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https://www.readbyqxmd.com/read/28821942/rapid-detection-of-serratia-fonticola-by-taqman-quantitative-real-time-pcr-using-primers-targeting-the-gyrb-gene
#1
Jing Hua Ruan, Wu Jun Wang, Ti Yin Zhang, Quan Yang Bai, Teng Zheng, Zhi Deng Zhang, Li Yun Wu, Yi Fan Huang, Dao Jin Yu
A gyrB gene is present in the majority of bacterial species, and encodes the ATPase domain of DNA gyraseB-subunit protein, which is essential for transcription and replication of bacteria. The gyrB gene exhibits higher nucleotide sequence variability than the 16S rDNA gene and thus could be more reliable in differentiating Serratia fonticola. A species-specific primer pair and probe were designed for quantitative real-time PCR detection of S. fonticola using gyrB as the target gene. Nine members of the Serratia family (representing nine Serratia species) were chosen to verify the specificity of the primers...
August 18, 2017: Current Microbiology
https://www.readbyqxmd.com/read/28821668/sensory-biased-and-multiple-demand-processing-in-human-lateral-frontal-cortex
#2
Abigail L Noyce, Nishmar Cestero, Samantha W Michalka, Barbara G Shinn-Cunningham, David C Somers
The functionality of much of human lateral frontal cortex (LFC) has been characterized as 'multiple demand' as these regions appear to support a broad range of cognitive tasks. In contrast to this domain-general account, recent evidence indicates that portions of LFC are consistently selective for sensory modality. Michalka et al. (2015) reported two bilateral regions that are biased for visual attention, superior precentral sulcus (sPCS) and inferior precentral sulcus (iPCS), interleaved with two bilateral regions that are biased for auditory attention, transverse gyrus intersecting precentral sulcus (tgPCS) and caudal inferior frontal sulcus (cIFS)...
August 8, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/28821622/the-replication-and-transcription-activator-of-murine-gammaherpesvirus-68-cooperatively-enhances-cytokine-activated-stat3-mediated-gene-expression
#3
Hui-Chen Chang Foreman, Julie Armstrong, Alexis L Santana, Laurie T Krug, Nancy C Reich
Gammaherpesviruses (γΗVs) have a dynamic strategy for life-time persistence, involving productive infection, latency, and intermittent reactivation. In latency reservoirs, such as B lymphocytes, γΗV exists as a viral episome and expresses few viral genes. Although the ability of γHV to reactivate from latency and re-enter the lytic phase is challenging to investigate and control, it is known that the γΗV replication and transcription activator, RTA, can promote lytic reactivation. In this study, we provide first evidence that RTA of murine γΗV 68 (MHV68) selectively binds and enhances the activity of tyrosine-phosphorylated host STAT3...
August 15, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28820396/the-role-of-mtor-inhibitors-and-hmg-coa-reductase-inhibitors-on-young-and-old-endothelial-cell-functions-critical-for-re-endothelialisation-after-percutaneous-coronary-intervention-an-in-vitro-study
#4
K Korybalska, E Kawka, A Breborowicz, J Witowski
Percutaneous coronary intervention (PCI) has become a standard treatment in patients with acute coronary syndrome. However, it is associated with endothelial cell denudation, which may predispose to in-stent thrombosis and restenosis. Pharmacological methods which prevent restenosis can delay post-PCI re-endothelialisation. We have therefore examined how atorvastatin (HMG-CoA reductase inhibitor), sirolimus and everolimus (mTOR inhibitors) affect young and old endothelial cell functions which are responsible for wound healing after PCI...
June 2017: Journal of Physiology and Pharmacology: An Official Journal of the Polish Physiological Society
https://www.readbyqxmd.com/read/28820067/a-comprehensive-review-on-ebola-ebov-virus-future-prospects
#5
Dr Abdru Rauf, Muhammad, Abdur Rauf, Ahsan Khan, Muhammad Rizwan, Seema Patel, Haroon Khan, Adel Mahasneh, Mohammad S Mubarak
Ebola virus (EBOV) was discovered for the first time in 1976. It belongs to the family Filoviridae, which causes hemorrhagic fever that could lead to death in a few days. West Africa faced a major outbreak where symptoms appeared in the form of chills, myalgia, fever, diarrhea, and vomiting, and the disease finally reached a severe state as a result of hemorrhagic complications and failure of multiple organs. EBOV spreads by contact with body fluids of an infected person such as blood, saliva, urine, and seminal fluid, and also spreads by a contact with contaminated surfaces...
