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https://www.readbyqxmd.com/read/29470997/predictors-of-favorable-outcome-after-mechanical-thrombectomy-for-anterior-circulation-acute-ischemic-stroke-in-octogenarians
#1
Matthias Barral, Louis Lassalle, Cyril Dargazanli, Mikael Mazighi, Hocine Redjem, Raphael Blanc, Georges Rodesch, Bertrand Lapergue, Michel Piotin
INTRODUCTION: Mechanical thrombectomy for anterior circulation large vessel occlusion (LVO) improves functional outcome at three months. This therapeutic approach is the new gold standard, with a benefit being also observed in elderly patients. However, data are limited in this heterogeneous and fragile population. The objectives of this study were, first, to describe outcome after mechanical thrombectomy in a representative group of patients over 80. Second, to evaluate factors associated with a favorable functional outcome after thrombectomy for anterior circulation LVO in elderly patients (aged≥ 80 years)...
February 19, 2018: Journal of Neuroradiology. Journal de Neuroradiologie
https://www.readbyqxmd.com/read/29468632/autonomic-function-test-in-progressive-lacunar-infarction
#2
S Y Ha, K M Park, J Park, S E Kim, B I Lee, K J Shin
OBJECTIVE: Neurological progression is a major problem in managing the patients with acute lacunar infarction. The purpose of this was to investigate whether autonomic dysfunction is associated with neurological progression in patients with acute lacunar infarction. MATERIALS AND METHODS: The study comprised 60 patients with acute lacunar infarction. All enrolled subjects underwent autonomic function tests including the 30° head-up tilt test, Valsalva test, heart rate response to deep breathing, and sympathetic skin response...
February 21, 2018: Acta Neurologica Scandinavica
https://www.readbyqxmd.com/read/29467716/tissue-is-more-important-than-time-in-stroke-patients-being-assessed-for-thrombolysis
#3
Andrew Bivard, Neil Spratt, Ferdinand Miteff, Christopher Levi, Mark William Parsons
Aim: The relative prognostic importance of modern imaging profiles compared with standard clinical characteristics is uncertain in acute stroke patients. In this study, we aimed to compare baseline multimodal CT imaging measures with known clinical predictors of patient outcome at 3 months [modified Rankin scale (mRS)]. Methods: We collected baseline, 24 h, and day 90 clinical and imaging data from acute ischemic stroke patients being assessed for thrombolytic therapy between 2010 and 2015 at a single center as part of a retrospective analysis...
2018: Frontiers in Neurology
https://www.readbyqxmd.com/read/29464140/a-case-report-of-recombinant-tissue-plasminogen-activator-use-in-a-span-100-positive-geriatric-patient-with-thrombocytopenia
#4
Ilya Bragin, Justine M Chen
Thrombocytopenia (platelet count: < 100,000/mm3 ) is considered a contraindication in the use of intravenous thrombolysis for acute ischemic stroke. Little literature exists regarding tissue plasminogen activator (tPA) usage in thrombocytopenic patients, especially in older patients. Age and stroke severity are major prognostic indicators of the risk of hemorrhagic transformation. The Stroke Prognostication using Age and NIH Stroke Scale (SPAN) index estimates a patient's risk of intracerebral hemorrhage (ICH) and clinical response to thrombolysis by combining age in years with the National Institutes of Health Stroke Scale (NIHSS) scores...
December 11, 2017: Curēus
https://www.readbyqxmd.com/read/29456567/influence-of-blood-glucose-level-on-the-prognosis-of-patients-with-diabetes-mellitus-complicated-with-ischemic-stroke
#5
REVIEW
Xiao-Liu Dong, Fei Guan, Shi-Jun Xu, Li-Xia Zhu, Pan-Pan Zhang, Ai-Bin Cheng, Tie-Jun Liu
We carried out this meta-analysis for the aim of exploring the influence of diabetes mellitus (DM) on the prognosis of patients with ischemic stroke. Relevant studies were identified using computerized databases supplemented with manual search strategies. The included studies were strictly followed the inclusion and exclusion criteria. Case-control studies which related to the influence of DM on the prognosis of patients with ischemic stroke were selected. Statistical analyses were implemented with the STATA version 12...
