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https://www.readbyqxmd.com/read/29351002/protective-effect-of-the-standardized-leaf-extract-of-ginkgo-biloba-egb761-against-hypertension-induced-renal-injury-in-rats
#1
Ahmed O Abdel-Zaher, Hanan S M Farghaly, Abeer E M El-Refaiy, Ahmed M Abd-Eldayem
BACKGROUND: Ginkgo biloba leaves extract has been widely used worldwide to protect against oxidative stress-induced cell damage and improves blood circulation. METHODS: The potential protective role of the standardized leaf extract of Ginkgo biloba (EGb761) on hypertension-induced renal injury was investigated in rats. Hypertension was induced in rats by L-NAME. RESULT: Repeated treatment with EGb761 produced progressive reductions in the systolic, diastolic and mean arterial blood pressure...
January 19, 2018: Clinical and Experimental Hypertension: CHE
https://www.readbyqxmd.com/read/29346736/light-activatable-red-blood-cell-membrane-camouflaged-dimeric-prodrug-nanoparticles-for-synergistic-photodynamic-chemotherapy
#2
Qing Pei, Xiuli Hu, Xiaohua Zheng, Shi Liu, Yawei Li, Xiabin Jing, Zhigang Xie
Biomimetic approach offers numerous opportunities to design therapeutic platforms with enhanced antitumor performance and biocompatibility. Herein we report a novel red blood cell membrane-camouflaged nanoparticle (RBC(M(TPC-PTX))) for synergistic chemo- and photodynamic therapy (PDT). Specifically, the inner core is mainly constructed by reactive oxygen species (ROS)-responsive PTX dimer (PTX2-TK) and photosensitizer 5,10,15,20-tetraphenylchlorin (TPC). In vitro experiments show that the prepared RBC(M(TPC-PTX)) is readily taken up into endosomes...
January 18, 2018: ACS Nano
https://www.readbyqxmd.com/read/29344346/characterization-and-selective-incorporation-of-small-non-coding-rnas-in-non-small-cell-lung-cancer-extracellular-vesicles
#3
Chuang Li, Fang Qin, Fen Hu, Hui Xu, Guihong Sun, Guang Han, Tao Wang, Mingxiong Guo
Background: Extracellular vesicles (EVs) play important roles in intercellular communication through the delivery of their cargoes, which include proteins, lipids, and RNAs. Increasingly, multiple studies have reported the association between EV small non-coding RNAs and cancer, due to their regulatory functions in gene expression. Hence, analysis of the features of small non-coding RNA expression and their incorporation into EVs is important for cancer research. Results: We performed deep sequencing to investigate the expression of small RNAs in plasma EVs from lung adenocarcinoma (ADC) patients, lung squamous cell carcinoma (SQCC) patients, and healthy controls...
2018: Cell & Bioscience
https://www.readbyqxmd.com/read/29344302/evans-blue-attachment-enhances-somatostatin-receptor-subtype-2-imaging-and-radiotherapy
#4
Rui Tian, Orit Jacobson, Gang Niu, Dale O Kiesewetter, Zhantong Wang, Guizhi Zhu, Ying Ma, Gang Liu, Xiaoyuan Chen
Purpose: Radionuclide therapy directed against tumors that express somatostatin receptors (SSTRs) has proven effective for the treatment of advanced, low- to intermediate-grade neuroendocrine tumors in the clinic. In clinical usage, somatostatin peptide-based analogs, labeled with therapeutic radionuclides, provide an overall response rate of about 30%, despite the high cumulative activity injected per patient. We set out to improve the effectiveness of somatostatin radiotherapy by preparing a chemical analog that would clear more slowly through the urinary tract and, concomitantly, have increased blood circulation half-life and higher targeted accumulation in the tumors...
