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Jun Lv

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https://www.readbyqxmd.com/read/29224124/underestimated-effects-of-sediments-on-enhanced-startup-performance-of-biofilm-systems-for-polluted-source-water-pretreatment
#1
Zheng-Hui Lv, Jing Wang, Guang-Feng Yang, Li-Juan Feng, Jun Mu, Liang Zhu, Xiang-Yang Xu
In order to evaluate the enhancement mechanisms of enhanced startup performance in biofilm systems for polluted source water pretreatment, three lab-scale reactors with elastic stereo media (ESM) were operated under different enhanced sediment and hydraulic agitation conditions. It is interesting to found the previously underestimated or overlooked effects of sediment on the enhancement of pollutants removal performance and enrichment of functional bacteria in biofilm systems. The maximum NH4+-N removal rate of 0...
December 9, 2017: Biodegradation
https://www.readbyqxmd.com/read/29221728/emulsified-isoflurane-induces-release-of-cytochrome-c-in-human-neuroblastoma-shsy-5y-cells-via-jnk-c-jun-n-terminal-kinases-signaling-pathway
#2
Zeyong Yang, Jingjing Lv, Xianfu Lu, Xingxing Li, Xiaohu An, Jianwei Wang, Hao Weng, Yuanhai Li
A large number of studies have demonstrated that inhalation anesthetic isoflurane induced neural cell death by apoptosis in various cell and animal models. Emulsified isoflurane (EIso) is a new type of intravenous preparation of isoflurane that attracts increasing research attention as a promising clinical agent due to its both advantages as an intravenous and inhalation anesthetics medication. However, its safety and underlying molecular mechanism of neurotoxicity largely remain unknown. Therefore, it is meaningful to investigate the safety of EIso and to further elucidate its mechanism of anesthetic neurotoxicity...
December 5, 2017: Neurotoxicology and Teratology
https://www.readbyqxmd.com/read/29221438/double-catheter-lavage-combined-with-percutaneous-flexible-endoscopic-debridement-for-infected-pancreatic-necrosis-failed-to-percutaneous-catheter-drainage
#3
Pi Liu, Jun Song, Hua-Jing Ke, Nong-Hua Lv, Yin Zhu, Hao Zeng, Yong Zhu, Liang Xia, Wen-Hua He, Ji Li, Xin Huang, Yu-Peng Lei
BACKGROUND: Infected pancreatic necrosis (IPN) is a serious local complication of acute pancreatitis, with high mortality. Minimally invasive therapy including percutaneous catheter drainage (PCD) has become the preferred method for IPN instead of traditional open necrosectomy. However, the efficacy of double-catheter lavage in combination with percutaneous flexible endoscopic debridement after PCD failure is unknown compared with surgical necrosectomy. METHODS: A total of 27 cases of IPN patients with failure PCD between Jan 2014 and Dec 2015 were enrolled in this retrospective cohort study...
December 8, 2017: BMC Gastroenterology
https://www.readbyqxmd.com/read/29218953/-exploiture-and-application-of-an-internet-based-computation-platform-for-integrative-pharmacology-of-traditional-chinese-medicine
#4
Hai-Yu Xu, Zhen-Ming Liu, Yan Fu, Yan-Qiong Zhang, Jian-Jun Yu, Fei-Fei Guo, Shi-Huan Tang, Chuan-Yu Lv, Jin Su, Ru-Yi Cui, Hong-Jun Yang
Recently, integrative pharmacology(IP) has become a pivotal paradigm for the modernization of traditional Chinese medicines(TCM) and combinatorial drugs discovery, which is an interdisciplinary science for establishing the in vitro and in vivo correlation between absorption, distribution, metabolism, and excretion/pharmacokinetic(ADME/PK) profiles of TCM and the molecular networks of disease by the integration of the knowledge of multi-disciplinary and multi-stages. In the present study, an internet-based Computation Platform for IP of TCM(TCM-IP, www...
