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https://www.readbyqxmd.com/read/28718864/-cognitive-behavioral-group-therapy-addressing-fear-of-progression-in-cancer-out-patients
#1
Bärbel Rudolph, Alexander Wünsch, Peter Herschbach, Andreas Dinkel
Fear of progression (FoP) is an appropriate, rational response to the real threat of cancer and its treatments. However, patients experiencing elevated, dysfunctional levels of FoP often feel severely distressed and are in need of treatment. We previously conducted a (partly-)randomized controlled study with cancer patients undergoing in-patient rehabilitation and showed that a brief, four-session cognitive-behavioral group therapy significantly reduced dysfunctional FoP. In this report, we describe the adaption of the cognitive-behavioral group therapy program for use with cancer out-patients...
June 29, 2017: Psychotherapie, Psychosomatik, Medizinische Psychologie
https://www.readbyqxmd.com/read/28693878/depression-and-health-related-quality-of-life-and-their-association-with-resourcefulness-in-survivors-of-prostate-cancer
#2
Hung-Yu Lin, Hui-Ling Lai, Chun-I Chen, Chiung-Yu Huang
OBJECTIVE: This study aimed to identify the determinants of depressive symptoms (DSs) and health-related quality of life (HRQOL) in survivors of prostate cancer (PC). METHODS: This study used a descriptive, correlational design to assess a sample of 133 individuals with PC. The participants were face-to-face interviewed to collect demographic data and disease characteristics, assess self-control schedule, and survey health status. Correlation analysis, Student's t-test, ANOVA, and regression analysis were applied...
August 2017: Archives of Psychiatric Nursing
https://www.readbyqxmd.com/read/28663076/family-functioning-and-parents-dispositions-moderate-the-affective-attentional-and-physiological-consequences-of-rumination-in-children
#3
Cristina Ottaviani, Antonia Lonigro, Blu Cioffi, Demetria Manzi, Fiorenzo Laghi, Roberto Baiocco
In adults, rumination has been associated with costs at affective, cognitive, and physiological levels. We examined if rumination in children is characterized by the same dysfunctional consequences and the possible moderating role of family functioning (cohesion and flexibility) and parents' trait rumination and depression. After induction of rumination, forty children (20 girls; 9.6 years) performed a tracking task with thought probes while their mood, reaction times (RT), heart rate (HR), and variability (HRV) were assessed...
June 27, 2017: Biological Psychology
https://www.readbyqxmd.com/read/28662161/absence-of-eeg-correlates-of-self-referential-processing-depth-in-als
#4
Tatiana Fomina, Sebastian Weichwald, Matthis Synofzik, Jenifer Just, Ludger Schöls, Bernhard Schölkopf, Moritz Grosse-Wentrup
Self-referential processing is a key cognitive process, associated with the serotonergic system and the default mode network (DMN). Decreased levels of serotonin and reduced activations of the DMN observed in amyotrophic lateral sclerosis (ALS) suggest that self-referential processing might be altered in patients with ALS. Here, we investigate the effects of ALS on the electroencephalography correlates of self-referential thinking. We find that electroencephalography (EEG) correlates of self-referential thinking are present in healthy individuals, but not in those with ALS...
2017: PloS One
https://www.readbyqxmd.com/read/28660605/evaluation-of-depressive-mood-and-cognitive-functions-in-patients-with-acromegaly-under-somatostatin-analogue-therapy
#5
H Alibas, K Uluc, P Kahraman Koytak, M M Uygur, N Tuncer, T Tanridag, D Gogas Yavuz
AIMS: Acromegaly is caused by a pituitary adenoma that releases excess growth hormone (GH) and a concomitant increase in insulin-like growth factor 1 (IGF-1). Acromegaly results not only in phenotypic changes, but also in neurologic complications as peripheral neuropathy and cognitive dysfunction. This study aimed to compare depressive mood and cognitive function in patients with acromegaly and in healthy controls as well as to determine the factors underlying cognitive dysfunction in the acromegalic patients...
