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Liming Li

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https://www.readbyqxmd.com/read/28646129/microscope-enhanced-the-efficacy-and-safety-of-anterior-cervical-surgery-for-managing-cervical-ossification-of-the-posterior-longitudinal-ligament
#1
Mingxiao Sun, Lili Kong, Zhaofu Jiang, Liming Li, Bing Lu
BACKGROUND We aimed to compare microscope-assisted anterior cervical surgery with traditional open-base surgery for treating cervical ossification of the posterior longitudinal ligament (OPLL). MATERIAL AND METHODS Patients were grouped into microscope-assisted anterior cervical surgery group (case group, n=30) and conventional anterior cervical surgery group (control group, n=30). Baseline characteristics, intraoperative and post-operative indexes including operation time, blood loss amount, duration of hospitalization, visual analogue scale (VAS), and complication rate were recorded...
June 24, 2017: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/28637778/breastfeeding-and-the-risk-of-maternal-cardiovascular-disease-a-prospective-study-of-300%C3%A2-000-chinese-women
#2
Sanne A E Peters, Ling Yang, Yu Guo, Yiping Chen, Zheng Bian, Jianwei Du, Jie Yang, Shanpeng Li, Liming Li, Mark Woodward, Zhengming Chen
BACKGROUND: Breastfeeding confers substantial benefits to child health and has also been associated with lower risk of maternal cardiovascular diseases (CVDs) in later life. However, the evidence on the effects of CVD is still inconsistent, especially in East Asians, in whom the frequency and duration of breastfeeding significantly differ from those in the West. METHODS AND RESULTS: In 2004-2008, the nationwide China Kadoorie Biobank recruited 0.5 million individuals aged 30 to 79 years from 10 diverse regions across China...
June 21, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/28605451/age-at-menarche-and-incidence-of-diabetes-a-prospective-study-of-300-000-women-in-china
#3
Ling Yang, Liming Li, Sanne A E Peters, Robert Clarke, Yu Guo, Yiping Chen, Zheng Bian, Paul Sherliker, Jiyuan Yin, Zhenzhu Tang, Chunmei Wang, Xiaohuan Wang, Libo Zhang, Mark Woodward, Zhengming Chen
Previous studies of mostly Western populations have reported inconsistent associations between age at menarche and risk of diabetes. We examined such associations among Chinese women who tend to have later menarche age than women in West. China Kadoorie Biobank recruited 302,632 women aged 30-79 years from 10 areas across China in 2004-8, recording 5,391 incident cases of diabetes during 7-years follow-up among 270,345 women without diabetes, cardiovascular disease or cancer at baseline. Cox regression models yielded adjusted hazard ratios (HRs) for incident diabetes associated with age at menarche...
June 9, 2017: American Journal of Epidemiology
https://www.readbyqxmd.com/read/28602000/integrated-waste-load-allocation-for-river-water-pollution-control-under-uncertainty-a-case-study-of-tuojiang-river-china
#4
Jiuping Xu, Shuhua Hou, Liming Yao, Chaozhi Li
This paper presents a bi-level optimization waste load allocation programming model under a fuzzy random environment to assist integrated river pollution control. Taking account of the leader-follower decision-making in the water function zones framework, the proposed approach examines the decision making feedback relationships and conflict coordination between the river basin authority and the regional Environmental Protection Agency (EPA) based on the Stackelberg-Nash equilibrium strategy. In the pollution control system, the river basin authority, as the leader, allocates equitable emissions rights to different subareas, and the then subarea EPA, as the followers, reallocates the limited resources to various functional zones to minimize pollution costs...
June 10, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28600221/synthesis-and-biological-evaluation-of-novel-steroidal-5%C3%AE-8%C3%AE-endoperoxide-derivatives-with-aliphatic-side-chain-as-potential-anticancer-agents
#5
Ming Bu, Tingting Cao, Hongxia Li, Mingzhou Guo, Burton B Yang, Yue Zhou, Na Zhang, Chengchu Zeng, Liming Hu
By inspiration of significant anti-cancer activity of our previously screened natural ergosterol peroxide (EP), a series of novel steroidal 5α,8α-endoperoxide derivatives 5a-d and 14a-f were designed, synthesized, and biologically evaluated for their in vitro anti-proliferative inhibitory and cytotoxic activity. The results revealed that most of these compounds showed moderate-to-excellent anti-proliferative effects against the tested cancer cell lines (i.e. HepG2, SK-Hep1, MDA-MB-231 and MCF-7). Among them, compound 5b and 14d exhibited preferable inhibitory activities (IC50 of 5b and 14d are 8...
