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Yangfeng Wu

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https://www.readbyqxmd.com/read/28810873/six-month-adherence-to-statin-use-and-subsequent-risk-of-major-adverse-cardiovascular-events-mace-in-patients-discharged-with-acute-coronary-syndromes
#1
Gaoqiang Xie, Yihong Sun, Phyo Kyaw Myint, Anushka Patel, Xingzi Yang, Min Li, Xian Li, Tao Wu, Shenshen Li, Runlin Gao, Yangfeng Wu
BACKGROUND: The evidence of adherence to statin decreasing risk of major adverse cardiovascular events (MACEs) is still lack among patients discharged with acute coronary syndrome (ACS). Our objective is to determine the relationship between six-month adherence to statins and subsequent risk of MACEs in patients discharged with ACS. METHODS: Using two prospective registry cohorts (CPACS-1 and -2), we analyzed data from 12,516 consecutive patients with ACS who were prescribed statin at hospital discharge and survived beyond 6 months without recurrent myocardial infarction (MI) or stroke...
August 15, 2017: Lipids in Health and Disease
https://www.readbyqxmd.com/read/28763548/effect-of-oral-methylprednisolone-on-clinical-outcomes-in-patients-with-iga-nephropathy-the-testing-randomized-clinical-trial
#2
RANDOMIZED CONTROLLED TRIAL
Jicheng Lv, Hong Zhang, Muh Geot Wong, Meg J Jardine, Michelle Hladunewich, Vivek Jha, Helen Monaghan, Minghui Zhao, Sean Barbour, Heather Reich, Daniel Cattran, Richard Glassock, Adeera Levin, David Wheeler, Mark Woodward, Laurent Billot, Tak Mao Chan, Zhi-Hong Liu, David W Johnson, Alan Cass, John Feehally, Jürgen Floege, Giuseppe Remuzzi, Yangfeng Wu, Rajiv Agarwal, Hai-Yan Wang, Vlado Perkovic
Importance: Guidelines recommend corticosteroids in patients with IgA nephropathy and persistent proteinuria, but the effects remain uncertain. Objective: To evaluate the efficacy and safety of corticosteroids in patients with IgA nephropathy at risk of progression. Design, Setting, and Participants: The Therapeutic Evaluation of Steroids in IgA Nephropathy Global (TESTING) study was a multicenter, double-blind, randomized clinical trial designed to recruit 750 participants with IgA nephropathy (proteinuria greater than 1 g/d and estimated glomerular filtration rate [eGFR] of 20 to 120 mL/min/1...
August 1, 2017: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/28577665/rationale-design-and-baseline-characteristics-of-the-salt-substitute-and-stroke-study-ssass-a-large-scale-cluster-randomized-controlled-trial
#3
RANDOMIZED CONTROLLED TRIAL
Bruce Neal, Maoyi Tian, Nicole Li, Paul Elliott, Lijing L Yan, Darwin R Labarthe, Liping Huang, Xuejun Yin, Zhixin Hao, Sandrine Stepien, Jingpu Shi, Xiangxian Feng, Jianxin Zhang, Yuhong Zhang, Ruijuan Zhang, Yangfeng Wu
Lowering sodium intake with a reduced-sodium, added potassium salt substitute has been proved to lower blood pressure levels. Whether the same strategy will also reduce the risks of vascular outcomes is uncertain and controversial. The SSaSS has been designed to test whether sodium reduction achieved with a salt substitute can reduce the risk of vascular disease. The study is a large-scale, open, cluster-randomized controlled trial done in 600 villages across 5 provinces in China. Participants have either a history of stroke or an elevated risk of stroke based on age and blood pressure level at entry...
