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Iva Mucalo, Maja Ortner Hadžiabdić, Tihana Govorčinović, Martina Šarić, Andreia Bruno, Ian Bates
Objective. To adjust and validate the Global Competency Framework (GbCF) to be relevant for Croatian community and hospital pharmacists. Methods. A descriptive study was conducted in three steps: translation, consensus development, and validation by an expert panel and public consultation. Panel members were representatives from community pharmacies, hospital pharmacies, regulatory and professional bodies, academia, and industry. Results. The adapted framework consists of 96 behavioral statements organized in four clusters: Pharmaceutical Public Health, Pharmaceutical Care, Organization and Management, and Personal and Professional Competencies...
October 25, 2016: American Journal of Pharmaceutical Education
Nataša Jokić-Begić, Velimir Altabas, Vesna Antičević, Goran Arbanas, Dražen Begić, Srećko Budi, Miroslav Dumić, Marina Grubić, Jasenka Grujić, Nenad Jakušić, Gordana Stipančić, Davorka Šarić, Iva Žegura
No abstract text is available yet for this article.
November 28, 2016: Archives of Sexual Behavior
Azra Fatima, Guoxing Xu, Filomain Nguemo, Alexey Kuzmenkin, Karsten Burkert, Jürgen Hescheler, Tomo Šarić
We report here a transgenic murine induced pluripotent stem cell (iPSC) line expressing puromycin N-acetyltransferase (PAC) and enhanced green fluorescent protein (EGFP) under the control of α-myosin heavy chain promoter. This transgenic cell line reproducibly differentiates into EGFP-expressing cardiomyocytes (CMs) which can be generated at high purity with puromycin treatment and exhibit molecular and functional properties of immature heart muscle cells. This genetically modified iPSC line can be used for assessment of the utility of CMs for myocardial repair, pharmacological and toxicological applications and development of improved cardiac differentiation protocols...
September 2016: Stem Cell Research
Casper van der Wel, Afshin Vahid, Anđela Šarić, Timon Idema, Doris Heinrich, Daniela J Kraft
No abstract text is available yet for this article.
November 21, 2016: Scientific Reports
Erik Roj Larsen, Kristina Saric
OBJECTIVE: Bipolar disorder in pregnancy may be difficult to treat. The dilemma is whether the women should continue medication throughout pregnancy, and maybe accept a minor risk to harm their unborn child, or discontinue medication and increase the risk of recurrence, which can lead to maternal morbidity, thereby endangering themselves and their foetus. Design and methods In September 2016, three electronic search databases; PubMed, Scopus and PsycInfo, were used searching for clinical trials concerning this question...
November 17, 2016: Acta Neuropsychiatrica
Karin Saric
No abstract text is available yet for this article.
October 2016: Journal of the Medical Library Association: JMLA
Stephan Jan Bachmann, Jurij Kotar, Lucia Parolini, Anđela Šarić, Pietro Cicuta, Lorenzo Di Michele, Bortolo Matteo Mognetti
We study phase behaviour of lipid-bilayer vesicles functionalised by ligand-receptor complexes made of synthetic DNA by introducing a modelling framework and a dedicated experimental platform. In particular, we perform Monte Carlo simulations that combine a coarse grained description of the lipid bilayer with state of art analytical models for multivalent ligand-receptor interactions. Using density of state calculations, we derive the partition function in pairs of vesicles and compute the number of ligand-receptor bonds as a function of temperature...
September 20, 2016: Soft Matter
Casper van der Wel, Afshin Vahid, Anđela Šarić, Timon Idema, Doris Heinrich, Daniela J Kraft
The interplay of membrane proteins is vital for many biological processes, such as cellular transport, cell division, and signal transduction between nerve cells. Theoretical considerations have led to the idea that the membrane itself mediates protein self-organization in these processes through minimization of membrane curvature energy. Here, we present a combined experimental and numerical study in which we quantify these interactions directly for the first time. In our experimental model system we control the deformation of a lipid membrane by adhering colloidal particles...
2016: Scientific Reports
Suzana Saric, Raja K Sivamani
Polyphenols are antioxidant molecules found in many foods such as green tea, chocolate, grape seeds, and wine. Polyphenols have antioxidant, anti-inflammatory, and antineoplastic properties. Growing evidence suggests that polyphenols may be used for the prevention of sunburns as polyphenols decrease the damaging effects of ultraviolet A (UVA) and ultraviolet B (UVB) radiation on the skin. This review was conducted to examine the evidence for use of topically and orally ingested polyphenols in prevention of sunburns...
