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Intrinsic sphincter deficiency

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https://www.readbyqxmd.com/read/28503734/retropubic-tissue-fixation-system-tensioned-mini-sling-carried-out-under-local-anesthesia-cures-stress-urinary-incontinence-and-intrinsic-sphincter-deficiency-1-year-data
#1
Ryoko Nakamura, Masahiro Yao, Yoshiko Maeda, Akiko Fujisaki, Yuki Sekiguchi
OBJECTIVES: To assess the outcomes of the tissue fixation system midurethral sling for the treatment of intrinsic sphincter deficiency. METHODS: We retrospectively studied a total of 96 intrinsic sphincter deficiency patients treated with the tissue fixation system midurethral sling at Yokohama Motomachi Women's Clinic from 2006 to 2015. We evaluated intraoperative and 1-year postoperative results. Regarding the cure rate, we divided patients into three groups: (i) patients with maximum urethral closure pressure <20 and Valsalva leak point pressure <65 combined (n = 17); (ii) patients with maximum urethral closure pressure <20 (n = 55); and (iii) patients with Valsalva leak point pressure <65 (n = 47)...
May 14, 2017: International Journal of Urology: Official Journal of the Japanese Urological Association
https://www.readbyqxmd.com/read/28380161/associated-factors-to-urinary-incontinence-in-women-undergoing-urodynamic-testing
#2
Juliana Cristina Pereira da Silva, Zaida Aurora Sperli Geraldes Soler, Anneliese DominguesWysocki
OBJECTIVE: Analyzing factors associated with urinary incontinence (UI) among women submitted to urodynamic testing. METHOD: A cross-sectional study of 150 women attended at a urological center. Data were analyzed using univariate and multivariate statistics. RESULTS: White women (79.3%), overweight (45.3%), menopausal (53.3%), who drink coffee (82.7%), sedentary (65.3%), who had vaginal birth (51.4%), with episiotomy (80%), and who underwent the Kristeller maneuver (69%)...
April 3, 2017: Revista da Escola de Enfermagem da U S P
https://www.readbyqxmd.com/read/28361511/therapeutic-efficacy-of-a-new-procedure-for-male-urinary-incontinence-combining-a-suburethral-polypropylene-mesh-and-cardiovascular-patch
#3
Shu-Yu Wu, Yuan-Hong Jiang, Hann-Chorng Kuo
PURPOSE: Stress urinary incontinence (SUI) in men is a complication secondary to prostatectomy or resulting from neurological lesions. This study presents our experiences with male suburethral slings over the past decade. METHODS: In this study, we considered patients who presented with SUI and were diagnosed with an intrinsic sphincteric deficiency due to postprostatectomy incontinence (PPI) or other causes (non-PPI). Patients who underwent the suburethral sling procedure using a polypropylene mesh and a cardiovascular patch were retrospectively included...
March 24, 2017: International Neurourology Journal
https://www.readbyqxmd.com/read/28215049/laparoscopic-implantation-of-artificial-urinary-sphincter-in-women-with-intrinsic-sphincter-deficiency-mid-term-outcomes
#4
Carlos Ferreira, Pierre-Emannuel Brychaert, Johann Menard, Eric Mandron
OBJECTIVES: To analyze the safety and the mid-term continence rates of laparoscopic implantation of artificial urinary sphincter in women. METHODS: A total of 52 women with intrinsic sphincter deficiency underwent a laparoscopic artificial urinary sphincter implantation from 2005 to 2015 at Surgical Clinic Du Pré, Le Mans, France. The artificial urinary sphincter was implanted around the bladder neck by a transperitoneal laparoscopic approach to the Retzius space...
April 2017: International Journal of Urology: Official Journal of the Japanese Urological Association
https://www.readbyqxmd.com/read/28210823/non-ablative-erbium-yag-laser-for-the-treatment-of-type-iii-stress-urinary-incontinence-intrinsic-sphincter-deficiency
#5
Adrian Gaspar, Hugo Brandi
The objective of this pilot study was to determine the safety and efficacy of a new non-ablative erbium YAG laser procedure for the treatment of type III stress urinary incontinence (intrinsic sphincter deficiency) in women. Twenty-two patients with a Valsalva leak point pressure less than 60 cm H2O were recruited and treated with a non-ablative erbium laser delivering low fluence pulses inside the whole length of the urethra through a specially designed cannula. Treatment consisted of two treatment sessions with a 3-week interval in-between...
