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https://www.readbyqxmd.com/read/28944734/outcomes-based-contracting-experience-research-findings-from-u-s-and-european-stakeholders
#1
Tara Nazareth, John J Ko, Rahul Sasane, Christian Frois, Stephen Carpenter, Sebastian Demean, Ashok Vegesna, Eric Wu, Robert P Navarro
BACKGROUND: Outcomes-based contracts (OBCs), a type of risk-sharing arrangement (RSA), have emerged as a promising avenue for payers to engage with pharmaceutical manufacturers to share risk and improve patient access to medicines via evaluation of real-world outcomes. OBJECTIVE: To assess the level of recent OBC activity and stakeholder perceptions of these arrangements, as well as the outlook for future OBC activity from a payer and manufacturer perspective in the United States and EU-5 (France, Germany, Italy, Spain, and the United Kingdom)...
October 2017: Journal of Managed Care & Specialty Pharmacy
https://www.readbyqxmd.com/read/28944728/performance-based-risk-sharing-arrangements-u-s-payer-experience
#2
Joseph A Goble, Brian Ung, Sascha van Boemmel-Wegmann, Robert P Navarro, Andrew Parece
BACKGROUND: As a result of global concern about rising drug costs, many U.S. payers and European agencies such as the National Health Service have partnered with pharmaceutical companies in performance-based risk-sharing arrangements (PBRSAs) by which manufacturers share financial risk with health care purchasing entities and authorities. However, PBRSAs present many administrative and legal challenges that have minimized successful contract experiences in the United States. OBJECTIVE: To (a) identify drug and disease characteristics and contract components that contribute to successful PBRSA experiences and the primary barriers to PBRSA execution and (b) explore solutions to facilitate contract negotiation and execution...
October 2017: Journal of Managed Care & Specialty Pharmacy
https://www.readbyqxmd.com/read/28944726/paying-for-cures-how-can-we-afford-it-managed-care-pharmacy-stakeholder-perceptions-of-policy-options-to-address-affordability-of-prescription-drugs
#3
Kai Yeung, Kangho Suh, Anirban Basu, Louis P Garrison, Aasthaa Bansal, Josh J Carlson
BACKGROUND: High-priced medications with curative potential, such as the newer hepatitis C therapies, have contributed to the recent growth in pharmaceutical expenditure. Despite the obvious benefits, health care decision makers are just beginning to grapple with questions of how to value and pay for curative therapies that may feature large upfront cost, followed by health benefits that are reaped over a patient's lifespan. Alternative policy options have been proposed to promote high value and financially sustainable use of these therapies...
October 2017: Journal of Managed Care & Specialty Pharmacy
https://www.readbyqxmd.com/read/28943977/barriers-to-reporting-of-adverse-drugs-reactions-a-cross-sectional-study-among-community-pharmacists-in-united-kingdom
#4
Ejaz Cheema, Abdul Haseeb, Tahir M Khan, Paul Sutcliffe, Donald R Singer
BACKGROUND: Adverse Drug Reactions (ADRs) are a major public health problem. Prompt reporting of suspected ADRs is fundamental in the post-marketing surveillance of medicines and helps in ensuring medicine safety. However, fewer ADRs are reported in general and in particular by community pharmacists. There is limited knowledge about the factors which are preventing community pharmacists in the UK from reporting an ADR. OBJECTIVES: To identify the barriers to ADR reporting among community pharmacists practicing in the UK...
July 2017: Pharmacy Practice
https://www.readbyqxmd.com/read/28943712/bringing-alcohol-treatment-to-driving-under-the-influence-programs-perceptions-from-first-time-offenders
#5
Karen Chan Osilla, Magdalena Kulesza, Jeanne Miranda
Alcohol use disorders (AUDs) are common among first-time driving under the influence (DUI) offenders. Individuals with a DUI arrest may attend a DUI alcohol education program for license reinstatement. We evaluated the acceptability of cognitive behavioral treatment (CBT) for AUDs adapted for DUI programs. Participants (N=35) were enrolled in one of two DUI programs in Los Angeles and were an average of 34.5 (SD=11.9) years old; 66% male; 37.1% African American, 34.2% Hispanic/Latino(a), and 20% non-Hispanic White...
