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https://www.readbyqxmd.com/read/28816573/a-longitudinal-study-investigating-how-stroke-severity-disability-and-physical-function-the-first-week-post-stroke-are-associated-with-walking-speed-six-months-post-stroke
#1
Mona Kristin Aaslund, Rolf Moe-Nilssen, Bente Bassøe Gjelsvik, Bård Bogen, Halvor Næss, Håkon Hofstad, Jan Sture Skouen
OBJECTIVES: To investigate to which degree stroke severity, disability, and physical function the first week post-stroke are associated with preferred walking speed (PWS) at 6 months. DESIGN: Longitudinal observational study. METHOD: Participants were recruited from a stroke unit and tested within the first week (baseline) and at 6 months post-stroke. Outcome measures were the National Institutes of Health Stroke Scale (NIHSS), the Barthel Index (BI), modified Rankin Scale (mRS), PWS, Postural Assessment Scale for Stroke (PASS), and the Trunk Impairment Scale modified-Norwegian version...
August 17, 2017: Physiotherapy Theory and Practice
https://www.readbyqxmd.com/read/28812045/soluble-st2-predicts-outcome-and-hemorrhagic-transformation-after-acute-stroke
#2
Zoe Wolcott, Ayush Batra, Matthew B Bevers, Cristina Sastre, Jane Khoury, Matthew Sperling, Brett C Meyer, Kyle B Walsh, Opeolu Adeoye, Joseph P Broderick, W Taylor Kimberly
OBJECTIVE: ST2 is a member of the toll-like receptor superfamily that can alter inflammatory signaling of helper T-cells. We investigated whether soluble ST2 (sST2) could independently predict outcome and hemorrhagic transformation (HT) in the setting of stroke. METHODS: We measured sST2 in patients enrolled in the Specialized Program of Translational Research in Acute Stroke (SPOTRIAS) network biomarker study. 646 patients had plasma samples collected at the time of hospital admission and 210 patients had a second sample collected 48 h after stroke onset...
August 2017: Annals of Clinical and Translational Neurology
https://www.readbyqxmd.com/read/28804679/time-to-neurological-deterioration-in-ischemic-stroke
#3
James E Siegler, Karen C Albright, Alexander J George, Amelia K Boehme, Michael A Gillette, Andre D Kumar, Monica Aswani, Sheryl Martin-Schild
BACKGROUND: Neurological deterioration (ND) is common, with nearly one-half of ND patients deteriorating within the first 24 to 48 hours of stroke. The timing of ND with respect to ND etiology and reversibility has not been investigated. METHODS: At our center, we define ND as an increase of 2 or more points in the National Institutes of Health Stroke Scale (NIHSS) score within 24 hours and categorize etiologies of ND according to clinical reversibility. ND etiologies were considered non-reversible if such causes may have produced or extended any areas of ischemic neurologic injury due to temporary or permanent impairment in cerebral perfusion...
2017: Medical Student Research Journal
https://www.readbyqxmd.com/read/28804453/delta-power-is-higher-and-more-symmetrical-in-ischemic-stroke-patients-with-cortical-involvement
#4
Chiara Fanciullacci, Federica Bertolucci, Giuseppe Lamola, Alessandro Panarese, Fiorenzo Artoni, Silvestro Micera, Bruno Rossi, Carmelo Chisari
A brain injury resulting from unilateral stroke critically alters brain functionality and the complex balance within the cortical activity. Such modifications may critically depend on lesion location and cortical involvement. Indeed, recent findings pointed out the necessity of applying a stratification based on lesion location when investigating inter-hemispheric balance in stroke. Here, we tested whether cortical involvement could imply differences in band-specific activity and brain symmetry in post stroke patients with cortico-subcortical and subcortical strokes...
2017: Frontiers in Human Neuroscience
https://www.readbyqxmd.com/read/28803427/unknown-onset-ischemic-strokes-in-patients-last-seen-well-4-5%C3%A2-h-differences-between-wake-up-and-daytime-unwitnessed-strokes
#5
Luuk Dekker, Hajo Hund, Robin Lemmens, Jelis Boiten, Ido van den Wijngaard
Patients with unknown time of stroke onset (UOS) represent around one-third of ischemic stroke patients. These are patients with wake-up stroke (WUS) or daytime-unwitnessed stroke (DUS), often presenting outside the time-window for reperfusion therapy. UOS patients presenting between 4.5 and 12 h after time of last-seen-well were included. Clinical and imaging characteristics were compared between WUS and DUS patients. Good functional outcome was defined as a modified Rankin scale of ≤2 at follow-up. Sixty-one UOS patients were included: 42 WUS and 19 DUS patients...