September 2017: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/29212180/padi4-rs2240337-g-a-polymorphism-is-associated-with-susceptibility-of-esophageal-squamous-cell-carcinoma-in-a-chinese-population
#5
Liming Wang, Haiyong Gu, Tao Long, Huiwen Pan, Lu Lv, Yijun Shi, Jingfeng Zhu, Yangyong Sun, Weifeng Tang, Guowen Ding, Suocheng Chen, Yu Fan, Hao Ding, Cheng Qian, Qun Wang, Jun Yao, Lijie Tan, Jun Yin
Background: Esophageal cancer (EC) remains one of the major causes of cancer incidence and mortality worldwide. Genetic factors, such as single nucleotide polymorphisms (SNPs), may contribute to the carcinogenesis of EC. Methods: We conducted a hospital based case-control study to evaluate the genetic susceptibility of SNPs on the development of EC. A total of 629 esophageal squamous cell carcinoma (ESCC) cases and 686 controls were enrolled for this study. Seven PADI4 SNPs were determined by ligation detection reaction method...
November 7, 2017: Oncotarget
https://www.readbyqxmd.com/read/29210521/regulatory-efficacy-of-brown-seaweed-lessonia-nigrescens-extract-on-the-gene-expression-profile-and-intestinal-microflora-in-type-2-diabetic-mice
#6
Chao Zhao, Chengfeng Yang, Mingjun Chen, Xucong Lv, Bin Liu, Lunzhao Yi, Laura Cornara, Ming-Chi Wei, Yu-Chiao Yang, Rosa Tundis, Jianbo Xiao
SCOPE: In this study, the antidiabetic activity of Lessonia nigrescens ethanolic extract (LNE) was investigated in streptozotocin (SZT)-induced type 2 diabetic mice fed with a high-sucrose/high-fat diet. METHODS AND RESULTS: The ultra-high performance liquid chromatography coupled with photo-diode array detector and electrospray ionization-mass spectrometry was employed to analyze the major compounds in LNE. The components of the intestinal microflora in type 2 diabetic mice were analyzed by high-throughput next-generation 16S rRNA gene sequencing...
December 6, 2017: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/29208736/pathophysiological-and-behavioral-deficits-in-developing-mice-following-rotational-acceleration-deceleration-traumatic-brain-injury
#7
Guoxiang Wang, Yi Ping Zhang, Zhongwen Gao, Lisa B E Shields, Fang Li, Tianci Chu, Huayi Lv, Thomas Moriarty, Xiao-Ming Xu, Xiaoyu Yang, Christopher B Shields, Jun Cai
Abusive head trauma (AHT) is the leading cause of death from trauma in infants and young children. An AHT animal model was developed on 12-day-old mice subjected to 90° head extension-flexion sagittal shaking repeated 30, 60, 80, and 100 times. The mortality and time until return of consciousness were dependent on the number of repeats and severity of the injury. Under 60 times of repeated head shakings, the pups demonstrated apnea and/or bradycardia immediately after injury. Acute oxygen desaturation was observed by pulse oximetry during respiratory and cardiac suppression...
November 30, 2017: Disease Models & Mechanisms
https://www.readbyqxmd.com/read/29204757/prevalence-of-comorbidities-and-evaluation-of-screening-in-chinese-patients-with-spondyloarthritis
#8
Yutong Jiang, Pingping Zhang, Liudan Tu, Qing Lv, Jun Qi, Zhiming Lin, Zetao Liao, Shuangyan Cao, Jieruo Gu
The aim of the study was to determine whether the presence of spondyloarthritis (SpA) is associated with particular comorbidities and evaluate the prevalence of comorbidities, risk factors, and monitoring status in China. Three hundred forty-six patients fulfilling ASAS criteria for SpA were recruited from the Third Affiliated Hospital of Sun Yat-sen University. The prevalence of comorbidities and percentage of patients optimally monitored for comorbidities were calculated. The most frequent comorbidities were osteoporosis (31...
