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https://www.readbyqxmd.com/read/29148898/enhancement-of-invadopodia-activity-in-glioma-cells-by-sublethal-doses-of-irradiation-and-temozolomide
#1
Leon Mao, Clarissa A Whitehead, Lucia Paradiso, Andrew H Kaye, Andrew P Morokoff, Rodney B Luwor, Stanley S Stylli
OBJECTIVE Glioblastoma is the most common primary central nervous system tumor in adults. These tumors are highly invasive and infiltrative and result in tumor recurrence as well as an extremely poor patient prognosis. The current standard of care involves surgery, radiotherapy, and chemotherapy. However, previous studies have suggested that glioblastoma cells that survive treatment are potentially more invasive. The goal of this study was to investigate whether this increased phenotype in surviving cells is facilitated by actin-rich, membrane-based structures known as invadopodia...
November 17, 2017: Journal of Neurosurgery
https://www.readbyqxmd.com/read/29147435/gliosarcoma-in-young-adults-a-rare-variant-of-glioblastoma
#2
Neha Kakkar, Jaspreet Kaur, Gunjesh Kumar Singh, Pragya Singh, Fouzia Siraj, Ajay Gupta
Gliosarcoma is a rare central nervous system (CNS) malignancy. It is characterized by classical biphasic histological pattern with both glial and sarcomatous components, often seen in fifth and sixth decade of life. They are generally located in the supratentorial region. Due to its rarity, exact treatment recommendations are not available in literature. Since it is considered as a variant of glioblastoma multiforme (GBM), it is treated with surgery followed by adjuvant radiotherapy and temozolomide-based chemotherapy...
April 2017: World Journal of Oncology
https://www.readbyqxmd.com/read/29135107/benefit-and-outcome-of-using-temozolomide-based-chemoradiotherapy-followed-by-temozolomide-alone-for-glioblastoma-in-clinical-practice
#3
Svetlana Salma, Igor Djan, Mladen Bjelan, Petar Vulekovic, Mico Novakovic, Vladimir Vidovic, Milos Lucic
PURPOSE: Temozolomide (TEM), an oral alkylating agent, has shown promising activity in the last 10 years in the treatment of glioblastoma multiforme (GBM). Our goal was to show the benefit of concomitant therapy involving 3D conformal radiotherapy and temozolomide in clinical practice. METHODS: This was a retrospective/prospective study and included a total of 113 patients with GBM diagnosis. Forty- seven patients received postoperative radiotherapy and 66 received concomitant temozolomide plus 3D conformal radiotherapy...
September 2017: Journal of B.U.ON.: Official Journal of the Balkan Union of Oncology
https://www.readbyqxmd.com/read/29135106/evidence-for-the-efficacy-of-disulfiram-and-copper-combination-in-glioblastoma-multiforme-a-propos-of-a-case
#4
Petros N Karamanakos, Dimitrios T Trafalis, Dionysios J Papachristou, Eleftheria S Panteli, Maria Papavasilopoulou, Andreas Karatzas, Dimitrios Kardamakis, Georgios Nasioulas, Marios Marselos
Glioblastoma multiforme (GBM) is the most common and aggressive malignancy of the central nervous system. Treatment usually involves a combination of surgical resection, chemotherapy, and radiotherapy, but ultimately this condition is incurable. Besides the dismal prognosis of GBM, financial factors have also presented challenges for advancing treatments. Taking into consideration the high cost of developing new anticancer drugs as well as the fact that GBM is a rare disease, thus further limiting financial incentive for drug development, it becomes obvious that there has been growing interest for repurposing candidates...
September 2017: Journal of B.U.ON.: Official Journal of the Balkan Union of Oncology
https://www.readbyqxmd.com/read/29126252/monoamines-in-glioblastoma-complex-biology-with-therapeutic-potential
#5
Seamus Patrick Caragher, Robert Raymond Hall, Riasat Ahsan, Atique U Ahmed
Glioblastoma (GBM) is characterized by extremely poor prognoses, despite the use of gross surgical resection, alkylating chemotherapeutic agents, and radiotherapy. Evidence increasingly highlights the role of the tumor microenvironment in enabling this aggressive phenotype. Despite this interest, the role of neurotransmitters, brain-specific messengers underlying synaptic transmission, remains murky. These signaling molecules influence a complex network of molecular pathways and cellular behaviors in many CNS-resident cells including neural stem cells and progenitor cells, neurons, and glia cells...