June 28, 2017: Journal of Endocrinological Investigation
https://www.readbyqxmd.com/read/28646030/metabolic-remodelling-in-hypertrophied-and-failing-myocardium-a-review
#6
Mark Andrew Peterzan, Craig A Lygate, Stefan Neubauer, Oliver Rider
The energy starvation hypothesis proposes that maladaptive metabolic remodelling antedates, initiates and maintains adverse contractile dysfunction in heart failure (HF). Better understanding of the cardiac metabolic phenotype and metabolic signalling could help identify the role metabolic remodelling plays within HF and conditions known to transition toward HF, including 'pathological' hypertrophy. In this review, we discuss metabolic phenotype and metabolic signalling in the contexts of pathological hypertrophy and HF...
June 23, 2017: American Journal of Physiology. Heart and Circulatory Physiology
https://www.readbyqxmd.com/read/28643854/olfactory-dysfunction-in-the-app-ps1-transgenic-mouse-model-of-alzheimer-s-disease-morphological-evaluations-from-the-nose-to-the-brain
#7
Zhi-Gang Yao, Fang Hua, Hao-Zhuang Zhang, Yan-Yan Li, Ye-Jun Qin
Olfactory dysfunction is among the signs of Alzheimer's disease (AD) and cognitive impairment. It has been demonstrated Aβ was associated with olfactory impairment observed in both transgenic mice and in AD patients. In this study, we evaluated amyloid deposition in the olfactory circuit of APP/PS1 transgenic mouse model of AD, which showed olfactory dysfunction in olfactory behavior tests. We found amyloid depositions were widely distributed in the whole olfactory circuit. Moreover, we think these amyloid depositions contribute to neuronal atrophy, dendritic abnormalities, synapse loss and axonal degeneration...
June 23, 2017: Neuropathology: Official Journal of the Japanese Society of Neuropathology
https://www.readbyqxmd.com/read/28627729/the-immune-deficiency-of-chromosome-22q11-2-deletion-syndrome
#8
Megan Morsheimer, Terri F Brown Whitehorn, Jennifer Heimall, Kathleen E Sullivan
The syndrome originally described by Dr. Angelo DiGeorge had immunodeficiency as a central component. When a 22q11.2 deletion was identified as the cause in the majority of patients with DiGeorge syndrome, the clinical features of 22q11.2 deletion syndrome became so expansive that the immunodeficiency became less prominent in our thinking about the syndrome. This review will focus on the immune system and the changes in our understanding over the past 50 years. Initially characterized as a pure defect in T cell development, we now appreciate that many of the clinical features related to the immunodeficiency are well downstream of the limitation imposed by a small thymus...
June 19, 2017: American Journal of Medical Genetics. Part A
https://www.readbyqxmd.com/read/28614817/shifting-focus-from-hydration-for-performance-to-hydration-for-health
#9
Erica T Perrier
Over the past 10 years, literature on hydration biomarkers has evolved considerably - from (de)hydration assessment towards a more global definition of biomarkers of hydration in daily life. This shift in thinking about hydration markers was largely driven by investigating the differences that existed between otherwise healthy individuals whose habitual, ad-libitum drinking habits differ, and by identifying physiological changes in low-volume drinkers who subsequently increase their water intake. Aside from obvious differences in urinary volume and concentration, a growing body of evidence is emerging that links differences in fluid intake with small, but biologically significant, differences in vasopressin (copeptin), glomerular filtration rate, and markers of metabolic dysfunction or disease...
2017: Annals of Nutrition & Metabolism
https://www.readbyqxmd.com/read/28604073/-fear-and-avoidance-beliefs-in-chronic-pain-the-translation-and-validation-of-the-hungarian-version-of-the-fabq-questionnaire
#10
Eszter Simoncsics, Adrienne Stauder
INTRODUCTION: Chronic low back pain is one of the top reasons for seeking medical advice. In the background of the dysfunction besides the somatic pain dysfunctional thinking, negative emotional states, or interpersonal problems can be identified as well. One of the most important factors making the rehabilitation difficult is the fear and avoidance of physical activity. AIM: The aim of the study was to adapt and validate the Fear Avoidance Beliefs Questionnaire (FABQ-H) in Hungarian...
