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https://www.readbyqxmd.com/read/29028372/the-effect-of-latanaprost-on-intraocular-inflammation-and-macular-edema
#1
M Reza Razeghinejad
There is debate concerning whether the use of Latanoprost in early postoperative period of cataract surgery and in glaucoma patients with uveitis as it may aggravate the inflammation and results in macular edema (ME), because of blood-ocular barrier disruption. However, there is no solid evidence for disruption of blood-ocular barrier with Latanoprost and aggravation of uveitis or ME formation. Similar to pseudophakic ME, the imaging ME in cases claimed to be secondary to Latanoprost is greater than clinical ME, happens mostly in complicated surgeries, and the vast majority resolve within weeks to months with using a non-steroidal anti-inflammatory drug...
October 13, 2017: Ocular Immunology and Inflammation
https://www.readbyqxmd.com/read/29028357/folate-peg-nota-al18f-a-new-folate-based-radiotracer-for-pet-imaging-of-folate-receptor-positive-tumors
#2
Qingshou Chen, Xiangjun Meng, Paul McQuade, Daniel Rubins, Shu-An Lin, Zhizhen Zeng, Hyking Haley, Patricia Miller, Dinko Gonzalez Trotter, Philip S Low
The folate receptor (FR) has been established as a promising target for imaging and therapy of cancer (FR-α), inflammation, and autoimmune diseases (FR-β). Several folate-based PET radiotracers have been reported in the literature, but an 18F- labeled folate-PET imaging agent with optimal properties for clinical translation is still lacking. In the present study, we report the design and preclinical evaluation of folate-PEG12-NOTA-Al18F (1), a new folate-PET agent with improved potential for clinical applications...
October 13, 2017: Molecular Pharmaceutics
https://www.readbyqxmd.com/read/29027603/review-of-people-with-retinal-vasculitis-and-positive-quantiferon-%C3%A2-tb-gold-test-in-an-area-nonendemic-for-tuberculosis
#3
David R Brunner, Sandrine A Zweifel, Daniel Barthelmes, Fabio Meier, Christian Böni
PURPOSE: To assess the frequency of a positive QuantiFERON(®)-TB Gold test (quantiferon) among patients with retinal vasculitis in an area nonendemic for tuberculosis (TB); to review clinical characteristics and management of affected individuals. METHODS: Consecutive patients with retinal vasculitis and a positive quantiferon were retrospectively analyzed. Demographics, clinical data, laboratory, imaging findings, and therapy were evaluated. RESULTS: Among 49 patients with retinal vasculitis, 12 (24%) had a positive quantiferon...
October 13, 2017: International Ophthalmology
https://www.readbyqxmd.com/read/29027497/comparative-evaluation-of-treatment-patterns-and-healthcare-utilization-of-newly-diagnosed-rheumatoid-arthritis-patients-by-anti-cyclic-citrullinated-peptide-antibody-status
#4
Lois Lamerato, Kylie Matthews, Kwanza Price, Alan Szymialis, Michael Eaddy, Augustina Ogbonnaya, Huai-Che Shih, Harris Ahmad
BACKGROUND: Anti-cyclic citrullinated peptide (CCP) antibody positivity is an established diagnostic factor for severe disease activity and joint damage and a prognostic factor for aggressive disease in rheumatoid arthritis (RA). OBJECTIVE: To compare RA-related treatment, healthcare utilization, and joint erosion between anti-CCP-positive and anti-CCP-negative RA patients. METHODS: Newly diagnosed RA patients were identified from the Henry Ford Health System database between 1/1/2009 and 12/31/2014; the date of the first RA diagnosis within the study period was the index date...
October 13, 2017: Journal of Medical Economics
https://www.readbyqxmd.com/read/29025545/constrictive-pericarditis
#5
REVIEW
Terrence D Welch, Jae K Oh
Constrictive pericarditis is a potentially treatable cause of diastolic heart failure that arises because a diseased, inelastic pericardium restricts ventricular diastolic expansion. Affected patients present with heart failure with predominant right-sided symptoms and signs. The key to diagnosis is identification of the unique hemodynamic properties associated with constriction: dissociation of intrathoracic and intracardiac pressures and enhanced ventricular interaction. Comprehensive echocardiography with Doppler imaging is useful, but invasive hemodynamic assessment and cross-sectional imaging may be required for confirmation...