June 2017: American Heart Journal
https://www.readbyqxmd.com/read/28509725/telmisartan-and-hydrochlorothiazide-antihypertensive-treatment-in-high-sodium-intake-population-a-randomized-double-blind-trial
#4
Puhong Zhang, Hongyi Wang, Lei Sun, Jing Zhang, Yang Xi, Yangfeng Wu, Lijing L Yan, Xian Li, Ningling Sun
OBJECTIVES: To compare the blood pressure (BP)-lowering effects of telmisartan 40 mg/day and hydrochlorothiazide (HCTZ) 25 mg/day in high sodium intake patients with mild-to-moderate hypertension in China. METHODS: In this randomized, double-blind trial, eligible patients were randomly divided into telmisartan and HCTZ groups with three follow-ups scheduled on days 15, 30, and 60 after enrollment to compare BP decrease, hypokalemia, and other adverse events after intervention...
May 13, 2017: Journal of Hypertension
https://www.readbyqxmd.com/read/28389125/use-of-cardiovascular-prevention-treatments-after-acute-coronary-syndrome-in-china-and-associated-factors
#5
Emily R Atkins, Xin Du, Yangfeng Wu, Runlin Gao, Anushka Patel, Clara K Chow
BACKGROUND: Prevention of repeat cardiovascular events is an important means of addressing the increasing burden of coronary heart disease in China, however there is minimal information about the use of cardiovascular prevention treatment following acute coronary syndrome (ACS) in China. METHODS: We analysed data from baseline and 6, 12, 18, and 24-month follow-up surveys of 15,140 consecutive ACS patients recruited in 70 hospitals from 17 provinces of China. We describe the use of indicated cardiovascular prevention medicines, risk factor control, change over time and factors associated with continued prevention...
March 27, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28388683/factors-attributed-to-the-higher-in-hospital-mortality-of-st-elevation-myocardial-infarction-patients-admitted-during-off-hour-in-comparison-with-those-during-regular-hour
#6
Min Li, Shenshen Li, Xin Du, Tao Wu, Xian Li, Changsheng Ma, Yong Huo, Dayi Hu, Runlin Gao, Yangfeng Wu
BACKGROUND: In-hospital mortality of patients with ST elevation myocardial infarction (STEMI) admitted during off-hour was reported higher than those admitted during regular hour, but which factors cause the difference remains largely unknown though the difference in medical resources was often accused. METHODS AND RESULTS: This registry-based study recruited 7456 STEMI patients prospectively from 99 level two hospitals across China. Generalized linear mixed models were applied to quantify the risk of in-hospital death attributed to admission time and the explainers of its change, accounting for the clustering of patients within hospitals...
2017: PloS One
https://www.readbyqxmd.com/read/28363686/treatment-and-outcomes-of-acute-coronary-syndromes-in-women-an-analysis-of-a-multicenter-quality-improvement-chinese-study
#7
Xin Du, Anushka Patel, Xian Li, Yangfeng Wu, Fiona Turnbull, Runlin Gao
BACKGROUND: Variations in care and outcomes by sex in patients with acute coronary syndrome (ACS) have been reported worldwide. The aims of this study are to describe ACS management according to sex in China and the effects of a quality improvement program in Chinese male and female ACS patients. METHODS AND RESULTS: Clinical Pathways for Acute Coronary Syndromes - Phase 2 (CPACS-2) was a cluster randomized trial to test whether a clinical pathways-based intervention would improve ACS management in China...
March 24, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28230322/comparative-effectiveness-and-safety-of-different-basal-insulins-in-a-real-world-setting
#8
Linong Ji, Puhong Zhang, Dongshan Zhu, Juming Lu, Xiaohui Guo, Yangfeng Wu, Xian Li, Jiachao Ji, Weiping Jia, Wenying Yang, Dajin Zou, Zhiguang Zhou, Yan Gao, Satish K Garg, Changyu Pan, Jianping Weng, Sanjoy K Paul
AIMS: To compare glucose control and safety of different basal insulin therapies (BI, including Insulin NPH, glargine and detemir) in real-world clinical settings based on a large-scale registry study. METHODS: In this multi-center 6-month prospective observational study, patients with type 2 diabetes (HbA1c ≥ 7%) who were uncontrolled by oral anti-diabetic drugs (OADs) and were willing to initiate BI therapy were enrolled from 209 hospitals within 8 regions of China...
