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https://www.readbyqxmd.com/read/28077466/tea-consumption-and-risk-of-ischaemic-heart-disease
#1
Xia Li, Canqing Yu, Yu Guo, Zheng Bian, Jiahui Si, Ling Yang, Yiping Chen, Xiaolan Ren, Ge Jiang, Junshi Chen, Zhengming Chen, Jun Lv, Liming Li
OBJECTIVE: To prospectively examine the association between tea consumption and the risk of ischaemic heart disease (IHD). METHODS: Prospective study using the China Kadoorie Biobank; participants from 10 areas across China were enrolled during 2004-2008 and followed up until 31 December 2013. After excluding participants with cancer, heart disease and stroke at baseline, the present study included 199 293 men and 288 082 women aged 30-79 years at baseline...
January 11, 2017: Heart: Official Journal of the British Cardiac Society
https://www.readbyqxmd.com/read/28075465/monoclonal-antibody-zt-g4-targeting-ron-receptor-tyrosine-kinase-enhances-chemosensitivity-of-bladder-cancer-cells-to-epirubicin-by-promoting-g1-s-arrest-and-apoptosis
#2
Jun-Feng Chen, Bi-Xia Yu, Rui Yu, Liang Ma, Xiu-Yi Lv, Yue Cheng, Qi Ma
Epirubicin (EPI) is one of the most used intravesical chemotherapy agents after transurethral resection to non-muscle invasive bladder tumors (NMIBC) to prevent cancer recurrence and progression. However, even after resection of bladder tumors and intravesical chemotherapy, half of them will recur and progress. RON is a membrane tyrosine kinase receptor usually overexpressed in bladder cancer cells and associated with poor pathological features. This study aims to investigate the effects of anti-RON monoclonal antibody Zt/g4 on the chemosensitivity of bladder cells to EPI...
January 5, 2017: Oncology Reports
https://www.readbyqxmd.com/read/28073832/reperfusion-therapy-with-recombinant-human-relaxin-2-serelaxin-attenuates-myocardial-infarct-size-and-nlrp3-inflammasome-following-ischemia-reperfusion-injury-via-enos-dependent-mechanism
#3
Juan Valle Raleigh, Adolfo G Mauro, Teja Devarakonda, Carlo Marchetti, Jun He, Erica Kim, Scott Filippone, Anindita Das, Stefano Toldo, Antonio Abbate, Fadi N Salloum
AIMS: The preconditioning-like infarct-sparing and anti-inflammatory effects of the peptide hormone relaxin following ischemic injury have been studied in the heart. Whether reperfusion therapy with recombinant human relaxin-2, serelaxin, reduces myocardial infarct size and attenuates the subsequent NLRP3 inflammasome activation leading to further loss of functional myocardium following ischemia/reperfusion (I/R) injury is unknown. METHODS AND RESULTS: After baseline echocardiography, adult male wild-type C57BL or eNOS knockout mice underwent myocardial infarction (MI) by coronary artery ligation for 30 min followed by 24 h reperfusion...
January 10, 2017: Cardiovascular Research
https://www.readbyqxmd.com/read/28068219/hyphobacterium-vulgare-gen-nov-sp-nov-a-novel-alpha-proteobacterium-isolated-from-seawater-in-the-south-china-sea
#4
Cong Sun, Rui-Jun Wang, Yue Su, Ge-Yi Fu, Zhe Zhao, Xiao-Yun Yu, Chong-Ya Zhang, Can Chen, Shuai-Bo Han, Meng-Meng Huang, Zheng-Bing Lv, Min Wu
A Gram-staining-negative, aerobic, non-spore-forming, non-motile, oval to rod shaped bacteria with prosthecate, designated as WM6T, was isolated from seawater sample collected from the South China Sea at depth of 150 meter and subjected to a polyphasic taxonomic investigation. Cells of strain WM6T were approximately 0.5-0.6 μm in width and 0.8-1.2 μm in length, and colonies of strain WM6T were smooth, circular, convex and whity-yellow. Strain WM6T was found to grow at 10-45 °C (optimum, 30 °C), pH 6.5-9...
