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Jun Lv

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https://www.readbyqxmd.com/read/29681853/caffeine-promotes-conversion-of-palmitic-acid-to-palmitoleic-acid-by-inducing-expression-of-fat-5-in-caenorhabditis-elegans-and-scd1-in-mice
#1
Xiaocui Du, Qin Huang, Yun Guan, Ming Lv, Xiaofang He, Chongye Fang, Xuanjun Wang, Jun Sheng
The synthesis and metabolism of fatty acids in an organism is related to many biological processes and is involved in several diseases. The effects of caffeine on fatty acid synthesis and fat storage in Caenorhabditis elegans and mice were studied. After 6 h of food deprivation, adult C. elegans were treated with 0.1 mg/mL caffeine for 24 h. Quantitative reverse-transcription polymerase chain reaction showed that, among all the genes involved in fat accumulation, the mRNA expression of fat-5 in caffeine-treated C...
2018: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29678580/microrna-185-inhibits-the-growth-and-proliferation-of-osteoblasts-in-fracture-healing-by-targeting-pth-gene-through-down-regulating-wnt-%C3%AE-catenin-axis-in-an-animal-experiment
#2
Chang-Jiang Yao, Yang Lv, Cheng-Jun Zhang, Jia-Xin Jin, Li-Hu Xu, Jin Jiang, Bin Geng, Hong Li, Ya-Yi Xia, Meng Wu
Fracture healing is a repair process of a mechanical discontinuity loss of force transmission, and pathological mobility of bone. Increasing evidence suggests that microRNA (miRNA) could regulate chondrocyte, osteoblast, and osteoclast differentiation and function, indicating miRNA as key regulators of bone formation, resorption, remodeling, and repair. Hence, during this study, we established a right femur fracture mouse model to explore the effect microRNA-185 (miR-185) has on osteoblasts in mice during fracture healing and its underlying mechanism...
April 17, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29676135/-protective-effect-of-longxue-tongluo-capsule-on-oxidized-low-density-lipoprotein-damage-to-human-umbilical-vein-endothelial-cells
#3
Hong-Mei Wang, Jian-Ming Zhou, Yao-Zhong Lv, Jun Zhou, Zhen-Zhong Wang, Wen-Zhe Huang, Peng-Fei Tu, Wei Xiao
To observe the protective effect of Longxue Tongluo capsule (LTC) on human umbilical vein endothelial cells (EAhy.926 cells) injury induced by oxidized low-density lipoprotein (ox-LDL, 100 mg·L⁻¹). The effect of the cell viability of LTCin alleviating OX-LDL-induced endothelial cell injury was determined by MTT and LDH assay. The effect of LTC on lactic dehydrogenase (LDH), nitric oxide (NO), super oxide dlsmutase (SOD) and malondialdehyde (MDA) levels were detected by corresponding assay kits according to manufacturer's instruction...
March 2018: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/29674272/copb2-promotes-cell-proliferation-and-tumorigenesis-through-up-regulating-yap1-expression-in-lung-adenocarcinoma-cells
#4
Xiaolin Pu, Jun Wang, Wei Li, Weifei Fan, Lin Wang, Yuan Mao, Shu Yang, Suyao Liu, Juqing Xu, Zhigang Lv, Lin Xu, Yongqian Shu
Lung adenocarcinoma is the most common subtype of non-small cell lung cancer and responsible for more than 500,000 deaths per year worldwide. In this study, we aimed to explore the effects of COPB2 in the progression of lung adenocarcinoma and its underlying mechanism. The mRNA and protein levels of COPB2 in tumor tissues and cell lines were determined by qRT-PCR and western blotting analysis. siRNAs and over-expressed vector targeting COPB2 were used to down-regulate and up-regulate COPB2 expression in lung adenocarcinoma cell lines H1975...
