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Stephan Jan Bachmann, Jurij Kotar, Lucia Parolini, Anđela Šarić, Pietro Cicuta, Lorenzo Di Michele, Bortolo Matteo Mognetti
We study phase behaviour of lipid-bilayer vesicles functionalised by ligand-receptor complexes made of synthetic DNA by introducing a modelling framework and a dedicated experimental platform. In particular, we perform Monte Carlo simulations that combine a coarse grained description of the lipid bilayer with state of art analytical models for multivalent ligand-receptor interactions. Using density of state calculations, we derive the partition function in pairs of vesicles and compute the number of ligand-receptor bonds as a function of temperature...
September 20, 2016: Soft Matter
Casper van der Wel, Afshin Vahid, Anđela Šarić, Timon Idema, Doris Heinrich, Daniela J Kraft
The interplay of membrane proteins is vital for many biological processes, such as cellular transport, cell division, and signal transduction between nerve cells. Theoretical considerations have led to the idea that the membrane itself mediates protein self-organization in these processes through minimization of membrane curvature energy. Here, we present a combined experimental and numerical study in which we quantify these interactions directly for the first time. In our experimental model system we control the deformation of a lipid membrane by adhering colloidal particles...
2016: Scientific Reports
Suzana Saric, Raja K Sivamani
Polyphenols are antioxidant molecules found in many foods such as green tea, chocolate, grape seeds, and wine. Polyphenols have antioxidant, anti-inflammatory, and antineoplastic properties. Growing evidence suggests that polyphenols may be used for the prevention of sunburns as polyphenols decrease the damaging effects of ultraviolet A (UVA) and ultraviolet B (UVB) radiation on the skin. This review was conducted to examine the evidence for use of topically and orally ingested polyphenols in prevention of sunburns...
2016: International Journal of Molecular Sciences
Sathish Chikkabyrappa, Doff B McElhinney, Muhamed Saric
We report a rare case of progressive left ventricular outflow tract (LVOT) obstruction after percutaneous device closure of a mechanical prosthetic mitral valve (MV) paravalvular leak (PVL) in the region of aortomitral curtain in a patient who also had small mechanical aortic valve prosthesis with patient-prosthesis mismatch.
August 30, 2016: Echocardiography
Marina Nikitović, Danica Grujičić, Milica Skender Gazibara, Dragana Stanić, Jelena Bokun, Milan Sarić
Primary spinal cord germinomas are an extremely rare group of tumors, most commonly reported as single cases in young Japanese adults. They usually present as intramedullary lesions located in the thoracic and thoracolumbar spine. The importance of preoperative diagnosis lies in the fact that by using radiotherapy and chemotherapy, even without surgery, a good cure rate can be achieved in patients with spinal cord germinoma. However, these tumors demonstrate unspecific imaging characteristics and only some secrete tumor markers...
August 20, 2016: World Neurosurgery
Judita Grzunov Letinić, Marijana Matek Sarić, Martina Piasek, Jasna Jurasović, Veda Marija Varnai, Antonija Sulimanec Grgec, Tatjana Orct
Pregnant and lactating women and infants are vulnerable population groups for adverse effects of toxic metals due to their high nutritional needs and the resultant increased gastrointestinal absorption of both, essential and toxic elements. Although breastfeeding is recommended for infants worldwide, as human milk is the best source of nutrients and other required bioactive factors, it is also a pathway of maternal excretion of toxic substances including toxic metals and thus a source of infant exposure. The aim of this research was to assess health risks in breastfeeding women in the coastal area of the Republic of Croatia and their infants (N=107) due to maternal exposure to Cd and Pb via cigarette smoking, and Hg via seafood and dental amalgam fillings, and their interaction with essential elements...
