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Liming Li

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https://www.readbyqxmd.com/read/28932955/the-sustainable-arable-land-use-pattern-under-the-tradeoff-of-agricultural-production-economic-development-and-ecological-protection-an-analysis-of-dongting-lake-basin-china
#1
Guanyi Yin, Liming Liu, Xilong Jiang
To find a solution regarding sustainable arable land use pattern in the important grain-producing area during the rapid urbanization process, this study combined agricultural production, locational condition, and ecological protection to determine optimal arable land use. Dongting Lake basin, one of the major grain producing areas in China, was chosen as the study area. The analysis of land use transition, the calculation of arable land barycenter, the landscape indices of arable land patches, and the comprehensive evaluation of arable land quality(productivity, economic location, and ecological condition) were adopted in this study...
September 20, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28924102/microrna-483-5p-modulates-the-expression-of-cartilage-related-genes-in-human-chondrocytes-through-down-regulating-tgf-%C3%AE-1-expression
#2
Ronghua Xu, Jiayi Li, Bo Wei, Weiling Huo, Liming Wang
Transforming growth factor-β1 (TGF-β1) has been reported to improve chondrocytes phenotype and function. The expression levels of microRNA-483-5p (miR-483-5p), a potential regulator of TGF-β signaling pathway, were elevated in chondrocytes of patients with osteoarthritis. In this study, we aimed to explore the role of miR-483-5p for the expression of cartilage-related genes in chondrocytes. Human chondrocytes were harvested from femoral condyle and tibial plateau of different donors (n = 10) following amputation due to sarcomas not involving the joint space...
2017: Tohoku Journal of Experimental Medicine
https://www.readbyqxmd.com/read/28914755/thioredoxin-2-offers-protection-against-mitochondrial-oxidative-stress-in-h9c2-cells-and-against-myocardial-hypertrophy-induced-by-hyperglycemia
#3
Hong Li, Changqing Xu, Quanfeng Li, Xiuxiang Gao, Erkio Sugano, Hiroshi Tomita, Liming Yang, Sa Shi
Mitochondrial oxidative stress is thought to be a key contributor towards the development of diabetic cardiomyopathy. Thioredoxin 2 (Trx2) is a mitochondrial antioxidant that, along with Trx reductase 2 (TrxR2) and peroxiredoxin 3 (Prx3), scavenges H₂O₂ and offers protection against oxidative stress. Our previous study showed that TrxR inhibitors resulted in Trx2 oxidation and increased ROS emission from mitochondria. In the present study, we observed that TrxR inhibition also impaired the contractile function of isolated heart...
September 15, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28912269/glycoprotein-a-repetitions-predominant-garp-positively-regulates-transforming-growth-factor-tgf-%C3%AE-3-and-is-essential-for-mouse-palatogenesis
#4
Bill X Wu, Anqi Li, Liming Lei, Satoshi Kaneko, Caroline Wallace, Xue Li, Zihai Li
Glycoprotein A repetitions predominant (GARP) (encoded by the Lrrc32 gene) plays important roles in cell-surface docking and activation of TGF-beta. However, GARP role in organ development in mammalian system is unclear. To determine the function of GARP in vivo, we generated a GARP-KO mouse model. Unexpectedly, the GARP-KO mice died within 24 hours after birth and exhibited defective palatogenesis without apparent abnormalities in other major organs. Furthermore, we observed decreased apoptosis and SMAD2 phosphorylation in the medial edge epithelial (MEE) cells of the palatal shelf of GARP-KO embryos at day 14...
September 14, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28904375/a-rechargeable-iodine-carbon-battery-that-exploits-ion-intercalation-and-iodine-redox-chemistry
#5
Ke Lu, Ziyu Hu, Jizhen Ma, Houyi Ma, Liming Dai, Jintao Zhang
Graphitic carbons have been used as conductive supports for developing rechargeable batteries. However, the classic ion intercalation in graphitic carbon has yet to be coupled with extrinsic redox reactions to develop rechargeable batteries. Herein, we demonstrate the preparation of a free-standing, flexible nitrogen and phosphorus co-doped hierarchically porous graphitic carbon for iodine loading by pyrolysis of polyaniline coated cellulose wiper. We find that heteroatoms could provide additional defect sites for encapsulating iodine while the porous carbon skeleton facilitates redox reactions of iodine and ion intercalation...
