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https://www.readbyqxmd.com/read/28735648/knowledge-about-dietary-fibre-and-its-health-benefits-a-cross-sectional-survey-of-2536-residents-from-across-croatia
#1
Marija Ljubicic, Marijana Matek Saric, Ivana Rumbak, Irena Colic Baric, Drazenka Komes, Zvonimir Satalic, Raquel P F Guiné
This cross-sectional study is aimed at identifying the level of understanding of the health benefits of dietary fibre in the prevention of disease, as well as the association between that understanding and fibre consumption in the Croatian population. We believe that nutritional knowledge is important for the consumption of healthy food which includes also a positive reflection on food habits and health. Only well-informed consumers can shop effectively for food rich in dietary fibre and thereby derive the health benefits that fibre can offer...
August 2017: Medical Hypotheses
https://www.readbyqxmd.com/read/28680151/synergistic-cellular-effects-including-mitochondrial-destabilization-autophagy-and-apoptosis-following-low-level-exposure-to-a-mixture-of-lipophilic-persistent-organic-pollutants
#2
Nathan E Rainey, Ana Saric, Alexandre Leberre, Etienne Dewailly, Christian Slomianny, Guillaume Vial, Harold I Zeliger, Patrice X Petit
Humans are exposed to multiple exogenous environmental pollutants. Many of these compounds are parts of mixtures that can exacerbate harmful effects of the individual mixture components. 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), is primarily produced via industrial processes including incineration and the manufacture of herbicides. Both endosulfan and TCDD are persistent organic pollutants which elicit cytotoxic effects by inducing reactive oxygen species generation. Sublethal concentrations of mixtures of TCDD and endosulfan increase oxidative stress, as well as mitochondrial homeostasis disruption, which is preceded by a calcium rise and, in fine, induce cell death...
July 5, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28677712/curvature-variation-controls-particle-aggregation-on-fluid-vesicles
#3
Afshin Vahid, Anđela Šarić, Timon Idema
Cellular membranes exhibit a large variety of shapes, strongly coupled to their function. Many biological processes involve dynamic reshaping of membranes, usually mediated by proteins. This interaction works both ways: while proteins influence the membrane shape, the membrane shape affects the interactions between the proteins. To study these membrane-mediated interactions on closed and anisotropically curved membranes, we use colloids adhered to ellipsoidal membrane vesicles as a model system. We find that two particles on a closed system always attract each other, and tend to align with the direction of largest curvature...
July 19, 2017: Soft Matter
https://www.readbyqxmd.com/read/28665798/consumer-knowledge-and-attitudes-toward-healthy-eating-in-croatia-a-cross-sectional-study
#4
Marija Ljubičić, Marijana Matek Sarić, Irena Colić Barić, Ivana Rumbak, Draženka Komes, Zvonimir Šatalić, Raquel P F Guiné
Unlike fast and restaurant food, diet rich in fibre is known to contribute significantly to health. The aim of our study was to assess eating habits such as consumption of fibre-rich, fast, and restaurant food of the general population in Croatia. For this purpose we used a validated survey designed by the Polytechnic Institute Viseu in Portugal, which includes questions about demographics, good eating habits related to the consumption of the main sources of dietary fibre (fruit, vegetables, and whole grains), and unhealthy eating habits related to the consumption of fast food and restaurant meals...
June 27, 2017: Arhiv za Higijenu Rada i Toksikologiju
https://www.readbyqxmd.com/read/28662092/estimated-collective-effective-dose-to-the-population-from-nuclear-medicine-diagnostic-procedures-in-croatia-a-comparison-of-2010-and-2015
#5
Ivana Kralik, Mario Štefanić, Hrvoje Brkić, Gordan Šarić, Stanko Težak, Svjetlana Grbac Ivanković, Neva Griotto, Damir Štimac, Otmar Rubin, Tamer Salha, Zrinka Ivanišević, Slaven Jurković, Dario Faj
OBJECTIVE: This study presents national surveys of patient exposure from nuclear medicine (NM) diagnostic procedures in 2010 and 2015 in the Republic of Croatia. METHODS: The survey was performed according to the European Commission Dose DataMed (DDM) project methodology. 28 most frequent NM diagnostic procedures were identified. Data about frequencies of procedures and average administered activities of radioisotopes used in those procedures were collected. Average administered activities were converted to effective doses according to the dose conversion coefficients...
