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Liming Li

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https://www.readbyqxmd.com/read/28339038/lncrna%C3%A2-mediated-sirt1-foxo3a-and-sirt1-p53-signaling-pathways-regulate-type-ii-alveolar-epithelial-cell-senescence-in-patients-with-chronic-obstructive-pulmonary-disease
#1
Chao Gu, Yaqing Li, Jialiang Liu, Xiwang Ying, Yuanshun Liu, Jianping Yan, Chun Chen, Hongbin Zhou, Liming Cao, Yingyu Ma
The loss of alveolar structure and airspace enlargement are major pathological changes in chronic obstructive pulmonary disease (COPD). Type II alveolar epithelial cells (AECII) are involved in maintaining lung tissue repair and alveolar homeostasis. Long non‑coding RNAs (lncRNAs) are involved in multi‑regulating gene transcription, affecting processes including embryonic development, cell differentiation and cellular senescence. The primary aim of the present study was to explore the mechanisms of AECII senescence regulated by lncRNA‑mediated sirtuin 1 (SIRT1) and forkhead box O 3a (FoxO3a) signaling pathways in patients with COPD...
March 23, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28337388/the-clinical-significance-of-anti-mitotic-spindle-apparatus-antibody-msa-and-anti-centromere-antibody-aca-detected-in-patients-with-small-cell-lung-cancer-sclc
#2
Liming Tan, Yuhong Zhang, Yongqing Jiang, Hua Li, Juanjuan Chen, Feng Ming, Waimei Wang, Jianlin Yu, Tingting Zeng, Yongjian Tian, Yang Wu
PURPOSE: The project is aimed to detect anti-mitotic spindle apparatus antibody (MSA) and anti-centromere antibody (ACA) and explore the clinical value for the diagnosis of small cell lung cancer (SCLC), providing clinical evidence for molecular studies of SCLC. METHODS: 93 SCLC patients, 208 patients with other cancers and 50 healthy controls were enrolled in this study. MSA antibodies were detected by enzyme linked immunosorbent assay (ELISA). MSA, ACA and anti nuclear antibodies (ANA) were examined by indirect immuno-fluorescence (IIF)...
2017: American Journal of Clinical and Experimental Immunology
https://www.readbyqxmd.com/read/28336113/effect-of-branched-chain-amino-acid-ratio-on-the-proliferation-differentiation-and-expression-levels-of-key-regulators-involved-in-protein-metabolism-of-myocytes
#3
Yehui Duan, Liming Zeng, Fengna Li, Wenlong Wang, Yinghui Li, Qiuping Guo, Yujiao Ji, Bi'e Tan, Yulong Yin
OBJECTIVES: Branched-chain amino acids (BCAAs), including leucine (Leu), isoleucine (Ile), and valine (Val), are key regulators of protein synthesis in muscle. The aim of this study was to investigate the effect of different BCAA ratios (Leu:Ile:Val) on the proliferation, differentiation, and expression levels of the regulators related to protein metabolism of C2 C12 myocytes. METHODS: Studies were conducted in C2C12 myocytes exposed to different BCAA ratios (Leu: Ile: Val = 0, 1:0...
April 2017: Nutrition
https://www.readbyqxmd.com/read/28335373/dietary-patterns-and-insomnia-symptoms-in-chinese-adults-the-china-kadoorie-biobank
#4
Canqing Yu, Zumin Shi, Jun Lv, Yu Guo, Zheng Bian, Huaidong Du, Yiping Chen, Ran Tao, Ying Huang, Junshi Chen, Zhengming Chen, Liming Li
Limited attention has been paid to the effect of dietary patterns on sleep problems. In the present study, we analyzed the cross-sectional data of 481,242 adults aged 30-79 years from the China Kadoorie Biobank. A laptop-based questionnaire was administered to collect information on food intakes and insomnia symptoms. Logistic regression was used to estimate the odds ratios of each insomnia symptom according to quartiles of each dietary pattern, with adjustment for potential confounders. Two major dietary patterns were derived by factor analysis...