June 9, 2017: Steroids
https://www.readbyqxmd.com/read/28594401/upconversion-nanoparticle-mediated-photodynamic-therapy-induces-autophagy-and-cholesterol-efflux-of-macrophage-derived-foam-cells-via-ros-generation
#6
Xiaobo B Han, Hongxia X Li, Yueqing Q Jiang, Hao Wang, Xuesong S Li, Jiayuan Y Kou, Yinghong H Zheng, Zhongni N Liu, Hong Li, Jing Li, Dou Dou, You Wang, Ye Tian, Liming M Yang
Macrophage-derived foam cells are a major component of atherosclerotic plaques and have an important role in the progression of atherosclerotic plaques, thus posing a great threat to human health. Photodynamic therapy (PDT) has emerged as a therapeutic strategy for atherosclerosis. Here, we investigated the effect of PDT mediated by upconversion fluorescent nanoparticles encapsulating chlorin e6 (UCNPs-Ce6) on the cholesterol efflux of THP-1 macrophage-derived foam cells and explored the possible mechanism of this effect...
June 8, 2017: Cell Death & Disease
https://www.readbyqxmd.com/read/28593646/cancer-incidence-and-mortality-a-cohort-study-in-china-2008-2013
#7
Rui Pan, Meng Zhu, Canqing Yu, Jun Lv, Yu Guo, Zheng Bian, Ling Yang, Yiping Chen, Zhibin Hu, Zhengming Chen, Liming Li, Hongbing Shen
The National Central Cancer Registry of China (NCCR) was the only available source of cancer monitoring in China, even though only about 70% of cancer registration sites were qualified by now. In this study, based on a national large prospective cohort-the China Kadoorie Biobank (CKB), we aimed to provide additional cancer statistics and compare the difference of cancer burden between urban and rural areas of China. A total of 497,693 cancer-free participants aged 35-74 years were recruited and successfully followed up from 2004 to 2013 in 5 urban and 5 rural areas across China...
June 8, 2017: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/28592782/family-history-and-stroke-risk-in-china-evidence-from-a-large-cohort-study
#8
Tian Tian, Guangfu Jin, Canqing Yu, Jun Lv, Yu Guo, Zheng Bian, Ling Yang, Yiping Chen, Hongbing Shen, Zhengming Chen, Zhibin Hu, Liming Li
BACKGROUND AND PURPOSE: Large cohort studies on relationship between family history of stroke (FHS) and stroke risk are lacking in Asians. We aimed to systematically evaluate the association of FHS with stroke risk in a cohort study of 0.5 million Chinese adults. METHODS: Information about FHS was self-reported. The median follow-up time was 7.16 years and the end-point of follow-up was incident stroke, which was entered directly into the China Kadoorie Biobank system...
May 2017: Journal of Stroke
https://www.readbyqxmd.com/read/28587562/a-method-to-induce-human-cortical-long-term-potentiation-by-acoustic-stimulation
#9
Guanxiong Lei, Zeqi Zhao, Yalan Li, Liming Yu, Xin Zhang, Yan Yan, Xiaoyan Ma, Qian Wang, Keshuang Wang, Duo Zhang, Weidong Shen, Yuehua Qiao, Shiming Yang
OBJECT: Acoustic stimulation induced LTP in the human auditory cortex was successfully recorded for the first time by electroencephalography (EEG) using a stimulus of 1 kHz pure-tone in 2005. However, it was barely reproduced, given considerable challenges to reliably elicit and accurately record the enhanced potentials in vivo. The purpose of this paper was to explore whether acoustic stimuli other than 1 kHz pure-tone could generate LTP or not. MEASURES: To answer this question, we proposed a tetanic-stimulation paradigm of pure-tones, narrow-band noises (NBNs) and white noise (WN) to elicit LTP in human subjects...
June 7, 2017: Acta Oto-laryngologica
https://www.readbyqxmd.com/read/28584524/fibroblast-growth-factor-21-deficiency-attenuates-experimental-colitis-induced-adipose-tissue-lipolysis
#10
Liming Liu, Cuiqing Zhao, Ying Yang, Xiaoxia Kong, Tuo Shao, Li Ren, Xinyu Zhuang, Baishuang Yin, Gerald Dryden, Craig McClain, Weimin Luan, Wenke Feng
AIMS: Nutrient deficiencies are common in patients with inflammatory bowel disease (IBD). Adipose tissue plays a critical role in regulating energy balance. Fibroblast growth factor 21 (FGF21) is an important endocrine metabolic regulator with emerging beneficial roles in lipid homeostasis. We investigated the impact of FGF21 in experimental colitis-induced epididymal white adipose tissue (eWAT) lipolysis. METHODS: Mice were given 2.5% dextran sulfate sodium (DSS) ad libitum for 7 days to induce colitis...
