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https://www.readbyqxmd.com/read/28640702/diffuse-infiltrating-oligodendroglioma-and-astrocytoma
#1
Martin J van den Bent, Marion Smits, Johan M Kros, Susan M Chang
The new 2016 WHO brain tumor classification defines different diffuse gliomas primarily according to the presence or absence of IDH mutations ( IDH-mt) and combined 1p/19q loss. Today, the diagnosis of anaplastic oligodendroglioma requires the presence of both IDH-mt and 1p/19q co-deletion, whereas anaplastic astrocytoma is divided into IDH wild-type ( IDH-wt) and IDH-mt tumors. IDH-mt tumors have a more favorable prognosis, and tumors with low-grade histology especially tend evolve slowly. IDH-wt tumors are not a homogeneous entity and warrant further molecular testing because some have glioblastoma-like molecular features with poor clinical outcome...
June 22, 2017: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28629376/radiation-therapy-for-older-patients-with-brain-tumors
#2
REVIEW
Giuseppe Minniti, Andrea Riccardo Filippi, Mattia Falchetto Osti, Umberto Ricardi
The incidence of brain tumors in the elderly population has increased over the last few decades. Current treatment includes surgery, radiotherapy and chemotherapy, but the optimal management of older patients with brain tumors remains a matter of debate, since aggressive radiation treatments in this population may be associated with high risks of neurological toxicity and deterioration of quality of life. For such patients, a careful clinical status assessment is mandatory both for clinical decision making and for designing randomized trials to adequately evaluate the optimal combination of radiotherapy and chemotherapy...
June 19, 2017: Radiation Oncology
https://www.readbyqxmd.com/read/28627598/curcumin-exerts-its-tumor-suppressive-function-via-inhibition-of-nedd4-oncoprotein-in-glioma-cancer-cells
#3
Xue Wang, Jiaojiao Deng, Jinxia Yuan, Xin Tang, Yuelong Wang, Haifeng Chen, Yi Liu, Liangxue Zhou
Glioblastoma is the most common brain cancer in adults. It represents one of the top ten malignant tumors with an average survival time of nine months despite treatments with surgery, radiotherapy and chemotherapy. Curcumin is a phytochemical turmeric isolated from root of the Curcuma longa plant. Accumulating evidence have proved that curcumin targets numerous cancer signaling pathways. The E3 ubiquitin ligase NEDD4, neural precursor cell expressed developmentally downregulated protein 4, is frequently overexpressed in various cancers...
June 8, 2017: International Journal of Oncology
https://www.readbyqxmd.com/read/28624789/pediatric-and-adult-glioblastoma-radiosensitization-induced-by-pi3k-mtor-inhibition-causes-early-metabolic-alterations-detected-by-nuclear-magnetic-resonance-spectroscopy
#4
Alice Agliano, Geetha Balarajah, Daniela M Ciobota, Jasmin Sidhu, Paul A Clarke, Chris Jones, Paul Workman, Martin O Leach, Nada M S Al-Saffar
Poor outcome for patients with glioblastomas is often associated with radioresistance. PI3K/mTOR pathway deregulation has been correlated with radioresistance; therefore, PI3K/mTOR inhibition could render tumors radiosensitive. In this study, we show that NVP-BEZ235, a dual PI3K/mTOR inhibitor, potentiates the effects of irradiation in both adult and pediatric glioblastoma cell lines, resulting in early metabolic changes detected by nuclear magnetic resonance (NMR) spectroscopy. NVP-BEZ235 radiosensitises cells to X ray exposure, inducing cell death through the inhibition of CDC25A and the activation of p21cip1(CDKN1A)...
May 24, 2017: Oncotarget
https://www.readbyqxmd.com/read/28621688/radioresistance-of-mesenchymal-glioblastoma-initiating-cells-correlates-with-patient-outcome-and-is-associated-with-activation-of-inflammatory-program
#5
Elisabetta Stanzani, Fina Martínez-Soler, Teresa Martín Mateos, Noemi Vidal, Alberto Villanueva, Miquel Angel Pujana, Jordi Serra-Musach, Núria de la Iglesia, Pepita Giménez-Bonafé, Avelina Tortosa
Glioblastoma (GBM) still remains an incurable disease being radiotherapy (RT) the mainstay treatment. Glioblastoma intra-tumoral heterogeneity and Glioblastoma-Initiating Cells (GICs) challenge the design of effective therapies. We investigated GICs and non-GICs response to RT in a paired in-vitro model and addressed molecular programs activated in GICs after RT. Established GICs heterogeneously expressed several GICs markers and displayed a mesenchymal signature. Upon fractionated RT, GICs reported higher radioresistance compared to non-GICs and showed lower α- and β-values, according to the Linear Quadratic Model interpretation of the survival curves...