2018: Theranostics
https://www.readbyqxmd.com/read/29344291/in-vivo-double-targeting-of-c26-colon-carcinoma-cells-and-microenvironmental-protumor-processes-using-liposomal-simvastatin
#5
Lavinia Luput, Emilia Licarete, Denise Minerva Drotar, Andras-Laszlo Nagy, Alina Sesarman, Laura Patras, Valentin Florian Rauca, Alina Porfire, Dana Muntean, Marcela Achim, Ioan Tomuta, Laurian Vlase, Cornel Catoi, Nicolae Dragos, Manuela Banciu
Purpose: Besides cholesterol lowering effects, simvastatin (SIM) at very high doses possesses antitumor actions. Moreover our previous studies demonstrated that tumor-targeted delivery of SIM by using long-circulating liposomes (LCL) improved the therapeutic index of this drug in murine melanoma-bearing mice. To evaluate whether this finding can be exploited for future therapy of colorectal cancer the antitumor activity and the underlying mechanisms of long-circulating liposomal simvastatin (LCL-SIM) efficacy for inhibition of C26 murine colon carcinoma growth in vivo were investigated...
2018: Journal of Cancer
https://www.readbyqxmd.com/read/29344255/plasma-olfactomedin-4-level-in-peripheral-blood-and-its-association-with-clinical-features-of-breast-cancer
#6
Chaoqian Liu, Yan Guo, Weiwei Wu, Zhenzhen Zhang, Lu Xu, Kainan Wu, Wei Hu, Guoping Liu, Junyi Shi, Cheng Xu, Jianwei Bi, Yuan Sheng
The present study aimed to investigate the expression of olfactomedin 4 (OLFM4) in plasma of patients with breast cancer and its association with diagnosis, metastasis and prognosis of breast cancer. OLFM4 gene expression level of peripheral blood plasma in 60 patients with breast cancer and 26 healthy donors was examined by ELISA. The expression of OLFM4 in tumor tissues of patients with breast cancer was evaluated by immunohistochemistry (protein expression) and reverse transcription-quantitative polymerase chain reaction (mRNA expression), respectively...
December 2017: Oncology Letters
https://www.readbyqxmd.com/read/29343260/liquid-biomarkers-in-melanoma-detection-and-discovery
#7
REVIEW
Su Yin Lim, Jenny H Lee, Russell J Diefenbach, Richard F Kefford, Helen Rizos
A vast array of tumor-derived genetic, proteomic and cellular components are constantly released into the circulation of cancer patients. These molecules including circulating tumor DNA and RNA, proteins, tumor and immune cells are emerging as convenient and accurate liquid biomarkers of cancer. Circulating cancer biomarkers provide invaluable information on cancer detection and diagnosis, prognosticate patient outcomes, and predict treatment response. In this era of effective molecular targeted treatments and immunotherapies, there is now an urgent need to implement use of these circulating biomarkers in the clinic to facilitate personalized therapy...
January 17, 2018: Molecular Cancer
https://www.readbyqxmd.com/read/29341617/enhancing-docetaxel-delivery-to-multidrug-resistant-cancer-cells-with-albumin-coated-nanocrystals
#8
Sheryhan F Gad, Joonyoung Park, Ji Eun Park, Gihan N Fetih, Sozan S Tous, Wooin Lee, Yoon Yeo
Intravenous delivery of poorly water-soluble anticancer drugs such as docetaxel (DTX) is challenging due to the low bioavailability and the toxicity related to solubilizing excipients. Colloidal nanoparticles are used as alternative carriers, but low drug loading capacity and circulation instability limit their clinical translation. To address these challenges, DTX nanocrystals (NCs) were prepared using Pluronic F127 as an intermediate stabilizer and albumin as a functional surface modifier, which were previously found to be effective in producing small and stable NCs...
