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Liming Li

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https://www.readbyqxmd.com/read/28102849/berberine-sonodynamic-therapy-induces-autophagy-and-lipid-unloading-in-macrophage
#1
Jiayuan Y Kou, Ying Li, Zhaoyu Y Zhong, Yueqing Q Jiang, Xuesong S Li, Xiaobo B Han, Zhongni N Liu, Ye Tian, Liming M Yang
Impaired autophagy in macrophages accompanies the progression of atherosclerosis and contributes to lipid loading in plaques and ineffective lipid degradation. Therefore, evoking autophagy and its associated cholesterol efflux may provide a therapeutic treatment for atherosclerosis. In the present study, berberine-mediated sonodynamic therapy (BBR-SDT) was used to induce autophagy and cholesterol efflux in THP-1 macrophages and derived foam cells. Following BBR-SDT, autophagy was increased in the macrophages, autophagy resistance in the foam cells was prevented, and cholesterol efflux was induced...
January 19, 2017: Cell Death & Disease
https://www.readbyqxmd.com/read/28099521/nuclear-localization-and-cleavage-of-stat6-is-induced-by-kaposi-s-sarcoma-associated-herpesvirus-for-viral-latency
#2
Chong Wang, Caixia Zhu, Fang Wei, Shujun Gao, Liming Zhang, Yuhong Li, Yanling Feng, Yin Tong, Jianqing Xu, Bin Wang, Zhenghong Yuan, Erle S Robertson, Qiliang Cai
Emerging evidence implies that STAT6 plays an important role in both the adaptive and innate immune responses to virus infection. Kaposi's sarcoma-associated herpesvirus (KSHV) is an oncogenic γ-herpesvirus agent associated with several human malignancies, including Kaposi's sarcoma (KS) and primary effusion lymphomas (PELs). Previously, we demonstrated that KSHV blocks IL-4-induced STAT6 phosphorylation and retains a basal IL-13/STAT6 constitutive activation for cell survival and proliferation. However, the mechanism by which KSHV regulates STAT6 remains largely unknown...
January 2017: PLoS Pathogens
https://www.readbyqxmd.com/read/28087860/retraction-note-triptolide-contributes-to-decrease-in-tlr4-expression-by-upregulating-mir-224-3p-to-inhibit-the-inflammatory-reaction-in-diabetic-nephropathy
#3
Bei Sun, Shaolan Hu, Yongmei Li, Endong Zhu, Li Li, Fei Han, Chun-Jun Li, Liming Chen
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December 20, 2016: Oncotarget
https://www.readbyqxmd.com/read/28077936/redox-proteomic-identification-of-carbonylated-proteins-in-autism-plasma-insight-into-oxidative-stress-and-its-related-biomarkers-in-autism
#4
Chengyun Feng, Youjiao Chen, Jintao Pan, Aochu Yang, Li Niu, Jie Min, Xianling Meng, Liping Liao, Kaoyuan Zhang, Liming Shen
BACKGROUND: Autism is a severe childhood neurological disorder with poorly understood etiology and pathology. Currently, there is no authentic laboratory test to confirm the diagnosis of autism. Oxidative damage may play a central role in the pathogenesis of autism. Present study is an effort to search for possible biomarkers of autism and further clarify the molecular changes associated with oxidative stress that occurs in the plasma of autistic children. METHODS: We performed redox proteomics analysis to compare carbonylated proteins in the plasma of autistic subjects and healthy controls...
2017: Clinical Proteomics
https://www.readbyqxmd.com/read/28077466/tea-consumption-and-risk-of-ischaemic-heart-disease
#5
Xia Li, Canqing Yu, Yu Guo, Zheng Bian, Jiahui Si, Ling Yang, Yiping Chen, Xiaolan Ren, Ge Jiang, Junshi Chen, Zhengming Chen, Jun Lv, Liming Li
OBJECTIVE: To prospectively examine the association between tea consumption and the risk of ischaemic heart disease (IHD). METHODS: Prospective study using the China Kadoorie Biobank; participants from 10 areas across China were enrolled during 2004-2008 and followed up until 31 December 2013. After excluding participants with cancer, heart disease and stroke at baseline, the present study included 199 293 men and 288 082 women aged 30-79 years at baseline...