September 13, 2017: Nature Communications
https://www.readbyqxmd.com/read/28900029/young-adulthood-and-adulthood-adiposity-in-relation-to-incidence-of-pancreatic-cancer-a-prospective-study-of-0-5-million-chinese-adults-and-a-meta-analysis
#6
Yuanjie Pang, Michael V Holmes, Christiana Kartsonaki, Yu Guo, Ling Yang, Zheng Bian, Yiping Chen, Fiona Bragg, Andri Iona, Iona Y Millwood, Junshi Chen, Liming Li, Zhengming Chen
BACKGROUND: Adult adiposity is positively associated with pancreatic cancer in Western populations. Little is known, however, about the association in China where many have lower body mass index (BMI) or about the relevance of young adulthood adiposity for pancreatic cancer in both Western and East Asian populations. METHODS: The China Kadoorie Biobank (CKB) recruited 512 891 adults aged 30-79 years during 2004-2008, recording 595 incident cases of pancreatic cancer during 8-year follow-up...
September 12, 2017: Journal of Epidemiology and Community Health
https://www.readbyqxmd.com/read/28894283/jinqijiangtang-tablets-for-pre-diabetes-a-randomized-double-blind-and-placebo-controlled-clinical-trial
#7
Hui Wang, Liping Guo, Hongcai Shang, Ming Ren, Xuemei Wang, Dehui Wang, Jianzong Chen, Shuanglei Li, Liming Chen, Yue Wang, Zhi Liu, Jingbo Zhai, Yuzhen Song, Hongbo Cao, Junhua Zhang, Chunxiang Liu, Xiao Sun, Da Huo, Wei Mu, Li Zhang, Wenke Zheng, Xiaoyan Yan, Chen Yao
This study observed the efficacy and safety of JinqiJiangtang tablets (JQJT tablets, a traditional Chinese patent medicine) for pre-diabetes. Four hundred patients with pre-diabetes at five centres were treated for 12months and followed for an additional 12months to investigate the preventative effects of JQJT tablets (Registration ID: ChiCTR-PRC-09000401). The incidence rate of diabetes mellitus was the primary endpoint. The risk of converting from pre-diabetes to diabetes was 0.58-fold less in the JQJT tablets group than in the placebo group [HR (95% CI): 0...
September 11, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28893452/assessing-the-use-of-composts-from-multiple-sources-based-on-the-characteristics-of-carbon-mineralization-in-soil
#8
Xu Zhang, Yue Zhao, Longji Zhu, Hongyang Cui, Liming Jia, Xinyu Xie, Jiming Li, Zimin Wei
In order to improve soil quality, reduce wastes and mitigate climate change, it is necessary to understand the balance between soil organic carbon (SOC) accumulation and depletion under different organic waste compost amended soils. The effects of proportion (5%, 15%, 30%), compost type (sewage sludge (SS), tomato stem waste (TSW), municipal solid waste (MSW), kitchen waste (KW), cabbage waste (CW), peat (P), chicken manure (CM), dairy cattle manure (DCM)) and the black soil (CK). Their initial biochemical composition (carbon, nitrogen, C:N ratio) on carbon (C) mineralization in soil amended compost have been investigated...