2017: Gastroenterology Research and Practice
https://www.readbyqxmd.com/read/28582543/adherence-to-a-healthy-lifestyle-and-the-risk-of-type-2-diabetes-in-chinese-adults
#11
Jun Lv, Canqing Yu, Yu Guo, Zheng Bian, Ling Yang, Yiping Chen, Ximin Hu, Wei Hou, Junshi Chen, Zhengming Chen, Lu Qi, Liming Li
Background: Simultaneously adhering to multiple healthy lifestyle factors has been related to up to 90% reduction in type 2 diabetes (T2DM) incidence in White populations; however, little is known about whether such protective effects persist in other non-White populations. Methods: We examined the associations of six lifestyle factors with T2DM in the China Kadoorie Biobank of 461 211 participants aged 30-79 years without diabetes, cardiovascular diseases or cancer at baseline...
June 3, 2017: International Journal of Epidemiology
https://www.readbyqxmd.com/read/28577335/application-of-whole-lesion-histogram-analysis-of-pharmacokinetic-parameters-in-dynamic-contrast-enhanced-mri-of-breast-lesions-with-the-caipirinha-dixon-twist-vibe-technique
#12
Zhiwei Li, Tao Ai, Yiqi Hu, Xu Yan, Marcel Dominik Nickel, Xiao Xu, Liming Xia
PURPOSE: To investigate the application of whole-lesion histogram analysis of pharmacokinetic parameters for differentiating malignant from benign breast lesions on dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI). MATERIALS AND METHODS: In all, 92 women with 97 breast lesions (26 benign and 71 malignant lesions) were enrolled in this study. Patients underwent dynamic breast MRI at 3T using a prototypical CAIPIRINHA-Dixon-TWIST-VIBE (CDT-VIBE) sequence and a subsequent surgery or biopsy...
June 3, 2017: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/28575818/in-situ-studies-on-the-micro-structure-evolution-of-a2w2o7-a-li-na-k-during-melting-by-high-temperature-raman-spectroscopy-and-density-functional-theory
#13
Jian Wang, Jinglin You, Min Wang, Liming Lu, Songming Wan, A A Sobol
In-situ high temperature Raman spectroscopic (HTRS) technique in combination with density functional theory (DFT) analysis has been adopted to investigate the micro-structure of solid and molten A2W2O7 (A=Li, Na, K). The [WO6] octahedra were found to be connected to each other by corner and edge sharing in the crystalline Li2W2O7 and K2W2O7 compounds. In the crystal lattice of Na2W2O7, on the other hand, the [WO4] tetrahedra and [WO6] octahedra were found to coexist and paired by corner sharing. Although the structural diversity has clearly led to distinct Raman spectra of the crystalline A2W2O7 compounds, the spectra of their melts tended to be analogous, showing the typical vibration modes of (W2O7)(2-) dimer...
May 23, 2017: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
https://www.readbyqxmd.com/read/28571745/acetylation-of-mkl1-by-pcaf-regulates-pro-inflammatory-transcription
#14
Liming Yu, Zilong Li, Mingming Fang, Yong Xu
Inflammation is considered a fundamental host defense mechanism and, when aberrantly activated, contributes to a host of human diseases. Previously we have reported that the transcriptional regulator megakaryocytic leukemia 1 (MKL1) plays a role programming cellular inflammatory response by modulating NF-κB activity. Here we report that MKL1 was acetylated in vivo and pro-inflammatory stimuli (TNF-α and LPS) augmented MKL1 acetylation accompanying increased MKL1 binding to NF-κB target promoters. Further analysis revealed that the lysine acetyltransferase PCAF mediated MKL1 acetylation: TNF-α and LPS promoted the interaction between MKL1 and PCAF whereas depletion of PCAF abrogated the induction of MKL1 acetylation by TNF-α and LPS...