2017: Alcoholism Treatment Quarterly
https://www.readbyqxmd.com/read/28943670/african-american-girls-ideal-dating-relationship-now-and-in-the-future
#6
Katrina J Debnam, Donna E Howard, Mary A Garza, Kerry M Green
Adolescence is a particularly important and challenging time for developing long lasting romantic relationship patterns. However, limited empirical research has explored teen perceptions of ideal partner characteristics during adolescence or their significance to the quality of current and future relationships. Semi-structured in-depth interviews were conducted with 33 African American high school girls to shed light on the qualities desired in their dating relationships and relational factors that influence teen dating behaviors...
2017: Youth & Society
https://www.readbyqxmd.com/read/28943475/nutrition-labeling-reduces-valuations-of-food-through-multiple-health-and-taste-channels
#7
Geoffrey Fisher
One popularized technique to promote healthy dietary choice involves posting calorie or other nutritional information at the time individuals make a consumption decision. While the evidence on the effectiveness of such interventions is mixed, relatively little work has focused on the underlying mechanisms of how such labels alter behavior. In the research reported here, we asked hungry laboratory subjects to make bids over foods with and without nutrition labels present. We found that the presence of a nutrition label reduced bids by an average of 25 cents...
September 21, 2017: Appetite
https://www.readbyqxmd.com/read/28943091/single-neuron-correlates-of-conscious-perception-in-the-human-medial-temporal-lobe
#8
Thomas P Reber, Jennifer Faber, Johannes Niediek, Jan Boström, Christian E Elger, Florian Mormann
The neuronal mechanisms giving rise to conscious perception remain largely elusive [1]. It is known that the strength of single-neuron activity correlates with conscious perception, especially in anterior regions of the ventral pathway in non-human primates [2-4] and in the human medial temporal lobe (MTL) [5, 6]. It is unclear, however, whether single-neuron correlates of conscious perception are characterized solely by the magnitude of neuronal responses, and whether the correlates of perception are equally prominent across different regions of the human MTL...
September 18, 2017: Current Biology: CB
https://www.readbyqxmd.com/read/28942731/factors-influencing-trainee-doctor-emigration-in-a-high-income-country-a-mixed-methods-study
#9
Nicholas Clarke, Sophie Crowe, Niamh Humphries, Ronan Conroy, Simon O'Hare, Paul Kavanagh, Ruairi Brugha
BACKGROUND: The Global Code of Practice on the International Recruitment of Health Personnel focuses particularly on migration of doctors from low- and middle-income countries. Less is understood about migration from high-income countries. Recession has impacted several European countries in recent years, and in some cases emigration has reached unprecedented levels. This study measures and explores the predictors of trainee doctor emigration from Ireland. METHODS: Using a partially mixed sequential dominant (quantitative) study design, a nationally representative sample of 893 trainee doctors was invited to complete an online survey...
September 25, 2017: Human Resources for Health
https://www.readbyqxmd.com/read/28942494/working-with-the-hmong-population-in-a-genetics-setting-an-interpreter-perspective
#10
Meghan Krieger, Aime Agather, Kathryn Douglass, Catherine A Reiser, Elizabeth M Petty
The aim of this pilot qualitative study was to describe the experiences and beliefs of medical interpreters when working with genetic counselors and other genetic providers caring for Hmong patients who are not native English speakers. Specific goals were to identify interpreters' thoughts and perceptions on (a) their roles during sessions, (b) unique challenges in a genetics session, (c) knowledge genetics providers need when working with Hmong patients and interpreters, and (d) supports and training needed to effectively interpret in a genetics setting...