December 2016: Journal of Trace Elements in Medicine and Biology
Sophie Richard, Ana Saric, Marianne Boucher, Christian Slomianny, Françoise Geffroy, Sébastien Mériaux, Yoann Lalatonne, Patrice X Petit, Laurence Motte
Gliomas are the most common primary brain tumor in humans. To date, the only treatment of care consists of surgical removal of the tumor bulk, irradiation, and chemotherapy, finally resulting in a very poor prognosis due to the lack of efficiency in diagnostics. In this context, nanomedicine combining both diagnostic and magnetic resonance imaging (MRI) and therapeutic applications is a relevant strategy referred to theranostic. Magnetic nanoparticles (NP) are excellent MRI contrast agents because of their large magnetic moment, which induces high transverse relaxivity (r2) characteristic and increased susceptibility effect (T2*)...
October 21, 2016: ACS Chemical Biology
Gabriel Peinkofer, Karsten Burkert, Katja Urban, Benjamin Krausgrill, Jürgen Hescheler, Tomo Saric, Marcel Halbach
Cardiomyocytes (CMs) derived from induced pluripotent stem cells (iPS-CMs) are promising candidates for cell therapy, drug screening, and developmental studies. It is known that iPS-CMs possess immature electrophysiological properties, but an exact characterization of their developmental stage and subtype differentiation is hampered by a lack of knowledge of electrophysiological properties of native CMs from different developmental stages and origins within the heart. Thus, we sought to systematically investigate action potential (AP) properties of native murine CMs and to establish a database that allows classification of stem cell-derived CMs...
October 1, 2016: Stem Cells and Development
Aeshita Dwivedi, Alan Vainrib, Muhamed Saric
PURPOSE OF REVIEW: Functional mitral regurgitation (FMR) is a common complication of left ventricular dysfunction. It is now recognized as an important clinical entity and an independent predictor of poor prognosis in cardiomyopathy patients. In this review, we provide a comprehensive summary of the pathophysiology, latest imaging modalities, and diagnostic criteria for FMR. Additionally, we discuss the recent literature on the continuously evolving surgical and percutaneous treatment options...
September 2016: Current Opinion in Cardiology
Dario Rahelić, Velimir Altabas, Miro Bakula, Stjepan Balić, Ines Balint, Biserka Bergman Marković, Nenad Bicanić, Igor Bjelinski, Velimir Bozikov, Silvija Canecki Varzić, Nikica Car, Maja Cigrovski Berković, Zeljka Crncevic Orlić, Marin Deskin, Ema Drvodelić Sunić, Nives Gojo Tomić, Vesna Goldoni, Marina Gradiser, Davorka Herman Mahecić, Marica Jandrić Balen, Dubravka Jurisić Erzen, Sanja Klobucar Majanović, Slaven Kokić', Mladen Krnic, Ivan Kruljac, Ana-Marija Liberati-Cizmek, Luksić Martina, Zeljko Metelko, Gorana Mirosević, Sanja Mlinaric Vrbica, Ivana Pavlić Renar, Dragomir Petric, Manja Prasek, Ivana Prpić-Kizevać, Maja Radman, Dragan Soldo, Tereza Sarić, Sandi Tesanović, Tina Ticinovic Kurir, Tamara Turk Wensveen, Marija Botica, Milan Vrkljan, Vanja Zjacić Rotkvic, Cedomir Zorić, Zeljko Krznarić
INTRODUCTION: The Croatian Association for Diabetes and Metabolic Disorders of the Croatian Medical Association has issued in 2011 the first national guidelines for the nutrition, education, self-control, and pharmacotherapy of diabetes type 2. According to the increased number of available medicines and new evidence related to the effectiveness and safety of medicines already involved in the therapy there was a need for update of the existing guidelines for the pharmacotherapy of type 2 diabetes in the Republic of Croatia...