November 2017: Cardiology Clinics
https://www.readbyqxmd.com/read/29025422/readout-segmented-multi-shot-diffusion-weighted-mri-of-the-knee-joint-in-patients-with-juvenile-idiopathic-arthritis
#6
Alexander Sauer, Mengxia Li, Annette Holl-Wieden, Thomas Pabst, Henning Neubauer
BACKGROUND: Diffusion-weighted MRI has been proposed as a new technique for imaging synovitis without intravenous contrast application. We investigated diagnostic utility of multi-shot readout-segmented diffusion-weighted MRI (multi-shot DWI) for synovial imaging of the knee joint in patients with juvenile idiopathic arthritis (JIA). METHODS: Thirty-two consecutive patients with confirmed or suspected JIA (21 girls, median age 13 years) underwent routine 1.5 T MRI with contrast-enhanced T1w imaging (contrast-enhanced MRI) and with multi-shot DWI (RESOLVE, b-values 0-50 and 800 s/mm(2))...
October 12, 2017: Pediatric Rheumatology Online Journal
https://www.readbyqxmd.com/read/29024421/generalized-estimating-equation-model-to-compare-drug-effects-on-synovitis-of-the-dominant-wrist-in-severe-rheumatoid-arthritis-between-tocilizumab-versus-adalimumab-versus-abatacept-using-high-resolution-ultrasound
#7
Ying-Chou Chen, Wen-Chan Chiu, Fu-Mei Su, Jia-Feng Chen
PURPOSE: The use of biological agents has revolutionized the treatment of rheumatoid arthritis (RA). However, details of serial synovial changes in imaging evaluation are unclear. Using power Doppler (PD) ultrasound, this study aimed to evaluate the comparative efficacy of biologicals for patients with refractory RA, with the hope that these findings could aid in clinical decision making. METHODS: Patients with RA who received abatacept, adalimumab or tocilizumab therapy were enrolled...
October 12, 2017: International Journal of Rheumatic Diseases
https://www.readbyqxmd.com/read/29023881/review-article-the-role-of-the-microcirculation-in-liver-cirrhosis
#8
REVIEW
T Davies, S Wythe, J O'Beirne, D Martin, E Gilbert-Kawai
BACKGROUND: Intrahepatic microvascular derangements and microcirculatory dysfunction are key in the development of liver cirrhosis and its associated complications. While much has been documented relating to cirrhosis and the dysfunction of the microcirculation in the liver parenchyma, far less is known about the state of the extrahepatic microcirculation and the role this may have in the pathogenesis of multiple organ failure in end stage liver cirrhosis. AIM: To provide an update on the role of the microcirculation in the pathophysiology of cirrhosis and its associated complications and briefly discuss some of the imaging techniques which may be used to directly investigate the microcirculation...
November 2017: Alimentary Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/29023813/dual-catenin-loss-in-murine-liver-causes-tight-junctional-deregulation-and-progressive-intrahepatic-cholestasis
#9
Tirthadipa Pradhan-Sundd, Lili Zhou, Ravi Vats, An Jiang, Laura Molina, Sucha Singh, Minakshi Poddar, Jacquelyn M Russell, Donna B Stolz, Michael Oertel, Udayan Apte, Simon Watkins, Sarangarajan Ranganathan, Kari N Nejak-Bowen, Prithu Sundd, Satdarshan Pal Monga
β-Catenin, the downstream effector of the Wnt signaling, plays important roles in hepatic development, regeneration and tumorigenesis. However, its role at hepatocyte adherens junctions (AJ) is relatively poorly understood, chiefly due to spontaneous compensation by γ-catenin. Here, we simultaneously ablate β- and γ-catenin expression in mouse liver by interbreeding β-catenin-γ-catenin double-floxed mice and albumin-cre transgenic mice. Double knockout mice (DKO) show failure to thrive, impaired hepatocyte differentiation, cholemia, ductular reaction, progressive cholestasis, inflammation, fibrosis and tumorigenesis, which was associated with deregulation of tight junctions (TJ) and bile acid transporters, leading to early morbidity and mortality, a phenotype reminiscent of Progressive Familial Intrahepatic Cholestasis (PFIC)...
October 10, 2017: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/29022101/microflow-imaging-new-doppler-technology-to-detect-low-grade-inflammation-in-patients-with-arthritis
#10
A K P Lim, K Satchithananda, E A Dick, S Abraham, D O Cosgrove
AIM: To assess the efficacy of microvascular imaging in detecting low-grade inflammation in arthritis compared with Power Doppler ultrasound (PDUS). METHOD AND MATERIALS: Patients presenting for ultrasound with arthralgia were assessed with grey-scale, PDUS and Superb Microvascular Imaging (SMI). Videoclips were stored for analysis at a later date. Three musculoskeletal radiologists scored grey-scale changes, signal on PDUS and/or SMI within these joints. If a signal was detected on both PDUS and SMI, the readers graded the conspicuity of vascular signal from the two Doppler techniques using a visual analogue scale...