2018: Journal of Research in Medical Sciences: the Official Journal of Isfahan University of Medical Sciences
https://www.readbyqxmd.com/read/29455362/predicting-functional-outcomes-of-posterior-circulation-acute-ischemic-stroke-in-first-36-h-of-stroke-onset
#6
Sheng-Feng Lin, Chin-I Chen, Han-Hwa Hu, Chyi-Huey Bai
Posterior circulation acute ischemic stroke constitutes one-fourth of all ischemic strokes and can be efficiently quantified using the posterior circulation Alberta stroke program early computed tomography score (PC-ASPECTS) through diffusion-weighted imaging. We investigated whether the PC-ASPECTS and National Institutes of Health Stroke Scale (NIHSS) facilitate functional outcome prediction among Chinese patients with posterior circulation acute ischemic stroke. Participants were selected from our prospective stroke registry from January 1, 2015, to December 31, 2016...
February 17, 2018: Journal of Neurology
https://www.readbyqxmd.com/read/29453980/virtual-reality-for-upper-limb-rehabilitation-in-sub-acute-and-chronic-stroke-a-randomized-controlled-trial
#7
Pawel Kiper, Andrzej Szczudlik, Michela Agostini, Jozef Opara, Roman Nowobilski, Laura Ventura, Paolo Tonin, Andrea Turolla
OBJECTIVE: To evaluate the effectiveness of reinforced feedback in virtual environment (RFVE) treatment combined with conventional rehabilitation (CR) in comparison with CR alone, and to study whether changes are related to stroke aetiology (i.e. ischemic or hemorrhagic). DESIGN: Randomized controlled trial. SETTING: Inpatients in a hospital facility for intensive rehabilitation. PARTICIPANTS: 136 patients within one year from onset of a single stroke...
February 14, 2018: Archives of Physical Medicine and Rehabilitation
https://www.readbyqxmd.com/read/29450625/mechanical-thrombectomy-in-patients-with-acute-ischemic-stroke-on-anticoagulation-therapy
#8
David Černík, Daniel Šaňák, Petra Divišová, Martin Köcher, Filip Cihlář, Jana Zapletalová, Tomáš Veverka, Andrea Prcúchová, Dušan Ospalík, Marie Černá, Petra Janoušová, Michal Král, Tomáš Dorňák, Vojtěch Prášil, David Franc, Petr Kaňovský
INTRODUCTION/PURPOSE: Mechanical thrombectomy (MT) for acute ischemic stroke (IS) can be performed also in patients on anticoagulation therapy (AT); however, sufficient and reliable data about safety and efficacy of MT are still missing. Thus, we aimed to compare these parameters between patients treated on AT and without AT. MATERIALS AND METHODS: All consecutive IS patients treated with MT using stent retrievers were included in the retrospective analysis. Neurological deficit was scored using National Institutes of Health Stroke Scale (NIHSS) and 90-day clinical outcome using modified Rankin scale with a score 0-2 for good outcome...
February 15, 2018: Cardiovascular and Interventional Radiology
https://www.readbyqxmd.com/read/29445434/primary-endovascular-treatment-of-acute-ischemic-stroke-using-stent-retrievers-initial-egyptian-experience
#9
Ossama Yassin Mansour, Abdulrahman Mostafa Ibrahim Ali, Mohamed Megahed
Background: Several mechanical thrombectomy (MT) devices have been designed with the goal of improving the recanalization rates of major intracranial artery occlusions. Objective: In this single-center experience, we analyzed the acute ischemic stroke (AIS) treatment with Primary MT; safety and efficacy and clinical results in our patients with large vessel occlusion (LVO). Methods: During a five-year period (from September 2011 to July 2016), out of 996 patients who presented to our center with a diagnosis of AIS, 113 (11...
December 2017: Journal of Vascular and Interventional Neurology
https://www.readbyqxmd.com/read/29445431/outcome-recurrence-and-mortality-after-non-valvular-atrial-fibrillation-stroke-long-term-follow-up-study
#10
Antonio Arauz, Francisco Ruiz-Navarro, Miguel A Barboza, Angelica Ruiz, Jonathan Colin, Marisela Reyes, Humberto Silos, Carlos Cantu-Brito, Luis Murillo-Bonilla, Fernando Barinagarrementeria
Objective: Non-valvular atrial fibrillation (NVAF) is a major risk factor for ischemic stroke (IS) and a powerful predictor of mortality. This study investigates early and long-term outcome among patients with IS secondary to NVAF and identify the main factors associated with poor outcome, recurrence, and death. Methods: We analyzed the data from our consecutive NVAF acute IS database, over a period of 23 years. The endpoints were bad outcome (Modified Rankin Score ≥3), recurrence, and mortality at discharge, after 6 months, 12 months, and final follow-up...