January 2016: Lijec̆nic̆ki Vjesnik
Zorana Vasiljevic-Pokrajcic, Natasa Mickovski, Goran Davidovic, Milika Asanin, Branislav Stefanovic, Gordana Krljanac, Mina Radosavljevic-Radovanovic, Nebojsa Radovanovic, Ratko Lasica, Sladjan Milanović, Jovana Bjekić, Marta Majstorovic-Stakic, Danijela Trifunovic, Ana Karadzic, Dubravka Rajic, Aleksandra Milosevic, Marija Zdravkovic, Jelena Saric, Raffaele Bugiardini
BACKGROUND: There is conflicting information about sex differences in presentation, treatment, and outcome after acute coronary syndromes (ACS) in the era of reperfusion therapy and percutaneous coronary intervention. The aim of this study was to examine presentation, acute therapy, and outcomes of men and women with ACS with special emphasis on their relationship with younger age (≤65years). METHODS: From January 2010 to June 2015, we enrolled 5140 patients from 3 primary PCI capable hospitals...
August 2016: International Journal of Cardiology
Matea Perić, Peter Bou Dib, Sven Dennerlein, Marina Musa, Marina Rudan, Anita Lovrić, Andrea Nikolić, Ana Šarić, Sandra Sobočanec, Željka Mačak, Nuno Raimundo, Anita Kriško
In cells living under optimal conditions, protein folding defects are usually prevented by the action of chaperones. Here, we investigate the cell-wide consequences of loss of chaperone function in cytosol, mitochondria or the endoplasmic reticulum (ER) in budding yeast. We find that the decline in chaperone activity in each compartment results in loss of respiration, demonstrating the dependence of mitochondrial activity on cell-wide proteostasis. Furthermore, each chaperone deficiency triggers a response, presumably via the communication among the folding environments of distinct cellular compartments, termed here the cross-organelle stress response (CORE)...
2016: Scientific Reports
Azra Fatima, Dina Ivanyuk, Stefan Herms, Stefanie Heilmann-Heimbach, Orla O'Shea, Charlotte Chapman, Zsuszanna Izsvák, Martin Farr, Jürgen Hescheler, Tomo Šarić
We report here the generation of human iPS cell line UKKi009-A from dermal fibroblasts of a patient carrying heterozygous mutation c.3035-3045delTCCCTCGATGC, p.Leu1012Pro (fs*55) in KCNH2 gene leading to long QT syndrome type 2 (LQT2). We used the Sleeping Beauty transposon-based plasmids expressing OSKM along with microRNAs 307/367 to reprogram the fibroblasts. The iPS cells possess pluripotent stem cell characteristics and differentiate to cell lineages of all three germ layers. This cell line can serve as a source for in vitro modeling of LQT2...
March 2016: Stem Cell Research
P Wirnsberger, D Fijan, A Šarić, M Neumann, C Dellago, D Frenkel
Using non-equilibrium molecular dynamics simulations, it has been recently demonstrated that water molecules align in response to an imposed temperature gradient, resulting in an effective electric field. Here, we investigate how thermally induced fields depend on the underlying treatment of long-ranged interactions. For the short-ranged Wolf method and Ewald summation, we find the peak strength of the field to range between 2 × 10(7) and 5 × 10(7) V/m for a temperature gradient of 5.2 K/Å. Our value for the Wolf method is therefore an order of magnitude lower than the literature value [J...
June 14, 2016: Journal of Chemical Physics
Jelena Šarac, Tena Šarić, Dubravka Havaš Auguštin, Natalija Novokmet, Nenad Vekarić, Mate Mustać, Blaženka Grahovac, Miljenko Kapović, Branimir Nevajda, Anton Glasnović, Saša Missoni, Siiri Rootsi, Pavao Rudan
OBJECTIVES: The research objective of this study is to enlarge and deepen the Y chromosome research on the Croatian population and enable additional insights into the population diversity and historic events that shaped the current genetic landscape of Croatia and Southeastern Europe (SEE). MATERIALS AND METHODS: A high-resolution phylogenetic and phylogeographic analysis of 66 biallelic (SNPs) and 17 microsatellite (STRs) markers of the Y chromosome was performed using 720 Croatian samples...