May 30, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28566273/an-expanded-genome-wide-association-study-of-type-2-diabetes-in-europeans
#15
Robert A Scott, Laura J Scott, Reedik Mägi, Letizia Marullo, Kyle J Gaulton, Marika Kaakinen, Natalia Pervjakova, Tune H Pers, Andrew D Johnson, John D Eicher, Anne U Jackson, Teresa Ferreira, Yeji Lee, Clement Ma, Valgerdur Steinthorsdottir, Gudmar Thorleifsson, Lu Qi, Natalie R Van Zuydam, Anubha Mahajan, Han Chen, Peter Almgren, Ben F Voight, Harald Grallert, Martina Müller-Nurasyid, Janina S Ried, William N Rayner, Neil Robertson, Lennart C Karssen, Elisabeth M van Leeuwen, Sara M Willems, Christian Fuchsberger, Phoenix Kwan, Tanya M Teslovich, Pritam Chanda, Man Li, Yingchang Lu, Christian Dina, Dorothee Thuillier, Loic Yengo, Longda Jiang, Thomas Sparso, Hans A Kestler, Himanshu Chheda, Lewin Eisele, Stefan Gustafsson, Mattias Frånberg, Rona J Strawbridge, Rafn Benediktsson, Astradur B Hreidarsson, Augustine Kong, Gunnar Sigurðsson, Nicola D Kerrison, Jian'an Luan, Liming Liang, Thomas Meitinger, Michael Roden, Barbara Thorand, Tõnu Esko, Evelin Mihailov, Caroline Fox, Ching-Ti Liu, Denis Rybin, Bo Isomaa, Valeriya Lyssenko, Tiinamaija Tuomi, David J Couper, James S Pankow, Niels Grarup, Christian T Have, Marit E Jørgensen, Torben Jørgensen, Allan Linneberg, Marilyn C Cornelis, Rob M van Dam, David J Hunter, Peter Kraft, Qi Sun, Sarah Edkins, Katharine R Owen, John Rb Perry, Andrew R Wood, Eleftheria Zeggini, Juan Tajes-Fernandes, Goncalo R Abecasis, Lori L Bonnycastle, Peter S Chines, Heather M Stringham, Heikki A Koistinen, Leena Kinnunen, Bengt Sennblad, Thomas W Mühleisen, Markus M Nöthen, Sonali Pechlivanis, Damiano Baldassarre, Karl Gertow, Steve E Humphries, Elena Tremoli, Norman Klopp, Julia Meyer, Gerald Steinbach, Roman Wennauer, Johan G Eriksson, Satu Mӓnnistö, Leena Peltonen, Emmi Tikkanen, Guillaume Charpentier, Elodie Eury, Stéphane Lobbens, Bruna Gigante, Karin Leander, Olga McLeod, Erwin P Bottinger, Omri Gottesman, Douglas Ruderfer, Matthias Blüher, Peter Kovacs, Anke Tonjes, Nisa M Maruthur, Chiara Scapoli, Raimund Erbel, Karl-Heinz Jöckel, Susanne Moebus, Ulf de Faire, Anders Hamsten, Michael Stumvoll, Panagiotis Deloukas, Peter J Donnelly, Timothy M Frayling, Andrew T Hattersley, Samuli Ripatti, Veikko Salomaa, Nancy L Pedersen, Bernhard O Boehm, Richard N Bergman, Francis S Collins, Karen L Mohlke, Jaakko Tuomilehto, Torben Hansen, Oluf Pedersen, Inês Barroso, Lars Lannfelt, Erik Ingelsson, Lars Lind, Cecilia M Lindgren, Stephane Cauchi, Philippe Froguel, Ruth Jf Loos, Beverley Balkau, Heiner Boeing, Paul W Franks, Aurelio Barricarte Gurrea, Domenico Palli, Yvonne T van der Schouw, David Altshuler, Leif C Groop, Claudia Langenberg, Nicholas J Wareham, Eric Sijbrands, Cornelia M van Duijn, Jose C Florez, James B Meigs, Eric Boerwinkle, Christian Gieger, Konstantin Strauch, Andres Metspalu, Andrew D Morris, Colin Na Palmer, Frank B Hu, Unnur Thorsteinsdottir, Kari Stefansson, Josée Dupuis, Andrew P Morris, Michael Boehnke, Mark I McCarthy, Inga Prokopenko
To characterise type 2 diabetes (T2D) associated variation across the allele frequency spectrum, we conducted a meta-analysis of genome-wide association data from 26,676 T2D cases and 132,532 controls of European ancestry after imputation using the 1000 Genomes multi-ethnic reference panel. Promising association signals were followed-up in additional data sets (of 14,545 or 7,397 T2D cases and 38,994 or 71,604 controls). We identified 13 novel T2D-associated loci (p<5×10(-8)), including variants near the GLP2R, GIP, and HLA-DQA1 genes...