April 2017: Lasers in Medical Science
https://www.readbyqxmd.com/read/28152525/para-urethral-injections-with-urolastic%C3%A2-for-treatment-of-female-stress-urinary-incontinence-subjective-improvement-and-safety
#6
Allert M de Vries, Hendrikje M K van Breda, Jimmy G Fernandes, Pieter L Venema, John P F A Heesakkers
INTRODUCTION: Female stress urinary incontinence (SUI) is often treated surgically. Urethral bulking agents are a minimally invasive alternative, especially in patients suffering from intrinsic sphincter deficiency, but often with limited long-term efficacy. Urolastic® is a non-deformable, non-resorbable silicone elastomer that is used as an injectable. Its properties might result in a more durable response after injection. If this durability factor can be combined with a low complication rate, this can become a useful treatment option...
February 3, 2017: Urologia Internationalis
https://www.readbyqxmd.com/read/28139863/role-of-intrinsic-sphincter-deficiency-with-and-without-urethral-hypomobility-on-the-outcome-of-tape-insertion
#7
Edyta Wlaźlak, Volker Viereck, Jacek Kociszewski, Andrzej Kuszka, Oliver Rautenberg, Claudia Walser, Grzegorz Surkont, Marianne Gamper, Mathias K Fehr
AIMS: Intrinsic sphincter deficiency (ISD) is a known risk factor for therapy failure after tension-free vaginal tape (TVT) insertion. The purpose of this study was to investigate if the severity of ISD alone or other factors such as urethral mobility and tape localization influence outcomes. METHODS: One hundred and nine women with urodynamically determined ISD, a TVT insertion, and a 6-month follow-up visit were included. Urethral length, mobility, and tape localization were evaluated by pelvic floor sonography...
January 31, 2017: Neurourology and Urodynamics
https://www.readbyqxmd.com/read/28118171/decreased-urethral-volume-is-comparable-to-funneling-as-a-predictor-of-intrinsic-sphincter-deficiency
#8
Andrea Chua Santiago, Lieschen H Quiroz, S Abbas Shobeiri
OBJECTIVES: The aims of this study were to determine the association between x-ray funneling and ultrasound urethral sphincter complex measurements and to compare the reliability of funneling versus urethral volume measurement in the detection of intrinsic sphincter deficiency (ISD). METHODS: This was a retrospective analysis, which included 54 stress incontinent women dichotomized into those with (1) ISD and (2) no ISD. The presence of bladder neck funneling was diagnosed by fluoroscopic images obtained at the time of video-urodynamics testing...
January 24, 2017: Female Pelvic Medicine & Reconstructive Surgery
https://www.readbyqxmd.com/read/28057078/determinates-of-muscle-precursor-cell-therapy-efficacy-in-a-nonhuman-primate-model-of-intrinsic-urinary-sphincter-deficiency
#9
James Koudy Williams, Ashley Dean, Shannon Lankford, Tracy Criswell, Gopal Badlani, Karl-Erik Andersson
BACKGROUND: Cell therapy for intrinsic urinary sphincter deficiency (ISD) in women has been moderately effective, and improvements are needed. To improve treatment efficacy, it is important to better understand determinates of cell efficacy in the different patient cohorts. We have reported that in nonhuman primates the chronicity of ISD may affect cell efficacy, but additional factors (age, psychosocial stress, hormone status, body weight) can be associated with many disease/treatment outcomes in women - and these factors are the focus of this study...
January 6, 2017: Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/27918341/two-cases-of-suspected-rejection-of-polydimethylsiloxane-urethral-bulking-agent
#10
Alaina Town Bennett, Emily Spencer Lukacz
We report the cases of 2 women who had urethral bulking injections with polydimethylsiloxane for stress urinary incontinence with intrinsic sphincter deficiency and reported initial improvement of symptoms followed by rapid return of stress urinary incontinence several weeks later associated with extrusion of the bulking material. We hypothesize this unique adverse outcome could represent immune rejection of this urethral bulking agent.