August 12, 2017: Acta Neurologica Belgica
https://www.readbyqxmd.com/read/28801883/prognostic-utility-of-fatty-acid-binding-protein-4-in-patients-with-type-2-diabetes-and-acute-ischemic-stroke
#6
Siou Li, Pengxiang Bi, Weina Zhao, Yifei Lian, Haifu Zhu, Dan Xu, Jiayuan Ding, Quankui Wang, Changhao Yin
The role of fatty acid-binding proteins (FABPs) in atherosclerosis has been investigated. The aim of this study was to verify the hypothesis that higher levels of serum fatty acid-binding protein 4 (FABP4) could be a prognostic factor in Chinese patients with type 2 diabetes (T2DM) and acute ischemic stroke (AIS). From September 2015 to August 2016, consecutive first-ever AIS patients combined with T2DM were included in this study. FABP4, NIH stroke scale (NIHSS), and conventional risk factors were evaluated to determine their value to predict functional outcomes within 3 months...
August 11, 2017: Neurotoxicity Research
https://www.readbyqxmd.com/read/28799181/the-relationship-between-stroke-severity-and-prior-direct-oral-anticoagulant-therapy-in-patients-with-acute-ischemic-stroke-and-non-valvular-atrial-fibrillation
#7
Yuki Sakamoto, Seiji Okubo, Chikako Nito, Satoshi Suda, Noriko Matsumoto, Arata Abe, Junya Aoki, Takashi Shimoyama, Yohei Takayama, Kentaro Suzuki, Masahiro Mishina, Kazumi Kimura
BACKGROUND: Anticoagulant treatment with a vitamin K antagonist (VKA) has been reported to reduce stroke severity when patients with atrial fibrillation (AF) suffer acute ischemic stroke (AIS). Direct oral anticoagulant (DOAC) therapy also has a potential to reduce the initial severity of AIS. However, the effect of DOAC therapy on the severity of AIS is not well known. The aims of the present study were to investigate the effect of DOACs on initial stroke severity in patients with AIS and non-valvular AF (NVAF)...
August 11, 2017: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
https://www.readbyqxmd.com/read/28783808/recrudescence-of-deficits-after-stroke-clinical-and-imaging-phenotype-triggers-and-risk-factors
#8
Mehmet A Topcuoglu, Esen Saka, Scott B Silverman, Lee H Schwamm, Aneesh B Singhal
Importance: Reemergence of previous stroke-related deficits (or poststroke recrudescence [PSR]) is an underrecognized and inadequately characterized phenomenon. Objective: To investigate the clinical features, triggers, and risk factors for PSR. Design, Setting, and Participants: This retrospective study incorporated a crossover cohort study to identify triggers and a case-control study to identify risk factors. The study used the Massachusetts General Hospital Research Patient Data Repository to identify patients for the period January 1, 2000, to November 30, 2015, who had a primary or secondary diagnosis of cerebrovascular disease, who underwent magnetic resonance imaging of the brain at least once, and whose inpatient or outpatient clinician note or discharge summary stated the term recrudescence...
August 7, 2017: JAMA Neurology
https://www.readbyqxmd.com/read/28783210/monocyte-count-at-onset-predicts-post-stroke-outcomes-during-a-90-day-follow-up
#9
Luca Liberale, Fabrizio Montecucco, Aldo Bonaventura, Ilaria Casetta, Silva Seraceni, Alessandro Trentini, Marina Padroni, Franco Dallegri, Enrico Fainardi, Federico Carbone
BACKGROUND: Acute ischemic stroke (AIS) triggers both systemic and neurovascular inflammation, influencing post-stroke recovery. In smokers with AIS inflammation might be further upregulated, increasing ischemia/reperfusion injury. Here, the predictive value of leukocyte and adhesion molecules levels on post-stroke outcomes was investigated. MATERIALS AND METHODS: 89 patients with AIS (n=30 smokers and n=59 non-smokers) were recruited and evaluated 1, 7 and 90 days after the onset to assess stroke severity by the National Institute of Health Stroke Scale (NIHSS) score as well as clinical recovery at 90 day by the modified Rankin Scale (mRS)...
August 7, 2017: European Journal of Clinical Investigation
https://www.readbyqxmd.com/read/28781090/fatty-acid-binding-protein-4-is-associated-with-stroke-risk-and-severity-in-patients-with-acute-ischemic-stroke
#10
Li Chang, Jianlong Zhang, Li Liu, Zhen Huang, Yingbo Han, Yanyan Zhu
OBJECTIVE: The role of fatty acid-binding proteins (FABPs) in atherosclerosis has been investigated. The aim of this study was to verify the hypothesis that higher levels of serum FABP4 could be a biomarker for stroke and associated with stroke severity in Chinese patients with ischemic stroke. METHODS: All consecutive patients with first-ever acute ischemic stroke from September 2015 to August 2016 were recruited to participate in the study. Serum FABP4 levels and routine tests were examined at admission...
