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https://www.readbyqxmd.com/read/29236142/frequency-dependent-growth-in-class-structured-populations-continuous-dynamics-in-the-limit-of-weak-selection
#1
Sabin Lessard, Cíntia Dalila Soares
In this paper we consider class-structured populations in discrete time in the limit of weak selection and with the inverse of the intensity of selection as unit of time. The aim is to establish a continuous model that approximates the discrete model. More precisely, we study frequency-dependent growth in an infinite haploid population structured into a finite number of classes such that individuals in each class contribute to a given subset of classes from one time step to the next. These contributions take the form of generalized fecundity parameters with perturbations of order 1 / N that depends on the class frequencies of each type and the type frequencies...
December 13, 2017: Journal of Mathematical Biology
https://www.readbyqxmd.com/read/29235659/effect-of-metabolic-syndrome-on-late-life-depression-associations-with-disease-severity-and-treatment-resistance
#2
John S Mulvahill, Ginger E Nicol, David Dixon, Eric J Lenze, Jordan F Karp, Charles F Reynolds, Daniel M Blumberger, Benoit H Mulsant
BACKGROUND/OBJECTIVES: Metabolic syndrome (MetS) is the co-occurrence of obesity and metabolic derangements. Prior research implicates MetS in prolongation of the course of depression in older adults, but its effect on antidepressant response is unknown in this population. The objective was to determine whether MetS and related metabolic dyscrasias are associated with decreased rate of remission from depression in older adults treated pharmacologically for depression. DESIGN: Secondary analysis of a randomized controlled trial...
December 2017: Journal of the American Geriatrics Society
https://www.readbyqxmd.com/read/29235208/optical-coherence-tomography-for-assessment-of-epithelialization-in-a-human-ex-vivo-wound-model
#3
George D Glinos, Sebastian H Verne, Adam S Aldahan, Liang Liang, Keyvan Nouri, Sharon Elliot, Marilyn Glassberg, Delia Cabrera DeBuc, Tulay Koru-Sengul, Marjana Tomic-Canic, Irena Pastar
The ex vivo human skin wound model is a widely accepted model to study wound epithelialization. Due to a lack of animal models that fully replicate human conditions, the ex vivo model is a valuable tool to study mechanisms of wound re-epithelialization, as well as for pre-clinical testing of novel therapeutics. The current standard for assessment of wound healing in this model is histomorphometric analysis, which is labor intensive, time consuming, and requires multiple biological and technical replicates in addition to assessment of different time points...
December 13, 2017: Wound Repair and Regeneration
https://www.readbyqxmd.com/read/29235143/allostatic-load-but-not-medical-burden-predicts-memory-performance-in-late-life-bipolar-disorder
#4
REVIEW
Sophie R Vaccarino, Tarek K Rajji, Ariel G Gildengers, Sarah E S Waters, Meryl A Butters, Mahesh Menon, Daniel M Blumberger, Aristotle N Voineskos, Dielle Miranda, Benoit H Mulsant
OBJECTIVE: Older patients with bipolar disorder (BD) present with variable degrees of cognitive impairment. Over time, stress, mood episodes, and comorbidities increase the body's allostatic load. We assessed the extent to which allostatic load vs more traditional measures of medical burden account for the heterogeneity in cognition in this population. METHODS: Thirty-five older euthymic patients with BD and 30 age-equated, gender-equated, and education-equated comparison participants were administered a comprehensive assessment including a neuropsychological battery, and 9 physiological measures to determine allostatic load...