May 2017: Female Pelvic Medicine & Reconstructive Surgery
https://www.readbyqxmd.com/read/27872025/contemporary-review-of-artificial-urinary-sphincters-for-male-stress-urinary-incontinence
#11
REVIEW
Faysal A Yafi, Mary K Powers, Jonathan Zurawin, Wayne J G Hellstrom
INTRODUCTION: The most common cause of urinary incontinence in men after radical prostatectomy is intrinsic sphincter deficiency, which can affect long-term quality of life. The prevalence of stress urinary incontinence (SUI) after radical prostatectomy has been reported to be 2.5% to 90%. For patients with moderate to severe male SUI, the artificial urinary sphincter (AUS) is considered the gold standard in surgical treatment. AIM: To review the available literature on the development, patient selection, surgical technique, complications, and management of AUS for male SUI...
April 2016: Sexual Medicine Reviews
https://www.readbyqxmd.com/read/27808489/the-role-of-detrusor-overactivity-in-urinary-incontinence-after-radical-prostatectomy-a-systematic-review
#12
Antonio L Pastore, Giovanni Palleschi, Ester Illiano, Alessandro Zucchi, Antonio Carbone, Elisabetta Costantini
INTRODUCTION: The purpose of this review was to assess the evidence provided by Literature regarding the role of detrusor overactivity (DO) in determining urinary incontinence in patients submitted to radical prostatectomy. EVIDENCE ACQUISITION: The research was based on the online PubMed database spanning the period from November 1997 to May 2016.The review was conducted in accordance with the systematic review guidelines provided by the Cochrane Collaboration and the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA)...
November 3, 2016: Minerva Urologica e Nefrologica, the Italian Journal of Urology and Nephrology
https://www.readbyqxmd.com/read/27721639/role-of-urodynamics-in-stress-urinary-incontinence-a-critical-appraisal
#13
Shirish Dattatraya Yande, Omkar Vinay Joglekar, Maya Joshi
INTRODUCTION: Role of urodynamics prior to surgery of stress urinary incontinence (SUI) is under constant debate. Demonstration of the presence of detrusor overactivity is the only aspect that has been emphasized in the literature so far. We believe that there are number of other factors which may influence the evaluation and in turn the choice of surgical management and prediction of outcome of treatment. They are as follows: (1) Presence of voiding inefficiency, (2) asymptomatic detrusor overactivity, (3) and severity of SUI...
July 2016: Journal of Mid-life Health
https://www.readbyqxmd.com/read/27717380/local-versus-intravenous-injections-of-skeletal-muscle-precursor-cells-in-nonhuman-primates-with-acute-or-chronic-intrinsic-urinary-sphincter-deficiency
#14
J Koudy Williams, Gopal Badlani, Ashley Dean, Shannon Lankford, Kimberly Poppante, Tracy Criswell, Karl-Erik Andersson
BACKGROUND: Many factors may influence the efficacy of cell therapy for intrinsic urinary sphincter deficiency (ISD), including the route of administration of the cells and the condition of the sphincter. The goal of this study was to compare local versus intravenous administration of autologous skeletal muscle precursor cells (skMPCs) when administered to nonhuman primates (NHPs) with either acute or chronic ISD. METHODS: Thirty-two adult female monkeys were divided into eight groups (n = 4/group): (1) control; (2) surgically induced ISD/no treatment; (3) acute ISD (6-week duration)/local vehicle only; (4) acute ISD/local skMPC injection; (5) acute ISD/systemic skMPC; (6) chronic ISD (6-month duration)/local vehicle; (7) chronic ISD/local skMPC; (8) chronic ISD/systemic skMPC...
October 7, 2016: Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/27706005/stress-urinary-incontinence-in-women-with-multiple-sclerosis
#15
Caroline Massot, Hichem Khenioui, Olivier Agnani, Marc-Alexandre Guyot, Patrick Hautecoeur, Cécile Donze
PURPOSE: To report the prevalence and risk factors of stress urinary incontinence (SUI) and the prevalence of intrinsic sphincter deficiency in women with multiple sclerosis (MS). METHODS: We conducted a retrospective study. Female patients with MS, followed for lower urinary tract symptoms (LUTS) during a 15-year period were included. Demographic data, MS history, expanded disability status scale (EDSS) score at the urodynamic visit, obstetrical past, birth weight, LUTS, and urodynamic findings were collected...