April 16, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29669314/three-novel-heterozygous-col4a4-mutations-result-in-three-different-collagen-type-iv-kidney-disease-phenotypes
#5
Ang Li, Er-Zhi Gao, Ying-Xia Cui, Jian-Hong Liu, Xing Lv, Xiu-Xiu Wei, Xin-Yi Xia, Chun-Lin Gao, Feng-Xia Liu, Zheng-Kun Xia, Asan, Zhi-Hong Liu, Xiao-Jun Li
Thin basement membrane nephropathy (TBMN), autosomal dominant Alport syndrome (ADAS), and focal segmental glomerulosclerosis (FSGS) are kidney diseases that differ in clinical diagnosis, treatment, and prognosis. Nevertheless, they may result from the same causative genes. Here, we report 3 COL4A4 heterozygous mutations (p.Gly208Arg, p.Ser513Glufs*2, and p.Met1617Cysfs*39) that lead to 3 different collagen type IV kidney disease phenotypes, manifesting as TBMN, ADAS, and FSGS. Using bioinformatics analyses and pedigree verification, we show that these novel variants are pathogenetic and cosegregate with TBMN, ADAS, and FSGS...
2018: Cytogenetic and Genome Research
https://www.readbyqxmd.com/read/29668705/age-at-natural-menopause-and-associated-factors-in-adult-women-findings-from-the-china-kadoorie-biobank-study-in-zhejiang-rural-area
#6
Meng Wang, Wei-Wei Gong, Ru-Ying Hu, Hao Wang, Yu Guo, Zheng Bian, Jun Lv, Zheng-Ming Chen, Li-Ming Li, Min Yu
OBJECTIVES: To investigate the factors associated with age at natural menopause in a large population of Chinese adult women. METHODS: This cross-sectional study was part of the baseline survey of China Kadoorie Biobank in Zhejiang Province. A total of 17,076 postmenopausal women were included in the present study. Relevant data of socio-demographic, lifestyle, dietary and reproductive characteristics were collected. Multinomial logistic regression models were used to examine the associated factors of age at natural menopause with adjusted odds ratios (ORs) and their 95% confidence intervals (CIs) were reported...
2018: PloS One
https://www.readbyqxmd.com/read/29667064/correction-to-formation-of-brominated-and-chlorinated-dioxins-and-its-prevention-during-a-pilot-test-of-mechanochemical-treatment-of-pcb-and-pbde-contaminated-soil
#7
Mengnan Lu, Tianwu Lv, Ying Li, Zheng Peng, Giovanni Cagnetta, Shouxiang Sheng, Jun Huang, Gang Yu, Roland Weber
The destruction of persistent organic pollutants(POPs) is a large challenge in particular in developing and emerging economies.
April 18, 2018: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29665837/the-cxcl5-cxcr2-axis-contributes-to-the-epithelial-mesenchymal-transition-of-nasopharyngeal-carcinoma-cells-by-activating-erk-gsk-3%C3%AE-snail-signalling
#8
Wen-Ze Qiu, Hai-Bo Zhang, Wei-Xiong Xia, Liang-Ru Ke, Jing Yang, Ya-Hui Yu, Hu Liang, Xin-Jun Huang, Guo-Ying Liu, Wang-Zhong Li, Yan-Qun Xiang, Tie-Bang Kang, Xiang Guo, Xing Lv
BACKGROUND: Distant metastasis is the major cause of treatment failure in patients with nasopharyngeal carcinoma (NPC). Although several biomarkers correlate with metastasis and prognosis, the molecular mechanisms of NPC development and progression remain unclear. METHODS: Quantitative RT-PCR (qRT-PCR), western blotting, cell growth, foci formation, migration and invasion assays, and xenograft mouse models were utilized to examine the expression levels and functions of the CXCL5/CXCR2 axis in NPC...