January 11, 2017: Heart: Official Journal of the British Cardiac Society
https://www.readbyqxmd.com/read/28077330/dehydropachymic-acid-decreases-bafilomycin-a1-induced-%C3%AE-amyloid-accumulation-in-pc12-cells
#6
Mengyao Yu, Xiaoyan Xu, Nan Jiang, Wei Wei, Fang Li, Liming He, Xia Luo
ETHNOPHARMACOLOGICAL RELEVANCE: Fuling, the sclerotium of Poria cocos, was frequently used in traditional Chinese medicine (TCM) formulae for Alzheimer's disease (AD) intervention over the past 10 centuries. And its extracts exhibited significant effects in both cellular and animal models of AD in previous studies. However, its mechanisms on prevention and treatment of AD have not been well elucidated yet. AIM OF THE STUDY: To investigate the effect and corresponding mechanisms of dehydropachymic acid, which is one of the major triterpenes in Poria cocos, on the clearance of β-Amyloid accumulation in bafilomycin A1 induced PC12 cells...
January 7, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28071700/temperature-dependent-schottky-barrier-in-high-performance-organic-solar-cells
#7
Hui Li, Dan He, Qing Zhou, Peng Mao, Jiamin Cao, Liming Ding, Jizheng Wang
Organic solar cells (OSCs) have attracted great attention in the past 30 years, and the power conversion efficiency (PCE) now reaches around 10%, largely owning to the rapid material developments. Meanwhile with the progress in the device performance, more and more interests are turning to understanding the fundamental physics inside the OSCs. In the conventional bulk-heterojunction architecture, only recently it is realized that the blend/cathode Schottky junction serves as the fundamental diode for the photovoltaic function...
January 10, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28069431/small-rna-seq-analysis-reveals-microrna-regulation-of-the-imd-pathway-during-escherichia-coli-infection-in-drosophila
#8
Shengjie Li, Li Shen, Lianjie Sun, Jiao Xu, Ping Jin, Liming Chen, Fei Ma
Drosophila have served as a model for research on innate immunity for decades. However, knowledge of the post-transcriptional regulation of immune gene expression by microRNAs (miRNAs) remains rudimentary. In the present study, using small RNA-seq and bioinformatics analysis, we identified 67 differentially expressed miRNAs in Drosophila infected with Escherichia coli compared to injured flies at three time-points. Furthermore, we found that 21 of these miRNAs were potentially involved in the regulation of Imd pathway-related genes...
January 7, 2017: Developmental and Comparative Immunology
https://www.readbyqxmd.com/read/28064359/season-of-birth-and-the-risk-of-type-2-diabetes-in-adulthood-a-prospective-cohort-study-of-0-5-million-chinese-adults
#9
Jiahui Si, Canqing Yu, Yu Guo, Zheng Bian, Xia Li, Ling Yang, Yiping Chen, Huarong Sun, Bo Yu, Junshi Chen, Zhengming Chen, Jun Lv, Liming Li
AIMS/HYPOTHESIS: Season of birth as a surrogate for potential environmental exposure during fetal development and early postnatal life has shown an inconsistent association with adult type 2 diabetes in white populations living in high-latitude regions. The present study aimed to examine the association between birth seasonality and risk of adult type 2 diabetes in Chinese individuals living across wide regions of low latitude and lower to middle latitude. METHODS: Participants from the China Kadoorie Biobank were enrolled during 2004-2008 and followed up until 31 December 2013...