November 4, 2017: Neuro-oncology
https://www.readbyqxmd.com/read/29125832/minibeam-radiotherapy-with-small-animal-irradiators-in-vitro-and-in-vivo-feasibility-studies
#6
Soha Bazyar, Christina R Inscoe, E Timothy O'Brian, Otto Zhou, Yueh Z Lee
Minibeam radiation therapy (MBRT) delivers an ultrahigh dose of x-ray (⩾100 Gy) in 200-1000 µm beams (peaks), separated by wider non-irradiated regions (valleys) usually as a single temporal fraction. Preclinical studies performed at synchrotron facilities revealed that MBRT is able to ablate tumors while maintaining normal tissue integrity. The main purpose of the present study was to develop an efficient and accessible method to perform MBRT using a conventional x-ray irradiator. We then tested this new method both in vitro and in vivo...
November 10, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/29124650/correction-to-which-elderly-newly-diagnosed-glioblastoma-patients-can-benefit-from-radiotherapy-and-temozolomide-a-perno-prospective-study
#7
Enrico Franceschi, Roberta Depenni, Alexandro Paccapelo, Mario Ermani, Marina Faedi, Carmelo Sturiale, Maria Michiara, Franco Servadei, Giacomo Pavesi, Benedetta Urbini, Anna Pisanello, Girolamo Crisi, Michele A Cavallo, Claudio Dazzi, Claudia Biasini, Federica Bertolini, Claudia Mucciarini, Giuseppe Pasini, Agostino Baruzzi, Alba A Brandes
The members of the PERNO Study Group were not individually captured in the metadata of the original publication. They are included in the metadata of this publication.
November 9, 2017: Journal of Neuro-oncology
https://www.readbyqxmd.com/read/29121274/quality-of-life-in-the-glarius-trial-randomizing-bevacizumab-irinotecan-versus-temozolomide-in-newly-diagnosed-mgmt-nonmethylated-glioblastoma
#8
Niklas Schäfer, Martin Proescholdt, Joachim P Steinbach, Astrid Weyerbrock, Peter Hau, Oliver Grauer, Roland Goldbrunner, Franziska Friedrich, Veit Rohde, Florian Ringel, Uwe Schlegel, Michael Sabel, Michael W Ronellenfitsch, Martin Uhl, Stefan Grau, Mathias Hänel, Oliver Schnell, Dietmar Krex, Peter Vajkoczy, Ghazaleh Tabatabai, Frederic Mack, Christina Schaub, Theophilos Tzaridis, Michael Nießen, Sied Kebir, Barbara Leutgeb, Horst Urbach, Claus Belka, Walter Stummer, Martin Glas, Ulrich Herrlinger
Background: The GLARIUS trial which investigated the efficacy of bevacizumab (BEV)/irinotecan (IRI) as compared to standard temozolomide (TMZ) in the first-line therapy of MGMT-nonmethylated glioblastoma showed that progression-free survival was significantly prolonged by BEV/IRI while overall survival was similar in both arms. The present report focusses on quality of life (QoL) and Karnofsky performance score (KPS) during the whole course of the disease. Patients and methods: Patients (n=170) received standard radiotherapy and were randomized (2:1) for BEV/IRI or standard TMZ...
November 7, 2017: Neuro-oncology
https://www.readbyqxmd.com/read/29113851/impact-of-academic-facility-type-and-volume-on-post-surgical-outcomes-following-diagnosis-of-glioblastoma
#9
Alan Hauser, Sunil W Dutta, Timothy N Showalter, Jason P Sheehan, Surbhi Grover, Daniel M Trifiletti
OBJECTIVE: To identify if facility type and/or facility volume impact overall survival (OS) following diagnosis of glioblastoma (GBM). We also sought to compare early post-surgical outcomes based on these factors. METHODS: The National Cancer Database was queried for patients with GBM diagnosed from 2004 to 2013 with known survival. Patients were grouped based on facility type and facility volume. Multivariable analyses were performed to investigate factors associated OS following diagnosis and Chi-square tests were used to compare early post-surgical outcomes...
November 4, 2017: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/29113349/the-role-of-egfr-double-minutes-in-modulating-the-response-of-malignant-gliomas-to-radiotherapy
#10
Yi-Hong Zhou, Yumay Chen, Yuanjie Hu, Liping Yu, Katherine Tran, Erich Giedzinski, Ning Ru, Alex Gau, Francine Pan, Jiao Qiao, Naomi Atkin, Khang Chi Ly, Nathan Lee, Eric R Siegel, Mark E Linskey, Ping Wang, Charles Limoli
EGFR amplification in cells having double minute chromosomes (DM) is commonly found in glioblastoma multiforme (GBM); however, how much it contributes to the current failure to treat GBM successfully is unknown. We studied two syngeneic primary cultures derived from a GBM with and without cells carrying DM, for their differential molecular and metabolic profiles, in vivo growth patterns, and responses to irradiation (IR). Each cell line has a distinct molecular profile consistent with an invasive "go" (with DM) or angiogenic "grow" phenotype (without DM) demonstrated in vitro and in intracranial xenograft models...