April 17, 2018: Journal of Experimental & Clinical Cancer Research: CR
https://www.readbyqxmd.com/read/29664164/ultrathin-chiral-metal-organic-frameworks-nanosheets-for-efficient-enantioselective-separation
#9
Jun Guo, Yin Zhang, Yanfei Zhu, Chang Long, Meiting Zhao, Meng He, Xiaofei Zhang, Jiawei Lv, Bing Han, Zhiyong Tang
Chiral metal-organic frameworks (CMOFs) nanosheets with only few layers in thickness remain a virgin land waiting for exploration. In this report, the first example of ultrathin CMOFs nanosheets is successfully fabricated via the confinement growth of two-dimensional (2D) chiral layers, which are assembled by helical metal-organic chains within microemulsion. Impressively, this convenient and easily scaled up inverse microemulsion protocol is capable of fabricating a series of 2D CMOFs nanosheets composed of variable metal node or alternative chiral ligand...
April 17, 2018: Angewandte Chemie
https://www.readbyqxmd.com/read/29649685/gross-beta-determination-in-drinking-water-using-scintillating-fiber-array-detector
#10
Wen-Hui Lv, Hong-Chang Yi, Tong-Qing Liu, Zhi Zeng, Jun-Li Li, Hui Zhang, Hao Ma
A scintillating fiber array detector for measuring gross beta counting is developed to monitor the real-time radioactivity in drinking water. The detector, placed in a stainless-steel tank, consists of 1096 scintillating fibers, both sides of which are connected to a photomultiplier tube. The detector parameters, including working voltage, background counting rate and stability, are tested, and the detection efficiency is calibrated using standard potassium chloride solution. Water samples are measured with the detector and the results are compared with those by evaporation method...
April 4, 2018: Applied Radiation and Isotopes
https://www.readbyqxmd.com/read/29648690/incremental-value-of-left-atrial-active-function-measured-by-speckle-tracking-echocardiography-in-patients-with-hypertrophic-cardiomyopathy
#11
Kaori Fujimoto, Katsuji Inoue, Makoto Saito, Haruhiko Higashi, Tamami Kono, Teruyoshi Uetani, Jun Aono, Takayuki Nagai, Kazuhisa Nishimura, Jun Suzuki, Takafumi Okura, Shuntaro Ikeda, Satoshi Nakatani, Jitsuo Higaki
PURPOSE: Hypertrophic cardiomyopathy (HCM) impairs left ventricular (LV) diastolic function leading to left atrial (LA) dilatation. Because Doppler echocardiography cannot accurately assess LV diastolic function in hearts with heterogeneous hypertrophy, assessment of LA function might be useful for risk stratification of patients with HCM. This study aimed to elucidate the impact of LA function on outcome in patients with patients. METHODS: Seventy-six patients with HCM who underwent echocardiographic and cardiac magnetic resonance imaging were retrospectively enrolled...
April 12, 2018: Echocardiography
https://www.readbyqxmd.com/read/29644407/different-recovery-processes-of-soil-ammonia-oxidizers-from-flooding-disturbance
#12
Fei Ye, Mao-Hua Ma, Huub J M Op den Camp, Antonis Chatzinotas, Lei Li, Ming-Quan Lv, Sheng-Jun Wu, Yu Wang
Understanding how microorganisms respond to environmental disturbance is one of the key focuses in microbial ecology. Ammonia-oxidizing bacteria (AOB) and archaea (AOA) are responsible for ammonia oxidation which is a crucial step in the nitrogen cycle. Although the physiology, distribution, and activity of AOA and AOB in soil have been extensively investigated, their recovery from a natural disturbance remains largely unknown. To assess the recovery capacities, including resistance and resilience, of AOA and AOB, soil samples were taken from a reservoir riparian zone which experienced periodically water flooding...