September 8, 2017: Waste Management
https://www.readbyqxmd.com/read/28878204/analysis-of-antineutrophil-cytoplasm-antibody-from-118-730-patients-in-tertiary-hospitals-in-jiangxi-province-china
#9
Liming Tan, Anjun Jiao, Juanjuan Chen, Xiaojing Feng, Liuyue Xu, Siqi He, Fuyan Tan, Yongqing Jiang, Heng Luo, Hua Li, Yang Wu, Yongjian Tian, Tingting Zeng, Jianlin Yu, Liping Cao, Jianfeng Zheng, Hui Xu, Ming Wei, Wen Gan, Weihua Peng, Yanming Liu, Jing Hou, Jiangxia Xu, LiHua Shuai, Wenzhi Huang, Junyun Huang, Yan Lin, Jianrong Liu
BACKGROUND The discovery of antineutrophil cytoplasm antibody (ANCA) makes the early diagnosis of primary vasculitis possible, and also has important guiding significance for the diagnosis and treatment of secondary vasculitis. This study aimed to investigate the clinical significance of ANCA. MATERIAL AND METHODS ANCA was detected by indirect immunofluorescence assay (IIF), and anti-myeloperoxidase (MPO) antibody, and anti-proteinase 3 (PR3) antibody were detected by ELISA. The results were analyzed retrospectively...
September 7, 2017: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/28877180/decreased-complexity-of-glucose-dynamics-preceding-the-onset-of-diabetes-in-mice-and-rats
#10
Xiaohua Douglas Zhang, David Pechter, Liming Yang, Xiaoli Ping, Zuliang Yao, Rumin Zhang, Xiaolan Shen, Nina Xiaoyan Li, Jonathan Connick, Andrea R Nawrocki, Manu Chakravarthy, Cai Li
Continuous glucose monitoring (CGM) is a platform to measure blood glucose (BG) levels continuously in real time with high enough resolution to document their underlying fluctuations. Multiscale entropy (MSE) analysis has been proposed as a measure of time-series complexity, and when applied to clinical CGM data, MSE analysis revealed that diabetic patients have lower MSE complexity in their BG time series than healthy subjects. To determine if the clinical observations on complexity of glucose dynamics can be back-translated to relevant preclinical species used routinely in diabetes drug discovery, we performed CGM in both mouse (ob/ob) and rat (Zucker Diabetic Fatty, ZDF) models of diabetes...
2017: PloS One
https://www.readbyqxmd.com/read/28876029/-bioassay-guided-isolation-of-functional-components-from-hot-water-extract-of-chlorella-pyrenoidosa
#11
Jing Jia, Diansheng Xu, Xiuyuan Zhuang, Daojing Zhang, Liming Tao, Yuanguang Li
The main functional ingredients of hot water extract of Chlorella pyrenoidosa (CPE) were investigated through a bioassay-guided fractionation based on free radical scavenging and macrophage proliferation effects. The main functional ingredients of CPE were polysaccharides (PS) that were isolated by high pressure extraction, Sevag method, ethanol precipitation and ultrafiltration separation. Crude polysaccharides were further separated and purified by ion exchange chromatography DEAE52 and size exclusion chromatography Sephadex G-100...
May 25, 2017: Sheng Wu Gong Cheng Xue Bao, Chinese Journal of Biotechnology
https://www.readbyqxmd.com/read/28875707/remote-manipulation-of-ligand-nano-oscillations-regulates-adhesion-and-polarization-of-macrophages-in-vivo
#12
Heemin Kang, Sungkyu Kim, Dexter Siu Hong Wong, Hee Joon Jung, Sien Lin, Kaijie Zou, Rui Li, Gang Li, Vinayak P Dravid, Liming Bian
Macrophages play crucial roles in various immune-related responses, such as host defense, wound healing, disease progression, and tissue regeneration. Macrophages perform distinct and dynamic functions in vivo, depending on their polarization states, such as the pro-inflammatory M1 phenotype and pro-healing M2 phenotype. Remote manipulation of the adhesion of host macrophages to the implants and their subsequent polarization in vivo can be an attractive strategy to control macrophage polarization-specific functions but has rarely been achieved...