June 3, 2017: Oncotarget
https://www.readbyqxmd.com/read/28614736/nanoparticle-mediated-knockdown-of-dna-repair-sensitizes-cells-to-radiotherapy-and-extends-survival-in-a-genetic-mouse-model-of-glioblastoma
#6
Forrest M Kievit, Kui Wang, Tatsuya Ozawa, Aria W Tarudji, John R Silber, Eric C Holland, Richard G Ellenbogen, Miqin Zhang
Glioblastoma (GBM) remains incurable, and recurrent tumors that rarely respond to standard-of-care radiation and chemo-therapies. Therefore, strategies that enhance the effects of these therapies should provide significant benefits to GBM patients. We have developed a nanoparticle delivery vehicle that can stably bind and protect nucleic acids for specific delivery into brain tumor cells. These nanoparticles can deliver therapeutic siRNAs to sensitize GBM cells to radiotherapy and improve GBM treatment via systemic administration...
June 11, 2017: Nanomedicine: Nanotechnology, Biology, and Medicine
https://www.readbyqxmd.com/read/28605463/stereotactic-radiosurgery-and-hypofractionated-radiotherapy-for-glioblastoma
#7
Jennifer L Shah, Gordon Li, Jenny L Shaffer, Melissa I Azoulay, Iris C Gibbs, Seema Nagpal, Scott G Soltys
Glioblastoma is the most common primary brain tumor in adults. Standard therapy depends on patient age and performance status but principally involves surgical resection followed by a 6-wk course of radiation therapy given concurrently with temozolomide chemotherapy. Despite such treatment, prognosis remains poor, with a median survival of 16 mo. Challenges in achieving local control, maintaining quality of life, and limiting toxicity plague treatment strategies for this disease. Radiotherapy dose intensification through hypofractionation and stereotactic radiosurgery is a promising strategy that has been explored to meet these challenges...
June 10, 2017: Neurosurgery
https://www.readbyqxmd.com/read/28602885/high-expression-of-glypican-1-predicts-dissemination-and-poor-prognosis-in-glioblastomas
#8
Taiichi Saito, Kazuhiko Sugiyama, Seiji Hama, Fumiyuki Yamasaki, Takeshi Takayasu, Ryo Nosaka, Shumpei Onishi, Yoshihiro Muragaki, Takakazu Kawamata, Kaoru Kurisu
OBJECTIVE: Glioblastoma (GBM) relapses locally or in a disseminated pattern, and is highly resistant to chemo-radiotherapy. Although dissemination is associated with poor prognosis for GBM patients, the clinico-pathological factors that promote dissemination have not been elucidated. Glypican-1 (GPC-1) is a heparin sulfate proteoglycan that is attached to the extracytoplasmic surface of the cell membrane and regulates cell motility. The aim of this study was to determine whether GPC-1 expression correlated with GBM dissemination and patient prognosis...
June 5, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28602756/antrodia-cinnamomea-sensitizes-radio-chemo-therapy-of-cancer-stem-like-cells-by-modulating-microrna-expression
#9
Yu-Kai Su, Ping-Hsiao Shih, Wei-Hwa Lee, Oluwaseun Adebayo Bamodu, Alexander T H Wu, Chun-Chih Huang, Yew-Min Tzeng, Michael Hsiao, Chi-Tai Yeh, Chien-Min Lin
ETHNOPHARMACOLOGICAL RELEVANCE: The discovery of many tissue-specific cancer stem cells (CSCs) continues to attract scientific attention. These CSCs are considered to be associated with chemo- and radio-resistance, and consequently, failure of conventional anticancer therapies. The recent demonstration of several microRNAs as enhancers of tumorigenicity via modulation of epithelial-mesenchymal transition and cancer stemness, makes them putative novel therapeutic target in oncology. Antrodia cinnamomea is a Chinese traditional medicine with several biological functions including anti-inflammation, antioxidant, and cancer prevention...
June 8, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28599959/photodynamic-process-induced-by-chloro-aluminum-phthalocyanine-nanoemulsion-in-glioblastoma
#10
Andrielle Castilho-Fernandes, Tácila G Lopes, Fernando L Primo, Marcelo R Pinto, Antonio C Tedesco
BACKGROUND: Glioblastoma multiforme (GBM) is a tumor characterized by rapid cell proliferation and migration. GBM constitutes the most aggressive and deadly type of brain tumor and is classified into several subtypes that show high resistance to conventional therapies. There are currently no curative treatments for malignant glioma despite the numerous advances in surgical techniques, radiotherapy, and chemotherapy. Therefore, alternative approaches are required to improve GBM treatment...
