Read by QxMD icon Read

hydrogen peroxide decontamination

Aaron Hubbard, Thomas Reodl, Ada Hui, Stephanie Knueppel, Kirk Eppler, Siegfried Lehnert, Yuh-Fun Maa
A monoclonal antibody drug product (DP) manufacturing process was transferred to a different production site, where aseptic filling took place within an isolator that was sanitized using vapor phase hydrogen peroxide (VPHP). A quality-by-design approach was applied for study design to understand the impact of VPHP uptake in the isolator on DP quality. A combination of small-scale and manufacturing-scale studies was performed to evaluate the sensitivity of the monoclonal antibody to hydrogen peroxide (H2O2) as well as VPHP uptake mechanisms during the filling process...
March 15, 2018: PDA Journal of Pharmaceutical Science and Technology
F N J Frakking, W S Bril, J C Sinnige, J E van 't Klooster, B A W de Jong, E J van Hannen, M Tersmette
BACKGROUND: A large outbreak of three epidemic vancomycin-resistant Enterococcus faecium (VRE) clones affected our hospital for almost two years. AIM: To describe the strategy to successfully control this outbreak and eradicate VRE from our hospital. METHODS: Infection control interventions started after detection of VRE in three patients. After ongoing transmission despite isolation precautions, cleaning and contact tracing, hospital-wide surveillance was started...
February 20, 2018: Journal of Hospital Infection
Emile S Massima Mouele, Olanrewaju Ojo Fatoba, Omotola Babajide, Kassim O Badmus, Leslie F Petrik
Advanced oxidation processes (AOPs) particularly non-thermal plasmas based on electrical discharges have been widely investigated for water and wastewater treatment. Dielectric barrier discharges (DBDs) generate large amounts of selective and non-selective reactive oxygen species (ROS) such as ozone, hydrogen peroxide, atomic oxygen, superoxide molecular anions and hydroxyl radicals, having been proved to be efficient for water decontamination among various forms of electrical discharge systems. The detection and quantification methods of these oxygen species in non-thermal plasmas have been reviewed...
February 14, 2018: Environmental Science and Pollution Research International
F Carniato, C Bisio, C Evangelisti, R Psaro, V Dal Santo, D Costenaro, L Marchese, M Guidotti
A class of heterogeneous catalysts based on commercial bentonite from natural origin, containing at least 80 wt% of montmorillonite clay, was designed to transform selectively and under mild conditions toxic organosulfur and organophosphorus chemical warfare agents into non-noxious products with a reduced impact on health and environment. The bentonite from the natural origin was modified by introducing iron species and acid sites in the interlayer space, aiming to obtain a sorbent with strong catalytic oxidising and hydrolytic properties...
February 14, 2018: Dalton Transactions: An International Journal of Inorganic Chemistry
Elisabeth Eschlbeck, Christina Seeburger, Ulrich Kulozik
AIMS: To investigate the influence of surface hydrophobicity of carrier material and bacterial spores of Bacillus subtilis SA 22 and Bacillus atrophaeus (DSM 675) on spore inactivation with condensing hydrogen peroxide gas. METHODS AND RESULTS: Surface hydrophobicity of bacterial spores and carrier material was determined by means of contact angle measurement. Spores of Bacillus subtilis showed water contact angles of 90 °, spores of Bacillus atrophaeus showed water contact angles of 42 °...
January 16, 2018: Journal of Applied Microbiology
Brian Petrovsky, Eric Monnet
OBJECTIVE: To determine the efficacy of repeated decontamination and sterilization of a disposable port intended for 1-time use during single-incision laparoscopy. STUDY DESIGN: Experimental; prospective, controlled design. METHODS: Six single-access ports used 4 times and 6 single-access ports used 8 times to perform various clean, minimally invasive surgeries were evaluated. Ports were decontaminated in an enzymatic cleaner (dilution, 3:100) and cleaned with a scrub brush for 5 minutes...
December 8, 2017: Veterinary Surgery: VS
William R Richter, Joseph P Wood, Morgan Q S Wendling, James V Rogers
The inactivation of Bacillus anthracis spores on subway and used subway railcar materials was evaluated using fogged peracetic acid/hydrogen peroxide (PAA) and hydrogen peroxide (H2 O2 ). A total of 21 separate decontamination tests were conducted using bacterial spores of both B. anthracis Ames (B.a.) and Bacillus atrophaeus (B.g.) inoculated onto several types of materials. Tests were conducted using commercial off-the-shelf fogging equipment filled with either PAA or H2 O2 to fumigate a ∼15 cubic meter chamber under uncontrolled ambient relative humidity and controlled temperature (10 or 20 °C) from 8 to 168 h...