June 2017: Orvosi Hetilap
https://www.readbyqxmd.com/read/28602030/variable-expressivity-of-a-likely-pathogenic-variant-in-kcnq2-in-a-three-generation-pedigree-presenting-with-intellectual-disability-with-childhood-onset-seizures
#11
Stacy Hewson, Klajdi Puka, Saadet Mercimek-Mahmutoglu
KCNQ2 has been reported as a frequent cause of autosomal dominant benign familial neonatal seizures. De novo likely pathogenic variants in KCNQ2 have been described in neonatal or early infantile onset epileptic encephalopathy patients. Here, we report a three-generation family with six affected patients with a novel likely pathogenic variant (c.628C>T; p.Arg210Cys) in KCNQ2. Four family members, three adults and a child, presented with a childhood seizure onset with variability in the severity of seizures and response to treatment, intellectual disability (ID) as well as behavioral problems...
June 11, 2017: American Journal of Medical Genetics. Part A
https://www.readbyqxmd.com/read/28582650/magical-thinking-and-decision-making-strategies-among-late-adolescent-regular-gamblers-a-mediation-model
#12
Alessia Passanisi, Giuseppe Craparo, Ugo Pace
In the present study, the relation between the tendency to seek supernatural connections between external events and one's own thoughts, words, and actions and gambling among late adolescents has been studied. Psychologists have called this tendency magical thinking. The principal aim of the present study was to test the fit of an explanatory model of risk that starts from magical thinking and passes through maladaptive decision-making strategies, culminating with pathological gambling. Two hundred twenty-two Italian late adolescents, regularly attending bingo halls, aged between 19 and 21 years, completed measures on magical thinking, decision-making strategies, and gambling...
August 2017: Journal of Adolescence
https://www.readbyqxmd.com/read/28578790/the-role-of-interneurons-in-autism-and-tourette-syndrome
#13
REVIEW
Maximiliano Rapanelli, Luciana Romina Frick, Christopher Pittenger
The brain includes multiple types of interconnected excitatory and inhibitory neurons that together allow us to move, think, feel, and interact with the environment. Inhibitory interneurons (INs) comprise a small, heterogeneous fraction, but they exert a powerful and tight control over neuronal activity and consequently modulate the magnitude of neuronal output and, ultimately, information processing. IN abnormalities are linked to two pediatric psychiatric disorders with high comorbidity: autism spectrum disorder (ASD) and Tourette syndrome (TS)...
July 2017: Trends in Neurosciences
https://www.readbyqxmd.com/read/28558878/the-neurobiology-of-depression-an-integrated-view
#14
REVIEW
Jason Dean, Matcheri Keshavan
Major Depressive Disorder (MDD) is one of the most common and debilitating mental disorders; however, its etiology remains unclear. This paper aims to summarize the major neurobiological underpinnings of depression, synthesizing the findings into a comprehensive integrated view. A literature review was conducted using Pubmed. Search terms included "depression" or "MDD" AND "biology", "neurobiology", "inflammation", "neurogenesis", "monoamine", and "stress". Articles from 1995 to 2016 were reviewed with a focus on the connection between different biological and psychological models...
June 2017: Asian Journal of Psychiatry
https://www.readbyqxmd.com/read/28518148/hepatocyte-polyploidization-and-its-association-with-pathophysiological-processes
#15
REVIEW
Min-Jun Wang, Fei Chen, Joseph T Y Lau, Yi-Ping Hu
A characteristic cellular feature of the mammalian liver is the progressive polyploidization of the hepatocytes, where individual cells acquire more than two sets of chromosomes. Polyploidization results from cytokinesis failure that takes place progressively during the course of postnatal development. The proportion of polyploidy also increases with the aging process or with cellular stress such as surgical resection, toxic stimulation, metabolic overload, or oxidative damage, to involve as much as 90% of the hepatocytes in mice and 40% in humans...