2017: PloS One
https://www.readbyqxmd.com/read/28650692/the-role-of-polyphenols-in-rosacea-treatment-a-systematic-review
#6
Suzana Saric, Ashley K Clark, Raja K Sivamani, Peter A Lio, Hadar A Lev-Tov
OBJECTIVES: Various treatment options are available for the management of rosacea symptoms such as facial erythema, telangiectasia, papules and pustules, burning, stinging, and itching. Botanical therapies are commonly used to treat the symptoms. The objective of this review is to evaluate the use of polyphenols in rosacea treatment. DESIGN: PubMed, Embase, Biosis, Web of Knowledge, and Scopus databases were systematically searched for clinical studies evaluating polyphenols in the management of rosacea...
June 26, 2017: Journal of Alternative and Complementary Medicine: Research on Paradigm, Practice, and Policy
https://www.readbyqxmd.com/read/28637842/thromboembolism-in-active-ulcerative-colitis
#7
Ian Y Goh, Stefan Saric, Paul Leschke, Mark McFarlane, Pankaj K Jha
Inflammatory bowel disease (IBD) has a range of both intestinal and extraintestinal manifestations. Thromboembolism involving the arterial and/or venous systems is rare. Early recognition and treatment of thrombosis in patients with IBD may prevent progression and minimise complications. However, clear guidelines on the duration of treatment and indications for primary prophylaxis need to be established. We report a case of a young patient with ulcerative colitis, who developed multiple site arterial and venous thrombosis, all occurring within short intervals of each other...
June 20, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28634768/futile-treatment-a-review
#8
Lenko Šarić, Ivana Prkić, Marko Jukić
The main goal of intensive care medicine is helping patients survive acute threats to their lives, while preserving and restoring life quality. Because of medical advancements, it is now possible to sustain life to an extent that would previously have been difficult to imagine. However, the goals of medicine are not to preserve organ function or physiological activity but to treat and improve the health of a person as a whole. When dealing with medical futilities, physicians and other members of the care team should be aware of some ethical principles...
June 20, 2017: Journal of Bioethical Inquiry
https://www.readbyqxmd.com/read/28613034/torc1-mediated-sensing-of-chaperone-activity-alters-glucose-metabolism-and-extends-lifespan
#9
Matea Perić, Anita Lovrić, Ana Šarić, Marina Musa, Peter Bou Dib, Marina Rudan, Andrea Nikolić, Sandra Sobočanec, Ana-Matea Mikecin, Sven Dennerlein, Ira Milošević, Kristian Vlahoviček, Nuno Raimundo, Anita Kriško
Protein quality control mechanisms, required for normal cellular functioning, encompass multiple functions related to protein production and maintenance. However, the existence of communication between proteostasis and metabolic networks and its underlying mechanisms remain elusive. Here, we report that enhanced chaperone activity and consequent improved proteostasis are sensed by TORC1 via the activity of Hsp82. Chaperone enrichment decreases the level of Hsp82, which deactivates TORC1 and leads to activation of Snf1/AMPK, regardless of glucose availability...
June 14, 2017: Aging Cell
https://www.readbyqxmd.com/read/28575744/decreased-neural-precursor-cell-pool-in-nadph-oxidase-2-deficiency-from-mouse-brain-to-neural-differentiation-of-patient-derived-ipsc
#10
Zeynab Nayernia, Marilena Colaianna, Natalia Robledinos-Antón, Eveline Gutzwiller, Frédérique Sloan-Béna, Elisavet Stathaki, Yousef Hibaoui, Antonio Cuadrado, Jürgen Hescheler, Marie-José Stasia, Tomo Saric, Vincent Jaquet, Karl-Heinz Krause
There is emerging evidence for the involvement of reactive oxygen species (ROS) in the regulation of stem cells and cellular differentiation. Absence of the ROS-generating NADPH oxidase NOX2 in chronic granulomatous disease (CGD) patients, predominantly manifests as immune deficiency, but has also been associated with decreased cognition. Here, we investigate the role of NOX enzymes in neuronal homeostasis in adult mouse brain and in neural cells derived from human induced pluripotent stem cells (iPSC). High levels of NOX2 were found in mouse adult neurogenic regions...