October 6, 2017: Oncotarget
https://www.readbyqxmd.com/read/29107723/results-of-a-policy-of-fast-tapering-of-steroids-after-resection-surgery-in-glioblastoma
#11
Ricardo Díez Valle, Victoria Becerra Castro, Miguel Marigil Sánchez, Jaime Gállego Pérez de Larraya, Jorge M Núñez-Córdoba, Sonia Tejada Solis
BACKGROUND: Corticosteroids are routinely used to treat brain tumors. While steroids have an immediate clinical benefit, their use can lead to a number of relevant complications, and a negative association with overall survival (OS) has been shown in glioblastoma (GBM) patients. There is no evidence in the literature regarding the ideal dose. We assessed the use of steroids in patients with GBM after resection surgery. METHODS: This is a cohort study of 131 newly diagnosed GBM patients that underwent tumor resection surgery...
October 28, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/29106517/tpd52l2-impacts-proliferation-invasiveness-and-apoptosis-of-glioblastoma-cells-via-modulation-of-wnt-%C3%AE-catenin-snail-signaling
#12
Qiang Zhou, Jun-Jie Li, Hai Wang, Hong Li, Bing-Xi Lei, Lei Chen, Wei Xiang, Ya-Wei Liu, Annie Huang, Song-Tao Qi, Yun-Tao Lu
Intratumoral heterogeneity greatly hinders efficiency of target therapy in glioblastoma. To decipher the underlying mechanisms of heterogeneity, patient-derived adult glioblastoma (GBM) cells were separately isolated from margins of T1 gadolinium enhancing tumor lesions (PNCs) and T1 gadolinium enhancing core lesions (ECs). Single clone culture was conducted in ECs and U87MG cell line to screen clones with distinct biological phenotypes. Single cell clones with diverse phenotypes were simultaneously separated from ECs and U87 cell line...
November 2, 2017: Carcinogenesis
https://www.readbyqxmd.com/read/29105282/escitalopram-oxalate-induces-apoptosis-in-u-87mg-cells-and-autophagy-in-gbm8401-cells
#13
Vincent Chin-Hung Chen, Yi-Hsien Hsieh, Li-Jeng Chen, Tsai-Ching Hsu, Bor-Show Tzang
Glioblastoma multiforme (GBM) is recognized as a most aggressive brain cancer with the worst prognosis and survival time. Owing to the anatomic location of gliomas, surgically removing the tumour is very difficult and avoiding damage to vital brain regions during radiotherapy is impossible. Therefore, therapeutic strategies for malignant glioma must urgently be improved. Recent studies have demonstrated that selective serotonin reuptake inhibitors (SSRIs) have cytotoxic effect on certain cancers. Considering as a more superior SSRI, escitalopram oxalate exhibits favourable tolerability and causes generally mild and temporary adverse events...
November 3, 2017: Journal of Cellular and Molecular Medicine
https://www.readbyqxmd.com/read/29105080/glutathione-reductase-mediates-drug-resistance-in-glioblastoma-cells-by-regulating-redox-homeostasis
#14
Zhongling Zhu, Shuangshuang Du, Yibo Du, Jing Ren, Guoguang Ying, Zhao Yan
Glutathione (GSH) and GSH-related enzymes constitute the most important defense system that protects cells from free radical, radiotherapy, and chemotherapy attacks. In this study, we aim to explore the potential role and regulatory mechanism of the GSH redox cycle in drug resistance in glioblastoma multiforme (GBM) cells. We found that temozolomide (TMZ)-resistant glioma cells displayed lower levels of endogenous ROS and higher levels of total antioxidant capacity and GSH than sensitive cells. Moreover, the expression of glutathione reductase (GSR), the key enzyme of the GSH redox cycle, was higher in TMZ-resistant cells than in sensitive cells...
November 3, 2017: Journal of Neurochemistry
https://www.readbyqxmd.com/read/29103769/comparative-assessment-of-three-methods-to-analyze-mgmt-methylation-status-in-a-series-of-350-gliomas-and-gangliogliomas
#15
Leiming Wang, Zhuo Li, Cuicui Liu, Li Chen, Li Liu, Zeliang Hu, Lihong Zhao, Dehong Lu, Lianghong Teng
MGMT promoter methylation is considered as a prognostic and predictive biomarker indicating response to chemotherapy and radiotherapy in glioblastoma. A number of different methods and platforms including pyrosequencing (PSQ), quantitative methylation-specific PCR (qMSP) and immunohistochemistry (IHC), methylation-sensitive high resolution melting (MS-HRM) and NGS (Next Generation Sequencing) have been used to detect MGMT promoter methylation in gliomas. However, controversy remains about the most appropriate method to use for analyzing MGMT status...