January 6, 2017: International Journal of Systematic and Evolutionary Microbiology
https://www.readbyqxmd.com/read/28064359/season-of-birth-and-the-risk-of-type-2-diabetes-in-adulthood-a-prospective-cohort-study-of-0-5-million-chinese-adults
#5
Jiahui Si, Canqing Yu, Yu Guo, Zheng Bian, Xia Li, Ling Yang, Yiping Chen, Huarong Sun, Bo Yu, Junshi Chen, Zhengming Chen, Jun Lv, Liming Li
AIMS/HYPOTHESIS: Season of birth as a surrogate for potential environmental exposure during fetal development and early postnatal life has shown an inconsistent association with adult type 2 diabetes in white populations living in high-latitude regions. The present study aimed to examine the association between birth seasonality and risk of adult type 2 diabetes in Chinese individuals living across wide regions of low latitude and lower to middle latitude. METHODS: Participants from the China Kadoorie Biobank were enrolled during 2004-2008 and followed up until 31 December 2013...
January 7, 2017: Diabetologia
https://www.readbyqxmd.com/read/28063782/acceptable-clinical-outcomes-and-recommended-reconstructive-strategies-for-secondary-maxillary-reconstruction-with-vascularized-fibula-osteomyocutaneous-flap-a-retrospective-analysis
#6
Yi Shen, Jun Li, Andrew Ow, Liang Wang, Ming-Ming Lv, Jian Sun
BACKGROUND: We conducted a retrospective analysis of the clinical outcomes and evaluated the reconstructive strategies in patients who underwent secondary maxillary reconstruction with a vascularized fibula osteomyocutaneous flap (VFOF). METHODS: From May of 2001 to June of 2014, 34 patients who underwent secondary maxillary reconstruction with VFOF, with or without titanium mesh, were reviewed. The patients were divided into two groups of maxillary reconstruction, according to different planning and treatment strategies...
December 14, 2016: Journal of Plastic, Reconstructive & Aesthetic Surgery: JPRAS
https://www.readbyqxmd.com/read/28063165/diabetes-plasma-glucose-and-incidence-of-pancreatic-cancer-a-prospective-study-of-0-5-million-chinese-adults-and-a-meta-analysis-of-22-cohort-studies
#7
Yuanjie Pang, Christiana Kartsonaki, Yu Guo, Fiona Bragg, Ling Yang, Zheng Bian, Yiping Chen, Andri Iona, Iona Y Millwood, Jun Lv, Canqing Yu, Junshi Chen, Liming Li, Michael V Holmes, Zhengming Chen
Diabetes is associated with an increased risk of pancreatic cancer (PC) in Western populations. Uncertainty remains, however, about the relevance of plasma glucose for PC among people without diabetes and about the associations of diabetes and high blood glucose with PC in China where the increase in diabetes prevalence has been very recent. The prospective China Kadoorie Biobank (CKB) study recruited 512,000 adults aged 30-79 years from 10 diverse areas of China during 2004-08, recording 595 PC cases during 8 years of follow-up...
January 7, 2017: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/28060733/high-expression-of-mir-105-1-positively-correlates-with-clinical-prognosis-of-hepatocellular-carcinoma-by-targeting-oncogene-ncoa1
#8
Yu-Shui Ma, Ting-Miao Wu, Zhong-Wei Lv, Gai-Xia Lu, Xian-Ling Cong, Ru-Ting Xie, Hui-Qiong Yang, Zheng-Yan Chang, Ran Sun, Li Chai, Ming-Xiang Cai, Xiao-Jun Zhong, Jian Zhu, Da Fu
Increasing evidence supports that microRNA (miRNA) plays a significant functional role in cancer progression by directly regulating respective targets. In this study, the expression levels of miR-105-1 and its target gene were analyzed using genes microarray and hierarchical clustering analysis followed by validation with quantitative RT-PCR in hepatocellular carcinoma (HCC) and normal liver tissues. We examined the expression of nuclear receptor coactivator 1 (NCOA1), the potential target gene of miR-105-1, following the transfection of miR-105-1 mimics or inhibitors...
