keyword
https://read.qxmd.com/read/38509876/gdf10-and-ido1-as-a-thyroid-cancer-prognostic-biomarker-associated-with-immune-infiltration
#21
JOURNAL ARTICLE
Zhao-Bao Lv, Jun-Jing Zhang, Cheng Xiang
OBJECTION: The aim of this work is to screen the immune-related genes to predict the prognosis and provide a new direction of treatment for patients with thyroid cancer (THCA). METHODS: The mRNA and clinical features of THCA patients were collected from the Cancer Genome Atlas (TCGA) databases. The immune-related genes were obtained from the ImmPort databases. The bio-information methods were performed to screen the differential expression genes (DEGs) and genes related to immunity between the THCA patients and normal individuals...
March 30, 2024: Heliyon
https://read.qxmd.com/read/38508935/prognostic-evaluation-for-hepatocellular-carcinoma-with-portal-vein-tumor-thrombus-patients-treated-with-transarterial-chemoembolization-plus-molecular-targeted-therapies-development-and-validation-of-the-abps-score
#22
JOURNAL ARTICLE
Kaicai Liu, Xiaomin Zheng, Jiaying Dai, Changlong Hou, Dong Lu, Bensheng Zhao, Shiwu Yin, Guoxiang Wang, Qisheng Cao, Bo Jiang, Songxue Gao, Xudong Huang, Jun Xie, Yudong Zhang, Shuangsheng Li, Aiwu Zhang, Wei Yang, Song Wang, Yulin Tan, Wanyin Shi, Weifu Lv, Xingwang Wu
RATIONALE AND OBJECTIVES: Transarterial chemoembolization (TACE) plus molecular targeted therapies has emerged as the main approach for treating hepatocellular carcinoma (HCC) with portal vein tumor thrombus (PVTT). A robust model for outcome prediction and risk stratification of recommended TACE plus molecular targeted therapies candidates is lacking. We aimed to develop an easy-to-use tool specifically for these patients. METHODS: A retrospective analysis was conducted on 384 patients with HCC and PVTT who underwent TACE plus molecular targeted therapies at 16 different institutions...
March 19, 2024: Academic Radiology
https://read.qxmd.com/read/38508401/an-evolutionary-theory-on-virus-mutation-in-covid-19
#23
JOURNAL ARTICLE
Liaofu Luo, Jun Lv
With the rapid evolution of SARS-CoV-2, the emergence of new strains is an intriguing question. This paper presents an evolutionary theory to analyze the mutations of the virus and identify the conditions that lead to the generation of new strains. We represent the virus variants using a 4-letter sequence based on amino acid mutations on the spike protein and employ an n-distance algorithm to derive a variant phylogenetic tree. We show that the theoretically-derived tree aligns with experimental data on virus evolution...
March 18, 2024: Virus Research
https://read.qxmd.com/read/38505082/effects-of-case-volume-on-short-and-long-term-outcomes-following-cadaveric-lung-transplantation-in-japan
#24
JOURNAL ARTICLE
Masayuki Chida, Takashi Inoue, Takahiro Nakajima, Yoshinori Okada, Hisashi Oishi, Jun Nakajima, Masaaki Sato, Ichiro Yoshino, Hidemi Suzuki, Daisuke Nakajima, Yasushi Shintani, Takashi Kanou, Shinichi Toyooka, Kentaroh Miyoshi, Takeshi Shiraishi, Toshihiko Sato, Keitaro Matsumoto, Takeshi Nagayasu, Yasushi Hoshikawa, Yasushi Matsuda, Sumiko Maeda, Hiroshi Date
BACKGROUND: Despite the low number of lung transplantations (LTs) in Japan, 10 LT facilities are accredited and good outcomes have been reported. A database review was conducted to clarify the impact of case volume at LT facilities in Japan on short- and long-term outcomes. METHODS: All cadaveric LT cases treated between 2000 and 2021 in Japan were analyzed using the database of the Japanese Society of Lung and Heart-Lung Transplantation (JSLHT). The nine institutions represented were categorized into the low-volume (LV; <80 cumulative LT cases, <8 LTs/year, n=5) and high-volume (HV; ≥80 cumulative LT cases, ≥8 LTs/year, n=4) centers...