February 23, 2017: Diabetes, Obesity & Metabolism
https://www.readbyqxmd.com/read/28105735/observational-registry-of-basal-insulin-treatment-orbit-in-patients-with-type-2-diabetes-uncontrolled-with-oral-antihyperglycaemic-drugs-real-life-use-of-basal-insulin-in-china
#9
Linong Ji, Puhong Zhang, Dongshan Zhu, Xian Li, Jiachao Ji, Juming Lu, Xiaohui Guo, Weiping Jia, Jianping Weng, Yangfeng Wu, Wenying Yang, Dajin Zou, Zhiguang Zhou, Changyu Pan, Yan Gao, Satish K Garg
AIMS: To examine treatment patterns following basal insulin (BI) introduction in type 2 diabetes mellitus (T2DM) patients under real-world conditions across China. MATERIALS AND METHODS: Overall, 18 995 patients inadequately controlled (HbA1c ≥ 53 mmol/mol [7%]) with oral antihyperglycaemic drugs (OADs) and willing to receive BI treatment were registered at 209 hospitals and followed at baseline (visit 1), 3 months (visit 2) and 6 months (visit 3)...
June 2017: Diabetes, Obesity & Metabolism
https://www.readbyqxmd.com/read/27935977/the-effects-of-a-community-based-sodium-reduction-program-in-rural-china-a-cluster-randomized-trial
#10
RANDOMIZED CONTROLLED TRIAL
Nicole Li, Lijing L Yan, Wenyi Niu, Chen Yao, Xiangxian Feng, Jianxin Zhang, Jingpu Shi, Yuhong Zhang, Ruijuan Zhang, Zhixin Hao, Hongling Chu, Jing Zhang, Xian Li, Jianhong Pan, Zhifang Li, Jixin Sun, Bo Zhou, Yi Zhao, Yan Yu, Michael Engelgau, Darwin Labarthe, Jixiang Ma, Stephen MacMahon, Paul Elliott, Yangfeng Wu, Bruce Neal
BACKGROUND: Average sodium intake and stroke mortality in northern China are both among the highest in the world. An effective, low-cost strategy to reduce sodium intake in this population is urgently needed. OBJECTIVE: We sought to determine the effects of a community-based sodium reduction program on salt consumption in rural northern China. DESIGN: This study was a cluster-randomized trial done over 18 months in 120 townships (one village from each township) from five provinces...
2016: PloS One
https://www.readbyqxmd.com/read/27772744/obesity-is-associated-with-better-survival-and-functional-outcome-after-acute-intracerebral-hemorrhage
#11
MULTICENTER STUDY
Weiping Sun, Ying Xian, Yining Huang, Wei Sun, Ran Liu, Fan Li, Jade W Wei, Ji-Guang Wang, Ming Liu, Yangfeng Wu, Lawrence K S Wong, Craig S Anderson
OBJECTIVE: To evaluate the association of obesity measured by body mass index (BMI) with mortality and functional outcome in patients with acute intracerebral hemorrhage (ICH). METHODS: Data were from 1571 patients with ICH enrolled in a national, multi-centre, prospective, hospital-based register: the ChinaQUEST (Quality Evaluation of Stroke Care and Treatment) study. The outcomes included all-cause mortality at 12months, and death or high dependency at 3 and 12months...