April 24, 2017: Redox Biology
https://www.readbyqxmd.com/read/28540749/aflatoxins-contamination-of-maize-in-serbia-the-impact-of-weather-conditions-in-2015
#11
Elizabet Janić Hajnal, Jovana Kos, Jelena Krulj, Saša Krstović, Igor Jajić, Lato Pezo, Bojana Šarić, Nataša Nedeljković
In recent years climate changes recorded in temperate regions of Europe have led to aflatoxin (AF) contamination of maize. Thus, the aim of this study was to investigate the influence of weather conditions on levels of aflatoxin B1 (AFB1), aflatoxin B2 (AFB2), aflatoxin G1 (AFG1) and aflatoxin G2 (AFG2) in 180 maize samples collected from the main maize-growing regions (Western Bačka, North Banat, South Banat and Central Serbia) in Serbia after harvest in 2015. The concentrations of AFs were determined by a validated HPLC method with post-column derivatisation and fluorescence detection (HPLC-FLD)...
July 11, 2017: Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment
https://www.readbyqxmd.com/read/28448830/biogenesis-of-secondary-mycogenic-minerals-related-to-wall-paintings-deterioration-process
#12
Nikola Unković, Suzana Erić, Kristina Šarić, Miloš Stupar, Željko Savković, Slaviša Stanković, Olja Stanojević, Ivica Dimkić, Jelena Vukojević, Milica Ljaljević Grbić
Present study addresses potential of fungal strains, isolated from deteriorated mural paintings and surrounding air environment of the Church of the Holy Ascension in Veliki Krčimir (Serbia), to precipitate mycogenic minerals, when cultivated on agarized B4 medium. Utilizing culture-based isolation methods, 38 filamentous fungi were obtained in total, 23 from mural paintings and 15 from air, respectively, mainly ascomycetes, while Bjerkandera adusta and Thanatephorus cucumeris were only basidiomycetes. A total of 31 of 38 fungal isolates, more than 80%, were able to form minerals of different morphologies and variable size, determined via SEM-EDS and XRPD, to be either calcite or calcite and weddellite association...
September 2017: Micron: the International Research and Review Journal for Microscopy
https://www.readbyqxmd.com/read/28439003/numerical-evidence-for-thermally-induced-monopoles
#13
Peter Wirnsberger, Domagoj Fijan, Roger A Lightwood, Anđela Šarić, Christoph Dellago, Daan Frenkel
Electric charges are conserved. The same would be expected to hold for magnetic charges, yet magnetic monopoles have never been observed. It is therefore surprising that the laws of nonequilibrium thermodynamics, combined with Maxwell's equations, suggest that colloidal particles heated or cooled in certain polar or paramagnetic solvents may behave as if they carry an electric/magnetic charge. Here, we present numerical simulations that show that the field distribution around a pair of such heated/cooled colloidal particles agrees quantitatively with the theoretical predictions for a pair of oppositely charged electric or magnetic monopoles...
May 9, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28404615/myeloperoxidase-mediates-postischemic-arrhythmogenic-ventricular-remodeling
#14
Martin Mollenhauer, Kai Friedrichs, Max Lange, Jan Gesenberg, Lisa Remane, Christina Kerkenpaß, Jenny Krause, Johanna Schneider, Thorben Ravekes, Martina Maass, Marcel Halbach, Gabriel Peinkofer, Tomo Saric, Dennis Mehrkens, Matti Adam, Florian G Deuschl, Denise Lau, Birgit Geertz, Kashish Manchanda, Thomas Eschenhagen, Lukas Kubala, Tanja K Rudolph, Yuping Wu, W H Wilson Tang, Stanley L Hazen, Stephan Baldus, Anna Klinke, Volker Rudolph
RATIONALE: Ventricular arrhythmias remain the leading cause of death in patients suffering myocardial ischemia. Myeloperoxidase, a heme enzyme released by polymorphonuclear neutrophils, accumulates within ischemic myocardium and has been linked to adverse left ventricular remodeling. OBJECTIVE: To reveal the role of myeloperoxidase for the development of ventricular arrhythmias. METHODS AND RESULTS: In different murine models of myocardial ischemia, myeloperoxidase deficiency profoundly decreased vulnerability for ventricular tachycardia on programmed right ventricular and burst stimulation and spontaneously as assessed by ECG telemetry after isoproterenol injection...
