocal, Ali Kemal Kalkan, Alev Kilicgedik, Mehmet Emin Kalkan, Burak Teymen, Ugur Arslantas, Mehmet Muhsin Turkmen
Introduction: Although percutaneous coronary intervention is an accepted "first-line" therapy in acute ST elevation myocardial infarction (STEMI) in general population, few data are available on the short- and long-term outcomes of very old patients (age >90 years). Our aim is to evaluate and compare the short and long-term outcomes after primary percutaneous coronary intervention (PPCI) or medical therapy in nonagenarian patients with STEMI. Methods: We retrospectively identified patients older than 90 years old in our clinic, with acute STEMI who presented within 12 hours after symptoms onset, either underwent PPCI or medically treated...
2017: Journal of Cardiovascular and Thoracic Research
https://www.readbyqxmd.com/read/29113999/index-of-microcirculatory-resistance-at-the-time-of-primary-percutaneous-coronary-intervention-predicts-early-cardiac-complications-insights-from-the-oxami-oxford-study-in-acute-myocardial-infarction-cohort
#13
Gregor Fahrni, Mathias Wolfrum, Giovanni Luigi De Maria, Florim Cuculi, Sam Dawkins, Mohammad Alkhalil, Niket Patel, John C Forfar, Bernard D Prendergast, Robin P Choudhury, Keith M Channon, Adrian P Banning, Rajesh K Kharbanda
BACKGROUND: Early risk stratification after primary percutaneous coronary intervention (PPCI) for ST-segment-elevation myocardial infarction is currently challenging. Identification of a low-risk group may improve triage of patients to alternative clinical pathways and support early hospital discharge. Our aim was to assess whether the index of microcirculatory resistance (IMR) at the time of PPCI can identify patients at low risk of early major cardiac complications and to compare its performance against guideline-recommended risk scores...
November 7, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29075204/human-cardiomyocyte-progenitor-cells-in-co-culture-with-rat-cardiomyocytes-form-a-pro-arrhythmic-substrate-evidence-for-two-different-arrhythmogenic-mechanisms
#14
Nicoline W Smit, Lucia Cócera Ortega, Anna M D Végh, Veronique M F Meijborg, Anke M Smits, Mischa Klerk, Anke J M Tijsen, Hanno L Tan, Marie-José H T Goumans, Gerard J J Boink, Ruben Coronel
Background: Cardiomyocyte progenitor cells (CMPCs) are a promising cell source for regenerative cell therapy to improve cardiac function after myocardial infarction. However, it is unknown whether undifferentiated CMPCs have arrhythmogenic risks. We investigate whether undifferentiated, regionally applied, human fetal CMPCs form a pro-arrhythmic substrate in co-culture with neonatal rat ventricular myocytes (NRVMs). Method: Unipolar extracellular electrograms, derived from micro-electrode arrays (8 × 8 electrodes) containing monolayers of NRVMs (control), or co-cultures of NRVMs and locally seeded CMPCs were used to determine conduction velocity and the incidence of tachy-arrhythmias...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/29067927/observational-study-comparing-pharmacoinvasive-strategy-with-primary-percutaneous-coronary-intervention-in-patients-presenting-with-st-elevation-myocardial-infarction-to-a-tertiary-care-centre-in-india
#15
A G Alex, A Lahiri, T Geevar, O K George
OBJECTIVE: The objective was to study whether the incidence of composite end points (mortality, cardiogenic shock and re-myocardial infarction [re-MI]) in pharmacoinvasive strategy was noninferior to primary percutaneous coronary intervention (PCI) in patients with ST-elevation myocardial infarction (STEMI). METHODS: This was an observational study which included 138 patients. The study included patients admitted with a diagnosis of STEMI within 24 h of symptom onset, who underwent primary PCI or pharmacoinvasive therapy in a single center over a 9-month period...
October 23, 2017: Journal of Postgraduate Medicine
https://www.readbyqxmd.com/read/29056239/short-term-exposure-to-air-pollutants-increases-the-risk-of-st-elevation-myocardial-infarction-and-of-infarct-related-ventricular-arrhythmias-and-mortality
#16
Jordi Bañeras, Ignacio Ferreira-González, Josep Ramon Marsal, José A Barrabés, Aida Ribera, Rosa Maria Lidón, Enric Domingo, Gerard Martí, David García-Dorado
BACKGROUND: The relation between STEMI and air pollution (AP) is scant. We aimed to investigate the short term association between AP and the incidence of STEMI, and STEMI-related ventricular arrhythmias (VA) and mortality. METHODS: The study was carried out in the area of Barcelona from January 2010 to December 2011. Daily STEMI rates and incidence of STEMI-related VA and mortality were obtained prospectively. The corresponding daily levels of the main pollutants were recorded as well as the atmospheric variables...