January 2, 2017: Oncotarget
https://www.readbyqxmd.com/read/28059466/validation-of-clinic-weights-from-electronic-health-records-against-standardized-weight-measurements-in-weight-loss-trials
#9
Lan Xiao, Nan Lv, Lisa G Rosas, David Au, Jun Ma
OBJECTIVE: To validate clinic weights in electronic health records against researcher-measured weights for outcome assessment in weight loss trials. METHODS: Clinic and researcher-measured weights from a published trial (BE WELL) were compared using Lin's concordance correlation coefficient, Bland and Altman's limits of agreement, and polynomial regression model. Changes in clinic and researcher-measured weights in BE WELL and another trial, E-LITE, were analyzed using growth curve modeling...
January 6, 2017: Obesity
https://www.readbyqxmd.com/read/28058571/predictable-weathering-of-puparial-hydrocarbons-of-necrophagous-flies-for-determining-the-postmortem-interval-a-field-experiment-using-chrysomya-rufifacies
#10
Guang-Hui Zhu, Zheng-Jun Jia, Xiao-Jun Yu, Ku-Sheng Wu, Lu-Shi Chen, Jun-Yao Lv, M Eric Benbow
Preadult development of necrophagous flies is commonly recognized as an accurate method for estimating the minimum postmortem interval (PMImin). However, once the PMImin exceeds the duration of preadult development, the method is less accurate. Recently, fly puparial hydrocarbons were found to significantly change with weathering time in the field, indicating their potential use for PMImin estimates. However, additional studies are required to demonstrate how the weathering varies among species. In this study, the puparia of Chrysomya rufifacies were placed in the field to experience natural weathering to characterize hydrocarbon composition change over time...
January 5, 2017: International Journal of Legal Medicine
https://www.readbyqxmd.com/read/28056856/potential-unfavorable-impacts-of-bdnf-val66met-polymorphisms-on-metabolic-risks-in-average-population-in-a-longevous-area
#11
Jun-Hua Peng, Cheng-Wu Liu, Shang-Ling Pan, Hua-Yu Wu, Qing-Hua Liang, Rui-Jing Gan, Ling Huang, Yi Ding, Zhang-Ya Bian, Hao Huang, Ze-Ping Lv, Xiao-Ling Zhou, Rui-Xing Yin
BACKGROUND: Brain-derived neurotrophic factor (BDNF) has been implicated in cognitive performance and the modulation of several metabolic parameters in some disease models, but its potential roles in successful aging remain unclear. We herein sought to define the putative correlation between BDNF Val66Met and several metabolic risk factors including BMI, blood pressure, fasting plasma glucose (FPG) and lipid levels in a long-lived population inhabiting Hongshui River Basin in Guangxi...
January 5, 2017: BMC Geriatrics
https://www.readbyqxmd.com/read/28053087/targeting-traf3ip2-by-genetic-and-interventional-approaches-inhibits-ischemia-reperfusion-induced-myocardial-injury-and-adverse-remodeling
#12
John M Erikson, Anthony J Valente, Srinivas Mummidi, Hemanthkumar Kandikattu, Vincent G DeMarco, Shawn B Bender, William P Fay, Ulrich Siebenlist, Bysani Chandrasekar
Re-establishing blood supply is the primary goal for reducing myocardial injury in subjects with ischemic heart disease. Paradoxically, reperfusion results in oxidative stress and a marked inflammatory response in the heart. TRAF3IP2 (TRAF3 Interacting Protein 2; previously known as CIKS or Act1) is an oxidative stress-responsive cytoplasmic adapter molecule that is an upstream regulator of both IκB kinase (IKK) and c-Jun N-terminal kinase (JNK), and an important mediator of autoimmune and inflammatory responses...