September 8, 2017: Nano Letters
https://www.readbyqxmd.com/read/28868123/orthotopic-liver-transplantation-from-cardiac-death-donors-in-the-mouse-a-new-model-and-evaluation-of-cardiac-death-time
#13
Zhenzhen Liu, Ning Pan, Xiangwei Lv, Song Li, Liming Wang, Qinlong Liu
OBJECTIVES: The goal of this research was to develop a mouse orthotopic liver transplantation (LTx) model from donor-after-cardiac-death (DCD) grafts. MATERIALS AND METHODS: Mice were randomly assigned to the experimental group or the sham group. The mice in the experimental group were divided into three groups according to the warm ischemia time (WIT) of liver graft: normal LTx, WIT 30 minute (min) +LTx and WIT 45 min +LTx. The descending aorta was clamped using a miniature aortic clamp to simulate cardiac arrest in the DCD grafts...
June 2017: Iranian Journal of Basic Medical Sciences
https://www.readbyqxmd.com/read/28867579/socs2-exacerbates-myocardial-injury-induced-by-ischemia-reperfusion-in-diabetic-mice-and-h9c2-cells-through-inhibiting-the-jak-stat-igf-1-pathway
#14
Mengting Sheng, Zirui Huang, Liming Pan, Min Yu, Cai Yi, Lin Teng, Ling He, Chen Gu, Chunli Xu, Junming Li
AIMS: This study aimed to investigate potential candidates and molecular mechanisms of myocardial ischemia/reperfusion (I/R) injury (MIRI) in type 2 diabetes mellitus. MAIN METHODS: Type 2 diabetic and myocardial I/R mouse models were established with a high fat-diet (HFD) for 24weeks and subjecting to global ischemia/reperfusion for 1h/3h, respectively. Microarray analysis was applied to screen differentially expressed genes (DEGs) in the hearts of these mice. Moreover, H9c2 cells were treated with high glucose (HG) and/or hypoxia and reoxygenation (H/R)...
August 31, 2017: Life Sciences
https://www.readbyqxmd.com/read/28864200/vascular-expression-of-angiopoietin1-%C3%AE-5%C3%AE-1-integrin-and-tight-junction-proteins-is-tightly-regulated-during-vascular-remodeling-in-the-post-ischemic-brain
#15
Jialan Sun, Liming Yu, Shu Huang, Xiaoyin Lai, Richard Milner, Longxuan Li
The post-stroke angiogenic response is accompanied by changes of tight junctions (TJs) of the blood-brain barrier (BBB). However, the precise dynamic change of TJ proteins (TJPs) in the different stages of stroke-induced vascular remodeling and the molecules mediating these processes have yet to be fully defined. To investigate the temporal relationship between changes in TJPs, the pro-angiogenic factor α5β1 integrin and the anti-permeability factor Ang1 in cerebral vessels following cerebral ischemic stroke, male C57Bl/6 mice were subject to 90min of ischemia by temporary occlusion of the middle cerebral artery followed by reperfusion and their brains analyzed 0, 1, 2, 4, 7 and 14days post-ischemia...
August 31, 2017: Neuroscience
https://www.readbyqxmd.com/read/28856588/whole-blood-microrna-markers-are-associated-with-acute-respiratory-distress-syndrome
#16
Zhaozhong Zhu, Liming Liang, Ruyang Zhang, Yongyue Wei, Li Su, Paula Tejera, Yichen Guo, Zhaoxi Wang, Quan Lu, Andrea A Baccarelli, Xi Zhu, Ednan K Bajwa, B Taylor Thompson, Guo-Ping Shi, David C Christiani
BACKGROUND: MicroRNAs (miRNAs) can play important roles in inflammation and infection, which are common manifestations of acute respiratory distress syndrome (ARDS). We assessed if whole blood miRNAs were potential diagnostic biomarkers for human ARDS. METHODS: This nested case-control study (N = 530) examined a cohort of ARDS patients and critically ill at-risk controls. Whole blood miRNA profiles and logistic regression analyses identified miRNAs correlated with ARDS...
