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https://www.readbyqxmd.com/read/28382128/endolymphatic-sac-surgery-for-m%C3%A3-ni%C3%A3-re-s-disease-current-opinion-and-literature-review
#1
Maria de Lourdes Flores García, Carolina de la Llata Segura, Juan Carlos Cisneros Lesser, Carlo Pane Pianese
Introduction The endolymphatic sac is thought to maintain the hydrostatic pressure and endolymph homeostasis for the inner ear, and its dysfunction may contribute to the pathophysiology of Ménière's disease. Throughout the years, different surgical procedures for intractable vertigo secondary to Ménière's disease have been described, and though many authors consider these procedures as effective, there are some who question its long-term efficacy and even those who think that vertigo control is achieved more due to a placebo effect than because of the procedure itself...
April 2017: International Archives of Otorhinolaryngology
https://www.readbyqxmd.com/read/28353567/are-normal-hips-being-labeled-as-femoroacetabular-impingement-due-to-ee-angle
#2
Tian You, Bei Yang, Xin-Tao Zhang, Xiao-Cheng Jiang, Shuang Wang, Wen-Tao Zhang
Gluteal muscle contracture (GMC) is a clinical syndrome characterized by gait abnormality and limb dysfunction, as well as secondary deformities of pelvis and femur. Femoroacetabular impingement (FAI) typically could be diagnosed on the basis of computed tomography (CT) such as the equatorial-edge angle (EE angle), but it did not work well in GMC patients. In this study, we retrospected all image data and found small EE angles in GMCs, which meant retroverted acetabulum; however, none of them showed no symptoms and signs of FAI...
March 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28341275/current-thinking-about-the-management-of-dysfunction-of-the-temporomandibular-joint-a-review
#3
REVIEW
S Rajapakse, N Ahmed, A J Sidebottom
Increasingly the management of TMJ pathology is becoming a subspecialist interest. The number of patients having TMJ joint replacement had steadily increased over the last decade and there is now NICE guidance on this matter. Whilst the evidence of the management of TMJ disease is limited and there are few randomised controlled trials, the incidence of TMJ pathology has not changed and there is a requirement for guidance on the management. Whilst previously patients with TMJ pain were managed surgically, this is changing, and the vast bulk of initial management is non-surgical/medical...
March 21, 2017: British Journal of Oral & Maxillofacial Surgery
https://www.readbyqxmd.com/read/28335700/cochlear-implants-in-the-management-of-hearing-loss-in-neurofibromatosis-type-2
#4
Frances Harris, James R Tysome, Neil Donnelly, Juliette Durie-Gair, Gemma Crundwell, Yu Chuen Tam, Richard D Knight, Zebunnisa H Vanat, Nicola Folland, Patrick Axon
OBJECTIVE: Review of cochlear implant (CI) outcomes in patients with Neurofibromatosis Type 2 (NF2), implanted in the presence of an ipsilateral vestibular schwannoma (VS). Hearing restoration was combined in some cases with a Bevacizumab regime. METHOD: Retrospective review of 12 patients, managed over the period 2009-2016, at a tertiary referral multidisciplinary NF2 clinic. The patients are grouped by hearing outcomes to explore likely protective factors, and to generate a proposed decision-making tool for the selection of either CI or Auditory Brainstem Implant (ABI)...
May 2017: Cochlear Implants International
https://www.readbyqxmd.com/read/28321291/re-thinking-barriers-to-organizational-change-in-public-hospitals
#5
Nigel Edwards, Richard B Saltman
Public hospitals are well known to be difficult to reform. This paper provides a comprehensive six-part analytic framework that can help policymakers and managers better shape their organizational and institutional behavior. The paper first describes three separate structural characteristics which, together, inhibit effective problem description and policy design for public hospitals. These three structural constraints are i) the dysfunctional characteristics found in most organizations, ii) the particular dysfunctions of professional health sector organizations, and iii) the additional dysfunctional dimensions of politically managed organizations...