November 15, 2016: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/27753916/os-03-08-efficacy-of-telmisartan-40%C3%A2-mg-t40-and-hydrochlorothiazide-25%C3%A2-mg-h25-monotherapy-in-high-sodium-intake-patients-with-mild-to-moderate-hypertension-that-study-a-multicenter-randomized-double-blinded-parallel-controlled-trial
#12
Puhong Zhang, Ningling Sun, Hongyi Wang, Lei Sun, Jing Zhang, Yang Xi, Yangfeng Wu, Lijing Yan
OBJECTIVE: To compare the BP lowering effect of ARBs and thiazide diuretics in high sodium intake patients with mild to moderate hypertension. DESIGN AND METHOD: This research was a multicenter randomized double-blinded parallel controlled trial. Eligible participants were randomly divided into T40 and H25 groups, with 3 follow-ups, scheduled on the 15th, 30th and 60th day to compare the difference of average BP decrease, blood pressure control rates, FBG (fast blood glucose), hypokalemia and other adverse events between two groups after intervention...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27753913/os-03-05-effect-of-salt-reduction-on-iodine-status-assessed-by-24%C3%A2-h-urinary-iodine-excretion-in-children-and-their-families-in-northern-china-a-cluster-randomised-controlled-trial
#13
Feng He, Yuan Ma, Xiangxian Feng, Wanqi Zhang, Laixiang Lin, Xiaohui Guo, Jing Zhang, Wenyi Niu, Yangfeng Wu, Graham MacGregor
OBJECTIVE: To study the effect of salt reduction on iodine status and to determine whether iodine consumption was still adequate after salt intake was reduced by ≈25% in northern China where universal salt iodisation is mandatory. DESIGN AND METHOD: We measured 24 h urinary iodine in individuals who participated in School-EduSalt (School-based Education Programme to Reduce Salt), a cluster randomised controlled trial in 28 primary schools (279 children, age 10...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27753912/os-03-04-influence-of-family-and-peer-networks-on-salt-reduction-in-children-in-the-school-edusalt-school-based-education-programme-to-reduce-salt-trial
#14
Yuan Ma, Xiangxian Feng, Jing Zhang, Haijun Wang, Jianhui Yuan, Zhifang Li, Yanbo Han, Jianbin Zhang, Feng J He, Graham MacGregor, Yangfeng Wu
OBJECTIVE: To identify the social determinants shaping children's behaviour on salt reduction from a network perspective. DESIGN AND METHOD: School-EduSalt is a cluster-randomized controlled trial carried out in 28 primary schools in northern China involving 279 families (279 children aged 10.1 ± 0.5yrs and 553 adults). A 3.5-month education on salt reduction was delivered to the 14 schools (classes) in the intervention group, of which children and their families achieved a significant reduction in salt intake as measured by 24-hour urine sodium...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27670515/effect-of-salt-reduction-on-iodine-status-assessed-by-24%C3%A2-hour-urinary-iodine-excretion-in-children-and-their-families-in-northern-china-a-substudy-of-a-cluster-randomised-controlled-trial
#15
Feng J He, Yuan Ma, Xiangxian Feng, Wanqi Zhang, Laixiang Lin, Xiaohui Guo, Jing Zhang, Wenyi Niu, Yangfeng Wu, Graham A MacGregor
OBJECTIVE: To study the effect of salt reduction on iodine status and to determine whether iodine consumption was still adequate after salt reduction in a population where universal salt iodisation is mandatory. DESIGN: A substudy of a cluster randomised controlled trial, with schools randomly assigned to either the intervention or the control group. SETTING: 28 primary schools in Changzhi, northern China. PARTICIPANTS: 279 children in grade 5 of primary school (mean age: 10...