December 4, 2017: Clinical Rheumatology
https://www.readbyqxmd.com/read/29203491/chemogenomic-profiling-of-the-fungal-pathogen-candida-albicans
#9
Yaolin Chen, Jaideep Mallick, Alaa Maqnas, Yuan Sun, Baharul I Choudhury, Pierre Cote, Lan Yan, Ting-Jun-Hong Ni, Yan Li, Dazhi Zhang, Roberto Rodríguez-Ortiz, Quan-Zhen Lv, Yuan-Ying Jiang, Malcolm Whiteway
There are currently a small number of classes of antifungal drugs, and these drugs are known to target a very limited set of cellular functions. We derived a set of approximately 900 non-essential, transactivator-defective disruption strains from the tetracycline regulated GRACE strain collection of the fungal pathogen Candida albicans This strain set was screened against classic antifungal drugs to identify gene inactivations that conferred either enhanced sensitivity or increased resistance to the compounds...
December 4, 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/29200200/wogonin-protects-against-cisplatin-induced-acute-kidney-injury-by-targeting-ripk1-mediated-necroptosis
#10
Xiao-Ming Meng, Hai-Di Li, Wei-Feng Wu, Patrick Ming-Kuen Tang, Gui-Ling Ren, Li Gao, Xiao-Feng Li, Yang Yang, Tao Xu, Tao-Tao Ma, Zeng Li, Cheng Huang, Lei Zhang, Xiong-Wen Lv, Jun Li
Acute kidney injury (AKI), characterized by aggressive inflammatory responses and destruction of renal resident cells, can cause abrupt kidney dysfunction. To date, effective therapy for AKI is lacking. In this study, we evaluated the renoprotective effect of wogonin, an herbal active compound, using a cisplatin-induced AKI mouse model. In vivo results show that wogonin substantially suppressed the increased levels of serum creatinine and blood urea nitrogen (BUN) almost to the normal level. Wogonin also attenuated tubular damage, shown by PAS staining, electron microscopy and molecular analysis of KIM-1...
December 4, 2017: Laboratory Investigation; a Journal of Technical Methods and Pathology
https://www.readbyqxmd.com/read/29199038/association-of-interleukin-10-gene-single-nucleotide-polymorphisms-with-susceptibility-to-systemic-lupus-erythematosus-in-a-chinese-population
#11
Tian-Tian Lv, Jun Wu, Jun Li, Tian-Ping Zhang, Xiao-Ke Yang, Nan Xiang, Yin-Guang Fan, Hai-Feng Pan, Bin Wang
The aim of this study was to investigate the association of interleukin (IL)-10 gene single nucleotide polymorphisms (SNPs) with susceptibility to systemic lupus erythematosus (SLE) in a Chinese population. 848 SLE patients and 461 normal controls were recruited in this study. Nine SNPs in IL-10 gene (rs1518110, rs1518111, rs1554286, rs1800890, rs1800893, rs3024493, rs3024495, rs3024498 and rs6667202) were genotyped using TaqMan genotyping assays on Fluidigm 192.24 system. The frequency of IL-10 rs3024498-C allele was significantly higher in patient group compared with control subjects (OR=5...
November 30, 2017: Gene
https://www.readbyqxmd.com/read/29195333/synchronization-stability-and-pattern-selection-in-a-memristive-neuronal-network
#12
Chunni Wang, Mi Lv, Ahmed Alsaedi, Jun Ma
Spatial pattern formation and selection depend on the intrinsic self-organization and cooperation between nodes in spatiotemporal systems. Based on a memory neuron model, a regular network with electromagnetic induction is proposed to investigate the synchronization and pattern selection. In our model, the memristor is used to bridge the coupling between the magnetic flux and the membrane potential, and the induction current results from the time-varying electromagnetic field contributed by the exchange of ion currents and the distribution of charged ions...