January 7, 2017: Diabetologia
https://www.readbyqxmd.com/read/28063165/diabetes-plasma-glucose-and-incidence-of-pancreatic-cancer-a-prospective-study-of-0-5-million-chinese-adults-and-a-meta-analysis-of-22-cohort-studies
#10
Yuanjie Pang, Christiana Kartsonaki, Yu Guo, Fiona Bragg, Ling Yang, Zheng Bian, Yiping Chen, Andri Iona, Iona Y Millwood, Jun Lv, Canqing Yu, Junshi Chen, Liming Li, Michael V Holmes, Zhengming Chen
Diabetes is associated with an increased risk of pancreatic cancer (PC) in Western populations. Uncertainty remains, however, about the relevance of plasma glucose for PC among people without diabetes and about the associations of diabetes and high blood glucose with PC in China where the increase in diabetes prevalence has been very recent. The prospective China Kadoorie Biobank (CKB) study recruited 512,000 adults aged 30-79 years from 10 diverse areas of China during 2004-08, recording 595 PC cases during 8 years of follow-up...
January 7, 2017: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/28051869/chemical-vapor-deposition-of-large-size-monolayer-mose2-crystals-on-molten-glass
#11
Jianyi Chen, Xiaoxu Zhao, Sherman J R Tan, Hai Xu, Bo Wu, Bo Liu, Deyi Fu, Wei Fu, Dechao Geng, Yanpeng Liu, Wei Liu, Wei Tang, Linjun Li, Wu Zhou, Tze Chien Sum, Kian Ping Loh
We report the fast growth of high-quality millimeter-size monolayer MoSe2 crystals on molten glass using an ambient pressure CVD system. We found that the isotropic surface of molten glass suppresses nucleation events and greatly improves the growth of large crystalline domains. Triangular monolayer MoSe2 crystals with sizes reaching ∼2.5 mm, and with a room-temperature carrier mobility up to ∼95 cm(2)/(V·s), can be synthesized in 5 min. The method can also be used to synthesize millimeter-size monolayer MoS2 crystals...
January 10, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28035761/analysis-of-swi-formation-and-propagation-events
#12
Zhiqiang Du, Dustin Kenneth Goncharoff, Xudong Cheng, Liming Li
The budding yeast, Saccharomyces cerevisiae, harbors several prions that are transmitted as altered, heritable protein conformations. [SWI(+) ] is one such prion whose determinant is Swi1, a subunit of the evolutionarily conserved chromatin-remodeling complex SWI/SNF. Despite the importance of Swi1, the molecular events that lead to [SWI(+) ] prionogenesis remain poorly understood. In this study, we have constructed floccullin-promoter-based URA3 reporters for [SWI(+) ] identification. Using these reporters, we show that the spontaneous formation frequency of [SWI(+) ] is significantly higher than that of [PSI(+) ] (prion form of Sup35)...
December 30, 2016: Molecular Microbiology
https://www.readbyqxmd.com/read/28035372/surgery-management-for-sporadic-small-%C3%A2-2-cm-non-functioning-pancreatic-neuroendocrine-tumors-a-consensus-statement-by-the-chinese-study-group-for-neuroendocrine-tumors-csnet
#13
Guang Yang, Meng Ji, Jie Chen, Rufu Chen, Ye Chen, Deliang Fu, Baohua Hou, Heguang Huang, Liming Jiang, Kaizhou Jin, Nengwen Ke, Ying Li, Yong Li, Houjie Liang, An'an Liu, Jie Luo, Quanxing Ni, Chengwei Shao, Boyong Shen, Weiqi Sheng, Bin Song, Jian Sun, Chunlu Tan, Huangying Tan, Qiyun Tang, Yingmei Tang, Xiaodong Tian, Jian Wang, Jie Wang, Wei Wang, Wei Wang, Zheng Wu, Jin Xu, Qiang Yan, Ning Yang, Yinmo Yang, Xiaoyu Yin, Xianjun Yu, Chunhui Yuan, Shan Zeng, Guochao Zhang, Renchao Zhang, Zhiwei Zhou, Zhaohui Zhu, Chenghao Shao
The incidence of small (≤2 cm), non-functioning pancreatic neuroendocrine tumors (NF-pNETs) increased in the last decades. Before making appropriate strategy for patients with NF-pNETs ≤2 cm, pathological confirmation is vital. Incidentally diagnosed, sporadic small NF-pNETs may bring aggressive behavior and poor prognosis, such as extrapancreatic extension, lymph nodal metastasis, distant metastasis and recurrence, even causing disease-related death. Understanding and formulating an appropriate strategy for the patients with sporadic small, non-functioning pancreatic neuroendocrine tumors have been controversial for some time...