May 18, 2017: Cell Death & Disease
https://www.readbyqxmd.com/read/28492608/sinonasal-symptom-related-sleep-disorders-before-and-after-surgery-for-nasal-polyposis
#16
D T Nguyen, F Arous, P Gallet, M Felix-Ravelo, P L Nguyen-Thi, C Rumeau, R Jankowski
BACKGROUND: Patients with nasal polyposis (NP) complain of several sinonasal symptoms that impact their sleep and quality of life. However, data on sleep disorders related to NP symptoms, before and after surgery, is poor. The aim of the present study was to analyze sleep complaints related to each NP symptom, before and after surgery, using the Dynachron questionnaire. METHODOLOGY: 63 patients operated for NP were included in this prospective study. They filled the DyNaChron questionnaire one day before surgery (V0), 6 weeks (V1) and 7 months (V2) after surgery...
May 10, 2017: Rhinology
https://www.readbyqxmd.com/read/28488208/erythropoietin-rescues-memory-impairment-in-a-rat-model-of-chronic-cerebral-hypoperfusion-via-the-epo-r-jak2-stat5-pi3k-akt-gsk-3%C3%AE-pathway
#17
Shengli Ma, Juwu Chen, Chen Chen, Na Wei, Jingjing Xu, Guohui Yang, Nan Wang, Yu Meng, Jia Ren, Zongchao Xu
Vascular dementia is the second most common cause of dementia in older people and is characterized by the sudden onset of impairments in thinking skills and behavior, which generally occur following a stroke. Unfortunately, effective therapy for vascular dementia remains inadequate. Erythropoietin (EPO) is a glycoprotein hormone that controls erythropoiesis, or red blood cell production. Recently, a prominent role for EPO has been defined in the nervous system, and there is growing interest in the potential therapeutic use of EPO for neuroprotection...
May 9, 2017: Molecular Neurobiology
https://www.readbyqxmd.com/read/28466133/planning-functioning-and-impulsiveness-in-obsessive-compulsive-disorder
#18
Riccardo Maria Martoni, Roberta de Filippis, Stefania Cammino, Mattia Giuliani, Gaia Risso, Maria Cristina Cavallini, Laura Bellodi
Planning ability (PA) is a key aspect of cognitive functioning and requires subjects to identify and organise the necessary steps to achieve a goal. Despite the central role of executive dysfunction in patients with obsessive-compulsive disorder (OCD), deficits in PA have been investigated leading to contrasting results. Given these inconsistencies, the main aim of our work is to give a deeper and clearer understanding of PA in OCD patients. Moreover, we are interested in investigating the relationship between PAs and impulsivity traits and other clinical variables...
May 2, 2017: European Archives of Psychiatry and Clinical Neuroscience
https://www.readbyqxmd.com/read/28447827/interpersonal-dysfunction-in-personality-disorders-a-meta-analytic-review
#19
Sylia Wilson, Catherine B Stroud, C Emily Durbin
Personality disorders are defined in the current psychiatric diagnostic system as pervasive, inflexible, and stable patterns of thinking, feeling, behaving, and interacting with others. Questions regarding the validity and reliability of the current personality disorder diagnoses prompted a reconceptualization of personality pathology in the most recent edition of the psychiatric diagnostic manual, in an appendix of emerging models for future study. To evaluate the construct and discriminant validity of the current personality disorder diagnoses, we conducted a quantitative synthesis of the existing empirical research on associations between personality disorders and interpersonal functioning, defined using the interpersonal circumplex model (comprising orthogonal dimensions of agency and communion), as well as functioning in specific relationship domains (parent-child, family, peer, romantic)...
July 2017: Psychological Bulletin
https://www.readbyqxmd.com/read/28444715/can-a-patient-reported-outcome-be-adequate-without-assessing-quality-of-life-in-lower-urinary-tract-dysfunction
#20
REVIEW
Nikki Cotterill, Andrea Tubaro
AIMS AND METHODS: A think tank was convened at the sixth ICI-RS meeting held in the United Kingdom on September 2015, to consider the adequacy of patient reported outcome (PRO) measurement if quality of life (QoL) evaluation were excluded. Rigorous methodology is proposed for the development of PROs and much is written about this process but the necessity for QoL inclusion is rarely discussed. The decision was therefore taken to consider what QoL evaluation provides and what these data provide...
April 2017: Neurourology and Urodynamics
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