July 19, 2017: Journal of Neuroimmunology
https://www.readbyqxmd.com/read/28780251/convexity-subarachnoid-hemorrhage-due-to-cardioembolic-stroke-in-a-woman-with-thyrotoxicosis-%C3%AE-case-report
#11
Ioanna Spanou, Sophia Vassilopoulou, Eleni Koroboki, Argyro Tountopoulou, Georgios Velonakis, Dimos Dimitrios Mitsikostas
BACKGROUND: Non-traumatic convexity subarachnoid hemorrhage (cSAH) is a rarely reported condition with a wide spectrum of etiologies. Cerebral ischemia secondary to extracranial or intracranial atherosclerotic disease has been identified as a relatively uncommon cause of cSAH. CASE REPORT: We report a case of cSAH caused by cardioembolic stroke. A 69-year old female patient developed suddenly left-sided face and body weakness and numbness and visual neglect on the left...
August 2, 2017: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
https://www.readbyqxmd.com/read/28770947/clinical-study-on-anti-epileptic-drug-with-b-vitamins-for-the-treatment-of-epilepsy-after-stroke
#12
H Zhou, N Wang, L Xu, H-L Huang, C-Y Yu
OBJECTIVE: To study the clinical value of anti-epileptic drugs combined with B vitamins in the treatment of epilepsy after stroke. PATIENTS AND METHODS: The study included 90 consecutive patients with epilepsy after stroke. Patients were randomly divided into groups of 30 each according to treatment: single-agent or combination anti-epileptic therapy with oxcarbazepine and sodium valproate (control group), anti-epileptic therapy with compound vitamin B tablets (observation group 1), and anti-epileptic therapy with vitamin B12 (mecobalamin) (observation group 2)...
July 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28768820/thrombectomy-versus-medical-management-for-large-vessel-occlusion-strokes-with-minimal-symptoms-an-analysis-from-stopstroke-and-gestor-cohorts
#13
Diogo C Haussen, Fabricio O Lima, Mehdi Bouslama, Jonathan A Grossberg, Gisele S Silva, Michael H Lev, Karen Furie, Walter Koroshetz, Michael R Frankel, Raul G Nogueira
INTRODUCTION: It remains unclear whether patients presenting with large vessel occlusion strokes and mild symptoms benefit from thrombectomy. OBJECTIVE: To compare outcomes of endovascular therapy versus medical management in patients with large vessel occlusion strokes and National Institute of Health Stroke Scale (NIHSS) score ≤5. METHODS: This was a retrospective analysis combining two large prospectively collected datasets including patients with (1) admission NIHSS score ≤5, (2) premorbid modified Rankin Scale (mRS) score 0-2, and (3) middle cerebral-M1/M2, intracranial carotid, anterior cerebral or basilar artery occlusions...
August 2, 2017: Journal of Neurointerventional Surgery
https://www.readbyqxmd.com/read/28763550/effect-of-endovascular-contact-aspiration-vs-stent-retriever-on-revascularization-in-patients-with-acute-ischemic-stroke-and-large-vessel-occlusion-the-aster-randomized-clinical-trial
#14
RANDOMIZED CONTROLLED TRIAL
Bertrand Lapergue, Raphael Blanc, Benjamin Gory, Julien Labreuche, Alain Duhamel, Gautier Marnat, Suzana Saleme, Vincent Costalat, Serge Bracard, Hubert Desal, Mikael Mazighi, Arturo Consoli, Michel Piotin
Importance: The benefits of endovascular revascularization using the contact aspiration technique vs the stent retriever technique in patients with acute ischemic stroke remain uncertain because of lack of evidence from randomized trials. Objective: To compare efficacy and adverse events using the contact aspiration technique vs the standard stent retriever technique as a first-line endovascular treatment for successful revascularization among patients with acute ischemic stroke and large vessel occlusion...
August 1, 2017: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/28763432/endovascular-treatment-of-acute-ischemic-stroke-under-general-anesthesia-predictors-of-good-outcome
#15
Umeshkumar Athiraman, Ali Sultan-Qurraie, Bala Nair, David L Tirschwell, Basavaraj Ghodke, Adam D Havenon, Danial K Hallam, Louis J Kim, Kyra J Becker, Deepak Sharma
BACKGROUND: The choice of anesthetic technique, general anesthesia (GA) versus Monitored Anesthesia Care, may impact the outcome of patients undergoing endovascular treatment of acute ischemic stroke (AIS). The aim of this study was to identify the factors associated with good discharge outcome in patients receiving GA for AIS. MATERIALS AND METHODS: Electronic medical records of patients above 18 years old who underwent endovascular treatment of AIS under GA at a Comprehensive Stroke Center from 2010 to 2014 were reviewed...