December 2017: Journal of Vascular and Interventional Neurology
https://www.readbyqxmd.com/read/29439595/serum-uric-acid-levels-and-outcome-during-admission-in-acute-ischaemic-stroke-depending-on-renal-function
#11
José Carlos Arévalo-Lorido, Juana Carretero-Gómez, Nicolás Roberto Robles
BACKGROUND: The relationship between serum uric acid (SUA) levels and stroke is controversial. The discrepancies in the results could be due to the uneven setting of comorbidity. It is known that hyperuricaemia increases in parallel with the decline in renal function; however, there are few studies that adjust for renal disease. AIM: To investigate the relationship between SUA levels in the acute phase of ischaemic stroke according to the presence or absence of chronic kidney disease and clinical outcomes during admission...
February 13, 2018: International Journal of Neuroscience
https://www.readbyqxmd.com/read/29439126/mechanical-thrombectomy-of-acute-ischemic-stroke-with-a-new-intermediate-aspiration-catheter-preliminary-results
#12
Fabrizio Sallustio, Enrico Pampana, Alessandro Davoli, Stefano Merolla, Giacomo Koch, Fana Alemseged, Marta Panella, Vittoria Carla D'Agostino, Francesco Mori, Daniele Morosetti, Daniel Konda, Sebastiano Fabiano, Marina Diomedi, Roberto Gandini
BACKGROUND AND PURPOSE: To report clinical and procedural outcomes of acute ischemic stroke patients after endovascular treatment with the new thromboaspiration catheter AXS Catalyst 6. METHODS: Patients with anterior and posterior circulation stroke were selected. Successful reperfusion defined as a Thrombolysis in Cerebral Infarction (TICI) score ≥2 b and 3-month functional independence defined as a modified Rankin Scale (mRS) ≤2 were the main efficacy outcomes...
February 8, 2018: Journal of Neurointerventional Surgery
https://www.readbyqxmd.com/read/29434802/an-investigation-of-the-mechanism-of-dexmedetomidine-in-improving-postoperative-cognitive-dysfunction-from-the-perspectives-of-alleviating-neuronal-mitochondrial-membrane-oxidative-stress-and-electrophysiological-dysfunction
#13
Jie Chen, Na Shen, Xiaohui Duan, Yaning Guo
The aim of this study was to investigate the mechanism of dexmedetomidine in improving postoperative cognitive dysfunction from the perspectives of alleviating neuronal mitochondrial membrane oxidative stress and electrophysiological dysfunction. A total of 120 patients undergoing elective surgery under general anesthesia from June 2013 to May, 2016 were selected as the subjects of the study and randomly divided into the propofol + remifentanil and dexmedetomidine groups. The Rey Auditory Verbal Learning Test (AVLT) and Beck Depression Inventory (BDI) were performed at day 1 before operation and at day 1, 3, 5 and 15 after operation...
February 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29434800/protective-effects-of-scopolamine-and-penehyclidine-hydrochloride-on-acute-cerebral-ischemia-reperfusion-injury-after-cardiopulmonary-resuscitation-and-effects-on-cytokines
#14
Dengqin Wang, Qi Jiang, Xiuling Du
The objective of this study was to investigate the protective effects of scopolamine and penehyclidine hydrochloride on acute cerebral ischemia-reperfusion injury after cardiopulmonary resuscitation, and the effect on cytokine levels. Eighty patients with cardiac arrest admitted to our hospital from June 2011 to December 2015 were recruited and randomly divided into two groups (n=40 each). Following cardiopulmonary resuscitation, scopolamine was administered in the control group, whereas penehyclidine hydrochloride was administered in the observation group...
February 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29434154/the-clinical-features-of-ischemic-stroke-patients-for-whom-smoking-was-considered-the-sole-risk-factor-for-ischemic-stroke
#15
Takuya Fukuoka, Yoshihiko Nakazato, Hitoshi Kawasaki, Kei Ikeda, Tomotsugu Furuya, Akifumi Miyake, Takashi Mitsufuji, Yasuo Ito, Kazushi Takahashi, Nobuo Araki, Norio Tahahashi, Toshimasa Yamamoto
Objective The purpose of this study was to clarify the clinical features of ischemic patients for whom cigarette smoking was the sole risk factor for ischemic stroke. Methods Among the 1,329 patients (male, n=833; female, n=496) with acute ischemic stroke who were admitted to our hospital between April 2005 and September 2016, 346 (26%) were smokers (male, n=308 [36.9%]; female, 38 [7.6%]). In 42 (3.1%; male, n=41; female, n=1) cases, cigarette smoking was considered to be the sole risk factor for ischemic stroke...