June 9, 2016: American Journal of Human Biology: the Official Journal of the Human Biology Council
Raquel P F Guiné, Manuela Ferreira, Paula Correia, João Duarte, Marcela Leal, Ivana Rumbak, Irena C Barić, Drazenka Komes, Zvonimir Satalić, Marijana M Sarić, Monica Tarcea, Zita Fazakas, Dijana Jovanoska, Dragoljub Vanevski, Elena Vittadini, Nicoletta Pellegrini, Viktória Szűcs, Júlia Harangozó, Ayman El-Kenawy, Omnia El-Shenawy, Erkan Yalçın, Cem Kösemeci, Dace Klava, Evita Straumite
The objective of this work was to study the degree of knowledge about dietary fibre (DF), as influenced by factors such as gender, level of education, living environment or country. For this, a descriptive cross-sectional study was undertaken on a non-probabilistic sample of 6010 participants from 10 countries in different continents (Europe, Africa and America). The results showed that the participants revealed on average a positive but still low global level of knowledge, which alerts for the need to take some actions to further inform the population about DF and its role as a component of a healthy diet...
September 2016: International Journal of Food Sciences and Nutrition
D Klinčić, S Herceg Romanić, I Brčić Karačonji, M Matek Sarić, J Grzunov Letinić, N Brajenović
This study investigated the levels of 20 congeners of polychlorinated biphenyls (PCBs), including toxic dioxin-like PCBs and 7 organochlorine pesticides (OCPs) in 33 human milk samples collected in 2011 from multiparae living in Zadar, Croatia. Concentrations of ∑PCBs, ∑DDTs, ∑HCHs and HCB in samples ranged from 11.7 to 146.3, 8.7 to 89.2, 0.9 to 28.4, and <LOD to 8.0ngg(-1) milk fat, respectively. PCB congeners -153, -138, -180 and -170 dominated in the PCB profiles, while p,ṕ-DDE was the most abundant OCP...
July 2016: Environmental Toxicology and Pharmacology
Katarina Bojanić, Ruža Grizelj, Daniel Dilber, Dalibor Šarić, Jurica Vuković, Paolo T Pianosi, David J Driscoll, Toby N Weingarten, Ena Pritišanac, Darrell R Schroeder, Juraj Sprung
BACKGROUND: Congenital diaphragmatic hernia (CDH) is associated with lung hypoplasia. CDH survivors may have pulmonary morbidity that can decrease cardiopulmonary exercise. We aimed to examine whether cardiopulmonary exercise testing (CPET) results differ in CDH survivors versus healthy age-matched controls and whether CPET results among CDH survivors differ according to self-reported daily activity. METHODS: In one medical center in Croatia, CDH survivors-patients with surgically corrected CDH who were alive at age 5 years-were invited to participate in spirometry and CPET...
May 26, 2016: Pediatric Pulmonology
Antonia Jelicic Kadic, Mahir Fidahic, Milan Vujcic, Frano Saric, Ivana Propadalo, Ivana Marelja, Svjetlana Dosenovic, Livia Puljak
BACKGROUND: The aim of this study was to analyze whether Cochrane plain language summaries (PLSs) adhere to the Standards for the reporting of Plain Language Summaries in new Cochrane Intervention Reviews (PLEACS). METHODS: A systematic analysis of adherence to the measurable PLEACS items was performed for Cochrane PLSs published from March 2013 to the end of January 2015. Duplicate independent data extraction was performed. An adherence score was calculated for each PLS and for the Cochrane Review Groups (CRGs) that published them...
2016: BMC Medical Research Methodology
V Stankovic, Z Džamic, T Pekmezovic, D K Tepavcevic, M Dozic, M Saric, S Vuckovic, M Nikitovic
AIM: Our aim was to estimate the incidence of acute and late genitourinary toxicity in patients treated with three-dimensional conformal radiotherapy (3DCRT) for localised prostate cancer and to estimate the possible influence of individual and clinical characteristics. MATERIALS AND METHODS: Between September 2009 and September 2013, 225 patients with localised prostate cancer were treated with 3DCRT. Ninety-four patients with an estimated risk of lymph node involvement ≤15%, according to the Roach formula, were evaluated in this study...
September 2016: Clinical Oncology: a Journal of the Royal College of Radiologists
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