September 24, 2017: Journal of Genetic Counseling
https://www.readbyqxmd.com/read/28942289/polysubstance-use-by-psychiatry-inpatients-with-co-occurring-mental-health-and-substance-use-disorders
#11
Christine Timko, Mark Ilgen, Marie Haverfield, Alexandra Shelley, Jessica Y Breland
BACKGROUND: Polysubstance use, the consumption of more than one substance over a defined period, is common and associated with psychiatric problems and poor treatment adherence and outcomes. This study examined past-month polysubstance use at intake among psychiatry inpatients with co-occurring mental health and substance use disorders, and outcomes 3 months later. METHODS: Participants (n=406 psychiatry inpatients with documented mental health and substance use disorders) completed a baseline and a 3-month follow-up (84%) interview...
September 15, 2017: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/28942097/facilitating-peer-based-learning-through-summative-assessment-an-adaptation-of-the-objective-structured-clinical-assessment-tool-for-the-blended-learning-environment
#12
Lolita Wikander, Stéphane L Bouchoucha
Adapting a course from face to face to blended delivery necessitates that assessments are modified accordingly. In Australia the Objective Structured Clinical Assessment tool, as a derivative from the Objective Structured Clinical Examination, has been used in the face-to-face delivery mode as a formative or summative assessment tool in medicine and nursing since 1990. The Objective Structured Clinical Assessment has been used at Charles Darwin University to assess nursing students' simulated clinical skills prior to the commencement of their clinical placements since 2008...
September 18, 2017: Nurse Education in Practice
https://www.readbyqxmd.com/read/28942061/the-behavioral-and-cognitive-relevance-of-time-varying-dynamic-changes-in-functional-connectivity
#13
REVIEW
Jessica R Cohen
Recent advances in neuroimaging methods and analysis have led to an expanding body of research that investigates how large-scale brain network organization dynamically adapts to changes in one's environment, including both internal state changes and external stimulation. It is now possible to detect changes in functional connectivity that occur on the order of seconds, both during an unconstrained resting state and during the performance of constrained cognitive tasks. It is thought that these dynamic, time-varying changes in functional connectivity, often referred to as dynamic functional connectivity (dFC), include features that are relevant to behavior and cognition...
September 20, 2017: NeuroImage
https://www.readbyqxmd.com/read/28941792/multidisciplinary-evaluation-of-an-emergency-department-nurse-navigator-role-a-mixed-methods-study
#14
Melanie Jessup, Paul Fulbrook, Frances B Kinnear
AIM: To utilise multidisciplinary staff feedback to assess their perceptions of a novel emergency department nurse navigator role and to understand the impact of the role on the department. BACKGROUND: Prolonged emergency department stays impact patients, staff and quality of care, and are linked to increased morbidity and mortality. One innovative strategy to facilitate patient flow is the navigator: a nurse supporting staff in care delivery to enhance efficient, timely movement of patients through the department...
September 20, 2017: Australian Critical Care: Official Journal of the Confederation of Australian Critical Care Nurses
https://www.readbyqxmd.com/read/28941691/dynamic-profiling-of-different-ready-to-drink-fermented-dairy-products-a-comparative-study-using-temporal-check-all-that-apply-tcata-temporal-dominance-of-sensations-tds-and-progressive-profile-pp
#15
Erick A Esmerino, John C Castura, Juliana P Ferraz, Elson R Tavares Filho, Ramon Silva, Adriano G Cruz, Mônica Q Freitas, Helena M A Bolini
Despite the several differences in ingredients, processes and nutritional values, dairy foods as yogurts, fermented milks and milk beverages are widely accepted worldwide, and although they have their sensory profiling normally covered by descriptive analyses, the temporal perception involved during the consumption are rarely considered. In this sense, the present work aimed to assess the dynamic sensory profile of three categories of fermented dairy products using different temporal methodologies: Temporal Dominance of Sensations (TDS), Progressive Profiling (PP), Temporal CATA (TCATA), and compare the results obtained...