January 17, 2018: Molecular Pharmaceutics
https://www.readbyqxmd.com/read/29340117/the-regulation-of-pre-metastatic-niche-formation-by-neutrophils
#9
REVIEW
Jadwiga Jablonska, Stephan Lang, Ronit Vogt Sionov, Zvi Granot
Metastasis is a multistep process requiring tumor cell detachment from the primary tumor and migration to target organs through the lymphatic or blood circulatory systems. Specific organs are predisposed to metastases in certain cancers and the formation of supportive metastatic microenvironment determines tumor cell homing. Such an environment is provided by a pre-metastatic niche that is formed through the recruitment of bone marrow-derived myeloid cells, however the mechanisms of its formation are not fully understood...
December 19, 2017: Oncotarget
https://www.readbyqxmd.com/read/29339542/ampk-akt-double-negative-feedback-loop-in-breast-cancer-cells-regulates-their-adaptation-to-matrix-deprivation
#10
Manipa Saha, Saurav Kumar, Shoiab Bukhari, Sai A Balaji, Prashant Kumar, Sravanth K Hindupur, Annapoorni Rangarajan
Cell detachment from the extracellular matrix triggers anoikis. Disseminated tumor cells must adapt to survive matrix deprivation, while still retaining the ability to attach at secondary sites and re-initiate cell division. In this study, we illuminate mechanisms that enable reversible matrix attachment by breast cancer cells. Matrix deprival triggered AMPK activity and concomitantly inhibited AKT activity by upregulating the AKT phosphatase PHLPP2. The resultant pAMPKhigh/pAKTlow state was critical for cell survival in suspension, as PHLPP2 silencing also increased anoikis while impairing autophagy and metastasis...
January 16, 2018: Cancer Research
https://www.readbyqxmd.com/read/29339375/tusc2-immunogene-synergizes-with-anti-pd1-through-enhanced-proliferation-and-infiltration-of-natural-killer-cells-in-syngeneic-kras-mutant-mouse-lung-cancer-models
#11
Ismail M Meraz, Mourad Majidi, Xiaobo Cao, Heather Lin, Lerong Li, Jing Wang, Veerabhadran Baladandayuthapani, David Rice, Boris Sepesi, Lin Ji, Jack A Roth
Expression of the multikinase inhibitor encoded by tumor suppressor gene TUSC2 (also known as FUS1) is lost or decreased in non-small cell lung carcinoma (NSCLC). TUSC2 delivered systemically by nanovesicles has mediated tumor regression in clinical trials. Because of the role of TUSC2 in regulating immune cells, we assessed TUSC2 efficacy on antitumor immune responses alone and in combination with anti-PD-1 in two Kras-mutant syngeneic mouse lung cancer models. TUSC2 alone significantly reduced tumor growth and prolonged survival compared with anti-PD-1...
January 16, 2018: Cancer Immunology Research
https://www.readbyqxmd.com/read/29339080/prostate-cancer-disseminated-tumor-cells-are-rarely-detected-in-the-bone-marrow-of-localized-patients-undergoing-radical-prostatectomy-across-multiple-rare-cell-detection-platforms
#12
Heather J Chalfin, Stephanie A Glavaris, Paymaneh D Malihi, Jamie M Sperger, Michael A Gorin, Changxue Lu, C Rory Goodwin, Yan Chen, Emily A Caruso, Ruth Dumpit, Peter Kuhn, Joshua M Lang, Peter S Nelson, Jun Luo, Kenneth J Pienta
PURPOSE: Prostate circulating tumor cells escape into the peripheral blood and enter the bone marrow as disseminated tumor cells, representing an early step before conventionally detectable metastasis. It is unclear how frequently this occurs in localized disease, and existing detection methods rely on epithelial markers with low specificity and sensitivity. Here we employed multiple methodologies of disseminated tumor cell detection in bone marrow harvested at radical prostatectomy. MATERIALS AND METHODS: Bone marrow was harvested from 208 clinically localized patients, 16 controls, and 5 metastatic patients, with peripheral blood from 37 metastatic patients...