January 4, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28049027/an-integrated-shotgun-proteomics-and-bioinformatics-approach-for-analysis-of-brain-proteins-from-mcao-model-using-serial-affinity-chromatograph-with-four-active-ingredients-from-shengmai-preparations-as-ligands
#13
Xiao-Xue Fan, Fang Li, Yan-Ni Lv, Yu Zhang, Jun-Ping Kou, Bo-Yang Yu
Identification and validation of disease-relevant target proteins for natural products is an essential component of modern pharmaceutical research. In the present study, an integrated shotgun proteomics and bioinformatics approach was established to profile the interaction of active small molecules derived from ShengMai preparations (SMXZF) with hundreds of endogenously expressed proteins from middle cerebral artery occlusion (MCAO) model. Affinity-based proteomic strategies for isolation and identification of targets for the bioactive components is a classic, but still powerful approach...
January 1, 2017: Neurochemistry International
https://www.readbyqxmd.com/read/28042342/the-landscape-of-clinical-trials-evaluating-the-theranostic-role-of-pet-imaging-in-oncology-insights-from-an-analysis-of-clinicaltrials-gov-database
#14
Yu-Pei Chen, Jia-Wei Lv, Xu Liu, Yuan Zhang, Ying Guo, Ai-Hua Lin, Ying Sun, Yan-Ping Mao, Jun Ma
In the war on cancer marked by personalized medicine, positron emission tomography (PET)-based theranostic strategy is playing an increasingly important role. Well-designed clinical trials are of great significance for validating the PET applications and ensuring evidence-based cancer care. This study aimed to provide a comprehensive landscape of the characteristics of PET clinical trials using the substantial resource of ClinicalTrials.gov database. We identified 25,599 oncology trials registered with ClinicalTrials...
2017: Theranostics
https://www.readbyqxmd.com/read/28041914/repression-of-tsc1-tsc2-mediated-by-mecp2-regulates-human-embryo-lung-fibroblast-cell-differentiation-and-proliferation
#15
Yuanyuan Wang, Chen Chen, Ziyu Deng, Erbao Bian, Cheng Huang, Ting Lei, Xiongwen Lv, Liping Liu, Jun Li
Pulmonary fibrosis (PF) is a severe inflammatory disease with limited effective treatments. It is known that the transdifferentiation of human embryo lung fibroblast (HELF) cells from pulmonary fibroblasts into myofibroblasts, contributes to the progression of pulmonary fibrogenesis. The tuberous sclerosis proteins TSC1 and TSC2 are two key signaling factors which can suppress cell growth and proliferation. However, the roles of TSC1 and TSC2 in lung fibroblast are unclear. Here, we developed a PF model with bleomycin (BLM) in mice and conducted several simulation experiments in HELF cells...
December 29, 2016: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28040403/effects-of-cerium-oxide-nanoparticles-on-the-species-and-distribution-of-phosphorus-in-enhanced-phosphorus-removal-sequencing-batch-biofilm-reactor
#16
Yi Xu, Chao Wang, Jun Hou, Peifang Wang, Guoxiang You, Lingzhan Miao, Bowen Lv, Yangyang Yang
The short term (8h) influences of cerium oxide nanoparticles (CeO2NPs) on the process of phosphorus removal in biofilm were investigated. At concentration of 0.1mg/L, CeO2 NPs posed no impacts on total phosphorus (TP) removal. While at 20mg/L, TP removal efficiency reduced from 85.16% to 59.62%. Results of P distribution analysis and (31)P nuclear magnetic resonance spectroscopy implied that the anaerobic degradation of polyphosphate (polyP) and the release of orthophosphate in extracellular polymeric substances (EPS) were inhibited...