2017: Israel Journal of Health Policy Research
https://www.readbyqxmd.com/read/28241130/nardostachys-jatamansi-targets-bdnf-trkb-to-alleviate-ketamine-induced-schizophrenia-like-symptoms-in-rats
#6
Anjali Janardhanan, Anjana Sadanand, Arambakkam Janardhanam Vanisree
OBJECTIVE: Schizophrenia, a common neurological disorder appearing in the late teens or early adulthood, is characterized by disorganized thinking, behaviour, and perception of emotions. Aberrant N-methyl-D-aspartate (NMDA) receptor-mediated synaptic plasticity is a major pathological event here due to dysfunction of dopamine and glutamate transmission at NMDA receptors. De-regulated brain-derived neurotrophic factor (BDNF), i.e., its signalling through the tropomyosin receptor kinase B (TrkB) receptor, is a major feature of schizophrenia...
2016: Neuropsychobiology
https://www.readbyqxmd.com/read/28217067/septo-optic-dysplasia-de-morsier-s-syndrome
#7
Pedro Reis, Joana Mourão
Septo-optic dysplasia (SOD)/de Morsier's syndrome is characterized by optic nerve hypoplasia, pituitary endocrine dysfunction, and midline brain abnormalities. Hypopituitarism, hypothyroidism, hypogonadism, and adrenal insufficiency can lead to severe hypoglycemia, adrenal crisis, seizures, and sudden death. Anesthetic management of SOD was associated with high perioperative mortality. A 9-year-old male child proposed for dental treatments/extractions. Medical history of SOD with hypopituitarism, hypothyroidism, and delayed psychomotor development was observed...
January 2017: Saudi Journal of Anaesthesia
https://www.readbyqxmd.com/read/28208966/study-of-parental-perceptions-on-health-social-needs-of-children-with-neuro-developmental-disability-and-it-s-impact-on-the-family
#8
Nusrat Jahan Rafique Ansari, Ramchandra Keshav Dhongade, Preeti Sagar Lad, Ashwin Borade, Suvarna Yg, Vishal Yadav, Ashwini Mehetre, Rahul Kulkarni
INTRODUCTION: The term Neuro Developmental Disorder (NDD) is used for conditions caused by a dysfunction in any part of the brain or nervous system, resulting in physical and/or psychological symptoms as a child develops. Family of children with NDD face many problems. It is very important to find them and create awareness so that gaps in essential services and supports can be decreased. AIM: To explore parental perceptions on health & social needs of children with NDD, to understand the impact of disability on the families having children with disability, and to find out the parental perceptions on availability of services for children with NDD and its utilization by families...
December 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28208098/-don-t-think-i-m-going-to-leave-you-over-it-accounts-of-changing-hepatitis-c-status-among-couples-who-inject-drugs
#9
Jake Rance, Carla Treloar, Suzanne Fraser, Joanne Bryant, Tim Rhodes
BACKGROUND: While the health-related benefits of intimate partnership are well documented, little attention has been paid to couples exposed to high levels of social stigma and exclusion. In this project we investigated an important site of stigma for partnerships by collecting accounts of changing hepatitis C (HCV) status ("sero-change") among couples that inject drugs. We explored what these accounts reveal about the meaning of HCV for these couples, and how this understanding contributes to our collective efforts at prevention and care...
April 1, 2017: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/28195350/overcoming-the-divide-between-ataxias-and-spastic-paraplegias-shared-phenotypes-genes-and-pathways
#10
REVIEW
Matthis Synofzik, Rebecca Schüle
Autosomal-dominant spinocerebellar ataxias, autosomal-recessive spinocerebellar ataxias, and hereditary spastic paraplegias have traditionally been designated in separate clinicogenetic disease classifications. This classification system still largely frames clinical thinking and genetic workup in clinical practice. Yet, with the advent of next-generation sequencing, phenotypically unbiased studies have revealed the limitations of this classification system. Various genes (eg, SPG7, SYNE1, PNPLA6) traditionally rooted in either the ataxia or hereditary spastic paraplegia classification system have now been shown to cause ataxia on the one end of the disease continuum and hereditary spastic paraplegia on the other...