October 10, 2017: Pathology, Research and Practice
https://www.readbyqxmd.com/read/29103145/increased-signal-intensity-within-glioblastoma-resection-cavities-on-fluid-attenuated-inversion-recovery-imaging-to-detect-early-progressive-disease-in-patients-receiving-radiotherapy-with-concomitant-temozolomide-therapy
#16
Luke A Perry, Panagiotis Korfiatis, Jay P Agrawal, Bradley J Erickson
PURPOSE: Our study tested the diagnostic accuracy of increased signal intensity (SI) within FLAIR MR images of resection cavities in differentiating early progressive disease (ePD) from pseudoprogression (PsP) in patients with glioblastoma treated with radiotherapy with concomitant temozolomide therapy. METHODS: In this retrospective study approved by our Institutional Review Board, we evaluated the records of 122 consecutive patients with partially or totally resected glioblastoma...
November 4, 2017: Neuroradiology
https://www.readbyqxmd.com/read/29097931/uptake-of-18-f-fet-and-18-f-fch-in-human-glioblastoma-t98g-cell-line-after-irradiation-with-photons-or-carbon-ions
#17
Francesca Pasi, Marco Giovanni Persico, Federica Eleonora Buroni, Carlo Aprile, Marina Hodolic, Franco Corbella, Rosanna Nano, Angelica Facoetti, Lorenzo Lodola
The differential diagnosis between recurrence of gliomas or brain metastases and this phenomenon is important in order to choose the best therapy and predict the prognosis but is still a big problem for physicians. The new emerging MRI, CT, and PET diagnostic modalities still lack sufficient accuracy. Radiolabeled choline and amino acids have been reported to show great tumor specificity. We studied the uptake kinetics of [(18)F]fluoromethyl-choline (FCH) and O-(2-[(18)F]fluoroethyl)-L-tyrosine (FET) by the T98G human glioblastoma cells from 20 to 120 min after irradiation either with photons at 2-10-20 Gy or with carbon ions at 2 Gy (at the National Centre for Oncological Hadrontherapy (CNAO), Pavia, Italy)...
2017: Contrast Media & Molecular Imaging
https://www.readbyqxmd.com/read/29095287/a-comparison-between-oral-chemotherapy-combined-with-radiotherapy-and-radiotherapy-for-newly-diagnosed-glioblastoma-a-systematic-review-and-meta-analysis
#18
REVIEW
Zhuo Wang, Guozi Yang, Yu-Yu Zhang, Yan Yao, Li-Hua Dong
The prognosis of glioblastoma (GBM), a major subtype of grade IV glioma, is rather poor nowadays. The efficiency of chemotherapy serving as the adjunct to radiotherapy (RT) for treating GBM is still controversial. In this study, we aim to investigate the overall survival (OS) and progression-free survival (PFS) in patients with newly diagnosed GBM received RT plus chemotherapy or with RT alone.Literatures were searched from the PubMed, Embase, and Cochrane Library between January 2001 and June 2015. Study selection was conducted based on the following criteria: randomized clinical trial (RCT) of adjuvant RT plus chemotherapy versus RT alone; studies comparing OS and/or PFS; and studies including cases medically confirmed of newly diagnosed GBM...
November 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29090416/addition-of-chemotherapy-to-hypofractionated-radiotherapy-for-glioblastoma-practice-patterns-outcomes-and-predictors-of-survival
#19
Waqar Haque, Vivek Verma, E Brian Butler, Bin S Teh
This study evaluated practice patterns, outcomes, and predictors of survival with respect to the addition of chemotherapy to definitive hypofractionated radiation therapy (HFRT) for glioblastoma in a general patient population. The National Cancer Data Base was queried for patients diagnosed with glioblastoma between 2005 and 2012 that received definitive HFRT with or without chemotherapy. Patient, tumor, and treatment parameters were extracted. Statistics included Kaplan-Meier analysis to evaluate overall survival (OS) as well as Cox proportional hazards modeling to determine variables associated with receipt of chemotherapy and OS...
October 31, 2017: Journal of Neuro-oncology
https://www.readbyqxmd.com/read/29081442/glioblastoma-treatment-in-the-elderly
#20
Masaki Okada, Keisuke Miyake, Takashi Tamiya
Although current treatment advances prolong patient survival, treatment for glioblastoma (GBM) in the elderly has become an emerging issue. The definition of "elderly" differs across articles; GBM predominantly occurs at an age ≥65 years, and the prognosis worsens with increasing age. Regarding molecular markers, isocitrate dehydrogenase (IDH) mutations are less common in the elderly with GBM. Meanwhile, O(6)-methylguanine DNA methyltransferase (MGMT) promoter methylation has been identified in approximately half of patients with GBM...
October 30, 2017: Neurologia Medico-chirurgica
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