November 2017: Chaos
https://www.readbyqxmd.com/read/29192211/nematic-superconducting-state-in-iron-pnictide-superconductors
#13
Jun Li, Paulo J Pereira, Jie Yuan, Yang-Yang Lv, Mei-Ping Jiang, Dachuan Lu, Zi-Quan Lin, Yong-Jie Liu, Jun-Feng Wang, Liang Li, Xiaoxing Ke, Gustaaf Van Tendeloo, Meng-Yue Li, Hai-Luke Feng, Takeshi Hatano, Hua-Bing Wang, Pei-Heng Wu, Kazunari Yamaura, Eiji Takayama-Muromachi, Johan Vanacken, Liviu F Chibotaru, Victor V Moshchalkov
Nematic order often breaks the tetragonal symmetry of iron-based superconductors. It arises from regular structural transition or electronic instability in the normal phase. Here, we report the observation of a nematic superconducting state, by measuring the angular dependence of the in-plane and out-of-plane magnetoresistivity of Ba0.5K0.5Fe2As2 single crystals. We find large twofold oscillations in the vicinity of the superconducting transition, when the direction of applied magnetic field is rotated within the basal plane...
December 1, 2017: Nature Communications
https://www.readbyqxmd.com/read/29192208/endogenous-annexin-a1-regulates-haematopoietic-stem-cell-mobilisation-and-inflammatory-response-post-myocardial-infarction-in-mice-in-vivo
#14
Cheng Xue Qin, Siobhan B Finlayson, Annas Ai-Sharea, Mitchel Tate, Miles J De Blasio, Minh Deo, Sarah Rosli, Darnel Prakoso, Colleen J Thomas, Helen Kiriazis, Eleanor Gould, Yuan H Yang, Eric F Morand, Mauro Perretti, Andrew J Murphy, Xiao-Jun Du, Xiao-Ming Gao, Rebecca H Ritchie
Endogenous anti-inflammatory annexin-A1 (ANX-A1) plays an important role in preserving left ventricular (LV) viability and function after ischaemic insults in vitro, but its long-term cardioprotective actions in vivo are largely unknown. We tested the hypothesis that ANX-A1-deficiency exaggerates inflammation, haematopoietic stem progenitor cell (HSPC) activity and LV remodelling in response to myocardial ischaemia in vivo. Adult ANX - A1 -/- mice subjected to coronary artery occlusion exhibited increased infarct size and LV macrophage content after 24-48 h reperfusion compared with wildtype (WT) counterparts...
November 30, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29183566/application-of-pressure-derived-myocardial-fractional-flow-reserve-in-chronic-hemodialysis-patients
#15
Kimihiko Hirose, Taishiro Chikamori, Satoshi Hida, Nobuhiro Tanaka, Jun Yamashita, Yuko Igarashi, Tetsushi Saitoh, Hirokazu Tanaka, Akira Yamashina
BACKGROUND: Although fractional flow reserve (FFR) measurements during coronary angiography are performed in routine clinical practice, few studies have evaluated FFR measurements in dialysis patients. METHODS: We retrospectively studied 42 hemodialysis patients with suspected or known coronary artery disease (CAD) who underwent stress myocardial perfusion imaging and coronary angiography with FFR measurements for 61 coronary lesions. The cut-off value for FFR to detect myocardial ischemia was determined by receiver operating characteristic (ROC) curve analysis...
January 2018: Journal of Cardiology
https://www.readbyqxmd.com/read/29180881/curcumin-potentiates-the-potent-antitumor-activity-of-acnu-against-glioblastoma-by-suppressing-the-pi3k-akt-and-nf-%C3%AE%C2%BAb-cox-2-signaling-pathways
#16
Jun Zhao, Jiabin Zhu, Xiaoshu Lv, Jinshan Xing, Shuang Liu, Chen Chen, Yinghui Xu
Glioblastoma (GBM) is a highly invasive and challenging primary tumor of the central nervous system (CNS), and currently available treatments provide limited benefits to patients with this disease. Therefore, the development of novel therapeutic targets and effective treatment strategies is essential. Nimustine hydrochloride (ACNU) is widely used as the standard chemotherapeutic agent and is frequently administered together with other chemotherapeutic agents in clinical studies. Curcumin, a natural polyphenolic compound, could potentially be combined with chemotherapeutics for cancer treatment; however, there are no reports of studies where ACNU and curcumin were combined for GBM treatment, and the mechanisms underlying their activity remain poorly understood...