February 29, 2024: Journal of Thoracic Disease
https://read.qxmd.com/read/38505042/-hoxa5-induced-lncrna-dnm3os-promotes-human-embryo-lung-fibroblast-fibrosis-via-recruiting-ezh2-to-epigenetically-suppress-tsc2-expression
#25
JOURNAL ARTICLE
Hong Lv, Xingjia Qian, Zhengzheng Tao, Jun Shu, Dongfang Shi, Jing Yu, Guiqin Fan, Qiuhong Qian, Luhong Shen, Bing Lu
BACKGROUND: Idiopathic pulmonary fibrosis (IPF) is an unrepairable disease that results in lung dysfunction and decreased quality of life. Prevention of pulmonary fibrosis is challenging, while its pathogenesis remains largely unknown. Herein, we investigated the effect and mechanism of long non-coding RNA (lncRNA) DNM3OS /Antisense RNA in the pathogenesis of pulmonary fibrosis. METHODS: EdU (5-ethynyl-2'-deoxyuridine) and wound healing assays were employed to evaluate the role of DNM3OS on cell proliferation and migration...
February 29, 2024: Journal of Thoracic Disease
https://read.qxmd.com/read/38505038/optimal-therapeutic-strategy-for-non-small-cell-lung-cancer-with-thoracic-extrathoracic-metastasis-a-study-based-on-seer-database
#26
JOURNAL ARTICLE
Zhehao He, Xuqi Sun, Jinming Xu, Luming Wang, Jun Cheng, Wang Lv, Jian Hu
BACKGROUND: Non-small cell lung cancer (NSCLC) patients with extrathoracic metastasis (EM) are a highly heterogeneous cohort. Some of these patients could benefit from primary tumor surgery. This study aimed to identify potential NSCLC patients with EM suitable for primary tumor resection and to determine the optimal therapeutic strategy. METHODS: NSCLC patients with EM were extracted from the Surveillance, Epidemiology and End Results database between 2010 and 2015...
February 29, 2024: Journal of Thoracic Disease
https://read.qxmd.com/read/38503925/increased-gene-dosage-of-rfwd2-causes-autistic-like-behaviors-and-aberrant-synaptic-formation-and-function-in-mice
#27
JOURNAL ARTICLE
Yong-Xia Li, Zhi-Nei Tan, Xu-Hui Li, Boyu Ma, Frank Adu Nti, Xiao-Qiang Lv, Zhen-Jun Tian, Riqiang Yan, Heng-Ye Man, Xin-Ming Ma
Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterized by impaired social interactions, communication deficits and repetitive behaviors. A study of autistic human subjects has identified RFWD2 as a susceptibility gene for autism, and autistic patients have 3 copies of the RFWD2 gene. The role of RFWD2 as an E3 ligase in neuronal functions, and its contribution to the pathophysiology of ASD, remain unknown. We generated RFWD2 knockin mice to model the human autistic condition of high gene dosage of RFWD2...
March 19, 2024: Molecular Psychiatry
https://read.qxmd.com/read/38503426/mechanism-of-ncnts-growth-on-foamed-nickel-and-thus-prepared-ps-hydrogenation-high-performance-carrier-ncnts-fn
#28
JOURNAL ARTICLE
Jun-Yang Yan, Chun-Yan Cao, Gui-Ping Cao, Shao-Feng Pan, Hui Lv, Alaaddin M M Saeed
Traditional heterogeneous catalysts are affected in the catalytic hydrogenation of PS by the scale effect, viscosity effect, adhesion effect, and conformational effect, resulting in poor activity and stability. Monolithic Pd-CNTs@FN catalysts could eliminate or weaken the impact of these negative effects. We grew nitrogen-doped carbon nanotubes (NCNTs) on monolithic-foamed nickel (FN) and investigate their growth mechanism. Meanwhile, the feasibility of using the NCNTs@FN carrier for PS hydrogenation reaction was also verified...