June 23, 2017: Circulation Research
https://www.readbyqxmd.com/read/28394104/socio-cultural-effects-on-mental-health-and-common-chronic-diseases-in-primary-care-patients-in-east-and-west-mostar-bosnia-and-herzegovina-preliminary-results
#15
Ivan Vasilj, Marina Vasilj, Branka Aukst Margetić, Ivo Curić, Belma Sarić, Marko Martinac, Dragan Babić, Milenko Bevanda
Since war activities, the previously mixed population of Mostar, Bosnia and Herzegovina, live in segregated parts of the town based on ethnicity. The aim of this study was to examine differences in health risks and health status between populations of the two parts of the town. Health status of 300 randomly selected primary care patients was evaluated by practicing family physicians in two main primary care centers in West and East Mostar. Each group consisted of 150 patients. Data were collected between December 2013 and May 2014...
June 2016: Acta Clinica Croatica
https://www.readbyqxmd.com/read/28387361/origin-and-spread-of-human-mitochondrial-dna-haplogroup-u7
#16
Hovhannes Sahakyan, Baharak Hooshiar Kashani, Rakesh Tamang, Alena Kushniarevich, Amirtharaj Francis, Marta D Costa, Ajai Kumar Pathak, Zaruhi Khachatryan, Indu Sharma, Mannis van Oven, Jüri Parik, Hrant Hovhannisyan, Ene Metspalu, Erwan Pennarun, Monika Karmin, Erika Tamm, Kristiina Tambets, Ardeshir Bahmanimehr, Tuuli Reisberg, Maere Reidla, Alessandro Achilli, Anna Olivieri, Francesca Gandini, Ugo A Perego, Nadia Al-Zahery, Massoud Houshmand, Mohammad Hossein Sanati, Pedro Soares, Ekta Rai, Jelena Šarac, Tena Šarić, Varun Sharma, Luisa Pereira, Veronica Fernandes, Viktor Černý, Shirin Farjadian, Deepankar Pratap Singh, Hülya Azakli, Duran Üstek, Natalia Ekomasova Trofimova, Ildus Kutuev, Sergei Litvinov, Marina Bermisheva, Elza K Khusnutdinova, Niraj Rai, Manvendra Singh, Vijay Kumar Singh, Alla G Reddy, Helle-Viivi Tolk, Svjetlana Cvjetan, Lovorka Barac Lauc, Pavao Rudan, Emmanuel N Michalodimitrakis, Nicholas P Anagnou, Kalliopi I Pappa, Maria V Golubenko, Vladimir Orekhov, Svetlana A Borinskaya, Katrin Kaldma, Monica A Schauer, Maya Simionescu, Vladislava Gusar, Elena Grechanina, Periyasamy Govindaraj, Mikhail Voevoda, Larissa Damba, Swarkar Sharma, Lalji Singh, Ornella Semino, Doron M Behar, Levon Yepiskoposyan, Martin B Richards, Mait Metspalu, Toomas Kivisild, Kumarasamy Thangaraj, Phillip Endicott, Gyaneshwer Chaubey, Antonio Torroni, Richard Villems
Human mitochondrial DNA haplogroup U is among the initial maternal founders in Southwest Asia and Europe and one that best indicates matrilineal genetic continuity between late Pleistocene hunter-gatherer groups and present-day populations of Europe. While most haplogroup U subclades are older than 30 thousand years, the comparatively recent coalescence time of the extant variation of haplogroup U7 (~16-19 thousand years ago) suggests that its current distribution is the consequence of more recent dispersal events, despite its wide geographical range across Europe, the Near East and South Asia...
April 7, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28384120/dyslipidemia-in-subclinical-hypothyroidism-requires-assessment-of-small-dense-low-density-lipoprotein-cholesterol-sdldl-c
#17
Maida Seferovic Saric, Miljenka-Jelena Jurasic, Slavica Sovic, Bojana Kranjcec, Tatjana Glivetic, Vida Demarin
BACKGROUND: Usually both hypothyroidism and hyperthyroidism are related to the cardiovascular and cerebrovascular disease development. The relationship between subclinical hypothyroidism has been widely investigated but the findings remain controversial. The aim of the present study was to evaluate the lipid profile in patients with subclinical hypothyroidism (SHypo) in comparison to controls and to determine the association of SHypo and dyslipidemia in attempt to find importance of small dense low-density lipoprotein cholesterol (sdLDL-C) in atherosclerosis...