August 30, 2017: Intensive Care Medicine Experimental
https://www.readbyqxmd.com/read/28853497/-vital-pulp-therapy-of-damaged-dental-pulp
#17
Zhou Xuedong, Huang Dingming, Liu Jianguo, Huang Zhengwei, Wei Xin, Yang Deqin, Zhao Jin, Chen Liming, Zhu Lin, Li Yanhong, Li Jiyao
The development of an expert consensus on vital pulp therapy can provide practical guidance for the improvement of pulp damage care in China. Dental pulp disease is a major type of illness that adversely affects human oral health. Pulp capping and pulpotomy are currently the main methods for vital pulp therapy. Along with the development of minimal invasion cosmetic dentistry, using different treatment technologies and materials reasonably, preserving healthy tooth tissue, and extending tooth save time have become urgent problems that call for immediate solution in dental clinics...
August 1, 2017: Hua Xi Kou Qiang Yi Xue za Zhi, Huaxi Kouqiang Yixue Zazhi, West China Journal of Stomatology
https://www.readbyqxmd.com/read/28844046/paracrine-effects-of-mesenchymal-stem-cells-on-the-activation-of-keratocytes
#18
Zhixin Jiang, Guangjie Liu, Fanlan Meng, Weiyi Wang, Peng Hao, Yang Xiang, Yuchuan Wang, RuiFang Han, Fang Li, Liming Wang, Xuan Li
AIMS: The purpose of this study is to investigate the impact of mesenchymal stem cell (MSC)-derived soluble factors on the function of keratocytes, with a particular focus on the processes involved in wound healing, including keratocyte activation, migration and proliferation as well as extracellular matrix (ECM) synthesis. METHODS: Primary cultured rabbit keratocytes were treated with MSC-conditioned medium (MSC-CM). The paracrine factors released by bone marrow MSCs were examined by ELISA...
August 26, 2017: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/28843065/self-assembled-n-cadherin-mimetic-peptide-hydrogels-promote-the-chondrogenesis-of-mesenchymal-stem-cells-through-inhibition-of-canonical-wnt-%C3%AE-catenin-signaling
#19
Rui Li, Jianbin Xu, Dexter Siu Hong Wong, Jinming Li, Pengchao Zhao, Liming Bian
N-cadherin, a transmembrane protein and major component of adherens junction, mediates cell-cell interactions and intracellular signaling that are important to the regulation of cell behaviors and organ development. Previous studies have identified mimetic peptides that possess similar bioactivity as that of N-cadherin, which promotes chondrogenesis of human mesenchymal stem cells (hMSCs); however, the molecular mechanism remains unknown. In this study, we combined the N-cadherin mimetic peptide (HAVDI) with the self-assembling KLD-12 peptide: the resultant peptide is capable of self-assembling into hydrogels functionalized with N-cadherin peptide in phosphate-buffered saline (PBS) at 37 °C...
August 16, 2017: Biomaterials
https://www.readbyqxmd.com/read/28841292/remote-control-of-multimodal-nanoscale-ligand-oscillations-regulates-stem-cell-adhesion-and-differentiation
#20
Heemin Kang, Dexter Siu Hong Wong, Xiaohui Yan, Hee Joon Jung, Sungkyu Kim, Sien Lin, Kongchang Wei, Gang Li, Vinayak P Dravid, Liming Bian
Cellular adhesion is regulated by the dynamic ligation process of surface receptors, such as integrin, to adhesive motifs, such as Arg-Gly-Asp (RGD). Remote control of adhesive ligand presentation using external stimuli is an appealing strategy for the temporal regulation of cell-implant interactions in vivo and was recently demonstrated using photochemical reaction. However, the limited tissue penetration of light potentially hampers the widespread applications of this method in vivo. Here, we present a strategy for modulating the nanoscale oscillations of an integrin ligand simply and solely by adjusting the frequency of an oscillating magnetic field to regulate the adhesion and differentiation of stem cells...
August 30, 2017: ACS Nano
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