March 19, 2024: Langmuir: the ACS Journal of Surfaces and Colloids
https://read.qxmd.com/read/38496710/platelet-rna-sequencing-reveals-profile-of-caffeic-acid-affecting-hemostasis-in-mice
#29
JOURNAL ARTICLE
Jun Deng, Lv Xiong, Yajie Ding, Yaohua Cai, Zhaolin Chen, Fengjuan Fan, Shanshan Luo, Yu Hu
BACKGROUND: Caffeic acid (CA) is a naturally occurring phenolic compound with diverse pharmacologic properties. CA plays a crucial role in hemostasis by increasing platelet count. However, the mechanism by which CA regulates platelets to promote hemostasis remains unclear. OBJECTIVES: We aim to identify the potential target pathways and genes by which CA regulates platelets to promote hemostasis. METHODS: We performed RNA sequencing (RNA-seq) analysis of mouse platelet pools in both the CA-gavaged group and phosphate-buffered saline-gavaged group...
February 2024: Research and Practice in Thrombosis and Haemostasis
https://read.qxmd.com/read/38495513/rapid-detection-of-multidrug-resistance-in-tuberculosis-using-nanopore-based-targeted-next-generation-sequencing-a-multicenter-double-blind-study
#30
JOURNAL ARTICLE
Aimei Liu, Sang Liu, Kangyan Lv, Qingdong Zhu, Jun Wen, Jianpeng Li, Chengyuan Liang, Xuegang Huang, Chunming Gong, Qingfeng Sun, Hongcang Gu
BACKGROUND: Resistance to anti-tuberculous drugs is a major challenge in the treatment of tuberculosis (TB). We aimed to evaluate the clinical availability of nanopore-based targeted next-generation sequencing (NanoTNGS) for the diagnosis of drug-resistant tuberculosis (DR-TB). METHODS: This study enrolled 253 patients with suspected DR-TB from six hospitals. The diagnostic efficacy of NanoTNGS for detecting Mycobacterium tuberculosis and its susceptibility or resistance to first- and second-line anti-tuberculosis drugs was assessed by comparing conventional phenotypic drug susceptibility testing (pDST) and Xpert MTB/RIF assays...
2024: Frontiers in Microbiology
https://read.qxmd.com/read/38491161/notoginsenoside-r1-promotes-lgr5-stem-cell-and-epithelium-renovation-in-colitis-mice-via-activating-wnt-%C3%AE-catenin-signaling
#31
JOURNAL ARTICLE
Zhi-Lun Yu, Rui-Yang Gao, Cheng Lv, Xiao-Long Geng, Yi-Jing Ren, Jing Zhang, Jun-Yu Ren, Hao Wang, Fang-Bin Ai, Zi-Yi Wang, Bei-Bei Zhang, Dong-Hui Liu, Bei Yue, Zheng-Tao Wang, Wei Dou
Inflammatory bowel disease (IBD) is characterized by persistent damage to the intestinal barrier and excessive inflammation, leading to increased intestinal permeability. Current treatments of IBD primarily address inflammation, neglecting epithelial repair. Our previous study has reported the therapeutic potential of notoginsenoside R1 (NGR1), a characteristic saponin from the root of Panax notoginseng, in alleviating acute colitis by reducing mucosal inflammation. In this study we investigated the reparative effects of NGR1 on mucosal barrier damage after the acute injury stage of DSS exposure...