October 11, 2017: European Radiology
https://www.readbyqxmd.com/read/29021778/the-combined-quantification-and-interpretation-of-multiple-quantitative-magnetic-resonance-imaging-metrics-enlightens-longitudinal-changes-compatible-with-brain-repair-in-relapsing-remitting-multiple-sclerosis-patients
#11
Guillaume Bonnier, Benedicte Maréchal, Mário João Fartaria, Pavel Falkowskiy, José P Marques, Samanta Simioni, Myriam Schluep, Renaud Du Pasquier, Jean-Philippe Thiran, Gunnar Krueger, Cristina Granziera
OBJECTIVE: Quantitative and semi-quantitative MRI (qMRI) metrics provide complementary specificity and differential sensitivity to pathological brain changes compatible with brain inflammation, degeneration, and repair. Moreover, advanced magnetic resonance imaging (MRI) metrics with overlapping elements amplify the true tissue-related information and limit measurement noise. In this work, we combined multiple advanced MRI parameters to assess focal and diffuse brain changes over 2 years in a group of early-stage relapsing-remitting MS patients...
2017: Frontiers in Neurology
https://www.readbyqxmd.com/read/29019759/non-catheter-related-venous-thromboembolism-in-children-imaging-review-from-head-to-toe
#12
Mougnyan Cox, Monica Epelman, Tushar Chandra, Arthur B Meyers, Craig M Johnson, Daniel J Podberesky
Non-catheter-related venous thromboembolism (VTE) is less common in children than in adults. Although the presence of a central venous catheter is the most common cause of venous thrombosis in children, infection and inflammation, malignancy, hypercoagulability, dehydration, and certain sites of normal variant and pathologic anatomic narrowing all predispose to VTE in children. The mortality and morbidity of VTE vary according to the underlying cause, including whether malignancy is present. Various modalities including ultrasonography (US), computed tomography, and magnetic resonance imaging can be used to image VTE, with some modalities better suited to particular parts of the body and clinical scenarios than others...
October 2017: Radiographics: a Review Publication of the Radiological Society of North America, Inc
https://www.readbyqxmd.com/read/29018936/-chameleon-spondylodiscitis-challenge-for-geriatricians
#13
Werner Hofmann
The incidence of spondylodiscitis is increasing and attributable to an aging population with multimorbidities. Spondylodiscitis represents a life-threatening disease. Typical clinical manifestations often involve nonspecific symptoms with back pain; however, due to the frequent absence of fever the disease is often overlooked. Pathogen detection and spinal imaging with magnetic resonance imaging (MRI) are essential for the diagnosis. Identification of the causative pathogen is particularly important for initiating targeted antibiotic treatment...
October 10, 2017: Zeitschrift Für Gerontologie und Geriatrie
https://www.readbyqxmd.com/read/29018908/characterization-of-arthralgia-induced-by-pd-1-antibody-treatment-in-patients-with-metastasized-cutaneous-malignancies
#14
Kristina Buder-Bakhaya, Karolina Benesova, Carsten Schulz, Hoda Anwar, Antonia Dimitrakopoulou-Strauss, Tim F Weber, Alexander Enk, Hanns-Martin Lorenz, Jessica C Hassel
BACKGROUND: PD-1 antibodies (PD1ab) are increasingly used in metastatic melanoma and other malignancies. Arthralgia is an underestimated side effect of PD-1 antibody treatment with unknown cause. Our aim was to characterize PD1ab-induced arthralgia. PATIENTS AND METHODS: We retrospectively included patients with metastatic cutaneous malignancies treated with pembrolizumab or nivolumab ± ipilimumab at the National Center for Tumor Diseases (Heidelberg) between 01/2013 and 09/2016...
October 10, 2017: Cancer Immunology, Immunotherapy: CII
https://www.readbyqxmd.com/read/29017293/endoscopic-therapeutic-approach-for-dysplasia-in-inflammatory-bowel-disease
#15
REVIEW
Sung Noh Hong
Long-standing intestinal inflammation in patients with inflammatory bowel disease (IBD) induces dysplastic change in the intestinal mucosa and increases the risk of subsequent colorectal cancer. The evolving endoscopic techniques and technologies, including dye spraying methods and high-definition images, have been replacing random biopsies and have been revealed as more practical and efficient for detection of dysplasia in IBD patients. In addition, they have potential usefulness in detailed characterization of lesions and in the assessment of endoscopic resectability...