February 2017: International Journal of Oncology
https://www.readbyqxmd.com/read/28033462/the-pharmacological-heterogeneity-of-nepenthone-analogs-in-conferring-highly-selective-and-potent-%C3%AE%C2%BA-opioid-agonistic-activities
#14
Wei Li, Jian-Dong Long, Yuan-Yuan Qian, Yu Long, Xue-Jun Xu, Yu-Jun Wang, Qing Shen, Zuo-Neng Wang, Xi-Cheng Yang, Li Xiao, Hong-Peng Sun, Yu-Long Xu, Yi-Yi Chen, Qiong Xie, Yong-Hui Wang, Li-Ming Shao, Jing-Gen Liu, Zhui-Bai Qiu, Wei Fu
To develop novel analgesics with no side effects or less side effects than traditional opioids is highly demanded to treat opioid receptor mediated pain and addiction issues. Recently, κ-opioid receptor (KOR) has been established as an attractive target, although its selective agonists could bear heterogeneous pharmacological activities. In this study, we designed and synthesized two new series of nepenthone derivatives by inserting a spacer (carbonyl) between 6α,14α-endo-ethenylthebaine and the 7α-phenyl substitution of the skeleton and by substituting the 17-N-methyl group with a cyclopropylmethyl group...
January 19, 2017: ACS Chemical Neuroscience
https://www.readbyqxmd.com/read/28029649/mir-200c-is-a-cmyc-activated-mirna-that-promotes-nasopharyngeal-carcinoma-by-downregulating-pten
#15
Pan Chen, Xiaofang Guo, Liming Zhang, Wenling Zhang, Qingyu Zhou, Zhi Tian, Ying Zheng, Qianjin Liao, Heran Wang, Guiyuan Li, Jin Huang, Xiayu Li
The c-Myc transcription factor regulates a complex transcriptional program that leads to cellular transformation by targeting a large number of protein-encoding genes and non-coding RNAs. In this study, we show that a microRNA, miR-200c, is a novel c-Myc target that promotes cellular transformation and metastasis in nasopharyngeal carcinoma. MiR-200c achieves this oncogenic effect, at least in part, by targeting and inhibiting the tumor suppressor gene PTEN (phosphatase and tensin homolog), which is a key inhibitor of the AKT kinase signaling that promotes tumorigenesis in nasopharyngeal carcinoma...
December 23, 2016: Oncotarget
https://www.readbyqxmd.com/read/28011428/characterization-of-fly-ash-ceramic-pellet-for-phosphorus-removal
#16
Shiyang Li, Richard A Cooke, Li Wang, Fang Ma, Rabin Bhattarai
Phosphorus has been recognized as a leading pollutant for surface water quality deterioration. In the Midwestern USA, subsurface drainage not only provides a pathway for excess water to leave the field but it also drains out nutrients like nitrogen (N) and phosphorus (P). Fly ash has been identified as one of the viable materials for phosphorus removal from contaminated waters. In this study, a ceramic pellet was manufactured using fly ash for P absorption. Three types of pellet with varying lime and clay proportions by weight (type 1: 10% lime + 30% clay, type 2: 20% lime + 20% clay, and type 3: 30% lime + 10% clay) were characterized and evaluated for absorption efficiency...