March 4, 2017: Nutrients
https://www.readbyqxmd.com/read/28335293/cholesterol-modified-amino-pullulan-nanoparticles-as-a-drug-carrier-comparative-study-of-cholesterol-modified-carboxyethyl-pullulan-and-pullulan-nanoparticles
#5
Xiaojun Tao, Yongchao Xie, Qiufang Zhang, Ximin Qiu, Liming Yuan, Yi Wen, Min Li, Xiaoping Yang, Ting Tao, Minghui Xie, Yanwei Lv, Qinyi Wang, Xing Feng
To search for nano-drug preparations with high efficiency in tumor treatment, we evaluated the drug-loading capacity and cell-uptake toxicity of three kinds of nanoparticles (NPs). Pullulan was grafted with ethylenediamine and hydrophobic groups to form hydrophobic cholesterol-modified amino-pullulan (CHAP) conjugates. Fourier transform infrared spectroscopy and nuclear magnetic resonance were used to identify the CHAP structure and calculate the degree of substitution of the cholesterol group. We compared three types of NPs with close cholesterol hydrophobic properties: CHAP, cholesterol-modified pullulan (CHP), and cholesterol-modified carboxylethylpullulan (CHCP), with the degree of substitution of cholesterol of 2...
September 8, 2016: Nanomaterials
https://www.readbyqxmd.com/read/28334358/ranges-of-cervical-intervertebral-disc-deformation-during-an-in-vivo-dynamic-flexion-extension-of-the-neck
#6
Yan Yu, Haiqing Mao, Jing-Sheng Li, Tsung-Yuan Tsai, Liming Cheng, Kirkham B Wood, Guoan Li, Thomas D Cha
While abnormal loading is widely believed to cause cervical spine disc diseases, in-vivo cervical disc deformation during dynamic neck motion has not been well delineated. This study investigated the range of cervical disc deformation during an in-vivo functional flexion-extension of the neck. Ten asymptomatic human subjects were tested using a combined dual fluoroscopic imaging system and MRI based 3D modeling technique. Overall disc deformation was determined using the changes of the space geometry between upper and lower endplates of each intervertebral segment (C3/4, C4/5, C5/6 and C6/7)...
March 23, 2017: Journal of Biomechanical Engineering
https://www.readbyqxmd.com/read/28334319/erbb4-acts-as-a-suppressor-in-the-development-of-hepatocellular-carcinoma
#7
Yao Liu, Liming Song, Hengli Ni, Lina Sun, Weijuan Jiao, Lin Chen, Qun Zhou, Tong Shen, Hongxia Cui, Tianming Gao, Jianming Li
ERBB4, one member of the epidermal growth factor receptor (EGFR) family, plays a key role in physiological and pathological processes. Recently, we identified that ERBB4 played a protective role from chronic hepatitis B virus infection. However, the role of ERBB4 in hepatocellular carcinoma (HCC) is still unclear. Here, we explore the role of ERBB4 in the development of HCC using in vitro models, in vivo animal models and clinical samples of HCC. Liver-specific ERBB4 knockout alleles and full ERBB4 except heart knockout mice were used in this study...
March 14, 2017: Carcinogenesis
https://www.readbyqxmd.com/read/28292261/genome-wide-analysis-of-a-avirulent-and-reveal-the-strain-induces-pro-tective-immunity-against-challenge-with-virulent-streptococcus-suis-serotype-2
#8
Jing Wang, Youjun Feng, Changjun Wang, Feng Zheng, Bachar Hassan, Liming Zhi, Wenjuan Li, Yi Yao, Elaine He, Shibo Jiang, Jiaqi Tang
BACKGROUND: It was previously reported in China that two recent large-scale outbreaks of Streptococcus suis serotype 2 (S. suis 2) infections in human were caused by two highly virulent S. suis 2 strains, from which a novel genomic island (GEI), associated with disease onset and progression and designated 89 K, was identified. Here, an avirulent strain, 05HAS68, was isolated from a clinically healthy pig. RESULTS: By comparing the genomes of this avirulent strain with virulent strains, it was found that massive genomic rearrangements occurred, resulting in alterations in gene expression that caused enormous single gene gain and loss...
