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https://www.readbyqxmd.com/read/29147538/scaling-behaviour-and-rate-determining-steps-in-filamentous-self-assembly
#1
Georg Meisl, Luke Rajah, Samuel A I Cohen, Manuela Pfammatter, Anđela Šarić, Erik Hellstrand, Alexander K Buell, Adriano Aguzzi, Sara Linse, Michele Vendruscolo, Christopher M Dobson, Tuomas P J Knowles
The formation of filaments from naturally occurring protein molecules is a process at the core of a range of functional and aberrant biological phenomena, such as the assembly of the cytoskeleton or the appearance of aggregates in Alzheimer's disease. The macroscopic behaviour associated with such processes is remarkably diverse, ranging from simple nucleated growth to highly cooperative processes with a well-defined lagtime. Thus, conventionally, different molecular mechanisms have been used to explain the self-assembly of different proteins...
October 1, 2017: Chemical Science
https://www.readbyqxmd.com/read/29135093/evaluation-of-safety-of-bevacizumab-as-second-line-treatment-of-patients-with-metastatic-colorectal-cancer
#2
Vladimir Todorovic, Nada Cicmil Saric, Jadranka Lakicevic, Milan Sorat
PURPOSE: Bevacizumab is a relatively new monoclonal antibody introduced in the treatment of metastatic colorectal cancer (CRC). Since varied efficiency and adverse events of this drug were reported, the purpose of this study was to assess the safety of bevacizumab as second-line treatment of patients with metastatic CRC. METHODS: This observational, non-interventional study involved 35 patients with metastatic CRC treated with bevacizumab. Patients were from the Oncology Clinic, Clinical Centre of Montenegro...
September 2017: Journal of B.U.ON.: Official Journal of the Balkan Union of Oncology
https://www.readbyqxmd.com/read/29133340/effects-of-hawthorn-crataegus-pentagyna-leaf-extract-on-electrophysiologic-properties-of-cardiomyocytes-derived-from-human-cardiac-arrhythmia-specific-induced-pluripotent-stem-cells
#3
Sara Pahlavan, Marziyeh Shalchi Tousi, Mahdi Ayyari, Abolfazl Alirezalu, Hassan Ansari, Tomo Saric, Hossein Baharvand
Cardiac arrhythmias are major life-threatening conditions. The landmark discovery of induced pluripotent stem cells has provided a promising in vitro system for modeling hereditary cardiac arrhythmias as well as drug development and toxicity testing. Nowadays, nutraceuticals are frequently used as supplements for cardiovascular therapy. Here we studied the cardiac effects of hawthorn (Crataegus pentagyna) leaf extract using cardiomyocytes (CMs) differentiated from healthy human embryonic stem cells, long QT syndrome type 2 (LQTS2), and catecholaminergic polymorphic ventricular tachycardia type 1 (CPVT1) patient-specific induced pluripotent stem cells...
November 13, 2017: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/29119945/mechanical-force-induces-mitochondrial-fission
#4
Sebastian Carsten Johannes Helle, Qian Feng, Mathias J Aebersold, Luca Hirt, Raphael R Grüter, Afshin Vahid, Andrea Sirianni, Serge Mostowy, Jess G Snedeker, Anđela Šarić, Timon Idema, Tomaso Zambelli, Benoît Kornmann
Eukaryotic cells are densely packed with macromolecular complexes and intertwining organelles, continually transported and reshaped. Intriguingly, organelles avoid clashing and entangling with each other in such limited space. Mitochondria form extensive networks constantly remodeled by fission and fusion. Here, we show that mitochondrial fission is triggered by mechanical forces. Mechano-stimulation of mitochondria - via encounter with motile intracellular pathogens, via external pressure applied by an atomic force microscope, or via cell migration across uneven microsurfaces - results in the recruitment of the mitochondrial fission machinery, and subsequent division...
November 9, 2017: ELife
https://www.readbyqxmd.com/read/29114442/ta2n3-nanocrystals-grown-in-al2o3-thin-layers
#5
Krešimir Salamon, Maja Buljan, Iva Šarić, Mladen Petravić, Sigrid Bernstorff
Tantalum nitride nanoparticles (NPs) and cubic bixbyite-type Ta2N3 nanocrystals (NCs) were grown in (Ta-N+Al2O3)/Al2O3 periodic multilayers (MLs) after thermal treatment. The MLs were prepared by magnetron deposition at room temperature and characterized using grazing incidence small-angle X-ray scattering (GISAXS), X-ray reflectivity (XRR), grazing incidence X-ray diffraction (GIXRD), secondary ion mass spectrometry (SIMS) and X-ray photoelectron spectroscopy (XPS). We found amorphous tantalum nitride NPs at 600-800 °C, with a high degree of ordering along the surface normal and short-range ordering within the layers containing tantalum (metallic layers)...