January 15, 2018: Journal of Environmental Management
Samuel Yui, Shanom Ali, Monika Muzslay, Annette Jeanes, A Peter R Wilson
OBJECTIVE To identify, using a novel enhanced method of recovery, environmental sites where spores of Clostridium difficile persist despite cleaning and hydrogen peroxide aerial decontamination. DESIGN Cohort study. SETTING Tertiary referral center teaching hospital. METHODS In total, 16 sites representing high-frequency contact or difficult-to-clean surfaces in a single-isolation room or bed area in patient bed bays were sampled before and after terminal or hydrogen peroxide disinfection using a sponge swab...
December 2017: Infection Control and Hospital Epidemiology
Yingwang Ye, Maofeng Zhang, Rui Jiao, Na Ling, Xiyan Zhang, Liaowang Tong, Haiyang Zeng, Jumei Zhang, Qingping Wu
Presence of Cronobacter malonaticus in powdered infant formula (PIF) poses a high risk to infant and public health. Cronobacter malonaticus has been widely distributed in food and food processing environments, and the true origin of C. malonaticus in PIF is poorly understood. Control and prevention of C. malonaticus is necessary for achieving microbial safety of PIF. However, little information about decontamination of C. malonaticus is available. In this study, effects of hydrogen peroxide on inactivation and morphological changes of C...
October 25, 2017: Journal of Dairy Science
Sanping Zhao, Hailing Xi, Yanjun Zuo, Qi Wang, Zhicheng Wang, Zengyuan Yan
(13)C NMR spectra showed that peroxymonocarbonate (HCO4(-)) was generated in the NaHCO3-activated H2O2 solution and pH was a key factor in its production. A cycle for the bicarbonate anion was proposed as HCO3(-)→HCO3 → (CO2)2*→CO2(aq)→HCO4(-) (H2CO4)→HCO3(-) (HCO3) basing on the results of NMR, electron paramagnetic resonance, chemiluminescence analysis. In this cycle, (CO2)2* was the key intermediate and (CO2)2*→2CO2+hv was the rate controlling step. Thioanisole and paraoxon, the simulants of sulfur mustard gas and nerve gas, respectively, were efficiently decontaminated by the NaHCO3-activated H2O2 solution...
October 2, 2017: Journal of Hazardous Materials
Ozge Surucu, Serdar Abaci
Sterilization is the certain and absolute decontamination of microorganisms totally from all manner of alive and active species. Sterilization devices used in the sterilization processes are between laboratory and external patient application devices of biomedical device technology, and they are designed to remove equipments from germs. The application potential of hetarilazo indole based azo dyes in the biomedical sterilization are known and azo dyes come into prominence in this class because of simplicity of their synthesis and procurement of low-cost raw materials...
September 27, 2017: Journal of the Mechanical Behavior of Biomedical Materials
Kevin P Sullivan, Wade A Neiwert, Huadong Zeng, Anil K Mehta, Qiushi Yin, Daniel A Hillesheim, Skanda Vivek, Panchao Yin, Daniel L Collins-Wildman, Eric R Weeks, Tianbo Liu, Craig L Hill
We report the synthesis and characterization of a new class of organic/inorganic hybrid polymers composed of covalently-bound 1,3,5-benzenetricarboxamide linkers and anionic polyoxovanadate clusters with varying counter-cations. These materials form gels within seconds upon contact with polar aprotic organic liquids and catalyze the degradation of odorants and toxic molecules under mild conditions including aerobic oxidation of thiols, hydrogen peroxide-catalyzed oxidation of sulfides, and hydrolysis of organophosphate chemical warfare agent analogues...
October 6, 2017: Chemical Communications: Chem Comm
S F Leow-Dyke, P Rooney, J N Kearney
Decellularised tissue allografts have been used in reconstructive surgical applications and transplantation for many years. Some of the current methods of sterilisation have a detrimental effect on the tissue graft structure and function. The anti-microbial activity of cupric ions and hydrogen peroxide (H2O2) are well known however their combined application is not currently utilised as a decontamination agent in the tissue banking world sector. The aim of this study was to determine the combined concentrations of copper chloride (CuCl2) and H2O2 that have the optimal bactericidal and sporicidal activity on decellularised (dCELL) human dermis...
