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https://www.readbyqxmd.com/read/28535100/the-national-institutes-of-health-stroke-scale-its-role-in-patients-with-posterior-circulation-stroke
#1
Antonio Siniscalchi, Roman Sztajzel, Giovanni Malferrari, Luca Gallelli
The National Institutes of Health Stroke Scale (NIHSS) is indispensable for both prognosis and treatment in patients with acute ischemic stroke. However, there is subtype of acute ischemic stroke (i.e., posterior circulation stroke) that is difficult to diagnose using the NIHSS. The authors report the limits of NIHSS in this stroke subtype, suggesting thereby the need to modify and render it more appropriate for the evaluation of the neurological signs occurring in posterior circulation stroke.
May 23, 2017: Hospital Topics
https://www.readbyqxmd.com/read/28533683/new-standardized-nursing-cooperation-workflow-to-reduce-stroke-thrombolysis-delays-in-patients-with-acute-ischemic-stroke
#2
Yan Zhou, Zhuojun Xu, Jiali Liao, Fangming Feng, Lai Men, Li Xu, Yanan He, Gang Li
OBJECTIVE: We assessed the effectiveness of a new standardized nursing cooperation workflow in patients with acute ischemic stroke (AIS) to reduce stroke thrombolysis delays. PATIENTS AND METHODS: AIS patients receiving conventional thrombolysis treatment from March to September 2015 were included in the control group, referred to as T0. The intervention group, referred to as T1 group, consisted of AIS patients receiving a new standardized nursing cooperation workflow for intravenous thrombolysis (IVT) at the emergency department of Shanghai East Hospital (Shanghai, People's Republic of China) from October 2015 to March 2016...
2017: Neuropsychiatric Disease and Treatment
https://www.readbyqxmd.com/read/28532498/the-golden-hour-of-acute-ischemic-stroke
#3
Rajiv Advani, Halvor Naess, Martin W Kurz
BACKGROUND: Acute Ischemic Stroke (AIS) treatment has been revolutionised in the last two decades with the increasing use of Intravenous Thrombolysis (IVT) and with the advent of Endovascular therapy (EVT). AIS treatment and outcome are time dependant and time saving measures are being implemented at every step of the treatment chain. These changes have resulted in lower treatment times in-hospital, but it is unclear if this translates into more patients being treated within 60 min of symptom onset - the Golden Hour...
May 22, 2017: Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine
https://www.readbyqxmd.com/read/28526532/significant-elevation-of-serum-caspase-3-levels-in-patients-with-intracerebral-hemorrhage
#4
De-Biao Sun, Meng-Jun Xu, Qing-Meng Chen, Hai-Tao Hu
BACKGROUND: Caspase-3 is a potential marker of apoptosis. We investigated whether serum caspase-3 concentrations were increased and its association with severity and prognosis after intracerebral hemorrhage (ICH). METHODS: This prospective clinical study recruited 112 ICH patients and 112 healthy individuals. Serum was assayed for caspase-3 using enzyme-linked immunosorbent assay. Stroke severity was quantified by National Institute of Health Stroke Scale (NIHSS) and hematoma volume...
May 16, 2017: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/28526531/detection-of-high-serum-concentration-of-cxc-chemokine-ligand-12-in-acute-intracerebral-hemorrhage
#5
Jia Shen, Bin Chen, Guan-Rong Zheng, Shen-Zhong Qiu, Huai-Ming Yin, Wei Mao, Hong-Xiang Wang, Jian-Bo Gao
BACKGROUND: CXC chemokine ligand-12 (CXCL12), a member of the CXC chemokine subfamily, is involved in both focal angiogenesis and inflammatory reactions. We examined serum CXCL12 concentration in intracerebral hemorrhage (ICH) patients and its correlation to stroke severity and outcome. METHODS: The study was carried out on 105 ICH patients on 105 healthy controls. Serum samples were at admission obtained to measure CXCL12 concentrations. The National Institutes of Health Stroke Scale (NIHSS) and hematoma volume were recorded to assess stroke severity...
May 16, 2017: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/28525972/association-of-fibrinogen-level-with-early-neurological-deterioration-among-acute-ischemic-stroke-patients-with-diabetes
#6
Seong-Joon Lee, Ji Man Hong, Sung Eun Lee, Dae Ryong Kang, Bruce Ovbiagele, Andrew M Demchuk, Jin Soo Lee
BACKGROUND: Diabetes mellitus (DM) is a risk factor for early neurological deterioration (END) in acute ischemic stroke. The prothrombotic protein fibrinogen is frequently elevated in patients with diabetes, and may be associated with poorer prognoses. We evaluated whether fibrinogen is associated with END in patients with diabetes after acute ischemic stroke. METHODS: We included 3814 patients from a single hospital database admitted within 72 h of onset of ischemic stroke...
