Yifang Yuan, Aoming Jin, Bruce Neal, Xiangxian Feng, Qianku Qiao, Hongxia Wang, Ruijuan Zhang, Jiayu Li, Peifen Duan, La'e Cao, Hui Zhang, Senke Hu, Huijuan Li, Pei Gao, Gaoqiang Xie, Jianhui Yuan, Lili Cheng, Sujuan Wang, Haijun Zhang, Wenyi Niu, Hai Fang, Minghui Zhao, Runlin Gao, Junshi Chen, Paul Elliott, Darwin Labarthe, Yangfeng Wu
There is a paucity of high-quality evidence on the effectiveness and safety of salt reduction strategies, particularly for older people, who have the most to benefit but are at higher risk of adverse effects. Here, we conducted a clinical trial in which 48 residential elderly care facilities in China (1,612 participants including 1,230 men and 382 women, 55 years or older) were cluster-randomized using a 2 × 2 factorial design to provision of salt substitute (62.5% NaCl and 25% KCl) versus usual salt and to a progressively restricted versus usual supply of salt or salt substitute for 2 years...
April 2023: Nature Medicine