February 14, 2017: Movement Disorders: Official Journal of the Movement Disorder Society
https://www.readbyqxmd.com/read/28191365/thinking-and-feeling-individual-differences-in-habitual-emotion-regulation-and-stress-related-mood-are-associated-with-prefrontal-executive-control
#11
Matthew A Scult, Annchen R Knodt, Johnna R Swartz, Bartholomew D Brigidi, Ahmad R Hariri
Calculating math problems from memory may seem unrelated to everyday processing of emotions, but they have more in common than one might think. Prior research highlights the importance of the dorsolateral prefrontal cortex (dlPFC) in executive control, intentional emotion regulation, and experience of dysfunctional mood and anxiety. While it has been hypothesized that emotion regulation may be related to 'cold' (ie. not emotion-related) executive control, this assertion has not been tested. We address this gap by providing evidence that greater dlPFC activity during 'cold' executive control is associated with increased use of cognitive reappraisal to regulate emotions in everyday life...
2017: Clinical Psychological Science
https://www.readbyqxmd.com/read/28190407/validity-evidence-of-the-spanish-version-of-the-automatic-thoughts-questionnaire-8-in-colombia
#12
Francisco J Ruiz, Juan C Suárez-Falcón, Diana Riaño-Hernández
The Automatic Thoughts Questionnaire (ATQ) is a widely used, 30-item, 5-point Likert-type scale that measures the frequency of negative automatic thoughts as experienced by individuals suffering from depression. However, there is some controversy about the factor structure of the ATQ, and its application can be too time-consuming for survey research. Accordingly, an abbreviated, 8-item version of the ATQ has been proposed. The aim of this study was to analyze the validity evidence of the Spanish version of the ATQ-8 in Colombia...
February 13, 2017: Spanish Journal of Psychology
https://www.readbyqxmd.com/read/28188757/cognitive-effects-of-androgen-deprivation-therapy-in-men-with-advanced-prostate-cancer
#13
Bulent Gunlusoy, Yasin Ceylan, Aslı Koskderlioglu, Muhtesem Gedizlioglu, Tansu Degirmenci, Pınar Ortan, Zafer Kozacioglu
OBJECTIVES: To evaluate prostate cancer effects of androgen deprivation therapy (ADT) by using a systematic set of methods to calculate specific cognitive functions in men with locally advanced or metastatic prostate cancer. METHODS: From April 2014 to February 2016, a prospective, comparative study was done to evaluate the cognitive effects of hormone therapy.Group 1 consisted of 78 patients with locally advanced or metastatic prostate cancer who received complete ADT treatment continously for 12 months and group 2 (control group) consisted of 78 patients who underwent radical prostatectomy without any additional treatment...
February 7, 2017: Urology
https://www.readbyqxmd.com/read/28174288/direct-substrate-delivery-into-mitochondrial-fission-deficient-pancreatic-islets-rescues-insulin-secretion
#14
Uma D Kabra, Katrin Pfuhlmann, Adriana Migliorini, Susanne Keipert, Daniel Lamp, Olle Korsgren, Moritz Gegg, Stephen C Woods, Paul T Pfluger, Heiko Lickert, Charles Affourtit, Matthias H Tschöp, Martin Jastroch
In pancreatic beta cells, mitochondrial bioenergetics control glucose-stimulated insulin secretion (GSIS). Mitochondrial dynamics are generally associated with quality control, maintaining the functionality of bioenergetics. By acute pharmacological inhibition of mitochondrial fission protein Drp1, we here demonstrate that mitochondrial fission is necessary for GSIS in mouse and human islets. We confirm that genetic silencing of Drp1 increases mitochondrial proton leak in MIN6 cells. However, our comprehensive analysis of pancreatic islet bioenergetics reveals that Drp1 does not control insulin secretion via its effect on proton leak but instead via modulation of glucose-fuelled respiration...
February 7, 2017: Diabetes
https://www.readbyqxmd.com/read/28135621/the-mediating-role-of-dichotomous-thinking-and-emotional-eating-in-the-relationship-between-depression-and-bmi
#15
Evangelia E Antoniou, Peggy Bongers, Anita Jansen
Obesity and depression have important health implications. Although there is knowledge about the moderators of the depression-obesity association, our understanding of the potential behavioral and cognitive mediators that may explain the relationship between depression and obesity, is scarcely researched. The aim of this study is to investigate the mediating role of emotional eating and dichotomous thinking in the depression-obesity relationship. Data on 205 individuals from a community-based study conducted at Maastricht University, Netherlands were used...