August 16, 2017: Infectious Disorders Drug Targets
https://www.readbyqxmd.com/read/28819995/the-effect-of-different-fish-feed-compositions-on-%C3%AE-13-c-and-%C3%AE-15-n-signatures-of-sea-bass-and-its-potential-value-for-tracking-mariculture-derived-nutrients
#6
Henrik Kusche, Nicola Hillgruber, Yvonne Rößner, Ulfert Focken
Increasing demand for fish and seafood calls for an expansion of aquaculture production. At the same time, the status of the marine environment must not be jeopardised. Stable isotopes are potential markers for tracking feed-based nutrient flows from aquaculture into marine biota. Here, we demonstrate how four experimental diets (main protein components: fishmeal, soya protein concentrate, wheat gluten, and Jatropha kernel meal) and a commercial diet induce characteristic δ(13)C and δ(15)N signals in sea bass (Dicentrarchus labrax) during nine weeks of laboratory feeding under replicate conditions...
August 18, 2017: Isotopes in Environmental and Health Studies
https://www.readbyqxmd.com/read/28819926/targeting-metabolic-pathways-for-head-and-neck-cancers-therapeutics
#7
Masashi Yamamoto, Hidenori Inohara, Takashi Nakagawa
Cancer cells have distinctive energy metabolism pathways that support their rapid cell division. The preference for anaerobic glycolysis under the normal oxygen condition is known as the Warburg effect and has been observed in head and neck cancers. These metabolic changes are controlled by cancer-related transcription factors, such as tumor suppressor gene and hypoxia inducible factor 1α. In addition, various metabolic enzymes also actively regulate cancer-specific metabolism including the switch between aerobic and anaerobic glycolysis...
August 17, 2017: Cancer Metastasis Reviews
https://www.readbyqxmd.com/read/28819922/therapeutic-alliance-client-need-for-approval-and-perfectionism-as-differential-moderators-of-response-to-ehealth-and-traditionally-delivered-treatments-for-comorbid-depression-and-substance-use-problems
#8
Frances J Kay-Lambkin, Amanda L Baker, Kerrin Palazzi, Terry J Lewin, Brian J Kelly
PURPOSE: This study sought to undertake an exploratory analysis of the impact of therapeutic alliance and dysfunctional attitudes (perfectionism and need for approval) on outcomes for participants receiving therapist-delivered and eHealth interventions for comorbid depression and alcohol/cannabis use problems. These factors have been shown in previous research to moderate response to psychological treatment for depression and related disorders. METHOD: Participants (N = 274) with concurrent depression and alcohol/cannabis misuse were randomized to 10 sessions of therapist-delivered cognitive behavior therapy/motivational interviewing (CBT/MI), computer-delivered CBT/MI with brief therapist assistance (SHADE CBT/MI), or supportive counseling (PCT)...
August 17, 2017: International Journal of Behavioral Medicine
https://www.readbyqxmd.com/read/28819329/efficient-computation-of-electrograms-and-ecgs-in-human-whole-heart-simulations-using-a-reaction-eikonal-model
#9
Aurel Neic, Fernando O Campos, Anton J Prassl, Steven A Niederer, Martin J Bishop, Edward J Vigmond, Gernot Plank
Anatomically accurate and biophysically detailed bidomain models of the human heart have proven a powerful tool for gaining quantitative insight into the links between electrical sources in the myocardium and the concomitant current flow in the surrounding medium as they represent their relationship mechanistically based on first principles. Such models are increasingly considered as a clinical research tool with the perspective of being used, ultimately, as a complementary diagnostic modality. An important prerequisite in many clinical modeling applications is the ability of models to faithfully replicate potential maps and electrograms recorded from a given patient...
October 1, 2017: Journal of Computational Physics
https://www.readbyqxmd.com/read/28818113/respiratory-syncytial-virus-rsv-entry-is-inhibited-by-serine-protease-inhibitor-aebsf-when-present-during-an-early-stage-of-infection
#10
Winke Van der Gucht, Annelies Leemans, Marjorie De Schryver, Annick Heykers, Guy Caljon, Louis Maes, Paul Cos, Peter L Delputte
BACKGROUND: Host proteases have been shown to play important roles in many viral activities such as entry, uncoating, viral protein production and disease induction. Therefore, these cellular proteases are putative targets for the development of antivirals that inhibit their activity. Host proteases have been described to play essential roles in Ebola, HCV, HIV and influenza, such that specific protease inhibitors are able to reduce infection. RSV utilizes a host protease in its replication cycle but its potential as antiviral target is unknown...