December 13, 2017: International Journal of Geriatric Psychiatry
https://www.readbyqxmd.com/read/29234348/diurnal-transcriptome-and-gene-network-represented-through-sparse-modeling-in-brachypodium-distachyon
#5
Satoru Koda, Yoshihiko Onda, Hidetoshi Matsui, Kotaro Takahagi, Yukiko Yamaguchi-Uehara, Minami Shimizu, Komaki Inoue, Takuhiro Yoshida, Tetsuya Sakurai, Hiroshi Honda, Shinto Eguchi, Ryuei Nishii, Keiichi Mochida
We report the comprehensive identification of periodic genes and their network inference, based on a gene co-expression analysis and an Auto-Regressive eXogenous (ARX) model with a group smoothly clipped absolute deviation (SCAD) method using a time-series transcriptome dataset in a model grass, Brachypodium distachyon. To reveal the diurnal changes in the transcriptome in B. distachyon, we performed RNA-seq analysis of its leaves sampled through a diurnal cycle of over 48 h at 4 h intervals using three biological replications, and identified 3,621 periodic genes through our wavelet analysis...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/29234115/the-glutamic-residue-at-position-402-in-the-c-terminus-of-newcastle-disease-virus-nucleoprotein-is-critical-for-the-virus
#6
Xiaohui Yu, Jinlong Cheng, Zirong He, Chuang Li, Yang Song, Jia Xue, Huiming Yang, Rui Zhang, Guozhong Zhang
The nucleocapsid proteins (NPs) of Newcastle disease virus (NDV) and other paramyxoviruses play an important functional role during genomic RNA replication. Our previous study showed that the NP-encoding gene significantly influenced viral replication. Here, we investigated the roles of certain amino acid residues in the NP C-terminus in viral replication and virulence. Results showed that the glutamic acid residue at position 402 (E402) in the C-terminus of the NP is critical for RNA synthesis in the NDV mini-genome system...
December 12, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29233523/stereotactic-body-radiation-therapy-for-stage-i-non-small-cell-lung-cancer-the-importance-of-treatment-planning-algorithm-and-evaluation-of-a-tumor-control-probability-model
#7
Nitin Ohri, Wolfgang Tomé, Shalom Kalnicki, Madhur Garg
BACKGROUND: Stereotactic body radiation therapy (SBRT) is increasingly used to treat early-stage non-small cell lung cancer (NSCLC). A previous report introduced the term size-adjusted biologically effective dose (sBED), which accounts for tumor diameter and biologically effective dose (BED) and may be used to predict the likelihood of local control following SBRT. Here we seek to replicate those findings using a separate dataset. METHODS AND MATERIALS: We queried the RSSearch Patient Registry for patients treated with SBRT for stage I NSCLC...
October 7, 2017: Practical Radiation Oncology
https://www.readbyqxmd.com/read/29233216/nucleic-acids-function-and-potential-for-abiogenesis
#8
Falk Wachowius, James Attwater, Philipp Holliger
The emergence of functional cooperation between the three main classes of biomolecules - nucleic acids, peptides and lipids - defines life at the molecular level. However, how such mutually interdependent molecular systems emerged from prebiotic chemistry remains a mystery. A key hypothesis, formulated by Crick, Orgel and Woese over 40 year ago, posits that early life must have been simpler. Specifically, it proposed that an early primordial biology lacked proteins and DNA but instead relied on RNA as the key biopolymer responsible not just for genetic information storage and propagation, but also for catalysis, i...
January 2017: Quarterly Reviews of Biophysics
https://www.readbyqxmd.com/read/29233093/physiological-and-transcriptomic-responses-in-the-seed-coat-of-field-grown-soybean-glycine-max-l-merr-to-abiotic-stress
#9
Courtney P Leisner, Craig R Yendrek, Elizabeth A Ainsworth
BACKGROUND: Understanding how intensification of abiotic stress due to global climate change affects crop yields is important for continued agricultural productivity. Coupling genomic technologies with physiological crop responses in a dynamic field environment is an effective approach to dissect the mechanisms underpinning crop responses to abiotic stress. Soybean (Glycine max L. Merr. cv. Pioneer 93B15) was grown in natural production environments with projected changes to environmental conditions predicted for the end of the century, including decreased precipitation, increased tropospheric ozone concentrations ([O3]), or increased temperature...
December 12, 2017: BMC Plant Biology
https://www.readbyqxmd.com/read/29231255/the-structural-and-functional-reliability-of-circulins-of-chassalia-parvifolia-for-peptide-therapeutic-scaffolding
#10
B Senthilkumar, R Rajasekaran
Computational methods have refined the mode of peptide drug designing to a new plateau recently. Circulin, a 30 residue natural plant polypeptide acts as a plant defensive peptide. Additional to its antimicrobial activity it also possesses an inhibitory cytopathic effect on the replication of human immunodeficiency virus (HIV). Stable Circulin can be a functionally able template for scaffolding peptide based drugs. Hence, structural stability of Chassalia parvifolia, Circulin A (1BH4) and Circulin B (2ERI) was computationally investigated...