April 11, 2018: Microbial Ecology
https://www.readbyqxmd.com/read/29643992/description-of-organ-specific-phenotype-and-functional-characteristics-of-tissue-resident-lymphocytes-from-liver-transplantation-donor-and-research-on-immune-tolerance-mechanism-of-liver
#13
Yunpeng Shi, Ping Zhang, Guangyi Wang, Xingkai Liu, Xiaodong Sun, Xin Zhang, Haijun Li, Jun Qi, Lei Ding, Ting Li, Ruoyan Zhang, Yuguo Chen, Jianpeng Zhou, Guoyue Lv, Zhengkun Tu
Aim: Prior to transplantation, Donation after Cardiac Death (DCD) liver transplantation livers are perfused with preservation solution. Therefore, this provides an abundant source of human liver lymphocytes, as well as mesenteric lymph node and spleen for the study of lymphocyte subset diversity in the peripheral blood, lymph node, spleen and liver. Methods: Lymphocyte subsets were isolated and purified from peripheral blood, lymph node, spleen and liver perfusion, the phenotypic and functional analysis of the tissue resident lymphocyte were performed by flow cytometry...
March 20, 2018: Oncotarget
https://www.readbyqxmd.com/read/29643812/left-ventricular-wall-stress-is-sensitive-marker-of-hypertrophic-cardiomyopathy-with-preserved-ejection-fraction
#14
Xiaodan Zhao, Ru-San Tan, Hak-Chiaw Tang, Soo-Kng Teo, Yi Su, Min Wan, Shuang Leng, Jun-Mei Zhang, John Allen, Ghassan S Kassab, Liang Zhong
Hypertrophic cardiomyopathy (HCM) patients present altered myocardial mechanics due to the hypertrophied ventricular wall and are typically diagnosed by the increase in myocardium wall thickness. This study aimed to quantify regional left ventricular (LV) shape, wall stress and deformation from cardiac magnetic resonance (MR) images in HCM patients and controls, in order to establish superior measures to differentiate HCM from controls. A total of 19 HCM patients and 19 controls underwent cardiac MR scans. The acquired MR images were used to reconstruct 3D LV geometrical models and compute the regional parameters (i...
2018: Frontiers in Physiology
https://www.readbyqxmd.com/read/29628888/licochalcone-a-upregulates-nrf2-antioxidant-pathway-and-thereby-alleviates-acetaminophen-induced-hepatotoxicity
#15
Hongming Lv, Qingfei Xiao, Junfeng Zhou, Haihua Feng, Guowen Liu, Xinxin Ci
Acetaminophen (APAP) overdose-induced fatal hepatotoxicity is majorly characterized by overwhelmingly increased oxidative stress while enhanced nuclear factor-erythroid 2-related factor 2 (Nrf2) is involved in prevention of hepatotoxicity. Although Licochalcone A (Lico A) upregulates Nrf2 signaling pathway against oxidative stress-triggered cell injury, whether it could protect from APAP-induced hepatotoxicity by directly inducing Nrf2 activation is still poorly elucidated. This study aims to explore the protective effect of Lico A against APAP-induced hepatotoxicity and its underlying molecular mechanisms...
2018: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29626798/synthesis-and-biological-evaluation-of-clovamide-analogues-as-potent-anti-neuroinflammatory-agents-in-vitro-and-in-vivo
#16
Xiao-Long Hu, Jun Lin, Xian-Yu Lv, Jia-Hao Feng, Xiao-Qi Zhang, Hao Wang, Wen-Cai Ye
A series of clovamide analogues, namely, 1a-13a and 1b-13b, was synthesized and evaluated for their anti-neuroinflammatory activities using BV-2 microglia cells. Among these compounds, six (1b, 4b-8b) showed NO inhibition with no or weak cytotoxicity (CC50  > 100 μM), especially 4b, and showed an IC50 value of 2.67 μM. Enzyme activity and docking assay revealed that the six compounds, especially 4b, target inducible NO synthase (iNOS) and exhibit potent inhibitory effects on iNOS with IC50 values ranging from 1...