June 6, 2017: Photodiagnosis and Photodynamic Therapy
https://www.readbyqxmd.com/read/28598356/nf-%C3%AE%C2%BAb-signalling-in-glioblastoma
#11
REVIEW
Vincent Soubannier, Stefano Stifani
Nuclear factor-κB (NF-κB) is a transcription factor regulating a wide array of genes mediating numerous cellular processes such as proliferation, differentiation, motility and survival, to name a few. Aberrant activation of NF-κB is a frequent event in numerous cancers, including glioblastoma, the most common and lethal form of brain tumours of glial cell origin (collectively termed gliomas). Glioblastoma is characterized by high cellular heterogeneity, resistance to therapy and almost inevitable recurrence after surgery and treatment...
June 9, 2017: Biomedicines
https://www.readbyqxmd.com/read/28592117/mechanisms-regulating-radiosensitivity-of-glioma-stem-cells
#12
Y Liu, Y Shen, T Sun, W Yang
Malignant glioblastoma (GBM) has become a very common and difficult brain tumor given its low cure rate and high recurrence rate. GBMs are resistant to treatments because glioma stem cells (GSCs)/glioma-initiating cells (GICs), a specific subpopulation of GBM, possess properties of tumor stem cells, such as unlimited proficiency, self-renewal, differentiation and resistance to chemotherapy and radiotherapy, and exhibit a very strong DNA repair capability. Radiotherapy has become a preponderant treatment, and researchers have found many significant tumor microenvironmental factors and valuable signaling pathways regulating the GSC radioresistance, including NOTCH, Wnt/β-catenin, Hedgehog, STAT3, and PI3K/AKT/mTOR...
June 8, 2017: Neoplasma
https://www.readbyqxmd.com/read/28574607/prognostic-value-of-mgmt-protein-expression-in-glioblastoma-excluding-non-tumour-cells-from-the-analysis
#13
Rikke H Dahlrot, Joseph Dowsett, Sigurd Fosmark, Annika Malmström, Roger Henriksson, Henning Boldt, Karin de Stricker, Mia D Sørensen, Hans S Poulsen, Malgorzata Lysiak, Peter Söderkvist, Johan Rosell, Steinbjørn Hansen, Bjarne W Kristensen
AIMS: It is important to predict response to treatment with temozolomide (TMZ) in glioblastoma (GBM) patients. Both MGMT protein expression and MGMT promoter methylation have been reported to predict the response to TMZ. We investigated the prognostic value of quantified MGMT protein levels in tumour cells and the prognostic importance of combining information of MGMT protein level and MGMT promoter methylations status. METHODS: MGMT protein expression was quantified in tumour cells in 171 GBMs from the population-based Region of Southern Denmark (RSD)-cohort using a double immunofluorescence approach...
June 2, 2017: Neuropathology and Applied Neurobiology
https://www.readbyqxmd.com/read/28567859/therapeutic-targeting-of-chemoresistant-and-recurrent-glioblastoma-stem-cells-with-a-proapoptotic-variant-of-oncolytic-herpes-simplex-virus
#14
Nusrat Jahan, Jae M Lee, Khalid Shah, Hiroaki Wakimoto
Temozolomide (TMZ) chemotherapy, in combination with maximal safe resection and radiotherapy, is the current standard of care for patients with glioblastoma (GBM). Despite this multimodal approach, GBM inevitably relapses primarily due to resistance to chemo-radiotherapy, and effective treatment is not available for recurrent disease. In this study we identified TMZ resistant patient-derived primary and previously treated recurrent GBM stem cells (GSC), and investigated the therapeutic activity of a pro-apoptotic variant of oHSV (oHSV-TRAIL) in vitro and in vivo...
May 31, 2017: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/28567589/early-tumor-growth-between-initial-resection-and-radiotherapy-of-glioblastoma-incidence-and-impact-on-clinical-outcomes
#15
Javier E Villanueva-Meyer, Seunggu J Han, Soonmee Cha, Nicholas A Butowski
Early tumor growth, or increased contrast-enhancing tumor not related to evolving post-surgical injury, in the interval between surgical resection and initiation of radiotherapy has implications for treatment planning and clinical outcomes. In this study we evaluated the incidence of early tumor growth, correlated tumor growth with survival outcome measures, and assessed predictors of early tumor growth in glioblastoma. We reviewed the records of patients with newly-diagnosed glioblastoma who underwent surgical resection and chemoradiotherapy at our institution...