December 12, 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/29230903/nurse-manager-succession-planning-a-cost-benefit-analysis
#11
Tracy Phillips, Jennifer L Evans, Stephanie Tooley, Maria R Shirey
AIM: This commentary presents a cost-benefit analysis to advocate for the use of succession planning to mitigate the problems ensuing from nurse manager turnover. BACKGROUND: An estimated 75% of nurse managers will leave the workforce by 2020. Many benefits are associated with proactively identifying and developing internal candidates. Fewer than 7% of health care organisations have implemented formal leadership succession planning programmes. EVALUATION: A cost-benefit analysis of a formal succession-planning programme from one hospital illustrates the benefits of the programme in their organisation and can be replicated easily...
December 12, 2017: Journal of Nursing Management
https://www.readbyqxmd.com/read/29230392/non-invasive-monitoring-of-cardiac-output-in-critical-care-medicine
#12
REVIEW
Lee S Nguyen, Pierre Squara
Critically ill patients require close hemodynamic monitoring to titrate treatment on a regular basis. It allows administering fluid with parsimony and adjusting inotropes and vasoactive drugs when necessary. Although invasive monitoring is considered as the reference method, non-invasive monitoring presents the obvious advantage of being associated with fewer complications, at the expanse of accuracy, precision, and step-response change. A great many methods and devices are now used over the world, and this article focuses on several of them, providing with a brief review of related underlying physical principles and validation articles analysis...
2017: Frontiers in Medicine
https://www.readbyqxmd.com/read/29229755/the-full-moon-and-motorcycle-related-mortality-population-based-double-control-study
#13
Donald A Redelmeier, Eldar Shafir
OBJECTIVE: To test whether a full moon contributes to motorcycle related deaths. DESIGN: Population based, individual level, double control, cross sectional analysis. SETTING: Nighttime (4 pm to 8 am), United States. PARTICIPANTS: 13 029 motorcycle fatalities throughout the United States, 1975 to 2014 (40 years). MAIN OUTCOME MEASURE: Motorcycle fatalities during a full moon. RESULTS: 13 029 motorcyclists were in fatal crashes during 1482 relevant nights...
December 11, 2017: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/29229671/h3s10ph-broadly-marks-early-replicating-domains-in-interphase-escs-and-shows-reciprocal-antagonism-with-h3k9me2
#14
Carol C L Chen, Preeti Goyal, Mohammad M Karimi, Marie H Abildgaard, Hiroshi Kimura, Matthew C Lorincz
Phosphorylation of histone H3 at serine 10 (H3S10ph) by Aurora kinases plays an important role in mitosis; however, H3S10ph also marks regulatory regions of inducible genes in interphase mammalian cells, implicating mitosis-independent functions. Using the fluorescent ubiquitin-mediated cell cycle indicator (FUCCI), we found that 30% of the genome in interphase mouse embryonic stem cells (ESCs) is marked with H3S10ph. H3S10ph broadly demarcates gene-rich regions in G1 and is positively correlated with domains of early DNA replication timing (RT) but negatively correlated with H3K9me2 and lamin-associated domains (LADs)...
December 11, 2017: Genome Research
https://www.readbyqxmd.com/read/29228684/atorvastatin-downregulates-co-inhibitory-receptor-expression-by-targeting-ras-activated-mtor-signalling
#15
Isobel Okoye, Afshin Namdar, Lai Xu, Nicole Crux, Shokrollah Elahi
Regulation of T cell function in the steady state is mediated by co-inhibitory receptors or immune checkpoints such as PD-1, CTLA-4, TIM-3 and LAG-3. Persistent antigen stimulation, during chronic viral infections and cancer, results in sustained expression of multiple co-inhibitory receptors and subsequently poor effector T cell function. Immune checkpoint blockade using monoclonal antibodies against PD-1, PDL-1 and CTLA-4 has been implemented as an immunotherapy strategy- resulting in restoration of T cell function and reduction of viral load or tumour growth...