May 31, 2017: Diabetes
https://www.readbyqxmd.com/read/28559787/a-3d-computational-model-of-transcutaneous-electrical-nerve-stimulation-for-estimating-a%C3%AE-tactile-nerve-fiber-excitability
#16
Kaihua Zhu, Liming Li, Xuyong Wei, Xiaohong Sui
Tactile sensory feedback plays an important role in our daily life. Transcutaneous electrical nerve stimulation (TENS) is widely accepted to produce artificial tactile sensation. To explore the underlying mechanism of tactile sensation under TENS, this paper presented a novel 3D TENS computational model including an active Aβ tactile nerve fiber (TNF) model and a forearm finite element model with the fine-layered skin structure. The conduction velocity vs. fiber diameter and strength-duration relationships in this combined TENS model matched well with experimental data...
2017: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/28552643/formation-of-graphene-oxide-hybridized-nanogels-for-combinative-anticancer-therapy
#17
Xin Xu, Jine Wang, Yifeng Wang, Liming Zhao, Yulin Li, Changsheng Liu
The low efficacy and high toxicity of chemotherapy have been driving increasing attention on development of combined anticancer therapy technique. In the current work, graphene oxide (GO)-hybridized nanogels (AGD) were developed for delivery of an anticancer drug (doxorubicin (DOX)), which simultaneously presented photothermal therapeutic effects against cancer cells. AGD nanogels were fabricated by in situ incorporating GO nanoplatelets into a biodegradable polymer (alginate) via a double emulsion approach using a disulfide molecule as crosslinker, followed by DOX encapsulation via electrostatic interactions...
May 26, 2017: Nanomedicine: Nanotechnology, Biology, and Medicine
https://www.readbyqxmd.com/read/28545103/combined-effects-of-cotyledon-excision-and-nursery-fertilization-on-root-growth-nutrient-status-and-outplanting-performance-of-quercus-variabilis-container-seedlings
#18
Wenhui Shi, Mark Bloomberg, Guolei Li, Shuchai Su, Liming Jia
Artificial excision of the distal part of acorns in order to promote germination is well researched in oak seedling cultivation studies. However, studies of combined effects of cotyledon excision and nursery fertilization on container seedlings are lacking, especially for seedling root growth and outplanting performance. This study aimed to explore the main effects of cotyledon excision on Quercus variabilis seedling emergence characteristics and demonstrated the combined effects of cotyledon excision and nursery fertilization on seedling quality to improve Quercus variabilis seedling outplanting performance...
2017: PloS One
https://www.readbyqxmd.com/read/28541289/mir-29b-contributes-to-multiple-types-of-muscle-atrophy
#19
Jin Li, Mun Chun Chan, Yan Yu, Yihua Bei, Ping Chen, Qiulian Zhou, Liming Cheng, Lei Chen, Olivia Ziegler, Glenn C Rowe, Saumya Das, Junjie Xiao
A number of microRNAs (miRNAs, miRs) have been shown to play a role in skeletal muscle atrophy, but their role is not completely understood. Here we show that miR-29b promotes skeletal muscle atrophy in response to different atrophic stimuli in cells and in mouse models. miR-29b promotes atrophy of myotubes differentiated from C2C12 or primary myoblasts, and conversely, its inhibition attenuates atrophy induced by dexamethasone (Dex), TNF-α and H2O2 treatment. Targeting of IGF-1 and PI3K(p85α) by miR-29b is required for induction of muscle atrophy...
May 25, 2017: Nature Communications
https://www.readbyqxmd.com/read/28539730/near-infrared-spectroscopy-as-a-process-analytical-technology-tool-for-monitoring-the-parching-process-of-traditional-chinese-medicine-based-on-two-kinds-of-chemical-indicators
#20
Kaiyue Li, Weiying Wang, Yanping Liu, Su Jiang, Guo Huang, Liming Ye
BACKGROUND: The active ingredients and thus pharmacological efficacy of traditional Chinese medicine (TCM) at different degrees of parching process vary greatly. OBJECTIVE: Near-infrared spectroscopy (NIR) was used to develop a new method for rapid online analysis of TCM parching process, using two kinds of chemical indicators (5-(hydroxymethyl) furfural [5-HMF] content and 420 nm absorbance) as reference values which were obviously observed and changed in most TCM parching process...
April 2017: Pharmacognosy Magazine
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