May 19, 2017: BMC Neurology
https://www.readbyqxmd.com/read/28515707/validation-of-repeated-endothelial-function-measurements-using-endopat-in-stroke
#7
Aina S Hansen, Jawad H Butt, Sonja Holm-Yildiz, William Karlsson, Christina Kruuse
BACKGROUND: Decreased endothelial function (EF) may be a prognostic marker for stroke. Measuring pharmacological effects on EF may be of interest in the development of personalized medicine for stroke prevention. In this study, we assessed the reliability of repeated EF measurements using a pulse amplitude tonometry technology in acute stroke patients. Similarly, reliability was tested in healthy subjects devoid of vascular disease to estimate reactivity and reliability in a younger non-stroke population...
2017: Frontiers in Neurology
https://www.readbyqxmd.com/read/28513116/worse-outcome-in-patients-with-acute-stroke-and-atrial-fibrillation-following-thrombolysis
#8
Michael Findler, Jeremy Molad, Natan M Bornstein, Eitan Auriel
BACKGROUND: Atrial fibrillation (AF) is the most common arrhythmia and a common cause of ischemic stroke. Stroke patients with AF have been shown to have a poorer neurological outcome than stroke patients without AF. OBJECTIVES: To determine the impact of pre-existing AF on residual degree of disability in patients treated with IV thrombolysis. METHODS: In this case-control study, data of 214 stroke patients (63 with AF and 151 without AF) were collected from the National Acute Stroke Israeli Registry, a nationwide quadrennial stroke database...
May 2017: Israel Medical Association Journal: IMAJ
https://www.readbyqxmd.com/read/28511144/development-of-a-prognostic-scale-for-severely-hemiplegic-stroke-patients-in-a-rehabilitation-hospital
#9
Yoshitake Hirano, Osamu Nitta, Takeshi Hayashi, Hidetoshi Takahashi, Yasuhiro Miyazaki, Hiroshi Kigawa
OBJECTIVES: For patients with severe hemiplegia in a rehabilitation hospital, early prediction of the functional prognosis and outcomes is challenging. The purpose of this study was to create and verify a prognostic scale in severely hemiplegic stroke patients and allowing for prediction of (1) the ability to walk at the time of hospital discharge, (2) the ability to carry out activities of daily living (ADL), and (3) feasibility of home discharge. PATIENTS AND METHODS: The study was conducted on 80 severely hemiplegic stroke patients...
April 28, 2017: Clinical Neurology and Neurosurgery
https://www.readbyqxmd.com/read/28508117/single-center-experience-using-the-3max-reperfusion-catheter-for-the-treatment-of-acute-ischemic-stroke-with-distal-arterial-occlusions
#10
Kévin Premat, Bruno Bartolini, Flore Baronnet-Chauvet, Eimad Shotar, Vincent Degos, Paul Muresan, Federico Di Maria, Joseph Gabrieli, Charlotte Rosso, Silvia Pistocchi, Jacques Chiras, Nader Sourour, Sonia Alamowitch, Yves Samson, Frédéric Clarençon
PURPOSE: Most recent guidelines recommend the use of stent retriever devices in endovascular treatment of acute ischemic stroke with large vessel occlusion (LVO). Recently published data reported convincing results with thromboaspiration devices such as the Penumbra System (Penumbra, Alameda, CA, USA) combined with supple reperfusion catheters by using the ADAPT (A Direct Aspiration First-Pass Thrombectomy) technique. The aim of this study was to report our initial experience with the 3MAX (3...
May 15, 2017: Clinical Neuroradiology
https://www.readbyqxmd.com/read/28506148/large-scale-phase-synchrony-reflects-clinical-status-after-stroke-an-eeg-study
#11
Teiji Kawano, Noriaki Hattori, Yutaka Uno, Keiichi Kitajo, Megumi Hatakenaka, Hajime Yagura, Hiroaki Fujimoto, Tomomi Yoshioka, Michiko Nagasako, Hironori Otomune, Ichiro Miyai
BACKGROUND AND PURPOSE: Stroke-induced focal brain lesions often exert remote effects via residual neural network activity. Electroencephalographic (EEG) techniques can assess neural network modifications after brain damage. Recently, EEG phase synchrony analyses have shown associations between the level of large-scale phase synchrony of brain activity and clinical symptoms; however, few reports have assessed such associations in stroke patients. OBJECTIVE: The aim of this study was to investigate the clinical relevance of hemispheric phase synchrony in stroke patients by calculating its correlation with clinical status...