2017: OncoTargets and Therapy
https://www.readbyqxmd.com/read/29179951/ros-dependent-atg4-upregulation-mediated-autophagy-plays-an-important-role-in-cd-induced-proliferation-and-invasion-in-a549-cells
#17
Wei Lv, Linlin Sui, Xiaona Yan, Huaying Xie, Liping Jiang, Chengyan Geng, Qiujuan Li, Xiaofeng Yao, Ying Kong, Jun Cao
Cadmium (Cd) is a toxic heavy metal that is widely used in industry and agriculture. In this study the role of autophagy in Cd-induced proliferation, migration and invasion was investigated in A549 cells. Exposure to Cd (2 μM) significantly increased reactive oxygen species (ROS) production, induced autophagy and enhanced cell growth, migration and invasion in A549 cells. Western blot analysis showed that the expression of autophagy-related proteins, LC3-II, Beclin-1 and Atg4 and invasion-related protein MMP-9 were upregulated in Cd-treated cells...
November 24, 2017: Chemico-biological Interactions
https://www.readbyqxmd.com/read/29179675/cgl2-plays-an-essential-role-in-cuticular-wax-biosynthesis-in-cabbage-brassica-oleracea-l-var-capitata
#18
Dongming Liu, Jun Tang, Zezhou Liu, Xin Dong, Mu Zhuang, Yangyong Zhang, Honghao Lv, Peitian Sun, Yumei Liu, Zhansheng Li, Zhibiao Ye, Zhiyuan Fang, Limei Yang
BACKGROUND: The aerial parts of most land plants are covered with cuticular wax which is important for plants to avoid harmful factors. There is still no cloning study about wax synthesis gene of the alcohol-forming pathway in Brassica species. RESULTS: Scanning electron microscopy (SEM) showed that, compared with wild type (WT), wax crystal are severely reduced in both the adaxial and abaxial sides of cabbage (Brassica oleracea L. var. capitata L.) leaves from the LD10GL mutant...
November 28, 2017: BMC Plant Biology
https://www.readbyqxmd.com/read/29179484/association-of-circulating-branched-chain-amino-acids-with-cardiometabolic-traits-differs-between-adults-and-the-oldest-old
#19
Liang Sun, Caiyou Hu, Ruiyue Yang, Yuan Lv, Huiping Yuan, Qinghua Liang, Benjin He, Guofang Pang, Menghua Jiang, Jun Dong, Ze Yang
Branched-chain amino acids (BCAAs) are promising for their potential anti-aging effects. However, findings in adults suggest that circulating BCAAs are associated with cardiometabolic risk. Moreover, little information is available about how BCAAs influence clustered cardiometabolic traits in the oldest-old (>85 years), which are the fastest-growing segment of the population in developed countries. Here, we applied a targeted metabolomics approach to measure serum BCAAs in Chinese participants (aged 21-110 years) based on a longevity cohort...
October 24, 2017: Oncotarget
https://www.readbyqxmd.com/read/29177574/prevalence-of-psychological-disorders-sleep-disturbance-and-stressful-life-events-and-their-relationships-with-disease-parameters-in-chinese-patients-with-ankylosing-spondylitis
#20
Yutong Jiang, Mingcan Yang, Qing Lv, Jun Qi, Zhiming Lin, Zetao Liao, Yanli Zhang, Husheng Wu, Hui Song, Feng Zhan, Shengyun Liu, Guanmin Gao, Shaoxian Hu, Yinong Li, Lingxun Shen, Anbing Huang, Qiujing Wei, Shuangyan Cao, Jieruo Gu
Our aim was to investigate the prevalence of psychological disorders, sleep disturbance, and stressful life events in Chinese patients with ankylosing spondylitis (AS) and healthy controls, to assess the correlation between psychological and disease-related variables, and finally to detect powerful factors in predicting anxiety and depression. AS patients diagnosed with the modified New York criteria and healthy controls were enrolled from China. Participants completed a set of questionnaires, including demographic and disease parameters, Zung self-rating anxiety scale (SAS), Zung self-rating depression scale (SDS), the Pittsburgh Sleep Quality Index questionnaire (PSQI), and the Social Readjustment Rating Scale (SRRS)...
November 25, 2017: Clinical Rheumatology
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