September 2016: International Neurourology Journal
https://www.readbyqxmd.com/read/27607858/burch-retropubic-urethropexy-compared-with-midurethral-sling-with-concurrent-sacrocolpopexy-a-randomized-controlled-trial
#16
RANDOMIZED CONTROLLED TRIAL
Emanuel C Trabuco, Christopher J Klingele, Roberta E Blandon, John A Occhino, Amy L Weaver, Michaela E McGree, Maureen A Lemens, John B Gebhart
OBJECTIVE: To compare efficacy and safety of retropubic Burch urethropexy and a midurethral sling in women with stress urinary incontinence (SUI) undergoing concomitant pelvic floor repair with sacrocolpopexy. METHODS: Women were randomly assigned to Burch retropubic urethropexy (n=56) or retropubic midurethral sling (n=57) through dynamic allocation balancing age, body mass index, history of prior incontinence surgery, intrinsic sphincter deficiency, preoperative incontinence diagnosis, and prolapse stage...
October 2016: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/27393694/levator-ani-defects-in-patients-with-stress-urinary-incontinence-three-dimensional-endovaginal-ultrasound-assessment
#17
Aparna Hegde, Vivian C Aguilar, G Willy Davila
INTRODUCTION AND HYPOTHESIS: To determine the prevalence of levator ani (LA) muscle subdivision defects in patients with SUI using three-dimensional endovaginal ultrasound (3D EVUS). METHODS: This is a prospective cohort study of 100 patients with pure or predominant urodynamic SUI who underwent 3D EVUS. The 3D cubes obtained were analyzed and the LA muscle was divided into three subgroups: the puboperinealis/puboanalis, the puborectalis, and the iliococcygeus/pubococcygeus...
January 2017: International Urogynecology Journal
https://www.readbyqxmd.com/read/27351325/reproducibility-of-leak-point-pressure-in-female-stress-urinary-incontinence
#18
Eu Chang Hwang, Sun Ouck Kim, Dong Deuk Kwon
PURPOSE: To assess the reproducibility of the Valsalva leak point pressure (VLPP) based on urodynamics in females with stress urinary incontinence (SUI). MATERIALS AND METHODS: From October 2008 to December 2009, 65 consecutive women with urodynamically confirmed SUI underwent duplicate VLPP measurements. The intra-individual reproducibility of the VLPP recording obtained by one urologist was determined. The two observations were separated by a 10-min interval. RESULTS: The differences between the repeated measurements were not significant (initial vs...
June 28, 2016: Urology Journal
https://www.readbyqxmd.com/read/27267321/cell-versus-chemokine-therapy-in-a-nonhuman-primate-model-of-chronic-intrinsic-urinary-sphincter-deficiency
#19
J Koudy Williams, Ashley Dean, Sherif Badra, Shannon Lankford, Kimberly Poppante, Gopal Badlani, Karl-Erik Andersson
PURPOSE: Mixed efficacy results of autologous skeletal muscle precursor cell therapy in women with chronic intrinsic urinary sphincter deficiency have increased interest in the therapeutic value of alternative regenerative medicine approaches. The goal of this study was to compare the effects of the cell homing chemokine CXCL12 (C-X-C motif chemokine 12) and skeletal muscle precursor cells on chronic urinary sphincter regeneration in chronic intrinsic urinary sphincter deficiency. MATERIALS AND METHODS: Five million autologous skeletal muscle precursor cells or 100 ng CXCL12 were injected in the urinary sphincter complex of adult female cynomolgus monkeys with chronic (6-month history) intrinsic urinary sphincter deficiency...
June 4, 2016: Journal of Urology
https://www.readbyqxmd.com/read/27265221/histological-and-urodynamic-effects-of-autologous-stromal-vascular-fraction-extracted-from-fat-tissue-with-minimal-ex%C3%A2-vivo-manipulation-in-a-porcine-model-of-intrinsic-sphincter-deficiency
#20
Romain Boissier, Jeremy Magalon, Florence Sabatier, Julie Veran, Laurent Giraudo, Sophie Giusiano, Stephane Garcia, Françoise Dignat-George, Laurent Arnaud, Guy Magalon, Eric Lechevallier, Stephane Berdah, Gilles Karsenty
PURPOSE: To evaluate the healing abilities of autologous stem cell therapy (stromal vascular fraction) prepared from adipose tissue we used an automated system without an ex vivo culture phase in a pig model of intrinsic sphincteric deficiency. MATERIALS AND METHODS: A total of 15 pigs underwent endoscopic section of the urethral sphincter. Animals were then randomly assigned to 3 groups, including 1) controls without stromal vascular fraction injection, 2) early injection with stromal vascular fraction 2 to 3 days after section and 3) late stromal vascular fraction injection delivery 30 days after injury...
September 2016: Journal of Urology
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