2016: International Journal of Molecular Sciences
Sathish Chikkabyrappa, Doff B McElhinney, Muhamed Saric
We report a rare case of progressive left ventricular outflow tract (LVOT) obstruction after percutaneous device closure of a mechanical prosthetic mitral valve (MV) paravalvular leak (PVL) in the region of aortomitral curtain in a patient who also had small mechanical aortic valve prosthesis with patient-prosthesis mismatch.
November 2016: Echocardiography
Marina Nikitović, Danica Grujičić, Milica Skender Gazibara, Dragana Stanić, Jelena Bokun, Milan Sarić
Primary spinal cord germinomas are an extremely rare group of tumors, most commonly reported as single cases in young Japanese adults. They usually present as intramedullary lesions located in the thoracic and thoracolumbar spine. The importance of preoperative diagnosis lies in the fact that by using radiotherapy and chemotherapy, even without surgery, a good cure rate can be achieved in patients with spinal cord germinoma. However, these tumors demonstrate unspecific imaging characteristics and only some secrete tumor markers...
August 20, 2016: World Neurosurgery
Judita Grzunov Letinić, Marijana Matek Sarić, Martina Piasek, Jasna Jurasović, Veda Marija Varnai, Antonija Sulimanec Grgec, Tatjana Orct
Pregnant and lactating women and infants are vulnerable population groups for adverse effects of toxic metals due to their high nutritional needs and the resultant increased gastrointestinal absorption of both, essential and toxic elements. Although breastfeeding is recommended for infants worldwide, as human milk is the best source of nutrients and other required bioactive factors, it is also a pathway of maternal excretion of toxic substances including toxic metals and thus a source of infant exposure. The aim of this research was to assess health risks in breastfeeding women in the coastal area of the Republic of Croatia and their infants (N=107) due to maternal exposure to Cd and Pb via cigarette smoking, and Hg via seafood and dental amalgam fillings, and their interaction with essential elements...
December 2016: Journal of Trace Elements in Medicine and Biology
Sophie Richard, Ana Saric, Marianne Boucher, Christian Slomianny, Françoise Geffroy, Sébastien Mériaux, Yoann Lalatonne, Patrice X Petit, Laurence Motte
Gliomas are the most common primary brain tumor in humans. To date, the only treatment of care consists of surgical removal of the tumor bulk, irradiation, and chemotherapy, finally resulting in a very poor prognosis due to the lack of efficiency in diagnostics. In this context, nanomedicine combining both diagnostic and magnetic resonance imaging (MRI) and therapeutic applications is a relevant strategy referred to theranostic. Magnetic nanoparticles (NP) are excellent MRI contrast agents because of their large magnetic moment, which induces high transverse relaxivity (r2) characteristic and increased susceptibility effect (T2*)...
October 21, 2016: ACS Chemical Biology
Gabriel Peinkofer, Karsten Burkert, Katja Urban, Benjamin Krausgrill, Jürgen Hescheler, Tomo Saric, Marcel Halbach
Cardiomyocytes (CMs) derived from induced pluripotent stem cells (iPS-CMs) are promising candidates for cell therapy, drug screening, and developmental studies. It is known that iPS-CMs possess immature electrophysiological properties, but an exact characterization of their developmental stage and subtype differentiation is hampered by a lack of knowledge of electrophysiological properties of native CMs from different developmental stages and origins within the heart. Thus, we sought to systematically investigate action potential (AP) properties of native murine CMs and to establish a database that allows classification of stem cell-derived CMs...
October 1, 2016: Stem Cells and Development
Aeshita Dwivedi, Alan Vainrib, Muhamed Saric
PURPOSE OF REVIEW: Functional mitral regurgitation (FMR) is a common complication of left ventricular dysfunction. It is now recognized as an important clinical entity and an independent predictor of poor prognosis in cardiomyopathy patients. In this review, we provide a comprehensive summary of the pathophysiology, latest imaging modalities, and diagnostic criteria for FMR. Additionally, we discuss the recent literature on the continuously evolving surgical and percutaneous treatment options...