March 14, 2017: BMC Microbiology
https://www.readbyqxmd.com/read/28289216/b-vitamins-attenuate-the-epigenetic-effects-of-ambient-fine-particles-in-a-pilot-human-intervention-trial
#9
Jia Zhong, Oskar Karlsson, Guan Wang, Jun Li, Yichen Guo, Xinyi Lin, Michele Zemplenyi, Marco Sanchez-Guerra, Letizia Trevisi, Bruce Urch, Mary Speck, Liming Liang, Brent A Coull, Petros Koutrakis, Frances Silverman, Diane R Gold, Tangchun Wu, Andrea A Baccarelli
Acute exposure to fine particle (PM2.5) induces DNA methylation changes implicated in inflammation and oxidative stress. We conducted a crossover trial to determine whether B-vitamin supplementation averts such changes. Ten healthy adults blindly received a 2-h, controlled-exposure experiment to sham under placebo, PM2.5 (250 μg/m(3)) under placebo, and PM2.5 (250 μg/m(3)) under B-vitamin supplementation (2.5 mg/d folic acid, 50 mg/d vitamin B6, and 1 mg/d vitamin B12), respectively. We profiled epigenome-wide methylation before and after each experiment using the Infinium HumanMethylation450 BeadChip in peripheral CD4(+) T-helper cells...
March 13, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28287251/cisplatin-induced-apoptosis-of-ovarian-cancer-a2780s-cells-by-activation-of-erk-p53-puma-signals
#10
Hao Song, Mei Wei, Wenfen Liu, Shulin Shen, Jiaqun Li, Liming Wang
Cisplatin (CDDP) is one of the most effective anticancer agents widely used in the treatment of solid tumors, including ovarian cancer. It is generally considered as a cytotoxic drug which kills cancer cells by causing DNA damage, and subsequently inducing apoptosis in cancer cells. However, the underlying mechanisms leading to cell apoptosis remain obscure. In this study, the signaling pathways involved in CDDP -induced apoptosis were examined using CDDP-sensitive ovarian cancer A2780s cells. A2780s cells were treated with CDDP (1...
March 13, 2017: Histology and Histopathology
https://www.readbyqxmd.com/read/28284964/optimal-control-of-a-malaria-model-with-asymptomatic-class-and-superinfection
#11
Liming Cai, Xuezhi Li, Necibe Tuncer, Maia Martcheva, Abid Ali Lashari
In this paper, we introduce a malaria model with an asymptomatic class in human population and exposed classes in both human and vector populations. The model assumes that asymptomatic individuals can get re-infected and move to the symptomatic class. In the case of an incomplete treatment, symptomatic individuals move to the asymptomatic class. If successfully treated, the symptomatic individuals recover and move to the susceptible class. The basic reproduction number, R0, is computed using the next generation approach...
March 9, 2017: Mathematical Biosciences
https://www.readbyqxmd.com/read/28273565/synthesis-and-cytotoxicity-of-oleanolic-acid-trisaccharide-saponins
#12
Liming Wang, Zengshang Wang, Sheng Su, Ying Xing, Yali Li, Ming Li, Jiangyun Liu, Shilin Yang
An array of oleanolic acid-type saponins based on β-hederin has been synthesized in a linear or one-pot manner. The cell viability assays indicate that synthetic saponins show antiproliferation activities in three cancer cell lines with IC50 values of 2.4-15.1 μM and hederacolchiside A1 being the most potent. The results demonstrate that the type of terminal monosaccharides and linkage position have apparent effects on cytotoxicities and selectivities of these saponins against cancer cell lines tested. This study is helpful for future development of more potent anticancer leads...