September 26, 2016: BMJ Open
https://www.readbyqxmd.com/read/27643280/os-03-08-efficacy-of-telmisartan-40%C3%A2-mg-t40-and-hydrochlorothiazide-25%C3%A2-mg-h25-monotherapy-in-high-sodium-intake-patients-with-mild-to-moderate-hypertension-that-study-a-multicenter-randomized-double-blinded-parallel-controlled-trial
#16
Puhong Zhang, Ningling Sun, Hongyi Wang, Lei Sun, Jing Zhang, Yang Xi, Yangfeng Wu, Lijing Yan
OBJECTIVE: To compare the BP lowering effect of ARBs and thiazide diuretics in high sodium intake patients with mild to moderate hypertension. DESIGN AND METHOD: This research was a multicenter randomized double-blinded parallel controlled trial. Eligible participants were randomly divided into T40 and H25 groups, with 3 follow-ups, scheduled on the 15th, 30th and 60th day to compare the difference of average BP decrease, blood pressure control rates, FBG (fast blood glucose), hypokalemia and other adverse events between two groups after intervention...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27643261/os-03-05-effect-of-salt-reduction-on-iodine-status-assessed-by-24%C3%A2-h-urinary-iodine-excretion-in-children-and-their-families-in-northern-china-a-cluster-randomised-controlled-trial
#17
Feng He, Yuan Ma, Xiangxian Feng, Wanqi Zhang, Laixiang Lin, Xiaohui Guo, Jing Zhang, Wenyi Niu, Yangfeng Wu, Graham MacGregor
OBJECTIVE: To study the effect of salt reduction on iodine status and to determine whether iodine consumption was still adequate after salt intake was reduced by ≈25% in northern China where universal salt iodisation is mandatory. DESIGN AND METHOD: We measured 24 h urinary iodine in individuals who participated in School-EduSalt (School-based Education Programme to Reduce Salt), a cluster randomised controlled trial in 28 primary schools (279 children, age 10...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27643260/os-03-04-influence-of-family-and-peer-networks-on-salt-reduction-in-children-in-the-school-edusalt-school-based-education-programme-to-reduce-salt-trial
#18
Yuan Ma, Xiangxian Feng, Jing Zhang, Haijun Wang, Jianhui Yuan, Zhifang Li, Yanbo Han, Jianbin Zhang, Feng J He, Graham MacGregor, Yangfeng Wu
OBJECTIVE: To identify the social determinants shaping children's behaviour on salt reduction from a network perspective. DESIGN AND METHOD: School-EduSalt is a cluster-randomized controlled trial carried out in 28 primary schools in northern China involving 279 families (279 children aged 10.1 ± 0.5yrs and 553 adults). A 3.5-month education on salt reduction was delivered to the 14 schools (classes) in the intervention group, of which children and their families achieved a significant reduction in salt intake as measured by 24-hour urine sodium...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27626640/impact-of-prior-use-of-four-preventive-medications-on-outcomes-in-patients-hospitalized-for-acute-coronary-syndrome-results-from-cpacs-2-study
#19
Min Li, Yubei Huang, Xin Du, Shenshen Li, Jiachao Ji, Anushka Patel, Runlin Gao, Yangfeng Wu
BACKGROUND: It is widely reported that long-term use of four preventive medications (antiplatelet agents, angiotensin converting enzyme inhibitor / angiotensin receptor blocker, statin and beta-blockers) reduce the risk of subsequent acute coronary syndromes (ACS). It is unclear whether these four medications benefit patients who develop ACS despite its use. METHODS AND RESULTS: Logistic regression and propensity-score was applied among 14790 ACS patients to assess the association between prior use of four preventive medications and in-hospital outcomes including severity of disease at presentation (type of ACS, systolic blood pressure <90 mmHg, and heart rate> = 100 beats/min), complicating arrhythmia and major adverse cardiovascular events (MACEs, including all deaths, non-fatal myocardial infarction or re-infarction, and non-fatal stroke)...
2016: PloS One
https://www.readbyqxmd.com/read/27515930/does-education-level-affect-the-efficacy-of-a-community-based-salt-reduction-program-a-post-hoc-analysis-of-the-china-rural-health-initiative-sodium-reduction-study-crhi-srs
#20
RANDOMIZED CONTROLLED TRIAL
Xin Wang, Xian Li, Ilonca Vaartjes, Bruce Neal, Michiel L Bots, Arno W Hoes, Yangfeng Wu
BACKGROUND: Whether educational level influences the effects of health education is not clearly defined. This study examined whether the impact of a community-based dietary salt reduction program was affected by the level of education of participants. METHODS: The China Rural Health Initiative Sodium Reduction Study (CRHI-SRS) was a cluster-randomized controlled trial conducted in 120 villages from five Northern Chinese provinces. The intervention comprised a village-wide health education program and availability of salt substitute at village shops...
August 11, 2016: BMC Public Health
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