August 17, 2017: Virology Journal
https://www.readbyqxmd.com/read/28817699/cooperative-dynamics-of-neighborhood-economic-status-in-cities
#11
Anand Sahasranaman, Henrik Jeldtoft Jensen
We significantly extend our earlier variant of the Schelling model, incorporating a neighborhood Potential function as well as an agent wealth gain function to study the long term evolution of the economic status of neighborhoods in cities. We find that the long term patterns of neighborhood relative economic status (RES) simulated by this model reasonably replicate the empirically observed patterns from American cities. Specifically, we find that larger fractions of rich and poor neighborhoods tend to, on average, retain status for longer than lower- and upper-middle wealth neighborhoods...
2017: PloS One
https://www.readbyqxmd.com/read/28817615/genotoxic-effects-of-roundup-full-ii%C3%A2-on-lymphocytes-of-chaetophractus-villosus-xenarthra-mammalia-in-vitro-studies
#12
Juan Pablo Luaces, Luis Francisco Rossi, Mónica Gabriela Chirino, Melanie Browne, María Susana Merani, Marta Dolores Mudry
In Argentina, Chaetophractus villosus has a wide distribution that overlaps with agricultural areas where soybean is the predominant crop. In such areas the pesticide Roundup Full II® (RU) is widely applied. The genotoxic effect of its active ingredient glyphosate (RU is 66.2% glyphosate) on the peripheral blood lymphocytes of C. villosus was tested over a range of concentrations (280, 420, 560, 1120 μmol/L). Culture medium without glyphosate served as negative control, while medium containing mitomycin C served as positive control...
2017: PloS One
https://www.readbyqxmd.com/read/28817193/response-reinforcer-dependency-and-resistance-to-change
#13
Carlos R X Cançado, Josele Abreu-Rodrigues, Raquel Moreira Aló, Flávia Hauck, Adam H Doughty
The effects of the response-reinforcer dependency on resistance to change were studied in three experiments with rats. In Experiment 1, lever pressing produced reinforcers at similar rates after variable interreinforcer intervals in each component of a two-component multiple schedule. Across conditions, in the fixed component, all reinforcers were response-dependent; in the alternative component, the percentage of response-dependent reinforcers was 100, 50 (i.e., 50% response-dependent and 50% response-independent) or 10% (i...
August 17, 2017: Journal of the Experimental Analysis of Behavior
https://www.readbyqxmd.com/read/28815758/detection-of-cyprinid-herpesvirus-1-dna-in-cutaneous-squamous-cell-carcinoma-of-koi-carp-cyprinus-carpio
#14
Rubina Sirri, Sara Ciulli, Tim Barbé, Enrico Volpe, Maurizio Lazzari, Valeria Franceschini, Francesca Errani, Giuseppe Sarli, Luciana Mandrioli
BACKGROUND: Cutaneous squamous cell carcinoma (cSCC) is an uncommon disease affecting koi carp (Cyprinus carpio). Cutaneous papilloma (carp pox) is a benign epidermal proliferation reported in koi and has been shown to be caused by Cyprinid Herpesvirus 1 (CyHV1). HYPOTHESIS/OBJECTIVES: Histological, ultrastructural and molecular investigations were carried out aiming to investigate the aetiology of cSCC within archived tissue samples. ANIMALS: Surgical samples of masses located on the integument, fins and lips of 13 koi carp belonging to different private owners were included in this retrospective study...
August 16, 2017: Veterinary Dermatology
https://www.readbyqxmd.com/read/28815403/overexpression-of-topoisomerase-2-alpha-confers-a-poor-prognosis-in-pancreatic-adenocarcinoma-identified-by-co-expression-analysis
#15
Zhou Zhou, Shi Liu, Meng Zhang, Rui Zhou, Jing Liu, Ying Chang, Qiu Zhao
BACKGROUND: Pancreatic ductal adenocarcinoma (PDAC) is the fourth most common cause of human cancer-related death in the developed countries. Its progression and prognosis are influenced by a complex network of gene interactions. AIMS: The purpose of this study is to explore key genes associated with pancreatic ductal adenocarcinoma and to predict the possible mechanisms. METHODS: A weighted gene co-expression network was constructed to identify gene modules associated with the progression of PDAC...