March 15, 2024: Acta Pharmacologica Sinica
https://read.qxmd.com/read/38488318/bombyx-mori-voltage-dependent-anion-selective-channel-induces-programmed-cell-death-to-defend-against-bombyx-mori-nucleopolyhedrovirus-infection
#32
JOURNAL ARTICLE
Jun-Li Lv, Wen-Qing Lai, Yu-Quan Gong, Kai-Yi Zheng, Xiao-Ying Zhang, Zhan-Peng Lu, Xue-Yang Wang, Li-Shang Dai, Mu-Wang Li
BACKGROUND: Voltage-dependent anion-selective channels (VDACs) serve as pore proteins within mitochondrial membrane, aiding in the regulation of cell life and cell death. While the occurrence of cell death is crucial for the defense against virus infection, the function played by VDAC in Bombyx mori, in response to the influence of Bombyx mori nucleopolyhedrovirus (BmNPV), remains unclear. RESULTS: BmVDAC was found to be relatively highly expressed both during embryonic development and in the Malpighian tubule and midgut...
March 15, 2024: Pest Management Science
https://read.qxmd.com/read/38487712/macrophage-exosomes-modified-by-mir-365-2-5p-promoted-osteoblast-osteogenic-differentiation-by-targeting-olfml1
#33
JOURNAL ARTICLE
Caiyao Hou, Yujue Zhang, Zhaoyong Lv, Yurun Luan, Jun Li, Chunxiu Meng, Kun Liu, Xin Luo, Liyu Chen, Fengzhen Liu
In the bone immune microenvironment, immune cells can regulate osteoblasts through a complex communication network. Macrophages play a central role in mediating immune osteogenesis, exosomes derived from them have osteogenic regulation and can be used as carriers in bone tissue engineering. However, there are problems with exosomal therapy alone, such as poor targeting, and the content of loaded molecules cannot reach the therapeutic concentration. In this study, macrophage-derived exosomes modified with miR-365-2-5p were developed to accelerate bone healing...
2024: Regenerative Biomaterials
https://read.qxmd.com/read/38485933/correction-lncrna-snhg1-and-rna-binding-protein-hnrnpl-form-a-complex-and-coregulate-cdh1-to-boost-the-growth-and-metastasis-of-prostate-cancer
#34
Xiao Tan, Wen-Bin Chen, Dao-Jun Lv, Tao-Wei Yang, Kai-Hui Wu, Li-Bin Zou, Junqi Luo, Xu-Min Zhou, Guo-Chang Liu, Fang-Peng Shu, Xiang-Ming Mao
No abstract text is available yet for this article.
March 14, 2024: Cell Death & Disease
https://read.qxmd.com/read/38483956/the-prognostic-impact-of-follow-up-cardiac-mibg-imaging-on-lv-trajectory-after-acute-decompensation
#35
JOURNAL ARTICLE
Kiyomi Kayama, Takahisa Yamada, Masahiro Seo, Tetsuya Watanabe, Takashi Morita, Masato Kawasaki, Atsushi Kikuchi, Tsutomu Kawai, Jun Nakamura, Masatake Fukunami
AIMS: Cardiac metaiodobenzylguanidine (MIBG) imaging provides prognostic information in patients with heart failure. Recently, the trajectory of left ventricular ejection fraction (LVEF) has been a focus in patients with reduced LVEF admitted for acute decompensated heart failure (ADHF). We sought to investigate the prognostic value of follow-up cardiac MIBG imaging in ADHF patients with reduced LVEF in relation to LVEF trajectory. METHODS AND RESULTS: We prospectively studied 145 ADHF patients with reduced LVEF<40%...
March 14, 2024: European Heart Journal Cardiovascular Imaging
https://read.qxmd.com/read/38479170/refinement-of-kinetic-model-and-understanding-the-role-of-dichloride-radical-cl-2-%C3%A2-in-radical-transformation-in-the-uv-nh-2-cl-process
#36
JOURNAL ARTICLE
Haochen Zhang, Maoju Jiang, Peng Su, Qixiao Lv, Ge Zeng, Linqian An, Jiachun Cao, Yang Zhou, Shane Allen Snyder, Jun Ma, Tao Yang
The ultraviolet/monochloramine (UV/NH2 Cl) process is an emerging advanced oxidation process with promising prospects in water treatment. Previous studies developed kinetic models of UV/NH2 Cl for simulating radical concentrations and pollutant degradation. However, the reaction rate constants of Cl2 •- with bicarbonate and carbonate (kCl2•-, HCO3- and kCl2•-, CO32- ) were overestimated in literature. Consequently, when dosing 1 mM chloride and 1 mM bicarbonate, the current models of UV/NH2 Cl severely under-predicted the experimental concentrations of three important radicals (i...