January 17, 2017: Eating Behaviors
https://www.readbyqxmd.com/read/28132098/animal-models-for-dysphagia-studies-what-have-we-learnt-so-far
#16
REVIEW
Rebecca Z German, A W Crompton, Francois D H Gould, Allan J Thexton
Research using animal models has contributed significantly to realizing the goal of understanding dysfunction and improving the care of patients who suffer from dysphagia. But why should other researchers and the clinicians who see patients day in and day out care about this work? Results from studies of animal models have the potential to change and grow how we think about dysphagia research and practice in general, well beyond applying specific results to human studies. Animal research provides two key contributions to our understanding of dysphagia...
February 2017: Dysphagia
https://www.readbyqxmd.com/read/28089694/affective-and-cognitive-correlates-of-ptsd-electrocortical-processing-of-threat-and-perseverative-errors-on-the-wcst-in-combat-related-ptsd
#17
Julia A DiGangi, Autumn Kujawa, Darrin M Aase, Joseph M Babione, Christopher Schroth, David M Levy, Amy E Kennedy, Justin E Greenstein, Eric Proescher, Robert Walters, Holly Passi, Scott A Langenecker, K Luan Phan
PTSD is characterized by both affective and cognitive dysfunction. Affectively, PTSD is associated with both heightened emotional reactivity and disengagement. Cognitively, perseverative thinking is a core feature of the disorder. In order to assess the interactive effects of affective and cognitive correlates of PTSD symptoms, 47 OEF/OIF/OND veterans completed an emotional faces matching task while EEG (i.e., late positive potential; LPP) was recorded, and separately completed the Wisconsin Card Sorting Test (WCST) to assess perseverative errors...
April 3, 2017: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://www.readbyqxmd.com/read/28081516/autism-does-not-limit-strategic-thinking-in-the-beauty-contest-game
#18
Peter C Pantelis, Daniel P Kennedy
A popular hypothesis in developmental psychology is that individuals with autism spectrum disorder (ASD) have a specific impairment or developmental delay in their ability to reason about other people's mental processes, especially when this reasoning process is of a higher-order, recursive, or nested variety. One type of interpersonal interaction that involves this sort of complex reasoning about others' minds is an economic game, and because economic games have been extensively modeled in behavioral economics, they provide a unique testbed for a quantitative and precise analysis of cognitive functioning in ASD...
March 2017: Cognition
https://www.readbyqxmd.com/read/28073189/relationship-between-lower-urinary-tract-symptoms-and-inguinal-hernia
#19
Aykut Buğra Sentürk, Musa Ekici, Ibrahim Tayfun Sahiner, Tuncay Tas, Basri Cakiroglu
AIM: To determine the relationship between inguinal hernia (and inguinal hernia subtypes) and low urinary tract symptoms (LUTS) due to benign prostate hyperplasia (BPH), that could be more common than we think. METHOD: The study was designed retrospectively and was done in accordance with the principles of the Declaration of Helsinki, including 100 patients aged > 50 years that were divided into 2 groups: patients with BPH (BPH group) and patients with BPH and inguinal hernia (BPH-IH group 2)...
December 30, 2016: Archivio Italiano di Urologia, Andrologia
https://www.readbyqxmd.com/read/28073188/effects-of-obesity-surgery-laparoscopic-sleeve-gastrectomy-technique-on-lower-urinary-tract-symptoms-depression-and-quality-of-life-of-males-prospective-study
#20
Fatih Uruç, Serkan Akan, Bekir Aras, Çaglar Yıldırım, Aytaç Sahin, Ozgur Haki Yuksel, Mehmet Timuçin Aydın, Ayhan Verit
PURPOSE: Technically, obesity weakens the pelvic base muscles by causing an increase in the intraabdominal pressure and intravesical pressure due to increasing fat and it triggers the occurrence of lower urinary tract symptoms. However it is believed that weight loss will cause recovery of these symptoms. Our purpose in this study is to research about the effects of the weight loss achieved by using especially the Laparoscopic Sleeve Gastrectomy (LSG) technique of bariatric surgery which is being more and more widely used today...
December 30, 2016: Archivio Italiano di Urologia, Andrologia
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