2017: Beilstein Journal of Nanotechnology
https://www.readbyqxmd.com/read/29109660/the-quality-of-life-in-chronic-patients-in-the-process-of-rehabilitation
#6
Alma Glinac, Lejla Matovic, Edina Saric, Vesna Bratovcic, Selma Sinanovic
Objective: The aim of this study was to examine whether there is a correlation between self-evaluated quality of life, anxiety, depression, motivation, subjective-rated financial status, education, age and autonomous movements in patients with chronic conditions. Respondents and Methods: The study consecutively included 68 chronically ill patients, the average chronological age of 56.21 years. The Hospital Anxiety and Depression Scale for self-evaluation of the quality of life of respondents was used to evaluate the presence of anxiety and depression, the Quality of Life Enjoyment and Satisfaction Questionnaire-Short Form was used for self-evaluation of the quality of life, and the Visual analogue scale of motivation was used for self-evaluation of the level of motivation...
September 2017: Materia Socio-medica
https://www.readbyqxmd.com/read/28891036/acne-scars-how-do-we-grade-them
#7
Ashley K Clark, Suzana Saric, Raja K Sivamani
Acne vulgaris is a chronic inflammatory skin disease that can lead to permanent scarring. Although grading scales exist for acne scarring, there are many limitations, and there is still a need for a well validated gold standard scale for use in clinical practice or research trials. An objective measure of scar severity should be a component of global acne severity evaluations. This manuscript reviews currently available acne scar grading modalities: lesion counting; subjective self-assessment; Acne Scar Rating Scale (ASRS); evaluator-based qualitative and quantitative scarring grading systems; Echelle d'Evaluation Clinique des Cicatrices d'acne (ECCA); Global Scale for Acne Scar Severity (SCAR-S); and imaging...
September 11, 2017: American Journal of Clinical Dermatology
https://www.readbyqxmd.com/read/28857671/effect-of-cuscuta-campestris-parasitism-on-the-physiological-and-anatomical-changes-in-untreated-and-herbicide-treated-sugar-beet
#8
Marija M Saric-Krsmanovic, Dragana M Bozic, Ljiljana M Radivojevic, Jelena S Gajic Umiljendic, Sava P Vrbnicanin
The effects of field dodder on physiological and anatomical processes in untreated sugar beet plants and the effects of propyzamide on field dodder were examined under controlled conditions. The experiment included the following variants: N-noninfested sugar beet plants (control); I - infested sugar beet plants (untreated), and infested plants treated with propyzamide (1500 g a.i. ha(-1) (T1) and 2000 g a.i. ha(-1)(T2)). The following parameters were checked: physiological-pigment contents (chlorophyll a, chlorophyll b, total carotenoids); anatomical -leaf parameters: thickness of epidermis, parenchyma and spongy tissue, mesophyll and underside leaf epidermis, and diameter of bundle sheath cells; petiole parameters: diameter of tracheid, petiole hydraulic conductance, xylem surface, phloem cell diameter and phloem area in sugar beet plants...
November 2, 2017: Journal of Environmental Science and Health. Part. B, Pesticides, Food Contaminants, and Agricultural Wastes
https://www.readbyqxmd.com/read/28840950/3d-transesophageal-echocardiography-and-radiography-of-mitral-valve-prostheses-and-repairs
#9
REVIEW
Nadia Jafar, Michael J Moses, Ricardo J Benenstein, Alan F Vainrib, James N Slater, Henry A Tran, Robert Donnino, Mathew R Williams, Muhamed Saric
This paper provides a comprehensive overview of 3D transesophageal echocardiography still images and movies of mechanical mitral valves, mitral bioprostheses, and mitral valve repairs. Alongside these visual descriptions, the historical overview of surgical and percutaneous mitral valve intervention is described with the special emphasis on the incremental value of 3D transesophageal echocardiography (3DTEE). For each mitral valve intervention, 2D echocardiography, chest x-ray, and fluoroscopy images corresponding to 3DTEE are given...