April 1, 2018: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29626523/expression-of-genes-in-primo-vasculature-floating-in-lymphatic-endothelium-under-lipopolysaccharide-and-acupuncture-electric-stimulation
#17
Jun-Young Shin, Jong-Ok Ji, Da-Woon Choi, Sang-Heon Choi, Jong-Gu Choi, Min-Suk Rho, Ji Yoon Lee, Sang-Suk Lee
It is known that the existence of primo vascular system (PVS) including the primo nodes and vessels. However, it is poorly understood the relevant genes in the PVS system both patho- and physiologic condition. Here, we first examined the gene expression in primo vessels (PV) floating in lymphatic endothelium by isolation of PVS and lymphatic vessels (LV) containing PVS. To investigate therapeutic effects, both PV and LV containing PVS were isolated after lipopolysaccharides (LPS) injection and acupuncture electric stimulation (AES) at two acupoints of Joksamni (ST36) and Hapgok (LI04) following LPS...
April 4, 2018: Journal of Acupuncture and Meridian Studies
https://www.readbyqxmd.com/read/29620229/mir%C3%A2-22%C3%A2-3p-enhances-multi%C3%A2-chemoresistance-by-targeting-net1-in-bladder-cancer-cells
#18
Jun Xiao, Sanqiang Niu, Jiahong Zhu, Lei Lv, Hui Deng, Daqing Pan, Deyun Shen, Congyun Xu, Zhou Shen, Tao Tao
With the discovery of new chemotherapeutic drugs, chemotherapy becomes increasingly valuable. However, the resistance of tumor cells to chemotherapeutic agents significantly limits the effectiveness and causes chemotherapy failure. MicroRNAs have been shown to regulate drug resistance in many types of cancer. In the present study, we measured the chemosensitivity of five bladder cancer (BCa) cell lines to seven commonly used chemotherapeutic drugs by Vita‑Blue assay. We then identified the most sensitive (5637) and most tolerant cell lines (H‑bc) and conducted a multi‑group test...
April 4, 2018: Oncology Reports
https://www.readbyqxmd.com/read/29619862/characteristics-of-patients-with-coexisting-iga-nephropathy-and-membranous-nephropathy
#19
Pei Chen, Su-Fang Shi, Zhen Qu, Na Zhao, Xin-Fang Xie, Ji-Cheng Lv, Li-Jun Liu, Hong Zhang
BACKGROUND: Coexistence of IgA nephropathy (IgAN) and membranous nephropathy (MN) in the same patient is rare. Few studies have reported the clinical and pathological features of patients with combined IgAN and MN (IgAN-MN). METHODS: The clinico-pathological features, levels of galactose-deficient IgA1 (Gd-IgA1) and autoantibodies against M-type transmembrane phospholipase A2 receptor (anti-PLA2 R) in sera were compared among IgAN-MN, IgAN, and MN patients. RESULTS: Twenty-six patients with biopsy-proven IgAN-MN were enrolled...
November 2018: Renal Failure
https://www.readbyqxmd.com/read/29615110/gut-dependent-microbial-translocation-induces-inflammation-and-cardiovascular-events-after-st-elevation-myocardial-infarction
#20
Xin Zhou, Jing Li, Junli Guo, Bin Geng, Wenjie Ji, Qian Zhao, Jinlong Li, Xinlin Liu, Junxiang Liu, Zhaozeng Guo, Wei Cai, Yongqiang Ma, Dong Ren, Jun Miao, Shaobo Chen, Zhuoli Zhang, Junru Chen, Jiuchang Zhong, Wenbin Liu, Minghui Zou, Yuming Li, Jun Cai
BACKGROUND: Post-infarction cardiovascular remodeling and heart failure are the leading cause of myocardial infarction (MI)-driven death during the past decades. Experimental observations have involved intestinal microbiota in the susceptibility to MI in mice; however, in humans, identifying whether translocation of gut bacteria to systemic circulation contributes to cardiovascular events post-MI remains a major challenge. RESULTS: Here, we carried out a metagenomic analysis to characterize the systemic bacteria in a cohort of 49 healthy control individuals, 50 stable coronary heart disease (CHD) subjects, and 100 ST-segment elevation myocardial infarction (STEMI) patients...
April 3, 2018: Microbiome
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