October 5, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/29026412/the-role-of-manual-thrombectomy-in-cardiovascular-outcome-among-patients-with-total-cutoff-vessel-myocardial-infarction-undergoing-primary-percutaneous-coronary-intervention
#17
Alireza Khosravi, Davoud Rajabi, Masoud Pourmoghaddas, Afzal Roohi, Masoumeh Esmaeili
BACKGROUND: The applicability of manual aspiration thrombectomy in patients with ST-segment elevation myocardial infarction (STEMI) has been a challenging issue. This study aimed to compare the impact of additive manual thrombectomy on patients with myocardial infarction (MI) and total cutoff vessel with standard primary percutaneous coronary intervention (PPCI) with bailout thrombectomy. METHODS: In this case-control study, 181 patients with acute STEMI were enrolled who referred to Chamran Hospital (Isfahan, Iran) between August to December 2014...
March 2017: ARYA Atherosclerosis
https://www.readbyqxmd.com/read/28988521/the-cardioprotective-effect-of-rosmarinic-acid-on-acute-myocardial-infarction-and-genes-involved-in-ca-2-homeostasis
#18
Somayeh Javidanpour, Mahin Dianat, Mohammad Badavi, Seyyed Ali Mard
Acute myocardial infarction (AMI) is a common cause of hospitalisation and high mortality due to lethal arrhythmias. Sarcoplasmic reticulum Ca(2+) ATPase (SERCA2) and ryanodine receptor (RyR2) regulate the cytosolic Ca(2+) ion concentration. Rosmarinic acid (RA) is one of the most common caffeic esters in Rosmarinus officinalis. The present study was conducted to test the hypothesis whether RA can protect cardiac function against AMI and arrhythmias induced by isoproterenol through the regulatory effect of SERCA2 and RyR2 gene expression...
November 3, 2017: Free Radical Research
https://www.readbyqxmd.com/read/28939546/using-smart-technology-to-improve-outcomes-in-myocardial-infarction-patients-rationale-and-design-of-a-protocol-for-a-randomized-controlled-trial-the-box
#19
Roderick Willem Treskes, Louise Anna van Winden, Nicole van Keulen, Douwe Ekke Atsma, Enno Tjeerd van der Velde, Elske van den Akker-van Marle, Bart Mertens, Martin Jan Schalij
BACKGROUND: Recent evidence suggests that frequent monitoring using smartphone-compatible wearable technologies might improve clinical effectiveness and patient satisfaction of care. OBJECTIVE: The aim of this study is to investigate the clinical effectiveness and patient satisfaction of a smart technology intervention in patients admitted with a ST elevation myocardial infarction (STEMI) or non-ST acute coronary syndrome (NST-ACS). METHODS: In this single center, open, randomized controlled trial patients who suffered from STEMI or NST-ACS will be randomized 1:1 to an intervention group or control group...
September 22, 2017: JMIR Research Protocols
https://www.readbyqxmd.com/read/28919071/validation-of-the-retrieve-reverse-triage-events-criteria-for-same-day-return-of-non-st-elevation-acute-coronary-syndrome-patients-to-referring-non-pci-centres
#20
Sonya N Burgess, Vu Huynh Nguyen, James Xu, Yoshio Hinde, Anoop Dharmadmajan, Xavier Brennan, Karen Owen, Karen Lintern, Craig Juergens, Sidney Lo, Phong Nguyen, Krishna K Kadappu, John K French, Rohan Rajaratnam
BACKGROUND: There are continuing bed constraints in percutaneous coronary intervention centres (PCI) so efficient patient triage from referral hospitals is pivotal. To evaluate a strategy of PCI centre (PCIC) bed-sparing we examined return of patients to referral hospitals screened by the RETRIEVE (REverse TRIage EVEnts) criteria and validated its use as a tool for screening suitability for same day transfer of non-ST-elevation acute coronary syndrome (NSTEACS) patients post PCI to their referring non-PCI centre (NPCIC)...
August 19, 2017: Heart, Lung & Circulation
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