August 25, 2017: Echocardiography
https://www.readbyqxmd.com/read/28799382/kinetics-of-spontaneous-filament-nucleation-via-oligomers-insights-from-theory-and-simulation
#10
Anđela Šarić, Thomas C T Michaels, Alessio Zaccone, Tuomas P J Knowles, Daan Frenkel
Nucleation processes are at the heart of a large number of phenomena, from cloud formation to protein crystallization. A recently emerging area where nucleation is highly relevant is the initiation of filamentous protein self-assembly, a process that has broad implications in many research areas ranging from medicine to nanotechnology. As such, spontaneous nucleation of protein fibrils has received much attention in recent years with many theoretical and experimental studies focussing on the underlying physical principles...
December 7, 2016: Journal of Chemical Physics
https://www.readbyqxmd.com/read/28735648/knowledge-about-dietary-fibre-and-its-health-benefits-a-cross-sectional-survey-of-2536-residents-from-across-croatia
#11
Marija Ljubicic, Marijana Matek Saric, Ivana Rumbak, Irena Colic Baric, Drazenka Komes, Zvonimir Satalic, Raquel P F Guiné
This cross-sectional study is aimed at identifying the level of understanding of the health benefits of dietary fibre in the prevention of disease, as well as the association between that understanding and fibre consumption in the Croatian population. We believe that nutritional knowledge is important for the consumption of healthy food which includes also a positive reflection on food habits and health. Only well-informed consumers can shop effectively for food rich in dietary fibre and thereby derive the health benefits that fibre can offer...
August 2017: Medical Hypotheses
https://www.readbyqxmd.com/read/28680151/synergistic-cellular-effects-including-mitochondrial-destabilization-autophagy-and-apoptosis-following-low-level-exposure-to-a-mixture-of-lipophilic-persistent-organic-pollutants
#12
Nathan E Rainey, Ana Saric, Alexandre Leberre, Etienne Dewailly, Christian Slomianny, Guillaume Vial, Harold I Zeliger, Patrice X Petit
Humans are exposed to multiple exogenous environmental pollutants. Many of these compounds are parts of mixtures that can exacerbate harmful effects of the individual mixture components. 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), is primarily produced via industrial processes including incineration and the manufacture of herbicides. Both endosulfan and TCDD are persistent organic pollutants which elicit cytotoxic effects by inducing reactive oxygen species generation. Sublethal concentrations of mixtures of TCDD and endosulfan increase oxidative stress, as well as mitochondrial homeostasis disruption, which is preceded by a calcium rise and, in fine, induce cell death...
July 5, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28677712/curvature-variation-controls-particle-aggregation-on-fluid-vesicles
#13
Afshin Vahid, Anđela Šarić, Timon Idema
Cellular membranes exhibit a large variety of shapes, strongly coupled to their function. Many biological processes involve dynamic reshaping of membranes, usually mediated by proteins. This interaction works both ways: while proteins influence the membrane shape, the membrane shape affects the interactions between the proteins. To study these membrane-mediated interactions on closed and anisotropically curved membranes, we use colloids adhered to ellipsoidal membrane vesicles as a model system. We find that two particles on a closed system always attract each other, and tend to align with the direction of largest curvature...
July 19, 2017: Soft Matter
https://www.readbyqxmd.com/read/28665798/consumer-knowledge-and-attitudes-toward-healthy-eating-in-croatia-a-cross-sectional-study
#14
Marija Ljubičić, Marijana Matek Sarić, Irena Colić Barić, Ivana Rumbak, Draženka Komes, Zvonimir Šatalić, Raquel P F Guiné
Unlike fast and restaurant food, diet rich in fibre is known to contribute significantly to health. The aim of our study was to assess eating habits such as consumption of fibre-rich, fast, and restaurant food of the general population in Croatia. For this purpose we used a validated survey designed by the Polytechnic Institute Viseu in Portugal, which includes questions about demographics, good eating habits related to the consumption of the main sources of dietary fibre (fruit, vegetables, and whole grains), and unhealthy eating habits related to the consumption of fast food and restaurant meals...
June 27, 2017: Arhiv za Higijenu Rada i Toksikologiju
https://www.readbyqxmd.com/read/28662092/estimated-collective-effective-dose-to-the-population-from-nuclear-medicine-diagnostic-procedures-in-croatia-a-comparison-of-2010-and-2015
#15
Ivana Kralik, Mario Štefanić, Hrvoje Brkić, Gordan Šarić, Stanko Težak, Svjetlana Grbac Ivanković, Neva Griotto, Damir Štimac, Otmar Rubin, Tamer Salha, Zrinka Ivanišević, Slaven Jurković, Dario Faj
OBJECTIVE: This study presents national surveys of patient exposure from nuclear medicine (NM) diagnostic procedures in 2010 and 2015 in the Republic of Croatia. METHODS: The survey was performed according to the European Commission Dose DataMed (DDM) project methodology. 28 most frequent NM diagnostic procedures were identified. Data about frequencies of procedures and average administered activities of radioisotopes used in those procedures were collected. Average administered activities were converted to effective doses according to the dose conversion coefficients...