December 20, 2016: Journal of Environmental Management
https://www.readbyqxmd.com/read/28009471/interference-of-steroidogenesis-by-gold-nanorod-core-silver-shell-nanostructures-implications-for-reproductive-toxicity-of-silver-nanomaterials
#17
Xiumei Jiang, Liming Wang, Yinglu Ji, Jinglong Tang, Xin Tian, Mingjing Cao, Jingxuan Li, Shuying Bi, Xiaochun Wu, Chunying Chen, Jun-Jie Yin
As a widely used nanomaterial in daily life, silver nanomaterials may cause great concern to female reproductive system as they are found to penetrate the blood-placental barrier and gain access to the ovary. However, it is largely unknown about how silver nanomaterials influence ovarian physiology and functions such as hormone production. This study performs in vitro toxicology study of silver nanomaterials, focusing especially on cytotoxicity and steroidogenesis and explores their underlying mechanisms. This study exposes primary rat granulosa cells to gold nanorod core/silver shell nanostructures (Au@Ag NRs), and compares outcomes with cells exposed to gold nanorods...
December 23, 2016: Small
https://www.readbyqxmd.com/read/28005078/hypericin-mediated-sonodynamic-therapy-induces-autophagy-and-decreases-lipids-in-thp-1-macrophage-by-promoting-ros-dependent-nuclear-translocation-of-tfeb
#18
Xuesong Li, Xin Zhang, Longbin Zheng, Jiayuan Kou, Zhaoyu Zhong, Yueqing Jiang, Wei Wang, Zengxiang Dong, Zhongni Liu, Xiaobo Han, Jing Li, Ye Tian, Yajun Zhao, Liming Yang
Lipid catabolism disorder is the primary cause of atherosclerosis. Transcription factor EB (TFEB) prevents atherosclerosis by activating macrophage autophagy to promote lipid degradation. Hypericin-mediated sonodynamic therapy (HY-SDT) has been proved non-invasively inducing THP-1-derived macrophage apoptosis; however, it is unknown whether macrophage autophagy could be triggered by HY-SDT to influence cellular lipid catabolism via regulating TFEB. Here, we report that HY-SDT resulted in the time-dependent THP-1-derived macrophage autophagy activation through AMPK/AKT/mTOR pathway...
December 22, 2016: Cell Death & Disease
https://www.readbyqxmd.com/read/28003250/association-of-major-depression-with-risk-of-ischemic-heart-disease-in-a-mega-cohort-of-chinese-adults-the-china-kadoorie-biobank-study
#19
Na Liu, Xiong-Fei Pan, Canqing Yu, Jun Lv, Yu Guo, Zheng Bian, Ling Yang, Yiping Chen, Tangchun Wu, Zhengming Chen, An Pan, Liming Li
BACKGROUND: Increasing evidence has suggested that major depression (MD) is associated with an increased risk of ischemic heart disease (IHD). We examined this association in Chinese adults using data from the China Kadoorie Biobank study. METHODS AND RESULTS: Over 0.5 million adults aged 30 to 79 years were followed from baseline interview (2004-2008) until December 31, 2013. Past year MD was measured with the modified Chinese version of Composite International Diagnostic Interview-Short Form at baseline...
December 21, 2016: Journal of the American Heart Association
https://www.readbyqxmd.com/read/27997885/streptozotocin-inhibits-electrophysiological-determinants-of-excitatory-and-inhibitory-synaptic-transmission-in-ca1-pyramidal-neurons-of-rat-hippocampal-slices-reduction-of-these-effects-by-edaravone
#20
Ting Ju, Yuru Li, Xiaoran Wang, Lifeng Xiao, Li Jiang, Shanshan Zhou, Meimei Yang, Tingting Zhao, Lina Sun, Tingjiao Liu, Jinghan Lin, Yi Xu, Liming Zhang
BACKGROUND: Streptozotocin (STZ) has served as an agent to generate an Alzheimer's disease (AD) model in rats, while edaravone (EDA), a novel free radical scavenger, has recently emerged as an effective treatment for use in vivo and vitro AD models. However, to date, these beneficial effects of EDA have only been clearly demonstrated within STZ-induced animal models of AD and in cell models of AD. A better understanding of the mechanisms of EDA may provide the opportunity for their clinical application in the treatment of AD...
2016: Cellular Physiology and Biochemistry
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