June 2017: Neurorehabilitation and Neural Repair
https://www.readbyqxmd.com/read/28505996/depression-one-year-after-hemorrhagic-stroke-is-associated-with-late-worsening-of%C3%A2-outcomes
#12
Sara Stern-Nezer, Irina Eyngorn, Michael Mlynash, Ryan W Snider, Chitra Venkatsubramanian, Christine A C Wijman, Marion S Buckwalter
BACKGROUND: Poststroke depression is the most common psychiatric sequelae of stroke, and it's independently associated with increased morbidity and mortality. Few studies have examined depression after intracranial hemorrhage (ICH). OBJECTIVE: To investigate the relationship between depression, ICH and outcomes. METHODS: A substudy of the prospective Diagnostic Accuracy of MRI in Spontaneous Intracerebral Hemorrhage (DASH) study, we included 89 subjects assessed for depression 1 year after hemorrhage...
May 11, 2017: NeuroRehabilitation
https://www.readbyqxmd.com/read/28503451/association-between-a-polymorphism-in-casp3-and-casp9-genes-and-ischemic-stroke
#13
Bae Youl Lee, Jinmann Chon, Hee-Sang Kim, Jong Ha Lee, Dong Hwan Yun, Seung Don Yoo, Dong Hwan Kim, Seung Ah Lee, Yoo Jin Han, Hyunseok Lee, Jin Chul Kim, Yunsoo Soh, Joo-Ho Chung, Su Kang Kim, Hae Jeong Park
OBJECTIVE: To investigate whether the polymorphisms of CASP3 gene (rs4647602, intron A/C and rs1049216, UTR C/T) and CASP9 gene (rs1052576, Gln/Arg G/A and rs1052571, Ser/Val T/C) were associated with the development, and clinical severity of ischemic stroke and functional consequences after stroke. METHODS: Genomic DNA from 121 ischemic stroke patients and 201 healthy control subjects were extracted, and polymerase chain reaction products were sequenced. To investigate the association of polymorphisms and the development, and National Institutes of Health Stroke Scale (K-NIHSS), logistic regression models were analyzed...
April 2017: Annals of Rehabilitation Medicine
https://www.readbyqxmd.com/read/28495947/mechanical-thrombectomy-with-the-embolus-retriever-with-interlinked-cages-in-acute-ischemic-stroke-eric-the-new-boy-in-the-class
#14
H Steglich-Arnholm, D Kondziella, A Wagner, M E Cronqvist, K Hansen, T C Truelsen, L-H Krarup, J L S Højgaard, S Taudorf, H K Iversen, D W Krieger, M Holtmannspötter
BACKGROUND AND PURPOSE: The Embolus Retriever with Interlinked Cages (ERIC) device is a novel stent retriever for mechanical thrombectomy. It consists of interlinked cages and could improve procedural benchmarks and clinical outcome compared with classic stent retrievers. This study compares the rates of recanalization, favorable clinical outcome, procedural adverse events, and benchmarks between the ERIC device and classic stent retrievers. MATERIALS AND METHODS: From 545 patients treated with thrombectomy between 2012 and 2015, 316 patients were included...
May 11, 2017: AJNR. American Journal of Neuroradiology
https://www.readbyqxmd.com/read/28495141/association-of-lower-serum-brain-derived-neurotrophic-factor-levels-with-larger-infarct-volumes-in-acute-ischemic-stroke
#15
Hui-Jie Qiao, Zhen-Zhi Li, Li-Ming Wang, Wei Sun, Jin-Chao Yu, Bin Wang
OBJECTIVE: Brain-derived neurotrophic factor (BDNF) plays a potential role in stroke recovery, as it promotes plasticity. The aim of this study is to investigate the association between infarct volume using DWI and BDNF at admission in patients with acute ischemic stroke (AIS). METHODS: The study population comprised consecutive patients with an AIS diagnosis who had been referred to our hospital between January 2015 and June 2016. The severity of stroke was evaluated by the National Institutes of Health Stroke Scale (NIHSS) at admission...
June 15, 2017: Journal of Neuroimmunology
https://www.readbyqxmd.com/read/28494694/antagonizing-dabigatran-by-idarucizumab-in-cases-of-ischemic-stroke-or-intracranial-hemorrhage-in-germany-a-national-case-collection
#16
Pawel Kermer, Christoph C Eschenfelder, Hans-Christoph Diener, Martin Grond, Yasser Abdalla, Katharina Althaus, Jörg Berrouschot, Hakan Cangür, Michael Daffertshofer, Sebastian Edelbusch, Klaus Gröschel, Claus G Haase, Andreas Harloff, Valentin Held, Andreas Kauert, Peter Kraft, Arne Lenz, Wolfgang Müllges, Mark Obermann, Someieh Partowi, Jan Purrucker, Peter A Ringleb, Joachim Röther, Raluca Rossi, Niklas Schäfer, Andreas Schneider, Ramona Schuppner, Rüdiger J Seitz, Kristina Szabo, Robert Wruck
Background Idarucizumab is a monoclonal antibody fragment with high affinity for dabigatran that reverses its anticoagulant effects within minutes. It may exhibit the potential for patients under dabigatran therapy suffering ischemic stroke to regain eligibility for thrombolysis with rt-PA and may inhibit lesion growth in patients with intracerebral hemorrhage on dabigatran. Aims To provide insights into the clinical use of idarucizumab in patients under effective dabigatran anticoagulation presenting with signs of ischemic stroke or intracranial hemorrhage...