September 2017: Clinical Endoscopy
https://www.readbyqxmd.com/read/29017290/role-of-advanced-endoscopic-imaging-techniques-in-the-management-of-inflammatory-bowel-disease
#16
REVIEW
Eun Soo Kim
Endoscopy plays a crucial role in the management of inflammatory bowel disease (IBD) in terms of diagnosis, monitoring of mucosal status, and surveillance of colitis-associated neoplasia. Mucosal healing evaluated by endoscopy has been recognized as the target of treatment in the era of powerful biologics therapy. The optimal modality for identifying dysplasia in IBD has yet to be well defined. Increasing progress has recently been made in endoscopic technologies to more accurately assess mucosal inflammation and more effectively detect dysplasia...
September 2017: Clinical Endoscopy
https://www.readbyqxmd.com/read/29016379/oxidative-stress-inflammation-and-neuroprogression-in-chronic-ptsd
#17
Mark W Miller, Alex P Lin, Erika J Wolf, Danielle R Miller
Posttraumatic stress disorder is a serious and often disabling syndrome that develops in response to a traumatic event. Many individuals who initially develop the disorder go on to experience a chronic form of the condition that in some cases can last for many years. Among these patients, psychiatric and medical comorbidities are common, including early onset of age-related conditions such as chronic pain, cardiometabolic disease, neurocognitive disorders, and dementia. The hallmark symptoms of posttraumatic stress-recurrent sensory-memory reexperiencing of the trauma(s)-are associated with concomitant activations of threat- and stress-related neurobiological pathways that occur against a tonic backdrop of sleep disturbance and heightened physiological arousal...
October 9, 2017: Harvard Review of Psychiatry
https://www.readbyqxmd.com/read/28991840/granulomatous-upper-gastrointestinal-inflammation-in-pediatric-ulcerative-colitis
#18
Karen Queliza, Faith D Ihekweazu, Deborah Schady, Craig Jensen, Richard Kellermayer
OBJECTIVES: Differentiating ulcerative colitis (UC) and Crohn's disease (CD) can be clinically challenging, especially in children. Granulomatous inflammation has traditionally been attributed to CD. Crypt-associated giant cells and granulomas, however, have been observed in colonic biopsies of UC patients. This phenomenon has not been described in the upper gastrointestinal (UGI) tract with UC. METHODS: Seven pediatric UC patients with granulomatous UGI (gUGI) lesions were identified...
October 6, 2017: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/28991502/sensitivity-of-computed-tomography-for-the-assessment-of-spontaneous-dermoid-cyst-localized-rupture-with-granulomatous-reaction
#19
Alicia Galindo-Ferreiro, Sahar M Elkhamary, Saif Aldossari, Patricia M Akaishi, Hind Alkatan, Rajiv Khandekar, Denny Marcos Garcia, Yerena Muiños-Diaz, Silvana A Schellini, A Augusto V Cruz
PURPOSE: To assess the sensitivity of computed tomography for the diagnosis of spontaneous localized orbital dermoid cyst rupture with granulomatous reaction. METHODS: The charts of 42 patients with dermoid cysts were reviewed retrospectively. The data collected included demographics, clinical features, CT imaging, and postoperative histopathological analysis of the lesions. The association between radiological signs of inflammation and histopathological evidence of an inflammatory reaction was tested by univariate logistic regression...
October 9, 2017: Seminars in Ophthalmology
https://www.readbyqxmd.com/read/28990976/orbital-inflammation-as-a-presenting-sign-for-crest-syndrome
#20
Shirin W Hamed-Azzam, David P D'Cruz, David H Verity
A 61-year-old male was referred with a week's history of a painful and swollen left eye. Examination revealed normal visual acuities, left proptosis and global restriction of ocular ductions, and subretinal fluid at the macula. CT imaging confirmed thickening of the posterior scleral coat, with an associated choroidal effusion. Serology revealed positive antinuclear antibodies with a centromere staining pattern; subsequent rheumatology review revealed extensive telangiectasia with digital ulceration in both hands, and a diagnosis of limited cutaneous systemic sclerosis was made...
September 27, 2017: Ophthalmic Plastic and Reconstructive Surgery
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