January 12, 2018: Journal of Urology
https://www.readbyqxmd.com/read/29338768/binary-blend-fibber-based-capture-assay-of-circulating-tumor-cells-for-clinical-diagnosis-of-colorectal-cancer
#13
Ai-Wei Lee, Fu-Xiang Lin, Po-Li Wei, Guo Jian-Wei, Jem-Kun Chen
BACKGROUND: In addition to conventional approaches, detecting and characterizing CTCs in patient blood allows for early diagnosis of cancer metastasis. METHODS: We blended poly(ethylene oxide) (PEO) into nylon-6 through electrospinning to generate a fibrous matbased circulating tumour cells (CTCs) assay. The contents of nylon-6 and PEO in the electrospun blend fibrous mats (EBFMs) were optimized to facilitate high cell-substrate affinity and low leukocyte adsorption...
January 16, 2018: Journal of Nanobiotechnology
https://www.readbyqxmd.com/read/29338190/cancer-cell-membrane-biomimetic-nanoprobes-with-two-photon-excitation-and-near-infrared-emission-for-intravital-tumor-fluorescence-imaging
#14
Yanlin Lv, Ming Liu, Yong Zhang, Xuefei Wang, Fan Zhang, Feng Li, Weier Bao, Jie Wang, Yuanlin Zhang, Wei Wei, Guanghui Ma, Liancheng Zhao, Zhiyuan Tian
Biomimetic fluorescent nanoprobes capable of emitting near-infrared (NIR) fluorescence (λmax ~720 nm) upon excitation of 800-nm light were developed. The key conjugated polymer enabled two-photon absorption (TPA) and Fӧrster resonance energy transfer (FRET) processes within the nanoprobes, which imparted the nanoprobes with ideal NIR-incoming-NIR-outgoing fluorescence features. The cancer cell membrane (CM) coating endowed these nanoprobes with perfect biocompatibility and highly specific targeting ability to homologous tumors...
January 16, 2018: ACS Nano
https://www.readbyqxmd.com/read/29338184/design-of-ph-sensitive-nanovesicles-via-cholesterol-analogue-incorporation-for-improving-in-vivo-delivery-of-chemotherapeutics
#15
Lina Liang, Jun Fu, Liyan Qiu
pH-responsive polymersomes have emerged as promising nanocarriers for antitumor drugs to realize their fast release and action in weak acidic microenvironment of tumor cells. Herein, however, we designed a remarkably pH-responsive polymersome self-assembled from amphiphilic benzimidazole-based polyphosphazenes via the incorporation of cholesteryl hemisuccinate (CholHS), a type of cholesteric molecule, into the polymersome bilayers to inhibit the drug release during blood circulation. Actually, unwanted premature drug leakage before arriving at acidic tumor site has become a serious problem for polymersomes encapsulating water-soluble drugs, especially when the drug-loading is at a high level, thus limiting the therapeutic efficacy...
January 17, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29337932/high-number-of-circulating-tumor-cells-predicts-poor-survival-of-cutaneous-melanoma-patients-in-china
#16
Jisen Li, Wenhua Fu, Wei Zhang, Peng Li
BACKGROUND Melanoma is an aggressive cancer with complex etiology and poor prognosis. Surgical resection is still the primary treatment of melanoma, but shows limited efficacy in late-stage patients. Additionally, reliable prognostic markers of skin melanoma patients are still lacking. Circulating tumor cells (CTCs) have shown promise in predicting prognosis of multiple cancers. Evaluating the prognostic value of CTC number in melanoma patients. MATERIAL AND METHODS CTCs were isolated by immunomagnetic capture from 7...