November 2017: Food Research International
https://www.readbyqxmd.com/read/28941248/lipolysis-and-aroma-generation-as-mechanisms-involved-in-masking-boar-taint-in-sodium-reduced-fermented-sausages-inoculated-with-d-hansenii-yeast
#16
Sara Corral, Carmela Belloch, José J López-Díez, Mónica Flores
BACKGROUND: The use of boar back fat for processing of fermented sausages may cause the presence of abnormal odours. In dry-cured products, ripening time is essential to develop the sensory characteristics. Yeast has been proposed as an alternative to mask boar taint odour through its metabolic activity but it is necessary to elucidate which mechanisms are involved. The aim is to study the effect of D. hansenii inoculation on the lipolysis process and generation of aroma compounds in fermented sausages manufactured with boar back fat at two different ripening times...
September 23, 2017: Journal of the Science of Food and Agriculture
https://www.readbyqxmd.com/read/28940708/clinical-and-patient-reported-outcomes-of-zirconia-based-implant-fixed-dental-prostheses-results-of-a-prospective-case-series-5%C3%A2-years-after-implant-placement
#17
Benedikt Christopher Spies, Siegbert Witkowski, Kirstin Vach, Ralf-Joachim Kohal
OBJECTIVE: To evaluate the clinical and patient-reported outcome of all-ceramic zirconia implant supported fixed dental prostheses (FDPs) 5 years after implant installation. MATERIALS AND METHODS: Thirteen patients were treated with two terminally placed one-piece zirconia implants for a three-unit FDP each. The FDPs consisted of a CAD/CAM-fabricated zirconia framework over-pressed with a fluor-apatite veneering ceramic and were adhesively cemented. Survival and success were assessed by applying modified US Public Health Service (USPHS) criteria and preparation of Kaplan-Meier (KM) plots...
September 21, 2017: Clinical Oral Implants Research
https://www.readbyqxmd.com/read/28939461/perception-of-employment-by-the-veterans-participating-in-the-national-veterans-wheelchair-games-a-survey-study
#18
William Kim, Leah Lee, Daniel Lans, David Tostenrude, Kenneth Lee
BACKGROUND: Employment in those with disability is an important rehabilitation goal along with achieving some measure of functional independence and at the same time one of the most difficult goals to achieve. The number of people with disabilities participating in adaptive sports has been steadily rising over the years. A few studies have looked at the relationship between physical fitness and employment status in those with disability, but there have been no studies that focused on the results of organized adaptive sports events affecting employment outcome...
September 19, 2017: PM & R: the Journal of Injury, Function, and Rehabilitation
https://www.readbyqxmd.com/read/28939428/cd36-is-a-candidate-lipid-sensor-involved-in-the-sensory-detection-of-fatty-acid-in-zebrafish
#19
Haiyang Liu, Yanping Xu, Ying Wang, Shenjie Zhong, Min Wang, Pengyan Lin, Hongyan Li, Zhenhui Liu
Recently more and more evidences raise the possibility for the taste system in the role of the perception of lipids in mammals, and the fatty acid receptor CD36 has been proved to be as an important candidate receptor of fat taste. Fish has different taste modality with mammals. No information was known about the function of cd36 in fish taste till now. Here, using in situ hybridization and immunofluorescence technologies, we showed that fish cd36/Cd36 localized in taste buds. Real-time PCR technology demonstrated that, in zebrafish cd36 (zcd36)-transfected cells, linoleic acid (LA) increased the expression level of tryptophan hydroxylase-1 (TPH-1), which encodes the enzyme involved in the biosynthesis of monoamine neurotransmitter of 5-HT...
September 19, 2017: Physiology & Behavior
https://www.readbyqxmd.com/read/28939098/structural-equations-modelling-of-drivers-speed-selection-using-environmental-driver-and-risk-factors
#20
Reut Sadia, Shlomo Bekhor, Abishai Polus
Drivers' speed has significant implications on road users' safety in general, and particularly so if a crash occurs. This paper explores the influence of environmental and road characteristics, situational factors, and individual characteristics on drivers' observed speed selection in a simulator experiment. The paper presents a theoretical framework for drivers' speed selection, and applies structural equation modeling for the various factors examined. The simulator experiments collected data of 111 drivers driving in 4 different scenarios composed of 22 segments for each scenario...
September 19, 2017: Accident; Analysis and Prevention
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