November 17, 2017: Oncotarget
https://www.readbyqxmd.com/read/29228600/non-invasive-in-vivo-molecular-imaging-of-intra-articularly-transplanted-immortalized-bone-marrow-stem-cells-for-osteoarthritis-treatment
#16
Bou-Yue Peng, Chi-Sheng Chiou, Navneet Kumar Dubey, Sung-Hsun Yu, Yue-Hua Deng, Feng-Chou Tsai, Han-Sun Chiang, Ying-Hua Shieh, Wei-Hong Chen, Win-Ping Deng
Pathophysiology of osteoarthritis (OA) is characterized by progressive loss of articular cartilage in the knee-joints. To impart regenerative ability in lowly metabolizing chondrocytes, the bone marrow stem cells (BMSCs) has recently been recognized as a superior alternative treatment for OA. However, study of primary BMSCs-mediated chondrogenesis is difficult due to progressive cellular aging and replicative senescence. To obtain a therapeutic cell population for OA, BMSCs were immortalized by human papilloma virus (HPV)-16 E6/E7 along with mCherry luciferase (mCL), a gene marker for non-invasive imaging, and designated as iBMSCs-mCL...
November 14, 2017: Oncotarget
https://www.readbyqxmd.com/read/29228551/human-cytomegalovirus-and-herpes-simplex-type-i-virus-can-engage-rna-polymerase-i-for-transcription-of-immediate-early-genes
#17
Ourania N Kostopoulou, Vanessa Wilhelmi, Sina Raiss, Sharan Ananthaseshan, Mikael S Lindström, Jiri Bartek, Cecilia Söderberg-Naucler
Human cytomegalovirus (HCMV) utilizes RNA polymerase II to transcribe viral genes and produce viral mRNAs. It can specifically target the nucleolus to facilitate viral transcription and translation. As RNA polymerase I (Pol I)-mediated transcription is active in the nucleolus, we investigated the role of Pol I, along with relative contributions of the human Pol II and Pol III, to early phases of viral transcription in HCMV infected cells, compared with Herpes Simplex Virus-1 (HSV-1) and Murine cytomegalovirus (MCMV)...
November 14, 2017: Oncotarget
https://www.readbyqxmd.com/read/29227989/non-linear-auto-regressive-models-for-cross-frequency-coupling-in-neural-time-series
#18
Tom Dupré la Tour, Lucille Tallot, Laetitia Grabot, Valérie Doyère, Virginie van Wassenhove, Yves Grenier, Alexandre Gramfort
We address the issue of reliably detecting and quantifying cross-frequency coupling (CFC) in neural time series. Based on non-linear auto-regressive models, the proposed method provides a generative and parametric model of the time-varying spectral content of the signals. As this method models the entire spectrum simultaneously, it avoids the pitfalls related to incorrect filtering or the use of the Hilbert transform on wide-band signals. As the model is probabilistic, it also provides a score of the model "goodness of fit" via the likelihood, enabling easy and legitimate model selection and parameter comparison; this data-driven feature is unique to our model-based approach...
December 11, 2017: PLoS Computational Biology
https://www.readbyqxmd.com/read/29227209/simultaneous-determination-of-organochlorine-and-pyrethriod-pesticide-residues-in-the-chinese-patent-medicines-by-gas-chromatography-tandem-mass-spectrometry
#19
Xue J Mao, Yao Zhong, Ai P Yan, Bin Wang, Yuan X Wang, Yi Q Wan
A simple, sensitive, reliable method was developed for the simultaneous determination of organochlorine and pyrethriod pesticide residues in Chinese patent medicines Six ingredient rehmannia pills and Xiaoyao pills. These pesticides were extracted by ethyl acetate. The extraction time and volume of ethyl acetate were optimized. Cleanup of extracts was performed with dispersive-solid phase extraction using graphitized carbon black as the sorbent. The determination of pesticides in the final extracts was carried out by gas chromatography-tandem mass spectrometry in multiple reaction monitoring mode (GC-MS/MS, MRM)...
December 11, 2017: Journal of Environmental Science and Health. Part. B, Pesticides, Food Contaminants, and Agricultural Wastes
https://www.readbyqxmd.com/read/29226961/detection-of-deception-event-related-potential-markers-of-attention-and-cognitive-control-during-intentional-false-responses
#20
Henning Gibbons, Robert Schnuerch, Christina Wittinghofer, Anne-Simone Armbrecht, Jutta Stahl
Successful deception requires the coordination of multiple mental processes, such as attention, conflict monitoring, and the regulation of emotion. We employed a simple classification task, assessing ERPs to further investigate the attentional and cognitive control components of (instructed) deception. In Experiment 1, 20 participants repeatedly categorized visually presented names of five animals and five plants. Prior to the experiment, however, each participant covertly selected one animal and one plant for deliberate misclassification...
December 11, 2017: Psychophysiology
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