May 31, 2017: Journal of Neuro-oncology
https://www.readbyqxmd.com/read/28566172/pattern-of-care-and-outcome-in-elderly-patients-with-glioblastoma-data-in-151-patients-from-3-lombardia-hospitals
#16
Andrea Rigamonti, Francesca Imbesi, Antonio Silvani, Gianluca Grimod, Valentina Prone, Paola Gaviani, Antonio Ardizzoia, Ida Milanesi, Virginia Arienti, Elio Agostoni, Francesco Di Meco, Andrea Salmaggi
The appropriate treatment approach for elderly patients with glioblastoma multiforme (GBM) is unclear, although different studies suggest survival benefit in fit patients treated with radiotherapy and chemiotherapy after surgery. We performed a retrospective analysis of 151 patients older than 65years with GBM treated in 3 Lombardia Hospitals. In univariate regression analysis higher KPS (p=0.02), macroscopical total resection (p<0.003), radiotherapy (p<0.0001), chemotherapy (p<0.0001) and second line chemotheraphy (p=0...
July 15, 2017: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/28564669/recent-advances-in-the-treatment-of-gliomas-comprehensive-brain-tumor-center
#17
Steven A Toms, Nikolaos Tapinos
Gliomas are a class of primary brain tumors arising from the supporting structures of the brain, the astrocytes and oligodendrocytes, which range from benign lesions to its most malignant form, the glioblastoma. Treatment for these lesions includes maximal surgical resection, radiotherapy, and chemotherapy. Recently, novel therapies such as immune modulatory therapies and electrical field treatment of the most malignant form, the glioblastoma, have shown promise in improving survival. We will review recent advances in clinical trials, explore the role of multimodal care in brain tumor therapy, as well as explore advances in molecular biology and nanotechnology which offer new hope for treatment of this class of disease...
June 1, 2017: Rhode Island Medical Journal
https://www.readbyqxmd.com/read/28562337/il13ra2-targeted-alpha-particle-therapy-against-glioblastomas
#18
Anirudh Sattiraju, Kiran Kumar Solingapuram Sai, Ang Xuan, Darpan N Pandya, Frankis G Almaguel, Thaddeus J Wadas, Denise M Herpai, Waldemar Debinski, Akiva Mintz
Glioblastoma (GBM) is the most aggressive primary malignant brain cancer that invariably results in a dismal prognosis. Chemotherapy and radiotherapy have not been completely effective as standard treatment options for patients due to recurrent disease. We and others have therefore developed molecular strategies to specifically target interleukin 13 receptor alpha 2 (IL13RA2), a GBM restricted receptor expressed abundantly on over 75% of GBM patients. In this work, we evaluated the potential of Pep-1L, a novel IL13RA2 targeted peptide, as a platform to deliver targeted lethal therapies to GBM...
May 11, 2017: Oncotarget
https://www.readbyqxmd.com/read/28560660/impact-of-treatment-on-survival-of-patients-with-secondary-glioblastoma
#19
Christina Hamisch, Maximilian Ruge, Stephanie Kellermann, Ann-Cathrin Kohl, Inga Duval, Roland Goldbrunner, Stefan J Grau
Data concerning treatment of secondary glioblastoma evolving from previously treated WHO II or III grade tumors are very scarce. The aim of this study was to evaluate the impact of surgical resection and adjuvant treatment on survival in patients with secondary glioblastoma. Thirty-nine patients with secondary glioblastoma evolving from previously treated lower grade gliomas between 2004 and 2015 were included. We evaluated the extent of resection, pathological parameters, adjuvant treatment, as well as survival after malignant transformation...
May 30, 2017: Journal of Neuro-oncology
https://www.readbyqxmd.com/read/28560382/revealing-radiotherapy-and-chemoradiation-induced-pathway-dynamics-in-glioblastoma-by-analyzing-multiple-differential-networks
#20
Jia Zhou, Chao Chen, Hua-Feng Li, Yu-Jie Hu, Hong-Ling Xie
The progression of glioblastoma (GBM) is driven by dynamic alterations in the activity and connectivity of gene pathways. Revealing these dynamic events is necessary in order to understand the pathological mechanisms of, and develop effective treatments for, GBM. The present study aimed to investigate dynamic alterations in pathway activity and connectivity across radiotherapy and chemoradiation conditions in GBM, and to give system‑level insights into molecular mechanisms for GBM therapy. A total of two differential co‑expression networks (DCNs) were constructed using Pearson correlation coefficient analysis and one sided t‑tests, based on gene expression profiles and protein‑protein interaction networks, one for each condition...
July 2017: Molecular Medicine Reports
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