March 2017: Bioresource Technology
https://www.readbyqxmd.com/read/28033289/liver-transplantation-versus-surgical-resection-for-hcc-meeting-the-milan-criteria-a-propensity-score-analysis
#17
Jun-Yi Shen, Chuan Li, Tian-Fu Wen, Lv-Nan Yan, Bo Li, Wen-Tao Wang, Jia-Yin Yang, Ming-Qing Xu, Tholakkara Nazar Highness
The optimal treatment (liver transplantation [LT] vs surgical resection [SR]) for early-stage hepatocellular carcinoma (HCC) remains controversial.A total of 209 SR patients and 129 LT patients were identified at our institution. After eliminating 27 patients with Child-Pugh C, the data from 209 SR patients and 102 LT patients were analyzed using a propensity score matching (PSM) model. Forty-six pairs were generated. A subgroup analysis was conducted based on the alpha-fetoprotein (AFP) level or platelet count (PLT)...
December 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28032546/alpha-fetoprotein-changes-predict-hepatocellular-carcinoma-survival-beyond-the-milan-criteria-after-hepatectomy
#18
Jun-Yi Shen, Chuan Li, Tian-Fu Wen, Lv-Nan Yan, Bo Li, Wen-Tao Wang, Jia-Yin Yang, Ming-Qing Xu
BACKGROUND: Assessing the outcomes of surgeries for hepatocellular carcinoma (HCC) patients who exceed the Milan criteria is necessary. Some studies have demonstrated that preoperative or postoperative alpha fetoprotein (AFP) can predict HCC patients' prognoses. METHODS: A total of 280 HCC patients who were positive for AFP and received curative resection were retrospectively analyzed. The patients were classified into three groups according to their preoperative and postoperative AFP levels (group A: normalized AFP; group B: AFP decreases >50%, but continued abnormality; and group C: AFP decreases <50%)...
October 14, 2016: Journal of Surgical Research
https://www.readbyqxmd.com/read/28032211/estimation-of-the-human-postmortem-interval-using-an-established-rat-mathematical-model-and-multi-rna-markers
#19
Ye-Hui Lv, Jian-Long Ma, Hui Pan, Yan Zeng, Li Tao, Heng Zhang, Wen-Can Li, Kai-Jun Ma, Long Chen
In our previous study, a R code-based mathematical model using RNA degradation patterns was developed for PMI determination in rat brain specimens. However, the postmortem changes of RNA are much more complicated in real cases, and there is still a huge challenge in efficiently applying information in animal data to real cases. In the present study, different RNA markers in both rat and human tissues were collected to screen valid biomarkers and the corresponding mathematical models were established and validated...
December 28, 2016: Forensic Science, Medicine, and Pathology
https://www.readbyqxmd.com/read/28025803/metabolic-transition-of-milk-lactose-synthesis-and-up-regulation-by-akt1-in-sows-from-late-pregnancy-to-lactation
#20
Fang Chen, Baoliang Chen, Wutai Guan, Jun Chen, Yantao Lv, Hanzhen Qiao, Chaoxian Wang, Yinzhi Zhang
Lactose plays a crucial role in controlling milk volume by inducing water toward into the mammary secretory vesicles from the mammary epithelial cell cytoplasm, thereby maintaining osmolality. In current study, we determined the expression of several lactose synthesis related genes, including glucose transporters (glucose transporter 1, glucose transporter 8, sodium-glucose cotransporter 1, sodium-glucose cotransporter 3, and sodium-glucose cotransporter 5), lactose synthases (α-lactalbumin and β1,4-galactosyltransferase), and hexokinases (hexokinase-1 and hexokinase-2) in sow mammary gland tissue at day 17 before delivery, on the 1st day of lactation and at peak lactation...
December 26, 2016: Cell Biochemistry and Biophysics
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