April 6, 2017: Romanian Journal of Internal Medicine, Revue Roumaine de Médecine Interne
https://www.readbyqxmd.com/read/28379826/congruence-of-patient-self-rating-of-health-with-family-physician-ratings
#18
Nancy C Elder, Ryan Imhoff, Jennifer Chubinski, C Jeffrey Jacobson, Harini Pallerla, Petar Saric, Vitaliy Rotenberg, Mary Beth Vonder Meulen, Anthony C Leonard, Mark Carrozza, Saundra Regan
BACKGROUND: A single self-rated health (SRH) question is associated with health outcomes, but agreement between SRH and physician-rated patient health (PRPH) has been poorly studied. We studied patient and physician reasoning for health ratings and the role played by patient lifestyle and objective health measures in the congruence between SRH and PRPH. METHODS: Surveys of established family medicine patients and their physicians, and medical record review at 4 offices...
March 2017: Journal of the American Board of Family Medicine: JABFM
https://www.readbyqxmd.com/read/28334554/rapid-establishment-of-the-european-bank-for-induced-pluripotent-stem-cells-ebisc-the-hot-start-experience
#19
Paul A De Sousa, Rachel Steeg, Elisabeth Wachter, Kevin Bruce, Jason King, Marieke Hoeve, Shalinee Khadun, George McConnachie, Julie Holder, Andreas Kurtz, Stefanie Seltmann, Johannes Dewender, Sascha Reimann, Glyn Stacey, Orla O'Shea, Charlotte Chapman, Lyn Healy, Heiko Zimmermann, Bryan Bolton, Trisha Rawat, Isobel Atkin, Anna Veiga, Bernd Kuebler, Blanca Miranda Serano, Tomo Saric, Jürgen Hescheler, Oliver Brüstle, Michael Peitz, Cornelia Thiele, Niels Geijsen, Bjørn Holst, Christian Clausen, Majlinda Lako, Lyle Armstrong, Shailesh K Gupta, Alexander J Kvist, Ryan Hicks, Anna Jonebring, Gabriella Brolén, Andreas Ebneth, Alfredo Cabrera-Socorro, Patrik Foerch, Martine Geraerts, Tina C Stummann, Shawn Harmon, Carol George, Ian Streeter, Laura Clarke, Helen Parkinson, Peter W Harrison, Adam Faulconbridge, Luca Cherubin, Tony Burdett, Cesar Trigueros, Minal J Patel, Christa Lucas, Barry Hardy, Rok Predan, Joh Dokler, Maja Brajnik, Oliver Keminer, Ole Pless, Philip Gribbon, Carsten Claussen, Annette Ringwald, Beate Kreisel, Aidan Courtney, Timothy E Allsopp
A fast track "Hot Start" process was implemented to launch the European Bank for Induced Pluripotent Stem Cells (EBiSC) to provide early release of a range of established control and disease linked human induced pluripotent stem cell (hiPSC) lines. Established practice amongst consortium members was surveyed to arrive at harmonised and publically accessible Standard Operations Procedures (SOPs) for tissue procurement, bio-sample tracking, iPSC expansion, cryopreservation, qualification and distribution to the research community...
April 2017: Stem Cell Research
https://www.readbyqxmd.com/read/28328544/non-toxic-fluorescent-phosphonium-probes-to-detect-mitochondrial-potential
#20
Ana Šarić, Ivo Crnolatac, Frédéric Bouillaud, Sandra Sobočanec, Ana-Matea Mikecin, Željka Mačak Šafranko, Todor Delgeorgiev, Ivo Piantanida, Tihomir Balog, Patrice X Petit
We evaluated our phosphonium-based fluorescent probes for selective staining of mitochondria. Currently used probes for monitoring mitochondrial membrane potential show varying degrees of interference with cell metabolism, photo-induced damage and probe binding. Here presented probes are characterised by highly efficient cellular uptake and specific accumulation in mitochondria. Fluorescent detection of the probes was accomplished using flow cytometry and confocal microscopy imaging of yeast and mammalian cells...
March 22, 2017: Methods and Applications in Fluorescence
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