February 28, 2017: Carbohydrate Research
https://www.readbyqxmd.com/read/28259064/noninvasive-and-fast-measurement-of-blood-glucose-in-vivo-by-near-infrared-nir-spectroscopy
#13
Xue Jintao, Ye Liming, Liu Yufei, Li Chunyan, Chen Han
This research was to develop a method for noninvasive and fast blood glucose assay in vivo. Near-infrared (NIR) spectroscopy, a more promising technique compared to other methods, was investigated in rats with diabetes and normal rats. Calibration models are generated by two different multivariate strategies: partial least squares (PLS) as linear regression method and artificial neural networks (ANN) as non-linear regression method. The PLS model was optimized individually by considering spectral range, spectral pretreatment methods and number of model factors, while the ANN model was studied individually by selecting spectral pretreatment methods, parameters of network topology, number of hidden neurons, and times of epoch...
February 20, 2017: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
https://www.readbyqxmd.com/read/28254173/adherence-to-healthy-lifestyle-and-cardiovascular-diseases-in-the-chinese%C3%A2-population
#14
Jun Lv, Canqing Yu, Yu Guo, Zheng Bian, Ling Yang, Yiping Chen, Xuefeng Tang, Weiyuan Zhang, Yijian Qian, Yuelong Huang, Xiaoping Wang, Junshi Chen, Zhengming Chen, Lu Qi, Liming Li
BACKGROUND: Adherence to a combination of healthy lifestyle factors has been related to a considerable reduction of cardiovascular risk in white populations; however, little is known whether such associations persist in nonwhite populations like the Asian population. OBJECTIVES: This study aimed to examine the associations of a combination of modifiable, healthy lifestyle factors with the risks of ischemic cardiovascular diseases and estimate the proportion of diseases that could potentially be prevented by adherence to these healthy lifestyle patterns...
March 7, 2017: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/28249508/preliminary-experimental-investigation-of-an-x-band-cerenkov-type-high-power-microwave-oscillator-without-guiding-magnetic-field
#15
Liming Guo, Ting Shu, Zhiqiang Li, Jinchuan Ju, Xiaoting Fang
Among high power microwave (HPM) generators without guiding magnetic field, Cerenkov-type oscillator is expected to achieve a relatively high efficiency, which has already been realized in X-band in our previous simulation work. This paper presents the preliminary experimental investigations into an X-band Cerenkov-type HPM oscillator without guiding magnetic field. Based on the previous simulation structure, some modifications regarding diode structure were made. Different cathode structures and materials were tested in the experiments...
February 2017: Review of Scientific Instruments
https://www.readbyqxmd.com/read/28249201/genome-wide-screening-for-highly-discriminative-snps-for-personal-identification-and-their-assessment-in-world-populations
#16
Liming Li, Yi Wang, Shuping Yang, Mingying Xia, Yajun Yang, Jiucun Wang, Daru Lu, Xingwei Pan, Teng Ma, Pei Jiang, Ge Yu, Ziqin Zhao, Yuan Ping, Huaigu Zhou, Xueying Zhao, Hui Sun, Bing Liu, Dongtao Jia, Chengtao Li, Rile Hu, Hongzhou Lu, Xiaoyang Liu, Wenqing Chen, Qin Mi, Fuzhong Xue, Yongdong Su, Li Jin, Shilin Li
The applications of DNA profiling aim to identify perpetrators, missing family members and disaster victims in forensic investigations. Single nucleotide polymorphisms (SNPs) based forensic applications are emerging rapidly with a potential to replace short tandem repeats (STRs) based panels which are now being used widely, and there is a need for a well-designed SNP panel to meet such challenge for this transition. Here we present a panel of 175 SNP markers (referred to as Fudan ID Panel or FID), selected from ∼3...