June 2017: International Journal of Stroke: Official Journal of the International Stroke Society
https://www.readbyqxmd.com/read/28487333/enhanced-detection-of-edema-in-malignant-anterior-circulation-stroke-edema-score-a-risk-prediction-tool
#17
Charlene Jennifer Ong, Jeffrey Gluckstein, Osvaldo Laurido-Soto, Yan Yan, Rajat Dhar, Jin-Moo Lee
BACKGROUND AND PURPOSE: Rapid recognition of those at high risk for malignant edema after stroke would facilitate triage for monitoring and potential surgery. Admission data may be insufficient for accurate triage decisions. We developed a risk prediction score using clinical and radiographic variables within 24 hours of ictus to better predict potentially lethal malignant edema. METHODS: Patients admitted with diagnosis codes of cerebral edema and ischemic stroke, NIHSS score (National Institute of Health Stroke Score) of ≥8 and head computed tomographies within 24 hours of stroke onset were included...
May 9, 2017: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/28486789/ct-perfusion-to-predict-response-to-recanalization-in-ischemic-stroke
#18
Maarten G Lansberg, Soren Christensen, Stephanie Kemp, Michael Mlynash, Nishant Mishra, Christian Federau, Jenny P Tsai, Sun Kim, Raul G Nogueria, Tudor Jovin, Thomas G Devlin, Naveed Akhtar, Dileep R Yavagal, Diogo Haussen, Seena Dehkharghani, Roland Bammer, Matus Straka, Greg Zaharchuk, Michael P Marks, Gregory W Albers
OBJECTIVE: To assess the utility of CT perfusion for selection of patients for endovascular therapy up to 18 hours after symptom onset. METHODS: We conducted a multicenter cohort study of consecutive acute stroke patients scheduled to undergo endovascular therapy within 90 min after a baseline CTP. Patients were classified as 'target mismatch' if they had a small ischemic core and a large penumbra on their baseline CT perfusion. Reperfusion was defined as >50% reduction in critical hypoperfusion between the baseline CT perfusion and the 36-hour follow-up MRI...
May 9, 2017: Annals of Neurology
https://www.readbyqxmd.com/read/28485774/the-clinical-study-on-the-treatment-for-acute-cerebral-infarction-by-intra-arterial-thrombolysis-combined-with-mild-hypothermia
#19
L-L Ma, L Song, X-D Yu, T-X Yu, H Liang, J-X Qiu, L Tan
OBJECTIVE: This study was purposed to evaluate the clinical efficacy of the treatment for acute cerebral infarction by intra-arterial thrombolysis combined with mild hypothermia. PATIENTS AND METHODS: Thirty patients, diagnosed with acute anterior circulation cerebral infarction and admitted to the Hospital between January 2013 and September 2015, were randomly divided into the control group and the mild hypothermia group, each group comprising 15 cases. The treatment of intra-arterial thrombolysis combined with mild hypothermia was administered to the mild hypothermia group, while only the treatment of intra-arterial thrombolysis was performed on the control group...
April 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28481164/diffuse-microvascular-dysfunction-and-loss-of-white-matter-integrity-predict-poor-outcomes-in-patients-with-acute-ischemic-stroke
#20
Natalia S Rost, Pedro Cougo, Svetlana Lorenzano, Hua Li, Lisa Cloonan, Mark Jrj Bouts, Arne Lauer, Mark R Etherton, Hasan H Karadeli, Patricia L Musolino, William A Copen, Ken Arai, Eng H Lo, Steve K Feske, Karen L Furie, Ona Wu
We sought to investigate the relationship between blood-brain barrier (BBB) permeability and microstructural white matter integrity, and their potential impact on long-term functional outcomes in patients with acute ischemic stroke (AIS). We studied 184 AIS subjects with perfusion-weighted MRI (PWI) performed <9 h from last known well time. White matter hyperintensity (WMH), acute infarct, and PWI-derived mean transit time lesion volumes were calculated. Mean BBB leakage rates (K2 coefficient) and mean diffusivity values were measured in contralesional normal-appearing white matter (NAWM)...
January 1, 2017: Journal of Cerebral Blood Flow and Metabolism
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