July 31, 2017: Journal of Neurosurgical Anesthesiology
https://www.readbyqxmd.com/read/28758075/stroke-impact-scale-3-0-reliability-and-validity-evaluation-of-the-korean-version
#16
Seong Uk Choi, Hye Sun Lee, Joon Ho Shin, Seung Hee Ho, Mi Jung Koo, Kyoung Hae Park, Jeong Ah Yoon, Dong Min Kim, Jung Eun Oh, Se Hwa Yu, Dong A Kim
OBJECTIVE: To establish the reliability and validity the Korean version of the Stroke Impact Scale (K-SIS) 3.0. METHODS: A total of 70 post-stroke patients were enrolled. All subjects were evaluated for general characteristics, Mini-Mental State Examination (MMSE), the National Institutes of Health Stroke Scale (NIHSS), Modified Barthel Index, Hospital Anxiety and Depression Scale (HADS). The SF-36 and K-SIS 3.0 assessed their health-related quality of life. Statistical analysis after evaluation, determined the reliability and validity of the K-SIS 3...
June 2017: Annals of Rehabilitation Medicine
https://www.readbyqxmd.com/read/28752508/safety-and-effectiveness-of-intravenous-thrombolysis-for-acute-ischemic-stroke-outside-the-coverage-of-national-health-insurance-in-taiwan
#17
Yu-Hsiang Su, Chih-Hung Chen, Huey-Juan Lin, Yu-Wei Chen, Mei-Chiun Tseng, Han-Chieh Hsieh, Chih-Hung Chen, Sheng-Feng Sung
PURPOSE: Only a small percentage of ischemic stroke patients were treated with intravenous thrombolysis in Taiwan, partly because of the narrow reimbursement criteria of the National Health Insurance (NHI). We aimed to assess the safety and effectiveness of intravenous thrombolysis not covered by the NHI. METHODS: This is a retrospective analysis of register data from four hospitals. All patients who received intravenous tissue plasminogen activator and fulfilled the American Heart Association/American Stroke Association (AHA/ASA) thrombolysis guidelines between January 2007 and June 2012 were distinguished into two groups: those in accordance (reimbursement group) and those not in accordance (non-reimbursement group) with the NHI reimbursement criteria...
March 15, 2017: Acta Neurologica Taiwanica
https://www.readbyqxmd.com/read/28748994/-intravenous-thrombolysis-for-acute-ischemic-stroke-a-four-years%C3%A2-experience-in-a-chilean-public-hospital
#18
Álvaro Soto V, Gladys Morales I, Marcela Grandjean B, Débora Pollak W, Carolina Del Castillo C, Pía García F, Alexis Von Johnn A, Alfonso Riquelme G
BACKGROUND: Intravenous thrombolysis (IVT) with alteplase (tissue plasminogen activator) is the standard pharmacological treatment in acute ischemic stroke (AIS), reducing disability in patients. AIM: To report the results a thrombolysis protocol during four years in a regional public hospital. MATERIAL AND METHODS: Data from 106 consecutive patients aged 68 ± 13 years (57% men) who were treated with IVT, from May 2012 until April 2016, was analyzed...
April 2017: Revista Médica de Chile
https://www.readbyqxmd.com/read/28746179/the-efficacy-and-safety-of-dl-3n-butylphthalide-on-progressive-cerebral-infarction-a-randomized-controlled-strobe-study
#19
RANDOMIZED CONTROLLED TRIAL
Chenhao Zhang, Shuqin Zhao, Yanjing Zang, Fang Gu, Shufang Mao, Shanshan Feng, Lei Hu, Chunliang Zhang
Progressive cerebral infarction (PCI) is associated with high rates of mortality and disability. Many studies have shown that Dl-3n-butylphthalide (NBP) is effective against acute ischemic stroke. The administration of NBP can result in an increased number of capillaries in the ischemic region, promote the establishment of collateral circulation, protect the mitochondria, and narrow the infarction area, among other effects. In the present study, we evaluated the efficacy and safety of NBP for the treatment of PCI...
July 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28745701/-early-reconstruction-of-brachiocephalic-arteries-as-a-prevention-of-recurrent-ischemic-stroke
#20
A I Khripun, A V Salikov, A D Pryamikov, A B Mironkov, S A Asratyan, M V Abashin, V P Mikhailenko
AIM: To assess an efficacy and safety of brachiocephalic arteries reconstruction at the acute stage of stroke. MATERIAL AND METHODS: Early reconstruction of brachiocephalic arteries was made in 7 patients (mean age 67±9 years). Mean terms of brachiocephalic arteries reconstruction after stroke were 4.6 days (range 2-7 days). Pre- and postoperative neurological state was assessed by NIHSS score (mean preoperative score was 3.9±2.7 in these 7 patients, range 0-7)...
2017: Khirurgiia
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