February 9, 2018: Internal Medicine
https://www.readbyqxmd.com/read/29431878/characteristics-associated-with-outcome-in-first-ever-posterior-fossa-stroke-patients
#16
Kersten Villringer, Malgorzata Florczak-Rzepka, Ulrike Grittner, Peter Brunecker, Hans Tepe, Christian H Nolte, Jochen B Fiebach
BACKGROUND: Factors like infarct volume, infarct location and symptom severity can considerably influence long-term outcome in posterior fossa strokes. Therapy decision can sometimes be complicated by discrepancies between infarct volume and clinical severity. We aimed to evaluate imaging and clinical parameters possibly influencing long-term outcome in first-ever posterior fossa stroke patients. METHODS: Imaging was performed on a 3 T MRI scanner. Sixty-one out of 1795 patients from the observational 1000Plus and LOBI studies (clinicaltrials...
February 12, 2018: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
https://www.readbyqxmd.com/read/29429905/health-related-quality-of-life-in-patients-with-poststroke-epilepsy
#17
Yaroslav Winter, Naeimeh Daneshkhah, Nikolaus Galland, Isabel Kotulla, Anna Krüger, Sergiu Groppa
BACKGROUND: Lesional epilepsy is an important long-term sequela of stroke. Data on health-related quality of life (HrQoL) in patients with poststroke epilepsy are limited. We investigated HrQoL in patients with epilepsy after ischemic stroke and identified independent HrQoL-determinants. METHODS AND PATIENTS: All patients with acute ischemic stroke, who were permanent residents in the district Marburg-Biedenkopf (Hessia, Germany, reference population 240,000 inhabitants) were recruited within 12months in the population-based Marburg Stroke Register (MARSTREG)...
February 8, 2018: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/29428328/mean-platelet-volume-is-associated-with-early-neurological-deterioration-in-patients-with-branch-atheromatous-disease-involvement-of-platelet-activation
#18
Satoru Oji, Dembo Tomohisa, Wataru Hara, Takashi Tajima, Masato Suzuki, Akane Saito, Norihito Yoshida, Kyoichi Nomura
BACKGROUND: The most attentive clinical problem in patients with branch atheromatous disease (BAD) is early neurological deterioration (END). Although the platelet activation (PA) is involved in pathogenesis, the relationship between PA and END has remained unclear. We investigated clinical data including mean platelet volume (MPV, fL) as a marker for PA to identify clinically useful biomarkers for END. METHODS: A total of 64 patients with BAD were investigated retrospectively, and divided into 2 groups based on whether neurologic symptoms deteriorated or not: BAD with and without END (END and non-END)...
February 7, 2018: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
https://www.readbyqxmd.com/read/29427575/rhythm-perception-and-production-abilities-and-their-relationship-to-gait-after-stroke
#19
Kara K Patterson, Jennifer S Wong, Svetlana Knorr, Jessica A Grahn
OBJECTIVES: To assess rhythm abilities, describe their relationship to clinical presentation, and to determine if rhythm production independently contributes to temporal gait asymmetry post-stroke. DESIGN: Cross-sectional. SETTING: Large urban rehabilitation hospital and university. PARTICIPANTS: Individuals with subacute and chronic stroke (n=39) and data for healthy adults extracted from a pre-existing database (n=21)...
February 7, 2018: Archives of Physical Medicine and Rehabilitation
https://www.readbyqxmd.com/read/29416573/do-all-acute-stroke-patients-receiving-tpa-require-icu-admission
#20
Farid Sadaka, Amar Jadhav, Jacklyn O'Brien, Steven Trottier
Background: Limited resources warrant investigating models for predicting which stroke tissue-type plasminogen activator (tPA) patients benefit from admission to neurologic intensive care unit (neuroICU). Methods: This model classifies patients who on day 1 of their ICU admission are predicted to receive one or more of 30 subsequent active life supporting treatments. Two groups of patients were compared: low risk monitor (LRM) (patients who did not receive active treatment (AT) on the first day and whose risk of ever receiving active treatment was ≤ 10%) and AT (patients who received at least one treatment on any day of their ICU admission)...
March 2018: Journal of Clinical Medicine Research
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