August 16, 2017: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/28815262/semantic-and-phonological-encoding-in-adults-who-stutter-silent-responses-to-pictorial-stimuli
#16
Irena Vincent
Purpose: Research on language planning in adult stuttering is relatively sparse and offers diverging arguments about a potential causative relationship between semantic and phonological encoding and fluency breakdowns. This study further investigated semantic and phonological encoding efficiency in adults who stutter (AWS) by means of silent category and phoneme identification, respectively. Method: Fifteen AWS and 15 age- and sex-matched adults who do not stutter (ANS) participated...
August 16, 2017: Journal of Speech, Language, and Hearing Research: JSLHR
https://www.readbyqxmd.com/read/28814733/enhancing-immune-responses-to-cancer-vaccines-using-multi-site-injections
#17
Robert C Mould, Amanda W K AuYeung, Jacob P van Vloten, Leonardo Susta, Anthony J Mutsaers, James J Petrik, Geoffrey A Wood, Sarah K Wootton, Khalil Karimi, Byram W Bridle
For a vaccine to be effective it must induce a sufficiently robust and specific immune response. Multi-site injection protocols can increase the titers of rabies virus-neutralizing antibodies. Hypothetically, spreading a vaccine dose across multiple lymphatic drainage regions could also potentiate T cell responses. We used a replication-deficient adenovirus serotype 5-vectored cancer vaccine targeting the melanoma-associated antigen dopachrome tautomerase. Clinically, high numbers of tumor-infiltrating CD8(+) T cells are a positive prognostic indicator...
August 16, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28814528/physician-training-protocol-within-the-web-intrasaccular-therapy-web-it-study
#18
Adam Arthur, Daniel Hoit, Alexander Coon, Josser E Delgado Almandoz, Lucas Elijovich, Saruhan Cekirge, David Fiorella
INTRODUCTION: The WEB Intra-saccular Therapy (WEB-IT) trial is an investigational device exemption study to demonstrate the safety and effectiveness of the WEB device for the treatment of wide-neck bifurcation aneurysms. The neurovascular replicator (Vascular Simulations, Stony Brook, New York, USA) creates a physical environment that replicates patient-specific neurovascular anatomy and hemodynamic physiology, and allows devices to be implanted under fluoroscopic guidance. OBJECTIVE: To report the results of a unique neurovascular replicator-based training program, which was incorporated into the WEB-IT study to optimize technical performance and patient safety...
August 16, 2017: Journal of Neurointerventional Surgery
https://www.readbyqxmd.com/read/28814328/building-capacity-for-dissemination-and-implementation-research-one-university-s-experience
#19
Ross C Brownson, Enola K Proctor, Douglas A Luke, Ana A Baumann, Mackenzie Staub, Matthew T Brown, Mallory Johnson
BACKGROUND: While dissemination and implementation (D&I) science has grown rapidly, there is an ongoing need to understand how to build and sustain capacity in individuals and institutions conducting research. There are three inter-related domains for capacity building: people, settings, and activities. Since 2008, Washington University in St. Louis has dedicated significant attention and resources toward building D&I research capacity. This paper describes our process, challenges, and lessons with the goal of informing others who may have similar aims at their own institution...
August 16, 2017: Implementation Science: IS
https://www.readbyqxmd.com/read/28813902/hybrid-position-and-orientation-tracking-for-a-passive-rehabilitation-table-top-robot
#20
K K Wojewoda, P R Culmer, J F Gallagher, A E Jackson, M C Levesley
This paper presents a real time hybrid 2D position and orientation tracking system developed for an upper limb rehabilitation robot. Designed to work on a table-top, the robot is to enable home-based upper-limb rehabilitative exercise for stroke patients. Estimates of the robot's position are computed by fusing data from two tracking systems, each utilizing a different sensor type: laser optical sensors and a webcam. Two laser optical sensors are mounted on the underside of the robot and track the relative motion of the robot with respect to the surface on which it is placed...
July 2017: IEEE ... International Conference on Rehabilitation Robotics: [proceedings]
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