September 26, 2017: Cell and Tissue Banking
M Biswal, S M Rudramurthy, N Jain, A S Shamanth, D Sharma, K Jain, L N Yaddanapudi, A Chakrabarti
BACKGROUND: Multidrug-resistant Candida auris infection has been reported from five continents in recent years. The prevalence of C. auris invasive infection has been estimated at 5.3% for intensive-care-acquired candidaemia in India. The transmission of the organism between the patients and from environment to patients is rapid. AIM: To understand the intra-hospital dynamics of C. auris transmission and to determine the possible interventions to prevent its spread...
December 2017: Journal of Hospital Infection
A Robustillo-Rodela, V Pérez-Blanco, M A Espinel Ruiz, G Ruiz Carrascoso, J C Figueira Iglesias, D Abad Martín
BACKGROUND: This report describes a double outbreak of OXA-48-producing Enterobacteriaceae (OXA-48-PE) and multidrug-resistant Acinetobacter baumannii (MRAB) in an intensive care unit (ICU) and the effectiveness of measures implemented, including decontamination with vaporized hydrogen peroxide (VHP). METHODS: Affected patients were isolated in a confined area and cared for by dedicated personnel. Four percent chlorhexidine soap was used for patient daily hygiene...
December 1, 2017: American Journal of Infection Control
Alireza Abdolrasouli, Darius Armstrong-James, Lisa Ryan, Silke Schelenz
Candida auris has caused nosocomial infections and transmissions within hospital settings. As little is known about the efficacy of skin and environmental decontamination products to kill C. auris, this study investigated the in vitro activity of chlorine, chlorhexidine, iodine povidone and vaporised hydrogen peroxide products against C. auris. H2 O2 vapour showed 96.6%-100% effective killing of C. auris. All isolates were inhibited by chlorhexidine gluconate concentrations at 0.125%-1.5% and for iodinated povidone at 0...
September 5, 2017: Mycoses
Elisabeth Eschlbeck, Simon A W Bauer, Ulrich Kulozik
Bacillus subtilis spores are often used as biological indicators (BI) to monitor decontamination processes with gaseous hydrogen peroxide. Results in practical inactivation validation tests, however, vary considerably with no available explanation so far. This study reports on the effect of cultivation pH on spore surface hydrophobicity. Surface hydrophobicity is suspected to have an impact on the decontamination of technical surfaces such as packaging material when gaseous, condensing hydrogen peroxide is applied...
December 2017: AMB Express
B M Petit, F C Almeida, T R Uchiyama, F O C Lopes, K H Tino, J Chewins
An evaluation was made of the efficacy of 35% hydrogen peroxide vapour (HPV) against foot-and-mouth disease virus (FMDV) in a biosafety facility. Biological indicators (BIs) were produced using three serotypes of FMDV, all with a titre of ≥10(6) TCID50 per ml. Fifteen BIs of each serotype were distributed across five locations, throughout a 30-m(3) airlock chamber, producing a total of 45 BIs. Thirty-five percent HPV was generated and applied using a Bioquell vaporization module located in the centre of the chamber...
October 2017: Letters in Applied Microbiology
A Cabrera Reina, S Miralles-Cuevas, J L Casas López, J A Sánchez Pérez
This study evaluates the combined effect of photo-catalyst concentration and irradiance level on photo-Fenton efficiency when this treatment is applied to industrial wastewater decontamination. Three levels of irradiance (18, 32 and 46W/m(2)) and three iron concentrations (8, 20 and 32mg/L) were selected and their influence over the process studied using a raceway pond reactor placed inside a solar box. For 8mg/L, it was found that there was a lack of catalyst to make use of all the available photons. For 20mg/L, the treatment always improved with irradiance indicating that the process was photo-limited...
December 15, 2017: Science of the Total Environment
Shuanghuan Guo, Runze Huang, Haiqiang Chen
With the demand for fresh produce increases in recent decades, concerns for microbiological safety of fresh produce are also raised. To identify effective ultraviolet (UV) light treatment for fresh produce decontamination, we first determined the effect of three forms of UV treatment, dry UV (samples were treated by UV directly), wet UV (samples were dipped in water briefly and then exposed to UV), and water-assisted UV (samples were treated by UV while being immersed in agitated water) on inactivation of Salmonella inoculated on tomatoes and fresh-cut lettuce...
September 18, 2017: International Journal of Food Microbiology
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"