February 16, 2017: Forensic Science International. Genetics
https://www.readbyqxmd.com/read/28245107/mussel-inspired-adhesive-and-tough-hydrogel-based-on-nanoclay-confined-dopamine-polymerization
#17
Lu Han, Xiong Lu, Kezhi Liu, Kefeng Wang, Liming Fang, Lu-Tao Weng, Hongping Zhang, Youhong Tang, Fuzeng Ren, Cancan Zhao, Guoxing Sun, Rui Liang, Zongjin Li
Adhesive hydrogels are attractive biomaterials for various applications, such as electronic skin, wound dressing, and wearable devices. However, fabricating a hydrogel with both adequate adhesiveness and excellent mechanical properties remains a challenge. Inspired by the adhesion mechanism of mussels, we used a two-step process to develop an adhesive and tough polydopamine-clay-polyacrylamide (PDA-clay-PAM) hydrogel. Dopamine was intercalated into clay nanosheets and limitedly oxidized between the layers, resulting in PDA-intercalated clay nanosheets containing free catechol groups...
March 6, 2017: ACS Nano
https://www.readbyqxmd.com/read/28244162/exploring-the-effect-of-ginsenoside-rh1-in-a-sleep-deprivation-induced-mouse-memory-impairment-model
#18
Cong Lu, Zhe Shi, Liming Dong, Jingwei Lv, Pan Xu, Yinghui Li, Lina Qu, Xinmin Liu
Panax ginseng C.A. Meyer (Araliaceae) has been used in traditional Chinese medicine for enhancing cognition for thousands of years. Ginsenoside Rh1, a constituent of ginseng root, as with other constituents, has memory-improving effects in normal mice and scopolamine-induced amnesic mice. Sleep deprivation (SD) is associated with memory impairment through induction of oxidative stress. The present study investigated the effect of Rh1 against SD-induced cognitive impairment and attempted to define the possible mechanisms involved...
February 28, 2017: Phytotherapy Research: PTR
https://www.readbyqxmd.com/read/28244120/the-histone-methyltransferase-suv39h2-contributes-to-non-alcoholic-steatohepatitis-in-mice
#19
Zhiwen Fan, Luyang Li, Min Li, Xinjian Zhang, Chenzhi Hao, Liming Yu, Sheng Zeng, Huihui Xu, Mingming Fang, Aiguo Shen, Thomas Jenuwein, Yong Xu
Uncontrolled inflammatory response highlights the central theme of non-alcoholic steatohepatitis (NASH), a growing global pandemic. Hepatocytes and macrophages represent two major sources of hepatic inflammation during NASH pathogenesis contributing to excessive synthesis of pro-inflammatory mediators. The epigenetic mechanism that accounts for the activation of hepatocytes and macrophages in this process remains obscure. Here we report that compared to wild type (WT) littermates, mice with a deficiency in the histone H3K9 methyltransferase Suv39h2 (KO) exhibited a less severe form of NASH induced by feeding with high-fat high-carbohydrate diet (HFD)...
February 28, 2017: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/28235543/protective-effects-of-linalool-against-amyloid-beta-induced-cognitive-deficits-and-damages-in-mice
#20
Pan Xu, Kezhu Wang, Cong Lu, Liming Dong, Li Gao, Ming Yan, Silafu Aibai, Yanyan Yang, Xinmin Liu
AIM: Amyloid-beta (Aβ)-mediated neurotoxicity plays a pivotal role in the pathogenesis of Alzheimer's disease (AD), which induces oxidative stress and apoptosis. Linalool (LI) is a volatile monoterpene showing positive effect in AD treatment. This study was designed to research the protective effect of LI against neurotoxicity and cognitive deficits induced by Aβ1-40 in mice. MAIN METHODS: Aβ1-40 (4μg) solution was injected in the bilateral hippocampus to induce cognitive deficits of mice...
February 21, 2017: Life Sciences
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