March 9, 2024: Water Research
https://read.qxmd.com/read/38477972/regioselective-deacetylation-of-peracetylated-deoxy-c-glycopyranosides-by-boron-trichloride-bcl-3
#37
JOURNAL ARTICLE
Shuangyuan Chen, Feifei Wei, Xinqiang Cheng, Ying Luo, Fancui Meng, Yuanwen Zhang, Wenqian Huang, Jun Lv, Hong Pan, Qingqing Wu, Guilong Zhao
A general approach for regioselective deacetylation at sugar 3-OH of peracetylated 6-deoxy- C -glucopyranosides mediated by BCl3 was developed. The approach could be extended to other sugar-derived 6-deoxy- C -glycopyranosides, such as those derived from mannose, galactose, and rhamnose, with deacetylation occurring at varied sugar hydroxyl groups, and further extended to 4-deoxy- C -glucopyranosides with deacetylation occurring at sugar 3-OH. The approach would enable access to synthetically challenging carbohydrate derivatives...
March 13, 2024: Journal of Organic Chemistry
https://read.qxmd.com/read/38477044/mir-34b-3p-mediated-regulation-of-stc2-and-fn1-enhances-chemosensitivity-and-inhibits-proliferation-in-cervical-cancer
#38
JOURNAL ARTICLE
Shanshan Jin, Wenting Wang, Xinrui Xu, Zhaowei Yu, Zihan Feng, Jun Xie, Huimin Lv
Dysregulation of microRNA (miRNA) expression in cancer is a significant factor contributing to the progression of chemoresistance. The objective of this study is to explore the underlying mechanisms by which miR-34b-3p regulates chemoresistance in cervical cancer (CC). Previous findings have demonstrated low expression levels of miR-34b-3p in both CC chemoresistant cells and tissues. In this study, we initially characterize the behavior of SiHa/DDP cells which are CC cells resistant to the chemotherapeutic drug cisplatin (DDP)...
March 13, 2024: Acta Biochimica et Biophysica Sinica
https://read.qxmd.com/read/38476368/corrigendum-sequential-pet-ct-and-pathological-biomarker-crosstalk-predict-response-to-pd-1-blockers-alone-or-combined-with-sunitinib-in-propensity-score-matched-cohorts-of-cancer-of-unknown-primary-treatment
#39
Youlong Wang, Qi Huang, Guanqing Zhong, Jun Lv, Qinzhi Guo, Yifei Ma, Xinjia Wang, Jiling Zeng
[This corrects the article DOI: 10.3389/fonc.2023.1191611.].
2024: Frontiers in Oncology
https://read.qxmd.com/read/38476185/tbss-analysis-of-white-matter-fasciculus-in-chronic-insomnia-and-the-relationship-with-sleep-quality-and-cognitive-function
#40
JOURNAL ARTICLE
Xiaoran Liu, Mingxing Han, Tongyu Lv, Jun Li, Xueyan Zhang
Eighty patients with chronic insomnia and 50 normal controls were selected. Evaluation scales included Pittsburgh Sleep Quality Index, Dysfunctional Beliefs and Attitudes about Sleep, Montreal Cognitive Assessment, Self-Rating Anxiety Scale, Self-Rating Depression Scale, Ruminative Responses Scale and Social Disability Screening Schedule. All patients and controls underwent whole-brain DTI scanning and Tract-Based Spatial Statistics (TBSS) analysis was performed. Chronic insomnia patients are mainly accompanied by white matter lesions of right posterior thalamic radiation, right sagittal tract, and right upper longitudinal tract...
October 2023: Sleep and Biological Rhythms
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