2017: PloS One
https://www.readbyqxmd.com/read/28650692/the-role-of-polyphenols-in-rosacea-treatment-a-systematic-review
#16
Suzana Saric, Ashley K Clark, Raja K Sivamani, Peter A Lio, Hadar A Lev-Tov
OBJECTIVES: Various treatment options are available for the management of rosacea symptoms such as facial erythema, telangiectasia, papules and pustules, burning, stinging, and itching. Botanical therapies are commonly used to treat the symptoms. The objective of this review is to evaluate the use of polyphenols in rosacea treatment. DESIGN: PubMed, Embase, Biosis, Web of Knowledge, and Scopus databases were systematically searched for clinical studies evaluating polyphenols in the management of rosacea...
June 26, 2017: Journal of Alternative and Complementary Medicine: Research on Paradigm, Practice, and Policy
https://www.readbyqxmd.com/read/28637842/thromboembolism-in-active-ulcerative-colitis
#17
Ian Y Goh, Stefan Saric, Paul Leschke, Mark McFarlane, Pankaj K Jha
Inflammatory bowel disease (IBD) has a range of both intestinal and extraintestinal manifestations. Thromboembolism involving the arterial and/or venous systems is rare. Early recognition and treatment of thrombosis in patients with IBD may prevent progression and minimise complications. However, clear guidelines on the duration of treatment and indications for primary prophylaxis need to be established. We report a case of a young patient with ulcerative colitis, who developed multiple site arterial and venous thrombosis, all occurring within short intervals of each other...
June 20, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28634768/futile-treatment-a-review
#18
Lenko Šarić, Ivana Prkić, Marko Jukić
The main goal of intensive care medicine is helping patients survive acute threats to their lives, while preserving and restoring life quality. Because of medical advancements, it is now possible to sustain life to an extent that would previously have been difficult to imagine. However, the goals of medicine are not to preserve organ function or physiological activity but to treat and improve the health of a person as a whole. When dealing with medical futilities, physicians and other members of the care team should be aware of some ethical principles...
September 2017: Journal of Bioethical Inquiry
https://www.readbyqxmd.com/read/28613034/torc1-mediated-sensing-of-chaperone-activity-alters-glucose-metabolism-and-extends-lifespan
#19
Matea Perić, Anita Lovrić, Ana Šarić, Marina Musa, Peter Bou Dib, Marina Rudan, Andrea Nikolić, Sandra Sobočanec, Ana-Matea Mikecin, Sven Dennerlein, Ira Milošević, Kristian Vlahoviček, Nuno Raimundo, Anita Kriško
Protein quality control mechanisms, required for normal cellular functioning, encompass multiple functions related to protein production and maintenance. However, the existence of communication between proteostasis and metabolic networks and its underlying mechanisms remain elusive. Here, we report that enhanced chaperone activity and consequent improved proteostasis are sensed by TORC1 via the activity of Hsp82. Chaperone enrichment decreases the level of Hsp82, which deactivates TORC1 and leads to activation of Snf1/AMPK, regardless of glucose availability...
October 2017: Aging Cell
https://www.readbyqxmd.com/read/28575744/decreased-neural-precursor-cell-pool-in-nadph-oxidase-2-deficiency-from-mouse-brain-to-neural-differentiation-of-patient-derived-ipsc
#20
Zeynab Nayernia, Marilena Colaianna, Natalia Robledinos-Antón, Eveline Gutzwiller, Frédérique Sloan-Béna, Elisavet Stathaki, Yousef Hibaoui, Antonio Cuadrado, Jürgen Hescheler, Marie-José Stasia, Tomo Saric, Vincent Jaquet, Karl-Heinz Krause
There is emerging evidence for the involvement of reactive oxygen species (ROS) in the regulation of stem cells and cellular differentiation. Absence of the ROS-generating NADPH oxidase NOX2 in chronic granulomatous disease (CGD) patients, predominantly manifests as immune deficiency, but has also been associated with decreased cognition. Here, we investigate the role of NOX enzymes in neuronal homeostasis in adult mouse brain and in neural cells derived from human induced pluripotent stem cells (iPSC). High levels of NOX2 were found in mouse adult neurogenic regions...
April 24, 2017: Redox Biology
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