September 2016: Current Opinion in Cardiology
Dario Rahelić, Velimir Altabas, Miro Bakula, Stjepan Balić, Ines Balint, Biserka Bergman Marković, Nenad Bicanić, Igor Bjelinski, Velimir Bozikov, Silvija Canecki Varzić, Nikica Car, Maja Cigrovski Berković, Zeljka Crncevic Orlić, Marin Deskin, Ema Drvodelić Sunić, Nives Gojo Tomić, Vesna Goldoni, Marina Gradiser, Davorka Herman Mahecić, Marica Jandrić Balen, Dubravka Jurisić Erzen, Sanja Klobucar Majanović, Slaven Kokić', Mladen Krnic, Ivan Kruljac, Ana-Marija Liberati-Cizmek, Luksić Martina, Zeljko Metelko, Gorana Mirosević, Sanja Mlinaric Vrbica, Ivana Pavlić Renar, Dragomir Petric, Manja Prasek, Ivana Prpić-Kizevać, Maja Radman, Dragan Soldo, Tereza Sarić, Sandi Tesanović, Tina Ticinovic Kurir, Tamara Turk Wensveen, Marija Botica, Milan Vrkljan, Vanja Zjacić Rotkvic, Cedomir Zorić, Zeljko Krznarić
INTRODUCTION: The Croatian Association for Diabetes and Metabolic Disorders of the Croatian Medical Association has issued in 2011 the first national guidelines for the nutrition, education, self-control, and pharmacotherapy of diabetes type 2. According to the increased number of available medicines and new evidence related to the effectiveness and safety of medicines already involved in the therapy there was a need for update of the existing guidelines for the pharmacotherapy of type 2 diabetes in the Republic of Croatia...
January 2016: Lijec̆nic̆ki Vjesnik
Zorana Vasiljevic-Pokrajcic, Natasa Mickovski, Goran Davidovic, Milika Asanin, Branislav Stefanovic, Gordana Krljanac, Mina Radosavljevic-Radovanovic, Nebojsa Radovanovic, Ratko Lasica, Sladjan Milanović, Jovana Bjekić, Marta Majstorovic-Stakic, Danijela Trifunovic, Ana Karadzic, Dubravka Rajic, Aleksandra Milosevic, Marija Zdravkovic, Jelena Saric, Raffaele Bugiardini
BACKGROUND: There is conflicting information about sex differences in presentation, treatment, and outcome after acute coronary syndromes (ACS) in the era of reperfusion therapy and percutaneous coronary intervention. The aim of this study was to examine presentation, acute therapy, and outcomes of men and women with ACS with special emphasis on their relationship with younger age (≤65years). METHODS: From January 2010 to June 2015, we enrolled 5140 patients from 3 primary PCI capable hospitals...
August 2016: International Journal of Cardiology
Matea Perić, Peter Bou Dib, Sven Dennerlein, Marina Musa, Marina Rudan, Anita Lovrić, Andrea Nikolić, Ana Šarić, Sandra Sobočanec, Željka Mačak, Nuno Raimundo, Anita Kriško
In cells living under optimal conditions, protein folding defects are usually prevented by the action of chaperones. Here, we investigate the cell-wide consequences of loss of chaperone function in cytosol, mitochondria or the endoplasmic reticulum (ER) in budding yeast. We find that the decline in chaperone activity in each compartment results in loss of respiration, demonstrating the dependence of mitochondrial activity on cell-wide proteostasis. Furthermore, each chaperone deficiency triggers a response, presumably via the communication among the folding environments of distinct cellular compartments, termed here the cross-organelle stress response (CORE)...
2016: Scientific Reports
Azra Fatima, Dina Ivanyuk, Stefan Herms, Stefanie Heilmann-Heimbach, Orla O'Shea, Charlotte Chapman, Zsuszanna Izsvák, Martin Farr, Jürgen Hescheler, Tomo Šarić
We report here the generation of human iPS cell line UKKi009-A from dermal fibroblasts of a patient carrying heterozygous mutation c.3035-3045delTCCCTCGATGC, p.Leu1012Pro (fs*55) in KCNH2 gene leading to long QT syndrome type 2 (LQT2). We used the Sleeping Beauty transposon-based plasmids expressing OSKM along with microRNAs 307/367 to reprogram the fibroblasts. The iPS cells possess pluripotent stem cell characteristics and differentiate to cell lineages of all three germ layers. This cell line can serve as a source for in vitro modeling of LQT2...
March 2016: Stem Cell Research
P Wirnsberger, D Fijan, A Šarić, M Neumann, C Dellago, D Frenkel
Using non-equilibrium molecular dynamics simulations, it has been recently demonstrated that water molecules align in response to an imposed temperature gradient, resulting in an effective electric field. Here, we investigate how thermally induced fields depend on the underlying treatment of long-ranged interactions. For the short-ranged Wolf method and Ewald summation, we find the peak strength of the field to range between 2 × 10(7) and 5 × 10(7) V/m for a temperature gradient of 5.2 K/Å. Our value for the Wolf method is therefore an order of magnitude lower than the literature value [J...
June 14, 2016: Journal of Chemical Physics
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