January 16, 2018: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/29337566/cationic-polymeric-nanoparticle-delivering-ccr2-sirna-to-inflammatory-monocytes-for-tumor-microenvironment-modification-and-cancer-therapy
#17
Song Shen, Yue Zhang, Kai-Ge Chen, Ying-Li Luo, Jun Wang
Accumulating evidence has confirmed that malignant tumors have a complex microenvironment, which consists of a heterogeneous collection of tumor cells and other cell subsets (including the full gamut of immune cells). Tumor-associated macrophages (TAMs), derived from circulating Ly6Chi monocytes, constitute the most substantial fraction of tumor-infiltrating immune cells in nearly all cancer types and contribute to tumor progression, vascularization, metastasis, immunosuppression and therapeutic resistance...
January 16, 2018: Molecular Pharmaceutics
https://www.readbyqxmd.com/read/29337110/muc16-c-terminal-induced-secretion-of-tumor-derived-il-6-contributes-to-tumor-associated-treg-enrichment-in-pancreatic-cancer
#18
Kun Fan, Chao Yang, Zhiyao Fan, Qiuyi Huang, Yiyin Zhang, He Cheng, Kaizhou Jin, Yu Lu, Zhengshi Wang, Guopei Luo, Xianjun Yu, Chen Liu
Pancreatic cancer is the most lethal tumor. CA125 (gene symbol MUC16) is an important serum marker for pancreatic cancer diagnosis and treatment. High serum CA125 is related to metabolic tumor burden and poor prognosis. The circulating Treg subset is another independent prognostic factor for pancreatic cancer. Our unpublished data indicated that the circulating Treg proportion might be related to the serum CA125 level. However, the potential relationship and underlying mechanism of MUC16 and Treg in pancreatic cancer tissues remain unclear...
January 11, 2018: Cancer Letters
https://www.readbyqxmd.com/read/29336888/lxr-apoe-activation-restricts-innate-immune-suppression-in-cancer
#19
Masoud F Tavazoie, Ilana Pollack, Raissa Tanqueco, Benjamin N Ostendorf, Bernardo S Reis, Foster C Gonsalves, Isabel Kurth, Celia Andreu-Agullo, Mark L Derbyshire, Jessica Posada, Shugaku Takeda, Kimia N Tafreshian, Eric Rowinsky, Michael Szarek, Roger J Waltzman, Elizabeth A Mcmillan, Connie Zhao, Monica Mita, Alain Mita, Bartosz Chmielowski, Michael A Postow, Antoni Ribas, Daniel Mucida, Sohail F Tavazoie
Therapeutic harnessing of adaptive immunity via checkpoint inhibition has transformed the treatment of many cancers. Despite unprecedented long-term responses, most patients do not respond to these therapies. Immunotherapy non-responders often harbor high levels of circulating myeloid-derived suppressor cells (MDSCs)-an immunosuppressive innate cell population. Through genetic and pharmacological approaches, we uncovered a pathway governing MDSC abundance in multiple cancer types. Therapeutic liver-X nuclear receptor (LXR) agonism reduced MDSC abundance in murine models and in patients treated in a first-in-human dose escalation phase 1 trial...
January 9, 2018: Cell
https://www.readbyqxmd.com/read/29335887/sphingadienes-show-therapeutic-efficacy-in-neuroblastoma-in-vitro-and-in-vivo-by-targeting-the-akt-signaling-pathway
#20
Piming Zhao, Ana E Aguilar, Joanna Y Lee, Lucy A Paul, Jung H Suh, Latika Puri, Meng Zhang, Jennifer Beckstead, Andrzej Witkowski, Robert O Ryan, Julie D Saba
Neuroblastoma is a childhood malignancy that accounts for approximately 15% of childhood cancer deaths. Only 20-35% of children with metastatic neuroblastoma survive with standard therapy. Identification of more effective therapies is essential to improving the outcome of children with high-stage disease. Sphingadienes (SD) are growth-inhibitory sphingolipids found in natural sources including soy. They exhibit chemopreventive activity in mouse models of colon cancer, where they mediate cytotoxicity by inhibiting key pro-carcinogenic signaling pathways...
January 16, 2018: Investigational New Drugs
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